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Preview: Nature Reviews Genetics - Issue - science feeds

Nature Reviews Genetics - Issue - science feeds


Gene expression: Host–pathogen duels revealed by dual RNA-seq in vivo


Dual RNA sequencing (RNA-seq) provides a powerful means for obtaining detailed insights into host and pathogen gene expression responses simultaneously and from the same samples. Building on earlier applications of dual RNA-seq in cell culture, new studies apply dual RNA-seq in vivo to uncover

Genetic variation: Giving context to phenotype prediction


One of the central challenges facing both basic biology and advanced bioengineering is understanding how genetic variation leads to phenotypic effects. Researchers have turned to powerful bioinformatic technologies that can assess thousands of mutations in parallel. However, these 'deep mutational scans' are difficult to scale,

Technique: SMiLE-seq illuminates transcription factor motifs


A study published recently in Nature Methods describes a new technique, called selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), which enables the rapid identification of the binding motifs of single and dimeric transcription factors (TFs).Existing methods that probe protein–DNA interactions have characterized

Non-coding RNA: Pri-miRNA processing: structure is key


MicroRNAs (miRNAs) are processed from hairpin-containing primary transcripts (pri-miRNA), but how pri-miRNAs are selected for processing given the ubiquity of hairpin motifs in non-coding transcripts is poorly understood. A new computational study with experimental validation in Genome Research has identified several features that are

Metagenomics: Uncultivated microbes reveal new CRISPR–Cas systems


The domestication of the class II CRISPR–Cas system has revolutionized molecular biology by allowing targeted editing of specific sequences in the genome. However, the CRISPR–Cas technologies currently in use are derived from isolated bacterial species, despite these 'bacterial immune systems' being widespread in nature. Now,

Cancer genomics: Keeping score with immunotherapy response


Immunotherapy has a substantial impact on the outcome of some cancers, but its potential is limited because only a minority of patients respond to treatment. Thus, a major motivation in the field is to identify 'signatures' that might predict with high confidence those tumours that

Down syndrome and the complexity of genome dosage imbalance


Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic gain dosage imbalances, including microduplications. The functional genomic exploration of the post-sequencing years of chromosome 21, and the generation of numerous cellular and mouse models, have provided an unprecedented opportunity

Transcriptional architecture of the mammalian circadian clock


Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription–translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide

Ground rules of the pluripotency gene regulatory network


Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected

Chromatin dynamics during the cell cycle at centromeres


Centromeric chromatin undergoes major changes in composition and architecture during each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in mitosis to ensure proper chromosome segregation. Thus, proper orchestration of centromeric chromatin dynamics during interphase, including replication in S phase, is crucial. We