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cancer  cells  colorectal cancer  drug  ear organoids  ear  editing  human  inner ear  inner  mouse  organoids  stem  transplantation 
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Preview: Nature Biotechnology

Nature Biotechnology

Covering the science and business of biotechnology.


Patient-centered drug manufacture


Bedside production of protein drugs could help payers by lowering drug prices. It may ultimately lead to individualized treatments.

Hanging on a thread


Several companies are now banking on bioengineered silk to create a new generation of textiles and materials...and a necktie. Laura DeFrancesco investigates.

Making individualized drugs a reality


Magistral drug preparation offers a model to circumvent many of the technological, regulatory and financial challenges that prevent provision of the right drug at the right time to the right patient.

Patents as collateral for securitization


Patents are important assets for biotech organizations, not only for protecting inventions but also as assets to raise monies.

Building the human inner ear in an organoid


Inner ear organoids will facilitate disease studies and drug screening.

Manufacture of CAR-T cells in the body


Engineered T cells for cancer therapy are produced in the mouse bloodstream, avoiding the need to harvest T cells and manipulate them ex vivo.

Research Highlights


Open-source, community-driven microfluidics with Metafluidics


A community-led initiative will enable users to design, share, refine and innovate fluidic devices.

Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene


Insertion of the sequence encoding herpes simplex virus 1 thymidine kinase at the breakpoints of fusion genes in cancer cells causes cell death and regression of mouse xenograft tumors.

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development


Analysis of RNA-seq data from individual developing mouse motor neuron cells with topological data analysis sheds light on crucial cell-fate decisions during neurogenesis.

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome


Regulatory elements for specific human genes are rapidly identified with CRISPR epigenome editing.

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis


Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer


Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells


Human pluripotent stem cells are differentiated into inner ear organoids containing cells similar to hair cells and sensory neurons.

A synthetic biology approach to integrative high school STEM training


Synthetic biology–based group activities provide opportunities for integrative STEM training and literacy, while lowering barriers for high school students to become interested in science careers.