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Biologists unravel another mystery of what makes DNA go 'loopy'

Mon, 19 Mar 2018 09:54:27 +0100

Scientists discovered another key to how DNA forms loops and wraps inside the cell nucleus -- a precise method of "packing" that may affect gene expression. The journal Science published the research by biologists at Emory University, showing that a process known as hemimethylation plays a role in l...

Thermo Fisher Scientific announces plans to build state-of-the-art pharma services facility in Rheinfelden

Mon, 19 Mar 2018 09:46:45 +0100

Thermo Fisher Scientific announced it is expanding its footprint in the European Union and investing $35 million in a state-of-the-art pharma services supply chain facility in Rheinfelden (Baden) Germany. Company representatives joined Mayor Eberhardt at the Rheinfelden council meeting to unveil the...

A small protein with many applications

Mon, 19 Mar 2018 06:00:02 +0100

Researchers from the Department of Molecular Biology and Genetics and from the Department of Biomedicine at Aarhus University have collaboratively developed and described a llama-antibody that might have significant impact for future diagnostics and treatment of, e.g., kidney diseases. The research ...

Sleeping Beauty enables efficient gene transfer in haematopoietic stem cells of humans

Mon, 19 Mar 2018 06:00:00 +0100

Gene therapy of haematopoietic stem cells aims at a life-long therapeutically effective correction of these cells in humans with particular genetic disorders. This therapeutic approach has proved to be effective in clinical trials while the risk of leukaemia development as a side-effect of the thera...

Helicobacter creates immune system blind spot

Fri, 16 Mar 2018 10:12:55 +0100

The gastric bacterium H. pylori colonizes the stomachs of around half the human population and can lead to the development of gastric cancer. It is usually acquired in childhood and persists life-long, despite a strong inflammatory defence reaction in the gastric mucosa. Such inflammation is normall...

An unlikely hero in the global fight against antibiotic resistance

Fri, 16 Mar 2018 06:00:06 +0100

A breakthrough by Australian scientists has brought the introduction of an unlikely hero in the global fight against antibiotic resistance a step closer; the humble platypus. Due to its unique features - duck-billed, egg-laying, beaver-tailed and venomous- the platypus has long exerted a powerful ap...

Artificial and biological cells work together as mini chemical factories

Fri, 16 Mar 2018 06:00:04 +0100

Researchers have fused living and non-living cells for the first time in a way that allows them to work together, paving the way for new applications. The system, created by a team from Imperial College London, encapsulates biological cells within an artificial cell. Using this, researchers can harn...

New international partnership promises great potential for next-generation biopharmaceuticals

Fri, 16 Mar 2018 06:00:01 +0100

There are a multitude of challenges associated with the production of next-generation biopharmaceuticals and vaccines. The Austrian Centre of Industrial Biotechnology and the BOKU - University of Natural Resources and Life Sciences, Vienna together with the Boyce Thompson Institute (BTI) Ithaca, NY ...

A new piece in the puzzle of how herpesviruses outwit the immune system

Thu, 15 Mar 2018 13:00:00 +0100

Humans are constantly exposed to pathogens like bacteria and viruses. In most cases, the immune system successfully detects and eliminates these invaders. However, the herpesvirus family has adapted brilliantly to the immune system: its members manage to stay in the host’s body for life after infect...

Synergy of two catalysts in one flask

Thu, 15 Mar 2018 10:16:04 +0100

Most medications, agricultural chemicals and functional materials, indispensable for maintaining and improving our lives, are composed of organic molecules. Organic synthesis using a catalyst is the method for the rapid and large scale supply of such organic molecules without imposing a heavy burden...

Researchers target deadly ‘superbug’

Thu, 15 Mar 2018 06:00:09 +0100

UF Health researchers are developing new antibiotic drug combinations to attack one of the world’s deadliest superbugs. The superbug Acinetobacter baumannii, or A. baumannii, is a bacterial pathogen resistant to many antibiotics. Commonly found in hospitals, nursing homes and other health care facil...

Artificial corneas

Thu, 15 Mar 2018 06:00:08 +0100

It is not unusual for millions of people throughout the world to wait one to two years for a cornea transplant. The “MyCornea” start-up wants to reduce this waiting period to six weeks. The University of Cambridge students behind the startup developed a process for manufacturing artificial corneas. ...

22 new genetic risk factors for stroke identified

Thu, 15 Mar 2018 06:00:02 +0100

Researchers have analyzed genetic data from half a million subjects in a search to identify the underlying causes of stroke, a complex vascular disease. Scientists at LMU led the the huge collaborative Project. Stroke is the second most common cause of both death and disability-adjusted life-years w...

