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Nature Biotechnology - Issue - science feeds

Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.


Concerns over Cures


Provisions in the 21st Century Cures Act related to leadership at the US National Institutes of Health (NIH) may spell trouble ahead.

Where are the data?


Nature Biotechnology now requires data availability statements to be supplied with research papers.

After Theranos


The implosion of blood diagnostics developer Theranos has raised the question: What is feasibly detectible in a drop of blood? Emily Waltz reports.

The rise of the ethical license


The Broad Institute's recent licensing of its gene editing patent portfolio demonstrates how licenses can be used to restrict controversial applications of emerging technologies while society deliberates their implications.

An optical probe of synaptic plasticity


An endogenous protein in the mouse brain is inactivated using a light-sensitive antibody construct.

Mining ancient proteins for next-generation drugs


Predicting the evolutionary ancestors of a protein drug provides a strategy for optimizing its pharmaceutical properties.

Research Highlights


Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array


Multiplexed genome editing is simplified by harnessing the ability of Cpf1 to process its own pre-crRNA.

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction


The pharmaceutical properties of coagulation factor VIII are improved by reconstructing the protein's ancestral sequence.

Optical inactivation of synaptic AMPA receptors erases fear memory


Development of an optical method to inactivate synaptic receptors in mice with temporal precision will enable a better understanding of their roles in cognition.

Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering


An approach called CREATE enables multiplex genome engineering, protein engineering and mapping of mutations in bacterial and yeast cells.

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker


Cardiomyocytes derived from human stem cells act as a biological pacemaker in the rat heart.

Influence of donor age on induced pluripotent stem cells


Induced pluripotent stem cells generated from older individuals have higher levels of epigenetic and genetic abnormalities.

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter


Urea transporter can be used as a sensitive, contrast agent-free gene reporter for magnetic resonance imaging in cells and whole animals.

Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota


A large set of microbial metabolic models (AGORA) could be applied to better understand the functions of the human gut microbiome.

The impact of postdoctoral training on early careers in biomedicine


While postdocs are necessary for entry into tenure-track jobs, they do not enhance salaries in other job sectors over time.