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ZEISS Opts for Continuity: CEO Kaschke confirmed until 2020

Wed, 26 Jul 2017 07:00:08 +0200

The Supervisory Board of Carl Zeiss AG has decided to continue the appointment of Dr. Michael Kaschke as President & CEO until 30 June 2020. Kaschke joined the ZEISS Group 25 years ago and has served on the Executive Board since 2000. He has been President & CEO of Carl Zeiss AG since 2011. The Supe...

New triggerable, tough hydrogels could make drug-releasing systems safer

Wed, 26 Jul 2017 07:00:04 +0200

Drug-releasing devices that reside in the stomach for extended periods of time make it easier for patients to receive their full course of treatment. Instead of having to take a pill every day for a long period of time, a drug-delivery vehicle that slowly releases individual doses of medication coul...

Zebrafish study reveals clues to healing spinal cord injuries

Wed, 26 Jul 2017 07:00:02 +0200

Fresh insights into how zebrafish repair their nerve connections could hold clues to new therapies for people with spinal cord injuries. Researchers have pinpointed key molecules that prompt damaged nerve fibres in the fish to regenerate themselves. The findings could pave the way for treatments tha...

Alternative antimicrobial compounds could come from wastewater

Tue, 25 Jul 2017 11:10:22 +0200

Municipal wastewater may become a key ally in the fight against antibiotic-resistant disease-causing bacteria and fungi, a new study at Stellenbosch University (SU) found. "Certain bacteria in municipal wastewater produce antimicrobial compounds or biosurfactants that can help prevent the growth of ...

EMA’s CHMP Issues Positive Opinion for Avelumab for the Treatment of Metastatic Merkel Cell Carcinoma

Tue, 25 Jul 2017 07:00:21 +0200

Merck and Pfizer Inc. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended the approval of avelumab (BAVENCIO®) as a monotherapy for the treatment of adult patients with metastatic Merkel cell carcinoma (mMCC), a rare and agg...

On the Path to Vitamin A in Rice

Tue, 25 Jul 2017 07:00:19 +0200

The lack of vitamin A in food is a major cause of health problems worldwide and can lead to blindness and even death. This is especially a problem in threshold or third-world countries, where children are likely to suffer from a lack of vitamin A or its precursor beta-carotene due to malnourishment....

Library of CRISPR targeting sequences increases power of the gene-editing method

Tue, 25 Jul 2017 07:00:11 +0200

CRISPR, the gene-editing technology that has taken biology by storm, is now more powerful than ever. Scientists have assembled a library of RNA sequences that can be used by researchers to direct the CRISPR-cas9 complex to cut DNA with exquisite, unprecedented precision. Among other advantages, the ...

Optimization for self-production may explain mysterious features of the ribosome

Tue, 25 Jul 2017 07:00:06 +0200

In a new study, a team led by Johan Paulsson, professor of systems biology at Harvard Medical School, mathematically demonstrated that ribosomes are precisely structured to produce additional ribosomes as quickly as possible, in order to support efficient cell growth and division. The study's theore...

Innate Reaction of Hematopoietic Stem Cells to Severe Infections

Mon, 24 Jul 2017 07:00:13 +0200

Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide – that is, without signals from growth factors. This direct production of defensive cells damages hematopoiesis in the long term, however, which...

Shooting the achilles heel of nervous system cancers

Mon, 24 Jul 2017 07:00:10 +0200

Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center devised a strategy to target cancer cells while sparing normal cells. This s...

Scientists seek to engineer chatter among cells

Mon, 24 Jul 2017 07:00:07 +0200

Communities of cells communicate to coordinate their actions, but how do they coordinate with other communities? Scientists at Rice University and the University of Houston are preparing to find out. Rice synthetic biologist Matthew Bennett and University of Houston mathematician Krešimir Josić are ...

Merck and Pfizer Collaborate with Corning to Modernize Pharmaceutical Glass Packaging

Fri, 21 Jul 2017 14:00:03 +0200

Merck & Co., Pfizer and Corning Incorporated announced collaborations that have enabled the modernization of pharmaceutical packaging with the introduction of Corning Valor™ Glass. This revolutionary pharmaceutical glass packaging solution enhances the storage and delivery of today’s drug formulatio...

