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Toxic Alpha-synuclein Spreads Brain Cell Damage in Dementia
(image) Insights into how a key chemical disrupts brain cells in a common type of dementia have been revealed by scientists. Brain tissue from people with Dementia with Lewy Bodies (DLB) showed that the protein builds up in vital parts of neurons that connect cells and may jump from one cell to another through these connections. Scientists say the findings shed light on the causes of DLB and will help to accelerate the search for a treatment. The study, co-led by the University of Edinburgh, focused ...



First Ever Successful Intervention To Reduce Dementia Risk
(image) Computerized brain-training is now the first intervention of any kind to reduce the risk of dementia among older adults. The breakthrough results from a randomized controlled trial were just published in the journalIAlzheimer's (and) Dementia: Translational Research (and) Clinical Interventions. /I The article, "Speed of Processing Training Results in Lower Risk of Dementia", reports on the latest findings from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study funded by the National Institutes of Health....



Heart Attack Survivors are at Increased Risk of Vascular Dementia
(image) Heart attack was associated to increase the risk of vascular dementia by 35 percent. The risk was also found to be elevated after the heart attack for up to 35 years, reveals a new study. This is the somewhat disheartening result of a registry-based study from the Department of Clinical Epidemiology at Aarhus University, which has been published in the journal iCirculation./i The researcher behind the study is medical doctor and PhD Jens Sundbll. As part of his PhD dissertation, he has ...



Why Don't the Alzheimer Drugs Work on Patients?
(image) Semagacestat may not be true (and) #947;-secretase inhibitors as largely assumed, but alternatively, they may result in accumulation of toxic intraneuronal A (and) #946;, found a new study published in ICell Report /I journal. By reducing A (and) #946; production, (and) #947;-secretase inhibitors were considered able to treat Alzheimer's disease (A (and) #946; hypothesis). In fact, nearly 50 clinical trials have been conducted using potential (and) #947;-secretase inhibitors for Alzheimer's disease or several types of cancer....



Blood-thinning Drugs Can Reduce Dementia Risk in Atrial Fibrillation Patients
(image) Blood-thinning drugs that reduce the risk of stroke in patients with atrial fibrillation (AF) was found to reduce the risk of dementia as well, reveals a new study. Among 444,106 patients with atrial fibrillation (an abnormal heart rhythm), those who were taking anticoagulant drugs to prevent blood clots at the start of the study had a 29% lower risk of developing dementia than patients who were not on anticoagulant treatment. When the researchers looked at what happened during the period of ...



Here's How Seizures Lead to Memory Loss
(image) Seizures are associated with memory loss and other cognitive deficits in Alzheimer's patients. The mechanism as to how seizures lead to memory loss has been explained by the research team. In a study published in the journal iNature Medicine,/i a team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models. A better understanding of this new mechanism may lead to future strategies to reduce ...



Being Aware of Memory Loss Can Prevent Alzheimer's Disease
(image) Memory loss is an early symptom of Alzheimer's disease. An individual who is aware of their memory loss is less likely to develop dementia, whereas people who are not aware are more likely to develop Alzheimer's disease later, reveals a new study. A new study at the Centre for Addiction and Mental Health (CAMH) has found a clinically useful way to predict who won't develop Alzheimer's disease, based on patients' awareness of their memory problems. People who were unaware of their memory loss, ...



High Blood Pressure in 40s Can Increase Dementia Risk in Women
(image) bHighlights/b ul class="group-list punch-points" liWomen who develop high blood pressure in their mid-life or 40s were at an increased risk of developing dementia later in life/li liWomen who develop high blood pressure in their 30s were not at the risk of developing dementia/li liCompared to men, women were at higher risk of developing high blood pressure and dementia /li/ul Women who developed high blood pressure in their 40s were found to be at an increased risk ...



