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Preview: Nature Biotechnology

Nature Biotechnology



Covering the science and business of biotechnology.



 



Time for the data to speak

2017-08-02

Retraction of a study claiming gene editing via an Argonaute enzyme illustrates the importance of post-publication peer review in the age of 24/7 media.






























Drug pipeline 2Q17

2017-08-08




Engineering the animal out of animal products

2017-08-08

Amber Dance reports on a new wave of domestication—turning cells, rather than animals, into food.





















Big data opens a window onto wellness

2017-08-08

Longitudinal multi-omics data, clinical tests and biomarker analyses across a large cohort lay the groundwork for understanding the transition from wellness to disease.



Pluripotent stem cells that evade the immune radar

2017-08-08

Human pluripotent stem cells are cloaked to evade immune rejection.






Research Highlights

2017-08-08




Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

2017-08-08

Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.



Characterization of noncoding regulatory DNA in the human genome

2017-08-08

Genome-wide mapping of regulatory elements will improve our understanding of how genetic variation in the noncoding genome affects disease phenotypes.



A wellness study of 108 individuals using personal, dense, dynamic data clouds

2017-07-17

Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.



Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy

2017-07-17

Expansion microscopy, a technique for super-resolution imaging, is extended to clinical human tissue samples that are formalin fixed, paraffin embedded, stained and/or fresh frozen.



HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

2017-05-15

Expression of the minimally polymorphic HLA-E molecule prevents NK-cell-mediated rejection of cells lacking expression of HLA-A, B and C.



Long time-lapse nanoscopy with spontaneously blinking membrane probes

2017-07-03

Super-resolution imaging of the dynamics of organelle structures in live cells is facilitated by blinking, far-red dyes.



Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS

2017-06-12

Detection of post-translational modifications by mass spectrometry is enhanced with an analytic method for data-independent acquisition proteomics.



Engineered Cpf1 variants with altered PAM specificities

2017-06-05

The targeting range of the CRISPR endonuclease Cpf1 is increased three-fold by molecular engineering.



Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly

2017-05-15

Rapid cloning of genes from any crop plant species (or cultivar) whose chromosomes can be flow sorted is enabled by a combination of short-read sequencing and proximity ligation.


















People

2017-08-08