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Preview: Nature Reviews Genetics - Issue - science feeds

Nature Reviews Genetics - Issue - science feeds


Population genomics: Off the beaten track


Four new next-generation sequencing studies in ancient and modern humans report genomic insights from a large number of geographically diverse populations, adding greater detail to our picture of human genetic variation and population history.The development of next-generation sequencing technologies has provided unprecedented power for

Disease genetics: Under pressure — genetics of hypertension


Elevated blood pressure, or hypertension, is associated with substantial morbidity and mortality worldwide. The identification of new anti-hypertensive therapeutic targets, by elucidating novel genetic factors and mechanistic pathways underlying blood pressure regulation, has therefore been a major goal of ongoing research efforts. Three new studies

Mobile elements: Putting the brakes on ageing


A new study in Drosophila melanogaster reports that ageing-related changes in heterochromatin lead to the activation of transposable elements (TEs). This activation can be suppressed by dietary, genetic or pharmacological interventions to extend longevity.In fruitflies, ageing is associated with the loss of repressive

Genetic screens: A global map of genetic interactions


Functional interactions between genes can reveal gene roles and interdependencies, but comprehensive studies are a major undertaking owing to the combinatorial complexity of generating double mutants for each pairwise interaction tested. A new large-scale study analyses >23 million double-mutant yeast strains to generate a multilayered

Metagenomics: Marine genomics goes viral


The systematic collection and processing of the global ocean virome (GOV) data set, now reported in Nature, reveals the underlying structure of marine viral communities worldwide, providing an unprecedented view into the genetic diversity of double-stranded DNA (dsDNA) viruses.Viruses are thought to play

Genetic engineering: Allele-specific genome editing of disease loci


A goal in the treatment of Huntington disease, an autosomal dominant disorder caused by a gain-of-function mutation in one allele of the huntingtin (HTT) gene, is to inactivate the harmful mutant allele without affecting the normal version that is required for cell integrity.

Organization and function of the 3D genome


Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and

Detecting circular RNAs: bioinformatic and experimental challenges


The pervasive expression of circular RNAs (circRNAs) is a recently discovered feature of gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect genome-wide circRNA expression from RNA sequencing (RNA-seq) data have been developed in the past few years, but there is

Transition states and cell fate decisions in epigenetic landscapes


Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the relationship between gene activity and cell fates during development. Over the past few years, it has become a useful framework for interpreting results from single-cell transcriptomics experiments. It has led to the proposal

Genetic drift, selection and the evolution of the mutation rate


As one of the few cellular traits that can be quantified across the tree of life, DNA-replication fidelity provides an excellent platform for understanding fundamental evolutionary processes. Furthermore, because mutation is the ultimate source of all genetic variation, clarifying why mutation rates vary is crucial