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Preview: Brightsurf Science News :: Breast Cancer News

Breast Cancer Current Events and Breast Cancer News from Brightsurf



Breast Cancer Current Events and Breast Cancer News Events, Discoveries and Articles from Brightsurf



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A non-coding RNA lasso catches proteins in breast cancer cells

Tue, 24 Apr 18 00:07:40 -0700

A Danish-German research team has shown that not only the where and when of long non-coding RNA expression is important for their function but also the how. The results can have a big impact on our understanding of dynamic regulation of gene expression in biological processes.



Changes in breast tissue increase cancer risk for older women

Tue, 24 Apr 18 00:15:50 -0700

Researchers in Norway, Switzerland, and the United States have identified age-related differences in breast tissue that contribute to older women's increased risk of developing breast cancer. The findings, published April 24 in the journal Cell Reports, may help scientists better understand how breast cells change during the aging process, enabling doctors to catch the signs of cancer earlier.



Patients in major prostate cancer study older, sicker than average patient population

Tue, 24 Apr 18 00:00:40 -0700

Researchers at Henry Ford Hospital compared the patient population of a major US prostate cancer study with patients found in three US cancer databases, ultimately finding the patients of the study to be inconsistent with the average prostate cancer patient. The researchers found the patients of the Prostate Cancer Intervention versus Observation Trial (PIVOT) to be between three and eight times more likely to die than real-world patients.



Research shows possible new target for immunotherapy for solid tumors

Tue, 24 Apr 18 00:02:50 -0700

Research from the University of Cincinnati (UC) reveals a potential new target to help T cells (white blood cells) infiltrate certain solid tumors.



People with false-positive cancer screening results may be more likely to receive future screening

Mon, 23 Apr 18 00:01:30 -0700

An analysis of electronic medical records indicates that patients who previously had a false-positive breast or prostate cancer screening test are more likely to obtain future recommended cancer screenings.



Odd one out: Protein goes against the family to prevent cancer donate

Mon, 23 Apr 18 00:03:40 -0700

Melbourne researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers. The research team showed switching off a gene called NF-κB1 caused spontaneous development of stomach cancers, driven by chronic inflammation. The study also revealed that immunotherapy may prove to be a significant tool for treating stomach cancers that are driven by runaway inflammation, warranting further investigation.



How to hijack degrading complexes to put cancer cells asleep

Mon, 23 Apr 18 00:06:50 -0700

Palbociclib is a drug used for the treatment of advanced estrogen-receptor-positive breast cancer. Researchers at the Universities of Dundee and Newcastle and their colleagues investigated the drug's mode of action in more detail and uncovered the proteasome, a cellular degradation machinery vital for the control of cell proliferation, as its yet unknown target. Their discovery could potentially help expand palbociclib-based breast cancer treatments and identify patients that would profit most from this medication.



Did last ice age affect breastfeeding in Native Americans?

Mon, 23 Apr 18 00:00:20 -0700

Biologists have been puzzled by the evolutionary adaptation behind a common tooth trait of northern Asians and Native Americans: shovel-shaped incisors. A UC Berkeley analysis of archeological specimens shows that nearly 100 percent of early Native Americans had shoveled incisors, and genetic evidence pinpoints the selection to the Beringian standstill 20,000 years ago. Leslea Hlusko proposes that a trait linked to shoveling, mammary duct growth, was selected to provide vitamin D and fat to infants.



Vitamin A derivative selectively kills liver cancer stem cells

Mon, 23 Apr 18 00:00:10 -0700

Acyclic retinoid, an artificial compound derived from vitamin A, has been found to prevent the recurrence of hepatocellular carcinoma (HCC), the most common form of liver cancer. Now, in research published in Proceedings of the National Academy of Sciences, scientists have discovered that the compound targets one class of cancer stem cells, preventing them from giving rise to new tumors.



UNC scientists create better laboratory tools to study cancer's spread

Mon, 23 Apr 18 00:02:20 -0700

In the journal Nature Biomedical Engineering, UNC Lineberger Comprehensive Cancer Center's Andrew Wang, MD, and colleagues report they have developed tissue-engineered models for cancer metastases that reflect the microenvironment around tumors that promotes their growth.



Six in 7 women at high risk of breast cancer shun tamoxifen as a preventative measure

Mon, 23 Apr 18 00:03:20 -0700

Six in seven women with a family history of breast cancer opt out of taking tamoxifen as a preventative measure, according to a study funded by Cancer Research UK and published in Breast Cancer Research and Treatment today.



