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Arterial and Venous Thrombosis in Haemophilia Patients: Experiences from a Danish Haemophilia Centre.

Arterial and Venous Thrombosis in Haemophilia Patients: Experiences from a Danish Haemophilia Centre.

Acta Haematol. 2017 Aug 18;138(2):91-95

Authors: Larsen JB, Nielsen KBJ, Poulsen LH, Bor MV

PMID: 28817815 [PubMed - as supplied by publisher]




Green Inclusions in Neutrophils and Monocytes Are an Indicator of Acute Liver Injury and High Mortality.
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Green Inclusions in Neutrophils and Monocytes Are an Indicator of Acute Liver Injury and High Mortality.

Acta Haematol. 2017 Aug 17;138(2):85-90

Authors: Patel N, Hoffman CM, Goldman BI, Bentley K, Burack WR, Evans AG

PMID: 28813697 [PubMed - as supplied by publisher]




Pleural Effusion in Multiple Myeloma: Characteristics and Practice Patterns.
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Pleural Effusion in Multiple Myeloma: Characteristics and Practice Patterns.

Acta Haematol. 2017 Aug 11;138(2):69-76

Authors: Byun JM, Kim KH, Choi IS, Park JH, Kim JS, Shin DY, Koh Y, Kim I, Yoon SS, Lim HJ

Abstract
In many Asian countries battling with the double burden of increasing noninfectious diseases on top of infectious diseases, multiple myeloma (MM) patients presenting with pleural effusion (PE) pose a great diagnostic challenge. Thus, we aimed to analyze the clinical features and practice patterns of such patients. This is a multicenter retrospective study of newly diagnosed MM patients between January 2011 and December 2015. Among 575 MM patients diagnosed during the study period, 80 (13.9%) that were associated with PE were identified and analyzed. The most common cause of PE was parapneumonic (25%), followed by reactive (18.8%). Higher CRP levels and leukocytosis were indicators of parapneumonic PE. There were 7 (8.8%) with myelomatous PE and 2 (2.5%) with tuberculosis. Fifty-six patients underwent additional examinations to determine the exact cause of effusion; 28 patients received computed tomography (CT) of the chest, 5 patients underwent thoracentesis/biopsy, and 23 patients underwent both CT and thoracentesis/biopsy. On the other hand, 24 patients did not undergo additional analyses but were treated empirically. Real-world analyses of practice patterns in MM patients with PE showed the suboptimal use of invasive procedures to determine the exact cause of PE. Since reversible causes and tuberculosis pleurisy are not uncommon, invasive procedures should be actively incorporated as needed.

PMID: 28797003 [PubMed - as supplied by publisher]




Microvessel Density as a Surrogate Prognostic Marker in Patients with Multiple Myeloma: A Meta-Analysis.
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Microvessel Density as a Surrogate Prognostic Marker in Patients with Multiple Myeloma: A Meta-Analysis.

Acta Haematol. 2017 Aug 11;138(2):77-84

Authors: Ntellas P, Perivoliotis K, Dadouli K, Koukoulis GK, Ioannou M

Abstract
BACKGROUND/AIMS: Bone marrow (BM) angiogenesis is considered a hallmark of multiple myeloma (MM) development and progression, and can be quantified with the use of microvessel density (MVD). The purpose of this study is to provide a review and a meta-analysis of the current literature regarding the prognostic value of MVD in the overall survival (OS) of MM patients.
METHODS: MEDLINE was screened for studies evaluating the OS of MM patients with regard to their MVD count in BM trephine. The pooled hazard ratio (HR) and its associated 95% confidence interval (CI) among MM patients with a high and low MVD count was the primary end point. Secondary outcomes included odds ratios (OR) for 12-, 36-, and 60-month survival.
RESULTS: Ten eligible trials were identified for the analysis of the primary end point and 9 for the secondary end points. Pooled HR for OS was 1.85 (95% CI: 1.25-2.73, p = 0.002). The pooled OR of survival were 1.59 (95% CI: 1.02-2.46, p = 0.04) at 12 months, 2.90 (95% CI: 1.68-5.03, p = 0.0001) at 36 months, and 3.42 (95% CI: 2.41-4.85, p < 0.00001) at 60 months, in favor of the low MVD group.
CONCLUSION: This meta-analysis provides persuasive evidence that MVD has significant impact on the clinical outcome of MM patients.

PMID: 28796988 [PubMed - as supplied by publisher]




Pleural Effusion in Multiple Myeloma: A Liquid State.
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Pleural Effusion in Multiple Myeloma: A Liquid State.

Acta Haematol. 2017 Aug 10;138(2):67-68

Authors: Magen H

PMID: 28793303 [PubMed - as supplied by publisher]




An Editor-in-Chief's Farewell.
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An Editor-in-Chief's Farewell.

Acta Haematol. 2017 Aug 10;138(1):

Authors: Ben-Bassat I

PMID: 28793294 [PubMed - as supplied by publisher]




Publisher's Note.
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Publisher's Note.

Acta Haematol. 2017 Aug 10;138(1):

Authors: Karger G

PMID: 28793290 [PubMed - as supplied by publisher]




Passing on the Baton.
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Passing on the Baton.

Acta Haematol. 2017 Aug 10;138(1):

Authors: Raanani P

PMID: 28793289 [PubMed - as supplied by publisher]