Subscribe: Nature Medicine - Issue - nature.com science feeds
http://www.nature.com/nm/current_issue/rss
Added By: Feedage Forager Feedage Grade B rated
Language: English
Tags:
bone marrow  bone  cell  cells  depression  disease  expression  kidney disease  leukemia  marrow  mice  myeloid  patients  stem cell  stem 
Rate this Feed
Rate this feedRate this feedRate this feedRate this feedRate this feed
Rate this feed 1 starRate this feed 2 starRate this feed 3 starRate this feed 4 starRate this feed 5 star

Comments (0)

Feed Details and Statistics Feed Statistics
Preview: Nature Medicine - Issue - nature.com science feeds

Nature Medicine - Issue - nature.com science feeds



Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research



 



Safeguarding science

2017-01-06

Changing political and funding landscapes in the US create an uncertain environment for biomedical research. The research community must insist that scientific policy follow from science, not political partisanship.












Correction

2017-01-06




A microbial protein that alleviates metabolic syndrome

2017-01-06

A recent study shows that pasteurization of Akkermansia muciniphila enhances the bacterium's ability to reduce fat mass and metabolic syndrome in mice with diet-induced obesity, and that Amuc_1100*, a thermostable outer-membrane protein of A. muciniphila, can reproduce these beneficial effects.



A bone marrow factor contributes to kidney disease

2017-01-06

Soluble urokinase plasminogen activator receptor (suPAR) is a circulating biomarker of inflammation. A recent study identifies immature myeloid cells in the bone marrow as a major cellular source of suPAR that contributes to kidney disease.



Starving leukemia to induce differentiation

2017-01-06

A new study shows that fasting induces the differentiation and elimination of some types of leukemia in mice, which implicates fasting or its mimetics as a novel strategy for the treatment of this disease.



Imaging biomarkers and biotypes for depression

2017-01-06

A new study identifies four distinct 'biotypes' of depression on the basis of fMRI resting-state functional connectivity in a diverse sample of more than 1,000 individuals. The biotypes are diagnostic of depression and predict treatment response.



T memory stem cells in health and disease

2017-01-06

Gattinoni and colleagues discuss the emerging roles of this subset of long-lived memory T lymphocytes, and highlight ways in which these cells might be exploited to achieve therapeutic aims.



Resting-state connectivity biomarkers define neurophysiological subtypes of depression

2016-12-05

Using functional MRI in a large multisite sample of more that 1,000 patients, four distinct neurophysiological biotypes of depression are defined. These biotypes are used to develop diagnostic classifiers that distinguish patients with depression from controls in separate multisite validation and replication cohorts, and can predict patient responsiveness to therapy.



Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion

2016-11-28

The thalamus-enriched microRNA miR-338-3p is depleted in mouse models of 22q11.2 deletion syndrome and in humans with schizophrenia, leading to a late-onset dysfunction of auditory thalamocortical synaptic transmission, behavioral abnormalities and altered sensitivity to antipsychotics.



Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

2016-11-21

Organoids formed by combining pluripotent-stem-cell-derived human neural crest cells with pluripotent-stem-cell-derived intestinal tissue show functional interstitial cells of Cajal and undergo waves of contraction; these tissues reveal insights into the molecular defects characterizing Hirschsprung's disease.



Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

2016-11-21

A genome-wide CRISPR screen reveals that FZD5, but none of the other nine Frizzled receptors encoded in the human genome, is a therapeutic vulnerability of pancreatic and colorectal tumors bearing RNF43 mutations.



Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

2016-12-12

Proteasomal degradation of EZH2 in AML patients in response to therapy triggers the expression of stem cell markers and has been identified as an epigenetic pathway leading to acquired drug resistance. Treatments aimed to restore EZH2 expression in relapsed AML patients have shown clinical efficacy and constitute a viable approach to re-sensitize tumors to chemotherapy.



Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

2016-12-12

In leukemic mice, fasting reduces the development of acute lymphoblastic leukemia, but not acute myeloid leukemia, via upregulation of leptin receptor expression and signaling in the leukemic cells.



Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms

2016-12-05

The Wnt pathway inhibitor Dkk1, which is produced by bone marrow osteolineage cells, promotes hematopoietic recovery after radiation injury by both direct effects on hematopoietic cells and indirect effects on bone marrow endothelial cells.



Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease

2016-12-12

Soluble uPAR is known to contribute to certain types of chronic kidney disease, and myeloid cells from the bone marrow have now been shown to be a key source of this factor.



A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

2016-11-28

Akkermansia muciniphila, a member of the gut microbiome, has been shown to improve metabolism in mice. Here it is reported that its pasteurization further improves this effect, and that one of its membrane proteins by itself has a similar benefit.



Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer

2016-11-21

Copy-number alterations detected in circulating tumor cells at time of diagnosis predict chemosensitive versus chemorefractory responses; however, CTCs obtained after subsequent relapse bear a chemosensitive copy-number alteration profile, which suggests that different mechanisms drive initial and acquired chemoresistance.



Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

2016-11-21

By reducing the availability of extracellular L-cyst(e)ine, an engineered enzyme inhibits glutathione production and cripples antioxidant defenses of tumors in a variety of mouse models.



Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor

2016-12-05

B cells protect against inflammation-associated preterm labor via IL-33-induced PIBF1 expression in mice, which suggests a therapy for this condition in humans.