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Preview: Nature Biotechnology

Nature Biotechnology



Covering the science and business of biotechnology.



 



CRISPR catch-up

2017-05-09

The hegemony of the CRISPR system as a gene-editing therapy is not as assured as its use as a tool in basic research.
























Drug pipeline: 1Q17

2017-05-09




Living in a microbial world

2017-05-09

Our personal ecosystem of microbes is shed on everything we touch and everyplace we go. Charles Schmidt reports on efforts to harness this information to improve human health and activity.















Biotech's wellspring—a survey of the health of the private sector in 2016

2017-05-09

Investment is skewing early as venture capitalists grapple with a volatile political environment, a hot stock market and a flagging IPO outlook.



Who reads patents?

2017-05-09

Biotechnology and chemistry researchers look to the patent literature as a source of technical information more than researchers in other fields, and few researchers are deterred from reading patents by concerns about enhanced legal liability.






Reprogramming the diseased brain

2017-05-09

Direct conversion of astrocytes to dopamine neurons in vivo offers fresh optimism for the development of improved Parkinson's disease therapies.



Base editing on the rise

2017-05-09

Research on base editing leads to new enzymes, genome-wide specificity measurements, and edited plants and animals.



Research Highlights

2017-05-09







Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

2017-02-13

Gene editing in the mouse brain is achieved by injection of Cas9 ribonucleoprotein complexes.



Highly efficient RNA-guided base editing in mouse embryos

2017-02-27

Mice with targeted point mutations are generated efficiently using Cas9–cytidine deaminase fusions.



Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

2017-02-27

Single DNA base pairs are edited in wheat, rice and maize using a Cas9 nickase fusion protein.



Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

2017-03-27

Targeted editing of single base pairs is achieved in monocot rice and dicot tomato using Target-AID (Cas9 activation-induced cytidine deaminase fusion).



Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

2017-04-10

In vivo reprogramming of astrocytes to dopamine neurons improves motor behavior in a mouse model of Parkinson's disease.



Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

2017-03-27

Genetic circuits that are reliable, robust, and scalable are built without the need for optimization using a recombinase-based system.



Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

2017-03-20

An improved strategy for large-scale combinatorial CRISPR screening enables the identification of synergistic drug targets for cancer.



Genome-wide target specificities of CRISPR RNA-guided programmable deaminases

2017-04-10

Base editors composed of Cas9 fused to a deaminase show high specificity in genome-wide analyses.





















People

2017-05-09