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Preview: Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds





 



Synthetic biology: Designer cells tackle diabetes

2017-01-05

Two studies report on two independent synthetic biology approaches to tackle hyperglycaemia and insulin resistance that are associated with diabetes.



RNA Metabolism: Modifying sex in flies

2017-01-05

Two groups report that N6-methyladenosine (m6A) affects alternative splicing in fruit files, with notable phenotypes in sex determination and the nervous system.



Ageing: Forever young

2017-01-05

Partial reprogramming through short-term expression of OSKM reverses the ageing process in mice.



Non-Coding RNA: A class of their own

2017-01-24

The transcription and processing of long intervening noncoding RNAs (lincRNAs), which are a class of lncRNAs expressed independently of protein-coding genes, are poorly understood. Schlackow et al. studied 285 lincRNAs that are highly expressed in HeLa cells using mNET-seq, which enables monitoring of the



Development: Metabolism regulates lymphangiogenesis

2017-01-24

Wong et al. report that metabolism — more specifically, fatty acid β-oxidation (FAO) — promotes lymphatic development. They found that FAO is high in lymphatic endothelial cells (LECs; which line lymph vessels) and that inhibition or LEC-specific loss of CPT1A, which is a rate-controlling



Translation: Ubiquitylation mediates quality control

2017-01-24

Terminally stalled ribosomes can initiate degradation of nascent polypeptides and the dissociation of ribosome subunits, a process known as ribosome-associated quality control (RQC). Using a reporter that quantitatively measures ribosome terminal stalling, Juszkiewicz and Hegde found that most ribosomes in human cells stalled when they



Translation: Smoothening the coding sequence for translation

2017-01-11

A new mechanism of controlling translation initiation depends on DEAD-box RNA helicases and on RNA structures, including those present in coding sequences.



Cell death: Pulling the apoptotic trigger for necrosis

2017-01-11

Secondary necrosis following apoptosis induction is a regulated process that is dependent on the cleavage of DFNA5 by the executioner caspase, caspase 3.



The nuclear pore complex: understanding its function through structural insight

2016-12-21

Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. They are large macromolecular assemblies with a complex composition and diverse functions. Apart from facilitating nucleocytoplasmic transport, NPCs are involved in chromatin organization, the regulation of gene



Metabolic regulation of gene expression through histone acylations

2016-12-07

Eight types of short-chain Lys acylations have recently been identified on histones: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. Emerging evidence suggests that these histone modifications affect gene expression and are structurally and functionally different from the widely studied histone Lys acetylation. In



The roles of RNA processing in translating genotype to phenotype

2016-11-16

A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA levels by altering epigenetic and transcriptional regulation. Recent studies show



Histone variants on the move: substrates for chromatin dynamics

2016-12-07

Most histones are assembled into nucleosomes behind the replication fork to package newly synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are typically incorporated throughout the cell cycle. Histone variants can profoundly change chromatin properties, which in turn affect DNA replication



Necroptosis in development, inflammation and disease

2016-12-21

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a molecule already recognized as an important regulator of cell survival, inflammation and disease, was attributed an additional function: the regulation of a novel cell death pathway that came to be known as necroptosis. Subsequently,