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Latest Alcoholic Liver Disease News



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Alcohol Alters Expression of Genes That Regulate Cholesterol
(image) Drinking alcohol may induce changes to a cholesterol-regulating gene. The findings of a recent study suggest that these changes to the gene, known as PCSK9, may explain at least some of the differences in how cholesterol is processed in people who drink alcohol. The research team caution that their analysis looked at and found only associations between alcohol consumption and epigenetic changes, not cause-and-effect, and that more studies are needed to demonstrate any direct link. "Small ...



Gene Therapy Aids in Treating Alcoholism
(image) A novel gene therapy discovered aids in treating alcoholism by using shRNA technology delivered, which reduces aldehyde dehydrogenase (ALDH2) expression, reveals a new study. Researchers used gene transfer to block the expression of one of the two main enzymes that break down alcohol in the liver, leading to the accumulation in liver cells of acetaldehyde, a metabolic byproduct of ethanol. The inability to metabolize acetaldehyde produces strong effects in people, such as dizziness and ...



Liver Cancer in Children Needs Better Modes Of Diagnosis
(image) Metabolic differences between hepatoblastoma subtypes, and several biomarkers that can help obtain more accurate subtyping of the disease has been identified. Hepatoblastoma is a rare pediatric liver cancer, usually diagnosed in the first three years of life. Histological methods are used to distinguish between the different subtypes of hepatoblastoma. There are many subtypes of hepatoblastoma, the two major ones being fetal and embryonal. Clinically, pure fetal cases have the best prognosis....



Brain's Immune System Linked to the Desire to Drink Alcohol
(image) The link between the brain's immunity and the motivation to drink alcohol at night has been identified by a research team at the University of Adelaide. The team was able to switch off the impulse to drink alcohol in mice by giving a drug that blocks a specific response from the immune system in the brain. The study published in the journal iBrain, Behavior and Immunity/i, this research is one of the first of its kind to show a link between the brain's immunity and the urge to drink alcohol at night....



Chronic Cell Death Promotes Liver Cancer
(image) Liver cancer occurs predominantly in patients whose liver has been damaged as a result of chronic disease. Until now it has remained in the dark how these events are linked at molecular level. An international team of scientists from the German Cancer Research Center and the University of Zurich has now shown that chronic cell death promotes the development of cancer. The more cells die, the more the remaining cells have to divide. In this process, they accumulate mutations: fertile ground for liver cancer to develop....



Alcohol Industry Misrepresenting the Link Between Alcohol and Cancer
(image) Not everyone who drinks alcohol will develop cancer. But on the whole, scientists have found that some cancers are more common in people who drink more alcohol than others. Recently scientists have claimed that in a bid to protect its profits, alcohol industry is misleading the public by downplaying and misrepresenting the link between alcohol and cancer - especially breast cancer. The researchers from the London School of Hygiene (and) Tropical Medicine with the Karolinska Institutet, Sweden ...



Alcohol During Pregnancy? A Strict No! - Fetal Alcohol Syndrome Awareness Day
(image) h2 class="all"Highlights:/h2ul class="group-list punch-points"liFetal alcohol syndrome refers to the various neurological and physical complications in the fetus associated with maternal alcohol intake./liliFetal alcohol syndrome is the most important cause of preventable mental handicap in children in the Western world./liliFetal alcohol syndrome day is observed on the 9supth/sup September annually aims to raise awareness about the dangers to the fetus ...



Does Alcohol Affect the Risk of Developing an Abdominal Aortic Aneurysm?
(image) In an analysis of published studies, lower levels of alcohol consumption were associated with a lower risk of abdominal aortic aneurysm until approximately 15 to 20 g/day, with an increasing risk thereafter. In the iBritish Journal of Surgery/i analysis, the increase in risk beyond 2 units/day was stronger in men than in women. An abdominal aortic aneurysm occurs when an area of the aorta--the main blood vessel that supplies blood to the abdomen, pelvis, and legs--becomes very large or balloons out....



