2016-08-30Single-cell genomic analysis of ILCs from the mouse small intestine identifies high levels of diversity that are maintained by the commensal microbiota.
2016-09-12Interleukin-1β is activated by the group A Streptococcus protease SpeB during infection.
2016-09-27The genome of germinal centre B cells undergoes a multilayered reorganization to coordinate transcriptional reprogramming.
2016-09-12The lncRNA Morrbid controls the lifespan of short-lived myeloid cells.
2016-09-19Regulatory variant of peptidoglycan recognition receptors in Drosophila resolve immune responses according to threat level.
2016-09-19There are no obvious clinical symptoms of long-term deficiency of innate lymphoid cells in humans, which suggests that their postulated functions might be redundant.
2016-09-27Fasting metabolism has opposing roles in maintaining tissue tolerance; anorexia improves survival during bacterial infection whereas it has detrimental effects during viral infection.
2016-08-16Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the
2016-08-30T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce
2016-08-22Males and females differ in their immunological responses to foreign and self-antigens and show distinctions in innate and adaptive immune responses. Certain immunological sex differences are present throughout life, whereas others are only apparent after puberty and before reproductive senescence, suggesting that both genes and
2016-08-08A number of mechanisms ensure that the intestine is protected from pathogens and also against our own intestinal microbiota. The outermost of these is the secreted mucus, which entraps bacteria and prevents their translocation into the tissue. Mucus contains many immunomodulatory molecules and is largely
2016-08-01The year 2016 marks 100 years since the death of Élie Metchnikoff (1845–1916), the Russian zoologist who pioneered the study of cellular immunology and who is widely credited with the discovery of phagocytosis, for which he was jointly awarded the Nobel Prize in Physiology or