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Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder.
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Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder.

Biol Psychiatry. 2017 Aug 18;:

Authors: Scifo E, Pabba M, Kapadia F, Ma T, Lewis DA, Tseng GC, Sibille E

Abstract
BACKGROUND: Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from life-long recurring episodes of increasing severity, reduced therapeutic response, and shorter remission periods, suggesting the presence of a persistent and potentially progressive pathology.
METHODS: Subgenual anterior cingulate cortex postmortem samples from four MDD cohorts (single episode, n = 20; single episode in remission, n = 15; recurrent episode, n = 20; and recurrent episode in remission, n = 15), and one control cohort (n = 20) were analyzed by mass spectrometry-based proteomics (n = 3630 proteins) combined with statistical analyses. The data was investigated for trait and state progressive neuropathologies in MDD using both unbiased approaches and tests of a priori hypotheses.
RESULTS: The data provided weak evidence for proteomic differences as a function of state (depressed/remitted) or number of previous episodes. Instead it suggested the presence of persistent MDD effects, regardless of episodes or remitted state, namely on proteomic measures related to presynaptic neurotransmission, synaptic function, cytoskeletal rearrangements, energy metabolism, phospholipid biosynthesis/metabolism, and calcium ion homeostasis. Selected proteins (dihydropyrimidinase-related protein 1, synaptosomal-associated protein 29, glutamate decarboxylase 1, metabotropic glutamate receptor 1, and excitatory amino acid transporter 3) were validated by Western blot analysis. The findings were independent of technical, demographic (sex or age), or other clinical parameters (death by suicide and drug treatment).
CONCLUSIONS: Collectively, the results provide evidence for persistent MDD effects across current episodes or remission, in the absence of detectable progressive neuropathology.

PMID: 28935211 [PubMed - as supplied by publisher]




Individual Differences Make a Marker in Fear Research.
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Individual Differences Make a Marker in Fear Research.

Biol Psychiatry. 2017 Oct 15;82(8):e65-e66

Authors: Prater KE

PMID: 28935099 [PubMed - in process]




Your System Has Been Hijacked: The Neurobiology of Chronic Pain.
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Your System Has Been Hijacked: The Neurobiology of Chronic Pain.

Biol Psychiatry. 2017 Oct 15;82(8):e61-e63

Authors: Baller EB, Ross DA

PMID: 28935098 [PubMed - in process]




Identifying Potential Mechanisms of Action Underlying Neurofeedback Treatment Response in Depression.
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Identifying Potential Mechanisms of Action Underlying Neurofeedback Treatment Response in Depression.

Biol Psychiatry. 2017 Oct 15;82(8):547-548

Authors: Hampson M

PMID: 28935097 [PubMed - in process]




The Effect of Acute Stress on the Calculus of Reward and Punishment.
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The Effect of Acute Stress on the Calculus of Reward and Punishment.

Biol Psychiatry. 2017 Oct 15;82(8):544-546

Authors: Paulus MP

PMID: 28935096 [PubMed - in process]




Polyunsaturated Fatty Acids, Highly Unsaturated Fatty Acids, and Perinatal Depression.
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Polyunsaturated Fatty Acids, Highly Unsaturated Fatty Acids, and Perinatal Depression.

Biol Psychiatry. 2017 Oct 15;82(8):542-543

Authors: Yonkers KA

PMID: 28935095 [PubMed - in process]