Combining Substance Abuse Treatment With Regular Medical Care can Beat Opioid or Alcohol Addiction
(image) Alcohol abuse can harm your relationships, cause you to miss work, and lead to legal problems such as driving while drunk. When you abuse alcohol, you continue to drink even though you know your drinking is causing problems. Combining substance abuse treatment with regular medical care can successfully treat people with opioid or alcohol addiction. According to researchers, this model can be a lower-cost and more-accessible way to treat opioid addiction than expanding the nation's supply of specialty care clinics....



Binge Drinking in Early 20s can Alter Brain Functioning
(image) Binge drinking is the practice of consuming large quantities of alcohol in a single session, usually defined as five or more drinks at one time for a man, or four or more drinks at one time for a woman. Moderate drinking is fine, but beware, binge drinking in early 20's can alter your brain functioning, especially for men. According to researchers, brain functions in young men and women, aged 23 to 28, are changed by long-term alcohol use, but that these changes are significantly different in men and women....



Alcohol Consumption Alters Brain Functioning Differently in Young Men and Women
(image) Many people start to drink alcohol during adolescence and young adulthood. Long-term alcohol consumption may alter brain functioning differently in young men and women, reveals a new study. This indicates not only that young people might be at increased risk of long-term harm from alcohol use, but also that the risks are probably different in men and women, with men possibly more at risk. This work is presented at the ECNP meeting in Paris. A Finnish research group worked with 11 young men ...



Enzyme Produced in the Liver Can Treat Fatty Liver Disease
(image) Increased production of the enzyme DPP4 by the liver promotes an increase in body fat, the development of non-alcoholic fatty liver disease and insulin resistance, reveals a new study. "In combination with our observations from additional human and cell studies, these results indicate that increased DPP4 production by the liver is the cause rather than the consequence of a fatty liver and insulin resistance," says the head of the study, Annette Schurmann from the German Institute for Human ...



Early Detection of Liver Cancer Possible With Rapid Home Blood Test
(image) bHighlights/b: ul class="group-list punch-points"liLiver (hepatocellular) cancer is a leading cause of cancer-related deaths worldwide; in 2015 alone 788000 persons died due to liver cancer according to a World Health Organization (WHO) estimate/li/ul ul class="group-list"liEarly diagnosis and treatment remains a challenge as the disease does not become symptomatic until the advanced stages/li/ul ul class="group-list"liNew rapid and ...



Malnutrition and Alcoholism Linked to Rise in Tuberculosis in India
(image) A new study reveals a striking link between malnutrition, heavy alcohol use and tuberculosis (TB) in southern India. The findings, which appear in the journal iPLOS ONE/i, are part of an international collaboration between Boston University School of Medicine (BUSM), the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) in India and Rutgers University. Researchers from these institutions are collaborating on a large cohort study of TB cases, the Regional Prospective ...



Fetal Alcohol Spectrum Disorder Among Children Estimated
(image) Fetal Alcohol Spectrum Disorder (FASD) affects nearly eight out of every 1,000 children in the general population, globally, reveals a new study by the Centre for Addiction and Mental Health (CAMH). In addition, it is estimated that one out of 13 women who consumed any alcohol at any point or frequency during pregnancy delivered a child with FASD. The study, published in iJAMA Pediatrics,/i estimates the prevalence or the frequency that FASD occurs for children from birth to age 16 in 187 countries....



Liver Protein Could Be Used To Treat Alcohol Liver Disease
(image) Excessive intake of alcohol can damage the liver but a protective response has been discovered to help treat alcoholic liver disease. The team led by researchers at Beth Israel Deaconess Medical Center (BIDMC), in collaboration with colleagues at the University of Pennsylvania also found that the same protective response may be involved in aversion to alcohol and could therefore help in the treatment of alcoholism. The research involves a protein called fibroblast growth factor 21 (FGF21), ...



