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Preview: Nature Reviews Cancer - Issue - nature.com science feeds

Nature Reviews Cancer





 



Immunotherapy: T cells get a ride

2017-05-24

Strategies that inhibit the immune checkpoint blockade (ICB) and reactivate T cells using monoclonal antibodies against programmed cell death protein 1 (PD1) and PD1 ligand 1 (PDL1) have been used to successfully treat immunogenic tumours, and recent efforts have focused on combining this approach with



The ETS family of oncogenic transcription factors in solid tumours

2017-04-28

Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory complexes and novel cis-acting mutations in ETS



Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy

2017-05-24

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. The outcome



The calcium–cancer signalling nexus

2017-04-07

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past



Genetics: Gender-specific factors in cancer susceptibility

2017-05-24

Two studies published in Nature Genetics have delved into the complex genetics of cancer susceptibility and have shown links of both timing of puberty onset and mosaic loss of chromosome Y (mLOY) to cancer risk.Previous genomic analyses have indicated various genetic factors associated



Immunotherapy: Programming T cells in situ

2017-05-24

Adoptive T cell therapy with patient-derived cells engineered ex vivo to express chimeric antigen receptors (CARs) is a promising therapeutic strategy in cancer, but producing these cells for a large number of patients is both technically challenging and cost prohibitive. Smith et al.



Tumorigenesis: Cancer as a symptom of evolution?

2017-05-05

A paper in Science by Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types.



Metastasis: The plastic state

2017-05-12

ZEB1-mediated epithelial-mesenchymal transition (EMT) and cellular plasticity promotes metastasis in pancreatic cancer.



RNA editing-dependent epitranscriptome diversity in cancer stem cells

2017-04-18

Cancer stem cells (CSCs) can regenerate all facets of a tumour as a result of their stem cell-like capacity to self-renew, survive and become dormant in protective microenvironments. CSCs evolve during tumour progression in a manner that conforms to Charles Darwin's principle of natural selection.