2017-01-23Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease.
2017-01-03Different microbial stimuli lead to specific metabolic programmes in activated human monocytes.
2017-01-23Plasma cells accumulate in the ageing thymus and may provide protection against viral infections.
2017-01-03NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K–AKT–mTOR pathway.
2017-01-03Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure.
2017-01-31A T cell receptor signalling inhibitor shows efficacy in autoimmune diseases without affecting immune responses to pathogens.
2017-01-31Chewing induces the accumulation of T helper 17 cells in the mouth.
2017-01-03The immune system probably evolved to limit the negative effects exerted by pathogens on host homeostasis. This defence strategy relies on the concerted action of innate and adaptive components of the immune system, which sense and target pathogens for containment, destruction or expulsion. Resistance to
2016-10-17Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death.
2016-12-28Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors — which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins — modulate and antagonize signalling by canonical effector–receptor
2016-12-19Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1
2016-12-28We recently came across a Review (Nat. Rev. Immunol. doi: 10.1038/nri.2016.107 (2016)) published in your distinguished journal. We completely agree with the authors' statement that immunogenic cell death (ICD), whether occurring in cancer cells or pathogen infection, requires the two key
2016-12-28We have recently reviewed current knowledge on the mechanisms that underlie immunogenic cell death (ICD) in the context of cancer and infectious diseases, the capacity of ICD to elicit an adaptive immune response in the absence of exogenous adjuvants, and the pathophysiological relevance of this