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RSC - Org. Biomol. Chem. latest articles



RSC - Org. Biomol. Chem. latest articles



Last Build Date: Tue, 21 Nov 2017 14:06:02 Z

Copyright: Copyright (c) The Royal Society of Chemistry
 



Direct and Highly Diastereoselective Synthesis of 3,4-Epoxy-2-Piperidones. Application to the Total Synthesis and Absolute Configurational Assignment of 3[small alpha],4[small alpha]-Epoxy-5[small beta]-Pipermethystine
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02700A, Paper
Urbano Osorio-Nieto, Laura Y Vazquez-Amaya, Herbert Hopfl, Leticia Quintero, Fernando Sartillo-Piscil
The substrate-controlled asymmetric total synthesis and absolute configurational assignment of biologically active 3,4-epoxy-5-pipermethystine, a minor component in the aerial parts of kava, has been achieved by featuring, as a key...
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Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02605F, Communication
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Pietro Dallabernardina, Colin Ruprecht, Peter James Smith, Michael G Hahn, Breeanna R Urbanowicz, Fabian Pfrengle
We report the automated glycan assembly of oligosaccharides related to the plant cell wall hemicellulosic polysaccharide xyloglucan. The synthesis of galactosylated xyloglucan oligosaccharides was enabled by introducing p-methoxybenzyl (PMB) as...
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Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02578E, Communication
Benjamin N. Atkinson, Hannah L. Woodward, James Sipthorp, Paul V. Fish
A new efficient chiral synthesis of arimoclomol is reported from (R)-(-)-glycidyl nosylate with complete retention of chiral integrity.
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Copper-catalyzed highly selective synthesis of 2-benzyl- and 2-benzylidene-substituted benzo[b]thiazinones from 2-iodophenylcinnamamides and potassium sulfide

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02585H, Communication
Wenjuan Liu, Hao Min, Xiaoming Zhu, Guobo Deng, Yun Liang
DBU as a switch could control the selectivity of the formation of 2-benzyl-substituted benzo[b]thiazinones and 2-benzylidenebenzo[b]thiazinones.
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Taking advantage of Co(II) induced enhanced VCD for the fast and sensitive determination of enantiomeric excess

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02380D, Communication
Lorenzo Arrico, Gaetano Angelici, Lorenzo Di Bari
Large Co(II)-induced VCD signals provide a method for determining the enantiomeric excess of [small alpha]-amino acids. This strategy can be followed for building new VCD protocols.
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Efficient cross-coupling of aryl/alkenyl triflates with acyclic secondary alkylboronic acids

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02531A, Paper
Tengda Si, Bowen Li, Wenrui Xiong, Bin Xu, Wenjun Tang
Efficient cross-coupling between aryl/alkenyl triflates and acyclic secondary alkylboronic acids is realized by employing P,P[double bond, length as m-dash]O ligand L1/L2, providing a series of sterically congested acyclic secondary alkyl arenes/olefins in good to excellent yields. The method has enabled a concise and 4-step synthesis of a gossypol intermediate.
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Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02374J, Paper
Din-Chi Chiu, Tzu-Chen Lin, Wen-I Huang, Ting-Jen Cheng, Keng-Chang Tsai, Jim-Min Fang
The peramivir analogue bearing a hydrophilic glycerol side chain displays 9-fold stronger inhibition against H275Y mutant than wild-type influenza virus.
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Discovery of IDO1 and DNA Dual Targeting Antitumor Agents
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02529G, Communication
Kun Fang, Shanchao Wu, Guoqiang Dong, Ying Wu, Shuqiang Chen, Jianhe Liu, Wei Wang, Chunquan Sheng
The development of small molecules for cancer immunotherapy is highly challenging and indoleamine 2,3-dioxygenase 1 (IDO1) represents a promising target. Inspired by the synergistic effects between IDO1 inhibitors and traditional...
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Synthesis of cyclopent-2-enones from furans using a nebulizer-based continuous flow photoreactor
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02557B, Communication
Georgios I. Ioannou, Tamsyn Montagnon, Dimitris Kalaitzakis, Spiros A. Pergantis, Georgios Vassilikogiannakis
A series of hydroxycyclopent-2-enones and methoxycyclopent-2-enones have been synthesized in a single operation from simple furan substrates using an innovative continuous flow nebulizer system (NebPhotOX). Photooxygenation of the furan substrates...
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One Pot Three-Component Reaction for Preparation of Dihydroquinolines with Two Different Ketones and Aromatic Amines
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02554H, Communication
Guobin Yang, Guangxun Li, Jing Huang, Zhuo Tang, Jinzhong Zhao
Three component reaction with two different ketones and aromatic amines was firstly investigated. The difference in reactivity between ordinary ketones and ketone esters allowed for the production of 1,2-DHQs efficiently....
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A novel sulfonamide non-classical carbenoid: a mechanistic study for the synthesis of enediynes