Citoxlab acquires Solvo Biotechnology

Wed, 14 Mar 2018 13:00:01 +0100

Citoxlab Group announced that it has entered into a definitive agreement to acquire Solvo Biotechnology. The closing of this operation will take place within the next month. Financial details were not disclosed. Through this new acquisition Citoxlab reinforces its position in the non-clinical CRO fi...

Brown adipose tissue made transparent

Wed, 14 Mar 2018 10:07:11 +0100

Brown adipose tissue has played a key role in prevention research since its presence was first documented in adults. However, there was no non-invasive method of measuring its heat generation. A team at the Technical University Munich (TUM) and the Helmholtz Zentrum München has now succeeded in maki...

BioMed X and Roche announce research collaboration in the field of immunology

Wed, 14 Mar 2018 06:00:07 +0100

BioMed X announced the initiation of a new research collaboration with F. Hoffmann-La Roche Ltd in the field of immunology. Within the framework of the agreement, BioMed X will launch a global call for applications to establish a new biomedical research group in Heidelberg. The main objective of the...

Researchers make a fly’s heartbeat visible

Wed, 14 Mar 2018 06:00:02 +0100

Looking into a tiny fly’s heart: researchers at the Cells-in-Motion Cluster of Excellence at the University of Münster have developed a new method for visualizing the heartbeat of living fruit-fly pupae and automatically recording the pulse frequency. The system has a number of benefits: the images ...

Researchers computationally find the needle in a haystack to treat rare diseases

Wed, 14 Mar 2018 06:00:01 +0100

One in 10 people in America is fighting a rare disease, or a disorder that affects fewer than 200,000 Americans. Although there are more than 7,000 rare diseases that collectively affect more than 350 million people worldwide, it is not profitable for the pharmaceutical industry to develop new thera...

Xeris Pharmaceuticals completes $55 million in new financing

Tue, 13 Mar 2018 13:00:00 +0100

Xeris Pharmaceuticals, Inc., a specialty pharmaceutical company leveraging its novel technology platforms to develop and commercialize ready-to-use injectable and infusible drug formulations, has entered into a $45 million Term Loan and Securities Agreement (“Loan Agreement”) with Silicon Valley Ban...

Novel technology for anticancer drug delivery on demand

Tue, 13 Mar 2018 10:11:01 +0100

With the goal of minimizing the side effects of chemotherapy on healthy tissues, a team of researchers at the Center for Self-assembly and Complexity, within the Institute for Basic Science (IBS) have developed novel nanocontainers able to deliver anticancer drugs at precise timing and location. The...

Inherited mutation leads to overproduction of EPO

Tue, 13 Mar 2018 06:00:11 +0100

A newly-discovered hereditary mutation is responsible for an increased production of erythropoietin (EPO) in the blood. This mutation causes a messenger RNA (mRNA) that is not normally involved in the formation of proteins to be reprogrammed so that it produces EPO, thus abnormally increasing the nu...

UTA startup AbeXXa Biologics, reimagining cancer immunotherapy

Tue, 13 Mar 2018 06:00:04 +0100

AbeXXa Biologics, named as one of the 40 Best University Startups1 in 2017, has received an initial investment from the Boehringer Ingelheim Venture Fund and signed a collaborative research agreement with the global corporation Boehringer Ingelheim. AbeXXa is a faculty start-up from The University o...

A combination drug trial to eradicate B-cell malignancies launched

Tue, 13 Mar 2018 06:00:03 +0100

Fueled by a multimillion dollar grant from the state's stem cell agency, researchers at University of California San Diego School of Medicine, in collaboration with local biotechnology company Oncternal Therapeutics, have launched a phase Ib/II clinical trial to evaluate the combined effectiveness o...

Trends in Analytics: Digitization, detecting novel pollutants and more

Tue, 13 Mar 2018 06:00:00 +0100

From material testing to environmental monitoring: At the analytica, companies and research institutions from all over the world present their latest developments. A glance at the key aspects of the international leading trade fair for laboratory technology, analysis and biotechnology shows: Here, t...

Engineered cartilage template to heal broken bones

Mon, 12 Mar 2018 13:00:00 +0100

A team of UConn Health researchers has designed a novel, hybrid hydrogel system to help address some of the challenges in repairing bone in the event of injury. The UConn Health team, led by associate professor of orthopedic surgery Syam Nukavarapu , described their findings. There are over 200 bone...

