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pubmed: J Clin Oncol[jour]



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Genetic Testing: What Problem Are We Trying to Solve?

Genetic Testing: What Problem Are We Trying to Solve?

J Clin Oncol. 2017 Aug 18;:JCO2017747899

Authors: Hughes KS

PMID: 28820645 [PubMed - as supplied by publisher]




National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer.

National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer.

J Clin Oncol. 2017 Aug 18;:JCO2017736314

Authors: Childers CP, Childers KK, Maggard-Gibbons M, Macinko J

Abstract
Purpose In the United States, 3.8 million women have a history of breast (BC) or ovarian cancer (OC). Up to 15% of cases are attributable to heritable mutations, which, if identified, provide critical knowledge for treatment and preventive care. It is unknown how many patients who are at high risk for these mutations have not been tested and how rates vary by risk criteria. Methods We used pooled cross-sectional data from three Cancer Control Modules (2005, 2010, 2015) of the National Health Interview Survey, a national in-person household interview survey. Eligible patients were adult females with a history of BC and/or OC meeting select 2017 National Comprehensive Cancer Network eligibility criteria on the basis of age of diagnosis and family history. Outcomes included the proportion of individuals reporting a history of discussing genetic testing with a health professional, being advised to undergo genetic testing, or undergoing genetic testing for BC or OC. Results Of 47,218 women, 2.7% had a BC history and 0.4% had an OC history. For BC, 35.6% met one or more select eligibility criteria; of those, 29.0% discussed, 20.2% were advised to undergo, and 15.3% underwent genetic testing. Testing rates for individual eligibility criteria ranged from 6.2% (relative with OC) to 18.2% (diagnosis ≤ 45 years of age). For OC, 15.1% discussed, 13.1% were advised to undergo, and 10.5% underwent testing. Using only four BC eligibility criteria and all patients with OC, an estimated 1.2 to 1.3 million individuals failed to receive testing. Conclusion Fewer than one in five individuals with a history of BC or OC meeting select National Cancer Comprehensive Network criteria have undergone genetic testing. Most have never discussed testing with a health care provider. Large national efforts are warranted to address this unmet need.

PMID: 28820644 [PubMed - as supplied by publisher]