The Relationship between Calciotropic Hormones, IGF1, and Bone Mass across Pubertal Stages.
J Clin Endocrinol Metab. 2016 Sep 27;:jc20163071
Authors: Matar M, Al-Shaar L, Maalouf J, Nabulsi M, Arabi A, Choucair M, Tamim H, Fuleihan GE
BACKGROUND: Little is known about the changes in calciotropic hormones during puberty and their relationship to bone mass during this critical period for skeletal accretion.
OBJECTIVES: Investigate changes in calciotropic hormones, IGF1, body composition and their associations with bone metabolism in adolescents.
METHODS: Post-hoc analyses from data on 335 healthy school children, ages 10-17 years, with hypovitaminosis D, who participated in a vitamin D randomized controlled trial. Baseline serum biochemistries, hormonal studies, densitometry at the spine, hip and total body and body composition were used. Analysis of variance (ANOVA) and regression analyses were implemented to evaluate changes in variables of interest across pubertal stages, within and between genders.
RESULTS: Bone mass and body composition parameters increased substantially across Tanner stages, in both genders. Serum calcium, 1,25 dihydroxyvitamin D, 25(OH)D levels did not vary by Tanner stages, in both genders. Conversely, serum phosphorus, alkaline phosphatase, IGF1, PTH, and osteocalcin peaked for the most part at Tanner stage II in girls and III in boys. 1,25 dihydroxyvitamin D correlations with bone mass were not consistent, whereas IGF1 was the most robust correlate of bone mass, at several skeletal sites, in early Tanner Stages, in both genders, R= 0.3-0.6.
CONCLUSION: Serum phosphorus, alkaline phosphatase, IGF1 and PTH, osteocalcin, but not calcium, or 1,25 dihydroxyvitamin D, increased significantly in early puberty, with gender difference except for PTH, peaking earlier in girls compared to boys. IGF-1 is a robust predictor of bone mass, an effect mediated in large part by increments in lean mass.
PMID: 27676398 [PubMed - as supplied by publisher]
Impact of Parity on Body Size Phenotype in Postmenopausal Women: KNHANES 2010-2012.
J Clin Endocrinol Metab. 2016 Sep 27;:jc20162823
Authors: Kim JH, Kim J, Ahn HJ, Kim SY, Bae HY
CONTEXT: Parity has been implicated in many health consequences for women in later life.
OBJECTIVE: To determine whether there is an association between parity and body size phenotypes in postmenopausal women.
DESIGN AND PARTICIPANTS: This study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES), conducted during 2010-2012. Of the 25,534 participants, data from 3,347 postmenopausal women were included in the analysis.
RESULTS: In analyses stratified by the metabolically abnormal obese (MAO) and metabolically healthy and normal weight (MHNW) phenotypes, women with parities of 3-4 births or ≥ 5 births were significantly associated with the MAO phenotype (OR 1.396 [95% CI 1.077-1.810] and OR 1.978 [1.392-2.811], respectively) compared with those with a parity of 1-2 births after adjusting for age, sociodemographic factors, lifestyle behaviors, and reproductive factors. A similar significant association of parity with the MAO phenotype was also found when we analyzed the parity number as a continuous variable in a comparison of the MAO and metabolically abnormal but normal weight (MANW) phenotypes (OR 1.116 [1.012-1.232]). In grouping of the MAO and metabolically healthy but obese (MHO) phenotypes, women who had experienced a parity of 3-4 births or ≥ 5 births were significantly associated with the MAO phenotype (OR 1.459 [1.025-2.076] and OR 1.989 [1.211-3.265], respectively) after adjustment for the above covariates.
CONCLUSIONS: Parity influenced the body size phenotype in postmenopausal women, and higher parity was independently associated with a higher risk of the MAO phenotype in postmenopausal women.
PMID: 27676397 [PubMed - as supplied by publisher]
Healthy subjects differentially respond to dietary capsaicin correlating with the specific gut enterotypes.
J Clin Endocrinol Metab. 2016 Sep 27;:jc20162786
Authors: Kang C, Zhang Y, Zhu X, Liu K, Wang X, Chen M, Wang J, Chen H, Hui S, Huang L, Zhang Q, Zhu J, Wang B, Mi M
CONTEXT: Previous population studies in evaluating the beneficial effects of capsaicin (CAP) have yielded inconclusive results, and the mechanisms responsible for possible benefit remain unclear.
OBJECTIVE: The objective was to assess the impact of dietary CAP on metabolic and immune profiles and its potential associations with gut microbial patterns in healthy adults.
DESIGN: In a 6-week controlled feeding trial, subjects were given the weight maintenance diet sequentially contained with 0, 5, 0 and 10 mg/d CAP from chili powder.
SETTING AND PARTICIPANTS: The study was conducted in 12 healthy subjects enrolled in Third Military Medical University in Chongqing.
