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Smart people have better connected brains

Fri, 24 Nov 2017 06:00:45 +0100

Differences in intelligence have so far mostly been attributed to differences in specific brain regions. However, are smart people’s brains also wired differently to those of less intelligent persons? A new study published by researchers from Goethe University Frankfurt (Germany) supports this assum...

Bacteria as pacemaker for the intestine

Fri, 24 Nov 2017 06:00:43 +0100

Spontaneous contractions of the digestive tract play an important role in almost all animals, and ensure healthy bowel functions. From simple invertebrates to humans, there are consistently similar patterns of movement, through which rhythmic contractions of the muscles facilitate the transport and ...

Antibiotics resistance: Researchers succeed to block genes of resistance

Fri, 24 Nov 2017 06:00:35 +0100

Antibiotics are commonly used around the world to cure diseases caused by bacteria. But as the World Health Organization and other international bodies have pointed out, the global increase of antibiotic resistance is a rapidly worsening problem. And since antibiotics are also an essential part of m...

Distinguish good and bad molecules

Fri, 24 Nov 2017 06:00:33 +0100

Insilico Medicine, a Baltimore-based next-generation artificial intelligence company specializing in the application of deep learning for drug discovery announced the launch of the first phase of the Chemistry.AI program. Chemistry.AI is a crowd-sourced platform for analyzing the brain's response of...

Potent parasite protein - New therapeutic options for inflammatory bowel conditions?

Fri, 24 Nov 2017 06:00:33 +0100

A single protein from a worm parasite may one day offer new therapeutic options for treating inflammatory bowel diseases like Crohn’s or Ulcerative Colitis, that avoid the potentially serious side effects of current immunosuppressant medications. The study demonstrates the discovery of a distinct ne...

Nanoparticles help with malaria diagnosis

Thu, 23 Nov 2017 11:00:22 +0100

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases. An early diagnosis is vital for the timely and right kind of therapy. There are five different types of parasites at the origin of the diseas...

Managing Antibiotics Not Enough to Reverse Resistance

Thu, 23 Nov 2017 06:00:32 +0100

Researchers have discovered that reducing the use of antibiotics will not be enough to reverse the growing prevalence of antibiotic resistance for some types of bacteria. Besides passing along the genes bestowing antibiotic resistance to their offspring, many bacteria can also swap genes amongst the...

Pieris Pharmaceuticals Appoints new Chairman of the Board of Directors

Thu, 23 Nov 2017 06:00:31 +0100

Pieris Pharmaceuticals, Inc. announced that James Geraghty has been appointed Chairman of the Board of Directors. Mr. Geraghty replaces Chau Q. Khuong, who is stepping down from the Board after helping guide Pieris through platform validation and partnerships to its transition into a fully-integrate...

The main switch

Thu, 23 Nov 2017 06:00:29 +0100

During differentiation of pluripotent stem cells to cardiomyocytes, the three-dimensional folding of the DNA reorganizes itself. This reorganization of the DNA architecture precedes and defines important epigenetic patterns. A team lead by private lecturer Dr. Ralf Gilsbach and Stephan Nothjunge, wh...

New details on aged brain, Alzheimer's and dementia revealed

Thu, 23 Nov 2017 06:00:27 +0100

In a comprehensive analysis of samples from 107 aged human brains, researchers at the Allen Institute for Brain Science, UW Medicine and Kaiser Permanente Washington Health Research Institute have discovered details that will help researchers better understand the biological bases for Alzheimer's di...

New X-ray spectroscopy explores hydrogen-generating catalyst

Thu, 23 Nov 2017 06:00:00 +0100

Using a newly developed technique, researchers from Japan, Germany and the U.S. have identified a key step in production of hydrogen gas by a bacterial enzyme. Understanding these reactions could be important in developing a clean-fuel economy powered by hydrogen. The team studied hydrogenases - enz...

Avantor Completes Acquisition of VWR

Wed, 22 Nov 2017 16:32:42 +0100

Avantor, Inc., a global supplier of ultra-high-purity materials for the life sciences and advanced technology industries, today announced the successful completion of its acquisition of VWR Corporation (NASDAQ: VWR), the leading global independent provider of product, supply chain, and service solut...