Nonalcoholic Fatty Liver Disease can Cause Damage to Other Organs
(image) Nonalcoholic fatty liver disease is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. Approximately every third adult in the industrialized countries has a morbidly fatty liver. This not only increases the risk of chronic liver diseases (liver cirrhosis and liver cancer), but also in particular type 2 diabetes and cardiovascular diseases. The cause for this is the altered secretion behavior of the fatty liver. It increasingly produces glucose, ...



Traumatic Brain Injury in Kids Might Increase Risk of Alcohol Abuse Later in Life
(image) Alcohol use and traumatic brain injury (TBI) are closely related. Some people with TBI continue to drink heavily, which increases their risk of having negative outcomes. Researchers at Ohio State University have surveyed previous studies to investigate the relationship between traumatic brain injuries and alcohol abuse. They found evidence that traumatic brain injuries in children and adolescents could be a risk-factor for alcohol abuse in later life. When we think of the link between alcohol ...



Liver Cancer Incidences Seem to be on the Rise
(image) Primary liver cancer is a condition that happens when normal cells in the liver become abnormal in appearance and behavior. The cancer cells can then become destructive to adjacent normal tissues, and can spread both to other areas of the liver and to organs outside the liver. A little-studied gene may explain how some liver cancer cells obtain the nutrition they need to proliferate, according to new research from the University of Maryland. The results of this research will be published as an Editors' Pick in the Aug....



Braden Scale May Help Predict Poor Outcomes After Liver Transplantation
(image) Braden scale, an assessment which is performed for all hospitalized patients as per Medicare and Medicaid requirements can predict the surgery outcomes of a liver transplant patient. A multicenter study, led by principal investigator Vinay Sundaram, MD Cedars-Sinai uncovered an important new use for the Braden Scale. The findings could help doctors identify which patients should receive physical therapy or other targeted interventions to improve their recovery. bThe Braden Scale aims to ...



New Type of Liver Cancer Identified: Study
(image) Pediatric malignant liver disease, is a rare cancer. Scientists have better defined the disease and have taken a necessary step in achieving an optimum treatment, reveals a new study conducted at Children's Hospital Los Angeles. The research into hepatocellular malignant neoplasm-NOS (HEMNOS) is the largest case study of its kind to date. HEMNOS is a recently described entity that has features of the most common pediatric liver cancer hepatoblastoma (HB), and hepatocellular carcinoma (HCC) a liver cancer more commonly seen in adults....



Use of Alcohol High Among Women, Older Adults and Other Groups
(image) Alcohol use is on the rise among the U.S. population. High-risk drinking and alcohol use disorders were found to be on the rise in all sociodemographic groups, especially in women, elderly, racial or ethnic minorities and in individuals who have lower educational levels and family income, reveals a new study published by iJAMA Psychiatry./i Regular and detailed monitoring of trends in drinking and alcohol use disorders is important for the health of the nation. Monitoring alcohol consumption ...



Moderate Drinking May Improve Cognitive Health in Older Adults
(image) Older individuals who consume alcohol moderately on regular basis are more likely to live longer without dementia or other cognitive impairments than nondrinkers, according to a study led by University of California San Diego School of Medicine. The findings are published in the iJournal of Alzheimer's Disease./i Previous studies have found a correlation between moderate alcohol intake and longevity. "This study is unique because we considered men and women's cognitive health at late age ...



Undocumented Immigrants are Not Increasing Drug, Alcohol Crimes
(image) There are three major ways that alcohol and drugs can affect immigration status: substance abuse, criminal convictions, and criminal association. Not only can drugs and alcohol prevent you from getting a green card, but they can make you deportable. Despite being saddled with many factors associated with drug and alcohol problems, undocumented immigrants are not increasing the prevalence of drug and alcohol crimes and deaths in the United States, according to a new study published in the American Journal of Public Health....



Rates of Binge Drinking Drop Among College Students
(image) In adults, who are in the age group of 18 to 24, the rates of binge drinking, alcohol-impaired driving, and alcohol-related mortality have been diminishing among college students. However, in young adults of the same age who are not in college, the same numbers were found to be on the rise, reveals a new study. The study was published in the iJournal of Studies on Alcohol and Drugs./i The same study found that alcohol-related overdose hospitalizations and overdose deaths have increased among 18- to 24-year-olds as a whole....



