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RSC - Org. Biomol. Chem. latest articles



RSC - Org. Biomol. Chem. latest articles



Last Build Date: Fri, 22 Sep 2017 06:21:17 Z

Copyright: Copyright (c) The Royal Society of Chemistry
 



Enantioselective Synthesis of Spiro-oxindole-based 3,4-Dihydropyrroles via a Michael/Cyclization Cascade of 3-Aminooxindoles with 2-Enoylpyridines
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02138K, Paper
Baodong Cui, Yu Chen, Jing Shan, Lei Qin, Changlun Yuan, Yi Wang, Wen-Yong Han, Nanwei Wan, Yong-Zheng Chen
An organocatalytic and highly diastereo- and enantioselective reaction of 3-aminooxindoles with 2-enoylpyridines for the synthesis of chiral spiro[pyrrolidin-3,2'-oxindole] derivatives has been achieved. With the cinchonidine-based thiourea catalyst, the asymmetric Michael/cyclization...
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A Reevaluation of the Origin of the Rate Acceleration for Enzyme-Catalyzed Hydride Transfer.
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01652B, Review Article
John P. Richard, Tina Amyes, Archie Reyes
There is no consensus of opinion on the origin of the large rate accelerations observed for enzyme-catalyzed hydride transfer. The interpretation of recent results from studies on hydride transfer reactions...
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Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB90152F, Correction
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Chiara Lombardi, Emma Artuso, Eleonora Grandi, Marco Lolli, Francesca Spyrakis, Emanuele Priola, Cristina Prandi
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In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02281F, Paper
Atsushi Kato, Izumi Nakagome, Shinpei Nakagawa, Kyoko Kinami, Isao Adachi, Sarah F. Jenkinson, Jerome Desire, Yves Bleriot, Robert J. Nash, George W J Fleet, Shuichi Hirono
The affinity of a series of iminosugar-based inhibitors exhibiting various ring sizes toward Hex A and their essential interactions with the enzyme active site were investigated. All the Hex A-inhibiting...
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Thermoresponsive cyclodextrins with benzenesulfonamide showing tunable inhibition for carbonic anhydrase

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02171B, Communication
Apan Qian, Huang Shi, Runlang Zhu, Jiatao Yan, Wen Li, Kun Liu, Afang Zhang
A thermally induced collapse provides a switchable microenvironment to reversibly regulate enzyme activity through introducing benzenesulfonamide ligands into thermoresponsive oligoethylene glycol-modified cyclodextrins.
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Iridium-catalyzed direct C-H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01899A, Paper
Lianhui Wang, Zi Yang, Mengqi Yang, Rongyi Zhang, Changsheng Kuai, Xiuling Cui
The Ir(III)-catalyzed C-H amidation of anilines with azides is achieved, and the 2-pyrimidyl and sulfonyl moieties could be removed, offering ortho-diaminobenzenes.
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Immobilized enzymes: understanding enzyme - surface interactions at the molecular level

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01880K, Review Article
Marie Hoarau, Somayesadat Badieyan, E. Neil G. Marsh
Interactions between immobilized enzymes and supporting surfaces are complex and context-dependent and can significantly alter enzyme structure, stability and activity.
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AgOTf-catalyzed sequential synthesis of 4-isoquinolones via oxidative ring opening of aziridines and aza-Michael addition

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02167D, Paper
Siyang Xing, Hong Cui, Nan Gu, Ying Li, Kui Wang, Dawei Tian, Jiajing Qin, Qiaoyang Liu
An efficient AgOTf-catalyzed sequential reaction involving the oxidative ring-opening of aziridines by DMSO and aza-Michael addition has been developed.
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Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01455D, Paper
L. Prati, M. Mancinelli, A. Ciogli, A. Mazzanti
A series of thermally stable atropisomeric phencyclones has been successfully synthesized as ligands in new ruthenium-based enantioselective hydrogenation catalysts.
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Modulation in the acidity constant of acridine dye with cucurbiturils: stimuli-responsive pKa tuning and dye relocation into live cells

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02135F, Paper
R. Khurana, N. Barooah, A. C. Bhasikuttan, J. Mohanty
Cucurbit[7/8]uril-acridine complexes result in striking modulation of the excited state properties of acridine and allowed a tunable upward pKa shift, which is applied for controlled relocation of the dye from the host to live cells.
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Copper Promoted N-Alkylation of Sulfoximines Using Alkylboronic acid Under Mild Condition
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02234D, Communication
Surabhi Gupta, Priyanka Chaudhary, Muniyappan Nalluchamy, Sabiah Shahul Hameed, Jeyakumar Kandasamy
Copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild condition. The optimized condition was also found...
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Synthetically useful variants of industrial lipases from Burkholderia cepacia and Pseudomonas fluorescens
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01823A, Paper
Kazunori Yoshida, Masakazu Ono, Takahiro Yamamoto, Takashi Utsumi, Satoshi Koikeda, Tadashi Ema
Industrial enzymes called lipase PS (LPS) and lipase AK (LAK), which originate from Burkholderia cepacia and Pseudomonas fluorescens, respectively, are synthetically useful biocatalysts. To strengthen their catalytic performances, we introduced...
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Chiral triptycene-pyrene [small pi]-conjugated chromophores with circularly polarized luminescence
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02046E, Paper
Tomoyuki Ikai, Yuya Wada, Seiya Awata, Changsik Yun, Katsuhiro Maeda, Motohiro Mizuno, Timothy M Swager
A pair of optically pure triptycene derivatives ((R,R)- and (S,S)-3) containing fluorescent pyrene-based [small pi]-conjugated pendant groups attached through amide spacers were prepared via a resolution step using chiral high-performance liquid...
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Nonmetallic Carbon Monoxide Releasing Molecules (CORMs)
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01674C, Review Article
Nawodi Abeyrathna, Kenyatta Washington, Chris A Bashur, Yi Liao
Carbon monoxide (CO) is a gasotransmitter that plays important roles in regulating cell functions and has shown therapeutic effects in clinic studies. CO releasing molecules (CORMs), which allow controlled release...
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A versatile platform for adding functional properties to amyloid fibrils

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02042B, Communication
Devon F. A. Fontaine, Valerie A. Ivancic, Michael B. Reardon, Noel D. Lazo, Charles E. Jakobsche
Molecular design and synthesis of a new family of bifunctional organic molecular tools for medical, nanotechnology, and structural-biology applications.
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Synthesis and photophysical properties of a bichromophoric system hosting a disaccharide spacer

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01764B, Paper
T. Papalia, A. Barattucci, S. Campagna, F. Puntoriero, T. Salerno, P. Bonaccorsi
The synthesis of an efficient energy donor-acceptor system is reported, together with its photophysical properties.
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Oxidative functionalisation of alcohols and aldehydes via the merger of oxoammonium cations and photoredox catalysis

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02243C, Paper
Jyoti Nandi, John M. Ovian, Christopher B. Kelly, Nicholas E. Leadbeater
The merger of oxoammonium cation mediated oxidation with visible-light photoredox catalysis is demonstrated in the oxidative amidation of aldehydes and alcohols.
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Regioselective oxidative cross-coupling of benzo[d]imidazo[2,1-b]thiazoles with styrenes: a novel route to C3-dicarbonylation

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Org. Biomol. Chem., 2017, 15,7696-7704
DOI: 10.1039/C7OB01778B, Paper
Siddiq Pasha Shaik, Faria Sultana, A. Ravikumar, Satish Sunkari, Abdullah Alarifi, Ahmed Kamal
Iodine promoted metal-free domino protocol has been developed for the C3-dicarbonylation of benzo[d]imidazo[2,1-b]thiazoles (IBTs) with styrenes via oxidative cleavage of the C(sp2)-H bond, followed by C3-nucleophilic attack of IBT and oxidation.
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Synthesis of the fungus metabolite cladosin C

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Org. Biomol. Chem., 2017, 15,7672-7677
DOI: 10.1039/C7OB01795B, Paper
David Linder, Rainer Schobert
Cladosin C was built up in ten steps comprising an N-acylation of dehydrovaline with a functionalised thioester, a Dieckmann cylisation, and an OH [implies] NH2 exchange with 2,4-dimethoxybenzylamine.
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Synthetic approach to tailored physical associations in peptide-polyurea/polyurethane hybrids

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Org. Biomol. Chem., 2017, 15,7607-7617
DOI: 10.1039/C7OB01352C, Paper
L. E. Matolyak, J. K. Keum, K. M. Van de Voorde, L. T. J. Korley
Tailored physical interactions were utilized to tune hierarchical organization and mechanical response in peptide-polymer hybrids.
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Synthesis of 2-aminoBODIPYs by palladium catalysed amination

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Org. Biomol. Chem., 2017, 15,7643-7653
DOI: 10.1039/C7OB01767G, Paper
Rua B. Alnoman, Patrycja Stachelek, Julian G. Knight, Anthony Harriman, Paul G. Waddell
Palladium catalysed amination of a 2-iodoBODIPY with a range of anilines and a primary alkylamine has been used as the basis for a 'switch-on' fluorescence sensor for phosgene.
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Dye-conjugated complementary lipophilic nucleosides as useful probes to study association processes by fluorescence resonance energy transfer

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Org. Biomol. Chem., 2017, 15,7558-7565
DOI: 10.1039/C7OB01930K, Paper
M. J. Mayoral, J. Camacho-Garcia, E. Magdalena-Estirado, M. Blanco-Lomas, E. Fadaei, C. Montoro-Garcia, D. Serrano-Molina, D. Gonzalez-Rodriguez
Resonance energy transfer is used here to study the association and self-sorting events between lipophilic nucleosides in apolar aromatic solvents.
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Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

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Org. Biomol. Chem., 2017, 15,7527-7532
DOI: 10.1039/C7OB02039B, Communication
James A. Rossi-Ashton, Richard J. K. Taylor, William P. Unsworth
Three divergent procedures allow the selective generation of [small delta]-lactams, [small beta]-lactams and tetrahydropyrimidinones from common imine and carboxylic acid precursors.
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Visible-light-induced tandem cyclization of 2-alkynylanilines with disulfides: a convenient method for accessing benzothiophenes under transition-metal-free and photocatalyst-free conditions

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Org. Biomol. Chem., 2017, 15,7678-7684
DOI: 10.1039/C7OB01747B, Paper
Xiaoyu Xie, Pinhua Li, Qing Shi, Lei Wang
An efficient route to benzothiophenes via visible-light induced cyclization of 2-alkynylanilines with disulfides under transition-metal-free and photocatalyst-free conditions was developed.
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Polymeric mannosides prevent DC-SIGN-mediated cell-infection by cytomegalovirus

