2016-11-23Two studies have revealed two possible mechanisms that might explain why VEGF inhibition can be rendered ineffective
2016-11-11A subset of cancer cells is dependent on a large, stable multi-protein complex called the epichaperome for survival under conditions of stress.
2016-11-23Two papers examine the influence of different stem cell characteristics on tumorigenesis in an organ-specific and age-associated manner, continuing the debate on the influence of intrinsic and extrinsic factors on cancer risk.
2016-11-23Mathias Wenes and colleagues have studied metabolic changes in tumour associated macrophages (TAMs) and found that specific alterations of mTOR regulation through regulated in development and DNA damage response 1 (REDD1) results in defective blood vessel formation and increased metastasis.
2016-11-23A paper in Nature describes a highly specific and potent small molecule inhibitor of MCL1 that has single-agent activity and good tolerability in several cancer models.
2016-11-11An analysis of pancreatic ductal adenocarcinoma genomes indicates that many of these tumours undergo polyploidization and chromothripsis, leading to rapid acquisition of genetic changes required for tumour progression.
2016-11-03Boice, Salloum, Mourcin et al. show that HVEM is an important tumour suppressor in lymphomas and that direct delivery of a soluble HVEM peptide using engineered T cells might be therapeutically beneficial.
2016-11-04Daillère et al. have identified two bacterial species that mediate systemic and tumour-infiltrating T cell responses associated with the antitumour efficacy of the chemotherapy drug cyclophosphamide.
2016-11-23Neutrophils can capture and kill pathogens by releasing DNA and associated proteolytic enzymes into the extracellular space, forming structures known as neutrophil extracellular traps (NETs). Park et al. have shown that in the absence of infection, metastatic breast cancer cells can stimulate neutrophils to
2016-11-23Metabolic and epigenetic states in cells can be linked when intermediary metabolism generates substrates for chromatin regulation. Kottakis et al. have found that synergistic liver kinase B1 (LKB1) loss and KRAS activation can promote mTOR-mediated serine biosynthesis pathway dependency during pancreatic tumorigenesis. The subsequent
2016-11-23Kohlhapp et al. found that acute influenza infection accelerates cancer-specific death of immunocompetent mice injected with B16 melanoma cells. Infection caused CD8+ T cells to move from the tumour to the site of infection, thus allowing increased tumour growth; this could be
2016-11-23Immunotherapies are not effective in all cancer patients, likely due in part to immunosuppressive networks in advanced tumours. Moynihan et al. found that combination immunotherapy consisting of four components (a tumour antigen-targeting antibody, extended half-life recombinant interleukin-2, a programmed cell death protein 1 (PD1)
2016-09-30Fundamental cancer research and the development of efficacious antineoplastic treatments both rely on experimental systems in which the relationship between malignant cells and immune cells can be studied. Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies — each with their specific advantages and difficulties
2016-11-11Nature Reviews Cancer16, 7010.1038/nrc.2016.129(2016)In the original version of this article the DOI number was incorrect. This error has been corrected in the HTML version of the article.
2016-11-11Nature Reviews Cancer16, 619–634 (2016)Reference 32 was incorrectly cited on page 626 and references 128, 129, 134 and 135 were incorrectly cited in Table 1. These have now been replaced with the correct references.
2016-10-21Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support
2016-09-30It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV
2016-09-23Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive complex 2 (PRC2), has attracted broad research attention in the past few years because of its involvement in the development and maintenance of many types of cancer and the use of specific EZH2