Pneumonia: Treatment with Vaccines instead of Antibiotics

Wed, 22 Nov 2017 06:00:14 +0100

A properly functioning immune system is key to resolve bacterial pneumonia. Researchers from the University Children’s Hospital Zurich and UZH working with an international team have now found that specific immune cells are crucial for recovery. The researchers’ work paves the way for developing new...

EMA to relocate to Amsterdam

Wed, 22 Nov 2017 06:00:13 +0100

The European Medicines Agency (EMA) will relocate to Amsterdam in the Netherlands. This decision was taken today by the EU 27 Member States in the margins of the General Affairs Council (Art.50). The Agency now has just over 16 months to prepare for the move and take up its operations in Amsterdam o...

Carefully crafted light pulses control neuron activity

Wed, 22 Nov 2017 06:00:05 +0100

Specially tailored, ultrafast pulses of light can trigger neurons to fire and could one day help patients with light-sensitive circadian or mood problems, according to a new study in mice at the University of Illinois. Chemists have used such carefully crafted light beams, called coherent control, t...

Revolutionary imaging technique uses CRISPR to map DNA mutations

Wed, 22 Nov 2017 06:00:01 +0100

A team of scientists led by Virginia Commonwealth University physicist Jason Reed, Ph.D., have developed new nanomapping technology that could transform the way disease-causing genetic mutations are diagnosed and discovered. Described in a study this novel approach uses high-speed atomic force micro...

Symcel secures €3.6 million Horizon 2020 Phase II grant

Tue, 21 Nov 2017 13:00:01 +0100

Symcel, the company behind the revolutionary cell-based assay tool for real-time cell metabolism measurements, calScreener™, has secured €3.572 million Horizon 2020 funding to support the company’s evaluation of improved combination testing of antibiotics against extensively drug-resistant bacteria ...

Clever use of mirrors boosts performance of light-sheet microscope

Tue, 21 Nov 2017 10:19:03 +0100

Using a simple "mirror trick" and not-so-simple computational analysis, scientists affiliated with the Marine Biological Laboratory (MBL) have considerably improved the speed, efficiency, and resolution of a light-sheet microscope, with broad applications for enhanced imaging of live cells and embry...

A protein indicating higher breast cancer mortality risk

Tue, 21 Nov 2017 06:00:23 +0100

With the support of the Austrian Science Fund FWF, oncologists found a biomarker for breast cancer having a poor prognosis and developed two viable methods to detect it in tissue samples. Breast cancer is the most frequent malignant tumour in women worldwide. In Austria, about 5,500 women develop it...

CrownBio Launches an Innovative Grant Program

Tue, 21 Nov 2017 06:00:21 +0100

Crown Bioscience, a wholly-owned subsidiary of Crown Bioscience International announces the launch of a grant program supporting oncology research scientists which provides funding for projects that show promise for scientific advancement of Patient Derived Xenograft (PDX) technology. Research Grant...

Unexpected finding solves 40-year old cytoskeleton mystery

Tue, 21 Nov 2017 06:00:20 +0100

Scientists have been searching for it for decades: the enzyme that cuts the amino acid tyrosine off an important part of the cell’s skeleton. Researchers of the Netherlands Cancer Institute have now identified this mystery player, which may be of vital importance to the understanding of cell functio...

Water world

Tue, 21 Nov 2017 06:00:10 +0100

Researchers at Washington University in St. Louis have traced the paths of three water channels in an ancient photosynthetic organism to provide the first comprehensive, experimental study of how that organism uses and regulates water to create energy. Photosynthesis is the chemical conversion of su...

Computer program finds new uses for old drugs

Mon, 20 Nov 2017 06:00:13 +0100

Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potent...

New imaging technique peers inside living cells

Mon, 20 Nov 2017 06:00:11 +0100

To undergo high-resolution imaging, cells often must be sliced and diced, dehydrated, painted with toxic stains, or embedded in resin. For cells, the result is certain death. But if researchers can only view the inner workings of dead cells, they're only seeing part of the story. They cannot monitor...

Scientists capture colliding organic nanoparticles on video for first time

Mon, 20 Nov 2017 06:00:09 +0100

A Northwestern University research team is the first to capture on video organic nanoparticles colliding and fusing together. This unprecedented view of "chemistry in motion" will aid Northwestern nanoscientists developing new drug delivery methods as well as demonstrate to researchers around the gl...

