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Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells.
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Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells.

J Biomech. 2018 Mar 30;:

Authors: Copley Salem C, Ulrich C, Quilici D, Schlauch K, Buxton ILO, Burkin H

Abstract
Mechanical strain associated with the expanding uterus correlates with increased preterm birth rates. Mechanical signals result in a cascading network of protein phosphorylation events. These signals direct cellular activities and may lead to changes in contractile phenotype and calcium signaling. In this study, the complete phospho-proteome of uterine smooth muscle cells subjected to mechanical strain for 5 min was compared to un-strained controls. Statistically significant, differential phosphorylation events were annotated by Ingenuity Pathway Analysis to elucidate mechanically induced phosphorylation networks. Mechanical strain leads to the direct activation of ERK1/2, HSPB1, and MYL9, in addition to phosphorylation of PAK2, vimentin, DOCK1, PPP1R12A, and PTPN11 at previously unannotated sites. These results suggest a novel network reaction to mechanical strain and reveal proteins that participate in the activation of contractile mechanisms leading to preterm labor.

PMID: 29661501 [PubMed - as supplied by publisher]