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pubmed: Eur J Hem[jour]



NCBI: db=pubmed; Term="European Journal of Haematology"[jour]



 



Bone marrow harvest from unrelated donors - up to date methodology.
Related Articles

Bone marrow harvest from unrelated donors - up to date methodology.

Eur J Haematol. 2017 Jul 18;:

Authors: Pruszczyk K, Skwierawska K, Król M, Moskowicz A, Jabłoński D, Torosian T, Piotrowska I, Urbanowska E, Wiktor-Jędrzejczak W, Snarski E

Abstract
OBJECTIVES: Bone marrow harvesting is one of the essential sources of stem cells for hematopoietic stem cell transplantation. We describe here the current "up to date" standard of the bone marrow harvest in unrelated stem cell donors.
METHODS: We analyzed medical data of 187 unrelated hematopoietic stem cell donors who underwent bone marrow harvest without previous peripheral blood stem collection at the center between 2011 and 2015. The methodology of marrow collection includes multiple cells aimed at safety of the procedure e.g. educational movie, modified skin disinfection protocol, cell enumeration during the procedure, reduction of the contamination surfaces and ongoing monitoring of the quality of work of the doctors.
RESULTS: The total nucleated cell (TNC) count over 2 x 10(8) per kg of recipient has been reached in 93.6% of harvests. All of the donors harvested more than 1 x 10(8) per kg of the recipient. There were no donors who required transfusions or had serious adverse events during and after the harvest.
CONCLUSION: We describe here the current up-to-date standard of bone marrow harvest which leads to excellent results in majority of donors without causing significant complications during the donation This article is protected by copyright. All rights reserved.

PMID: 28719093 [PubMed - as supplied by publisher]




Influence of WHO versus ELN advanced phase chronic myeloid leukemia definitions on overall survival.
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Influence of WHO versus ELN advanced phase chronic myeloid leukemia definitions on overall survival.

Eur J Haematol. 2017 Jul 18;:

Authors: Geelen IGP, Thielen N, Janssen JJWM, Levin MD, Hoogendoorn M, Visser O, Cornelissen JJ, Westerweel PE

Abstract
With great interest, we read the recent article by Söderlund et al. in your journal describing the incidence, patient characteristics and outcome of Swedish patients with chronic myeloid leukemia (CML) in accelerated phase (AP) or blast crisis (BC) (1). The authors compared observations in a Swedish population-based cohort to published intervention trials and found similar results in patient outcome. Of note however, the authors classified their cases using the diagnostic criteria defined by the World Health Organization (WHO) (2). It is important to appreciate that the WHO (2) and European LeukemiaNet (ELN) (3) are inconsistent in their definitions of AP and BC. According to the WHO definition, CML-patients with 10-19% blasts in blood or bone marrow are considered in AP and patients with a blast rate of 20% or more are defined as in BC, whereas the ELN characterizes blast rates between 15-29% as AP and 30% or above as BC. This may confound comparisons with the referenced clinical trials as these used the ELN diagnostic criteria for inclusion (4-8). This article is protected by copyright. All rights reserved.

PMID: 28718971 [PubMed - as supplied by publisher]