How to switch liver cancer cell growth from 2-D to 3-D structures

Fri, 17 Nov 2017 13:00:04 +0100

Paving the way for testing experimental drugs in more realistic environments, scientists at the National Institute of Standards and Technology (NIST) have discovered how to make tiny colonies of cells grow in useful new ways inside petri dishes. The research team's discoveries might help designers o...

How the immune system identifies invading bacteria

Fri, 17 Nov 2017 13:00:02 +0100

The body's homeland security unit is more thorough than any airport checkpoint. For the first time, scientists have witnessed a mouse immune system protein frisking a snippet of an invading bacterium. The inspection is far more extensive than researchers imagined: the immune system protein, similar ...

Combined resistance to multiple antibiotics: A growing problem in the EU

Fri, 17 Nov 2017 06:00:19 +0100

On the occasion of the 10th European Antibiotic Awareness Day, the European Centre for Disease Prevention and Control (ECDC) is releasing its latest EU-wide data on antibiotic resistance, as well as its guidance on prevention and control of carbapenem-resistant Enterobacteriaceae (CRE). In 2016, com...

Eurofins expands its presence in India

Fri, 17 Nov 2017 06:00:16 +0100

Eurofins Scientific announces that it has acquired Spectro Analytical Labs Ltd. (“Spectro”), an environment, analytical product testing and inspection company in India. The company has over 22 years of experience in quality testing and inspection-related services, and owns accreditations from the Na...

World-first Panama disease-resistant Cavendish bananas

Fri, 17 Nov 2017 06:00:06 +0100

Researchers from Queensland University of Technology in Brisbane, Australia, have designed genetically modified Cavendish bananas with resistance to the devastating soil-borne Panama disease. This disease is caused by the fungus Fusarium oxysporum f.sp. cubense Tropical race 4 (TR4) and also known a...

Manganese-based MRI contrast agent may be safer alternative to gadolinium-based agents

Fri, 17 Nov 2017 06:00:05 +0100

A team of Massachusetts General Hospital (MGH) researchers has developed a potential alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). In their report the team describes experiments showing in a primate model that the manganese-based agent Mn-PyC3A produce...

Kevlar-based artificial cartilage mimics the magic of the real thing

Fri, 17 Nov 2017 06:00:02 +0100

The unparalleled liquid strength of cartilage, which is about 80 percent water, withstands some of the toughest forces on our bodies. Synthetic materials couldn't match it -- until "Kevlartilage" was developed by researchers at the University of Michigan and Jiangnan University. "We know that we con...

Unlocking the secrets of Ebola

Fri, 17 Nov 2017 01:00:00 +0100

Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease. The results come from scientists at the Department of Energy's Pacific Northwest National Laboratory and their colleagues at the University of Wiscons...

Making mosquitoes self-destruct

Thu, 16 Nov 2017 10:33:27 +0100

Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to the mosquitoes' DNA. As proof of concept,...

Hummingbird Diagnostics and Saarland University Collaborate in Early Disease Detection Based on Molecular Markers

Thu, 16 Nov 2017 06:00:16 +0100

Hummingbird Diagnostics GmbH, specialized in early disease detection using molecular markers derived from blood, and Saarland University agreed on a comprehensive framework agreement regarding an expanded collaboration in the field of molecular diagnostics. The work aims at the validation of miRNA b...

Shape-shifting agent targets harmful bacteria in the stomach

Thu, 16 Nov 2017 06:00:06 +0100

A new shape-shifting polymer can target and kill Helicobacter pylori bacteria in the stomach without killing helpful bacteria in the gut. Such a treatment could improve the digestive health of billions of people worldwide who contract H. pylori infections. The antimicrobial agent morphs into a bacte...

A way to synthesize drugs from renewable precursors

Thu, 16 Nov 2017 06:00:04 +0100

The scientists of RUDN University together with their Russian colleagues have developed a new approach to the synthesis of benzofurans from cheap raw materials. Original furans can be produced from wastes of agriculture and wooworking industry, such as sawdust, cobs and other by-products of crop pro...

