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Nature Cell Biology



Publishes papers of the highest quality from all areas of cell biology.



 



Journal metrics: what's in a number?

2017-07-28

Metrics of research assessment should be applied with judgment and clarity to avoid undermining scientific efforts.



Organelle biogenesis in the endoplasmic reticulum

2017-07-17

In this Review, Prinz and co-authors discuss the role of the endoplasmic reticulum (ER) in the de novo generation of peroxisomes, lipid droplets and omegasomes, and how this requires subdomains with specific protein and lipid compositions.



CTCF fences make good neighbours

2017-07-28

CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.



Origin and regulation of a lung repair kit

2017-07-28

The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value.



The skinny on obesity and cancer

2017-07-28

Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss.



A key HDAC6 dependency of ARID1A-mutated ovarian cancer

2017-07-28

Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.



Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

2017-07-17

Zhou et al. demonstrate that bone marrow adipocytes, but not intraperitoneal adipocytes, express high levels of stem cell factor (SCF), which is essential for the regeneration of haematopoietic stem cells and haematopoiesis after irradiation.



Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

2017-07-24

Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5+ basal-like cells in the lung. On HIF1α loss, epithelial progenitors directly differentiate into alveolar type II cells and promote functional regeneration.



Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

2017-07-17

Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation.



Endothelial Notch signalling limits angiogenesis via control of artery formation

2017-07-17

Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation.



Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation

2017-07-17

Lengefeld et al. reveal how yeast cells distinguish between newly synthesized and pre-existing spindle pole bodies to enable their asymmetric segregation, through a mechanism involving Swe1, Kin3 and NuA4.



Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

2017-07-24

Hanssen et al. show that CTCF–cohesin binding sites at the α-globin gene cluster function as boundaries to restrict the interaction of enhancers with the flanking chromatin, thus preventing abnormal gene expression.



ARID1A-mutated ovarian cancers depend on HDAC6 activity

2017-07-24

Bitler et al. show that HDAC6 activity is essential for the survival of ovarian cancer cells carrying loss-of-function ARID1A mutation, thus representing a promising therapeutic target.



Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

2017-07-24

Joyce and colleagues report that obesity promotes lung neutrophilia in mice, which in the presence of a primary breast tumour fosters metastasis to the lung in a manner dependent on GM-CSF and IL5.



Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization

2017-07-24

Studying polarity establishment in C. elegans zygotes, Wang et al. find, by imaging GFP-tagged proteins, that clusters of the PAR-3 polarity protein assemble in response to membrane tension created by actomyosin contractility.



Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

2017-07-28

Lin et al. find that stress-induced p38 MAPK activation leads to cytoplasmic relocation of the Hippo pathway nuclear transcription factor TEAD. TEAD relocation causes inhibition of YAP activity and suppresses YAP-driven cancer cell growth.