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NCBI: db=pubmed; Term=("Journal of controlled release : official journal of the Controlled Release Society"[Jour])



 



The lack of IVIVC for monoacyl phospholipid-based self-emulsifying drug delivery systems.
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The lack of IVIVC for monoacyl phospholipid-based self-emulsifying drug delivery systems.

J Control Release. 2017 Jun 10;255:279

Authors: Park K

PMID: 28539182 [PubMed - in process]




PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.
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PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.

J Control Release. 2017 May 20;:

Authors: Grossen P, Witzigmann D, Sieber S, Huwyler J

Abstract
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at the site of action and decreased off-target effects. In this review, we discuss state-of-the-art nanomedicines based on PEG-PCL that have been investigated in a preclinical setting. We summarize the various synthesis routes and different preparation methods used for the production of PEG-PCL nanoparticles. Additionally, we review physico-chemical properties including biodegradability, biocompatibility, and drug loading. Finally, we highlight recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi-component therapies, theranostics or gene delivery systems.

PMID: 28536049 [PubMed - as supplied by publisher]