Subscribe: Nature Biotechnology
Added By: Feedage Forager Feedage Grade B rated
Language: English
base editing  base  cas  crispr  deaminase  dopamine neurons  editing mouse  editing  genome wide  genome  mouse  parkinson disease 
Rate this Feed
Rate this feedRate this feedRate this feedRate this feedRate this feed
Rate this feed 1 starRate this feed 2 starRate this feed 3 starRate this feed 4 starRate this feed 5 star

Comments (0)

Feed Details and Statistics Feed Statistics
Preview: Nature Biotechnology

Nature Biotechnology

Covering the science and business of biotechnology.


CRISPR catch-up


The hegemony of the CRISPR system as a gene-editing therapy is not as assured as its use as a tool in basic research.

Drug pipeline: 1Q17


Living in a microbial world


Our personal ecosystem of microbes is shed on everything we touch and everyplace we go. Charles Schmidt reports on efforts to harness this information to improve human health and activity.

Biotech's wellspring—a survey of the health of the private sector in 2016


Investment is skewing early as venture capitalists grapple with a volatile political environment, a hot stock market and a flagging IPO outlook.

Who reads patents?


Biotechnology and chemistry researchers look to the patent literature as a source of technical information more than researchers in other fields, and few researchers are deterred from reading patents by concerns about enhanced legal liability.

Reprogramming the diseased brain


Direct conversion of astrocytes to dopamine neurons in vivo offers fresh optimism for the development of improved Parkinson's disease therapies.

Base editing on the rise


Research on base editing leads to new enzymes, genome-wide specificity measurements, and edited plants and animals.

Research Highlights


Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes


Gene editing in the mouse brain is achieved by injection of Cas9 ribonucleoprotein complexes.

Highly efficient RNA-guided base editing in mouse embryos


Mice with targeted point mutations are generated efficiently using Cas9–cytidine deaminase fusions.

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion


Single DNA base pairs are edited in wheat, rice and maize using a Cas9 nickase fusion protein.

Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion


Targeted editing of single base pairs is achieved in monocot rice and dicot tomato using Target-AID (Cas9 activation-induced cytidine deaminase fusion).

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model


In vivo reprogramming of astrocytes to dopamine neurons improves motor behavior in a mouse model of Parkinson's disease.

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells


Genetic circuits that are reliable, robust, and scalable are built without the need for optimization using a recombinase-based system.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions


An improved strategy for large-scale combinatorial CRISPR screening enables the identification of synergistic drug targets for cancer.

Genome-wide target specificities of CRISPR RNA-guided programmable deaminases


Base editors composed of Cas9 fused to a deaminase show high specificity in genome-wide analyses.