Targeted radiotherapy for breast cancer offers good quality of life and fewer side effects

Sun, 22 Apr 18 00:14:30 -0700

Quality of life for women treated with a more targeted radiotherapy treatment -- called accelerated partial breast irradiation -- is at least as good as quality of life for women treated with standard radiotherapy, according to research presented at the ESTRO 37 conference and published simultaneously in The Lancet Oncology.



Researchers report four new insights into diet and health

Sun, 22 Apr 18 00:15:00 -0700

What we eat plays a significant role in our health. The Experimental Biology 2018 meeting (EB 2018) will showcase new research into how diet could be used to fight cancer and how specific eating patterns can encourage weight loss.



Correcting tiny differences in patient's position for radiotherapy could increase survival chances

Sat, 21 Apr 18 00:14:00 -0700

Very small differences in the way a patient lies during radiotherapy treatment for lung or esophageal cancer can have an impact on how likely they are to survive, according to research presented at the ESTRO 37 conference.



New advances in the fight against cancer

Sat, 21 Apr 18 00:14:20 -0700

Research into cancer can provide new insight into how this disease works and how it can be stopped. The Experimental Biology 2018 meeting (EB 2018) will showcase innovative research that could lead to new ways to treat and prevent cancer.



New microscope reveals biological life as you've never seen it before

Fri, 20 Apr 18 00:09:00 -0700

Astronomers developed a 'guide star' adaptive optics technique to obtain the most crystal-clear and precise telescopic images of distant galaxies, stars and planets. Now a team of scientists are borrowing the very same trick. They've combined it with lattice light-sheet to create a new microscope to capture unprecedented images of biology. The work -- a collaboration between researchers at Howard Hughes Medical Institute, Boston Children's Hospital and Harvard Medical School -- is detailed in a new paper in Science.



Cancer: Tumor transition states

Thu, 19 Apr 18 00:02:00 -0700

Researchers at the Université libre de Bruxelles define for the first time the tumor transition states occurring during cancer progression and identify the tumor cell populations responsible for metastasis.



Skin cancers linked with reduced risk of Alzheimer's disease

Thu, 19 Apr 18 00:02:50 -0700

Previous studies have demonstrated a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including non-melanoma skin cancers (including squamous cell cancers and basal cell cancers).



Study examines sperm production in men with testicular cancer

Thu, 19 Apr 18 00:05:20 -0700

In a study of men with testicular cancer, increasing tumor size relative to testis size was linked with a reduced ability to produce sperm.



Bedside art therapy decreases pain and anxiety in patients with cancer

Thu, 19 Apr 18 00:05:10 -0700

A brief bedside visual art intervention (BVAI) facilitated by art educators improved mood and reduced pain and anxiety in a study of inpatients with hematological cancers.



GLUT5 fluorescent probe fingerprints cancer cells

Thu, 19 Apr 18 00:10:00 -0700

Getting the results of a cancer biopsy can take up to two weeks. What if it could happen in 10 minutes? In two new papers, a team of chemists and engineers from Michigan Technological University lay the groundwork for cancer detection and diagnostics based on a fluorescent GLUT5 probe. Documented in the new research, a cancer's type and malignancy changes the GLUT5 activity in a cell, creating a detectable 'fingerprint' of cancer.



Chip-based blood test for multiple myeloma could make bone biopsies a relic of the past

Thu, 19 Apr 18 00:11:40 -0700

A University of Kansas research effort has resulted in a low-cost, reliable blood test that uses a small plastic chip about the size of a credit card that can deliver the same diagnostic information as a bone biopsy -- but using a simple blood draw instead.



Study may explain why some triple-negative breast cancers are resistant to chemotherapy

Thu, 19 Apr 18 00:12:50 -0700

Triple-negative breast cancer (TNBC) is an aggressive form of the disease accounting for 12 to 18 percent of breast cancers. It is a scary diagnosis, and even though chemotherapy can be effective as standard-of-care, many patients become resistant to treatment. A team at The University of Texas MD Anderson led a study which may explain how resistance evolves over time, and potentially which patients could benefit from chemotherapy.



