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Shire rejects Takeda's acquisition offers

Fri, 20 Apr 2018 11:49:40 +0200

Shire notes the announcement made by Takeda. The Board of Shire confirms that it has received three conditional proposals from Takeda regarding a possible offer for the Company, on 29 March 2018 (the “First Proposal”), 11 April 2018 (the “Second Proposal”) and 13 April 2018 (the “Third Proposal”). T...

Peptide induces chirality evolution in a single gold nanoparticle

Fri, 20 Apr 2018 11:23:15 +0200

For the first time, scientists have successfully created optically active, chiral gold nanoparticles using amino acids and peptides. Many chemicals significant to life have mirror-image twins (left-handed and right-handed structures), a characteristic that is conventionally called chirality. This st...

DKSH and Bruker AXS sign distribution agreement for Asia Pacific

Fri, 20 Apr 2018 07:00:05 +0200

DKSH Business Unit Technology, a leading Market Expansion Services provider for technology companies seeking to grow their business in Asia, and Bruker AXS, a leading provider of Analytical X-ray Solutions, have signed a multi-product line distribution agreement for South Korea, Australia, New Zeala...

Nanoparticles that could specifically target and kill only cancerous cells

Fri, 20 Apr 2018 07:00:04 +0200

Researchers at the University of Southampton have developed new nanoparticles that can distinguish and penetrate cancerous cells, in a new study which could have major implications for the delivery of anticancer drugs. The team has designed an advanced type of nanoparticle, which is able to carry dr...

Unique binding mechanism of antifreeze molecule identified

Fri, 20 Apr 2018 07:00:02 +0200

Scientists have identified a unique molecular binding mechanism that helps keep non-mammalian creatures in sub-zero temperatures from freezing. Antifreeze glycoproteins (AFGPs), produced by polar fishes, inhibit ice growth to prevent their bodies from freezing. This ice binding mechanism, which scie...

Enduring cold temperatures alters fat cell epigenetics

Fri, 20 Apr 2018 07:00:02 +0200

A new study in fat cells has revealed a molecular mechanism that controls how lifestyle choices and the external environment affect gene expression. This mechanism includes potential targets for next-generation drug discovery efforts to treat metabolic diseases including diabetes and obesity. Resear...

Bruker acquires pioneering IR company

Thu, 19 Apr 2018 15:25:04 +0200

Bruker announced that it has acquired Anasys Instruments Corp., a privately held company that develops and manufactures nanoscale infrared spectroscopy and thermal measurement instruments. This acquisition adds to Bruker’s portfolio of Raman and FTIR spectrometers, as well as to its nanoscale surfac...

Merck to Sell Consumer Health to Procter & Gamble

Thu, 19 Apr 2018 11:48:39 +0200

Merck announced that it has signed an agreement to sell its global Consumer Health business to Procter & Gamble (P&G) for approximately € 3.4 billion in cash, or approximately $ 4.2 billion at current exchange rates. The transaction, which is expected to close by the end of the fourth quarter 2018, ...

How the internal compass is constructed in magnetotactic bacteria

Thu, 19 Apr 2018 11:13:20 +0200

Magnetotactic bacteria are usually found in freshwater and marine sediments. One species, Magnetospirillum gryphiswaldense, is easily cultivated in the lab - with or without magnetic nanoparticles in their interior depending on the presence or absence of iron in the local environment. "So these micr...

Is it time to abandon the Nobel Prize?

Thu, 19 Apr 2018 07:00:13 +0200

In a commentary piece authors Clare Fiala and Eleftherios P. Diamandis spawned a debate now further nourished by recent disclosures. Fiala and Diamandis argue that it is time to abandon the Nobel Prize in favor of alternative recognitions which encompass the collaborative nature of modern science. I...

Researchers succeed in cultivating cartilage from stem cells

Thu, 19 Apr 2018 07:00:09 +0200

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journ...

Enigmatic gene critical for a healthy brain

Thu, 19 Apr 2018 07:00:05 +0200

Since the human genome was first sequenced in 2001, scientists have puzzled over swathes of our DNA that despite apparently lacking function are made into ribonucleic acid (RNA) by the cell. Why make RNA at all when it is not then used to make proteins, which perform fundamental biological tasks? Pe...

