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Preview: Nature Reviews Molecular Cell Biology - Issue - science feeds

Nature Reviews Molecular Cell Biology - Issue - science feeds


Stem cells: Self-consumption will keep your blood young


Autophagy is shown to restrict metabolic activation of adult haematopoietic stem cells, thereby contributing to the maintenance of their quiescence and stem cell potential throughout life.

In the news


Co-culturing embryonic stem cells and trophoblast stem cells in a 3D scaffold recreates early steps of mouse embryogenesis.

Non-coding RNA: The cancer link(RNA) between PIP3 and AKT


The specific binding of the lincRNA LINK-A tothe phospholipid PIP3 and the kinase AKT activates AKT and promotes tumorigenesis and resistance to AKT inhibitors.

Epigenetics: DNA methylation prevents intragenic transcription


DNA methylation by DNMT3B within the bodies of genes prevents aberrant transcription initiation.

Cell signalling: Notch under tension


Notch signalling is a conserved pathway that regulates cell fate decisions and is initiated by binding of a transmembrane ligand (Jagged (JAG) or Delta-like (DLL)) to a Notch receptor. This binding is followed by proteolytic cleavage of the receptor, which requires molecular tension. Building on

Chromosome biology: Trimethylation of CENP-A supports mitotic fidelity


Centromeres are chromosomal sites for kinetochore assembly, which supports the attachment of spindle microtubules and chromosome segregation. The centromere is specified by the incorporation of the histone H3 variant CENP-A into nucleosomes. CENP-A interacts with components of the constitutive centromere-associated network (CCAN), which forms the

Membrane dynamics: PERKs of plasma membrane–ER communication


PRKR-like endoplasmic reticulum kinase (PERK) is an ER protein that regulates the unfolded protein response, but it has also been implicated in other cellular processes, including calcium (Ca2+) signalling. van Vliet et al. identified actin regulators as important PERK interactors in mammalian

Unclogging sickle cell anaemia


Li and Lodish describe how a shift in our understanding of the molecular basis of sickle cell anaemia has led to clinical success.

Protein metabolism: Counteracting toxic protein aggregation


Sirtuin 2 deacetylates the amino terminus of α-synuclein, thereby favouring its aggregation and toxicity associated with neurodegenerative diseases.

RNA-based recognition and targeting: sowing the seeds of specificity


RNA is involved in the regulation of multiple cellular processes, often by forming sequence-specific base pairs with cellular RNA or DNA targets that must be identified among the large number of nucleic acids in a cell. Several RNA-based regulatory systems in eukaryotes, bacteria and archaea,

Mechanisms and functions of nuclear envelope remodelling


As a compartment border, the nuclear envelope (NE) needs to serve as both a protective membrane shell for the genome and a versatile communication interface between the nucleus and the cytoplasm. Despite its important structural role in sheltering the genome, the NE is a dynamic

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer


Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby

The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain


The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II (Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the transcription process, the CTD is dynamically modified by post-translational modifications, many of which facilitate or hinder the recruitment of