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02437A, Paper
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Theodore O. P. Hayes, Ben Slater, Richard A. J. Horan, Marc Radigois, Jonathan D. Wilden
Alkynyl sulfonamides undergo sequential 1,4- then 1,2-addition/rearrangement with lithium acetylides to yield enediynes in the absence of any promoters or catalysts. Mechanistic investigations suggest that the reaction proceeds via a novel electrophilic carbenoid with distinct reactivity compared to those previously described.
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Silver-catalyzed the decarboxylative C(sp2)-C(sp3) coupling reactions via radical mechanism
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02455J, Communication
Zhongxue Fang, Chenlong Wei, Jing Lin, Zhenhua Liu, Wei Wang, Chenshu Xu, Xuemin Wang, Yu Wang
A silver catalyzed decarboxylative C(sp2)-C(sp3) coupling of vinylic carboxylic acids with alcohols, alkylbenzenes, cycloalkanes and cyclic ethers was developed by using DTBP as an oxidant. This reaction tolerates a wide...
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Pd-Catalyzed One-Pot Sequential Cross-Coupling Reactions of Tetrabromothiophene
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02601C, Paper
Kapil Mohan Saini, Rakesh K Saunthwal, Akhilesh K. Verma
Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromo thiophene with aryl boronic acid and alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium...
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A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02569F, Communication
Michele Tavanti, Juan Mangas-Sanchez, Sarah L. Montgomery, Matthew P. Thompson, Nicholas J. Turner
Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes.
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A fluorescent combinatorial logic gate with Na+/H+-enabled OR and H+-driven low-medium-high ternary logic functions
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01828B, Paper
Jasmine Spiteri, Carl J Mallia, Glenn J Scerri, David C Magri
A novel fluorescent molecular logic gate with a 'fluorophore-spacer1-receptor1-spacer2-receptor2' format is demonstrated in 1:1 (v/v) methanol/water. The molecule consists of an anthracene fluorophore, and tertiary alkyl amine and N-(2-methoxyphenyl)aza-15-crown-5 ether...
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Conformational isomerism in cyclic peptoids and its specification
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02643A, Paper
Assunta D'Amato, ROSARIA SCHETTINI, Giorgio Della Sala, Chiara COSTABILE, Consiglia Tedesco, Irene Izzo, Francesco DE RICCARDIS
Most of the structural studies made on the secondary structure of peptoids describe their geometric attributes in terms of the classic Ramachandran plot (based on the local analysis of [small omega],...
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Synthesis of 4-Subsituted Pyrazole-3,5-diamines via Suzuki-Miyaura Coupling and Iron-Catalyzed Reduction
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02373A, Paper
Monika Tomanova, Lukas Jedinak, Jan Kosar, Lubomir Kvapil, Pavel Hradil, Petr Cankar
The general and efficient synthesis of the 4-substituted-1H-pyrazole-3,5-diamines was develop to access the derivatives with an aryl, heteroaryl, or styryl group, which are otherwise relatively difficult to prepare. The first...
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Prolonged bioluminescence imaging in living cells and mice using novel pro-substrates for Renilla luciferase
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01656E, Paper
Mingliang Yuan, Xiaojie Ma, Tianyu Jiang, Yuqi Gao, Yuanyuan Cui, Chaochao Zhang, Xingye Yang, Yun Huang, Lupei Du, Ilia V Yampolsky, Minyong Li
The prodrug or caged-luciferin strategy affords an excellent platform for persistent bioluminescence imaging. In the current work, we designed and synthesized ten novel pro-substrates for Renilla luciferase by introducing ester...
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Nitrilium Ions - Synthesis and Applications
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02533E, Review Article
Tom van Dijk, Chris Slootweg, Koop Lammertsma
Nitrilium ions are well-established in organic chemistry for many decades, but recent developments show them to be far more versatile then hitherto recognized. They are known as stable salts, can...
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Rhodium-catalyzed benzoisothiazoles synthesis by tandem annulation reactions of sulfoximines and activated olefins
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02586F, Communication
Lin Dong, Yang Li
A rhodium(III)-catalyzed N-directed ortho C-H activation reactions have been developed for the synthesis of unique heterocyclic benzoisothiazoles. Herein, the novel tandem annulation approach can efficiently construct benzoisothiazole compounds from free...
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Charged probes: turn-on selective fluorescence for RNA

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02423A, Perspective
Bahareh Shirinfar, Humaira Seema, Nisar Ahmed
Imidazolium-based charged fluorescent probes for the selective in vitro and in vivo recognition of RNA over other biomolecules.
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1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02329D, Paper
Chunhua Ma, Guojie Fan, Ping Wu, Zhi Li, Yang Zhou, Qingjie Ding, Wei Zhang
A variety of terminal alkenes were converted to the corresponding amides in yields of 25 to 86% in water via treatment with 1,3-dibromo-5,5-dimethylhydantoin, followed by reaction with molecular iodine and aq. NH3 (or amine) in one pot.
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Organocatalytic umpolung annulative dimerization of ynones for the synthesis of 5-alkylidene-2-cyclopentenones

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02424J, Communication
Dhevalapally B. Ramachary, T. Prabhakar Reddy, A. Suresh Kumar
A novel phosphine-catalyzed umpolung [3 + 2]-annulative dimerization of ynones was developed to furnish functionally rich 5-alkylidene-2-cyclopentenones.
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[small beta]-Alanine and N-terminal cationic substituents affect polyamide-DNA binding

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02513K, Paper
Beibei Liu, Shuo Wang, Karl Aston, Kevin J. Koeller, Shahrzad Fanny Hakami Kermani, Carlos H. Castaneda, M. Jose Scuderi, Rensheng Luo, James K. Bashkin, W. David Wilson
The binding preference of a systematic set of designed polyamides with [small beta]-inserts and cationic-substitutions with cognate DNA.
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Copper nitrate-catalyzed oxidative coupling of unactivated C(sp3)-H bonds of ethers and alkanes with N-hydroxyphthalimide: synthesis of N-hydroxyimide esters

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02249B, Paper
Xiaohe Xu, Jian Sun, Yuyan Lin, Jingya Cheng, Pingping Li, Yiyan Yan, Qi Shuai, Yuanyuan Xie
A novel oxygenative cross dehydrogenative coupling of ethers and alkanes with NHPI under a copper nitrate/oxygen catalytic system is described.
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A computational investigation of the solvent-dependent enantioselective intramolecular Morita-Baylis-Hillman Reaction of enones
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02025B, Paper
Nitin Kumar Singh, Bishnupada Satpathi, P Balanarayan, S. S. V. Ramasastry
The Intramolecular Morita-Baylis-Hillman reaction of [small beta]-mono and [small beta],[small beta] -disubstitued enones shows high yields and stereoselective products when the reaction is performed in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent....
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Radical fluorination reactions by thermal and photoinduced methods
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02402A, Review Article
Beatriz Lantano, Al Postigo
Radical or radical ion-based fluorination reactions of organic compounds will be presented. These methodologies include fluorination processes accomplished through thermal or photoinduced radical/electron transfer methods. In doing so, the fluorination...
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Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: Synthesis, binding studies and anti-adhesive properties
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02749D, Paper
Marion Donnier-Marechal, Nicolas Galanos, Teddy Grandjean, Yoann Pascal, Ding-Kun Ji, Lei Dong, Emilie Gillon, Xiao-Peng He, Anne Imberty, Eric Kipnis, Rodrigue Dessein, Sebastien Vidal
The synthesis of eight perylenediimide-based glycoclusters was readily performed from hexa- and tetra-propargylated cores through azide-alkyne "click" conjugation. Variations on the carbohydrate epitope (Glc, Gal, Man, Fuc) and the linker...
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Fe-catalyzed radical-type difunctionalization of styrenes with aliphatic aldehydes and trimethylsilyl azide via decarbonylative alkylation-azidation cascade
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02598J, Communication
Wei-Yu Li, Qi-Qiang Wang, Luo Yang
A convenient Fe-catalyzed decarbonylative alkylation-azidation cascade reaction of styrene derivatives with aliphatic aldehydes and TMSN3 to provide aliphatic azides is developed. With DTBP as an oxidant and radical-initiator, this reaction...
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[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition.
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02532G, Communication
Mehdi Boudjemeline, Christopher McNitt, Thomas Alan Singleton, VLADIMIR POPIK, Alexey Kostikov
A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides...
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Design and self-assembly of PBLG-b-ELP hybrid diblock copolymers based on synthetic and elastin-like polypeptides
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB01945A, Paper
Gaelle Le Fer, Delphine Portes, Guillaume Goudounet, Jean-Michel Guigner, Elisabeth Garanger, Sebastien Lecommandoux
The precision synthesis and self-assembly of amphiphilic copolypeptides containing a recombinant elastin-like polypeptide (ELP) block used as macroinitiator for the ring opening polymerization (ROP) of [gamma]-benzyl-L-glutamate ([gamma]-BLG NCA) are herein...
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Complete tetraglycosylation of a calix[4]arene by a chemo-enzymatic approach
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02448G, Paper
Silvia Bernardi, Dong Yi, Ning He, Alessandro Casnati, Wolf-Dieter Fessner, Francesco Sansone
Polyglycosylated calixarenes are efficient and selective multivalent ligands for lectins. However, the chemical decoration of these macrocyclic scaffolds with saccharides of increasing complexity is hampered by the highly complex chemistry...
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Differential array sensing for cancer cell classification and novelty detection

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02174G, Paper
Alexandra M. Gade, Margaret K. Meadows, Andrew D. Ellington, Eric V. Anslyn
A series of semi-specific peptides reported in the literature to bind various epitopes on cell surfaces were used in a differential sensing array to pattern cell line identity.
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Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02191G, Paper
M. Xu, R. Galindo-Murillo, T. E. Cheatham, R. M. Franzini
Hetero-substituted benzonorbornadiene derivatives react rapidly with tetrazines to release diverse leaving groups in high yields.
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Rational design and synthesis of a novel laterally-tetrafluorinated tricyclic mesogen with large negative dielectric anisotropy

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Org. Biomol. Chem., 2017, 15,9442-9454
DOI: 10.1039/C7OB02399E, Paper
Shigeyuki Yamada, Ken Tamamoto, Takumi Kida, Tomoyuki Asai, Takashi Ishihara, Tsutomu Konno
Laterally-tetrafluorinated tricyclic molecule was successfully developed and found to exhibit large negative dielectric anisotropy in the binary mixture.
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Functional group manoeuvring for tuning stability and reactivity: synthesis of cicerfuran, moracins (D, E, M) and chromene-fused benzofuran-based natural products

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Org. Biomol. Chem., 2017, 15,9415-9423
DOI: 10.1039/C7OB02459B, Paper
Maddali L. N. Rao, Venneti N. Murty, Sachchida Nand
The protecting group manoeuvring as a strategy was applied in tuning the stability and reactivity of substituted gem-dibromovinylphenols (12a and 22) for the domino synthesis of benzofuran-based natural products. (1-8).
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NMR-based assignment of isoleucine vs. allo-isoleucine stereochemistry