Economic Burden of Dementia in the United States
(image) While dementia is a common term and usually associated with the elderly population, frontotemporal degeneration, may be a new term to many of us. Frontotemporal degeneration (FTD) accounts for 20 to 50 percent of dementia cases. FTD is more common in individuals below the age of 65 and creates a havoc in an individual's quality of life by altering their language, personality, behavior, cognition and motor function. Research led by Florida Atlantic University, in collaboration with the Association ...



Smell Loss: Predictor for Dementia Risk
(image) bHighlights:/b ul class = "group-list punch-points"liSenior citizens who show diminishing sense of smell are more likely to have dementia./li liThe sense of smell is closely connected with brain function and health./li liLoss of the sense of smell is often an early sign of Parkinson's or Alzheimer's disease./li/ul Not being able to identify four out of five common odors are more than twice as likely as those with a normal sense of smell to develop dementia within five years, ...



New Ways may Help Build a Better Brain and Prevent Dementia
(image) Alzheimer's disease (AD) begins slowly. It first involves the parts of the brain that control thought, memory and language. People with AD may have trouble remembering things that happened recently or names of people they know. More than 5 million Americans today are affected by AD. If nothing is done to stop this upward trajectory, there will be more than 16 million people with AD in the United States and more than 60 million people with AD worldwide by 2050. In the past 25 years, only five ...



Chemotherapy may Increase Survival for Stage III Colon Cancer Patients with Dementia
(image) Chemotherapy may increase survival for advanced colon cancer in older patients with dementia, reveals a new study. The study is published in the journal iCancer Epidemiology, Biomarkers (and) Prevention/i, a journal of the American Association for Cancer Research. Yingjia Chen, PhD, a postdoctoral fellow in the Memory and Aging Center in the Department of Neurology at University of California, San Francisco. bStudy and The Results:/b Yingjia Chen, PhD and colleagues, a postdoctoral ...



Magnesium Levels in Blood Linked to Dementia Risk
(image) Dementia is a general term for a decline in mental ability severe enough to interfere with daily life. People with both high and low levels of magnesium in their blood may have a greater risk of developing dementia. This is according to a study published in the online issue of Neurology (Regd) , the medical journal of the American Academy of Neurology. "These results need to be confirmed with additional studies, but the results are intriguing," said study author Brenda C.T. Kieboom, MD, MSc, of Erasmus ...



Alzheimer's Disease, Dementia Linked To Unnoticed Gene
(image) ApoE4, the notorious genetic marker of Alzheimer's disease and other forms of dementia, might not be the sole risk factor, another gene, TOMM40, complicates the picture. Although ApoE4 plays a greater role in some types of aging-related memory ability, TOMM40 may pose an even greater risk for other types. TOMM40 and APOE genes are neighbors, adjacent to each other on chromosome 19, and they are sometimes used as proxies for one another in genetic studies. At times, scientific research has ...



People With Dementia are Usually Physically Aggressive
(image) Dementia is an overall term that describes a wide range of symptoms associated with a decline in memory or other thinking skills. Physical aggression among people with dementia is not unusual. Study from Lund University in Sweden showed that one-third of patients with the diagnosis Alzheimer's disease or frontotemporal dementia were physically aggressive towards healthcare staff, other patients, relatives, animals and complete strangers. This manifestation of disease must be both understood and addressed in the right way....



Age-related Memory Loss Can Be Reversed: Study
(image) Osteocalcin is a hormone produced by bone cells and by boosting blood levels of osteocalcin can aid in reversing age-related memory loss, reveals a new study. The research team also identified a receptor for osteocalcin in the brain, paving the way for a novel approach to treating age-related cognitive decline. The mouse studies were led by Columbia University Medical Center (CUMC) researchers. The paper was published in the online edition of the iJournal of Experimental Medicine./i "In ...



Women Who Carry Copies of APOE ?4 Allele Have a Greater Risk of Developing Alzheimer
(image) Apolipoprotein E ?4 allele is the main genetic risk factor for late-onset Alzheimer disease. Are female carriers of the apolipoprotein E ?4 allele at greater risk of developing the disease than men? A new article published by JAMA Neurology examines that question. Alzheimer's is a progressive disease. This means that gradually, over time, more parts of the brain are damaged. As this happens, more symptoms develop, they also become more severe. The prevalent view has been that women who carry ...



