Subscribe: pubmed: 0006-3223
http://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=0ut9shIpVdZklUirL_bQX52m8hU8eaD6z4ShcFcmuvq
Preview: pubmed: 0006-3223

pubmed: 0006-3223



NCBI: db=pubmed; Term=0006-3223



 



A Case of Recovery After Delayed Intracranial Hemorrhage After Deep Brain Stimulation for Treatment-Resistant Depression.
Related Articles

A Case of Recovery After Delayed Intracranial Hemorrhage After Deep Brain Stimulation for Treatment-Resistant Depression.

Biol Psychiatry. 2017 May 02;:

Authors: Richieri R, Borius PY, Cermolacce M, Millet B, Lançon C, Régis J

PMID: 28527567 [PubMed - as supplied by publisher]




Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using (31)P-Magnetic Resonance Spectroscopy.
Related Articles

Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using (31)P-Magnetic Resonance Spectroscopy.

Biol Psychiatry. 2017 Apr 07;:

Authors: Du F, Yuksel C, Chouinard VA, Huynh P, Ryan K, Cohen BM, Öngür D

Abstract
BACKGROUND: Brain energy metabolism is critical for supporting synaptic function and information processing. A growing body of evidence suggests abnormalities in brain bioenergetics in psychiatric disorders, including both bipolar disorder (BD) and schizophrenia. (31)P magnetic resonance spectroscopy provides a noninvasive window into these processes in vivo. Using this approach, we previously showed that patients with BD show normal adenosine triphosphate (ATP) and phosphocreatine levels at rest but cannot maintain normal ATP levels in the visual cortex during times of high energy demand (photic stimulation). Because ATP is replenished from phosphocreatine via the creatine kinase reaction, we have now measured the creatine kinase forward reaction rate constant in BD.
METHODS: We studied 20 patients experiencing a first episode of BD and 28 healthy control participants at 4T and quantified creatine kinase forward reaction rate constant using (31)P magnetization transfer magnetic resonance spectroscopy as described previously.
RESULTS: We found a significant reduction in creatine kinase forward reaction rate constant in the BD group (F = 4.692, p = .036), whereas brain ATP and phosphocreatine concentrations, as well as brain parenchymal pH, were normal.
CONCLUSIONS: These results pinpoint a specific molecular mechanism underlying our previous observation of an inability to replenish brain ATP during times of high energy demand in BD.

PMID: 28527566 [PubMed - as supplied by publisher]