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Preview: Brightsurf Science News :: Immunology News

Immunology Current Events and Immunology News from Brightsurf

Immunology Current Events and Immunology News Events, Discoveries and Articles from Brightsurf

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Western diet depletes artery-protecting immune cells

Tue, 20 Mar 18 00:10:00 -0700

New research from scientists at the La Jolla Institute shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate atherosclerotic plaque buildup that occurs in cardiovascular disease. The team has also found that high density lipoproteins (HDL)--more commonly known as

How allergens trigger asthma attacks

Mon, 19 Mar 18 00:11:50 -0700

A team of Inserm and CNRS researchers from the Institute of Pharmacology and Structural Biology -- or IPBS -- have identified a protein that acts like a sensor detecting various allergens in the respiratory tract responsible for asthma attacks. Their study, codirected by Corinne Cayrol and Jean-Philippe Girard, is published in Nature Immunology on March 19, 2018. These scientists' work offers hope for breakthroughs in the treatment of allergic diseases.

Pregnant women and new moms still hesitant to introduce peanut products

Mon, 19 Mar 18 00:00:10 -0700

In January 2017 guidelines were released urging parents to begin early introduction of peanut-containing foods to reduce the risk of peanut allergy. A new study shows those who are aware of the guidelines are still hesitant to put them into place and not everyone has heard of them.

Obesity and health problems: New research on a safeguard mechanism

Fri, 16 Mar 18 00:06:20 -0700

Obesity and health problems: Researchers at Maisonneuve-Rosemont Hospital in Montreal shed light on a safeguard mechanism.

New imaging approach offers unprecedented views of staph infection

Wed, 14 Mar 18 00:09:10 -0700

Eric Skaar, Ph.D., M.P.H., and colleagues at Vanderbilt have combined multiple types of molecular imaging to probe an invasive Staphylococcus aureus infection in the mouse. Their integrated imaging approach, reported this week in Science Translational Medicine, revealed new insights about staph infections and can be broadly applied to any health or disease state.

Mesenchymal stem cell therapy: Holding promise for feline inflammatory diseases

Tue, 13 Mar 18 00:00:10 -0700

Stem cell therapy is acknowledged as having great potential for the treatment of a variety of diseases in both people and animals. The use of bone marrow-derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow- and adipose-derived stem cells are being evaluated

Researcher creates 'Instagram' of immune system, blending science, technology

Fri, 09 Mar 18 00:01:40 -0800

Hollings Cancer Center researcher Carsten Krieg, Ph.D., who recently joined the faculty of the Medical University of South Carolina, uses a machine aptly labeled Helios to create a sort of 'Instagram' of a person's immune system. Krieg's work was recently published in Nature Medicine, looking at the prediction of response to immunotherapy in melanoma patients.

New molecular target could help ease asthma

Wed, 07 Mar 18 00:08:10 -0800

Researchers at UC Davis Health and Albany Medical College have shown that the protein vascular endothelial growth factor A -- or VEGFA -- plays a major role in the inflammation and airway obstruction associated with asthma. The finding may eventually lead to new asthma treatments targeting VEGFA.

Discovery fills gap in search for better treatments for Ebola, other viruses

Wed, 07 Mar 18 00:12:20 -0800

University of Alberta researchers have found the Ebola polymerase (enzyme), which may lead to more effective research and better treatments for the often fatal infection, and other related viral diseases.

UC Davis researchers find new way to defeat HIV latency

Wed, 07 Mar 18 00:09:10 -0800

Researchers at UC Davis Health, together with colleagues at UC San Francisco and the University of North Carolina at Chapel Hill, have found a mechanism for making HIV come out of hiding and become susceptible to anti-HIV drugs. Their study is published in The Journal of Clinical Investigation.

A new tactic for eczema?

Tue, 06 Mar 18 00:14:10 -0800

Existing treatments for eczema, which affects about 17 percent of children in developed countries, are expensive or have side effects. A study in Science Immunology suggests a different approach to eczema, one that stimulates a natural brake on the allergic attack, made by T regulatory cells in the skin.

Mosquito gut may hold the key to preventing Dengue and Zika

Tue, 06 Mar 18 00:14:50 -0800

A mosquito's ability to replicate and transmit a virus depends on the metabolic environment of tissues in its midgut: the primary site of infection. By targeting the sphingolipid pathway, which links together several pathways important for cell signaling and subcellular structure that are altered by virus infection, researchers could devise strategies that stall viral replication in the mosquito and prevent its transmission to humans.

