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Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.


The problem with neoantigen prediction


Personalized immunotherapy is all the rage, but neoantigen discovery and validation remains a daunting problem.



Drug pipeline: 4Q16


Fresh from the biotech pipeline—2016


Despite last year's sharp decline in approvals, registrations of two RNA drugs offer a window into the current state and possible future of drug development. Looking forward, the sector seeks greater clarity on the new presidential administration's priorities and the impact of new healthcare legislation. Chris Morrison reports.

So you want to be a student entrepreneur?


Practical tips for graduate students with an aspiration to start a life science venture.

Situating brain regions among patent rights and moral risks


What is the ethical value of awarding patent rights that implicate regions of the brain?

Core promoters across the genome


Promoter strength is measured genome-wide with two high-throughput reporter assays.

Exploring protein sequence–function landscapes


The effects of sequence variation on function are elucidated by a study of protein evolution.

Research Highlights


Mutation effects predicted from sequence co-variation


The global effects of epistasis on protein and RNA function are revealed by an unsupervised model of amino acid co-conservation in evolutionary sequence variation.

Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution


STAP-seq quantifies the ability of genomic DNA sequences to convert enhancer activities into transcription initiation events.

Genome-wide mapping of autonomous promoter activity in human cells


The intrinsic strength of promoter sequences in driving transcription is measured across the human genome.

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells


Cortical neurons are rapidly derived from human pluripotent stem cells using a cocktail of small molecules.

Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry


Mass-cytometry analysis reveals how signaling networks respond to changes in the abundance of their nodes.

Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism


Cytosolic redox metabolism is rewired to improve lipid yield and productivity in the industrial yeast Yarrowia lipolytica