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Org. Biomol. Chem., 2017, 15,9372-9378
DOI: 10.1039/C7OB01995E, Paper
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Zoe J. Anderson, Christian Hobson, Rebecca Needley, Lijiang Song, Michael S. Perryman, Paul Kerby, David J. Fox
A simple 1H and 13C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the [small alpha]-stereocentre.
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Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point

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Org. Biomol. Chem., 2017, 15,9275-9282
DOI: 10.1039/C7OB02193C, Review Article
Tiago Rodrigues
Cheminformatics tools provide a viable means to unravel chemistry and biology in natural product space.
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Synthetic approaches to the C11-C27 fragments of bryostatins

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Org. Biomol. Chem., 2017, 15,9475-9496
DOI: 10.1039/C7OB02127E, Paper
Anthony P. Green, Simon Hardy, Eric J. Thomas
Modified Julia reactions and reactions of lithated dithianes have been used to prepare intermediates for a synthesis of bryostatins.
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Stereochemistry and mechanistic insights in the [2t + 2i + 2i] annulations of thioketenes and imines

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Org. Biomol. Chem., 2017, 15,9424-9432
DOI: 10.1039/C7OB02212C, Paper
Wei He, Junpeng Zhuang, Hongguang Du, Zhanhui Yang, Jiaxi Xu
The mechanism and stereochemistry of [2t + 2i + 2i] annulations between one thioketene molecule and two imine molecules have been studied experimentally and theoretically.
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Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10

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Org. Biomol. Chem., 2017, 15,9497-9526
DOI: 10.1039/C7OB02129A, Paper
Anthony P. Green, Simon Hardy, Alan T. L. Lee, Eric J. Thomas
The modified Julia reaction was used to assemble the (E)-16,17-double bond in the first total synthesis of a derivative of a 20-deoxybryostatin, namely 7-des-O-pivaloyl-7-O-benzylbryostatin 10.
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Structural investigation of cyclo-dioxo maleimide cross-linkers for acid and serum stability

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Org. Biomol. Chem., 2017, 15,9305-9310
DOI: 10.1039/C7OB01757J, Paper
Elisabetta Tobaldi, Igor Dovgan, Michel Mosser, Jean-Michel Becht, Alain Wagner
The size of the acetal ring and the length of the carbon chain strongly influence the serum stability of cyclo-dioxo-based amino-to-thiol coupling reagents.
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A pseudopericyclic [3,5]-sigmatropic rearrangement of a coumarin trichloroacetimidate derivative

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02335A, Communication
Trideep Rajale, Shikha Sharma, Daniel K. Unruh, Daniel A. Stroud, David M. Birney
A Woodward-Hoffmann forbidden, eight-centered transition state leads to the sole product of a pentadienyl imidate rearrangement.
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Copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates

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Org. Biomol. Chem., 2017, 15,9455-9464
DOI: 10.1039/C7OB02278F, Paper
Tao Guo, Xu-Ning Wei, Hong-Yan Wang, Ying-Li Zhu, Yun-Hui Zhao, Yong-Cheng Ma
An efficient and convenient copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates has been described.
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Electrophilic activation of aminocarboxylic acid by phosphate ester promotes Friedel-Crafts acylation by overcoming charge-charge repulsion

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Org. Biomol. Chem., 2017, 15,9398-9407
DOI: 10.1039/C7OB02158E, Paper
Akinari Sumita, Yuko Otani, Tomohiko Ohwada
o-Methyl salicylates enhance the reactivity of the phosphate ester via a protonation-induced conformational change to generate acyl phosphate, thereby overwhelming the charge-charge repulsion associated with formation of the acylium ion, enabling aromatic ketones to be generated from various carboxylic acids.
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Stereoselective annulation between an allene, an alkene, and two nitrosoarenes to access bis(isoxazoliodine) derivatives

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Org. Biomol. Chem., 2017, 15,9389-9397
DOI: 10.1039/C7OB02087B, Paper
Pankaj Sharma, Prakash D. Jadhav, Manisha Skaria, Rai-Shung Liu
This work reports metal-free annulations among one allene, two nitrosoarenes and one electron-deficient alkene to afford bis(isoxazolidine) derivatives stereoselectively.
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Azetidine-derived dinuclear zinc catalyzed asymmetric phospha-Michael addition of dialkyl phosphite to [small alpha],[small beta]-unsaturated carbonyl compounds

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Org. Biomol. Chem., 2017, 15,9465-9474
DOI: 10.1039/C7OB02222K, Paper
Shanshan Liu, Na Shao, Feng-Zhen Li, Xiao-Chao Yang, Min-Can Wang
The asymmetric phospha-Michael addition of dialkyl phosphite to [small alpha],[small beta]-unsaturated carbonyl compounds by using an azetidine-derived dinuclear zinc catalyst was described.
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Photochemical and oxidative cyclisation of tetraphenylpyrroles

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Org. Biomol. Chem., 2017, 15,9293-9296
DOI: 10.1039/C7OB02537H, Communication
Jayne L. Ferguson, Marie A. Squire, Christopher M. Fitchett
The cyclisation of tetraphenylpyrroles under complementary conditions allows controlled cyclisation giving products dependent on N-substitution, with both tandem rearrangement and halogenation being observed.
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Total syntheses of all tri-oxygenated 16-phytoprostane classes via a common precursor constructed by oxidative cyclization and alkyl-alkyl coupling reactions as the key steps

