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Preview: Brightsurf Science News :: Inherited Cancer News

Inherited Cancer Current Events and Inherited Cancer News from Brightsurf



Inherited Cancer Current Events and Inherited Cancer News Events, Discoveries and Articles from Brightsurf



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Hidden costs of skin cancer caused by workplace sun exposure revealed

Thu, 26 Apr 18 00:12:20 -0700

Skin cancer cases attributable to work-related sun exposure could be costing millions of dollars, and must be better addressed by policymakers.



Obesity inhibits key cancer defense mechanism

Thu, 26 Apr 18 00:16:10 -0700

Obesity could enhance cancer development while aspirin might prevent it -- a new insight into potential targets for cancer prevention.



A biochemical process in plants is imitated to curb the reproduction of colon cancer tumor cells

Thu, 26 Apr 18 00:00:50 -0700

University of Cordoba research team has developed a tool to erase molecular tags that silence genes involved in tumor growth.



New metric defines areas of highest prostate cancer burden

Thu, 26 Apr 18 00:02:20 -0700

To improve the impact of outreach efforts, researchers develop a better way to identify areas with high risk patients.



Metastatic cancer gorges on fructose in the liver

Thu, 26 Apr 18 00:06:50 -0700

Biomedical engineers at Duke University have demonstrated that metastatic cancer cells can reprogram their metabolism to thrive in new organs. Cells originating from colorectal cancer change their dietary habits to capitalize on the high levels of fructose often found in the liver. The finding offers both general and specific insights into new ways of fighting metastatic cancer.



RNA editing study shows potential for more effective precision cancer treatment

Thu, 26 Apr 18 00:08:00 -0700

If there is one thing all cancers have in common, it is they have nothing in common. A multi-center study led by The University of Texas MD Anderson Cancer Center has shed light on why proteins, the seedlings that serve as the incubator for many cancers, can vary from cancer to cancer and even patient to patient, a discovery that adds to a growing base of knowledge important for developing more effective precision therapies.



Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy

Thu, 26 Apr 18 00:11:10 -0700

Data from 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers, show new genetic alterations, and 'high mutation burden' that is an FDA-approved marker for treatment with immunotherapy.



BU: Obese patients underrepresented in cancer clinical trials

Wed, 25 Apr 18 00:00:20 -0700

A new review by Boston University School of Public Health researchers found that less than one-fifth of participants in cancer-related clinical trials are obese.



In Huntington's disease, heart problems reflect broader effects of abnormal protein

Tue, 24 Apr 18 00:15:10 -0700

Researchers investigating a key signaling protein in Huntington's disease describe deleterious effects on heart function, going beyond the disease's devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease.



Patients in major prostate cancer study older, sicker than average patient population

Tue, 24 Apr 18 00:00:40 -0700

Researchers at Henry Ford Hospital compared the patient population of a major US prostate cancer study with patients found in three US cancer databases, ultimately finding the patients of the study to be inconsistent with the average prostate cancer patient. The researchers found the patients of the Prostate Cancer Intervention versus Observation Trial (PIVOT) to be between three and eight times more likely to die than real-world patients.



What can a tasty milkshake teach us about the genetics of heart disease?

Tue, 24 Apr 18 00:01:30 -0700

Analysis of high-resolution genomic data in a large study population reveals novel low-frequency polymorphisms that drive response to dietary lipids and medication.



Research shows possible new target for immunotherapy for solid tumors

Tue, 24 Apr 18 00:02:50 -0700

Research from the University of Cincinnati (UC) reveals a potential new target to help T cells (white blood cells) infiltrate certain solid tumors.



'Incompatible' donor stem cells cure adult sickle cell patients

Tue, 24 Apr 18 00:05:50 -0700

Doctors at the University of Illinois Hospital have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be incompatible, thanks to a new transplant treatment protocol.



People with false-positive cancer screening results may be more likely to receive future screening

Mon, 23 Apr 18 00:01:30 -0700

An analysis of electronic medical records indicates that patients who previously had a false-positive breast or prostate cancer screening test are more likely to obtain future recommended cancer screenings.