Landmark study links tumor evolution to prostate cancer severity

Thu, 19 Apr 18 00:12:40 -0700

Findings from Canadian Prostate Cancer Genome Network (CPC-GENE) researchers and their collaborators, published today in Cell, show that the aggressiveness of an individual prostate cancer can be accurately assessed by looking at how that tumor has evolved. This information can be used to determine what type and how much treatment should be given to each patient, or if any is needed at all.



Vitamin D deficiency linked to greater risk of diabetes

Thu, 19 Apr 18 00:02:20 -0700

An epidemiological study conducted by researchers at University of California San Diego School of Medicine and Seoul National University suggests that persons deficient in vitamin D may be at much greater risk of developing diabetes. The findings are reported April 19 in PLOS One.



Scientists identify 170 potential lung cancer drug targets using unique cellular library

Thu, 19 Apr 18 00:02:50 -0700

After testing more than 200,000 chemical compounds, UT Southwestern's Simmons Cancer Center researchers have identified 170 chemicals that are potential candidates for development into drug therapies for lung cancer.



Improved method of delivering anti-cancer drugs

Wed, 18 Apr 18 00:16:20 -0700

A new non-toxic method for delivering anti-cancer drugs to specific parts of the human body could mean the end of the severe and nasty side effects associated with many cancer therapies, according to researchers at Cardiff University's School of Pharmacy and Pharmaceutical Sciences.



Three solutions to maximize the clinical benefit and affordability of targeted cancer drugs

Wed, 18 Apr 18 00:03:00 -0700

A group led by the Abramson Cancer Center of the University of Pennsylvania has proposed three solutions to maximize the clinical benefit and affordability of targeted cancer drugs.



An artificial mole as an early warning system

Wed, 18 Apr 18 00:10:40 -0700

ETH researchers working with Martin Fussenegger have developed an early warning system for the four most common types of cancer. Should a tumor develop, a visible mole will appear on the skin.



Researchers identified a protein associated with breast cancer

Wed, 18 Apr 18 00:12:20 -0700

Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.



Diagnosing, treating neuropathy symptoms in cancer patients not exact science

Tue, 17 Apr 18 00:07:10 -0700

Most of the roughly 15.5 million cancer survivors in the US receive chemotherapy, and roughly 65 percent develop some degree of the chemotherapy-induced nerve damage known as peripheral neuropathy.



Combination therapy strengthens T cells in melanoma pre-clinical study

Tue, 17 Apr 18 00:08:10 -0700

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN. The study was led by investigators at The University of Texas MD Anderson Cancer Center.



Scientists find some human cancers to be 'evolutionary accidents'

Tue, 17 Apr 18 00:11:40 -0700

New research, published in Biological Reviews and conducted by researchers from the University of Liverpool and Escola Superior de Ciências da Saúde (Brasília, Brazil) has found some type of cancers unique to humans may be a result of evolutionary accidents.



A new, streamlined approach to diagnosing and treating bowel cancer

Tue, 17 Apr 18 00:13:50 -0700

Researchers at the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide have discovered a faster, more cost-effective way to determine which DNA mutations cause human bowel cancer.



Study reports possible novel method for stopping untreatable pediatric brain cancers

Tue, 17 Apr 18 00:12:40 -0700

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists report in the journal Molecular Cancer Therapeutics testing the small molecule 6-thio-2'deoxyguanosine (6-thio-dG) in brain cancer stem cells derived from tumor cells donated by patients. Researchers also tested the treatment in humanized mouse models of pediatric brain cancer.



PharmaMar discovers new data on the mechanism of action of plitidepsin in tumor cells

Tue, 17 Apr 18 00:16:30 -0700

PharmaMar (MSE: PHM) has presented during the AACR meeting (American Association for Cancer Research) in Chicago new data about how plitidepsin works on the tumor cells.



FDA approves new standard of care for kidney cancer

Tue, 17 Apr 18 00:01:40 -0700

The US Food and Drug Administration granted approval to the combination of two immunotherapy drugs, ipilimumab and nivolumab, for the treatment of metastatic kidney cancer.



Global ROS1 initiative: A patient-researcher collaboration targeting ROS1 cancer

Tue, 17 Apr 18 00:04:20 -0700

CU presentation at AACR2018 describes the first research-focused group of patients organized around the genetic mutation that creates their cancer, namely changes to the gene ROS1.



For aggressive breast cancer in the brain, researchers clarify immune response

Tue, 17 Apr 18 00:04:50 -0700

In a preliminary study presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers from the UNC Lineberger Comprehensive Cancer Center revealed findings for what kind of immune response the body is staging against triple negative breast cancer that has spread to the brain. They hope they can use these findings to improve patient responses to drugs that work by unleashing the immune system against cancer.