Artificial Intelligence may Accelerate Early Diagnosis of Dementia
(image) An algorithm developed using artificial intelligence techniques can recognize the signatures of dementia two years before its onset, using a single amyloid PET scan of the brain of patients at risk of developing Alzheimer's disease. The findings of the study are published in the journal iNeurobiology of Aging./i The algorithm was developed by scientists from the Douglas Mental Health University Institute's Translational Neuroimaging Laboratory at McGill. Dr. Pedro Rosa-Neto, co-lead author ...



Dementia Patients Spend Last Year Of Their Life In Accident (and) Emergency
(image) Accident and Emergency (A (and) E) attendance among people with dementia in their last year of life has become very common and is found to be increasing, reveals a new study. The paper was published in the journal iAlzheimer's (and) Dementia: The Journal of the Alzheimer's Association/i. In recent years, there has been a drop in the number of people with dementia dying in hospital, which has widely been seen as demonstrating better end of life care. However, the team of researchers from King's ...



Dementia Risk Linked To Fluctuations in Home-Monitored Blood Pressure Levels
(image) bHighlights/b ul class = "group-list punch-points" liThe American Heart Association recommends home monitoring for all the people with high blood pressure to help the healthcare provider determine whether treatment is working./li liHome monitoring of blood pressure may be more reliable than office measurements because of the "white-coat" effect./li liVariability in systolic blood pressure doubles the risk of Alzheimer's and increases risk of vascular dementia by three times./li/ul Fluctuation ...



New Way to Reverse Memory Loss in Alzheimer's Patients
(image) bHighlights:/b ul class="group-list punch-points"liAn enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes and causes memory loss /liliInhibiting the enzyme HDAC2 can reverse memory loss in Alzheimer's. HDAC2 inhibitors can also affect other members of HDAC/liliA new approach has been found to target HDAC2, by blocking its interaction with a binding partner called Sp3/li/ul In the brains ...



Cardiovascular Risk Factors During Midlife Increase Risk of Dementia
(image) bHighlights:/b ul class="group-list punch-points" liCardiovascular risk factors like diabetes and hypertension during midlife increase the risk of developing dementia, finds a new study /li liMidlife vascular health plays a role in increasing the risk of developing dementia later in life /li liAddressing risk factors early can reduce chances of developing dementia/li/ul Middle-aged adults with cardiovascular risk factors are at a higher risk of dementia, finds a large, ...



Is There a Link Between Dementia and Post-traumatic Stress Disorder?
(image) Post-traumatic stress disorder is is a brain disorder that can occur after experiencing a traumatic event. Various epidemiological studies have shown that individuals suffering from PTSD are more prone to acquiring Alzheimer's disease later in their lives. Researchers at the University Medical Center Goettingen, Germany, now shed light on the molecular mechanism that links the two disorders. PTSD frequently relive the traumatic event, often triggered by stimuli similar to those that accompanied the trauma....



Higher Dementia Risk Associated With Birth in High Stroke Mortality States
(image) A band of states in the southern United States is known as the Stroke Belt because living there has been associated with increased risk of a number of conditions, including high blood pressure, diabetes, stroke and cognitive impairment. Is being born in states with high stroke mortality associated with dementia risk in a group of individuals who eventually all lived outside those states? A new article published by JAMA Neurology reports the results of a study that examined that question in ...



Post Operative Delirium Increases Long Term Risk of Dementia
(image) Delirium is a mental disorder that accompanies a sudden change in behavior, with patients suffering acute confusion, inattention, disorganized thinking and fluctuating mental status. However, little previous research has focused on whether delirium itself portends or even accelerates a decline into dementia in patients who showed no previous signs of cognitive impairment. Patients over the age of 65 were assessed as cognitively normal prior to surgery. This study, led by Professor Juraj Sprung ...



