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Preview: Annals of Oncology - Advance Access

Annals of Oncology Advance Access





Published: Tue, 21 Nov 2017 00:00:00 GMT

Last Build Date: Tue, 21 Nov 2017 05:47:42 GMT

 



Patients' preferences for adjuvant sorafenib after resection of renal cell carcinoma in the SORCE trial: what makes it worthwhile?

2017-11-21

Abstract
Background
We sought to determine the survival benefits that patients judged sufficient to warrant adjuvant therapy with sorafenib for 1 year, or for 3 years after resection of renal cell carcinoma (RCC) in the SORCE trial.
Methods
SORCE participants from all sites in Australia and New Zealand, and selected sites in the UK, completed a validated preferences questionnaire at months 0, 3, 15 and 42 to elicit the minimum survival benefits they judged sufficient to warrant adjuvant sorafenib for 1 year (versus observation), or for 3 years (versus 1 year). The questionnaires used reference survival times of 5 years and 15 years; and reference survival rates at 5 years of 65% and 85%.
Results
The 233 participants had a median age of 57 years (range 29 to 78) and 71% were male. For 1 year of sorafenib versus no adjuvant therapy, the median benefits in survival times judged sufficient to warrant treatment were an extra 9 months beyond 5 years and an extra 1 year beyond 15 years; the median benefit in survival rates were an extra 4% beyond 65% and an extra 3% beyond 85% at 5 years. For 3 years of sorafenib versus 1 year of sorafenib, the median benefit in survival time judged sufficient to warrant extended treatment was an extra 1 year beyond both 5 years and 15 years. Participants randomly allocated treatment with sorafenib judged larger benefits necessary than those allocated placebo. Participants’ preferences were not associated with their baseline characteristics or the interval from randomisation.
Conclusion
Most participants judged an extra year of survival necessary to warrant 1 year of adjuvant sorafenib worthwhile, and an additional year of survival to warrant extending the duration of sorafenib from 1 year to 3 years. Patients’ preferences are important in shared-decision-making.SORCE trial clinical trials number = NCT00492258



Will liquid biopsies become our fluid transition to personalized immunotherapy?

2017-11-20

ImmunotherapyPD-L1 expressionLiquid biopsyCirculating tumour cellsNon-small cell lung cancer