Evotec and Bayer advance third endometriosis programme into Phase I clinical development

Thu, 19 Apr 2018 07:00:02 +0200

Evotec AG announced that its multi-target alliance with Bayer has advanced another promising small molecule into Phase I for the treatment of endometriosis, a painful, debilitating reproductive condition that affects approximately 176 million women worldwide. This milestone was achieved under the hi...

Technology measures tumors' drug resistance up to 10 times faster

Wed, 18 Apr 2018 11:26:45 +0200

A group of scientists from VCU Massey Cancer Center and UCLA Jonsson Comprehensive Cancer Center have developed a new, high-speed microscopy platform that can measure a cancer cell's resistance to drugs up to 10 times faster than existing technology, potentially informing more effective treatment se...

Crescendo Biologics first major milestone in collaboration with Takeda reached

Wed, 18 Apr 2018 07:00:19 +0200

Crescendo Biologics Ltd, the developer of multifunctional biologics, including targeted T-cell engagers, announced that it has achieved the first major technical milestone under the terms of its collaboration with Takeda Pharmaceutical Company Limited. The global, strategic, multi-target collaborati...

Systematic analysis of data from animal models reveals opportunities and limitations

Wed, 18 Apr 2018 07:00:15 +0200

What opportunities and what limits result from the use of laboratory animals in the preclinical and clinical research? Neurologist Malcolm Macleod has dedicated himself to this topic. For his interdisciplinary research work and his contribution to improving animal welfare, he is awarded this year's ...

Sanofi sells European generics business

Wed, 18 Apr 2018 07:00:07 +0200

Advent International and Sanofi have entered into exclusive negotiations under which Advent would acquire Zentiva, Sanofi's European generics business for €1,9 billion. Advent's offer is firm, binding and fully financed. Advent is a global investor, with over 25 years' experience of investing in the...

Course set to overcome mismatch between lab-designed nanomaterials and nature's complexity

Wed, 18 Apr 2018 07:00:01 +0200

Cells and the machinery they encase are soft matter -- shape-shifting multicomponent systems with an overwhelming richness of forms. But, these squishy packages are hard targets for potential therapeutic and diagnostic applications that exploit nanomaterials, from quantum dots that light up specific...

Sartorius Stedim supports biotech training at U Penn

Tue, 17 Apr 2018 14:00:00 +0200

Sartorius Stedim Biotech andPenn State University have entered into a collaborative partnership to advance multidisciplinary teaching and research in biotechnology. This long-term relationship will support the education and preparation of the next generation of biotechnology leaders. Part of Sartori...

WACKER Buys Dutch Biotechnology Plant

Tue, 17 Apr 2018 13:02:04 +0200

Wacker Chemie AG has acquired a Dutch site for manufacturing biopharmaceuticals, live microbial products and vaccines, plus the associated business, from SynCo Bio Luxembourg S.à.r.l.. For WACKER, maintaining SynCo’s existing customer relationships is a top priority. Moreover, WACKER is keeping on S...

Memory part of the brain may also hold clues for anxiety and depression

Tue, 17 Apr 2018 07:00:11 +0200

The hippocampus is an area of the brain commonly linked with memory and dementia. But new U of T Scarborough research finds that it may also yield important clues about a range of mental health illnesses including addiction, anxiety and depression. The research, authored by a team of neuroscientists...

Lack of sleep may be linked to risk factor for Alzheimer's disease

Tue, 17 Apr 2018 07:00:08 +0200

Losing just one night of sleep led to an immediate increase in beta-amyloid, a protein in the brain associated with Alzheimer's disease, according to a small, new study by researchers at the National Institutes of Health. In Alzheimer's disease, beta-amyloid proteins clump together to form amyloid p...

'Tic-tac-toe'-themed MRI technology easy win for neurological disease researchers

Tue, 17 Apr 2018 07:00:07 +0200

The University of Pittsburgh houses a whole-body 7 Tesla magnetic resonance imager (7T MRI), one of the strongest human MRI devices in the world and a powerful imaging tool that allows researchers to gain a far better understanding of brain structure and function. Tamer Ibrahim, associate professor ...

New CEO at Specim Spectral Imaging

Mon, 16 Apr 2018 14:00:03 +0200

Specim is delighted to announce that Mr. Tapio Kallonen has been appointed Chief Executive Officer of the Company effective as of April 18th, 2018. He succeeds Dr. Georg Meissner, who has requested to leave his position after having led Specim successfully for over 4 years. Tapio Kallonen will join ...