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Org. Biomol. Chem., 2017, 15,9408-9414
DOI: 10.1039/C7OB02505J, Paper
(image) Open Access
Jakub Smrcek, Radek Pohl, Ullrich Jahn
A parallel total synthesis of 16-F1t-, 16-E1-phytoprostanes and a first synthesis of 16-D1t-phytoprostanes based on a common precursor are described.
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Chemoselective N-arylation of aminobenzamides via copper catalysed Chan-Evans-Lam reactions

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Org. Biomol. Chem., 2017, 15,9288-9292
DOI: 10.1039/C7OB02491F, Communication
Shuai Liu, Weisai Zu, Jinli Zhang, Liang Xu
Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan-Evans-Lam cross-coupling with aryl boronic acids for the first time.
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Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization

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Org. Biomol. Chem., 2017, 15,9331-9351
DOI: 10.1039/C7OB02182H, Paper
Chiara Lambruschini, Denise Galante, Lisa Moni, Francesco Ferraro, Giulio Gancia, Renata Riva, Alessia Traverso, Luca Banfi, Cristina D'Arrigo
A new and short fragment-based approach towards artificial (but "natural-based") complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates.
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The iso-Nazarov reaction

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Org. Biomol. Chem., 2017, 15,9255-9274
DOI: 10.1039/C7OB02220D, Review Article
Martin J. Riveira, Lucia A. Marsili, Mirta P. Mischne
The acid-promoted cycloisomerization of conjugated dienals and linearly-conjugated dienones for the synthesis of five-membered ring systems is reviewed.
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Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues

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Org. Biomol. Chem., 2017, 15,9352-9361
DOI: 10.1039/C7OB02369C, Paper
Hao Jiang, Jing Xing, Chen Wang, Hao Zhang, Liyan Yue, Xiaozhe Wan, Wei Chen, Hong Ding, Yiqian Xie, Hongru Tao, Zhifeng Chen, Hualiang Jiang, Kaixian Chen, Shijie Chen, Mingyue Zheng, Yuanyuan Zhang, Cheng Luo
The BET family of bromodomain-containing proteins (BRDs) is believed to be a promising drug target for therapeutic intervention in a number of diseases.
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A Cu(II)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines

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Org. Biomol. Chem., 2017, 15,9311-9318
DOI: 10.1039/C7OB02014G, Paper
Yun Liu, Wenhui Wang, Junwen Han, Jinwei Sun
2-Bromo and 2-chloro imidazo[1,2-a]pyridines with different 3-aryl or alkyl groups were selectively synthesized.
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Substituent effects on stereoselectivity of dihalocarbene reactions with cyclohexadiene and on the reactivity of bis-dihalocyclopropanes in electrophilic nitrations en route to pyrimidine N-oxides

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Org. Biomol. Chem., 2017, 15,9433-9441
DOI: 10.1039/C7OB02463K, Paper
Kseniya N. Sedenkova, Elena B. Averina, Yuri K. Grishin, Julia V. Kolodyazhnaya, Victor B. Rybakov, Tamara S. Kuznetsova, Audrey Hughes, Gabriel dos Passos Gomes, Igor V. Alabugin, Nikolay S. Zefirov
Bis-adducts of cyclohexa-1,4-diene with dihalocarbenes were synthesized and investigated in heterocyclization.
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Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2[prime or minute]-triphenylene- and coronene-functionalized RNA monomers

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Org. Biomol. Chem., 2017, 15,9362-9371
DOI: 10.1039/C7OB01920C, Paper
Saswata Karmakar, Dale C. Guenther, Bradley C. Gibbons, Patrick J. Hrdlicka
Energetically activated double-stranded probes with interstrand arrangements of intercalator-functionalized nucleotides enable recognition of mixed-sequence DNA hairpins with excellent binding specificity.
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Facile access to functionalized indenes and fused quinolines by regioselective 5-enolexo-dig Michael addition and cyclization reactions

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Org. Biomol. Chem., 2017, 15,9319-9330
DOI: 10.1039/C7OB02498C, Paper
Tohasib Yusub Chaudhari, Sandeep K. Ginotra, Vibha Tandon
Herein we report a facile approach to synthesise multi-substituted indenes and cyclopenta[b]quinolines under mild conditions.
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Arginine modification of lycosin-I to improve inhibitory activity against cancer cells

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Org. Biomol. Chem., 2017, 15,9379-9388
DOI: 10.1039/C7OB02233F, Paper
Peng Zhang, Jing Ma, Yujie Yan, Bo Chen, Bobo Liu, Cui Jian, Baode Zhu, Songping Liang, Youlin Zeng, Zhonghua Liu
Herein, arginine modification rendered Lycosin-I with higher anticancer activity, penetrability, and dissemination ability against solid tumor cells due to the optimized physicochemical properties and high serum stability.
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Synthesis of carbazole-based BODIPY dimers showing red fluorescence in the solid state

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Org. Biomol. Chem., 2017, 15,9283-9287
DOI: 10.1039/C7OB02419C, Communication
Chihiro Maeda, Takumi Todaka, Tomomi Ueda, Tadashi Ema
Carbazole-based BODIPY dimers 2a-g were synthesized via direct arylation.
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In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease

