2017-04-24Using gene expression analyses of cancer-resistant differentiated muscle cells, Keckesova et al. identify a mitochondrial protein, lactamase β (LACTB), that affects lipid metabolism and can induce differentiation and suppress proliferation of breast cancer cells in vitro and in vivo.
2017-04-07Boire et al. describe a mechanism by which cancer cells can survive and grow in the leptomeninges of the brain by upregulating complement component 3 (C3) to disrupt blood–cerebrospinal fluid barrier function, allowing entry of growth-promoting factors.
2017-03-17The microbiota is composed of commensal bacteria and other microorganisms that live on the epithelial barriers of the host. The commensal microbiota is important for the health and survival of the organism. Microbiota influences physiological functions from the maintenance of barrier homeostasis locally to the
2017-03-24Over the past 25 years, research in cancer therapeutics has largely focused on two distinct lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clinically important targeted agents that result in profound,
2017-03-17It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors
2017-03-17Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed
2017-04-24Nature Reviews Cancer16, 288–30410.1038/nrc.2016.27 (2016)In this Review, in Figure 1, for both the figure and figure legend 'eIF4B' was incorrectly labelled as 'eIF2B'. The paper has been corrected online.