PhoreMost and Plexxikon collaborate to identify novel drug targets

Mon, 16 Apr 2018 14:00:02 +0200

PhoreMost, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, announced it has signed a collaborative agreement with Plexxikon Inc., the small molecule structure-guided R&D centre of Daiichi Sankyo. Under the agreement, PhoreMost will apply its next-generatio...

Tailor drugs for new targets in cancer therapy

Mon, 16 Apr 2018 11:16:24 +0200

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex SF3B. Researchers led by Vlad Pena at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen have now succeeded for the first tim...

Non-coding RNA reveals its secrets

Mon, 16 Apr 2018 07:00:12 +0200

Scientists from the Schuman Lab at the Max Planck Institute for Brain Research have investigated the variety of structures and functions in non-coding parts of messenger RNA (mRNA) from brain cells. These untranslated regions (UTRs) are essential for regulating the stability and localization of mRNA...

'Scaffolding' method allows biochemists to see proteins in remarkable detail

Mon, 16 Apr 2018 07:00:06 +0200

UCLA biochemists have achieved a first in biology: viewing at near-atomic detail the smallest protein ever seen by the technique whose development won its creators the 2017 Nobel Prize in chemistry. That technique, called cryo-electron microscopy, enables scientists to see large biomolecules, such a...

Peptide-based biogenic dental product may cure cavities

Mon, 16 Apr 2018 07:00:02 +0200

Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities. "Remineralization guided by peptides is a healthy alternative to current dental health care," said lead author Mehmet Sarikaya, professor o...

analytica closes with record-breaking visitor attendance

Mon, 16 Apr 2018 07:00:00 +0200

The 26th analytica met with overwhelming interest. In the past four days, some 35,800 visitors from all over the world came to the competitive exhibition of the industry on the Munich fairgrounds. They all wanted to know: Where is the laboratory industry heading? At the leading international trade f...

Spikes of graphene can kill bacteria on implants

Mon, 16 Apr 2018 02:00:00 +0200

A tiny layer of graphene flakes becomes a deadly weapon and kills bacteria, stopping infections during procedures such as implant surgery. Operations for surgical implants, such as hip and knee replacements or dental implants, have increased in recent years. However, in such procedures, there is alw...

Night owls have higher risk of dying sooner

Fri, 13 Apr 2018 11:20:48 +0200

"Night owls" - people who like to stay up late and have trouble dragging themselves out of bed in the morning - have a higher risk of dying sooner than "larks," people who have a natural preference for going to bed early and rise with the sun, according to a new study from Northwestern Medicine and ...

GSK transfers rare disease gene therapy portfolio

Fri, 13 Apr 2018 07:00:09 +0200

GSK and Orchard Therapeutics announced a strategic agreement, under which GSK will transfer its portfolio of approved and investigational rare disease gene therapies to Orchard, securing the continued development of the programmes and access for patients. This acquisition strengthens Orchard’s posit...

Certain iron supplements may influence the development of colon cancer

Fri, 13 Apr 2018 07:00:07 +0200

Two common iron compounds increase the formation of a known biomarker for cancer, according to a new study of cancer cells from Chalmers University of Technology, Sweden. The two compounds, ferric citrate and ferric EDTA, are often used in dietary supplements and as a food additive respectively, in ...

Sanofi to invest €350 million in Canadian vaccine facility

Fri, 13 Apr 2018 07:00:06 +0200

Sanofi is investing €350 million (CAD $500 million) for the construction of a new state-of-the-art vaccine manufacturing facility at the Sanofi Pasteur Canadian headquarters in Toronto, Ontario. The investment bolsters the company’s Canadian operations and its commitment to advancing public health a...

Sensitive new assay detects hepatitis B infection in single liver cells and serum

Fri, 13 Apr 2018 07:00:02 +0200

Chronic hepatitis B virus (HBV) can progress to cirrhosis and hepatocellular carcinoma (HCC). A study describes a new HBV assay that offers advantages over currently used methods because it has the capability to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples...

PerkinElmer appoints Chief Financial Officer

Thu, 12 Apr 2018 07:00:33 +0200

PerkinElmer, Inc. announced the appointment of James M. Mock to senior vice president and chief financial officer (CFO), effective May 1, 2018. Andy Wilson, PerkinElmer’s current senior vice president and CFO, who previously announced his retirement from PerkinElmer, will remain with the Company as ...