Odd one out: Protein goes against the family to prevent cancer donate

Mon, 23 Apr 18 00:03:40 -0700

Melbourne researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers. The research team showed switching off a gene called NF-κB1 caused spontaneous development of stomach cancers, driven by chronic inflammation. The study also revealed that immunotherapy may prove to be a significant tool for treating stomach cancers that are driven by runaway inflammation, warranting further investigation.



The role of 'extra' DNA in cancer evolution and therapy resistance

Mon, 23 Apr 18 00:15:40 -0700

Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. In a recent paper in Nature Genetics, the team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA.



Vitamin A derivative selectively kills liver cancer stem cells

Mon, 23 Apr 18 00:00:10 -0700

Acyclic retinoid, an artificial compound derived from vitamin A, has been found to prevent the recurrence of hepatocellular carcinoma (HCC), the most common form of liver cancer. Now, in research published in Proceedings of the National Academy of Sciences, scientists have discovered that the compound targets one class of cancer stem cells, preventing them from giving rise to new tumors.



UNC scientists create better laboratory tools to study cancer's spread

Mon, 23 Apr 18 00:02:20 -0700

In the journal Nature Biomedical Engineering, UNC Lineberger Comprehensive Cancer Center's Andrew Wang, MD, and colleagues report they have developed tissue-engineered models for cancer metastases that reflect the microenvironment around tumors that promotes their growth.



Six in 7 women at high risk of breast cancer shun tamoxifen as a preventative measure

Mon, 23 Apr 18 00:03:20 -0700

Six in seven women with a family history of breast cancer opt out of taking tamoxifen as a preventative measure, according to a study funded by Cancer Research UK and published in Breast Cancer Research and Treatment today.



Correcting tiny differences in patient's position for radiotherapy could increase survival chances

Sat, 21 Apr 18 00:14:00 -0700

Very small differences in the way a patient lies during radiotherapy treatment for lung or esophageal cancer can have an impact on how likely they are to survive, according to research presented at the ESTRO 37 conference.



Skin cancers linked with reduced risk of Alzheimer's disease

Thu, 19 Apr 18 00:02:50 -0700

Previous studies have demonstrated a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including non-melanoma skin cancers (including squamous cell cancers and basal cell cancers).



Researchers use CRISPR to edit DNA outside of the cell for the first time

Thu, 19 Apr 18 00:06:40 -0700

Scientists at Christiana Care Health System's Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.



Study examines sperm production in men with testicular cancer

Thu, 19 Apr 18 00:05:20 -0700

In a study of men with testicular cancer, increasing tumor size relative to testis size was linked with a reduced ability to produce sperm.



Bedside art therapy decreases pain and anxiety in patients with cancer

Thu, 19 Apr 18 00:05:10 -0700

A brief bedside visual art intervention (BVAI) facilitated by art educators improved mood and reduced pain and anxiety in a study of inpatients with hematological cancers.



GLUT5 fluorescent probe fingerprints cancer cells

Thu, 19 Apr 18 00:10:00 -0700

Getting the results of a cancer biopsy can take up to two weeks. What if it could happen in 10 minutes? In two new papers, a team of chemists and engineers from Michigan Technological University lay the groundwork for cancer detection and diagnostics based on a fluorescent GLUT5 probe. Documented in the new research, a cancer's type and malignancy changes the GLUT5 activity in a cell, creating a detectable 'fingerprint' of cancer.



Discovery adds to evidence that some children are predisposed to develop leukemia

Thu, 19 Apr 18 00:13:50 -0700

St. Jude Children's Research Hospital scientists have discovered a fourth gene that can predispose carriers to the most common childhood cancer, expanding the list of genes to include in cancer screening.



Landmark study links tumor evolution to prostate cancer severity

Thu, 19 Apr 18 00:12:40 -0700

Findings from Canadian Prostate Cancer Genome Network (CPC-GENE) researchers and their collaborators, published today in Cell, show that the aggressiveness of an individual prostate cancer can be accurately assessed by looking at how that tumor has evolved. This information can be used to determine what type and how much treatment should be given to each patient, or if any is needed at all.



