Subscribe: Nature Reviews Immunology - Issue - science feeds
Preview: Nature Reviews Immunology - Issue - science feeds

Nature Reviews Immunology - Issue - science feeds


Prime–boost strategies to embrace diversity and inclusion in immunology


Immunologists appreciate the need for creative approaches to tackle complex scientific questions, which can involve not only the use of novel technologies but also the experience of scientists from diverse backgrounds. Here, we highlight measures to prime for the inclusion of women and underrepresented individuals

T cells: A tissue checkpoint for TH2s


A cell-intrinsic checkpoint restricts type 2 cytokine production by ILC2s and TH2 cells at sites of tissue damage.

Infection: Zika virus: end of transmission?


Broadly neutralizing human antibodies for Zika virus protect adult mice and prevent maternal–fetal transmission.

Macrophages: Granuloma macrophage differentiation


Multinuclear granuloma macrophages arise through a distinct differentiation pathway mediated by chronic TLR2 signalling, rather than by cell fusion.

Macrophages: Shaping good eating habits


Macrophages regulate phagocytic and inflammatory responses by non-professional phagocytes.

Infection: Interferons suppress antibody responses


Type I interferons induced by chronic viral infections suppress the induction of early neutralizing antibody responses.

Macrophages: Macrophage muscle man


Macrophages expressing PPARγ support skeletal muscle regeneration by inducing secretion of the myoblast growth factor GDF3.

A Third signal from Conditioned DCs dictates microbial effector choice


Alan Sher describes a 2002 paper by Martien Kapsenberg and Pawel Kalinski that provided evidence for the conditioning of DCs by microbial compounds to promote TH1 or TH2 cell responses.

Immunoregulation by members of the TGFβ superfamily


The transforming growth factor-β (TGFβ) superfamily is encoded by 33 genes and includes TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized as a crucial regulator of immune responses, the immunoregulatory functions of other TGFβ family members are less clear. However, recent

Emerging roles of p53 and other tumour-suppressor genes in immune regulation


Tumour-suppressor genes are indispensable for the maintenance of genomic integrity. Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have been implicated in immune responses and inflammatory diseases. In particular, the p53 tumour- suppressor pathway is involved in crucial aspects of

Food allergy: immune mechanisms, diagnosis and immunotherapy


Food allergy is a pathological, potentially deadly, immune reaction triggered by normally innocuous food protein antigens. The prevalence of food allergies is rising and the standard of care is not optimal, consisting of food-allergen avoidance and treatment of allergen-induced systemic reactions with adrenaline. Thus, accurate

Do antibodies select a healthy microbiota?


Disruptions to the microbiota can have pathological consequences, which highlights the need to understand the factors that contribute to its stability. Although decades of research have focused on the importance of IgA during pathogenic infection, much of the IgA that is generated in the gut