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Preview: Nature Reviews Molecular Cell Biology - Issue - science feeds

Nature Reviews Molecular Cell Biology - Issue - science feeds


Stem cells: HSC function determined by epigenetic memory


The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications.

Cell migration: Let your fingers do the walking


Cadherin-based, finger-like cell–cell contacts are shown to serve as instructive structural cues that coordinate motility during collective cell migration.

Chromatin: The chemical brothers: nucleosomes and transcription


A chemical approach for precisely mapping nucleosomes genome-wide provides novel insights into the regulation of transcription and splicing.

Protein translocation: The third route to the ER


The newly identified SND pathway is an alternative route for the targeting of proteins to the endoplasmic reticulum that functions in parallel to the SRP and GET pathways.

Cellular senescence: Senescence and reprogramming go hand-in-hand


OSKM-mediated reprogramming to pluripotency in vivo is facilitated by cellular senescence through the secretion of key cytokines.

Organelle dynamics: Controlling phase separation of P granules


Caenorhabditis elegans germ cell granules (P granules) are RNA and protein condensates that are associated with RNA metabolism. In C. elegans zygotes, P granules are spatially restricted to the posterior pole and, similarly to other non-membranous organelles, their formation is driven by liquid–liquid

Genome engineering: NHEJ and CRISPR–Cas9 improve gene therapy


The repair of DNA double-strand breaks by non-homologous end-joining (NHEJ) is efficient in non-dividing cells, but its use for site-specific transgene integration has not been shown. Suzuki et al. developed homology-independent targeted integration (HITI) for CRISPR–Cas9- and NHEJ-based gene knock-in. HITI successfully mediated site-directed

RNA decay: NoBody binds to mRNA decapping proteins


Recent studies have revealed that genomes contain thousands of small open reading frames that encode microproteins, but the functional significance of microproteins is unclear. D'Lima et al. now report the identification of a human microprotein, NoBody (non-annotated P-body dissociating polypeptide), that interacts with the

Reverse-topology membrane scission by the ESCRT proteins


The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the

Alternative polyadenylation of mRNA precursors


Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for

Post-transcriptional gene regulation by mRNA modifications


The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate

Mechanisms and in vivo functions of contact inhibition of locomotion


Contact inhibition of locomotion (CIL) is a process whereby a cell ceases motility or changes its trajectory upon collision with another cell. CIL was initially characterized more than half a century ago and became a widely studied model system to understand how cells migrate and

A view of human haematopoietic development from the Petri dish


Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human