2016-12-12Pollutants activate the aryl hydrocarbon receptor to upregulate type 2 cytokines and neurotrophic factors that drive atopic dermatitis.
2016-12-23B cells may protect against pre-term labour by responding to IL-33.
2016-12-23Expression of CX3CR1 defines a new memory T cell subset that surveys peripheral tissues.
2016-12-05Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease.
2016-12-05Two studies have characterized a distinct molecular signature of intratumoral CD4+ regulatory T cells from various tumours that correlates with cancer prognosis.
2016-12-12Thymic stromal lymphopoietin increases the killing of methicillin-resistant Staphylococcus aureus in a neutrophil- and complement-dependent manner.
2016-12-12The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications.
2016-11-28The respiratory immune response consists of multiple tiers of cellular responses that are engaged in a sequential manner in order to control infections. The stepwise engagement of effector functions with progressively increasing host fitness costs limits tissue damage. In addition, specific mechanisms are in place
2016-12-05The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of
2016-11-28Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune responses. Recent comprehensive studies have highlighted the importance of DC migration in the maintenance of immune surveillance and
2016-12-05Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The
2016-12-05Patients with rheumatoid arthritis can be divided into two major subsets characterized by the presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of rheumatoid factor (RF). The antibody-positive subset of disease, also known as seropositive rheumatoid arthritis, constitutes approximately two-thirds of all