Can Dementia Be Prevented?
(image) bHighlights/b ul class = "group-list punch-points" liOne in three dementia cases are preventable by managing lifestyle factors/li liNonpharmacologic interventions like social contact and exercise help prevent dementia/li liIncreasing education in early life can reduce the incidence of dementia by 20 percent/li/ul One-third of the world's dementia cases can be prevented by managing lifestyle factors such as hearing loss, smoking, hypertension and depression, reveals ...



Proton-pump Inhibitors Do Not Cause Dementia
(image) Several studies have reported associations between proton-pump inhibitor (PPI) use and dementia. New research published on July 18 in Gastroenterology, the official journal of the American Gastroenterological Association (AGA), puts these claims to rest. The study authors report that there is no convincing evidence to support the suggestion that PPI use increases dementia risk. These findings are based on an analysis of 13,864 participants from the Nurses' Health Study II who completed testing ...



Weekly Social Interaction can Improve Quality of Life Among Dementia Patients
(image) Dementia is a broad umbrella term used to describe a range of progressive neurological disorders. People with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. Memory loss is a common symptom of dementia. Person-centred activities combined with just one hour a week of social interaction can improve quality of life and reduce agitation for people with dementia living in care homes, while saving money, claims a recent study. The findings ...



Here's How the Antioxidant In Strawberries Retards Age-Related Memory Loss
(image) bHighlights/b ul class = "group-list punch-points" li A natural compound in strawberries reduces cognitive deficits and inflammation associated with aging in mice. /li li Antioxidant fisetin, could help treat age-related mental decline and conditions like Alzheimer's or stroke. /li li Fisetin has been tested in mouse models and should be tested in humans before use./li/ul Fisetin in strawberries might be helpful as a preventative for many age-associated neurodegenerative diseases according to studies tested in mice....



Daily Consumption Of Citrus Fruits Lowers Dementia Risk
(image) Older adults who consume orange and grapefruit daily can lower the risk of dementia by 23 percent, reveals a new study. Researchers from Tohuku University in Japan have found that daily intake of any citrus fruits such as oranges, grapefruits, lemons or limes can cut the chances of developing the incurable brain condition by almost a quarter. The findings suggested that the citric acid contains a chemical nobiletin, which in animal tests has shown to slow or reverse impairment of memory. ...



Dementia Risk Doubled in Men with Traumatic Brain Injury
(image) Head injuries like skull fractures, scalp wounds or concussion may increase the risk of developing dementia in men by releasing an overload of inflammatory particles into the brain, finds a study. Researchers from the University of Maryland in the US showed that the inflammation caused by traumatic brain injury can spread and cause long-lasting damage. The findings indicated that the risk is particularly high for men aged between 41 and 56. This could help guide treatment of the injuries, whose severity is often difficult to gauge....



Traumatic Brain Injury Increases Dementia Risk In Middle-age
(image) Traumatic brain injury (TBI) has been linked with an increased risk for dementia in working-age adults. But no link was found between TBI and later onset of Parkinson's disease or ALS in the entire Finnish population, reveals a new study. The researchers believe that these results may play a significant role for the rehabilitation and long-term monitoring of traumatic brain injury patients. Traumatic brain injuries (TBI) are among the top causes of death and disability, particularly among the young and middle aged....



By 2040 1.2 Million People in England and Wales Will be Living With Dementia
(image) Due to increased life expectancy by 2040, there will be over 1.2 million people living with dementia in England and Wales (an increase of 57% from 2016)say researchers in The BMJ today. Their results show that, although the incidence (number of newly diagnosed cases) of dementia is falling, the overall prevalence (number of people living with the condition) is set to increase substantially as people live longer and deaths from other causes, such as heart disease, continue to decline. With ...



Interactive Tools Help Provide Positive Stimulation to Dementia Patients
(image) Dementia is not a specific disease. It's an overall term that describes a wide range of symptoms associated with a decline in memory or other thinking skills severe enough to reduce a person's ability to perform everyday activities. Alzheimer's is the most common type of dementia, but not the only one. Many people living with dementia reside in long-term care facilities, where the lack of stimulation can result in behaviors such as hitting, screaming, and wandering. Common measures to avoid ...



