Subscribe: pubmed: 1073-449X
http://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=00KaQC4svDBoCmEttsNSWu82uCxPJQr7JEIhoCQBrZ9
Preview: pubmed: 1073-449X

pubmed: 1073-449X



NCBI: db=pubmed; Term=1073-449X



 



Core Outcome Measures for Clinical Research in Acute Respiratory Failure Survivors: An International Modified Delphi Consensus Study.
Related Articles

Core Outcome Measures for Clinical Research in Acute Respiratory Failure Survivors: An International Modified Delphi Consensus Study.

Am J Respir Crit Care Med. 2017 May 24;:

Authors: Needham DM, Sepulveda KA, Dinglas VD, Chessare CM, Aronson Friedman L, Bingham Iii CO, Turnbull AE

Abstract
RATIONALE: Research evaluating acute respiratory failure (ARF) survivors' outcomes after hospital discharge has substantial heterogeneity in measurement instruments used, creating barriers to synthesizing study data.
OBJECTIVES: To identify a minimum set of core outcome measures that are essential to include in all clinical research studies evaluating ARF survivors after discharge.
METHODS: A three-round modified Delphi consensus process with 77 participants (47% female, 55% outside USA), including clinical researchers from >16 countries across 6 continents, patients/caregivers, clinicians, and research funders. Participants reviewed standardized information on measure instruments for 7 consensus-derived outcomes plus 1 recommended outcome.
MEASUREMENTS AND MAIN RESULTS: Response rates were 91%-97% across the 3 rounds. Among 75 measurement instruments evaluated, the following met a priori consensus criteria: EQ-5D and SF-36v2 (optional) for the "satisfaction with life and personal enjoyment" and "pain" outcomes, and both Hospital Anxiety and Depression Scale, and Impact of Events Scale-Revised for the "mental health" outcome. No measures reached consensus for the following outcomes: cognition, muscle and/or nerve function, physical function, and pulmonary function. All measures considered for pulmonary function met consensus for exclusion. The following measures did not reach the threshold for consensus, but achieved the highest scores for their respective outcomes: Montreal Cognitive Assessment (cognition), manual muscle testing and handgrip dynamometry (muscle and/or nerve function), and 6-minute walk test (physical function).
CONCLUSIONS: This Core Outcome Measurement Set is recommended for use in all clinical research evaluating ARF survivors after hospital discharge. Future research should evaluate measures for outcomes not reaching consensus.

PMID: 28537429 [PubMed - as supplied by publisher]