Gene mapping lays groundwork for precision chemotherapy

Tue, 17 Apr 18 00:06:20 -0700

Despite the great successes of targeted cancer drugs and the promise of novel immunotherapies, the vast majority of people diagnosed with cancer are still first treated with chemotherapy. Now a new study by UCSF researchers using techniques drawn from computational biology could make it much easier for physicians to use the genetic profile of a patient's tumor to pick the chemotherapy treatment with the fewest side effects and best chance of success.



Study examines maternal metabolic factors and early-onset puberty

Mon, 16 Apr 18 00:02:10 -0700

In a study of more than 15,000 girls and their mothers -- all Kaiser Permanente members in Northern California -- maternal overweight and hyperglycemia were linked to the earlier onset of puberty in girls 6 to 11 years old. Early puberty has been linked to multiple adverse health developments as girls grow up.



New study discovers cancer-relevant protein shield

Mon, 16 Apr 18 00:08:10 -0700

Researchers from the Novo Nordisk Foundation Center for Protein Research have uncovered a new protein shield that aids in repairing damaged DNA in cells and affects resistance to drugs used for breast cancer treatment. The new study has just been published in the internationally acclaimed scientific journal Cell.



Scientists create technology that measures tumors' drug resistance up to 10 times faster

Mon, 16 Apr 18 00:12:30 -0700

A group of scientists from VCU Massey Cancer Center and UCLA Jonsson Comprehensive Cancer Center have developed a new, high-speed microscopy platform that can measure a cancer cell's resistance to drugs up to 10 times faster than existing technology, potentially informing more effective treatment selection for cancer patients. The technology is being presented in abstract form today at the American Association for Cancer Research's Annual Meeting in Chicago.



When prostate cancer reaches bone, bone cells may drive overall growth of the disease

Mon, 16 Apr 18 00:14:50 -0700

When prostate cancer metastasizes to bone, it can become especially dangerous. A CU study at AACR18 hints at why: cells involved in these bone metastases may release signals that drive the progression of the disease.



Study examines accuracy of test for lymph node metastases in women with breast cancer

Mon, 16 Apr 18 00:15:30 -0700

A new BJS (British Journal of Surgery) study indicates that axillary ultrasound imaging is inferior for detecting axillary node metastasis in patients with breast cancer.



Three-fold higher risk of cancer after acute thrombosis in the leg

Mon, 16 Apr 18 00:16:20 -0700

The risk of developing cancer is more than three times higher during the first six months following blood clot in the leg, compared with the background population. This is shown by a register-based study that medical doctor and Ph.D. Jens Sundbøll has recently published in the journal Circulation. Jens Sundbøll is employed at the Department of Clinical Epidemiology, which is part of the Department of Clinical Medicine at Aarhus University and Aarhus University Hospital.



Is whole-brain radiation still best for brain metastases from small-cell lung cancer?

Mon, 16 Apr 18 00:02:40 -0700

University of Colorado Cancer Center study compares outcomes of 5,752 small-cell lung cancer patients who received whole-brain radiation therapy (WBRT) with those of 200 patients who received stereotactic radiosurgery (SRS), finding that the median overall survival was actually longer with SRS (10.8 months with SRS versus 7.1 months with WBRT).



Man-made antibodies show promise in attacking cancer cells in animal models

Mon, 16 Apr 18 00:04:30 -0700

Using chemotherapy along with aptamers -- lab-made molecules that function like antibodies -- Duke Health researchers showed that they can zero in on and kill prostate cancer tumors in mice while leaving healthy tissue unscathed.



First-in-human clinical trial of new targeted therapy drug reports promising responses for multiple

Sun, 15 Apr 18 00:16:20 -0700

A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known as RET. The drug appears to be promising as a potential therapy for RET-driven cancers, such as medullary and papillary thyroid, non-small cell lung, colorectal and bile duct cancers, which have been historically difficult to treat.



Penn study finds relationship between PTEN loss, potential for immune response in BRCA 1/2-deficient ovarian cancer

Sun, 15 Apr 18 00:05:10 -0700

he protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop. Now a new study from the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania shows PTEN may serve as a marker for whether a patient with BRCA 1-2 deficient ovarian cancer is likely to respond to checkpoint inhibitor therapy.