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Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.



 



The problem with neoantigen prediction

2017-02-08

Personalized immunotherapy is all the rage, but neoantigen discovery and validation remains a daunting problem.





















Correction

2017-02-08










Drug pipeline: 4Q16

2017-02-08




Fresh from the biotech pipeline—2016

2017-01-30

Despite last year's sharp decline in approvals, registrations of two RNA drugs offer a window into the current state and possible future of drug development. Looking forward, the sector seeks greater clarity on the new presidential administration's priorities and the impact of new healthcare legislation. Chris Morrison reports.



So you want to be a student entrepreneur?

2017-02-08

Practical tips for graduate students with an aspiration to start a life science venture.






Situating brain regions among patent rights and moral risks

2017-02-08

What is the ethical value of awarding patent rights that implicate regions of the brain?






Core promoters across the genome

2017-02-08

Promoter strength is measured genome-wide with two high-throughput reporter assays.



Exploring protein sequence–function landscapes

2017-02-08

The effects of sequence variation on function are elucidated by a study of protein evolution.



Research Highlights

2017-02-08







Mutation effects predicted from sequence co-variation

2017-01-16

The global effects of epistasis on protein and RNA function are revealed by an unsupervised model of amino acid co-conservation in evolutionary sequence variation.



Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution

2016-12-26

STAP-seq quantifies the ability of genomic DNA sequences to convert enhancer activities into transcription initiation events.



Genome-wide mapping of autonomous promoter activity in human cells

2016-12-26

The intrinsic strength of promoter sequences in driving transcription is measured across the human genome.



Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

2017-01-23

Cortical neurons are rapidly derived from human pluripotent stem cells using a cocktail of small molecules.



Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

2017-01-16

Mass-cytometry analysis reveals how signaling networks respond to changes in the abundance of their nodes.



Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism

2017-01-16

Cytosolic redox metabolism is rewired to improve lipid yield and productivity in the industrial yeast Yarrowia lipolytica















People

2017-02-08