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Org. Biomol. Chem., 2017, 15,9297-9304
DOI: 10.1039/C7OB02281F, Paper
Atsushi Kato, Izumi Nakagome, Shinpei Nakagawa, Kyoko Kinami, Isao Adachi, Sarah F. Jenkinson, Jerome Desire, Yves Bleriot, Robert J. Nash, George W. J. Fleet, Shuichi Hirono
DMDP amide restored Hex A activity in the G269S Tay-Sachs patient cells up to 43% of the wild type.
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Selective C-H Bond Electro-oxidation of Benzylic Acetates and Alcohols to Benzaldehydes
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02300F, Paper
(image) Open Access
Mateus R Barone, Alan Morenc Jones
A chemical oxidant-free and mediator-free, direct electro-oxidation of both benzylic alcohols and benzylic esters are reported. The scope of the reaction is explored as a function of both steric and...
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Structure-reactivity correlations of the abnormal Beckmann reaction of dihydrolevoglucosenone oxime
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02499A, Paper
Amani Alhifthi, Benjamin L Harris, Lars Goerigk, Jonathan White, Spencer J Williams
A structural, spectroscopic and computational study of a series of oximes was undertaken to investigate how geometric and structural changes relevant to the reaction coordinate for the Beckmann reaction (normal...
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Na2S mediated synthesis of terminal alkynes from gem-dibromoalkenes
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02431B, Communication
Radhey M Singh, Durgesh Nandini, Kishor Chandra Bharadwaj, Tanu Gupta, Raj Pal Singh
Na2S-mediated facile synthesis of terminal alkynes from gem- dibromoalkenes, at 20/40 ¬[degree]C under open flask conditions has been developed. Various precursors derived from heteroaromatic/aromatic/aliphatic aldehydes were found compatible. The reaction...
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Improved Synthesis of Symmetrically & Asymmetrically N-Substituted Pyridinophane Derivatives
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02508D, Paper
Andrew J. Wessel, Jason W. Schultz, Fenghzi Tang, Hui Duan, Liviu M. Mirica
The N,N'-di(toluenesulfonyl)-2,11-diaza[3,3](2,6)pyridinophane (TsN4) precursor was sought after as a starting point for the preparation of various symmetric and asymmetric pyridinophane-derived ligands. Various procedures to synthesize TsN4 had been published, but...
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Elemental sulfur mediated 2-substituted benzothiazole formation from 2-aminobenzenethiols and arylacetylenes or styrenes under metal-free condition
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02430D, Paper
Guo-Jun Deng, Guozheng Li, Jingjing Jiang, Feng Zhang, Fuhong Xiao
An oxidative cyclization of 2-aminothiophenols and arylacetylenes or styrenes for the synthesis of 2-alkyl benzothiazoles and 2-acylbenzothiazoles has been developed. Elemental sulfur was used as the effective oxidant to give...
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Specifically targeting mixed-type dimeric G-quadruplexes by berberine dimers
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02326J, Paper
Zi-Qi Li, Ting-Cong Liao, Cheng Dong, Jian-Wei Yang, Xiao-Jie Chen, Li-Hong Liu, Yuan Luo, Yuan-Yuan Liang, Wen-Hua Chen, Chun-qiong Zhou
Three polyether-tethered berberine dimers (1a-c) have been studied on their binding affinity, selectivity and thermal stabilization towards human telomeric dimeric quadruplex DNA (G2T1). Compound 1a with the shortest polyether linker...
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Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02654D, Paper
Scott Ryan Suter, Alexi A Ball-Jones, Madeline M. Mumbleau, Rachel Valenzuela, Jose M. Ibarra-Soza, Hassan Owens, Andrew Fisher, Peter A Beal
SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on...
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Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02567J, Communication
Lorenza Ghisu, Nicola Melis, Francesco Secci, Pierluigi Caboni, Massimiliano Arca, Regis Guillot, Thomas Boddaert, David J. Aitken, Angelo Frongia
2,2-Bis(pyridin-2-ylamino)cyclobutanols are prepared easily from 2-hydroxycyclobutanone and are transformed into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones via a periodinane-mediated ring expansion.
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25 years and still going strong: 2[prime or minute]-O-(pyren-1-yl)methylribonucleotides - versatile building blocks for applications in molecular biology, diagnostics and materials science

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02152F, Review Article
Patrick J. Hrdlicka, Saswata Karmakar
This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2[prime or minute]-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.
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Differentiation of enantiomeric anions by NMR spectroscopy with chiral bisurea receptors

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02318A, Paper
Suguru Ito, Manami Okuno, Masatoshi Asami
Enantiomeric 1H NMR signals of chiral anions are separated by forming 1 : 1 and 1 : 2 host-guest complexes with chiral bisurea.
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Metal-free oxidative para-acylation of unprotected anilines with N-heteroarylmethanes

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02490H, Paper
Min Liu, Xue Chen, Tieqiao Chen, Qing Xu, Shuang-Feng Yin
A selective oxidative para-acylation of unprotected anilines with methyl groups in N-heteroarylmethanes was achieved.
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Thermally induced N-S bond insertion reaction of diazo compounds with N-sulfenylsuccinimides: synthresis of sulfides and mechanism studies
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02488F, Paper
Xinfang Xu, Xiaolu Zhang, Yang Zheng, Lihua Qiu
A metal-free gem-functionalization reaction of diazo compounds with N-sulfenylsuccinimides via a formal N-S bond insert process has been reported. The transformation features mild reaction conditions, broad substrate scope and functional...
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Withapubesides A-D, natural inducible nitric oxide synthase (iNOS) inhibitors from Physalis pubescens
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02551C, Paper
Guiyang Xia, Tie Yao, Bing-Yang Zhang, Yang Li, Ning Kang, Shijie Cao, Liqin Ding, Lixia Chen, Feng Qiu
Four new steroid glycosides, withapubesides A-D (1-4) were isolated from the stems of Physalis pubescens L. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and...
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Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02406A, Paper
Jean-Denys Hamel, Tatsuru Hayashi, Melissa Cloutier, Paul R. Savoie, Olivier Thibeault, Meggan Beaudoin, Jean-Francois Paquin
A highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides is presented.
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Manipulating the stereoselectivity of the thermostable Baeyer-Villiger monooxygenase TmCHMO by directed evolution

