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Preview: Nature Reviews Molecular Cell Biology - Issue - science feeds

Nature Reviews Molecular Cell Biology


Charting the unknown epitranscriptome


RNA modifications can alter RNA structure–function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the distribution, location

Ageing: Is fat a key to longevity?


Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines.

Metabolism: Methyl groups sink into phospholipids and histones


Phospholipids and histones act as sinks for methyl groups, thereby regulating methylation reactions and contributing to metabolic homeostasis.

Cell death: ESCRTing dying cells back to life


The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death.

RNA decay: The anti-apoptotic function of ADAR1


An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay.

The moment when translational control had a theory of everything


Allan Jacobson reminds us of how a study by Dever et al. published in 1992 connected several data on translational regulation, bringing attention to its crucial role in the regulation of gene expression.

Mechanisms of diseases: Excessive polyQ tracts curb autophagy


Expansion of polyglutamine tracts in proteins interferes with the process of autophagy and may contribute to the pathology of neurodegenerative diseases.

The HSP90 chaperone machinery


The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA

The mystery of membrane organization: composition, regulation and roles of lipid rafts


Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical

Planar cell polarity in development and disease


Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by multiple global cues, including gradients of gene expression, gradients of secreted WNT ligands and anisotropic

Global treadmilling coordinates actin turnover and controls the size of actin networks


Various cellular processes (including cell motility) are driven by the regulated, polarized assembly of actin filaments into distinct force-producing arrays of defined size and architecture. Branched, linear, contractile and cytosolic arrays coexist in vivo, and cells intricately control the number, length and assembly rate