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Org. Biomol. Chem., 2017, 15,7660-7671
DOI: 10.1039/C7OB01569K, Paper
S. Brument, C. Cheneau, Y. Brissonnet, D. Deniaud, F. Halary, S. G. Gouin
Dextrans coated with triazolylheptylmannoside ligands block human cytomegalovirus trans-infection at picomolar polymer concentrations.
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Base-mediated diastereoselective [4 + 3] annulation of in situ generated ortho-quinone methides with C,N-cyclic azomethine imines

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Org. Biomol. Chem., 2017, 15,7513-7517
DOI: 10.1039/C7OB01783A, Communication
Jianfeng Xu, Shiru Yuan, Jingyi Peng, Maozhong Miao, Zhengkai Chen, Hongjun Ren
An efficient base-mediated [4 + 3] annulation reaction of ortho-quinone methides with C,N-cyclic azomethine imines is disclosed.
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Tandem radical cyclization to construct poly-brominated 2-oxindoles

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Org. Biomol. Chem., 2017, 15,7710-7714
DOI: 10.1039/C7OB01859B, Paper
Fengjuan Chen, Yajun Wang, Shijun Zhao, Wei Jiang, Congde Huo
A metal-free aerobic way to construct tribromomethylated poly-brominated 2-oxindoles from reaction of N-arylacrylamides with CBr4via a tandem radical cyclization process was discovered. The formation of the 1,1-dibromoolefin derivatives was also realized at higher temperature.
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Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction

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Org. Biomol. Chem., 2017, 15,7654-7659
DOI: 10.1039/C7OB01739A, Paper
Jin-Wei Yuan, Shuai-Nan Liu, Wen-Peng Mai
A copper-catalysed tandem decarboxylation/aldol reaction of simple aromatic aldehydes with 2,2-difluoro-3-oxo-3-arylpropanoic acid under mild conditions.
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Modular total syntheses of mycolactone A/B and its [2H]-isotopologue

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Org. Biomol. Chem., 2017, 15,7518-7522
DOI: 10.1039/C7OB01943B, Communication
Sarah Saint-Auret, Hajer Abdelkafi, Didier Le Nouen, Laure Guenin-Mace, Caroline Demangel, Philippe Bisseret, Nicolas Blanchard
A new synthetic blueprint of mycolactone A/B is reported, granting access to the natural product and its [2H]-isotopologue.
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Transition metal mediated carbonylative benzannulations

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Org. Biomol. Chem., 2017, 15,7490-7504
DOI: 10.1039/C7OB01000A, Review Article
Wangze Song, Stephanie A. Blaszczyk, Jitian Liu, Shuojin Wang, Weiping Tang
This review summarizes novel building blocks recently developed for transition metal-catalyzed carbonylative benzannulations.
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Oxidative C-H functionalization of N-carbamoyl 1,2-dihydroquinolines

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Org. Biomol. Chem., 2017, 15,7600-7606
DOI: 10.1039/C7OB01793F, Paper
Ziqiang Liu, Lei Chen, Jing Li, Ke Liu, Jiaqi Zhao, Mengmeng Xu, Lei Feng, Ren-zhong Wan, Wei Li, Lei Liu
A modular and efficient method for the synthesis of [small alpha]-substituted 1,2-dihydroquinolines through an oxidative C-H functionalization strategy is described.
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18O2 labeling experiments illuminate the oxidation of ent-kaurene in bacterial gibberellin biosynthesis

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Org. Biomol. Chem., 2017, 15,7566-7571
DOI: 10.1039/C7OB01819C, Paper
Raimund Nagel, Reuben J. Peters
Parallel mechanisms between independently evolved plant and bacterial ent-kaurene oxidases.
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Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)

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Org. Biomol. Chem., 2017, 15,7623-7629
DOI: 10.1039/C7OB01584D, Paper
Mykhaylo S. Frasinyuk, Wen Zhang, Przemyslaw Wyrebek, Tianxin Yu, Xuehe Xu, Vitaliy M. Sviripa, Svitlana P. Bondarenko, Yanqi Xie, Huy X. Ngo, Andrew J. Morris, James L. Mohler, Michael V. Fiandalo, David S. Watt, Chunming Liu
Cytisine-linked isoflavonoids (CLIFs) inhibit cancer cells by targeting the peroxisomal enzyme HSD17B4.
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Phosphine-catalyzed [3 + 2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonene-1,3-diones

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Org. Biomol. Chem., 2017, 15,7523-7526
DOI: 10.1039/C7OB01957B, Communication
Wenjun Luo, Haiwen Hu, Sanfei Nian, Liang Qi, Fei Ling, Weihui Zhong
A novel method for phosphine-catalyzed [3 + 2] annulation of [gamma]-substituted allenoates with succinimides was developed, which was successfully applied to the synthesis of 2-azaspiro[4.4]nonene-1,3-diones derivatives in 50-96% yield, with high regio- and diastereoselectivities.
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Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline

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Org. Biomol. Chem., 2017, 15,7509-7512
DOI: 10.1039/C7OB01726J, Communication
Jing Wu, Dadian Wang, Xiang Chen, Qingwen Gui, Hua Li, Ze Tan, Genping Huang, Guangwei Wang
A highly efficient synthesis of 4-benzylpyridines was developed via Pd-catalyzed C(sp3)-H arylation between 4-picoline and aryl halides. It was found that the best yields were achieved with a simple Pd(PPh3)4 catalyst and Cs2CO3 as the base.
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Stereodivergent Mannich reaction of bis(trimethylsilyl)ketene acetals with N-tert-butanesulfinyl imines by Lewis acid or Lewis base activation, a one-pot protocol to obtain chiral [small beta]-amino acids

