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Preview: Brightsurf Science News :: Gene Expression News

Gene Expression Current Events and Gene Expression News from Brightsurf

Gene Expression Current Events and Gene Expression News Events, Discoveries and Articles from Brightsurf

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Discovery of a new genetic syndrome which predisposes the body to cancer

Fri, 22 Sep 17 00:06:30 -0700

A new syndrome caused by biallelic mutations -- those produced in both gene copies inherited from the mother and father -- in the FANCM gene predisposes the body to the appearance of tumors and causes rejection to chemotherapy treatments. Contrary to what scientists believed, the gene does not cause Fanconi anaemia. Researchers recommend modifying the clinical monitoring of patients with these mutations.

Russian scientists have studied the genes that allow cancer cells to resist drugs

Fri, 22 Sep 17 00:02:30 -0700

Researchers from the People's Friendship University of Russia (RUDN University) have studied the mechanism of drug resistance for ovarian and breast cancer cells. They discovered that these cancer cells have redox-dependent mechanism which is tasked with sustaining their drug resistance. The results have been published in two articles in the journal of Free Radical Biology and Medicine.

New gene delivery approach could allow long-term persistence in proliferating cells

Fri, 22 Sep 17 00:03:20 -0700

Researchers added a scaffold/matrix attachment region (S/MAR) to a conventional adeno-associated virus (AAV) vector used for gene transfer, and the modified vectors were able to establish colonies and maintain long-term transgene expression in HeLa cells.

Usher syndrome: Gene therapy restores hearing and balance

Fri, 22 Sep 17 00:04:30 -0700

Scientists from the Institut Pasteur, Inserm, the CNRS, Collège de France, University Pierre et Marie Curie, and University Clermont Auvergne, have recently restored hearing and balance in a mouse model of Usher syndrome type 1G characterized by profound congenital deafness and vestibular disorders caused by severe dysmorphogenesis of the mechanoelectrical transduction apparatus of the inner ear's sensory cells. These findings open up new possibilities for the development of gene therapy treatments for hereditary forms of deafness.

Researchers describe mechanism that underlies age-associated bone loss

Fri, 22 Sep 17 00:08:00 -0700

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Researchers have now detailed an underlying mechanism leading to that osteoporosis. When this mechanism malfunctions, progenitor cells stop creating bone-producing cells, and instead create fat cells. Knowledge of this mechanism can provide targets in the search for novel bone-loss.

New Wayne State research findings offers hope to people with fibromyalgia

Thu, 21 Sep 17 00:10:10 -0700

A novel psychological therapy that encourages addressing emotional experiences related to trauma, conflict and relationship problems has been found helpful for people with the chronic pain condition fibromyalgia. A research team led by Mark A. Lumley, Ph.D., distinguished professor of psychology at Wayne State University, has released the results of its research in the prestigious journal, PAIN.

Researchers discover new cattle disease and prevent it from spreading

Thu, 21 Sep 17 00:02:00 -0700

Following genetic studies of deformed calves research conducted at the University of Copenhagen is able to uncover a hitherto unknown disease found among Holstein cattle. The breeding bull from which the mutation and thus the deformation originate has now been put down to prevent the disease from spreading further.

Mitochondria drive cell survival in times of need

Thu, 21 Sep 17 00:05:20 -0700

McGill University researchers have discovered a mechanism through which mitochondria, the energy factory of our body's cells, play a role in preventing cells from dying when the cells are deprived of nutrients - a finding that points to a potential target for next-generation cancer drugs.

Gene immunotherapy protects against multiple sclerosis in mice

Thu, 21 Sep 17 00:08:40 -0700

A potent and long-lasting gene immunotherapy approach prevents and reverses symptoms of multiple sclerosis in mice, according to a study published Sept. 21 in the journal Molecular Therapy. The researchers used a viral vector to deliver a gene encoding a myelin sheath protein to the liver, thereby inducing robust and durable immune tolerance in mice by preventing T cells from attacking the myelin sheath.

'Labyrinth' chip could help monitor aggressive cancer stem cells

Thu, 21 Sep 17 00:10:30 -0700

Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. It is already in use in a breast cancer clinical trial.

Unique gene therapy prevents, reverses multiple sclerosis in animal model

Thu, 21 Sep 17 00:13:40 -0700

Multiple sclerosis can be inhibited or reversed using a novel gene therapy technique that stops the disease's immune response in mouse models, University of Florida Health researchers have found.

Into more thin air

Thu, 21 Sep 17 00:13:30 -0700

Many research groups have explored human adaptation to high altitude living among three major far-flung global populations: Tibetans, Ethiopians and Peruvians. But few have simultaneously explored the other extreme---maladaptation----in the form of chronic mountain sickness (CMS). Now, in the largest whole genome study of its kind, an international research team led by University of California San Diego's Chairman of Pediatrics, Dr. Gabriel Haddad, has expanded on their recent study of understanding both adaptation extremes in a Peruvian population.

Guess who? Facial expressions can cause confusion

Wed, 20 Sep 17 00:02:50 -0700

Photos of the same person can look substantially different. For example, your passport photo may look quite different from your driving license, or your face in holiday photos. Research has shown when photos of an individual's face are judged too dissimilar to go together, people will tend to think they show several different identities. Scientists from the University of Bristol tested this concept further by exploring what happens when the photos show faces with different expressions.

Genetic risk profile predicts survival for people with severe lung disease

Wed, 20 Sep 17 00:09:20 -0700

An international Yale-led research team has shown that a risk profile based on 52 genes accurately predicts survival for patients with a severe lung disease. If confirmed in further studies, the finding could transform the way patients are treated for the condition, which is on the rise in older adults.

