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Nature Reviews Immunology


Regulatory T cells: Subset-specific suppression


T-bet+ regulatory T cells form a stable subset with specific suppressive activity towards T-bet+ effector T cells.

Tumour Immunology: LAP targeting reduces tolerogenic cells in cancer


Anti-LAP antibodies show promising anticancer properties.

Regulatory T cells: Keep your hair on


Regulatory T cells modulate the hair follicle regeneration cycle by inducing stem cell proliferation and differentiation.

Germinal centres: An ephrin B1-based guidance system


Ephrin B1 controls T follicular helper cell residence and function in germinal centres.

Antiviral immunity: IFNλ offers frontline protection


Lambda interferons have a non-redundant role in protecting airway epithelial cells from influenza A virus infection without inducing immunopathology.

T cells: Staying alive with S1P


Sphingosine 1-phosphate promotes naive T cell survival by supporting their mitochondrial function.

Neuroendrocrine effects on autoimmunity


Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology.

The immunopathology of sepsis and potential therapeutic targets


Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by

Altered B cell signalling in autoimmunity


Recent work has provided new insights into how altered B cell-intrinsic signals — through the B cell receptor (BCR) and key co-receptors — function together to promote the pathogenesis of autoimmunity. These combined signals affect B cells at two distinct stages: first, in the selection

BACH transcription factors in innate and adaptive immunity


BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread roles of BACH proteins in controlling the development and function of the innate and adaptive immune systems, including the differentiation of effector

Does niche competition determine the origin of tissue-resident macrophages?


Most tissue-resident macrophages are derived from embryonic precursors but, under certain circumstances, circulating monocytes can differentiate into self-maintaining tissue-resident macrophages that resemble their embryonic counterparts. In this Opinion article, we propose that distinct macrophage precursors have an almost identical potential to develop into resident macrophages