The factors that most affect our immune system

Wed, 28 Feb 18 00:02:40 -0800

Why do we respond differently to infections or vaccines? The Milieu Intérieur Laboratory of Excellence coordinated at the Institut Pasteur by CNRS research director, Dr. Lluis Quintana-Murci, has recently described immune variation on a large scale within the French population. To achieve this, the consortium studied an expansive collection of biological specimens from 1,000 French volunteers aged 20 to 69. This article provides an account of their work.

Causing inflammation to run out of fuel

Thu, 22 Feb 18 00:00:10 -0800

Inflammation needs energy: An important source for this energy is oxygen, which is indispensable for the cells of the immune system to work properly. On the one hand, oxygen is an essential element required for cells to survive; on the other hand, it also adds fuel to the fire of inflammation. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have discovered that the body skilfully uses this process to extinguish inflammation.

'Icebreaker' protein opens genome for t cell development, Penn researchers find

Tue, 20 Feb 18 00:16:00 -0800

Researchers describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in developing new therapies using epigenetic drugs to alter T-cell fate in cancer, autoimmune disorders, and infectious diseases.

MicroRNA could help treat cancer and asthma

Tue, 20 Feb 18 00:05:00 -0800

MiR-223 shows promise for treating inflammatory disease.

Infection site affects how a virus spreads through the body

Mon, 19 Feb 18 00:04:40 -0800

A person is more likely to get infected by HIV through anal intercourse than vaginal, but no one knows quite why. A new study by scientists at the Gladstone Institutes shows that infection sites could affect the immune system's response to a virus and the way the virus spreads through the body.

Immune signature predicts asthma susceptibility

Fri, 16 Feb 18 00:15:40 -0800

Asthma is a chronic inflammatory disease driven by the interplay of genetics, environmental factors and a diverse cast of immune cells. In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.

Gut bacteria: It can be good, and bad, for health

Thu, 08 Feb 18 00:09:40 -0800

A new study found that impairing a rare group of cells (called Paneth cells) in the small intestine allows gut bacteria to invade the organ and cause major inflammation. The study was conducted in mice, but has implications for the treatment of inflammatory bowel disease (IBD), a group of disorders characterized by chronic inflammation in the digestive track.

How viruses disarm the immune system

Mon, 05 Feb 18 00:16:00 -0800

How do viruses that cause chronic infections, such as HIV or hepatitis c virus, manage to outsmart their hosts' immune systems? The answer to that question has long eluded scientists, but new research from McGill University has uncovered a molecular mechanism that may be a key piece of the puzzle. The discovery could provide new targets for treating a wide range of diseases.

Guidelines support telemedicine as an effective tool for allergists

Wed, 24 Jan 18 00:12:00 -0800

A position paper by the American College of Allergy, Asthma and Immunology provides guidance to allergists interested in providing telemedicine care to their patients.

Novel genomic tools provide new insight into human immune system

Fri, 19 Jan 18 00:05:50 -0800

La Jolla Institute researchers provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design to protect against chronic viral infections such as cytomegalovirus, HIV, and hepatitis C.

Cellular mechanism for severe viral hepatitis identified

Thu, 18 Jan 18 00:12:40 -0800

KAIST medical scientists identified a cellular mechanism causing inflammatory changes in regulatory T cells that can lead to severe viral hepatitis. Research on this mechanism will help further understand the nature of various inflammatory diseases and lead to the development of relevant clinical treatments.

NIH scientists find microbes on the skin of mice promote tissue healing, immunity

Thu, 18 Jan 18 00:04:40 -0800

Beneficial bacteria on the skin of lab mice work with the animals' immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues. The study was published online today in Cell.

Zika virus damages placenta, which may explain malformed babies

Thu, 18 Jan 18 00:03:50 -0800

New researcher shows how Zika virus infection in five pregnant rhesus monkeys caused placental tissues to become thickened and inflamed, resulting in less oxygen being transported across the placenta and to the baby.

