2017-01-16This study provides insights into the archaeal ancestor of eukaryotes and the primal stages of eukaryogenesis.
2017-01-03Biogenesis of the mature bacterial ribosome requires the stepwise association of ∼50 ribosomal proteins and intricately folded rRNA, and involves ∼100 molecular chaperones. Each bacterium can generate ∼100,000 ribosomes per hour, and therefore the direct visualization of ribosome biogenesis has been challenging. Davis et al
2017-01-03Efficient replication of hepatitis C virus (HCV) in cell lines requires the acquisition of host-specific adaptive mutations; however, the molecular basis for this adaptation has remained unsolved. Harak et al. report that adaptive mutations in the genes encoding viral NS5A and NS5B regulate the
2017-01-03Malaria parasites traverse through various cells within their human hosts and mosquito vectors to complete their life cycles. Although the mosquito cell traversal protein for ookinetes and sporozoites (CelTOS) is an essential protein for traversal of malaria parasites, and thus critical for the transmission and
2016-12-28Two new studies provide insights into the close association between Wolbachia spp. and their hosts; one shows plant-mediated transmission and the other the bacterial origin of a new host sex chromosome.
2017-01-03This paper shows that the intestinal microbiota is required for normal expansion of the pancreatic β-cell population in zebrafish during early larval development.
2016-12-19This study shows that circadian changes in the gut microbiota influence host physiology in the intestine and the liver.
2017-01-16This month's Genome Watch discusses how whole-genome sequencing of bacteria from several body sites has provided insights into the spatial diversity of bacteria within patients.
2016-12-12To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed viral DNA. The nucleus is a complex environment, in which chromatin is organized to support different structural and functional aspects of cell physiology. As such, it represents a challenge for
2016-12-12Cellulosomes are multienzyme complexes that are produced by anaerobic cellulolytic bacteria for the degradation of lignocellulosic biomass. They comprise a complex of scaffoldin, which is the structural subunit, and various enzymatic subunits. The intersubunit interactions in these multienzyme complexes are mediated by cohesin and dockerin
2016-11-21Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal morphologies in C. albicans was thought to underlie much of the variation in virulence observed in different host
2017-01-03Infections are estimated to contribute to 20% of all human tumours. Viruses are known to induce cell transformation, but evidence has also linked bacteria, such as Helicobacter pylori and Salmonella enterica subsp. enterica serovar Typhi, to different cancer types. In addition, Chlamydia
2016-12-28Nature Reviews Microbiology14, 205–220 (2016)It has recently come to the authors' attention that this Review is the first place in which Figure 1 was published. Yi-Wei Chang, who collected the data for Figure 1 and helped to