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Preview: Nature Medicine - Issue - nature.com science feeds

Nature Medicine - Issue - nature.com science feeds



Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research



 



α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

2017-02-07

Two decades ago, α-synuclein was identified as a key player in Parkinson's disease pathogenesis. Wong and Krainc review the upstream factors and downstream cellular mechanisms associated with α-synuclein toxicity and discuss therapeutic efforts to target synucleinopathies.



The double edge of cancer immunotherapy

2017-02-07

Immune-related adverse effects are understudied and not easily treatable risks of cancer immunotherapy. Concerted research efforts to understand the mechanisms of immunotherapy-triggered responses are crucial for developing better treatments.






Correction

2017-02-07










Exhausting alloreactivity of donor-derived CAR T cells

2017-02-07

A study in mouse models of allogeneic stem cell transplantation with donor-derived CD19 chimeric antigen receptor (CAR) T cells for the treatment of relapsed B cell malignancies indicates that T cell exhaustion might have a role in preventing allogeneic reactivity of CD19 CAR T cells.



HDAC3 sets the timer on muscle fuel switching

2017-02-07

In a recent study in mice, it is shown that circadian oscillations in genomic histone deactylase 3 (HDAC3) occupancy influence fuel switching and carbon flux in muscle to regulate glucose homeostasis and exercise performance.



Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

2017-01-16

μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pain). A combination therapy of opioid receptor agonism plus peripheral-restricted MOR antagonism abrogates these side-effects while preserving opioid analgesia in rodent models of peri-operative and chronic pain.



Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

2017-01-16

Differential expression of inflammasome gene modules and inflammasome-activating metabolites correlates with interleukin-1β expression, hypertension, arterial stiffness and longevity in older individuals.



Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

2017-01-16

Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in blood, but antibody-resistant virus did emerge.



A chikungunya fever vaccine utilizing an insect-specific virus platform

2016-12-19

New vaccine approaches that safely elicit immunity are needed to protect against infectious disease. Erasmus et al. report their development of an insect-virus-based platform that they use to engineer a protective vaccine against chikungunya fever.



Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

2017-01-09

Loss of the metalloproteinase Adamts1 leads to aortic pathology in mice due to increased NOS2-dependent NO production. Decreased Adamts1 expression, associated with increased NOS2 expression, occurs in Marfan syndrome (MFS) mice and in MFS patients, and NOS2 inhibition prevents and reverses aortic pathology in MFS mice.



Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

2016-12-26

A pharmacological screen has identified the histone methyltransferase G9a as a target to reactivate imprinted genes in a mouse model of Prader–Willi Syndrome that improves growth and survival.



Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

2016-12-19

Genetic deletion of HDAC3, a circadian epigenome regulator, specifically in skeletal muscle alters amino acid metabolism, leading to increased muscle endurance but at the cost of whole-body insulin resistance.



Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

2016-12-26

Using a device implanted in KRAS-driven pancreatic tumors, authors demonstrate that cancer cells incorporate proteins in their microenvironment as a source of amino acids. This work provides a novel approach to study tumor metabolism that could be applied with therapeutic purposes.



Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity

2017-01-09

Allogeneic chimeric antigen receptor (CAR) T cells are capable of inducing graft-versus-host disease (GVHD) in recipients, yet this is not commonly seen in the clinic. Marcel van den Brink, Michel Sadelain and colleagues show that alloreactive CAR T cells have reduced effector function due to signaling through the CAR and T cell receptor, resulting in reduced GVHD, while the graft-versus-leukemia effect is maintained by non-alloreactive CAR T cells.



SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

2016-12-19

The therapeutic response of acute myeloid leukemia to the nucleoside analog Ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the active metabolite Ara-CTP.



Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

2017-01-09

The therapeutic response of acute myelogenous leukemia to the nucleoside analog ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the activemetabolite ara-CTP.