MAIN OUTCOME MEASURES: At the end of each period, anthropometric and basal metabolism measures together with blood and fecal samples were collected. Plasma metabolic and inflammatory markers and gut microbial ecology of each subject were subsequently assessed.
RESULT: Dietary CAP increased the Firmicutes/Bacteroidetes ratio and Faecalibacterium abundance, accompanied with increased plasma levels of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) and decreased plasma ghrelin level. Further enterotype analysis revealed that these subjects could be clustered into Bacteroides enterotype (E1) and Prevotella enterotype (E2), and the above beneficial effects were mainly obtained in E1 subjects. Moreover, E1 subjects had significantly higher fecal Faecalibacterium abundance and butyrate concentration after CAP interventions than those in E2 subjects.
CONCLUSION: Our study showed that gut enterotypes may influence the beneficial effects of dietary CAP, providing a new evidence for the personalized nutrition guidance of CAP intervention on health promotion linking with gut microbiota patterns.
PMID: 27676396 [PubMed - as supplied by publisher]
Urinary citrate, an index of acid-base status, predicts bone strength in youths and fracture risk in adult females.
J Clin Endocrinol Metab. 2016 Sep 27;:jc20162677
Authors: Esche J, Johner S, Shi L, Schönau E, Remer T
CONTEXT: Diet can impact on bone strength via metabolic shifts in acid-base status. In contrast to the strongly diet-dependent biomarker urinary potential renal acid load (uPRAL), the amount of renally excreted citrate integrates nutritional and systemic influences on acid-base homeostasis with high citrate indicating preferential alkalization.
OBJECTIVE: To examine the association between urinary citrate excretion and bone strength as well as long-term fracture risk.
DESIGN AND PARTICIPANTS: Prospective cross-sectional analysis; 231 healthy children (6-18 years) of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study were included, with at least two urine collections available during the four years preceding peripheral quantitative computed tomography (pQCT) of the nondominant proximal forearm. uPRAL, urinary citrate and urinary nitrogen (uN) excretion were quantified in 857 24-h urine samples. Data on overall fracture incidence were collected within a 15 year follow-up after pQCT measurement.
MAIN OUTCOME MEASURES: Parameters of bone quality and geometry (pQCT) as well as long-term fracture incidence.
RESULTS: After controlling for confounders, especially forearm length, muscle area, and uN (biomarker of protein intake), urinary citrate excretion was positively associated with various parameters of bone quality and geometry (p<0.05). Fracture risk in adult females, but not in males, was inversely associated with urinary citrate and positively with uPRAL (p<0.05).
CONCLUSIONS: Although urinary citrate has to be confirmed as an integrated noninvasive biomarker of systemic acid-base status in further studies, our results substantiate dietary and metabolic acidity as potentially adverse for bone health in the long run from childhood onward.
PMID: 27676395 [PubMed - as supplied by publisher]
Autoimmune Diseases in Children and Adults with Type 1 Diabetes from the T1D Exchange Clinic Registry.
J Clin Endocrinol Metab. 2016 Sep 27;:jc20162478
Authors: Hughes JW, Riddlesworth TD, DiMeglio LA, Miller KM, Rickels MR, McGill JB, T1D Exchange Clinic Network
BACKGROUND: and aims: Type 1 diabetes (T1D) is associated with other autoimmune diseases (AID), but the prevalence and associated predictive factors for these comorbidities of T1D across all age groups have not been fully characterized.
MATERIALS AND METHODS: Data obtained from 25759 participants with T1D enrolled in the T1D Exchange Registry were used to analyze the types and frequency of AID, as well as their relationships to gender, age, and race/ethnicity. Diagnoses of autoimmune diseases, represented as ordinal categories (0, 1, 2, 3 or more AID) were obtained from medical records of Exchange Registry participants.
RESULTS: Among the 25759 T1D Exchange participants, 50% were female, 82% non-Hispanic white, mean age was 23.0±16.9 years and mean duration of diabetes 11 years. Of these participants, 6876 (27%) were diagnosed with at least one AID. Frequency of 2 or more AID increased from 4.3% in participants aged <13 years to 10.4% in those aged ≥50 years. The most common AID were thyroid (6097, 24%), gastrointestinal (1530, 6%), and collagen vascular diseases (432, 2%). Addison's disease was rare (75, 0.3%). The prevalence of 1 or more AID was increased in females, non-Hispanic Whites, and with older age.
CONCLUSIONS: In the T1D Exchange Clinic Registry, diagnosis of one or more autoimmune diseases in addition to T1D is common, particularly in women, non-Hispanic whites, and older individuals. Results of this study have implications for both primary care and endocrine practice and will allow clinicians to better anticipate and manage the additional autoimmune diseases that develop in patients with T1D.
PMID: 27676394 [PubMed - as supplied by publisher]