2017-04-11The PCSK9 inhibitor evolocumab has been shown to reduce LDL-cholesterol levels, but whether this reduction translates into a decline in cardiovascular events was previously unknown. Now, findings from the FOURIER trial — presented at the ACC.17 Scientific Sessions and published in The New England Journal
2017-03-31In patients with atrial fibrillation (AF) undergoing catheter ablation, uninterrupted anticoagulation with dabigatran, an oral, non-vitamin K antagonist, reduces the number of major bleeding events compared with uninterrupted anticoagulation with the vitamin K antagonist warfarin. This finding was presented at ACC.17 and simultaneously published in
2017-04-11A dual-pathway antithrombotic treatment strategy combining low-dose rivaroxaban with a P2Y12-receptor inhibitor has a similar risk of bleeding as the conventional dual antiplatelet therapy (DAPT; aspirin plus P2Y12-receptor inhibitor) approach for the treatment of patients with acute coronary syndrome (ACS). These
2017-03-31Two single injections of inclisiran, a small interfering RNA (siRNA) that targets PCSK9 mRNA, induce a 50% reduction in LDL-cholesterol (LDL-C) levels in 6 months, according to findings from the phase II ORION-1 trial presented at ACC.17. A total of 501 patients at high
2017-03-31A post-hoc analysis of the PARADIGM-HF trial in a subgroup of patients with heart failure with reduced ejection fraction (HFrEF) and with known diabetes mellitus or an HbA1c level ≥6.5% at screening shows that long-term reduction in HbA1c level is greater with sacubitril/valsartan (a
2017-03-31Results from a cross-sectional cohort study presented at ACC.17 show that Bolivian Tsimane have the lowest prevalence of coronary artery disease (CAD) of any population yet studied, with only 3% of the studied individuals having significant atherosclerotic disease, despite having a high infectious inflammatory burden.
2017-04-11Measurement of the instantaneous wave-free ratio (iFR) is noninferior to measurement of the fractional flow reserve (FFR) for assessment of coronary artery stenosis to guide percutaneous coronary intervention. This finding was simultaneously reported by the DEFINE-FLAIR and iFR-SWEDEHEART studies, both presented at the ACC.17 Scientific
2017-03-31In patients with venous thromboembolism who have completed 6–12 months of anticoagulation therapy and are in equipoise for continued anticoagulation, rivaroxaban treatment was associated with lower risk of recurrence compared with aspirin. These findings were presented at the ACC.17 Scientific Sessions by the EINSTEIN CHOICE
2017-04-11In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease, complete revascularization of both infarct-related and non-infarct-related coronary arteries reduces the risk of adverse cardiovascular outcomes compared with revascularization of the infarct-related (culprit) artery only. These findings come from a prospective, multicentre, randomized trial
2017-04-11Transcatheter aortic valve implantation (TAVI) with a self-expanding prosthesis is noninferior to surgery in patients with severe aortic stenosis and who are at intermediate surgical risk. This finding, from the randomized SURTAVI trial, was presented at the ACC.17 Scientific Sessions and published in NEJM.
2017-03-31Tolvaptan, a vasopressin 2-receptor antagonist that induces loss of free water, has been proposed as a good candidate for adjunct therapy to improve congestion and symptoms in patients with acute heart failure. Two clinical trials now show that tolvaptan as an adjunct to loop diuretics,
2017-04-11Prophylactic use of levosimendan does not reduce the rate of death, renal replacement therapy, perioperative myocardial infarction, or use of a mechanical cardiac assist device in patients undergoing cardiac surgery, according to findings from the LEVO-CTS trial presented at ACC.17. “Despite neutral results on these
2017-04-11Aortic valve replacement (AVR) is the only effective treatment for aortic stenosis. A new study presented at ACC.17 and published in The Lancet shows that subclinical leaflet thrombosis is common following AVR, but more so after transcathether AVR (TAVR) than surgical AVR (SAVR). Anticoagulation
2017-03-31The ESC has updated its 2006 consensus statement on clinical investigation of autologous adult stem cells for the treatment of acute myocardial infarction and heart failure. This initiative by a group of leaders in the field stimulates much-needed reflection and provides guidance to make cell therapy a clinical reality. Here, we offer our own perspective.
2017-02-02Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. Extracellular vesicles include apoptotic bodies, exosomes, and microvesicles (also known previously as microparticles). Originating from different subcellular compartments, the role of extracellular vesicles as regulators
2017-02-23From a global perspective, the large and diverse African population is disproportionately affected by cardiovascular disease (CVD). The historical balance between communicable and noncommunicable pathways to CVD in different African regions is dependent on external factors over the life course and at a societal level.
2017-02-09The optimal duration and type of antiplatelet therapy after implantation of a drug-eluting stent (DES) remains uncertain. At the time of the first-in-man implantation of the sirolimus DES in 1999, the protocol-defined dual antiplatelet therapy (DAPT) duration was only 2 months. Subsequently, DAPT duration was
2017-01-27Atherosclerosis is a chronic inflammatory disorder that develops in response to hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the development of atherosclerotic lesions. The role of natural killer T (NKT) cells in response to microbial pathogens and inflammatory disorders such
2017-03-16Nature Reviews Cardiology14, 133–144 (2017)In the version of this article initially published online and in print, there were some inaccuracies in Table 1. These errors have been corrected for the HTML and PDF versions of the article.