Alcohol use affects levels of cholesterol regulator through epigenetics

Wed, 20 Sep 17 00:13:40 -0700

In an analysis of the epigenomes of people and mice, researchers at Johns Hopkins Medicine and the National Institutes of Health report that drinking alcohol may induce changes to a cholesterol-regulating gene.

'Capicua' gene plays a key role in T-cell acute lymphoblastic leukemia

Wed, 20 Sep 17 00:03:40 -0700

Researchers at the Spanish National Cancer Research Centre have discovered a genetic alteration that is directly involved in at least 10 percent of cases of one of the most common cancers in children, T-cell acute lymphoblastic leukemia. In a paper published this week in the printed edition of Genes and Development, the scientists explain how the mice in which a specific gene, known as Capicua, has been inactivated, inevitably develop this type of leukemia.

Genome editing reveals role of gene important for human embryo development

Wed, 20 Sep 17 00:08:20 -0700

Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development. This is the first time that genome editing has been used to study gene function in human embryos, which could help scientists to better understand the biology of our early development.

Faulty cell signaling derails cerebral cortex development, could it lead to autism?

Wed, 20 Sep 17 00:10:50 -0700

As the embryonic brain develops, a complex cascade of cellular events occur, starting with progenitors -- the originating cells that generate neurons and spur proper cortex development. If this cascade malfunctions then the brain can develop abnormally. Eva Anton's lab at UNC has shown how the deletion of the protein APC in progenitor leads to massive disruption of brain development and the Wnt protein pathway, which previously was linked to genes associated with autism.

Bio-inspired approach to RNA delivery

Wed, 20 Sep 17 00:13:40 -0700

A team of MIT chemical engineers, inspired by the way that cells translate their own mRNA into proteins, has designed a synthetic delivery system that is four times more effective than delivering mRNA on its own.

Scientists find way to convert bad body fat into good fat

Tue, 19 Sep 17 00:02:20 -0700

Working in mice, researchers at Washington University School of Medicine in St. Louis have identified a way to convert white fat, which stores calories, into brown fat that burns them.

A fat-regulating enzyme could hold the key to obesity, diabetes, cancer, other diseases

Mon, 18 Sep 17 00:01:30 -0700

It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists at Rutgers University-New Brunswick have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation and other ills. Their findings were published online in the Journal of Biological Chemistry last month.

Metabolism can be used to subtype hepatoblastoma

Mon, 18 Sep 17 00:03:30 -0700

Looking at cell metabolism instead of histology, EPFL scientists have identified new biomarkers that could help more accurately classify the two main subtypes of hepatoblastoma, a children's liver cancer.

Cells programmed like computers to fight disease

Mon, 18 Sep 17 00:04:50 -0700

Cells can be programmed like a computer to fight cancer, influenza, and other serious conditions -- thanks to a breakthrough in synthetic biology by the University of Warwick.

How bacteria hinder chemotherapy

Mon, 18 Sep 17 00:06:20 -0700

Scientists find bacteria in pancreatic tumors that metabolize a common drug.

Genomic recycling: Ancestral genes take on new roles

Mon, 18 Sep 17 00:07:00 -0700

How some genes lost the ability to make proteins -- and gained regulatory powers.

Scientists show molecular basis for ants acting as 'bodyguards' for plants

Mon, 18 Sep 17 00:13:30 -0700

Though you might not think of ants as formidable bodyguards, some do an impressive job protecting plants from enemies. Examing the relationship between the Amazon rainforest plant Cordia nodosa in Peru and the ant species Allomerus octoarticulatus, University of Toronto scientists found the degree to which the ants express two genes significantly impacts the amount of protection they provide to their hosts.

New assay leads to step toward gene therapy for deaf patients

Mon, 18 Sep 17 00:15:50 -0700

Scientists at have taken an important step toward gene therapy for deaf patients by developing a way to better study a large protein essential for hearing and finding a truncated version of it.

MicroRNA helps cancer evade immune system

Mon, 18 Sep 17 00:15:40 -0700

Salk researchers discover how oxygen-deprived tumors survive body's immune response.

Biologists identify gene involved in kidney-related birth defects

Mon, 18 Sep 17 00:15:10 -0700

A team led by University of Iowa researchers has identified a gene linked to rare kidney-related birth defects. When working properly, a gene called GREB1L activates a cascade of signals that ultimately tells other genes what they need to do to create a kidney. Results published in the journal Genetics.

New study shows promise of gene therapy to treat alcoholism

Mon, 18 Sep 17 00:00:50 -0700

Researchers used gene transfer to block the expression of one of the two main enzymes that break down alcohol in the liver, leading to the accumulation in liver cells of acetaldehyde, a metabolic byproduct of ethanol.

Scientists edit butterfly wing spots and stripes

Mon, 18 Sep 17 00:03:00 -0700

An international research team working at the Smithsonian Tropical Research Institute in Panama knocked-out a single control gene in the DNA of seven different butterfly species. In the Sept. 18 Proceedings of the National Academy of Sciences early online edition, they reveal the surprising results of rewiring the WntA gene: a single gene influences the exuberant diversity of butterfly wing patterns in nature.

Study uncovers markers for severe form of multiple sclerosis
New Haven, Conn. -- Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- that may explain why some people develop progressive multiple sclerosis (MS), the most severe form of the disease. The findings, authored by researchers at Yale University, Ohio Health