New hopes for therapy of chronic fatigue

Fri, 21 Jul 2017 14:00:02 +0200

Most people aren’t worn out by simple daily tasks requiring little exertion. But those with chronic fatigue syndrome might be exhausted by a walk across the room. A study by University of Florida Health researchers published recently in the Journal of Pain Research provides a possible explanation fo...

Recipharm and LIDDS establish industrial manufacturing capabilities

Fri, 21 Jul 2017 07:00:21 +0200

Recipharm and LIDDS have together set up a manufacturing line for LIDDS’ novel prostate cancer drug, Liproca®Depot, at Recipharm in Solna, Sweden. The manufacturing line is dedicated to the first product based on LIDDS’ innovative NanoZolid®technology. Clinical trial material has already been produc...

Macrophages engulf cancer cells in solid tumors

Fri, 21 Jul 2017 07:00:14 +0200

One reason cancer is so difficult to treat is that it avoids detection by the body. Agents of the immune system are constantly checking the surfaces of cells for chemical signals that say they belong, but cancer cells express the same chemical signals as healthy ones. Without a way for the immune sy...

Antibiotic insight may help in battle against bacterial resistance

Fri, 21 Jul 2017 07:00:03 +0200

Bacteria or 'superbugs' that have adapted to resist multiple antibiotics are responsible for around 700,000 deaths globally a year; new types of antibiotics are urgently needed. Monash University researchers, as part of an international collaboration, have identified a key part of the process by whi...

Silk 'micrococoons' could be used in biotechnology and medicine

Thu, 20 Jul 2017 14:00:02 +0200

Microscopic versions of the cocoons spun by silkworms have been manufactured by a team of researchers. The tiny capsules, which are invisible to the naked eye, can protect sensitive molecular materials, and could prove a significant technology in areas including food science, biotechnology and medic...

Why do BRCA1 mutations cause predominantly breast and ovarian cancer?

Thu, 20 Jul 2017 14:00:01 +0200

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also have up to a 39 percent chance to develop ovarian cancer. Rong Li, Ph.D., and colleagues at The Uni...

Acrylonitrile from renewable raw materials

Thu, 20 Jul 2017 11:03:44 +0200

Biocatalytic produced acrylonitrile is of great industrial interest to the "CO2 footprint" of polyacrylonitrile (PAN) fiber production. To address this, the main component for the production of PAN fibers, acrylonitrile, will be completely synthesized from renewable resources. The objective of this ...

Lunatic fringe gene plays key role in the renewable brain

Thu, 20 Jul 2017 07:00:10 +0200

The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated. Researchers at Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital have developed a...

Titanium dioxide nanoparticles can exacerbate colitis

Thu, 20 Jul 2017 07:00:05 +0200

Titanium dioxide, one of the most-produced nanoparticles worldwide, is being used increasingly in foodstuffs. When intestinal cells absorb titanium dioxide particles, this leads to increased inflammation and damage to the intestinal mucosa in mice with colitis. Researchers at the University of Zuric...

Brains are more plastic than we thought

Thu, 20 Jul 2017 07:00:04 +0200

Practice might not always make perfect, but it's essential for learning a sport or a musical instrument. It's also the basis of brain training, an approach that holds potential as a non-invasive therapy to overcome disabilities caused by neurological disease or trauma. Research at the Montreal Neuro...

A fresh role for nitric oxide

Thu, 20 Jul 2017 07:00:03 +0200

Cornell University chemists have uncovered a fresh role for nitric oxide that could send biochemical textbooks back for revision. They have identified a critical step in the nitrification process, which is partly responsible for agricultural emissions of harmful nitrous oxide and its chemical cousin...

Indestructible virus yields secret to creating incredibly durable materials

Thu, 20 Jul 2017 07:00:00 +0200

It's like the Superman of viruses, astonishingly tough and able to survive in an environment that would dissolve flesh and bone. And now scientists have unlocked the secrets of its indestructibility, potentially allowing them to harness its remarkable properties to create super-durable materials and...

New bacterial defense mechanism of the CRISPR-Cas system uncovered

Wed, 19 Jul 2017 07:00:12 +0200

Researchers led by Martin Jinek of the University of Zurich have found an unprecedented defense mechanism by which bacteria defend themselves against invading viruses. When the bacterial immune system gets overwhelmed, the CRISPR-Cas system produces a chemical signal that activates a second enzyme w...

