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Preview: Nature Reviews Genetics - Issue - nature.com science feeds

Nature Reviews Genetics - Issue - nature.com science feeds





 



Gene expression: Host–pathogen duels revealed by dual RNA-seq in vivo

2017-02-15

Dual RNA sequencing (RNA-seq) provides a powerful means for obtaining detailed insights into host and pathogen gene expression responses simultaneously and from the same samples. Building on earlier applications of dual RNA-seq in cell culture, new studies apply dual RNA-seq in vivo to uncover



Genetic variation: Giving context to phenotype prediction

2017-01-31

One of the central challenges facing both basic biology and advanced bioengineering is understanding how genetic variation leads to phenotypic effects. Researchers have turned to powerful bioinformatic technologies that can assess thousands of mutations in parallel. However, these 'deep mutational scans' are difficult to scale,



Technique: SMiLE-seq illuminates transcription factor motifs

2017-01-31

A study published recently in Nature Methods describes a new technique, called selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), which enables the rapid identification of the binding motifs of single and dimeric transcription factors (TFs).Existing methods that probe protein–DNA interactions have characterized



Non-coding RNA: Pri-miRNA processing: structure is key

2017-01-31

MicroRNAs (miRNAs) are processed from hairpin-containing primary transcripts (pri-miRNA), but how pri-miRNAs are selected for processing given the ubiquity of hairpin motifs in non-coding transcripts is poorly understood. A new computational study with experimental validation in Genome Research has identified several features that are



Metagenomics: Uncultivated microbes reveal new CRISPR–Cas systems

2017-01-23

The domestication of the class II CRISPR–Cas system has revolutionized molecular biology by allowing targeted editing of specific sequences in the genome. However, the CRISPR–Cas technologies currently in use are derived from isolated bacterial species, despite these 'bacterial immune systems' being widespread in nature. Now,



Cancer genomics: Keeping score with immunotherapy response

2017-01-23

Immunotherapy has a substantial impact on the outcome of some cancers, but its potential is limited because only a minority of patients respond to treatment. Thus, a major motivation in the field is to identify 'signatures' that might predict with high confidence those tumours that



Down syndrome and the complexity of genome dosage imbalance

2016-12-28

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic gain dosage imbalances, including microduplications. The functional genomic exploration of the post-sequencing years of chromosome 21, and the generation of numerous cellular and mouse models, have provided an unprecedented opportunity



Transcriptional architecture of the mammalian circadian clock

2016-12-19

Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription–translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide



Ground rules of the pluripotency gene regulatory network

2017-01-03

Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected



Chromatin dynamics during the cell cycle at centromeres

2017-01-31

Centromeric chromatin undergoes major changes in composition and architecture during each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in mitosis to ensure proper chromosome segregation. Thus, proper orchestration of centromeric chromatin dynamics during interphase, including replication in S phase, is crucial. We