Subscribe: Nature Reviews Cancer - Issue - nature.com science feeds
http://www.nature.com/nrc/current_issue/rss
Added By: Feedage Forager Feedage Grade B rated
Language: English
Tags:
autophagy  cancer metastasis  cancer  cell  cells  disease  high risk  metastasis  nature  reviews cancer  single cell  single  tumour 
Rate this Feed
Rate this feedRate this feedRate this feedRate this feedRate this feed
Rate this feed 1 starRate this feed 2 starRate this feed 3 starRate this feed 4 starRate this feed 5 star

Comments (0)

Feed Details and Statistics Feed Statistics
Preview: Nature Reviews Cancer - Issue - nature.com science feeds

Nature Reviews Cancer





 



Tumour evolution: Metastasis takes a different route

2017-08-11

A new study has looked at the evolutionary origins of lymphatic and distant metastases in human colorectal cancer and found that, in most cases, cancer spread to lymph nodes is not a precursor for seeding of cancer cells to other organs.



Therapeutic resistance: Ironing it out

2017-08-11

Since mesenchymal-like properties in cancer cells are often associated with therapy resistance, Viswanathan et al. explored vulnerabilities of these cells. They identified an enzyme of the lipid peroxidase pathway, inhibition of which caused ferroptosis in a range of cancer types.



Metastasis: Throwing oil into the flames

2017-08-24

Both obesity and systemic inflammation promote cancer progression, although how obesity-associated inflammation affects cancer metastasis is poorly understood. Quail et al. now show that obesity induces cytokines that stimulate lung neutrophilia in mice, thereby promoting breast cancer metastasis.



Immunotherapy: Searching in the immune checkpoint black box

2017-08-24

Reporting in Nature, the team led by Haining has identified that deletion of Ptpn2, among other genes, in tumour cells makes them more susceptible to PD1 inhibitors.



Therapy-related myeloid neoplasms: when genetics and environment collide

2017-08-24

Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or radiation administered for a primary condition, typically a malignant disease, solid organ transplant or autoimmune disease. Survival is measured in months, not years, making t-MN one of the most aggressive and lethal cancers.



Targeting autophagy in cancer

2017-07-28

Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been



Evolutionary biology of high-risk multiple myeloma

2017-08-24

The outcomes for the majority of patients with myeloma have improved over recent decades, driven by treatment advances. However, there is a subset of patients considered to have high-risk disease who have not benefited. Understanding how high-risk disease evolves from more therapeutically tractable stages is



Unravelling biology and shifting paradigms in cancer with single-cell sequencing

2017-08-24

The fundamental operative unit of a cancer is the genetically and epigenetically innovative single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated elsewhere, single cells govern the parameters that dictate all facets of the biology of cancer. Thus, single-cell analyses provide



Targeting neoantigens to augment antitumour immunity

2017-08-24

Nature Reviews Cancer17, 209–222 (2017)In the legend of Figure 2 of this article there was an error in the formula for the objective response rate (ORR). The formula should read ORR (%) = 8 x ln(x) +