Psychosis To Be Misdiagnosed For Dementia in Alzheimer's Patients
(image) Alzheimer's disease is a type of dementia characterized by protein deposits in the brain including twisted fibers found inside brain cells. Dementia with Lewy bodies is believed to be caused by the buildup of a different abnormal protein aggregate found in nerve cells in the brain. People with Alzheimer's disease who experience psychosis including delusions and hallucinations are five times more likely to be misdiagnosed with dementia with Lewy bodies compared to patients who do not, new research suggests....



New Technology Helps Dementia Patients Manage Their Responsive Behaviours
(image) Lack of stimulation in dementia patients can result in "responsive" behaviors like hitting, screaming, and wandering, specially in people who are in long-term care facilities. Common measures to avoid such "responsive" behaviors, such as antipsychotic medications and personalized recreational and music therapy programs, can cause adverse health effects in the former case and be difficult for staff to find time to carry out in the latter case. A team of human factors/ergonomics researchers ...



Lifespan of Dementia Patients Linked With Well-Being Of Caregivers
(image) Dementia patients can possibly die much earlier than expected, if their family caregivers are mentally stressed, reveals a new study. From 2007 until 2016, University of California (UC), Berkeley researchers tracked the mortality of 176 patients with neurodegenerative diseases that are corrosive to brain function. They also measured the mental health of the family members who took care of them. Their findings published in the Proceedings of the iNational Academy of Sciences,/i indicate ...



Preventing Cognitive Decline, Dementia By Examining Evidence On Interventions
(image) Additional research is needed to further understand and gain confidence in the effectiveness of cognitive training, blood pressure management for people with hypertension, and increased physical activity, as the evidences are inconclusive in preventing cognitive decline and dementia, reveals a recent study. "There is good cause for hope that in the next several years much more will be known about how to prevent cognitive decline and dementia, as more clinical trial results become available and more evidence emerges," said Alan I....



Memory Loss Treatment Through Genes
(image) Identifying the genes that are linked to memory can pave the way for treatment of conditions like Alzheimer's disease and epilepsy. The Peter O'Donnell Jr.Brain Institute conducted a study and the results of which is a new strategy to identify genes that underlie specific brain processes. This strategy may eventually help scientists develop treatments for patients with memory impairments.Many of these genes were not previously linked to memory, but now any number of labs could study them and understand their basic function in the brain....



Therapy for Parkinson's may prove effective for Alzheimer's and Huntington's Disease
(image) Neurodegenerative diseases are usually incurable, but an effective treatment for Parkinson's disease might also work for Alzheimer's and Huntington's diseases. Researchers have found that abnormal proteins found in these neurodegenerative diseases all share a similar ability to cause damage when they invade brain cells. The finding potentially could explain the mechanism by which Alzheimer's, Parkinson's, Huntington's and other neurodegenerative diseases spread within the brain and disrupt normal brain functions....



Omega-3 Rich Diet can Ward Off Alzheimer's Disease: Research
(image) Keeping Alzheimer's disease (AD) away may be as simple as adding food rich in omega-3 to your diet, claims a recent study. In the article published in the Journal of Alzheimer's Disease, researchers have found that for patients with high omega-3 levels, blood flow in specific areas of the brain is increased. "This study is a major advance in demonstrating the value of nutritional intervention for brain health by using the latest brain imaging," commented George Perry, Editor-in-Chief of the journal....



Exercise Regularly : Stay Away From Alzheimer's Disease
(image) Physical activity is associated with a reduced risk of Alzheimer's disease, says a panel of researchers and not-for-profit leaders, led by UBC's Okanagan campus. The researchers also confirmed that regular physical activity may improve the performance of daily activities for people afflicted with Alzheimer's. Their conclusions may have significant implications for the 1.1 million Canadians affected directly or indirectly by dementia. "As there is no current cure for Alzheimer's, there is an ...



