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Nature Biotechnology - Issue - science feeds

Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.


A futile cycle in cell therapy


Should a cell therapy for heart disease with scant evidence of efficacy continue to be tested in humans?

Nature Biotechnology's academic spinouts of 2016


Our annual survey highlights several academic startups developing immunotherapies as well as ventures focusing on microbiomes, proteostasis, integrin biology, nucleic acid delivery and subcellular imaging.

Differing diagnoses for European and US patents


Medical diagnostic patent applications in the United States and Europe face diverging fates following the Supreme Court's decision in Mayo.

mHealth advances clinical research, bit by bit


Monitoring the symptoms of a large cohort of asthma patients is made possible by a smartphone app created using Apple ResearchKit.

Single-minded CRISPR screening


Transcriptome-wide effects of gene knockouts are screened at the single-cell level by combining high-throughput, single-cell RNA-seq with lentiviral CRISPR libraries.

Research Highlights


Reproducibility of computational workflows is automated using continuous analysis


The application of continuous integration, an approach common in software development, enables the automatic reproduction of computational analyses.

GuideScan software for improved single and paired CRISPR guide RNA design


A tool for genome-wide design of CRISPR guide RNAs reduces off-target effects and facilitates targeting of the non-coding genome.

Prediction of potent shRNAs with a sequential classification algorithm


The most effective shRNAs to silence a gene are calculated by a machine learning algorithm.

The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit


Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies.

A FRET sensor enables quantitative measurements of membrane charges in live cells


The electrostatic potential of the plasma membrane of live mammalian cells is measured with a FRET-based sensor.

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions


Genome editing of single bases is made more versatile and accurate with new fusions of mutated Cas9 and cytidine deaminase domains.

Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters


An antinutritional compound in Brassica seed meal is reduced by knocking out genes encoding transporter proteins.

Continuous positive compensation trends indicate a healthy private life sciences sector


Non-founder total target cash compensation in 2016 increased 4.2% year-over-year at private life sciences companies and 6% at private technology companies.