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Preview: Nature Reviews Immunology - Issue - science feeds

Nature Reviews Immunology


Emil von Behring: translational medicine at the dawn of immunology


On 31st March 1917, Emil von Behring passed away. Why is this event so important for immunologists a century later?

Immune regulation: IL-10 targets macrophage metabolism


The anti-inflammatory effects of IL-10 involve mTORC1-regulated metabolic and autophagic pathways in macrophages.

Neuroimmunology: Macrophages help you burn energy


Macrophages in brown adipose tissue support sympathetic innervation to ensure proper homeostatic energy expenditure.

Asthma and allergy: The NET effect of respiratory viruses


Rhinovirus infections exacerbate asthma by inducing the release of neutrophil extracellular traps.

Tumour immunology: Immune atlas sheds light on anticancer responses


Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment.

Medullary Thymic epithelial cell progenitors: hidden in plain sight


Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors.

Tumour immunology: Platelets — a new target in cancer immunotherapy?


Activation of TGFβ by platelets limits the efficacy of anti-tumour T cell responses.

Monocyte differentiation and antigen-presenting functions


Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their

Mitochondrial DNA in innate immune responses and inflammatory pathology


Mitochondrial DNA (mtDNA) — which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases — is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytoplasm, extracellular space or

Multi-receptor detection of individual bacterial products by the innate immune system


The receptors of the innate immune system detect specific microbial ligands to promote effective inflammatory and adaptive immune responses. Although this idea is well appreciated, studies in recent years have highlighted the complexity of innate immune detection, with multiple host receptors recognizing the same microbial

Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them


Memory-phenotype CD8+ T cells exist in substantial numbers within hosts that have not been exposed to either foreign antigen or overt lymphopenia. These antigen-inexperienced memory-phenotype T cells can be divided into two major subsets: 'innate memory' T cells and 'virtual memory' T cells.

Immunosuppressive cell death in cancer


Harnessing the fundamental machinery of the immune system provides an opportunity to cure cancer, and this has led oncologists to turn their attention to the interface between therapeutic strategies, cancer cell death and the immunological consequences. In their recent Review article (Immunogenic cell death

Reply: Immunosuppressive cell death in cancer


In our recent Review (Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol.17, 97–111 (2017)), we discussed the molecular and cellular processes through which the death of infected and malignant cells can initiate an adaptive immune response against