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Preview: Nature Medicine - Issue - science feeds

Nature Medicine - Issue - science feeds

Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research


Reducing the silence


The suicide rate in the US is increasing, whereas funding for research into suicide prevention has decreased. It will take more investment to truly understand the mechanisms of action underlying the causes of this global killer and to design new treatments for those causes. But efforts must come from all segments of society.

Where are the data?


Here, we announce two policy changes across Nature journals: data-availability statements in all published papers and official Worldwide Protein Data Bank (wwPDB) validation reports for peer review.

A broader spectrum of tuberculosis


Two new studies show that high-resolution imaging can detect active tuberculosis (TB) in people otherwise diagnosed as healthy. Individuals with these signs of active infection with Mycobacterium tuberculosis (Mtb) were at an increased risk of developing clinical TB.

Blocking fatty acid synthesis reduces lung tumor growth in mice


Tumors often overexpress enzymes that synthesize fatty acids, but the requirement for fatty acid synthesis in tumor growth is unclear. A new fatty acid–synthesis inhibitor blunts lung tumor growth in mice, which implicates this process as a targetable liability.

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography


By using combined positron emission and computed tomography (PET–CT), Esmail et al. show that some patients with latent tuberculosis have signs of subclinical, active disease in the lungs and a greater likelihood of progression, suggesting a spectrum of disease rather than discrete latent and active disease states.

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure


Stephanus Malherbe and colleagues conducted positron emission tomography–computerized tomography lung scans of patients before and after tuberculosis therapy and report that even in cured, culture-negative patients the majority show lung lesions after 6 months of therapy, suggesting possible persistence of Mycobacterium tuberculosis infection.

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen


A high-throughput screen of preclinical, investigational and FDA-approved drugs identifies compounds that possess antiviral and neuroprotective effects against Zika virus infection in human neural progenitor cells and astrocytes.

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models


An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination with chemotherapy in mouse models.

An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice


Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models.

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy


The lncRNA Chaer controls hypertrophic heart growth by binding to and interfering with the function of the epigenetic regulator PRC2.

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation


RNA editing by the adenosine deaminase ADAR1 controls cathepsin S expression in endothelial cells, a mechanism that is implicated in determining cathepsin S levels in patients with atherosclerotic vascular diseases.

Purinergic receptors in the carotid body as a new drug target for controlling hypertension


A small-molecule antagonist of the P2X3 receptor reduces blood pressure in hypertensive rats via its action on the carotid body, pointing to a new drug target for treating hypertension.

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats


A novel stainless-steel pin has been engineered with a pure magnesium core that promotes improved fracture healing in rats by inducing local production of a key neuropeptide for osteogenesis.

Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect


Long-term use of serotonin-reuptake inhibitors causes bone loss by acting centrally to counteract a peripheral, beneficial effect on bone.

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma


The ubiquitin-specific protease HAUSP deubiquitinates and stabilizes N-Myc, and small-molecule inhibitors of HAUSP suppress the growth of MYCN-amplified human neuroblastoma cell lines implanted in mice.

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation


Differences in the composition of the gut microbiota of infants associate with relative risk of atopy in childhood, and metabolites linked with these distinct microbial states alter T cell differentiation ex vivo.