Using omega 3 fatty acids to treat Alzheimer's & other diseases?

Wed, 19 Jul 2017 07:00:02 +0200

Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases. The key is to be able to intervene during the...

Antibiotic-releasing polymer may help eradicate joint implant infection

Wed, 19 Jul 2017 07:00:00 +0200

A team of Massachusetts General Hospital (MGH) investigators has developed an antibiotic-releasing polymer that may greatly simplify the treatment of prosthetic joint infection. In their recent report the researchers describe how implants made from this material successfully eliminated two types of ...

A new ligand extends the half-life of peptide drugs from minutes to days

Tue, 18 Jul 2017 12:37:34 +0200

Peptides are biological molecules, made up of short sequences of amino acids. Because they are easy to synthesize, show low toxicity and high efficiency, peptides such as insulin and other hormones can be used as drugs. But peptides are quickly cleared by the kidneys, which means that we can only us...

Personalize your medication dosages

Tue, 18 Jul 2017 12:37:32 +0200

Personalized drug therapy, adjusting the dose, dosage intervals, and the duration of treatment to fit individual patients' needs, are getting more and more important. Frequently, medications are dosed in such a way that each patient receives the same standardized amount of a certain drug. Thereby, c...

Max Planck Society grants technology for cancer therapy

Tue, 18 Jul 2017 07:00:36 +0200

Daiichi Sankyo, Max Planck Innovation, and the Lead Discovery Center have signed an agreement providing Daiichi Sankyo with the option to receive the exclusive rights to a new lead compound for the treatment of cancer to be discovered and developed at the Lead Discovery Center. This new partnership ...

Agent clears toxic proteins and improves cognition in neurodegeneration models

Tue, 18 Jul 2017 07:00:01 +0200

Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance. These dual findings, ...

Advance furthers stem cells for use in drug discovery, cell therapy

Mon, 17 Jul 2017 07:00:06 +0200

Since highly versatile human stem cells were discovered at the University of Wisconsin-Madison nearly 20 years ago, their path to the market and clinic has been slowed by a range of complications. Both embryonic stem cells and induced pluripotent stem cells are valued for their ability to form any c...

Potential cause for lupus identified

Mon, 17 Jul 2017 07:00:03 +0200

Leading rheumatologist and Feinstein Institute for Medical Research Professor Betty Diamond, MD, may have identified a protein as a cause for the adverse reaction of the immune system in patients suffering from lupus. A better understanding of how the immune system becomes overactive will help lead ...

Peptide complex formed in the brain is responsible for Alzheimer's disease

Mon, 17 Jul 2017 07:00:00 +0200

Members of the Faculty of Fundamental Medicine at the Lomonosov Moscow State University have determined the structure of a peptide complex, formed in the brain at the early stages of Alzheimer's disease progression. The research results will contribute to the rational design of compounds, capable to...

RNA Molecules Live Short Lives

Fri, 14 Jul 2017 07:00:08 +0200

A research group at the Biozentrum, University of Basel, has developed a new method to measure the half-life of RNA molecules. The study revealed that commonly used methods provide distorted results and that RNA molecules live an average of only two minutes, ten times shorter than previously assumed...

FDA advisory committee recommends first-ever CAR-T gene therapy treatment for cancer

Fri, 14 Jul 2017 07:00:06 +0200

Today the FDA's Oncologic Drugs Advisory Committee, an independent panel of experts, voted unanimously to recommend to the FDA approval of Novartis' experimental CAR-T therapy called Tisagenlecleucel, also known as CTL019. This form of gene therapy has demonstrated impressive results in hard-to-trea...

Illuminating the field of microscopy with nanoparticle 'buckyswitch'

Fri, 14 Jul 2017 07:00:05 +0200

Visualizing biological cells under a microscope was just made clearer, thanks to research conducted by graduate student Yifei Jiang and principal investigator Jason McNeill of Clemson University's department of chemistry. With the help of Rhonda Powell and Terri Bruce of Clemson's Light Imaging Faci...

Collagen controlling the thickness and juvenile state of skin

Thu, 13 Jul 2017 07:00:16 +0200

Type XVII collagen (COL17) is found to regulate the proliferation of epidermal cells and therefore the thickness of juvenile and aged skin, suggesting COL17 can potentially be used for future anti-aging strategies. Skin is the body's largest organ and is constantly confronted with a range of externa...

