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Preview: Nature Biotechnology

Nature Biotechnology



Covering the science and business of biotechnology.



 



Patient-centered drug manufacture

2017-06-07

Bedside production of protein drugs could help payers by lowering drug prices. It may ultimately lead to individualized treatments.



























Hanging on a thread

2017-06-07

Several companies are now banking on bioengineered silk to create a new generation of textiles and materials...and a necktie. Laura DeFrancesco investigates.









Making individualized drugs a reality

2017-06-05

Magistral drug preparation offers a model to circumvent many of the technological, regulatory and financial challenges that prevent provision of the right drug at the right time to the right patient.



Patents as collateral for securitization

2017-06-07

Patents are important assets for biotech organizations, not only for protecting inventions but also as assets to raise monies.






Building the human inner ear in an organoid

2017-06-07

Inner ear organoids will facilitate disease studies and drug screening.



Manufacture of CAR-T cells in the body

2017-06-07

Engineered T cells for cancer therapy are produced in the mouse bloodstream, avoiding the need to harvest T cells and manipulate them ex vivo.



Research Highlights

2017-06-07







Open-source, community-driven microfluidics with Metafluidics

2017-06-07

A community-led initiative will enable users to design, share, refine and innovate fluidic devices.






Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene

2017-05-01

Insertion of the sequence encoding herpes simplex virus 1 thymidine kinase at the breakpoints of fusion genes in cancer cells causes cell death and regression of mouse xenograft tumors.



Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

2017-05-01

Analysis of RNA-seq data from individual developing mouse motor neuron cells with topological data analysis sheds light on crucial cell-fate decisions during neurogenesis.



CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

2017-04-03

Regulatory elements for specific human genes are rapidly identified with CRISPR epigenome editing.



In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

2017-05-01

Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.



Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

2017-05-01

Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.



Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

2017-05-01

Human pluripotent stem cells are differentiated into inner ear organoids containing cells similar to hair cells and sensory neurons.



A synthetic biology approach to integrative high school STEM training

2017-06-07

Synthetic biology–based group activities provide opportunities for integrative STEM training and literacy, while lowering barriers for high school students to become interested in science careers.



People

2017-06-07