Defect in debilitating neurodegenerative disease reversed in mouse nerves

Thu, 19 Apr 18 00:00:50 -0700

Scientists have developed a new drug compound that shows promise as a future treatment for Charcot-Marie-Tooth disease, an inherited, often painful neurodegenerative condition that affects nerves in the hands, arms, feet and legs. The researchers used the compound to treat the nerves of mice harboring the genetic defects that cause the disease.



Variants in non-coding DNA contribute to inherited autism risk

Thu, 19 Apr 18 00:02:00 -0700

In recent years, researchers have firmly established that gene mutations appearing for the first time, called de novo mutations, contribute to approximately one-third of cases of autism spectrum disorder. In a new study, a team led by scientists at University of California San Diego School of Medicine have identified a culprit that may explain some of the remaining risk: rare inherited variants in regions of non-coding DNA. The findings are published April 20 in Science.



Improved method of delivering anti-cancer drugs

Wed, 18 Apr 18 00:16:20 -0700

A new non-toxic method for delivering anti-cancer drugs to specific parts of the human body could mean the end of the severe and nasty side effects associated with many cancer therapies, according to researchers at Cardiff University's School of Pharmacy and Pharmaceutical Sciences.



Iron Age breeding practices likely influenced lack of stallion lineages in modern horses

Wed, 18 Apr 18 00:11:10 -0700

Selective breeding just before and during the Iron Age nearly 3,000 years ago is likely the reason for the lack of variability in modern domestic horses' paternally inherited DNA, a trait unique among livestock animals.



Researchers identified a protein associated with breast cancer

Wed, 18 Apr 18 00:12:20 -0700

Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.



Diagnosing, treating neuropathy symptoms in cancer patients not exact science

Tue, 17 Apr 18 00:07:10 -0700

Most of the roughly 15.5 million cancer survivors in the US receive chemotherapy, and roughly 65 percent develop some degree of the chemotherapy-induced nerve damage known as peripheral neuropathy.



Scientists find some human cancers to be 'evolutionary accidents'

Tue, 17 Apr 18 00:11:40 -0700

New research, published in Biological Reviews and conducted by researchers from the University of Liverpool and Escola Superior de Ciências da Saúde (Brasília, Brazil) has found some type of cancers unique to humans may be a result of evolutionary accidents.



A new, streamlined approach to diagnosing and treating bowel cancer

Tue, 17 Apr 18 00:13:50 -0700

Researchers at the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide have discovered a faster, more cost-effective way to determine which DNA mutations cause human bowel cancer.



Study reports possible novel method for stopping untreatable pediatric brain cancers

Tue, 17 Apr 18 00:12:40 -0700

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists report in the journal Molecular Cancer Therapeutics testing the small molecule 6-thio-2'deoxyguanosine (6-thio-dG) in brain cancer stem cells derived from tumor cells donated by patients. Researchers also tested the treatment in humanized mouse models of pediatric brain cancer.



FDA approves new standard of care for kidney cancer

Tue, 17 Apr 18 00:01:40 -0700

The US Food and Drug Administration granted approval to the combination of two immunotherapy drugs, ipilimumab and nivolumab, for the treatment of metastatic kidney cancer.



Global ROS1 initiative: A patient-researcher collaboration targeting ROS1 cancer

Tue, 17 Apr 18 00:04:20 -0700

CU presentation at AACR2018 describes the first research-focused group of patients organized around the genetic mutation that creates their cancer, namely changes to the gene ROS1.



For aggressive breast cancer in the brain, researchers clarify immune response

Tue, 17 Apr 18 00:04:50 -0700

In a preliminary study presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers from the UNC Lineberger Comprehensive Cancer Center revealed findings for what kind of immune response the body is staging against triple negative breast cancer that has spread to the brain. They hope they can use these findings to improve patient responses to drugs that work by unleashing the immune system against cancer.