Molzym Automated Pathogen Enrichment and PCR Test Gets CE Mark for In Vitro Diagnostics

Wed, 15 Nov 2017 13:57:42 +0100

Molzym announces CE IVD marking of their robotic microbial DNA isolation and direct PCR test, Micro-Dx™, for routine pathogen diagnosis. With Micro-Dx™ Molzym introduces its latest development of products in line with SepsiTest™-UMD which was released in 2008. “By Molzym’s proprietary robotic DNA is...

A sensor for the most important human cancer gene

Wed, 15 Nov 2017 11:17:46 +0100

If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the TP53 gene, the most important human cancer gene. The alert goes on if the TP53 gene is mutated in cells. The molecular smoke detector works like a TP53...

Researchers fold a protein within a protein

Wed, 15 Nov 2017 10:17:55 +0100

A team from the NUS Yong Loo Lin School of Medicine (NUS Medicine) has invented a fundamentally new way of folding and protecting recombinant proteins. Sourced from the rapidly expanding field of synthetic biology, this protein-in-a-protein technology can improve functional protein yields by 100-fol...

Focus on Medical Device Regulation

Wed, 15 Nov 2017 06:00:14 +0100

The EU Medical Device Regulation heralds a new era for the medical technology sector: in future, any company wishing to bring medical devices to market must face the requirements of this new regulatory framework. This implies a sizeable challenge for the many small and medium-sized enterprises in Ge...

Biocatalysts are a bridge to greener, more powerful chemistry

Wed, 15 Nov 2017 06:00:00 +0100

New research from the University of Michigan Life Sciences Institute is building a bridge from nature's chemistry to greener, more efficient synthetic chemistry. Researchers in the lab of Alison Narayan analyzed biocatalysts evolved by nature for their effectiveness in a variety of synthetic chemica...

Research from poor countries deserves a fairer hearing

Tue, 14 Nov 2017 10:30:49 +0100

Academia could be overlooking new ideas from low income nations without realising it, suggests an Imperial College London researcher. Dr Matthew Harris, from Imperial’s School of Public Health and Institute of Global Health Innovation, discusses how unconscious bias could be keeping developed and de...

A lipid’s role in cell division

Tue, 14 Nov 2017 06:00:11 +0100

Proper cell division is a basic process critical to cell survival. A ring composed of actin filaments and myosin motor proteins pinches the cell apart, producing two daughter cells with equal amounts of cellular components. Kathleen Gould , Ph.D., and colleagues characterized how this powerful contr...

Fueling the future

Tue, 14 Nov 2017 06:00:05 +0100

Changing the way the nation generates and consumes energy is at the heart of a new NSF grant awarded to Arizona State University and Kevin Redding, professor in the School of Molecular Sciences and director of the Center for Bioenergy and Photosynthesis (CB&P). The goal of Redding and his research g...

Agilent Thought Leader Award Presented to Renowned Drug Discovery Researcher Professor

Mon, 13 Nov 2017 13:00:04 +0100

Agilent Technologies Inc. announced that Professor Jiandong Jiang has received an Agilent Thought Leader Award in support of his studies on cancer stem cells differentiation induced by natural products. "Cancer is a chronic disease generated by multiple factors. Our research is focused on the treatm...

Genetic engineering mechanism visualized

Mon, 13 Nov 2017 13:00:03 +0100

One of the techniques used in genetic engineering — the process of artificially modifying the genome of a living organism — involves the so-called CRISPR-Cas9 nuclease system.  Using this system, a cell’s DNA can be cut at a desired site, where genes can be deleted or added.  Selection of the site t...

Innovative genetic and cellular techniques help identify multiple disease targets

Mon, 13 Nov 2017 13:00:01 +0100

Research released highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction. The studies were presented at Neuroscience 2017, the annual meeting of the Societ...

Nanoshells could deliver more chemo with fewer side effects

Mon, 13 Nov 2017 10:10:11 +0100

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside cancer cells in laboratory cultures. The study employed gold nanoshells to...

Turning jellyfish from a nuisance to useful product

Mon, 13 Nov 2017 06:00:09 +0100

Global climate change and the human impact on marine ecosystems have led to dramatic decreases in the number of fish in the ocean. It has also had an unforseen side effect: because overfishing decreases the numbers of jellyfish competitors, their blooms are on the rise. The GoJelly project, coordina...