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Org. Biomol. Chem., 2017, 15,7705-7709
DOI: 10.1039/C7OB01853C, Paper
Margarita Cantu-Reyes, Isabel Alvarado-Beltran, Ricardo Ballinas-Indili, Cecilio Alvarez-Toledano, Marcos Hernandez-Rodriguez
Synthesis of chiral [small beta]2,2,3-amino acids. Either Lewis acid or Lewis base promote the reaction, surprisingly, each activation afford different enantiomer.
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Controlling the photochemical reaction of an azastilbene derivative in water using a water-soluble pillar[6]arene

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Org. Biomol. Chem., 2017, 15,7618-7622
DOI: 10.1039/C7OB01441D, Paper
Danyu Xia, Pi Wang, Bingbing Shi
A host-guest system in water based on a water-soluble pillar[6]arene and an azastilbene derivative, (E)-4,4[prime or minute]-dimethyl-4,4[prime or minute]-diazoniastilbene diiodide, has been constructed. Then this water-soluble pillar[6]arene was successfully used to control the photohydration of the azastilbene derivative in water as a "protective agent".
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The effect of comb architecture on complex coacervation

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Org. Biomol. Chem., 2017, 15,7630-7642
DOI: 10.1039/C7OB01314K, Paper
Brandon M. Johnston, Cameron W. Johnston, Rachel A. Letteri, Tyler K. Lytle, Charles E. Sing, Todd Emrick, Sarah L. Perry
Complex coacervation is a widely utilized technique for effecting phase separation, though predictive understanding of molecular-level details remains underdeveloped.
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Amidinoquinoxaline N-oxides: spin trapping of O- and C-centered radicals

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Org. Biomol. Chem., 2017, 15,7685-7695
DOI: 10.1039/C7OB01387F, Paper
Nadia Gruber, Liliana R. Orelli, Roberto Cipolletti, Pierluigi Stipa
New nitrones able to trap O-/C-centered radicals forming persistent adducts whose EPR parameters depend on the trapped radicals.
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Intramolecular hydrogen bonding in conformationally semi-rigid [small alpha]-acylmethane derivatives: a theoretical NMR study

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Org. Biomol. Chem., 2017, 15,7572-7579
DOI: 10.1039/C7OB01834G, Paper
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Antonio J. Mota, Jurgen Neuhold, Martina Drescher, Sebastien Lemouzy, Leticia Gonzalez, Nuno Maulide
Experimental and computational evidence for unusual intramolecular hydrogen-bonding interactions is presented and discussed.
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Novel pyrrolobenzodiazepine and pyrroloquinazoline scaffolds synthesized by a simple and highly selective Ugi/cyclization sequence

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Org. Biomol. Chem., 2017, 15,7549-7557
DOI: 10.1039/C7OB01807J, Paper
Pablo Pertejo, Pablo Pena-Calleja, Israel Carreira-Barral, Roberto Quesada, Nicolas Alejandro Cordero, Francisco Javier Rodriguez, Maria Garcia-Valverde
A simple Ugi/cyclization sequence furnishing two novel pyrrolo-fused N-heterocycle families selectively by controlling the temperature is described.
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1,5-Electrocyclization of conjugated azomethine ylides derived from 3-formyl chromene and N-alkyl amino acids/esters

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Org. Biomol. Chem., 2017, 15,7580-7583
DOI: 10.1039/C7OB00705A, Paper
E. Pravardhan Reddy, A. Sumankumar, B. Sridhar, Y. Hemasri, Y. Jayaprakash Rao, B. V. Subba Reddy
A novel strategy has been developed for the synthesis of chromeno[3,4-b]pyrrol-4(3H)-one and substituted pyrrole derivatives. This is the first example of the preparation of highly substituted pyrrole derivatives from chromene-3-carboxaldehydes.
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Electronic effects on a one-pot aromatization cascade involving alkynyl-Prins cyclization, Friedel-Crafts alkylation and dehydration to tricyclic benzo[f]isochromenes

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Org. Biomol. Chem., 2017, 15,7584-7593
DOI: 10.1039/C7OB01412K, Paper
Robert J. Hinkle, Yuzhou Chen, Colleen P. Nofi, Shane E. Lewis
A short, efficient cyclization/aromatization cascade affords tricyclic 1,4-dihydro-2H-benzo[f]isochromenes. Electronic factors suggest concerted alkynyl-Prins and Friedel-Crafts reactions in the sequence.
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Formation of hydrazones and stabilized boron-nitrogen heterocycles in aqueous solution from carbohydrazides and ortho-formylphenylboronic acids

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Org. Biomol. Chem., 2017, 15,7543-7548
DOI: 10.1039/C7OB01708A, Paper
Han Gu, Tak Ian Chio, Zhen Lei, Richard J. Staples, Jennifer S. Hirschi, Susan Bane
A carbohydrazide possessing an [small alpha]-amino group forms a tricyclic boron-containing heterocycle that is useful for creating stable bioconjugates.
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Highly efficient one-pot assembly of peptides by double chemoselective coupling

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Org. Biomol. Chem., 2017, 15,7533-7542
DOI: 10.1039/C7OB01544E, Paper
Ivo E. Sampaio-Dias, Carlos A. D. Sousa, Sara C. Silva-Reis, Sara Ribeiro, Xerardo Garcia-Mera, Jose E. Rodriguez-Borges
An efficient and faster methodology for the assembly of oligopeptides by a three-step one-pot protocol with high yields and virtually no epimerization.
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Organocatalytic condensation-ring opening-annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins

