Subscribe: pubmed: keski-oja j
http://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=0WPi1Of3Vv13c4HUn_YTrz7X6_8yqyOGGJIeGT1E99_
Preview: pubmed: keski-oja j

pubmed: keski-oja j



NCBI: db=pubmed; Term=keski-oja j



 



Netrin-1: A regulator of cancer cell motility?
(image) Related Articles

Netrin-1: A regulator of cancer cell motility?

Eur J Cell Biol. 2016 Nov;95(11):513-520

Authors: Ylivinkka I, Keski-Oja J, Hyytiäinen M

Abstract
Netrins form a family of secreted and membrane-associated proteins, netrin-1 being the prototype and most investigated member of the family. The major physiological functions of netrin-1 lie in the regulation of axonal development as well as morphogenesis of different branched organs, by promoting the polarity of migratory/invasive front of the cell. On the other hand, netrin-1 acts as a factor preventing cell apoptosis. These events are mediated via a range of different receptors, including UNC5 and DCC-families. Cancer cells often employ developmental pathways to gain survival and motility advantage. Within recent years, there has been increasing number of observations of upregulation of netrin-1 expression in different forms of cancer, and the increased expression of netrin-1 has been linked to its functions as a survival and invasion promoting factor. We review here recent advances in the netrin-1 related developmental processes that may be of special interest in tumor biology, in addition to the known functions of netrin-1 in tumor biology with special focus on cancer cell migration.

PMID: 27793362 [PubMed - indexed for MEDLINE]