Delayed Use of Blood Thinners for Patients With Atrial Fibrillation Increases Dementia Risk
(image) Dementia rates increase when anticoagulation treatment is delayed for patients with atrial fibrillation, the most common heart arrhythmia in the world that affects more than 2.7 million American adults. The first-of-its-kind, large-scale study, conducted by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City, included more than 76,000 atrial fibrillation patients with no prior history of dementia who were treated with an antiplatelet or warfarin, a medication used ...



Dementia Risk Increases Due to Delayed Use of Blood Thinners in Atrial Fibrillation Patients
(image) Atrial fibrillation is the most common heart arrhythmia in the world. Around 2.7 million American adults are found to be affected with the heart disease. When the use of blood thinners or anticoagulation therapy has been delayed, there would be an increase in the risk of dementia, finds new study. The first-of-its-kind, large-scale study, conducted by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City, included more than 76,000 atrial fibrillation patients with ...



Belly Fat In Middle Age May Indicate Risk Of Dementia In Old Age
(image) Obesity has the potential to raise an older adult's risk for having difficulty thinking and making decisions (also known as "cognitive decline" or dementia). It is a complex health concern. Body mass index (BMI) is a scale that measures a person's weight in relationship to their height. Research shows that bolder adults who have an elevated BMI are at lower risk for dementia than people with lower BMIs/b. However, BMI may not be the best measure for obesity's effect on dementia. For example, ...



Gene Alteration may Increase Memory Loss in Alzheimer's Patients
(image) An alteration in a gene may speed up the loss of memory and thinking skills in people who are already at the risk of Alzheimer's disease, suggests a study. According to researchers, people with Alzheimer's risk, who have the gene mutation called the BDNF Val66Met allele, or the Met allele may have a more rapid decline of memory and thinking skills. Further, people with the gene mutation, who also had more beta-amyloid -- a sticky protein that can build up into plaques found in the brains ...



Walking Helps Reverse Brain Connections in Mild Memory Loss Patients
(image) bHighlights/b ul class = "group-list punch-points" li Physical activity helps reestablish some protective neuronal connections, thereby preserving memory. /li li A 12-week walking intervention with older adults suffering from mild cognitive impairment reversed decline in certain brain regions. /li li Exercise may be particularly useful in those who have already experienced mild memory loss. /li/ul Walking is a simple exercise that helps in weight loss and also protects the heart....



Prevent Stroke to Reduce Dementia In the Elderly
(image) bHighlights/b ul class="group-list punch-points"liStroke occurs when the blood supply to the brain is blocked or when the blood vessel in the brain bursts./li liPrevention of Stroke strategy may reduce the risk of dementia in the elderly, finds new study./li/ul Stroke or brain attack may occur when the blood supply to the brain is cut off. Prevention of stroke may also reduce the risk of dementia in older people, finds a new study from the University of Western Ontario. Approxinately ...



'Memory Proteins' Cause Dementia in Alzheimer's Disease
(image) bHighlights/b ul class="group-list punch-points" liAccumulation of amyloid plaques is thought to be responsible for dementia associated with Alzheimer's disease, but autopsies and brain images have revealed that there can be high levels of amyloid without displaying symptoms of AD./li liLow levels of a protein NPTX2 disrupts the memory-related neural circuits in the brain thus resulting in memory-failure or dementia, according to new findings./li liThis protein is essential for ...



Daily Consumption of Sugary Beverages, Juices Increases Brain Damage, Dementia Risk
(image) People who consume sugary beverages like sodas and fruit juices are more frequently are more likely to suffer from poorer memory, have smaller brain and hippocampal volumes. Hippocampus is an area of the brain that is important for memory. Drinking sugary beverages on a daily basis increases the likelihood of stroke and dementia by three times. These findings appear separately in the journals Alzheimer's (and) Dementia and the journal Stroke. "Our findings indicate an association between higher ...