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pubmed: "Allergology interna...



NCBI: db=pubmed; Term=("Allergology international : official journal of the Japanese Society of Allergology"[Jour])



 



Barrier dysfunction in the skin allergy.

Barrier dysfunction in the skin allergy.

Allergol Int. 2017 Nov 16;:

Authors: Egawa G, Kabashima K

Abstract
The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed.

PMID: 29153780 [PubMed - as supplied by publisher]