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Preview: Comments on Whole Health Source: The Diet-Heart Hypothesis: Oxidized LDL, Part I

Comments on Whole Health Source: The Diet-Heart Hypothesis: Oxidized LDL, Part I





Updated: 2018-04-25T03:20:05.467-07:00

 



@Unknown: "Based on our analysis, we were su...

2015-05-11T11:58:04.470-07:00

@Unknown:

"Based on our analysis, we were surprised to find that, instead of increasing the amount of cholesterol uptake and accumulation in the macrophage foam cells, mildly oxidized LDL almost completely prevents increases in cholesterol," van der Westhuyzen said.

prevents increase in cholesterol?


Is that a concern and how?



How do you target Ox-LDL without affecting LDL? D...

2015-05-11T08:35:22.576-07:00

How do you target Ox-LDL without affecting LDL?

Does the particle size theory still hold true?



Did you see this article about some recent researc...

2014-10-27T09:47:37.350-07:00

Did you see this article about some recent research? Maybe a little oxidation is good!

http://www.sciencedaily.com/releases/2014/09/140904121247.htm



Five years after the beginning of this blog, now r...

2014-09-19T08:43:47.274-07:00

Five years after the beginning of this blog, now research is pointing toward the importance of LDL as a carrier of cholesterol and fat to the brain for neurological health and how oxidized LDL has a diminished capacity to do this and is probably causative for CAD. Few cardiologists however are distinguishing between oxidized and non-oxidized LDL in their patients and continue to prescribe medications that greatly reduce ALL LDLs--protecting the heart but destroying the brain. Thoughts?



This post is called "The Diet-Heart Hypothesi...

2013-10-11T14:32:53.213-07:00

This post is called "The Diet-Heart Hypothesis: Oxidized LDL, Part I". I can't find a Part II, does it exist?



Dear Stephan, Thank you for your very informative ...

2013-08-06T01:20:25.639-07:00

Dear Stephan,
Thank you for your very informative blog. I myself suffer from atherosclerosis and I am looking for new information that will allow me to decrease or even stop taking statins with all the side effects. I will look forward to your next post on diet and other ways to help.



Hey everyone, great discussion here, hopefully peo...

2012-04-26T04:26:56.585-07:00

Hey everyone, great discussion here, hopefully people are still viewing this post and commenting!

Can someone explain how and why Macrophages ingest oxidised LDL?

Many thanks,

Alex,



At present no one knows what is Ox-LDL. Take my wo...

2011-03-15T22:04:43.948-07:00

At present no one knows what is Ox-LDL. Take my word-I was one of the co-discoverers of Ox-LDL. Before we could understand it better, tocopherol advocates did several shot gun approach studies and shot down the hypothesis prematurely. Now vitamin E advocates are distancing themselves from tocopherols!
Measurement of "ox-LDL" is real and could be an important predictor-but we have a long way to go. Research isn dwindling on the topic.



Have you found anyway to get one's blood teste...

2009-11-11T12:32:53.707-08:00

Have you found anyway to get one's blood tested for OXY-LDL?




See http://wiki.xtronics.com/index.php/Tests_for_Preventative_Heart_Health#Oxidized_LDL_assay



I an not a chemist or have any scientific backgrou...

2009-11-10T15:20:17.190-08:00

I an not a chemist or have any scientific background so please excuse my laymans understanding.

However I have a grave concern as my daughter is considering undergoing treatment for fat reduction using Radio Frequency and Ultra Sound treatment which both rely on heat.
It is my understanding that the heat will oxidise both the fat and cholesterol and lead to blocking of the arteries. The amount of fat lost in each session by this liquifying process also gives me concern that the liver will not be able to process this effectively in bulk and it will migrate to other organs.



Have you found anyway to get one's blood teste...

2009-10-16T10:17:23.647-07:00

Have you found anyway to get one's blood tested for OXY-LDL?

My hunch is we should be looking at LDL-P and oxy-LDL



I found this interesting reading today. First a la...

2009-10-13T11:43:27.028-07:00

I found this interesting reading today. First a laymans guide to the paper from Spacedoc's website
Infections and Vulnerable Plaques
and you'll find the full text of Ravnskov U, McCully KS. paper here on the nutrition and metabolism society website.
Vulnerable Plaque Formation from Obstruction of Vasa Vasorum by Homocysteinylated and Oxidized Lipoprotein Aggregates Complexed with Microbial Remnants and LDL Autoantibodies



Totally missing from this is dietary sources of ox...

2009-09-08T12:24:24.966-07:00

Totally missing from this is dietary sources of oxy-chol which we know is a cause of CAD.

