Subscribe: Nature Reviews Microbiology - Issue - science feeds
Preview: Nature Reviews Microbiology - Issue - science feeds

Nature Reviews Microbiology - Issue - science feeds


Virus Infection: HIV-1 weighs up risks and benefits


This study investigated the role of IFITM proteins in the restriction of HIV-1 strains that have different receptor tropism and identified IFITM proteins as major effectors of the innate immune response.

Archaeal biology: Archaeal virus escapology


Visualization of the morphogenesis and egress of a prototypical archaeal virus reveals some key similarities with eukaryotic viruses.

Bacterial physiology: A new chaperone for regulatory sRNAs


ProQ is revealed to be a global post-transcriptional regulator that stabilizes structured RNAs.

Marine microbiology: UCYN-A fixes N2 in the sea


Species in the cyanobacterial genus Trichodesmium are considered to be the main contributors to microbial dinitrogen (N2) fixation in the ocean. However, Martínez-Pérez et al. now show that the symbiotic cyanobacterium UCYN-A, which associates with eukaryotic algae, also fixes N2

Structural biology: Zooming in on F pili


Despite the importance of the bacterial F pilus in DNA transfer and as an entry point for phages, its structure was unknown. Costa et al. now solve the structure of two plasmid-purified F family pili — the pED208 and F pili — at 3.6

Antimicrobials: Hitting malaria on several levels


Current antimalarial drugs cannot target all stages of the Plasmodium spp. lifecycle and are challenged by drug-resistant strains of Plasmodium falciparum. Kato et al. sought more effective drugs against this parasite by testing synthetic compounds, the structures of which were based on

Bacterial secretion: Reusing injected proteins


This study shows that T6SS components that are transferred between cells can be reused to assemble a fucntional T6SS system in the recipient.

Bacterial toxins: TcdB aims for Frizzled


This study reveals that TcdB binds to two different receptors, CSPG4 and FZD, in a cell type-dependent manner.

Antimicrobials: Pump it out


The tripartite efflux pump CmeABC is the most important efflux system in Campylobacter spp. that confers multidrug resistance. Yao, Shen et al. report the identification of a CmeABC variant that exhibits enhanced efflux function. This variant, termed resistance-enhancing CmeABC (RE-CmeABC), was more potent

Bacterial pathogenesis: Spirochete spreading


The ability of Treponema pallidum to disseminate throughout the host and exit from the vasculature is crucial to its pathogenesis. This process is governed by T. pallidum proteins, including TP0751 (also known as pallilysin), that mediate attachment to the host extracellular matrix (ECM).

Archaeal genomics: Divergent methanogenic archaea


Methanogenic anaerobic archaea produce the largest amount of methane on Earth. Methane metabolism was thought to originate early in the evolution of the phylum Euryarchaeota, a notion that was challenged following the discovery of putative methane metabolism in the archaeal phylum Bathyarchaeota. Vanwonterghem et al

Sending a message: extracellular vesicles of pathogenic protozoan parasites


Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules through EVs, pathogenic protozoans are able to establish infective niches, modulate the immune system of

ESX secretion systems: mycobacterial evolution to counter host immunity


Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as type VII secretion systems), to export a set of effector proteins that helps the pathogen to resist or evade the host immune

Harnessing the power of microbial autotrophy


Autotrophic microorganisms convert CO2 into biomass by deriving energy from light or inorganic electron donors. These CO2-fixing microorganisms have a large, but so far only partially realized, potential for the sustainable production of chemicals and biofuels. Productivities have been improved in

Zika virus — reigniting the TORCH


The recent association between Zika virus (ZIKV) infection during pregnancy and fetal microcephaly has led to a renewed interest in the mechanisms by which vertically transmitted microorganisms reach the fetus and cause congenital disease. In this Opinion article, we provide an overview of the structure

Division of labour in microorganisms: an evolutionary perspective


The division of labour, whereby individuals within a group specialize in certain tasks, has long been appreciated as central to the evolution of complex biological societies. In recent years, several examples of division of labour in microorganisms have arisen, which suggests that this strategy may