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02692G, Paper
Guangyue Li, Maximilian J. L. J. Furst, Hamid Reza Mansouri, Anna K. Ressmann, Adriana Ilie, Florian Rudroff, Marko D. Mihovilovic, Marco W. Fraaije, Manfred T. Reetz
The thermostable Baeyer-Villiger monooxygenase TmCHMO and evolved mutants are viable catalysts in stereoselective reactions of structurally different ketones.
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Boronic acid recognition of non-interacting carbohydrates for biomedical applications: increasing fluorescence signals of minimally interacting aldoses and sucralose

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01893B, Paper
Angel Resendez, Md Abdul Halim, Jasmeet Singh, Dominic-Luc Webb, Bakthan Singaram
To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity.
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Switch-on Fluorescent/FRET Probes to Study Human Histidine Triad Nucleotide Binding Protein 1 (hHint1), a Novel Target for Opioid Tolerance and Neuropathic Pain
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02472J, Paper
Rachit Shah, Andrew Zhou, Carston R. Wagner
Histidine Triad Nucleotide Binding Protein 1 (Hint1) has emerged to be an important post-synaptic protein associated with a variety of central nervous system disorders such as pain, addiction, and schizophrenia....
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Copper-catalyzed ipso-selenation of aromatic carboxylic acids

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02066J, Paper
Jing Wang, Hongchen Li, Tao Leng, Miaochang Liu, Jinchang Ding, Xiaobo Huang, Huayue Wu, Wenxia Gao, Ge Wu
Study of the synthesis of diaryl and methyl aryl selenides in good to excellent yields, including mechanistic studies and demonstration of the utility of the products in the facile synthesis of 10H-phenoselenazine and 11-methyldibenzo-(b,f)-1,4-selenazepine.
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Cu-Catalyzed asymmetric Friedel-Crafts propargylic alkylation of phenol derivatives

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02133J, Paper
Long Shao, Xiang-Ping Hu
A copper-catalyzed asymmetric Friedel-Crafts propargylic alkylation of electron-rich phenol derivatives with a variety of propargylic esters has been described. With Cu(OTf)2 decorated with a chiral tridentate ketimine P,N,N-ligand as the catalyst, the reaction proceeded smoothly in high yields and with good to excellent enantioselectivities (up to 95% ee).
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Acid-Catalyzed Reaction of 2-Hydroxycyclobutanone with Benzylic Alcohols
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02545A, Paper
Francesco Secci, Regis Guillot, David J Aitken, Angelo Frongia, Massimiliano Arca, Giorgia Sarais, Alberto Luridiana, Alberto Martis
The acid-promoted syntheses of 2-(benzyloxy)cyclobutanones and bis(benzyloxy)dioxatricyclo decanes were achieved starting from 2-hydroxycyclobutanone and variously functionalized benzyl alcohols. The reaction sequences afforded the desired products in good to high yields...
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[small alpha]-Trifluoromethylated tertiary homoallylic amines: diastereoselective synthesis and conversion into [small beta]-aminoesters, [gamma]- and [small delta]-aminoalcohols, azetidines and pyrrolidines

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02506H, Paper
Fabienne Grellepois, Abdelkhalek Ben Jamaa, Nathalie Saraiva Rosa
The diastereoselective synthesis and the functionalization of homoallylic tertiary carbinamines containing a tetrasubstituted carbon stereocentre bearing a trifluoromethyl group are described.
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Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02454A, Paper
Elena Lenci, Alessio Rossi, Gloria Menchi, Andrea Trabocchi
A convenient synthesis of sp3-rich complex morpholines was achieved in two steps involving a Petasis three-component coupling reaction followed by an acid- or base-mediated cyclization.
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Regioselective phosphinylation of coumarins under green LED irradiation and its mechanism

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02478A, Communication
Qingrui Li, Xiuli Zhao, Yabo Li, Mengmeng Huang, Jung Keun Kim, Yangjie Wu
A regioselective and efficient approach to 3-phosphinylated coumarins was developed via the active P-centered radical generated by energy transfer and electron transfer processes under green LED irradiation.
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Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02043K, Paper
Morteza Shiri, Maryam Ranjbar, Zahra Yasaei, Fatemeh Zamanian, Behrouz Notash
A facile and domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed...
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Correction: Formation of [small beta]-(1,3-1,6)-D-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB90179H, Correction
(image) Open Access
Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kagoshima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki
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A Modular Approach Towards Functionalized Highly Stable Self-complementary Quadruple Hydrogen Bonded Systems
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02358H, Paper
Suresh Rayavarapu, Sanjeev Kheria, Dinesh R Shinde, Rajesh G. Gonnade, G. J. Sanjayan
Self-complementary quadruple hydrogen bonded systems have shown potential as key building blocks for developing various supramolecular polymers. Opportunities for introduction of multiple functionalities would further augment, in principle, their application...
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Pd-Catalyzed Regioselective Intramolecular Dehydrogenative C-5 Cross Coupling in an N-substituted Pyrrole-Azole System
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02676E, Paper
Ravi Prakash Singh, Krishna Nand Tripathi, Devalina Ray
Functionalized polycyclic pyrrole-azole structures possessing fused six membered and seven membered rings were directly synthesized via ligand-enabled Pd-catalyzed site selective intramolecular cross coupling of N-substituted pyrrole-azole. The C5-H activation in...
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Cooperative bimetallic catalysis in asymmetric allylic substitution

