2017-03-02Autophagy is shown to restrict metabolic activation of adult haematopoietic stem cells, thereby contributing to the maintenance of their quiescence and stem cell potential throughout life.
2017-03-07Co-culturing embryonic stem cells and trophoblast stem cells in a 3D scaffold recreates early steps of mouse embryogenesis.
2017-03-01The specific binding of the lincRNA LINK-A tothe phospholipid PIP3 and the kinase AKT activates AKT and promotes tumorigenesis and resistance to AKT inhibitors.
2017-03-21DNA methylation by DNMT3B within the bodies of genes prevents aberrant transcription initiation.
2017-03-21Notch signalling is a conserved pathway that regulates cell fate decisions and is initiated by binding of a transmembrane ligand (Jagged (JAG) or Delta-like (DLL)) to a Notch receptor. This binding is followed by proteolytic cleavage of the receptor, which requires molecular tension. Building on
2017-03-21Centromeres are chromosomal sites for kinetochore assembly, which supports the attachment of spindle microtubules and chromosome segregation. The centromere is specified by the incorporation of the histone H3 variant CENP-A into nucleosomes. CENP-A interacts with components of the constitutive centromere-associated network (CCAN), which forms the
2017-03-21PRKR-like endoplasmic reticulum kinase (PERK) is an ER protein that regulates the unfolded protein response, but it has also been implicated in other cellular processes, including calcium (Ca2+) signalling. van Vliet et al. identified actin regulators as important PERK interactors in mammalian
2017-03-01Li and Lodish describe how a shift in our understanding of the molecular basis of sickle cell anaemia has led to clinical success.
2017-03-21Sirtuin 2 deacetylates the amino terminus of α-synuclein, thereby favouring its aggregation and toxicity associated with neurodegenerative diseases.
2017-02-15RNA is involved in the regulation of multiple cellular processes, often by forming sequence-specific base pairs with cellular RNA or DNA targets that must be identified among the large number of nucleic acids in a cell. Several RNA-based regulatory systems in eukaryotes, bacteria and archaea,
2017-01-25As a compartment border, the nuclear envelope (NE) needs to serve as both a protective membrane shell for the genome and a versatile communication interface between the nucleus and the cytoplasm. Despite its important structural role in sheltering the genome, the NE is a dynamic
2017-01-05Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby
2017-03-01The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II (Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the transcription process, the CTD is dynamically modified by post-translational modifications, many of which facilitate or hinder the recruitment of