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cadherin  cell  cells  chromosome  end joining  end  homologous end  joining  repair  signalling  stem cell  stem cells  stem  vinculin 
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Preview: Nature Cell Biology - Issue - nature.com science feeds

Nature Cell Biology - Issue - nature.com science feeds



Articles and research papers on cell division, cell structure, animal and plant cell biology and cell cycles.



 



The control of DNA repair by the cell cycle

2016-12-23

In this Review, Hustedt and Durocher discuss recent advances in our understanding of how different repair pathways, in particular double-strand break repair, are regulated across the cell cycle to ensure faithful segregation of the genome.



Haematopoietic stem cells show their true colours

2016-12-23

Delineating the behaviour of haematopoietic stem cells (HSCs) in vivo has thus far proven challenging. Two studies in zebrafish and mouse models now track HSCs in vivo using fate mapping with multicolour approaches to provide further insights into clonal events that regulate blood development, HSC function and differentiation during homeostasis and stress conditions.



Y chromothripsis?

2016-12-23

Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.



Resolving the cadherin–F-actin connection

2016-12-23

Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.



Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development

2016-11-21

Henninger et al. analyse the early clonal events that underlie haematopoiesis and establish the number of stem cell clones that arise from the ventral dorsal aorta to maintain lifelong blood production.



Nanoscale architecture of cadherin-based cell adhesions

2016-12-19

Bertocchi and colleagues describe the organization of cadherin-based adhesions using super-resolution microscopy. They find that α-catenin is important for vinculin localization and observe a conformational change in vinculin following its activation.



A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis

2016-12-05

Lin and colleagues report that hypoxia induces TRAF6-dependent mono-ubiquitylation of histone H2AX, which promotes binding and stabilization of HIF1α. Activated HIF1α signalling in turn promotes tumorigenesis and metastasis.



Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis

2016-12-19

Resnik-Docampo et al. demonstrate that depletion of the tricellular junction protein Gliotactin in young flies leads to hallmarks of ageing, including an increase in intestinal stem cell proliferation and a block in terminal differentiation.



LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency

2016-12-19

Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability and effects of LIN28 on direct mRNA targets through its phosphorylation by ERK.



Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

2016-12-05

Ly et al. establish a method to selectively inactivate the centromere of the Y chromosome to follow chromosome shattering and micronuclei formation through several cell cycles, and suggest re-ligation of chromosome fragments is dependent on non-homologous end joining.