Memory loss from West Nile virus may be preventable

Tue, 16 Jan 18 00:00:20 -0800

More than 10,000 people in the United States are living with memory loss and other persistent neurological problems that occur after West Nile virus infects the brain. Now, a new study in mice suggests that such ongoing neurological deficits may be due to unresolved inflammation that hinders the brain's ability to repair damaged neurons and grow new ones. When the inflammation was reduced by treatment with an arthritis drug, the animals' ability to learn and remember remained sharp after West Nile disease.

LJI researchers discover key driver of atopic dermatitis

Tue, 16 Jan 18 00:10:00 -0800

Severe eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that is driven by an allergic reaction. In their latest study, researchers at La Jolla Institute reveal an important player that promotes skin inflammation in atopic dermatitis and the characteristic thickening of the skin.

Preventing and treating acute chest syndrome in children with sickle cell disease

Fri, 05 Jan 18 00:11:30 -0800

Acute chest syndrome (ACS), a potentially severe lung complication of sickle cell disease, increases a child's risk of respiratory failure, chronic lung disease, and prolonged hospitalization if not recognized early and treated effectively.

Immune response to Zika virus contributes to fetal harm

Fri, 05 Jan 18 00:14:20 -0800

The same proteins that mount a potent immune response to Zika viral infection can also harm the placenta and fetal development, according to a Yale-led study published in Science Immunology.

New Atopic Dermatitis Yardstick provides practical guidance and management insights

Thu, 04 Jan 18 00:15:30 -0800

A newly published Atopic Dermatitis (AD) Yardstick from the American College of Allergy, Asthma and Immunology has practical recommendations for physicians about the treatment of AD.

Precision editing of gut bacteria: Potential way to treat colitis

Thu, 04 Jan 18 00:02:40 -0800

UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis.

Duke-led team develops more accurate tool to track new HIV infections

Thu, 21 Dec 17 00:13:00 -0800

Researchers at the Duke Human Vaccine Institute have led an effort to develop a more accurate way to gauge the incidence of HIV infections in large populations, which will improve research and prevention strategies worldwide.

MGH team engineers anti-inflammatory antibodies that may treat autoimmune disease

Thu, 21 Dec 17 00:04:10 -0800

A team of Massachusetts General Hospital investigators has found a way to engineer antibodies within an organism, converting autoantibodies that attack 'self' tissues into anti-inflammatory antibodies in animal models of two autoimmune diseases.

Guidelines say no special precautions needed for flu shots for people allergic to eggs

Tue, 19 Dec 17 00:07:10 -0800

An updated practice parameter from the Joint Task Force on Practice Parameters stresses that people with egg allergy should receive their yearly flu shot, and that no special precautions are required.

Immune cells in the uterus help nourish fetus during early pregnancy

Tue, 19 Dec 17 00:01:40 -0800

Natural killer cells are among the most abundant immune cells in the uterus during the first trimester of pregnancy, but their numbers decline substantially after the placenta forms. An Immunity study shows that this cell population helps to optimize maternal nourishment of the fetus at early stages of development. The researchers identified uterine natural killer cells that secrete growth-promoting factors, and demonstrated that transfer of these cells can reverse impaired fetal growth in pregnant mice.

Bioengineers imagine the future of vaccines and immunotherapy

Thu, 14 Dec 17 00:14:00 -0800

In the not-too-distant future, nanoparticles delivered to a cancer patient's immune cells might teach the cells to destroy tumors. A flu vaccine might look and feel like applying a small, round Band-Aid to your skin. These are examples of how innovative biomaterials could enhance vaccines against HIV and other infectious diseases and immunotherapies for patients with cancer or dampen responses in autoimmune disorders, allergies and transplanted organ recipients. A review appears in Trends in Immunology.

Cellular self-digestion process triggers autoimmune disease

Wed, 13 Dec 17 00:04:40 -0800

Autophagy allows cells to degrade and recycle their cellular components. Researchers at UZH have now demonstrated that the autophagy machinery in certain immune cells leads to the immune system attacking the central nervous system. The researchers are using these findings as a basis to look into new approaches to treating autoimmune diseases such as multiple sclerosis.

Memory T cells responsible for long-term immunity have been cross-trained

Wed, 13 Dec 17 00:04:10 -0800

St. Jude Children's Research Hospital and Emory University research offers insight into origins of the T cells that provide enduring immune protection; findings should aid vaccine development and cancer immunotherapies.