Merck Refines Western European Life Science Production Site Network

Thu, 13 Jul 2017 07:00:10 +0200

Merck announced the next phase in its continued efforts to drive operational excellence and improve efficiency of its Life Science business. The current site network in Western Europe will be refined, while the company invests € 90 million in four sites in Germany, Switzerland and France. Since 2010...

Everyday chemicals linked to chronic disease in men

Thu, 13 Jul 2017 07:00:08 +0200

Chemicals found in everyday plastics materials are linked to cardiovascular disease, type-2 diabetes and high blood pressure in men, according to Australian researchers. Researchers from the University of Adelaide and the South Australian Health and Medical Research Institute (SAHMRI) investigated t...

The fork in the road to DNA repair

Thu, 13 Jul 2017 07:00:06 +0200

The human body consists of trillions of cells, and within each are billions of DNA molecules. Strict maintenance of the molecules is essential to maintain a healthy cell and thus a healthy body. This maintenance is challenged by the daily bombardment of chemicals, UV light, radical oxgen and radiati...

Sanofi to acquire Protein Sciences

Wed, 12 Jul 2017 07:00:13 +0200

Sanofi announced it will acquire Protein Sciences, a privately held vaccines biotechnology company based in Meriden, Connecticut in the United States. Under the terms of the agreement, Sanofi will make an upfront payment of $650 million and pay up to $100 million upon achievement of certain mileston...

Accessing DNA in the cell's powerhouse to treat disease

Wed, 12 Jul 2017 07:00:08 +0200

For the first time, a synthetic compound has been made that can bind to DNA in the cells' energy powerhouses, suppressing a gene associated with nerve and muscle disease. Pyrrole-imidazole polyamides (PIPs) are compounds that can read specific DNA sequences inside living cells and silence disease-ca...

Manipulating cells could help treat Parkinson's, arthritis, other diseases

Wed, 12 Jul 2017 07:00:05 +0200

A groundbreaking advancement in materials from Northwestern University could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson's disease, Alzheimer's disease, arthritic joints or any other condition requiring tissue regeneration, according to a new s...

Enterome and Nestlé Health Science launch new diagnostics company

Tue, 11 Jul 2017 14:00:00 +0200

ENTEROME SA and Nestlé Health Science, announce the joint creation of Microbiome Diagnostics Partners (MDP). This company will bring together complementary, world-leading platforms and capabilities enabling the discovery and development of innovative diagnostics through to commercialization in multi...

Chronically ill, yet healthier

Tue, 11 Jul 2017 10:38:54 +0200

The incidence of chronic inflammatory lung diseases is on the rise throughout the world. According to the World Health Organization (WHO), they will become the third leading cause of death worldwide by 2030. So far, there is no reliable therapy, which only reflects the fact that the underlying mecha...

Tumor-targeting MRI contrast based on human protein

Tue, 11 Jul 2017 07:00:16 +0200

A team led by Gang Han, PhD, has designed a human protein-based, tumor-targeting Magnetic Resonance Imaging (MRI) contrast that can be easily cleared by the body. The discovery holds promise for clinical application, including early stage tumor detection because of the enhanced MRI contrast, accordi...

New research offers hope to neuro-tumor patients

Tue, 11 Jul 2017 07:00:15 +0200

New research published in the journal Oncogene could offer hope to the thousands of, mainly young, people affected by the hereditary condition Neurofibromatosis 2 (NF2). This condition is characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ...

A Biophysical ‘Smoking Gun’

Tue, 11 Jul 2017 07:00:12 +0200

While much about Alzheimer’s disease remains a mystery, scientists do know that part of the disease’s progression involves a normal protein called tau, aggregating to form ropelike inclusions within brain cells that eventually strangle the neurons. Yet how this protein transitions from its soluble l...

New cancer treatments linked to cardiovascular alterations

Tue, 11 Jul 2017 07:00:02 +0200

Plk1 inhibitors have recently been acknowledged as an "Innovative Therapy for leukaemia" by the US Food and Drug Administration (FDA). However, a study by researchers from the Spanish National Cancer Research Centre (CNIO) suggests that prolonged use of these inhibitors can not only lead to hyperten...