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Nature Reviews Cancer - Issue - nature.com science feeds





 



Tumour Suppressors: Following the clues of cancer-resistant tissues

2017-04-24

Using gene expression analyses of cancer-resistant differentiated muscle cells, Keckesova et al. identify a mitochondrial protein, lactamase β (LACTB), that affects lipid metabolism and can induce differentiation and suppress proliferation of breast cancer cells in vitro and in vivo.



Metastasis: Breaching barriers

2017-04-07

Boire et al. describe a mechanism by which cancer cells can survive and grow in the leptomeninges of the brain by upregulating complement component 3 (C3) to disrupt blood–cerebrospinal fluid barrier function, allowing entry of growth-promoting factors.



Microbiota: a key orchestrator of cancer therapy

2017-03-17

The microbiota is composed of commensal bacteria and other microorganisms that live on the epithelial barriers of the host. The commensal microbiota is important for the health and survival of the organism. Microbiota influences physiological functions from the maintenance of barrier homeostasis locally to the



Prospects for combining targeted and conventional cancer therapy with immunotherapy

2017-03-24

Over the past 25 years, research in cancer therapeutics has largely focused on two distinct lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clinically important targeted agents that result in profound,



Pre-metastatic niches: organ-specific homes for metastases

2017-03-17

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors



Advances and challenges in targeting FGFR signalling in cancer

2017-03-17

Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed



New frontiers in translational control of the cancer genome

2017-04-24

Nature Reviews Cancer16, 288–30410.1038/nrc.2016.27 (2016)In this Review, in Figure 1, for both the figure and figure legend 'eIF4B' was incorrectly labelled as 'eIF2B'. The paper has been corrected online.



Leukaemia: 'Gimme shelter'

2017-04-24

Leukaemia