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02476B, Review Article
Jingke Fu, Xiaohong Huo, Bowen Li, Wanbin Zhang
Strategies using a chiral metal catalyst and the cooperative effect of a second achiral or chiral metal catalyst for asymmetric allylic substitution reactions are discussed.
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Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02377D, Communication
Adam Fessler, Corey Garmon, Thomas Heavey, Anthony Fowler, Craig Ogle
A new "clickable" bioconjugation platform based on isatoic anhydride.
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A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02579C, Paper
Jose. C. Gonzalez-Gomez, Nieves P. Ramirez, Teresa Lana-Villarreal, Pedro Bonete
The radical Smiles rearrangement of 2-aryloxybenzoic acids can be promoted by visible light at room temperature, in the presence of air and water, and free of noble metals.
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Control of porphyrin interactions via structural changes of a peptoid scaffold

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02398G, Paper
Woojin Yang, Boyeong Kang, Vincent A. Voelz, Jiwon Seo
A template to control porphyrin interactions is constructed by displaying porphyrins at defined positions on a helical peptoid.
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A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02028G, Paper
H. Mukherjee, J. Debreczeni, J. Breed, S. Tentarelli, B. Aquila, J. E. Dowling, A. Whitty, N. P. Grimster
Profiling the reactivity and stability of SVI-F warheads towards nucleophilic amino acids for the development of biochemical probe compounds.
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Synthesis, Computational, and Spectroscopic Analysis of Tunable Highly Fluorescent BN-1,2-Azaborine Derivatives Containing the N-BOH Moiety
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB02415K, Paper
Carl Jacky Saint-Louis, Renee N. Shavnore, Caleb D. C. McClinton, Julie A. Wilson, Lacey L. Magill, Breanna M. Brown, Robert W Lamb, Charles Edwin Webster, Alan K Schrock, Michael T Huggins
Nine new polycyclic aromatic BN-1,2-azaborine analogues containing the N-BOH moiety were synthesized using a convenient two-step, one-pot procedure. Characterization of the prepared compounds show the luminescence wavelength and the quantum...
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The diaza-Nazarov cyclization involving a 2,3-diaza-pentadienyl cation for the synthesis of polysubstituted pyrazoles

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB01949A, Paper
Balakrishna Aegurla, Rama Krishna Peddinti
Functionally-rich pyrazoles in a cascade reaction from in situ generated hydrazones and acetophenones under aerobic conditions were synthesized through novel enamine-imino diaza-Nazarov 4[small pi]-electrocyclization which is supported by DFT calculations.
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Cell-permeable bicyclic peptidyl inhibitors against T-cell protein tyrosine phosphatase from a combinatorial library

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02562A, Communication
Hui Liao, Dehua Pei
Cell-permeable, biologically active bicyclic peptidyl inhibitors against T-cell protein-tyrosine phosphatase were directly isolated from a combinatorial library.
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Regioselective synthesis of 2,3[prime or minute]-biindoles mediated by an NBS-induced homo-coupling of indoles

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02312J, Paper
Panpan Huang, Xiangjun Peng, Dan Hu, Huiwu Liao, Shaobin Tang, Liangxian Liu
An efficient method for the synthesis of 2,3[prime or minute]-biindole and [3,2-a]carbazole derivatives via an NBS-induced homo-coupling of indoles with high regioselectivity.
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Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02461D, Paper
Yaqi Yang, Zihang Ye, Xu Zhang, Yipeng Zhou, Xiantao Ma, Hongen Cao, Huan Li, Lei Yu, Qing Xu
Alcohols can be efficiently converted into thioethers by a transition metal- and base-free alkyl halide-catalyzed S-alkylation reaction with thiols or disulfides.
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A general method of Suzuki-Miyaura cross-coupling of 4- and 5-halo-1,2,3-triazoles in water

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02091K, Communication
Pavel S. Gribanov, Gleb A. Chesnokov, Maxim A. Topchiy, Andrey F. Asachenko, Mikhail S. Nechaev
A general method of the synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by Suzuki-Miyaura cross-coupling from 4- and 5-halo-1,2,3-triazoles.
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Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02411H, Communication
Yi Li, Xiaoji Cao, Yunyun Liu, Jie-Ping Wan
The enaminone modified three-component Povarov reactions enable the regioselective synthesis of 2,3-disubstituted quinolines.
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Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

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Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB02552A, Communication
Amit Kumar Yadav, Namit Dey, Sabyasachi Chattopadhyay, Munia Ganguli, Moneesha Fernandes
Carbamate- and amide-linked lysine-based generation-2 dendrimeric oligomers transport pDNA into cells very efficiently when complexed by incubation overnight.
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