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Preview: Nature Reviews Cancer - Issue - nature.com science feeds

Nature Reviews Cancer - Issue - nature.com science feeds





 



Cell migration: Shall we travel together?

2017-03-10

Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin–N-cadherin adherens junction promotes cancer cell invasion.



Immunotherapy: Engineered T cells for all

2017-03-03

A report in Science Translational Medicine provides the first example of using universal engineered chimeric antigen receptor (CAR) T cells from human leukocyte antigen (HLA)-mismatched donors.



Genomics: A different view of the landscape

2017-03-10

Using data from The Cancer Genome Atlas, Carter et al. find that germline variations can influence tumour sites of origin and somatic mutations.



Epigenetics: Addicted to reading

2017-03-23

Two papers find that the histone acetylation reader function of the YEATS domain of ENL is required to sustain oncogenic transcriptional programmes for the growth and disease maintenance of acute leukaemias.



Targeting neoantigens to augment antitumour immunity

2017-02-24

The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). These neoantigens



Liquid biopsies come of age: towards implementation of circulating tumour DNA

2017-02-24

Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and



Tissue-specific tumorigenesis: context matters

2017-03-03

How can we treat cancer more effectively? Traditionally, tumours from the same anatomical site are treated as one tumour entity. This concept has been challenged by recent breakthroughs in cancer genomics and translational research that have enabled molecular tumour profiling. The identification and validation of



Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy

2017-03-10

The Opinion article from Gabriel Ichim and Stephen W. G. Tait, 'A fate worse than death: apoptosis as an oncogenic process' (Nat. Rev. Cancer16, 539–548; 2016), highlights intrinsic mechanisms of failure of commonly used cancer therapies that are heavily dependent



Cancer therapy-induced PAFR ligand expression: any role for caspase activity?

2017-03-10

Our recent Opinion article discussed the oncogenic effects of engaging apoptosis and their impact on cancer (Nat. Rev. Cancer16, 539–548; 2016). We would like to thank Roger Chammas, Luciana Nogueira de Sousa Andrade and Sonia Jancar for their correspondence on our



Interrogating open issues in cancer precision medicine with patient-derived xenografts

2017-01-20

Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and



Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

2017-03-23

Nature Reviews Cancer17, 79–92 (2017)In this article a source of grant funding for one of the authors was omitted from the Acknowledgements section. The online version of the article has been corrected to include: “The work of



A chemical probe toolbox for dissecting the cancer epigenome

2017-03-23

Nature Reviews Cancer17, 160–183 (2017)Supplementary information S1–S6 (tables) for this article have been replaced, with several minor errors in the tables and references corrected.