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Org. Biomol. Chem., 2017, 15,7505-7508
DOI: 10.1039/C7OB01730H, Communication
Yuyu Cheng, Pengfei Zhang, Yanwen Jia, Zhiqiang Fang, Pengfei Li
An organocatalytic cascade synthesis of 3-arylcoumarins has been developed.
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Cu(II)-Mediated keto C(sp3)-H bond [small alpha]-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids

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Org. Biomol. Chem., 2017, 15,7594-7599
DOI: 10.1039/C7OB01190C, Paper
Wenjing Li, Changzhen Yin, Xiao Yang, Hailong Liu, Xueli Zheng, Maolin Yuan, Ruixiang Li, Haiyan Fu, Hua Chen
The first example of Cu(II)-mediated oxidative coupling of aromatic carboxylic acids with the C(sp3)-H bond adjacent to the keto group of N,N-dialkylamides has been developed.
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One-pot Synthesis of 3,5-Disubstituted 1,2,4-Thiadiazoles from Nitriles and Thioamides via I2-Mediated Oxidative Formation of N-S Bond
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01887H, Paper
Ling Chai, Yuanqing Xu, Tao Ding, Xiaomin Fang, Wenkai Zhang, Yanpeng Wang, Minghua Lu, Hao Xu, Xiaobo Yang
A simple and practical method for I2-mediated one-pot synthesis of 3-alkyl-5-aryl-1,2,4-thiadiazoles has been developed; the one-pot reaction includes sequential intermolecular addition of thioamides to nitriles, and intramolecular oxidative coupling of...
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B(C6F5)3 Catalysed reduction of para-Qunione Methides and Fuchsones to Access Unsymmetrical Diaryl- and Triarylmethanes: Elaboration to Beclobrate
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02007D, Paper
Sriram Mahesh, Vijaya Anand Ramasamy
A mild and efficient method for the synthesis of unsymmetrical diaryl- and triarylmethanes through a B(C6F5)3 catalyzed reduction of para-quinone methides and fuchsones respectively, using Hantzsch ester as a reducing...
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Mechanisms for C(sp2)-Si activation of aryltrimethylsilyl groups in palladium-catalysed couplings

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01675A, Paper
Waqar Rauf, John M. Brown
DFT reveals why arenes with an amide or anilide directing group react faster by C-Si than by C-H cleavage in Pd coupling reactions.
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RNA-directed off/on switch of RNase H activity using boronic ester formation

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02145C, Paper
Maeva Reverte, Ivan Barvik, Jean-Jacques Vasseur, Michael Smietana
A new concept to modulate RNase H activity is presented based on the boronic acid/boronate switch.
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An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01850A, Paper
S. Vichier-Guerre, L. Dugue, F. Bonhomme, S. Pochet
A versatile two-step synthesis of C4- and C5-arylated 2[prime or minute]-deoxyribosylimidazoles was elaborated by enzymatic N-transglycosylation followed by microwave-assisted Pd-catalysed arylation reactions.
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A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01771E, Paper
Yoshinori Yamamoto, Toshimasa Itoh, Keiko Yamamoto
A salt formation suppresses acyl migration of DHA lysophosphatidic acid.
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Cu/Pd Cooperatively Catalyzed Tandem C-N and C-P Bonds Formation: Access to Phosphorated 2H-Indazoles
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02323E, Paper
Weiwei Wei, Xuanyi Li, Meng Gu, Hequan Yao, Aijun Lin
A novel Cu/Pd cooperatively catalyzed tandem C-N and C-P bonds formation reaction between 2-alkynyl azobenzenes and P(O)H compounds has been developed. This reaction provides a convenient approach to the synthesis...
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Enantioselective synthesis of sterically hindered [small alpha]-allyl-[small alpha]-aryl oxindoles via palladium-catalysed decarboxylative asymmetric allylic alkylation

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02161E, Paper
Mark Jackson, Calvin Quince O'Broin, Helge Muller-Bunz, Patrick J. Guiry
The highly enantioselective synthesis of sterically hindered [small alpha]-allyl-[small alpha]-aryl oxindoles possessing an all-carbon quaternary stereocenter at the oxindole 3-position has been developed.
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The Trimerization of Acetylenes Involves a Cascade of Biradical and Pericyclic Processes
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01885A, Paper
Gavin O Jones, Zachary J Krebs
Thorough computational studies were performed on mechanisms and energies for the thermal trimerizations of neutral or electron-rich acetylenes used as cross-linkers in organic hard-masks for lithography applications. These studies indicate...
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Nazarov reaction: current trends and recent advances in the synthesis of natural compounds and their analogs
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01981E, Review Article
Maxim G. Vinogradov, Olga Turova, Sergei Grigorievich Zlotin
The Nazarov reaction (cyclization) is one of the most useful synthetic tools for the stereoselective preparation of various cyclopentenone scaffolds. This review summarizes recent applications of this reaction to the...
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The pH influenced PET processes between pyronine and different heterocycles
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02247F, Paper
Ling Yang, Jin-Yun Niu, Ru Sun, Yu-Jie Xu, Jian-Feng Ge
The OFF-ON and ON-OFF type pH probes based on rosamine were designed by relative electron densities between the pyronine and various linked heterocycles. Probe 1a with an indole-pyronine skeleton gave...
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Gold(I)-Catalyzed Synthesis of 2-Substituted Indoles from 2-Alkynylnitroarenes with Diboron as Reductant
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01918A, Paper
Wenqiang Fu, Kai Yang, Jinglong Chen, Qiuling Song
An efficient method for the synthesis of 2-substituted indoles via a diboron/base promoted tandem reductive cyclization of o-alkynylnitroarene under Au catalysis conditions has been disclosed. This reaction is efficient and...
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Synthesis and pH-dependent hydrolysis profiles of mono- and dialkyl substituted maleamic acids
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02188G, Paper
Shan Su, Fusheng Du, Zichen Li
Maleamic acid derivatives as weakly acid-sensitive linkers or caging groups have been used widely in smart delivery systems. Here we report the controlled synthetic methods to mono- and dialkyl substituted...
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Synthesis and thermal stabilities of oligonucleotides containing 2[prime or minute]-O,4[prime or minute]-C-methylene bridged nucleic acid with a phenoxazine base