Do You Think Consuming Alcohol Cures Stress?
(image) Do you crave a cocktail after a stressful event? Excessive alcohol consumption can elevate anxiety and dysregulate normal response to stressor. Drinking alcohol results in an alcohol use disorder (AUD) when consumption becomes excessive and dependence develops. Both stress and anxiety can contribute to the development of an AUD. Chronic stress can increase drinking, and chronic drinking can elevate anxiety and dysregulate normal responses to stressors. Behavioural flexibility and adaptive ...



Patients at Risk of Developing Alcoholic Liver Disease Identified
(image) Alcohol misuse is one of the three leading causes of preventable death from non-communicable diseases worldwide. Alcoholic liver disease (ALD) is one of the main causes of alcohol-related deaths and disability. In fact, ALD is the most common cause of death from liver cirrhosis and is estimated to be responsible for nearly half a million deaths and the loss of over 14 million disability-adjusted life years per year globally. Europe is the heaviest drinking region in the world in terms of the ...



Mystery Behind The Risk Of Liver Disease in Men With Hepatitis B
(image) bHighlights/b ul class = "group-list punch-points" li Men with Hepatitis B are more likely to be affected with severe liver disease than women but the reason remains unclear. /li li Men who are current drinkers had eight times the risk of developing liver disease and women who currently drink were four times as likely. /li li Even when accounting for smoking and alcohol, sex was still a strong, independent indicator of liver disease risk in the hepatitis B patients. /li/ul Liver ...



Drinking Alcohol Helps Recollect Earlier Learning
(image) People adopt various techniques to remember what they have learned. An interesting research finding shows that alcohol helps recall information that was learned before the drinking episode. In the University of Exeter study, 88 social drinkers were given a word-learning task. Participants were then split in two groups at random and told either to drink as much as they liked (the average was four units) or not to drink at all. The next day, they all did the same task again and those who had ...



Tips For Parents To Prevent Teen Drinking
(image) The habit of alcohol use begins in adolescence and though fewer Australian teenagers are drinking alcohol more needs to be done to curb the drinking habits. More than 2800 Australian students aged 12-17 took part in a survey of drinking behaviour, conducted by researchers from the University of Adelaide's School of Psychology and the Population Health group at the South Australian Health and Medical Research Institute (SAHMRI). "Harmful alcohol use is a serious problem in Australia, and drinking ...



Does Heavy Drinking Damage The Brain Of A Teenager?
(image) Heavy drinking in adolescents affects their ability to learn and impacts their overall health, as it is associated to the changes that occur in the activities of the brain, which may increase the risk of alcohol use disorder later in life, reveals a news study. Drinking alcohol, is a well-engrained and long-standing social habit in many countries around the world, even though the fact that alcohol has an impact on one's health is largely established, especially when it comes to heavy drinking....



New Guidelines Recommend Cirrhosis Screening in High Risk Patients
(image) Liver disease could become the commonest cause of death in working age people within the next year, as it develops without signs or symptoms. Recent guidelines recommend high risk patients to screen for cirrhosis, reveals a recent study. The study was conducted by liver specialists Mark Hudson at Freeman Hospital, Newcastle upon Tyne, and Nick Sheron at Southampton General Hospital. They say liver disease will probably overtake heart disease to become the commonest cause of death and options ...



Avoid Alcohol During Pregnancy: It Even Affects Your Grandchildren
(image) bHighlights/b ul class = "group-list punch-points" li Prenatal ethanol exposure (PrEE) from maternal consumption of alcohol, was thought to solely impact the directly exposed offspring. /li li But ethanol exposure generates neurobiological and behavioral effects in subsequent generations also. /li li Mice which were not directly exposed to alcohol had the same effects of those which were directly exposed. /li/ul One of the most important change that a soon-to-be mother ...



