Subscribe: pubmed: Hallman M[Author]
http://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=0po2vkO2n4NHnM_rEGpLR83Fk3zyUL5xFFA5NnIgXUz
Preview: pubmed: Hallman M[Author]

pubmed: Hallman M[Author]



NCBI: db=pubmed; Term=Hallman M[Author]



 



Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants.
Related Articles

Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants.

Acta Paediatr. 2017 Nov 04;:

Authors: Juujärvi S, Saarela T, Hallman M, Aikio O

Abstract
AIM: Symptomatic patent ductus arteriosus may lead to serious complications in extremely preterm and extremely low birth weight infants and is often resistant to medication. We evaluated early intravenous paracetamol for pain prevention during respiratory therapy, in an attempt to understand the ductal treatment of such infants.
METHODS: Our cohort were 295 extremely preterm or extremely low birth weight infants, born at less than 28 weeks or 1,000g, respectively, who were treated in the neonatal intensive care unit of Oulu University Hospital from 2002-2015, before and after intravenous paracetamol was introduced in June 2009. Ductal closure dates, paracetamol medication details, morbidities and mortality data were evaluated.
RESULTS: Intravenous paracetamol was given to 128 infants, starting at a median of 4.4 hours age (range 0-169 hours), with a mean total dosage of 212 mg/kg (range 7.5 - 1175 mg/kg). We also included 167 controls who were mainly treated before we used intravenous paracetamol. Ibuprofen (p<0.001) and ligation (p = 0.002) were lower in the paracetamol group than controls. No adverse effects were detected. Paracetamol was not associated with other morbidities.
CONCLUSION: We found that early use of intravenous paracetamol decreased the incidence of ductal therapies in extremely premature or extremely low birth weight infants. This article is protected by copyright. All rights reserved.

PMID: 29105147 [PubMed - as supplied by publisher]