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01874F, Paper
Yuki Kishimoto, Akane Fujii, Osamu Nakagawa, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika
BNAP-modified ODNs showed higher binding affinities toward complementary DNA and RNA as compared to ODNs bearing 2[prime or minute],4[prime or minute]-BNA/LNA with 5-methylcytosine or 2[prime or minute]-deoxyribonucleoside with phenoxazine.
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Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01467H, Communication
Jong-Ah Hong, Na-Eun Choi, Yeo-Kyoung La, Ho Yeon Nam, Jiwon Seo, Jiyoun Lee
A smart activity-based probe that generates a turn-on fluorescence signal in response to enzyme activity was developed, allowing dynamic imaging of subcellular enzyme activity in living cells.
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Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02163A, Communication
Xuan Feng, Nawaf Al Maharik, Axel Bartholome, Jeffrey E. Janso, Usa Reilly, David O'Hagan
Both pro-R hydroxylmethyl hydrogens of glycerol are incorporated into nucleocidin in Streptomyces calvus.
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Double 1,4-addition of (thio)salicylamides/thiosalicylic acids with propiolate derivatives: a direct, general synthesis of diverse heterocyclic scaffolds

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02101A, Communication
Hui-Hong Wang, Tao Shi, Wei-Wei Gao, Hong-Hua Zhang, Yong-Qiang Wang, Jun-Fang Li, Yong-Sheng Hou, Jin-Hong Chen, Xue Peng, Zhen Wang
A simple and practical ring-closure procedure to prepare a range of diverse heterocycles has been developed.
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Directed nucleophilic addition of phenoxides to cyclopropenes

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01785E, Paper
Pavel Yamanushkin, Michael Lu-Diaz, Andrew Edwards, Nicolai A. Aksenov, Marina Rubina, Michael Rubin
The alkali metal-templated addition of aryloxides across the double bond of non-conjugated cyclopropenes is described. High cis-selectivity is achieved through a directing effect of a strategically positioned carboxamide functionality.
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Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02126G, Communication
Deping Wang, Yanwen Zheng, Min Yang, Fuxing Zhang, Fangfang Mao, Jiangxi Yu, Xiaohong Xia
A room-temperature copper-catalyzed N-arylation of aliphatic amines with great selectivity and substrate scope tolerance in neat water has been developed.
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8-Oxo-7,8-dihydro-2`-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02096A, Paper
Aaron M Fleming, Cynthia J Burrows
In DNA, 2`-deoxyguanosine (dG) is very susceptible to oxidative modification by reactive oxygen species (ROS) yielding many products, one of which is 8-oxo-7,8-dihydro-2`-deoxyguanosine (dOG). Interestingly, dOG is stable but much...
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Photochemical Generation and Trapping of 3-Oxacyclohexyne
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01697B, Communication
Rui Fan, Yuewei Wen, Dasan Madhav Thamattoor
The strained heterocyclic alkyne, 3-oxacyclohexyne, was generated photochemically for the first time using a cyclopropanated phenanthrene precursor, and trapped by cyclopentadienones as Diels-Alder adducts. The precursor intially produced the putative...
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Structural Basis of Interstrand Cross-link Repair by O6-Alkylguanine DNA Alkyltransferase
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02093G, Paper
Alexey Denisov, Francis P McManus, Derek Kyle O'Flaherty, Anne Marietta Noronha, Christopher James Wilds
DNA Interstrand cross-links (ICL) are among the most cytotoxic lesions found in biological systems. O6-alkylguanine DNA alkyltransferases (AGTs) are capable of removing alkylation damage from the O6-atom of 2'-deoxyguanosine and...
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In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01927K, Paper
Tanja Knaus, Luca Cariati, Marcelo Fabricio Masman, Francesco G Mutti
The direct and efficient conversion of alcohols into amines is a pivotal transformation in chemistry. Here, we present an artificial, oxidation-reduction, biocatalytic network that employs five enzymes (alcohol dehydrogenase, NADP-oxidase,...
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Transition-Metal Catalyzed Divergent Functionalization of [60]Fullerene with Propargylic Esters
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02168B, Communication
Michio Yamada, Rika Ochi, Yuhei Yamamoto, Sae Okada, Yutaka Maeda
We have demonstrated that transition metal-catalyzed divergent reactions between [60]fullerene (C60) and propargylic esters allow easy access to formal [2+2] and [4+2] cycloadducts in reasonable yields, and that the production...
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Singlet oxygen-mediated one-pot chemoselective peptide-peptide ligation