Victims Of Military Sexual Trauma Are At Increased Alcoholism Risk
(image) Military sexual trauma (MST) was found to be prevalent among military men and that it can also predict alcohol problems years later, reveals a recent study. MST is defined as sexual harassment and/or sexual trauma experienced during the course of military service. It includes uninvited or unwanted verbal or physical contact of a sexual nature, such as attention, verbal remarks, touching, sexual coercion, sexual assault, and rape. It happens to both men and women, and can have not only mental ...



Fetal Alcohol Exposure Increases Addiction Risk Later in Life
(image) No amount of alcohol is safe for pregnant women to drink. Data suggest that 20 to 30 percent of women do drink at some time during pregnancy. One of the many negative consequences when foetuses are exposed to alcohol in the womb is an increased risk for drug addiction later in life. Neuroscientists are discovering why. Researcher Roh-Yu Shen from the University at Buffalo Research Institute on Addictions is studying how prenatal alcohol exposure alters the reward system in the brain and how this change continues through adulthood....



Just One Drink Of Alcohol Everyday Puts You At Risk Of Colon Cancer
(image) If you are used to enjoying one or two drinks of alcohol everyday, you might want to rethink about it. Why? A new study done in the European Union (EU) found that citizens across the EU are consuming an average of 2 alcoholic drinks per day, placing drinkers at a 21% increased risk of developing colorectal cancer, in addition to other digestive cancers. The report, launched by United European Gastroenterology, revealed that the average daily intake of alcoholic drinks was 'moderate' (between ...



Bile Ducts Grown in Lab Could Help Treat Liver Disease
(image) The liver is a vital organ, meaning that one cannot live without it. A liver transplant is an operation that replaces a patient's diseased liver with a whole or partial healthy liver from another person. The liver has a remarkable ability to repair itself in response to injury. Cambridge scientists have developed a new method for growing and transplanting artificial bile ducts that could in future be used to help treat liver disease in children, reducing the need for liver transplantation. ...



Fresh Lease of Life for Liver Cancer Patients With New Drug Delivery System
(image) bHighlights:/b ul class="group-list punch-points"liAn anticancer drug, currently called BA-TPQ, appears to be effective against liver cancer cells/liliHowever, it is very poorly absorbed and tends to concentrate in other organs, as noted in animal studies, thereby causing toxicity/liliA drug delivery system in the form of minute cubes could help to circumvent these problems/li/ul bA specially-designed drug delivery system can help to transport a drug for hepatocellular ...



Trends in Palliative Care in Patients With End-stage Liver Disease
(image) Patients with end-stage liver disease in the US have low rates of referral for palliative care. although rates have been slowly increasing over time. The Hepatology study also found that certain socioeconomic and ethnic barriers may hinder access to palliative care services. Individuals with end-stage liver disease, an illness that can develop after the progression of chronic liver disease to advanced liver fibrosis and cirrhosis, often experience numerous symptoms. Historically, only a limited ...



Does Alcohol Make You Age Faster?
(image) The more alcohol you drink, the more the cells appear to age, reveals a recent study. Researchers pose a concern to rethink before you reach for that glass of whiskey. In the study that will be shared at the 40th annual scientific meeting of the Research Society on Alcoholism (RSA) in Denver June 24-28, researchers found that alcoholic patients had shortened telomere lengths, placing them at greater risk for age-related illnesses, such as cardiovascular disease, diabetes, cancer and dementia....



Alcohol can Result in Cognitive Impairments
(image) One's frequency of alcohol or drug use can determine the impairments in processing and using information that help with decision-making and planning simple tasks such as grocery shopping. Researchers at Columbia University's Mailman School of Public Health and Columbia University Medical Center found that cognitive impairments are not a problem limited to addiction patients in treatment, but constitute a broader problem among substance users in the U.S. general population. Results are published online in the journal Addiction....



