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pubmed: 0091-6749



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Abnormal CD161(+) Immune Cells and RORΓT Mediated Enhanced IL-17F Expression in Genetic Hypertension.
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Abnormal CD161(+) Immune Cells and RORΓT Mediated Enhanced IL-17F Expression in Genetic Hypertension.

J Allergy Clin Immunol. 2017 Jan 13;:

Authors: Singh MV, Cicha MZ, Kumar S, Meyerholz DK, Irani K, Chapleau MW, Abboud FM

Abstract
BACKGROUND: Hypertension is considered an immunological disorder. However, the role of IL-17 family in genetic hypertension of the spontaneously hypertensive rat (SHR) has not been investigated.
OBJECTIVE: We tested the hypothesis that enhanced Th17 programming and IL-17 expression in abundant CD161+ immune cells in SHR represent an abnormal proinflammatory adaptive immune response. Furthermore, we propose that this response is driven by the master regulator RORγt and a nicotinic proinflammatory innate immune response.
METHODS: We measured the expression of CD161 surface marker on splenocytes in SHR and normotensive control Wistar-Kyoto (WKY) rats from birth to adulthood. We compared expression of IL-17A and IL-17F in splenic cells under different conditions. We then determined the functional effect of these cytokines on vascular reactivity. Finally, we tested whether pharmacological inhibition of RORγt can attenuate hypertension in SHR.
RESULTS: The SHR exhibited an abnormally large population of CD161+ cells at birth that increased with age reaching more than 30% of the splenocyte population at 38 weeks. The SHR splenocytes constitutively expressed more RORγt than WKY and produced more IL-17F upon induction. Exposure of WKY aorta to IL-17F impaired endothelium-dependent vascular relaxation whereas IL-17A did not. Moreover, in vivo inhibition of RORγt by digoxin lowered systolic blood pressure in SHR.
CONCLUSIONS: SHR has a markedly enhanced potential for RORγt -driven expression of proinflammatory, pro-hypertensive IL-17F in response to innate immune activation. Increased RORγt and IL-17F contribute to SHR hypertension and may be potential therapeutic targets.

PMID: 28093217 [PubMed - as supplied by publisher]




Longitudinal variation of serum periostin in adults with stable asthma.
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Longitudinal variation of serum periostin in adults with stable asthma.

J Allergy Clin Immunol. 2017 Jan 13;:

Authors: Semprini R, Caswell-Smith R, Fingleton J, Holweg C, Matthews J, Weatherall M, Beasley R, Braithwaite I, Periostin Study Team

Abstract
We have shown that serum periostin levels are stable within an individual with well-controlled asthma and have little seasonal variation. These are desirable characteristics if serum periostin is to be used as a biomarker in asthma.

PMID: 28093216 [PubMed - as supplied by publisher]