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Preview: Nature Reviews Cancer - Issue - science feeds

Nature Reviews Cancer


Immunotherapy: T cells get a ride


Strategies that inhibit the immune checkpoint blockade (ICB) and reactivate T cells using monoclonal antibodies against programmed cell death protein 1 (PD1) and PD1 ligand 1 (PDL1) have been used to successfully treat immunogenic tumours, and recent efforts have focused on combining this approach with

The ETS family of oncogenic transcription factors in solid tumours


Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory complexes and novel cis-acting mutations in ETS

Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy


The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. The outcome

The calcium–cancer signalling nexus


The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past

Genetics: Gender-specific factors in cancer susceptibility


Two studies published in Nature Genetics have delved into the complex genetics of cancer susceptibility and have shown links of both timing of puberty onset and mosaic loss of chromosome Y (mLOY) to cancer risk.Previous genomic analyses have indicated various genetic factors associated

Immunotherapy: Programming T cells in situ


Adoptive T cell therapy with patient-derived cells engineered ex vivo to express chimeric antigen receptors (CARs) is a promising therapeutic strategy in cancer, but producing these cells for a large number of patients is both technically challenging and cost prohibitive. Smith et al.

Tumorigenesis: Cancer as a symptom of evolution?


A paper in Science by Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types.

Metastasis: The plastic state


ZEB1-mediated epithelial-mesenchymal transition (EMT) and cellular plasticity promotes metastasis in pancreatic cancer.

RNA editing-dependent epitranscriptome diversity in cancer stem cells


Cancer stem cells (CSCs) can regenerate all facets of a tumour as a result of their stem cell-like capacity to self-renew, survive and become dormant in protective microenvironments. CSCs evolve during tumour progression in a manner that conforms to Charles Darwin's principle of natural selection.