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Preview: Nature Biotechnology

Nature Biotechnology

Covering the science and business of biotechnology.


Time for the data to speak


Retraction of a study claiming gene editing via an Argonaute enzyme illustrates the importance of post-publication peer review in the age of 24/7 media.

Drug pipeline 2Q17


Engineering the animal out of animal products


Amber Dance reports on a new wave of domestication—turning cells, rather than animals, into food.

Big data opens a window onto wellness


Longitudinal multi-omics data, clinical tests and biomarker analyses across a large cohort lay the groundwork for understanding the transition from wellness to disease.

Pluripotent stem cells that evade the immune radar


Human pluripotent stem cells are cloaked to evade immune rejection.

Research Highlights


Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea


Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.

Characterization of noncoding regulatory DNA in the human genome


Genome-wide mapping of regulatory elements will improve our understanding of how genetic variation in the noncoding genome affects disease phenotypes.

A wellness study of 108 individuals using personal, dense, dynamic data clouds


Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.

Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy


Expansion microscopy, a technique for super-resolution imaging, is extended to clinical human tissue samples that are formalin fixed, paraffin embedded, stained and/or fresh frozen.

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells


Expression of the minimally polymorphic HLA-E molecule prevents NK-cell-mediated rejection of cells lacking expression of HLA-A, B and C.

Long time-lapse nanoscopy with spontaneously blinking membrane probes


Super-resolution imaging of the dynamics of organelle structures in live cells is facilitated by blinking, far-red dyes.

Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS


Detection of post-translational modifications by mass spectrometry is enhanced with an analytic method for data-independent acquisition proteomics.

Engineered Cpf1 variants with altered PAM specificities


The targeting range of the CRISPR endonuclease Cpf1 is increased three-fold by molecular engineering.

Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly


Rapid cloning of genes from any crop plant species (or cultivar) whose chromosomes can be flow sorted is enabled by a combination of short-read sequencing and proximity ligation.