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Preview: Nature Reviews Immunology - Issue - nature.com science feeds

Nature Reviews Immunology - Issue - nature.com science feeds





 



Immunometabolism: Stress-induced macrophage polarization

2017-04-10

Activation of the IRE1α-mediated stress response pathway in adipose tissue macrophages suppresses M2 polarization.



Neuroimmunology: Immune signals packaged in the brain

2017-04-26

Astrocyte-shed extracellular vesicles provide long-distance messages to promote peripheral immune responses following brain injury.



Insect Immunity: Mechanism of adaptive immunity found in the fruitfly

2017-04-26

Haemocytes in Drosophila melanogaster facilitate antiviral immunity by amplifying and systemically disseminating RNA interference-mediated responses via exosome-like vesicles. Moreover, they allow for immune memory, akin to adaptive immune responses in mammals.



Microbiota: Diet can protect against type 1 diabetes

2017-04-19

Microbial metabolites can protect mice from diabetes by decreasing the frequency of autoreactive T cells and promoting the frequency of regulatory T cells.



Finding order in chaos

2017-04-03

Linda Sherman describes a 1991 study by Hans-Georg Rammensee and colleagues that defines allele-specific motifs required for the binding of peptides to MHC molecules.



Cytokines: Oncostatin M – a new target in IBD?

2017-04-26

Oncostatin M promotes intestinal inflammation and can predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases.



Mechanisms of central tolerance for B cells

2017-04-03

Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of



Generation of diversity in thymic epithelial cells

2017-03-20

In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells. Here, we review the expanding diversity in TEC subpopulations in



Liver macrophages in tissue homeostasis and disease

2017-03-20

Macrophages represent a key cellular component of the liver, and are essential for maintaining tissue homeostasis and ensuring rapid responses to hepatic injury. Our understanding of liver macrophages has been revolutionized by the delineation of heterogeneous subsets of these cells. Kupffer cells are a self-sustaining,



New insights into mononuclear phagocyte biology from the visual system

2017-03-27

Major advances in mononuclear phagocyte biology have been made but key questions pertinent to their roles in health and disease remain, including in the visual system. One problem concerns how dendritic cells can trigger immune responses from certain tightly regulated immune- privileged sites of the



Programmed cell death and the immune system

2017-02-06

More than 50 years ago, cells were observed to die during insect development via a process that was named 'programmed cell death'. Later, a similar cell death process was found to occur in humans, and the process was renamed 'apoptosis'. In the 1990s, a number