Evotec forms collaboration with Petra Pharma on INDiGO platform

Thu, 12 Apr 2018 07:00:30 +0200

Evotec AG announced a strategic collaboration with Petra Pharma Corporation. Through the collaboration, Petra will access Evotec’s INDiGO platform to accelerate the development of its lead programme Petra-01, which is being developed for a range of oncological indications, through to the submission ...

New class of drugs could help tackle treatment-resistant cancers

Thu, 12 Apr 2018 07:00:29 +0200

Researchers have discovered a new class of drug that has the potential to help cancer patients who no longer respond to existing therapies. The drug may not become available to patients for a number of years yet, but researchers believe that if clinical trials are successful, it could be used to tac...

Medigene appoints new CMO/CDO

Wed, 11 Apr 2018 14:00:00 +0200

Medigene AG announcedthe appointment of Dr. Kai Pinkernell to the Executive Management Board of the Company as Chief Medical Officer (CMO) and Chief Development Officer (CDO). Dr. Pinkernell has been with Medigene as Senior Vice President and Chief Medical Officer (CMO) since February 2016. Prof. Do...

Tiny nanomachine successfully completes test drive

Wed, 11 Apr 2018 11:05:42 +0200

Together with colleagues from the USA, scientists from the University of Bonn and the research institute Caesar in Bonn have used nanostructures to construct a tiny machine that constitutes a rotatory motor and can move in a specific direction. The researchers used circular structures from DNA. Nano...

HIV Cell dysfunction discovery sheds light on how virus works

Wed, 11 Apr 2018 07:00:07 +0200

A team of chemical and biomedical engineers from the Cockrell School of Engineering at The University of Texas at Austin, in collaboration with researchers from the University of Pennsylvania, have discovered that HIV-infected patients experience a dysfunction in a certain type of immune cell: the f...

Biomarker helps identify 'window of opportunity' for cancer chemotherapy timing

Wed, 11 Apr 2018 07:00:06 +0200

Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics. Combination therapy using angiogenesis in...

Deciphering the 'mosaic' of the brain

Wed, 11 Apr 2018 07:00:05 +0200

Researchers from the University of Leicester have shed new light on how neurons in the brain communicate with one another. This could potentially help in our understanding of how and why a range of neurodegenerative diseases occur. The team, led by Dr Joern Steinert from the MRC Toxicology Unit at t...

DNA testing can rapidly solve Legionnaires' disease outbreaks

Wed, 11 Apr 2018 07:00:03 +0200

A DNA test method called polymerase chain reaction (PCR) allowed New York City health officials to identify the source of a Legionnaires' disease outbreak within hours of specimen collection and should be considered in all Legionnaires' outbreak investigations, researchers say in the April issue of ...

New view of the heartbeat

Tue, 10 Apr 2018 07:00:09 +0200

The human cardiac voltage-gated sodium channel (Nav1.5) plays a critical role in maintaining regular heartbeats. Mutations in Nav1.5 cause life-threatening heart rhythm disorders (arrhythmias). Nav1.5 is sensitive to the calcium-ion sensor protein calmodulin (CaM); however, the exact mechanism of ho...

Bacteria "brewing" tiny, high-energy carbon rings

Tue, 10 Apr 2018 07:00:07 +0200

Caltech scientists have created a strain of bacteria that can make small but energy-packed carbon rings that are useful starting materials for creating other chemicals and materials. These rings, which are otherwise particularly difficult to prepare, now can be "brewed" in much the same way as beer....

A greener and cheaper technique for biofuel production

Tue, 10 Apr 2018 07:00:06 +0200

A team of engineers from the National University of Singapore (NUS) recently discovered that a naturally occurring bacterium, Thermoanaerobacterium thermosaccharolyticum TG57, isolated from waste generated after harvesting mushrooms, is capable of directly converting cellulose, a plant-based materia...

Research offers clues for improved influenza vaccine design

Tue, 10 Apr 2018 07:00:02 +0200

Influenza vaccines that better target the influenza surface protein called neuraminidase (NA) could offer broad protection against various influenza virus strains and lessen the severity of illness, according to new researchl. Current seasonal influenza vaccines mainly target a different, more abund...

How pathogenic bacteria prepare a sticky adhesion protein

Tue, 10 Apr 2018 07:00:01 +0200

Researchers at Harvard Medical School, the University of California, San Francisco, and the University of Georgia have described how the protein that allows strep and staph bacteria to stick to human cells is prepared and packaged. The research could facilitate the development of new antibiotics. Al...