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02245J, Paper
Eirini Antonatou, Yentl Verleysen, Annemieke Madder
We here describe a furan oxidation based site-specific chemical ligation approach using unprotected peptide segments.
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The spectroscopic impact of interactions with the four Gouterman orbitals from peripheral decoration of porphyrins with simple electron withdrawing and donating groups

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01960B, Paper
Angel Zhang, Lydia Kwan, Martin J. Stillman
Porphyrin [small beta]-substitution with strong electron withdrawing groups splits the LUMO, red-shifts the Q band, and introduces a dipole moment.
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Correction: Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on [small beta]-glucocerebrosidase activity
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB90148H, Correction
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Fabien Stauffert, Jenny Serra-Vinardell, Marta Gomez-Grau, Helen Michelakakis, Irene Mavridou, Daniel Grinberg, Lluisa Vilageliu, Josefina Casas, Anne Bodlenner, Antonio Delgado, Philippe Compain
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On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01489A, Paper
Germain Homerin, Emmanuelle Lipka, Benoit Rigo, Amaury Farce, Joelle Dubois, Alina Ghinet
In the current context of lack of emergence of innovative human farnesyltransferase inhibitors, and given all new therapeutic perspectives that open up for such molecules, we have just discovered a new series of powerful inhibitors with IC50 values in the nanomolar range.
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Development and applications of a near-infrared dye-benzylguanine conjugate to specifically label SNAP-tagged proteins

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01698K, Paper
Xinbo Song, Hui Bian, Chao Wang, Mingyu Hu, Ning Li, Yi Xiao
New approach to Changsha NIRs, new label to fusion proteins.
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Red-emissive triplex-forming PNA probes carrying cyanine base surrogates for fluorescence sensing of double-stranded RNA

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02077E, Communication
Toshiki Chiba, Takaya Sato, Yusuke Sato, Seiichi Nishizawa
Red-emissive fluorescent probes have been developed by integration of quinoline blue or thiazole red as the base surrogate into triplex-forming PNAs, allowing selective sensing of a sequence of double-stranded RNA.
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Palladium-catalyzed oxidative coupling of arylboronic acid with isocyanide to form aromatic carboxylic acids

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01428G, Paper
Zhen-Bang Chen, Kui Liu, Fang-Ling Zhang, Qing Yuan, Yong-Ming Zhu
A valuable palladium-catalyzed carboxylation process by using isocyanide as the carboxyl source for the synthesis of aromatic carboxylic acids from arylboronic acids has been developed.
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Synthesis of functionalized indolizines via gold(I)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02102J, Paper
Xiangdong Li, Jidong Zhao, Xin Xie, Yuanhong Liu
Gold-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes to functionalized indolizines through the construction of the pyridine ring of indolizines has been developed.
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Visible light-induced C3-sulfonamidation of imidazopyridines with sulfamides

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02029E, Paper
Yongyuan Gao, Shu Chen, Weiye Lu, Weijin Gu, Ping Liu, Peipei Sun
A visible light-induced regioselective sulfonamidation of imidazo[1,2-a]pyridines was developed using sulfamides as the nitrogen sources and aqueous NaClO solution as the oxidant under mild conditions.
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FeCl3/ZnI2-Catalyzed regioselective synthesis of angularly fused furans

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02124K, Paper
Amrita Dey, Alakananda Hajra
The FeCl3/ZnI2-catalyzed synthesis of angularly fused furans by intermolecular coupling between enols and alkynes has been developed in ambient air.
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Computational insights into active site shaping for substrate specificity and reaction regioselectivity in the EXTL2 retaining glycosyltransferase

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01937H, Paper
Fernanda Mendoza, Jose M. Lluch, Laura Masgrau
QM(DFT)/MM calculations and molecular dynamics simulations on wild-type retaining [small alpha]1,4-N-acetylhexosaminyltransferase (EXTL2) and Arg293Ala, Asp246Ala, Arg293Ala/Asp246Ala and Asp246Glu mutants are used to understand the role of these two residues.
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Copper-catalyzed oxidative cross-coupling of [small alpha]-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02012K, Paper
Chuang Chen, Menghua Zhu, Lihui Jiang, Zebing Zeng, Niannian Yi, Jiannan Xiang
A general and mild method for the construction of a carbon-nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with [small alpha]-aminocarbonyl compounds was achieved.
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Selective synthesis of tetrahydroimidazo[1,2-a]pyridine and pyrrolidine derivatives via a one-pot two-step reaction

