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cell  cells  glutamine  independently mtorc  integrin  lysosome  microtubule  mtorc  promotes  repair  signalling  tumour core  tumour  tumours 
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Preview: Nature Cell Biology - Issue - science feeds

Nature Cell Biology - Issue - science feeds

Articles and research papers on cell division, cell structure, animal and plant cell biology and cell cycles.


Turn up the lysosome


Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.

Regional tumour glutamine supply affects chromatin and cell identity


Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy


Kodo et al. show that patient-specific iPSC-derived cardiomyocytes recapitulate the proliferative defects associated with the disease, which are a result of TBX20 mutations and abnormal TGF-β signalling.

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling


Using a chimaeric integrin α5 (where the tail is replaced by that of α2), Yun et al. show that in endothelial cells, integrin α5 interacts with the cAMP-specific phosphodiesterase PDE4D5 to reduce cAMP levels and inflammation both in vitro and in vivo.

Self-repair promotes microtubule rescue


Microtubules can self-repair in vitro in response to stress. Théry and colleagues now show that such repair can occur in cells, as free tubulin dimers can be incorporated into a damaged microtubule lattice to promote rescue events.

Protein kinase C controls lysosome biogenesis independently of mTORC1


Using a chemical screening approach, Yang and colleagues identify PKC as a regulator of lysosome biogenesis, which controls the subcellular localization of TFEB and ZKSCAN3 through parallel signalling pathways and independently of mTORC1.

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow


Johnson et al. report that loss of leukaemia inhibitory factor receptor (LIFR) signalling reduces the expression of genes associated with dormancy in metastatic breast cancer cells, and promotes bone marrow colonization and osteoclastogenesis.

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation


Pan et al.  find that regional glutamine deficiency in melanoma tumours induces tumour cell dedifferentiation and confers therapeutic resistance through histone methylation changes.

EB1 interacts with outwardly curved and straight regions of the microtubule lattice


Guesdon et al.  characterize the microtubule-end-binding region of EB1 using cryo-electron tomography, providing insights into the mechanism of this interaction and the architectural changes in the GTP-cap region during microtubule growth.