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Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.



 



Concerns over Cures

2017-01-10

Provisions in the 21st Century Cures Act related to leadership at the US National Institutes of Health (NIH) may spell trouble ahead.



Where are the data?

2017-01-10

Nature Biotechnology now requires data availability statements to be supplied with research papers.

































After Theranos

2017-01-10

The implosion of blood diagnostics developer Theranos has raised the question: What is feasibly detectible in a drop of blood? Emily Waltz reports.















The rise of the ethical license

2017-01-10

The Broad Institute's recent licensing of its gene editing patent portfolio demonstrates how licenses can be used to restrict controversial applications of emerging technologies while society deliberates their implications.






An optical probe of synaptic plasticity

2017-01-10

An endogenous protein in the mouse brain is inactivated using a light-sensitive antibody construct.



Mining ancient proteins for next-generation drugs

2017-01-10

Predicting the evolutionary ancestors of a protein drug provides a strategy for optimizing its pharmaceutical properties.



Research Highlights

2017-01-10







Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

2016-12-05

Multiplexed genome editing is simplified by harnessing the ability of Cpf1 to process its own pre-crRNA.



Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

2016-09-26

The pharmaceutical properties of coagulation factor VIII are improved by reconstructing the protein's ancestral sequence.



Optical inactivation of synaptic AMPA receptors erases fear memory

2016-12-05

Development of an optical method to inactivate synaptic receptors in mice with temporal precision will enable a better understanding of their roles in cognition.



Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

2016-12-12

An approach called CREATE enables multiplex genome engineering, protein engineering and mapping of mutations in bacterial and yeast cells.



Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

2016-12-12

Cardiomyocytes derived from human stem cells act as a biological pacemaker in the rat heart.



Influence of donor age on induced pluripotent stem cells

2016-12-12

Induced pluripotent stem cells generated from older individuals have higher levels of epigenetic and genetic abnormalities.



MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter

2016-12-05

Urea transporter can be used as a sensitive, contrast agent-free gene reporter for magnetic resonance imaging in cells and whole animals.



Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota

2016-11-28

A large set of microbial metabolic models (AGORA) could be applied to better understand the functions of the human gut microbiome.



The impact of postdoctoral training on early careers in biomedicine

2017-01-10

While postdocs are necessary for entry into tenure-track jobs, they do not enhance salaries in other job sectors over time.



People

2017-01-10