2017-01-27Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+ breast cancer are more likely to seed metastasis than those from established tumours.
2017-01-27Grabocka and Bar-Sagi have shown that cells expressing mutant KRAS upregulate SGs in response to stress, and that this enhances the survival of both KRAS-mutant and wild-type cells.
2017-01-27Salvador Aznar Benitah and colleagues have identified a subpopulation of cells with high metastatic potential that express high levels of the fatty acid receptor CD36 in human oral carcinoma samples.
2017-01-27Davidson et al. used an implantable microdevice to show that pancreatic tumours in vivo catabolize proteins in their local environment, by macropinocytosis, to derive amino acids for cell growth.
2017-01-04Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under
2017-01-27Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy. Intriguingly, animal models demonstrate that some of these proteins are not essential for proliferation of non-transformed cells
2016-12-15Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator (MR) proteins, the aberrant activity of which is both necessary and sufficient to maintain tumour cell state. These proteins form small,
2016-12-02Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through