Subscribe: Nature Reviews Cardiology - Issue - science feeds
Preview: Nature Reviews Cardiology - Issue - science feeds

Nature Reviews Cardiology - Issue - science feeds

Nature Reviews Cardiology provides physicians and academics with authoritative and topical discussions of key developments in the field.


Stem cells: A step closer to cardiac repair therapies


Cardiomyocytes derived from induced pluripotent stem cells (iPSCs) show great promise for regenerating the damaged heart. The injection of cardiomyocytes differentiated from patient-specific iPSCs (autologous transplantation) would be an ideal strategy to avoid inducing an immune response. However, this approach faces important manufacturing challenges. An

Dyslipidaemia: Early-phase trials of lipoprotein(a) lowering


In phase I–II clinical trials, antisense oligonucleotides targeting apolipoprotein(a) mRNA have produced large reductions in the level of lipoprotein(a) — a major risk factor for cardiovascular disease and calcific aortic valve stenosis. Lipoprotein(a) is a modified LDL particle composed of LDL and apolipoprotein(a). No approved

Aortic diseases: Following up on endovascular aneurysm repair


Abdominal aortic aneurysm (AAA) is a very common cause of sudden death if left untreated. AAA is a swelling or gradual dilatation of the main artery of the body, the aorta, which can rupture once it becomes too swollen. This outcome can be prevented by

Diabetes: Cardiovascular benefits of semaglutide


Semaglutide, a glucagon-like peptide 1 analogue, reduces the rate of cardiovascular events in patients with type 2 diabetes mellitus who are at high cardiovascular risk. These findings from the SUSTAIN-6 trial were published in The New England Journal of Medicine.Of the 3,297 patients

Coronary artery disease: New polygenic risk score improves prediction of CHD


A risk score comprising >49,000 single-nucleotide polymorphisms (SNPs) improves prediction of the risk of coronary heart disease (CHD) relative to traditional clinical risk scores, according to an international study involving Professors Nilesh J. Samani, Veikko Salomaa, Samuli Ripatti, and Michael Inouye. “More than half of

Diabetes: Lipidomics refines CVD risk prediction


The addition of a small set of plasma lipid species to traditional risk factors improves the prediction of cardiovascular disease (CVD) outcomes in patients with type 2 diabetes mellitus (T2DM). This finding comes from a lipidomic analysis of plasma samples from 3,779 patients who participated

Pharmacotherapy: Current role of β-blockers after MI in patients without HF


When administered in the setting of an acute myocardial infarction, β-blockers decrease myocardial ischaemia, reduce the rates of reinfarction and serious ventricular tachyarrhythmias, and have substantial early benefits. However, the benefits of prolonged β-blockade after acute myocardial infarction are unproven and are discussed.

Applications of 3D printing in cardiovascular diseases


3D-printed models fabricated from CT, MRI, or echocardiography data provide the advantage of haptic feedback, direct manipulation, and enhanced understanding of cardiovascular anatomy and underlying pathologies. Reported applications of cardiovascular 3D printing span from diagnostic assistance and optimization of management algorithms in complex cardiovascular diseases,

Bioresorbable vascular scaffolds — basic concepts and clinical outcome


The introduction of percutaneous treatment of coronary artery stenosis with balloon angioplasty was the first revolution in interventional cardiology; the advent of metallic coronary stents (bare and drug-eluting) marked the second and third revolutions. However, the latest generation of drug-eluting stents is limited by several

Cardiovascular effects of bariatric surgery


Obesity is a major global health problem, and its multisystem effects are inextricably linked with elevated cardiovascular risk and adverse outcomes. The cardiovascular benefits of reversing obesity in adults are well-established. Compared with other weight-loss strategies, programmes that incorporate bariatric surgery for weight loss are

Pathogenesis and management of Brugada syndrome


Brugada syndrome is an inherited disease characterized by an increased risk of sudden cardiac death owing to ventricular arrhythmias in the absence of structural heart disease. Since the first description of the syndrome >20 years ago, considerable advances have been made in our understanding of