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aberrant activity  cancer  cell cycle  cell  cells  cycle proteins  cycle  metastasis  precision medicine  proteins  tumour cell  tumour 
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Preview: Nature Reviews Cancer - Issue - nature.com science feeds

Nature Reviews Cancer - Issue - nature.com science feeds





 



Metastasis: Planting metastasis early

2017-01-27

Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+ breast cancer are more likely to seed metastasis than those from established tumours.



Oncogenes: Coping with stress

2017-01-27

Grabocka and Bar-Sagi have shown that cells expressing mutant KRAS upregulate SGs in response to stress, and that this enhances the survival of both KRAS-mutant and wild-type cells.



Metastasis: The fat controller

2017-01-27

Salvador Aznar Benitah and colleagues have identified a subpopulation of cells with high metastatic potential that express high levels of the fatty acid receptor CD36 in human oral carcinoma samples.



Tumour metabolism: Packed full of protein!

2017-01-27

Davidson et al. used an implantable microdevice to show that pancreatic tumours in vivo catabolize proteins in their local environment, by macropinocytosis, to derive amino acids for cell growth.



Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

2017-01-04

Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under



Cell cycle proteins as promising targets in cancer therapy

2017-01-27

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy. Intriguingly, animal models demonstrate that some of these proteins are not essential for proliferation of non-transformed cells



The recurrent architecture of tumour initiation, progression and drug sensitivity

2016-12-15

Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator (MR) proteins, the aberrant activity of which is both necessary and sufficient to maintain tumour cell state. These proteins form small,



Cancer cell motility: lessons from migration in confined spaces

2016-12-02

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through