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01860F, Paper
Yu Zhang, Jing Sun, Guo-Liang Shen, Chao-Guo Yan
In the presence of triethylamine, the addition reaction of substituted [small alpha]-amino acid alkyl esters with dialkyl but-2-ynedioate afforded active [small beta]-enamino esters, which in turn reacted with aromatic aldehydes and malononitrile to give tetrahydroimidazo[1,2-a]pyridine derivatives in moderate yields.
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Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01875D, Paper
Takeshi Inde, Yoshiaki Masaki, Atsuya Maruyama, Yu Ito, Naoaki Makio, Takahito Tomori, Yuya Miyatake, Mitsuo Sekine, Kohji Seio
To systematically understand the effect of 2-N-heteroarylguanine (GHA) modification on the stability of higher-order DNA structures, nucleoside derivatives and oligodeoxyribonucleotides containing guanine residues modified with four kinds of hereroaryl groups...
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Enantioselective Aminocatalytic Synthesis of Tetrahydropyrano [2,3-c]Pyrazoles via Domino Michael-Hemiacetalization Reaction with Alkylidene Pyrazolones
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02170D, Communication
Subhas Chandra Pan, Rajendra Maity
An enantioselective organocatalytic domino Michael-hemiacetalization reaction between alkylidene pyrazolones and cyclic ketones/pentanal has been disclosed. The fused tetrahydropyranopyrazole products having three contiguous stereocentres were obtained in perfect diastereoselectivities and in...
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Elemental Sulfur as Sulfuration Agent in Copper-Catalyzed C-H Bond Thiolation of Electron-Deficient Arenes
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02036H, Communication
Haiming Yan, Zhiliang Huang, Meng Chen, Cuiting Li, Ya Chen, Meng Gao, Aiwen Lei
By utilizing elemental sulfur as the thiolation agent and oxidant, a copper-catalyzed direct C-H bond thiolation of electron-deficient arenes was demonstrated. Various electron-deficient arenes were proved to be suitable for...
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Metal-free C-H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01999H, Communication
Mikhail V. Varaksin, Timofey D. Moseev, Oleg N Chupakhin, Valery Charushin, Boris A. Trofimov
Methodology of direct C(sp2)-H functionalization has for the first time been applied as an efficient and advanced approach to carry out C-H/С-H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical...
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Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01293D, Paper
Halley M. Menezes, Md. Jahirul Islam, Masayuki Takahashi, Nobuyuki Tamaoki
Azobenzene based non-nucleoside triphosphates, AzoTPs, drive and photo-regulate the myosin-actin motor function at both molecular and macroscopic levels.
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Deuteration and tautomeric reactivity of the 1-methyl functionality of free-base dipyrrins

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01278K, Paper
Brandon R. Groves, T. Stanley Cameron, Alison Thompson
Regioselective reactivity of the 1-methyl group of free-base dipyrrins is explored, including discussion of tautomerism to provide exocyclic alkenyl reactivity.
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Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02085F, Paper
Serena Massari, Jenny Desantis, Giulio Nannetti, Stefano Sabatini, Sara Tortorella, Laura Goracci, Violetta Cecchetti, Arianna Loregian, Oriana Tabarrini
Two facile and efficient one-step procedures for the regioselective synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidines.
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Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02045G, Paper
Tahsin F. Kellici, Maria V. Chatziathanasiadou, Min-Sung Lee, Nisar Sayyad, Elena G. Geromichalou, Eirinaios I. Vrettos, Antonis D. Tsiailanis, Seung-Wook Chi, George D. Geromichalos, Thomas Mavromoustakos, Andreas G. Tzakos
Anti-apoptotic proteins, like the Bcl-2 family proteins, present an important therapeutic cancer drug target.
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A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02095C, Paper
Nina Gerhards, Shu-Ming Li
Bifunctional FgaOx3Pr3 catalyses the formation of festuclavine in the presence of EasG or FgaFS and enhances the activity of several chanoclavine-I dehydrogenases tremendously.
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Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea

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Org. Biomol. Chem., 2017, 15,7411-7421
DOI: 10.1039/C7OB01837A, Paper
Lena Barra, Paul Barac, Gabriele M. Konig, Max Crusemann, Jeroen S. Dickschat
The volatiles released by fungi associated with the marine sponge Callyspongia cf. flammea and their bioactivities are reported.
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An ortho C-methylation/O-glycosylation motif on a hydroxy-coumarin scaffold, selectively installed by biocatalysis

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01513E, Paper
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Alexander Gutmann, Margaretha Schiller, Mandana Gruber-Khadjawi, Bernd Nidetzky
To achieve near quantitative dual modification of the hydroxy-coumarin scaffold, the C-methylation had to occur strictly before the O-glucosylation.
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One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01977G, Paper
Honggui Lv, Jingjing Shi, Bo Wu, Yujuan Guo, Junjun Huang, Wei Yi
A new and versatile Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization for one-pot synthesis of 2,3-difunctionalized indoles has been developed.
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A fluorescent pH probe for acidic organelles in living cells

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02037F, Paper
Jyun-Wei Chen, Chih-Ming Chen, Cheng-Chung Chang
The molecular design of pH sensor ADA is based on combining photoinduced electron transfer (PET) and intramolecular charge transfer (ICT). The fluorescent emission response against a pH value is suitable for probing acidic organelles in living cells.
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Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling
Org. Biomol. Chem., 2017, 15,7476-7476
DOI: 10.1039/C7OB90144E, Correction
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William D. Lambert, Samuel L. Scinto, Olga Dmitrenko, Samantha J. Boyd, Ronald Magboo, Ryan A. Mehl, Jason W. Chin, Joseph M. Fox, Stephen Wallace
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Correction: Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones
Org. Biomol. Chem., 2017, 15,7474-7475
DOI: 10.1039/C7OB90126G, Correction
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Hasan Mtiraoui, Kevin Renault, Morgane Sanselme, Moncef Msaddek, Pierre-Yves Renard, Cyrille Sabot
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Intramolecular addition of benzyl anion to alkyne utilizing [1,2]-phospha-Brook rearrangement under Bronsted base catalysis

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Org. Biomol. Chem., 2017, 15,7277-7281
DOI: 10.1039/C7OB02059G, Communication
Azusa Kondoh, Ryosuke Ozawa, Takuma Aoki, Masahiro Terada
A novel reaction system for intramolecular addition of benzyl anions to alkynes was developed by utilizing the [1,2]-phospha-Brook rearrangement under Bronsted base catalysis.
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