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Preview: Nature Reviews Cancer - Issue - science feeds

Nature Reviews Cancer


Tumour evolution: Metastasis takes a different route


A new study has looked at the evolutionary origins of lymphatic and distant metastases in human colorectal cancer and found that, in most cases, cancer spread to lymph nodes is not a precursor for seeding of cancer cells to other organs.

Therapeutic resistance: Ironing it out


Since mesenchymal-like properties in cancer cells are often associated with therapy resistance, Viswanathan et al. explored vulnerabilities of these cells. They identified an enzyme of the lipid peroxidase pathway, inhibition of which caused ferroptosis in a range of cancer types.

Metastasis: Throwing oil into the flames


Both obesity and systemic inflammation promote cancer progression, although how obesity-associated inflammation affects cancer metastasis is poorly understood. Quail et al. now show that obesity induces cytokines that stimulate lung neutrophilia in mice, thereby promoting breast cancer metastasis.

Immunotherapy: Searching in the immune checkpoint black box


Reporting in Nature, the team led by Haining has identified that deletion of Ptpn2, among other genes, in tumour cells makes them more susceptible to PD1 inhibitors.

Therapy-related myeloid neoplasms: when genetics and environment collide


Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or radiation administered for a primary condition, typically a malignant disease, solid organ transplant or autoimmune disease. Survival is measured in months, not years, making t-MN one of the most aggressive and lethal cancers.

Targeting autophagy in cancer


Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been

Evolutionary biology of high-risk multiple myeloma


The outcomes for the majority of patients with myeloma have improved over recent decades, driven by treatment advances. However, there is a subset of patients considered to have high-risk disease who have not benefited. Understanding how high-risk disease evolves from more therapeutically tractable stages is

Unravelling biology and shifting paradigms in cancer with single-cell sequencing


The fundamental operative unit of a cancer is the genetically and epigenetically innovative single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated elsewhere, single cells govern the parameters that dictate all facets of the biology of cancer. Thus, single-cell analyses provide

Targeting neoantigens to augment antitumour immunity


Nature Reviews Cancer17, 209–222 (2017)In the legend of Figure 2 of this article there was an error in the formula for the objective response rate (ORR). The formula should read ORR (%) = 8 x ln(x) +