Immortal cells for tailor-made active substances

Mon, 12 Mar 2018 10:10:55 +0100

When scientists discover a new active substance, e.g. for use against a pathogen, they usually study its exact effect in cultured cells. But there is a lack of suitable test systems that simulate body tissues, because cells rapidly lose their specific properties once they are away from their natural...

Creating complex molecules in just a few steps

Mon, 12 Mar 2018 06:00:07 +0100

Researchers have found a way to convert single bonds between carbon and hydrogen atoms in a chemical molecule into carbon-carbon bonds. This so-called C-H activation is considered a promising strategy for producing complex molecules from simple starting materials in just a few steps. The main proble...

Global Bioenergy delivers biofuel to Audi

Mon, 12 Mar 2018 06:00:04 +0100

Global Bioenergies and German carmaker Audi announced that a key milestone was reached in their multi-year agreement. Renewable gasoline components were produced and shipped to Audi. Using its Leuna Demo plant, Global Bioenergies has produced high-purity renewable isobutene, which was further conver...

Revolutionizing cancer research with diamonds

Mon, 12 Mar 2018 06:00:01 +0100

Magnetic resonance imaging (MRI) is being revolutionized: With the nanodiamond the tumor tissue can be detected sooner and distinguished better from the healthy surrounding tissue. Aiming at an improvement of the MRI procedure in the joint project »DiaPol« Fraunhofer IAF cooperates with the Universi...

Danaher to acquire Integrated DNA Technologies

Mon, 12 Mar 2018 06:00:00 +0100

Danaher Corporation and Integrated DNA Technologies announced that Danaher has entered into a definitive agreement to acquire IDT, a privately-held provider of high-value consumables for genomics applications in molecular biology, qPCR, next generation sequencing, synthetic biology, gene editing and...

Why asbestos is so dangerous

Fri, 09 Mar 2018 06:00:11 +0100

Long, pointed asbestos fibres induce chronic inflammation, which can lead to cancer. SNSF-funded researchers have found underlying mechanisms for this and hope their results will help prevent damage. The fact that asbestos causes cancer has been largely undisputed for nearly 50 years. Now, research...

Recovery from spinal cord injuries can be predicted

Fri, 09 Mar 2018 06:00:09 +0100

A trauma to the spinal cord, quickly leads to a progressive loss of nerve tissue. This not only affects the injured area, but over time affects also other parts of the spinal cord and even the brain. These neurodegenerative changes can be explored in detail using magnetic resonance imaging. An inter...

How cellular structure orchestrates immunologic memory

Fri, 09 Mar 2018 06:00:06 +0100

With every infection or vaccination, memory cells form that the body uses to remember the pathogen. This has been known for decades – but the structure of this cellular immunologic memory has previously proven impossible to pin down. Researchers from the University of Basel and University Hospital B...

Merck achieves targets for 2017

Fri, 09 Mar 2018 06:00:04 +0100

Merck met its targets for 2017 and achieved important strategic successes with the approvals of two new medicines. Sales increased over the previous year whereas EBITDA pre, which was adversely impacted by negative foreign exchange effects, declined slightly. “2017 was a good year for Merck. We perf...

Agilent Technologies to acquire Advanced Analytical Technologies, Inc.

Fri, 09 Mar 2018 06:00:03 +0100

Agilent Technologies Inc. announced that it has signed a definitive agreement to acquire privately-held Advanced Analytical Technologies, Inc. (AATI), a provider of capillary electrophoresis-based (CE) solutions for fully-automated analysis of a range of molecules for $250 million in cash. This acqu...

SYGNIS completes integration of acquired companies under new brand

Thu, 08 Mar 2018 06:00:13 +0100

SYGNIS AG announced its subsidiaries Innova Biosciences, Expedeon Holdings, and C.B.S. Scientific have united as Expedeon, effective 1 March 2018. The corporate rebranding follows the latest acquisition of Innova Biosciences by SYGNIS AG in June 2017. SYGNIS AG will continue to serve as the parent c...

Sanofi's Board of Directors proposes appointment of Emmanuel Babeau as new independent director

Thu, 08 Mar 2018 06:00:13 +0100

Sanofi's Board of Directors proposed to submit the appointment of Emmanuel Babeau as new independent director, as well as the renewal of the terms of Olivier Brandicourt, Patrick Kron and Christian Mulliez to a shareholders' vote during the general shareholders' meeting on May 2, 2018. Robert Castai...

