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Preview: Nature Reviews Genetics - Issue - science feeds

Nature Reviews Genetics - Issue - science feeds


Genome organization: Zooming in on nuclear organization


Chromatin conformation capture (3C) and its derivatives have provided insight into the three-dimensional (3D) organization of the nucleus. However, their ability to identify simultaneous chromatin contacts and to assess genome structure at the single-cell level was limited. Now, Beagrie et al. report a method

Regulatory elements: A boost to RNA processing


The term 'super-enhancer' is used to denote clusters of enhancer elements that are bound by a high concentration of cell type-specific master transcription factors and that drive the transcription of genes involved in cell-type identity and disease pathogenesis. A new study published in Cell

Genetic variation: Linear INSIGHTs into non-coding DNA


Genetic variants that are associated with disease often lie outside of protein-coding genes, and accurately characterizing variation within non-coding regions of the human genome remains challenging. Now, Huang et al. present a new computational method, Linear INSIGHT (LINSIGHT), which can predict non-coding disease-causing variants.

Disease genomics: Transitioning from association to causation with eQTLs


In the quest to identify genetic causes of disease, attention is turning increasingly to expression quantitative trait loci (eQTLs), which associate DNA sequence variation with changes in gene expression. Most efforts to identify causal eQTLs focus on cis-eQTLs (which affect expression of nearby genes),

Genetic screens: CRISPR-based mapping of genetic interactions


We often conceptualize genes as independent units of information, although their behaviour is influenced by interactions with other genes. Now, two independent studies present scalable double-knockout CRISPR-based screens for mapping pairwise genetic interactions and apply these to the identification of effective synergistic drug combinations in

RNA: Translated circular RNAs


Two studies published in Molecular Cell provide in vitro and in vivo evidence for the cap-independent translation of circular RNAs (circRNAs) in multiple metazoan species.circRNAs are known to be evolutionarily conserved and highly abundant, but few have been functionally validated. circRNAs

Gene regulation: The nuclear pore — a scaffold for inducible genes


The nuclear pore complex (NPC) is known to directly interact with chromatin and to influence transcription, but the mechanistic roles of its subunits in regulating gene expression were unclear. Pascual-Garcia et al. now show that NPCs can bind to inducible genes and that its

Synthetic Biology: Building a custom eukaryotic genome de novo


The Synthetic Yeast Project (Sc2.0) aims to create the first synthetic eukaryotic genome. It is based on synthesizing, from scratch, a reworked Saccharomyces cerevisiae genome that is optimized for genomic stability and includes various design features to make it an easily engineerable chassis for

Detecting RNA modifications in the epitranscriptome: predict and validate


RNA modifications are emerging players in the field of post-transcriptional regulation of gene expression, and are attracting a comparable degree of research interest to DNA and histone modifications in the field of epigenetics. We now know of more than 150 RNA modifications and the true

Integration site selection by retroviruses and transposable elements in eukaryotes


Transposable elements and retroviruses are found in most genomes, can be pathogenic and are widely used as gene-delivery and functional genomics tools. Exploring whether these genetic elements target specific genomic sites for integration and how this preference is achieved is crucial to our understanding of

Transplant genetics and genomics


Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the