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Preview: Nature Cell Biology - Issue - nature.com science feeds

Nature Cell Biology



Publishes papers of the highest quality from all areas of cell biology.



 



Principles of refereeing

2017-08-31

Peer review is a key element of scientific publishing. Here we discuss what constitutes the ideal referee report.



Enhancing brown fat with NFIA

2017-08-31

Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.



DNA sensing in senescence

2017-08-31

Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.



Lab-grown mini-brains upgraded

2017-08-31

Three-dimensional brain organoid models have come into the spotlight as in vitro tools to recapitulate complex features of the brain. Four recent papers now leverage current technologies to generate new flavours of brain organoids and address aspects of brain biology which, to date, have been challenging to explore.



A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

2017-08-31

Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.



A caspase-independent way to kill cancer cells

2017-08-31

Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.



Lactate dehydrogenase activity drives hair follicle stem cell activation

2017-08-14

Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.



Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

2017-08-14

Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.



ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

2017-08-28

Skamagki et al. show that pluripotency factor ZSCAN10 is poorly expressed in iPSCs derived from aged donors, and its addition during reprogramming restores the DNA damage response and genomic stability through normalization of ROS–glutathione levels.



An apical MRCK-driven morphogenetic pathway controls epithelial polarity

2017-08-21

Zihni et al. discover a role for Cdc42–MRCK signalling in establishing contractility at the apical pole, which in turn controls epithelial polarity in mammalian cells and Drosophila photoreceptors.



Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

2017-07-31

Glück et al. find that the DNA-sensing component cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments produced in senescent cells leading to STING-mediated production of SASPs, which promotes paracrine senescence.



SMC complexes differentially compact mitotic chromosomes according to genomic context

2017-08-21

Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.



NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

2017-08-14

Hiraike et al. identify nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat. NFIA activates cell-type-specific enhancers prior to differentiation and facilitates PPARγ binding to regulate the brown fat gene program.



Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

2017-08-21

Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.



A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression

2017-08-21

Grelet et al. find that hnRNP E1 release from PNUTS pre-RNA in response to TGFβ generates a lncRNA that acts as competitive sponge for miR-205, promoting epithelial–mesenchymal transition in cancer.



Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

2017-08-28

Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects.