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Preview: Nature Biotechnology

Nature Biotechnology - Issue - science feeds

Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.


In this issue


The commercial tipping point


RNA-based therapeutics are poised to become successful commercial products, but wide adoption across the biopharmaceutical industry will likely take a few more years.

The 'anti-hype' vaccine


After years under the radar, RNA vaccines are finally emerging as immunotherapies to combat pandemics and cancer. But as Laura DeFrancesco reports, clinical validation remains elusive.

Worth the RISC?


The long, tortuous race to market a therapeutic based on RNA interference (RNAi) may be nearing its end. Ken Garber reports.

Evidence of insufficient quality of reporting in patent landscapes in the life sciences


Despite the importance of patent landscape analyses in the commercialization process for life science and healthcare technologies, the quality of reporting for patent landscapes published in academic journals is inadequate.

Hearing in the mouse of Usher


Hearing and balance are rescued by a synthetic virus that delivers a transgene to the inner ear of neonatal mice.

Fleeting factors, turning back time


Old cells and tissues become young again after a short dose of reprogramming factors.

Research Highlights


Overcoming cellular barriers for RNA therapeutics


Recent progress in delivering RNA therapeutics to the inside of cells might lead to more success in clinical applications.

The chemical evolution of oligonucleotide therapies of clinical utility


Refinements in the chemistries employed in oligonucleotide therapeutics have galvanized clinical progress. The complex interplay between chemical modifications and integration into sequence architecture is discussed in the context of antisense and small-interfering RNA drugs.

Oligonucleotide therapies for disorders of the nervous system


Brain-targeted oligonucleotide-drugs are poised to treat multiple human central nervous system disorders with an emphasis on rare/orphan conditions.

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c


Gene therapy in the inner ear achieves unprecedented recovery of hearing and balance behavior in Usher syndrome mice.

Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit


An inducer-free quorum-sensing circuit is applied to control endogenous bacterial gene expression and improve yields of a range of products.

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear


Efficient gene transfer to the mouse inner ear is achieved with a synthetic adeno-associated viral vector.

International mentoring as a new educational approach to alleviate brain drain, empower young talent, and internationalize higher education


A novel program shows that young professionals working abroad can be instrumental in their home country's development.