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Hyperlipidemia is a risk factor for osteonecrosis in children and young adults with acute lymphoblastic leukemia.
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Hyperlipidemia is a risk factor for osteonecrosis in children and young adults with acute lymphoblastic leukemia.

Haematologica. 2017 Feb 16;:

Authors: Mogensen SS, Schmiegelow K, Grell K, Albertsen BK, Wehner PS, Kampmann P, Frandsen TL

PMID: 28209659 [PubMed - as supplied by publisher]




Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the NHL-BFM protocols.
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Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the NHL-BFM protocols.

Haematologica. 2017 Feb 16;:

Authors: Rohde M, Bonn BR, Zimmermann M, Lange J, Möricke A, Klapper W, Oschlies I, Szczepanowski M, Nagel I, Schrappe M, Loeffler M, Siebert R, Reiter A, Burkhardt B, ICGC-MMML-Seq, MMML-MYC-SYS

Abstract
Mature B-cell Non-Hodgkin lymphoma is the most common subtype of Non-Hodgkin lymphoma in childhood and adolescence. B-cell Non-Hodgkin lymphoma are further classified into histological subtypes, with Burkitt lymphoma and Diffuse large B-cell lymphoma being the most common subgroups in pediatric patients. Translocations involving the MYC oncogene are known as relevant but not sufficient hit for Burkitt lymphoma pathogenesis. Recently published large-scale next-generation sequencing studies unveiled sets of additional recurrently mutated genes in samples of pediatric and adult B-cell Non-Hodgkin lymphoma patients. ID3, TCF3 and CCND3 are potential drivers of Burkitt-lymphomagenesis. In the present study frequency and clinical relevance of mutations in ID3, TCF3 and CCND3 were analyzed within a well-defined cohort of 84 uniformly diagnosed and treated pediatric B-cell Non-Hodgkin lymphoma patients of the Berlin-Frankfurt-Munster group (NHL-BFM). Mutation frequency was 78% (ID3), 13% (TCF3) and 36% (CCND3) in Burkitt lymphoma (including Burkitt leukemia). ID3 and CCND3 mutations were associated with more advanced stages of the disease in MYC rearrangement positive Burkitt lymphoma. In conclusion ID3-TCF3-CCND3 pathway genes are mutated in more than 88% of MYC-rearranged pediatric B-cell Non-Hodgkin lymphoma and the pathway may represent a highly relevant second hit of Burkitt lymphoma pathogenesis especially in children and adolescents.

PMID: 28209658 [PubMed - as supplied by publisher]




Demystification of enigma on antigen presenting cell features of human basophils: data from secondary lymphoid organs.
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Demystification of enigma on antigen presenting cell features of human basophils: data from secondary lymphoid organs.

Haematologica. 2017 Feb 16;:

Authors: Stephen-Victor E, Das M, Sharma M, Galeotti C, Fohrer-Ting H, Sendid B, Darnige L, Terris B, Badoual C, Bruneval P, Kaveri SV, Bayry J

PMID: 28209657 [PubMed - as supplied by publisher]




Changes in allele frequencies of CSF3R and SETBP1 mutations and evidence of clonal evolution in a chronic neutrophilic leukemia patient treated with ruxolitinib.
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Changes in allele frequencies of CSF3R and SETBP1 mutations and evidence of clonal evolution in a chronic neutrophilic leukemia patient treated with ruxolitinib.

Haematologica. 2017 Feb 16;:

Authors: Nooruddin Z, Miltgen N, Wei Q, Schowinsky J, Pan Z, Tobin J, Purev E, Gutman JA, Robinson W, Pollyea DA

PMID: 28209656 [PubMed - as supplied by publisher]




Mutational analysis in serial marrow samples during azacitidine treatment in patients with post-transplant relapse of acute myeloid leukemia or myelodysplastic syndromes.
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Mutational analysis in serial marrow samples during azacitidine treatment in patients with post-transplant relapse of acute myeloid leukemia or myelodysplastic syndromes.

Haematologica. 2017 Feb 16;:

Authors: Woo J, Howard NP, Storer BE, Fang M, Yeung CC, Scott BL, Deeg HJ

PMID: 28209655 [PubMed - as supplied by publisher]