OncoDNA announces publication of peer-reviewed study in Oncotarget assessing the utility of its uniq

Tue, 17 Apr 18 00:06:30 -0700

OncoDNA treatment recommendation followed in 60% of cases. 93% of treatment decisions were made based on a holistic approach combining next generation sequencing (NGS) and multiple biomarker analysis provided by OncoDNA. 27% of late-stage patients treated with OncoDNA-recommended therapies had overall survival >12 months, compared to a typical average of no more than six months.



Precancerous colon polyps in patients with Lynch syndrome exhibit immune activation

Mon, 16 Apr 18 00:03:40 -0700

Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center. The preclinical research challenges traditional models of cancer immune activation and suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups.



When prostate cancer reaches bone, bone cells may drive overall growth of the disease

Mon, 16 Apr 18 00:14:50 -0700

When prostate cancer metastasizes to bone, it can become especially dangerous. A CU study at AACR18 hints at why: cells involved in these bone metastases may release signals that drive the progression of the disease.



Study examines accuracy of test for lymph node metastases in women with breast cancer

Mon, 16 Apr 18 00:15:30 -0700

A new BJS (British Journal of Surgery) study indicates that axillary ultrasound imaging is inferior for detecting axillary node metastasis in patients with breast cancer.



Three-fold higher risk of cancer after acute thrombosis in the leg

Mon, 16 Apr 18 00:16:20 -0700

The risk of developing cancer is more than three times higher during the first six months following blood clot in the leg, compared with the background population. This is shown by a register-based study that medical doctor and Ph.D. Jens Sundbøll has recently published in the journal Circulation. Jens Sundbøll is employed at the Department of Clinical Epidemiology, which is part of the Department of Clinical Medicine at Aarhus University and Aarhus University Hospital.



Is whole-brain radiation still best for brain metastases from small-cell lung cancer?

Mon, 16 Apr 18 00:02:40 -0700

University of Colorado Cancer Center study compares outcomes of 5,752 small-cell lung cancer patients who received whole-brain radiation therapy (WBRT) with those of 200 patients who received stereotactic radiosurgery (SRS), finding that the median overall survival was actually longer with SRS (10.8 months with SRS versus 7.1 months with WBRT).



Man-made antibodies show promise in attacking cancer cells in animal models

Mon, 16 Apr 18 00:04:30 -0700

Using chemotherapy along with aptamers -- lab-made molecules that function like antibodies -- Duke Health researchers showed that they can zero in on and kill prostate cancer tumors in mice while leaving healthy tissue unscathed.



First-in-human clinical trial of new targeted therapy drug reports promising responses for multiple

Sun, 15 Apr 18 00:16:20 -0700

A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known as RET. The drug appears to be promising as a potential therapy for RET-driven cancers, such as medullary and papillary thyroid, non-small cell lung, colorectal and bile duct cancers, which have been historically difficult to treat.



A novel precision cancer model opens doors to personalized cancer treatment

Fri, 13 Apr 18 00:05:50 -0700

Researchers from the Seve Ballesteros Foundation-CNIO Brain Tumour Group at the Spanish National Cancer Research Centre (CNIO) have developed an extremely powerful and versatile mouse model that will improve cancer research and accelerate preclinical testing of novel targeted therapies. Their work appears in Nature Communications.



To starve pancreatic tumors, researchers seek to block 'self-eating,' other fuel sources

Fri, 13 Apr 18 00:15:00 -0700

UNC Lineberger Comprehensive Cancer Center researchers and their collaborators are reporting preclinical findings for a potential two-treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual Meeting in Chicago. The findings will be presented from 8 a.m. to noon on Wednesday.



Nutrition, physical activity guidelines and survival after colon cancer diagnosis

Thu, 12 Apr 18 00:10:30 -0700

A lifestyle consistent with the American Cancer Society (ACS) guidelines to maintain a healthy weight, engage in regular physical activity, and eat a diet rich in nutritious foods was associated with a lower risk of death in patients with colon cancer.