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Nature Biotechnology - Issue - science feeds

Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.


Evolving fixes for drug pricing


Despite an increasingly strident outcry against drug prices in the United States, manufacturers likely face an evolution in the reimbursement landscape, rather than a revolution.

Closing the deal


A checklist for negotiating robust licensing agreements.

America's drug problem


Chasing treatments and gouging patients in a bloated, capitalist healthcare system.

An update on obtaining and enforcing therapeutic antibody patent claims


Therapeutic antibody patent owners face continuing challenges trying to obtain broad patents and enforce them in the United States and Europe.

Let there be light—at the right place


A light-sheet microscope that automatically corrects optical aberrations enables quantitative imaging of deep tissue.

Are human oocytes from stem cells next?


The generation of oocytes in a dish from mouse pluripotent cells may be difficult to replicate with human cells.

Research Highlights


Imagining the future of bioimage analysis


Modern biological research increasingly relies on image data as a primary source of information in unraveling the cellular and molecular mechanisms of life. The quantity and complexity of the data generated by state-of-the-art microscopes preclude visual or manual analysis and require advanced computational methods to fully explore the wealth of information. In addition to making bioimage analysis more efficient, objective, and reproducible, the use of computers improves the accuracy and sensitivity of the analyses and helps to reveal subtleties that may be unnoticeable to the human eye. Many methods and software tools have already been developed to this end, but there is still a long way to go before biologists can blindly trust automated measurements. Here, we summarize the current state of the art in bioimage analysis and provide a perspective on likely future developments.

Measurement of bacterial replication rates in microbial communities


Replication rates of bacteria in both human and environmental microbiomes are measured without reference genome sequences.

Single-cell sequencing of the small-RNA transcriptome


The small RNA transcriptome is sequenced in single cells, facilitating study of microRNAs and other small RNAs.

Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms


Adaptive light-sheet microscopy improves imaging of live organisms by correcting for optical aberrations in real time.

Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library


Long non-coding RNAs are identified using a high-throughput paired-guide RNA genomic deletion screen.

Modeling of RNA-seq fragment sequence bias reduces systematic errors in transcript abundance estimation


Estimates of transcript abundance in RNA-seq data are improved by accounting for sample-specific biases.

Interactive and scalable biology cloud experimentation for scientific inquiry and education


A real-time interactive, fully automated, low-cost and scalable biology cloud experimentation platform could provide access to scientific experimentation for learners and researchers alike.