PAREXEL appoints Jamie Macdonald as Chief Executive Officer

Thu, 08 Mar 2018 06:00:13 +0100

PAREXEL International Corporation announced the appointment of Jamie Macdonald as Chief Executive Officer (CEO) effective March 15, 2018. Josef von Rickenbach, who co-founded the Company, will retire from his daily CEO duties and continue as Chairman of the Board. “It is a tremendous honor for me to...

New tool for structural biology

Thu, 08 Mar 2018 06:00:06 +0100

ETH researchers have developed a new method of crystallising large membrane proteins in order to determine their structure. This will be of benefit to biological research and the pharmaceutical industry. Membrane-embedded proteins are an essential part of cells and any form of life. They not only ex...

New Process for Marker-free Cell Selection

Thu, 08 Mar 2018 06:00:04 +0100

At this year’s analytica trade fair in Munich, three Fraunhofer Institutes will be presenting a project from pre-competitive research. Biologists, computer scientists and laser experts have developed a process to analyze and select cells and then examine their protein production. In pharmaceutical r...

Mapping a genetic risk

Thu, 08 Mar 2018 06:00:02 +0100

The more information you have, the better able you are to predict what will happen next. Clinicians and health researchers often look at gene mutation to predict whether a fetus is at risk for a birth defect, or a person is at risk of developing a disease, but these predictions are not always accura...

How the brain might compensate stress during learning

Thu, 08 Mar 2018 01:00:00 +0100

Friend or foe, chequered or striped – the brain divides everything around us in categories. How the brain manages this task under pressure. When people have to assess a situation within seconds, it helps them to draw on learned categories. Psychologists from the Ruhr-Universität Bochum examined with...

How to target a gene

Thu, 08 Mar 2018 01:00:00 +0100

All living cells have invented mechanisms to protect their DNA against breaks during duplication and against damage by UV-light or chemicals. A team of biologists led by Prof. Dr. Ralf Reski from the Faculty of Biology of the University of Freiburg, Germany has now found that members of the RecQ fam...

Our circadian clock sets the rhythm for our cells’ powerhouses

Wed, 07 Mar 2018 10:10:59 +0100

Cellular energy metabolism also follows the rhythm of the circadian clock. A University of Basel study has now shown exactly how this works by revealing the relationship between the circadian rhythm and the mitochondrial network for the first time. Countless genetically controlled clocks tick inside...

Producing handy gels from a protein found in human blood

Wed, 07 Mar 2018 06:00:08 +0100

From blood to the lab: the protein albumin is responsible for many vital processes in the human body. In nature it only appears as a solution when dissolved in water. Chemists at Martin Luther University Halle-Wittenberg (MLU) have developed a method of producing various albumin-based gels. Their fi...

BRAIN AG establishes US subsidiary

Wed, 07 Mar 2018 06:00:06 +0100

In order to address the North American markets of importance for the BRAIN Group more effectively, the BRAIN AG, headquartered in Zwingenberg, has founded the US subsidiary B.R.A.I.N. Biotechnology Research and Information Network US LLC (short: BRAIN LLC). This strategic step is intended to acceler...

Heidelberg Pharma and Magenta Therapeutics Sign Exclusive Multi-Target Research Agreement

Tue, 06 Mar 2018 13:00:01 +0100

Heidelberg Pharma AG and Magenta Therapeutics Inc., a biotechnology company developing therapeutics to improve and extend the use of curative bone marrow transplant for more patients, announced the signing of an exclusive multi-target research agreement. Heidelberg Pharma Research GmbH signed this c...

Photosynthetic microalgae as biocatalysts

Tue, 06 Mar 2018 10:08:39 +0100

A carpet of blue-green algae can literally ‘cloud’ the summer’s swimming pleasure at the lake. This is caused by a few strains of photosynthetically active microalgae, also known as cyanobacteria. Other harmless strains of cyanobacteria have great potential for biotechnological applications and for ...

When to immunise if blood stem cells are being transplanted?

Tue, 06 Mar 2018 06:00:06 +0100

After undergoing bone marrow or peripheral blood stem cell transplantation, patients experience a loss of vaccine protection. In a project funded by the Austrian Science Fund FWF, the physician Christina Forstner is investigating how such patients respond to TBE vaccination and at what point this sh...

Rapid diagnosis of diseases with novel blood test

Tue, 06 Mar 2018 06:00:02 +0100

Prof. Dr. Jochen Guck, research group leader at the Biotechnology Center of TU Dresden (BIOTEC), together with medical colleagues from the University Hospital Carl Gustav Carus Dresden and partnering institutes from Dresden (Germany), Cambridge (UK), Glasgow (UK), and Stockholm (Sweden) use a techni...