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Nature Biotechnology

Covering the science and business of biotechnology.


Wanted: biotech for an aging population


Digital medicine's extraordinary ability to communicate with patients, especially in under-served communities, could help reorient the biotech industry to better address aging and its associated diseases.

An emerging model for life sciences commercialization


There are challenges in transplanting the US–European technology transfer model to emerging economies.

Public biotech in 2016—the numbers


The anticipated decline in the biotech industry's ability to raise capital from public investors and an accompanying slump in biotech markets materialized in 2016, but all is not gloom and doom.

CRISPR–Cas9 claim sets and the potential to stifle innovation


Extremely broad claims surrounding Cas9 nucleases have the potential to stifle innovation in the field of genome editing.

Single-cell genomics for the masses


Microbial communities are rapidly sequenced at the single-cell level using droplet microfluidics.

Algal oil productivity gets a fat bonus


Partitioning of carbon to lipids is engineered to improve oil accumulation in an industrial alga.

Research Highlights


Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding


More than 50,000 single-cell genomes are sequenced in a single run using droplet barcoding.

Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator


Lipid production in the oleaginous microalga Nannocholoropsis gaditana is doubled by decreasing the expression of a transcriptional regulator identified through a CRISPR–Cas9 reverse-genetics approach.

Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation


An engineered commensal E. coli strain can function as a living diagnostic for a marker of inflammation in the murine gut for 200 days.

Guided self-organization and cortical plate formation in human brain organoids


Engineering human brain organoids with floating scaffolds enhances the maturity and reproducibility of cortical tissue structure.

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site


A method to target trimeric membrane proteins by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin.

Digital-to-biological converter for on-demand production of biologics


Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing.

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life


Metagenomic and microbial sequence data are made easier to interpret with the addition of 1,003 genomes to the Genomic Encyclopedia of Bacteria and Archaea.

Unlocking Big Data for better health


As the volume of biomedical data being created grows, so does the need for data analytics training for life science researchers.