Only in the west, where heart disease is increasing, do we eat food that has been stored for so long. We know that powered milk, powdered eggs are a source of dietary oxy-chol. We also know that refrigerated meats have more an more oxy-chol as time passes. We also know that fast cooking methods limit the amount of oxy-chol in our food.

Dietary cholesterol is not the devil - it is dietary oxy-chol that needs looking at. The few studies of food content are from Australia. Many questions about food storage and preparation in association with oxy-chol are not answered.

It is not clear what the relative risk of dietary-oxy-chol vs oxy-chol that forms in our body are.



Mamatha, I appreciate your support. Dan, I don&...

2009-08-09T20:49:37.453-07:00

Mamatha,

I appreciate your support.

Dan,

I don't really know about the effects of oxidized cholesterol in food at this point.



Is oxidized cholesterol in food also a concern? ...

2009-08-08T10:30:12.322-07:00

Is oxidized cholesterol in food also a concern? I remember reading that it was present in powdered skim milk. It seemed strange to me that milk without fat could have any sort of cholesterol in it.



Stephan, I've been following your blog for the...

2009-08-07T14:59:29.649-07:00

Stephan,
I've been following your blog for the last couple of weeks. I decided to delurk today and express my gratitude for all the great work you are doing.

Best wishes,
Mamatha



@Lynn M. Heart and brain are all part of the same...

2009-08-07T09:14:22.702-07:00

@Lynn M.

Heart and brain are all part of the same system, with lots of shared feedback and control mechanisms, common supply of oxygen, nutrients, etc. That anyone (particularly scientists, who ought to know better) would think of them as being completely separable reflects a lack of much thinking at all.

Second point is that it is implied that the common cause of heart disease and Alzheimer's is high cholesterol, as opposed to that being a symptom of a systemic disorder affecting both the blood and brain, such as hyperglycemia or hyperinsulinemia. Associative evidence carries little weight toward causality, unless you at least have a hypothetical mechanism by which excess serum cholesterol leads to Alzheimer's.



Dave, These were the quotes I saw attributed to D...

2009-08-06T20:48:35.202-07:00

Dave,

These were the quotes I saw attributed to Dr. Whitmer in the WebMD article:
"People tend to think of the brain and the heart as totally separate, but they are not," study co-author Rachel A. Whitmer, PhD of Kaiser Permanente Division of Research in Oakland, Calif., tells WebMD. "We are learning that what is good for the heart is also good for the brain -- and that midlife is not too soon to be thinking about risk factors for dementia."

"But it is safe to assume that most people whose total cholesterol was high had high levels of bad cholesterol because about two-thirds of total cholesterol reflects LDL, Whitmer says."

I guess my critical thinking is on the blink, because I don't see what is fantastically stupid about those comments. I'm not saying I agree with the conclusions of the study,and I do understand that correlation is not causation. I thought I had seen the idea that what is good for the heart is good for the brain substantiated elsewhere. Is that idea wrong or unproven?

The second comment I see as either true or false, not stupid or smart. Is that statement wrong?



"High Cholesterol Linked to Alzheimer's&q...

2009-08-06T07:48:06.474-07:00

"High Cholesterol Linked to Alzheimer's"

Correlation is not causation.

I love the fantastically stupid comment by Rachel Whitmer in the WebMD article. Great example of the lack of critical thinking amongst health-care professionals.



In the discussion they point to Lowering of body ...

2009-08-06T04:21:11.752-07:00

In the discussion they point to
Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteinsThese observations indicate that the reduction of body iron stores by venesection can increase the oxidation resistance of serum VLDL/LDL in regularly smoking men.






Heres the paper - I forgot to give the details. Am...

2009-08-06T03:53:22.768-07:00

Heres the paper - I forgot to give the details.
American Journal of Epidemiology Vol. 148, No. 5: 445-451

Donation of Blood Is Associated with Reduced Risk of Myocardial Infarction
The Kuopio Ischaemic Heart Disease Risk Factor Study



The Kuopio Ischaemic Heart Disease Risk Factor Stu...

2009-08-06T03:51:50.811-07:00

The Kuopio Ischaemic Heart Disease Risk Factor Study

"In a Cox proportional hazards model adjusting for age, examination years and all other predictive coronary disease risk factors, blood donors (middle-aged males had a 88% reduced risk (relative hazard = 0.12, 95% confidence interval 0.02–0.86, p = 0.035) of acute myocardial infarction, compared with non-blood donors. "

88% less risk of an infarct by donating blood!






Maybe it's been discussed already but how woul...

2009-08-06T02:30:42.043-07:00

Maybe it's been discussed already but how would you ask for an oxidized LDL test? What's it called since it's not included in the lipid panel.