Single-dose vaccine could provide faster protection in cholera epidemics

Mon, 11 Dec 17 00:12:50 -0800

Each year there are more than three million cases of cholera worldwide. Research at the University of Maryland School of Medicine now shows that giving a stronger single-dose of a live oral vaccine could be an effective tool in controlling outbreaks more quickly.

Polyunsaturated fatty acids linked to reduced allergy risk

Tue, 05 Dec 17 00:02:00 -0800

New research from Karolinska Institutet in Sweden reveals that high levels of polyunsaturated fatty acids in children's blood are associated with a reduced risk of asthma or rhinitis at the age of 16 years. The study is published in The Journal of Allergy and Clinical Immunology.

Scientists find potential weapons for the battle against antibiotic resistance

Tue, 05 Dec 17 00:05:10 -0800

UNC School of Medicine scientists found that the bacterium Pseudomonas aeruginosa can produce specific molecular factors that dramatically increase or decrease an antibiotic's ability to kill Staphylococcus aureus, another bacterium that often co-infects with P. aeruginosa. The findings, published in PLoS Biology, point to the possibility of new antibiotics employing these factors to enhance antibiotic susceptibility.

Immune-boosting antibody combination could improve lymphoma survival

Thu, 30 Nov 17 00:01:30 -0800

Combining two different immunotherapy treatments could dramatically improve lymphoma survival, according to a Cancer Research UK funded study published in Cancer Cell today (Thursday).

Scientists identify key factors that help microbes thrive in harsh environments

Mon, 27 Nov 17 00:09:40 -0800

Three new studies by University of Maryland School of Medicine scientists have identified key factors that help microbes survive in harsh environments.

Researchers show stress suppresses response to cancer treatments

Wed, 22 Nov 17 00:15:50 -0800

New research shows that chronic stress suppresses the immune system's response to cancer, reducing the effectiveness of immunotherapy treatments. University of Queensland scientists say they are investigating dual therapies for patients to reduce stress signalling and improve their response to treatments. UQ Diamantina Institute researcher Dr. Stephen Mattarollo said lymphoma progressed more rapidly in mouse models when stress pathways were induced to reflect chronic psychological stress.

How a poorly explored immune cell may impact cancer immunity and immunotherapy

Fri, 17 Nov 17 00:13:20 -0800

The immune cells that are trained to fight off the body's invaders can become defective. It's what allows cancer to develop. So most research has targeted these co-called effector T-cells. But a new study takes a step back and considers: What if the problem isn't with the effector T-cells but starts higher up the cellular chain?

Clinicians need a clear definition of severe asthma for precise management

Tue, 14 Nov 17 00:09:30 -0800

An article in the Annals of Allergy, Asthma and Immunology, guides medical professionals through the principles involved in using these new treatments for severe asthma.

Russian chemists developed a way to synthesize drugs from renewable precursors

Tue, 14 Nov 17 00:07:20 -0800

The scientists of RUDN University together with their Russian colleagues have developed a new approach to the synthesis of benzofurans from cheap raw materials. Original furans can be produced from wastes of agriculture and wooworking industry, such as sawdust, cobs and other by-products of crop production. The results of the work were described in the article published in Tetrahedron.

Dengue immunity can protect against Zika virus

Mon, 13 Nov 17 00:04:40 -0800

A study published the Nov. 13, 2017, issue of Nature Communications by La Jolla Institute for Allergy and Immunology (LJI) investigator Sujan Shresta, Ph.D., now addresses interplay between dengue and ZIKV infections. It reports that mice rendered immune to dengue show 'cross-protection' from subsequent Zika infection and then identifies specific types of immune T-cells capable of defending against both viruses. These revelations have profound implications for efforts to build a potent anti-Zika vaccine.

Breastfeeding does not protect children against asthma and allergies

Mon, 13 Nov 17 00:13:10 -0800

The effect of breastfeeding on the risk of developing asthma and allergy has been debated for a long time. In a recent study, Uppsala University researchers show that breastfeeding might in fact increase the risk of developing hay fever and eczema, while not having any clear effect on the risk of asthma. The results have been published in the Journal of Allergy and Clinical Immunology.

Two meds not always better than one for seasonal allergic rhinitis

Tue, 07 Nov 17 00:03:20 -0800

In a newly updated clinical practice guideline, published in Annals of Allergy, Asthma and Immunology, allergists offer practical advice on the best types and amounts of medications to treat seasonal allergic rhinitis.