2016-09-28In budding yeast, the association of Dhh1p with ribosomes on mRNAs enriched in non-optimal codons mediates their decay.
2016-10-06Elucidation of the mechanisms of autophagy and the work on designing molecular machines have been awarded with a 2016 Nobel Prize, in the fields of Physiology or Medicine and in Chemistry, respectively.
2016-10-05SET specifically binds to the unacetylated form of p53 to repress p53-mediated transcriptional activation.
2016-10-20Cyclin A2 ensures accurate chromosome segregation through cyclin-dependent kinase (CDK) activation, and proper DNA replication and repair through previously uncharacterized kinase-independent RNA-binding activity.
2016-09-21Microtubule depolymerization can be arrested and growth rescued at sites where the lattice is self-repaired following local damage.
2016-09-28The lipid composition of the mitochondrial membrane, in particular, synthesis of phosphatidic acid, regulates mitochondrial size by modulating fusion and fission cycles.
2016-10-05Matthias Mann describes a 1992 paper by Donald Hunt and colleagues that revolutionized the use of mass spectrometry in molecular biology.
2016-08-24The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol
2016-08-24Brown and beige adipocytes expend chemical energy to produce heat and are therefore important in regulating body temperature and body weight. Brown adipocytes develop in discrete and relatively homogenous depots of brown adipose tissue, whereas beige adipocytes are induced to develop in white adipose tissue
2016-09-21Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove catenanes and enable chromosome segregation. Human cells encode six topoisomerases (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α and TOP3β), which act on a broad range of DNA and RNA substrates at the nuclear and mitochondrial genomes. Their
2016-08-10The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes. With a direct route from the membrane to the nucleus, the Notch pathway has fewer opportunities for regulation