Binge Drinking More Common in College Students With Disabilities
(image) College students with disabilities binge drink more often than their non-disabled student peers, according to a study. The study, providing the first picture of alcohol use and binge drinking by US college students with disabilities, is out in Public Health Reports, a SAGE Publishing journal and the official journal of the Office of the U.S. Surgeon General and the U.S. Public Health Service. "Substance abuse is the topic of high public interest, yet little attention is given to the experiences ...



Finding It Hard to Multi-Task? Increased Alcohol Use Could be a Reason
(image) Alcohol often has a strong effect on people - and throughout history, its a struggle to understand and manage alcohol's power. Impairments in processing and using information that help with decision-making and planning simple tasks such as grocery shopping are linked with one's frequency of alcohol or drug use according to a new study. Researchers at Columbia University's Mailman School of Public Health and Columbia University Medical Center found that cognitive impairments are not a problem ...



Patients With Fatty Liver Disease and Cirrhosis at Increased Risk of Liver Fibrosis
(image) Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Many conditions can damage the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Non-alcoholic fatty liver disease (NAFLD) is a common disorder characterized by abnormal accumulation of fat in the liver. NAFLD is diagnosed in up to one in three adults and one ...



Alcoholic Drinks can Contribute to Weight Gain
(image) With a pint of lager containing the same amount of calories as a slice of pizza, the calories in alcohol soon add up. Alcoholic drinks are high in calories particularly common beverages such as beer and cocktails. You might be surprised to find out how many calories there are in wine and how spirits like gin could be contributing to weight gain. Alcoholic beverage producers and retailers in the UK are failing to provide consumers with information on the calorie content of alcoholic drinks. ...



Starch and MUFA Increases Risk of Liver Injury, Fatty Liver Disease
(image) Carbohydrates, protein and fat and their metabolism have an impact on the development of obesity. As known, obesity is the root cause of various metabolic diseases including non-alcoholic fatty liver disease (NAFLD). Researchers from the University of California, San Francisco (UCSF), studied two groups of mice fed diets supplemented with either saturated fat or unsaturated fat. Surprisingly, they found that bingestion of starch and the monounsaturated fatty acid oleate led to fatty liver disease, ...



Women Residing in Rural Areas Report Higher Rates of Alcohol Misuse
(image) Alcohol can be an addictive substance. Not everyone who consumes alcohol will become addicted. However, certain people may be more susceptible to addiction. Compared with women living in urban areas, women who reside in these rural areas face multiple health concerns, including substance abuse issues, and often at greater rates. While the opioid epidemic in rural areas has gained attention, the rampant alcohol use has not. Appalachia - stretching from the southern tier of New York state ...



Use of Marijuana With Alcohol by Drivers May Turn Fatal
(image) Not everyone responds to alcohol and marijuana the same way, also smoking weed affects the absorption of alcohol. A latest study claims that use of marijuana in combination with alcohol by drivers, is especially dangerous. Drivers, who use both of them, are five times more likely to be responsible for causing fatal two-vehicle crashes than sober drivers involved in the same crashes. According to researchers from Columbia University, when the two were used in isolation, alcohol and marijuana ...



Breastfeeding For Less Than 6 Months Increases Risk of Fatty Liver Disease
(image) bHighlights/b ul class = "group-list punch-points" li Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder occurring due to fat accumulation in the liver. /li li Introducing infant formula milk before completing six months of breastfeeding increased likelihood of NAFLD by 40% during adolescence. /li li Adolescent children of women who were obese at the start of pregnancy were twice as likely to have NAFLD. /li Apart from obesity, there are few other ...



Risk for Binge Drinking Differs by Race, Income, Age
(image) Binge drinking can affect your mood and your memory and, in the longer term, can lead to serious mental health problems. Differing risks for binge drinking are based on race, income and age, finds a new study led by Indiana University-Purdue University Indianapolis assistant professor of psychology Tamika Zapolski. Zapolski found that African-Americans and Hispanics in the lowest income bracket (annual incomes less than (Dollor) 20,000) have a lower risk of binge drinking during adolescence compared ...