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Preview: Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds





 



Genome Organization: Zooming in on nuclear organization

2017-03-22

Two studies report new methods for studying the 3D genome — one captures three-way contacts and the other calculates 3D structures of genomes in single cells.



Epigenetics: Cytosolic EZH1 muscles PRC2 out of the nucleus

2017-04-05

In mouse muscle cells, an isoform of EZH1 — a subunit of Polycomb repressive complex 2 (PRC2) — sequesters another subunit in the cytosol, thereby inhibiting PRC2 function.



Stress Responses: Membrane-to-nucleus signals modulate plant cold tolerance

2017-04-05

Cold stress activates Arabidopsis thaliana plasma membrane-localized CRPK1, which leads to 14-3-3 proteins entering the nucleus and promoting the degradation of CBF transcription factors, thus attenuating the cold-induced response.



Cell Senescence: A new role for ATM

2017-04-05

Cell senescence is associated with permanent withdrawal from the cell cycle in response to various stresses and ageing. Kang et al. screened human fibroblasts for factors that alleviate senescence and identified the major DNA damage repair kinase ATM as one of the hits. ATM



DNA Damage Response: RNA m6A regulates DNA repair

2017-04-05

Xiang et al. screened human cell lines for chromatin-associated factors that participate in the DNA damage response. Ultraviolet (UV) irradiation caused rapid and transient methylation at the 6 position of adenosine (m6A), predominantly in 5′ untranslated regions of poly(A)+ RNA,



Lipid Metabolism: Cholesterol feeds into cell growth control

2017-04-05

mTORC1 is a master regulator of cell growth, which responds to nutrient availability — in particular, amino acids. Castellano et al. now show that mTORC1 is also regulated by cholesterol, suggesting a strong link between sterol metabolism and cell growth control. Cholesterol is metabolized



Coming to grips with cell surface polarity

2017-03-30

Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses.



Plant cell development: Forcing cell polarity

2017-03-30

Mechanical tension is shown to contribute to the establishment of the cell polarity axis in plant epidermal stem cells, which is important for regulating asymmetric cell division.



DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

2017-02-22

Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically



Biomolecular condensates: organizers of cellular biochemistry

2017-02-22

Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack surrounding membranes but function to concentrate proteins and nucleic acids. These condensates are involved in diverse processes, including RNA metabolism, ribosome biogenesis, the DNA damage response and signal transduction. Recent studies have shown that liquid–liquid



Variants of core histones and their roles in cell fate decisions, development and cancer

2017-02-01

Histone variants endow chromatin with unique properties and show a specific genomic distribution that is regulated by specific deposition and removal machineries. These variants — in particular, H2A.Z, macroH2A and H3.3 — have important roles in early embryonic development, and they regulate the lineage commitment



Control of structure-specific endonucleases to maintain genome stability

2017-03-22

Structure-specific endonucleases (SSEs) have key roles in DNA replication, recombination and repair, and emerging roles in transcription. These enzymes have specificity for DNA secondary structure rather than for sequence, and therefore their activity must be precisely controlled to ensure genome stability. In this Review, we



Regulatory feedback from nascent RNA to chromatin and transcription

2017-03-08

Transcription and chromatin function are regulated by proteins that bind to DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. Unlike ncRNAs, nascent pre-mRNA was considered to be primarily a passive player in these processes. In