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pubmed: BMT[Jour]



NCBI: db=pubmed; Term="Bone marrow transplantation"[Jour]



 



Immune reconstitution in patients with acquired severe aplastic anemia after haploidentical stem cell transplantation.

Immune reconstitution in patients with acquired severe aplastic anemia after haploidentical stem cell transplantation.

Bone Marrow Transplant. 2017 Aug 14;:

Authors: Pei XY, Zhao XY, Xu LP, Wang Y, Zhang XH, Chang YJ, Huang XJ

Abstract
Immune recovery (IR) after haploidentical stem cell transplantation (haplo-SCT) in severe aplastic anemia (SAA) patients remains relatively unknown. In this study, we examined immune cell subset counts and immunoglobulins in 81 SAA patients from day 30 to day 365 after haplo-SCT. Simultaneously, we determined which factors influence IR and analyzed the effects of immune cell subsets on transplant outcomes. We found that: (i) The reconstitution of different immune cell subsets occurred at different rates after haplo-SCT. Monocytes were the first to recover, followed by CD8(+) T and CD19(+) B cells, and finally CD4(+) T cells. (ii) In the multivariate analysis, lower recipient age, female gender, high mononuclear cell counts in the graft and absence of CMV reactivation were associated with improved IR after transplant. (iii) A CD4/CD8 ratio less than 0.567 on day 30 post transplantation was associated with higher overall survival after haplo-SCT in SAA patients. In conclusion, SAA patients showed a faster recovery of monocytes and CD8(+) T cells after haplo-SCT, whereas the recovery of the CD4(+) T-cell subset was delayed. Our results may provide insight into methods for better predicting and modulating IR of SAA patients and subsequently improving outcomes after transplantation.Bone Marrow Transplantation advance online publication, 14 August 2017; doi:10.1038/bmt.2017.174.

PMID: 28805792 [PubMed - as supplied by publisher]




Low circulating mannan-binding lectin levels correlate with increased frequency and severity of febrile episodes in myeloma patients who undergo ASCT and do not receive antibiotic prophylaxis.

Low circulating mannan-binding lectin levels correlate with increased frequency and severity of febrile episodes in myeloma patients who undergo ASCT and do not receive antibiotic prophylaxis.

Bone Marrow Transplant. 2017 Aug 14;:

Authors: Eleutherakis-Papaiakovou E, Dimopoulos MA, Kastritis E, Christoulas D, Roussou M, Migkou M, Gavriatopoulou M, Fotiou D, Panagiotidis I, Ziogas DC, Kanellias N, Papadimitriou C, Terpos E

Abstract
Patients with multiple myeloma (MM) who undergo autologous stem cell transplantation (ASCT) are susceptible to severe infections. Low levels of circulating mannan-binding lectin (MBL) are associated with increased risk of infection. In this prospective study, we evaluated 100 patients who underwent ASCT regarding the effect of MBL on the incidence and severity of febrile episodes. Seventeen patients had MBL levels <500 ng/mL (11 received antibiotic prophylaxis and 6 did not). Although there was no statistical difference regarding the development of febrile episodes between patients with low and normal MBL, among 17 patients with low MBL levels, six out of eleven patients who received antibiotic prophylaxis developed a febrile episode compared with six out of six patients who did not receive antibiotic prophylaxis and developed a febrile episode. Patients with low MBL levels who responded less frequently to first line antibiotic therapy required more frequent administration of a second more advanced line of antibiotics, independently of receiving or not prophylaxis, and required prolonged hospitalization. In the univariate analysis low MBL associated with shorter OS. Our results suggest that patient with low MBL levels should receive antibiotic prophylaxis to reduce the number of febrile episodes and raise the issue of MBL replacement for these patients.Bone Marrow Transplantation advance online publication, 14 August 2017; doi:10.1038/bmt.2017.172.

PMID: 28805791 [PubMed - as supplied by publisher]




Successful reduced intensity hematopoietic cell transplant in a patient with deficiency of adenosine deaminase 2.

Successful reduced intensity hematopoietic cell transplant in a patient with deficiency of adenosine deaminase 2.

Bone Marrow Transplant. 2017 Aug 14;:

Authors: Hashem H, Vatsayan A, Gupta A, Nagle K, Hershfield M, Dalal J

PMID: 28805790 [PubMed - as supplied by publisher]




Multiple myeloma with extramedullary disease: impact of autologous stem cell transplantation on outcome.

Multiple myeloma with extramedullary disease: impact of autologous stem cell transplantation on outcome.

Bone Marrow Transplant. 2017 Aug 14;:

Authors: Kumar L, Gogi R, Patel AK, Mookerjee A, Sahoo RK, Malik PS, Sharma A, Thulkar S, Kumar R, Biswas A, Sharma OD, Gupta R

PMID: 28805789 [PubMed - as supplied by publisher]