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Grand challenge for innovation in global vaccine manufacturing

Wed, 22 Feb 2017 13:00:05 +0100

Vaccines are among the most transformative and successful outcomes of modern medicine. For countries fortunate enough to have immunization coverage, their value can also lower or avert healthcare costs, increase economic productivity, and reduce poverty. The cost of producing and distributing vaccin...



Resolutions of the Sartorius Supervisory Board

Wed, 22 Feb 2017 11:36:53 +0100

The Supervisory Board of Sartorius AG approved the Executive Board’s recommendation to submit a proposal to the Annual Shareholders’ Meeting on April 6, 2017, to raise dividends to 0.46 euros per preference share and to 0.45 per ordinary share. Prior-year dividends, adjusted by the stock split that ...



Recipharm completes strategic acquisition in India

Wed, 22 Feb 2017 06:00:18 +0100

Recipharm AB announces that it has now concluded the acquisition of Kemwell’s pharmaceutical businesses located in Bengaluru, India. The expands position in emerging markets significantly, taking sales in these markets to more than SEK 800 million, dominated by sales directly to the fast-growing pha...



Prospect for more effective treatment of nerve pain

Wed, 22 Feb 2017 06:00:16 +0100

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Trigeminal neuralgia is characterized by sharp, lancinating pain in the teeth or facial area. The standard treatment for this chronic nerve pain can cause burdening side effects. A novel substance inhibits the pain effectively and is well tolerated, as documented by the initial results of an interna...



Listeria may be serious miscarriage threat early in pregnancy

Wed, 22 Feb 2017 06:00:08 +0100

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Listeria, a common food-borne bacterium, may pose a greater risk of miscarriage in the early stages of pregnancy than appreciated, according to researchers at the University of Wisconsin-Madison School of Veterinary Medicine studying how pathogens affect fetal development and change the outcome of p...



MS treatment that 'resets' immune system may halt disease for at least 5 years

Wed, 22 Feb 2017 06:00:05 +0100

Multiple sclerosis (MS) affects around 100,000 people in the UK, and 2.3 million worldwide. The condition is caused by the immune system malfunctioning and mistakenly attacking nerves in the brain and spinal cord. This leads to a range of symptoms including fatigue, problems with arm and leg movemen...



Improving therapies for GI tumors

Wed, 22 Feb 2017 06:00:04 +0100

The signaling protein Aurora kinase A (AURKA) is overexpressed in several cancer types and has diverse oncogenic functions, making it an attractive druggable cancer target. Wael El-Rifai , M.D., Ph.D., and colleagues are exploring a role for AURKA in upper gastrointestinal cancers, which are charact...



In-mouse catalysis

Tue, 21 Feb 2017 10:08:05 +0100

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Address and deliver: A gold catalyst can be delivered to a target organ in a higher organism where it performs a chemical transformation visualized by bioimaging. This intriguing approach has been introduced by a Japanese team of scientists. It could make organometallic catalysis applicable for ther...



Big improvement to brain-computer interface

Tue, 21 Feb 2017 06:00:11 +0100

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When people suffer spinal cord injuries and lose mobility in their limbs, it's a neural signal processing problem. The brain can still send clear electrical impulses and the limbs can still receive them, but the signal gets lost in the damaged spinal cord. The Center for Sensorimotor Neural Engineer...



Seeing DNA 'blink'

Tue, 21 Feb 2017 06:00:09 +0100

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Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques. Vadim Backman and Hao Zhang, nanoscale imaging...



DNA computer brings 'intelligent drugs' a step closer

Tue, 21 Feb 2017 06:00:08 +0100

Researchers at Eindhoven University of Technology (TU/e) present a new method that should enable controlled drug delivery into the bloodstream using DNA computers. The team, led by biomedical engineer Maarten Merkx, describes how it has developed the first DNA computer capable of detecting several a...



Developing a catalytic conveyor belt

Mon, 20 Feb 2017 13:00:04 +0100

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Capitalizing on previous studies in self-powered chemo-mechanical movement, researchers at the University of Pittsburgh's Swanson School of Engineering and Penn State University's Department of Chemistry have developed a novel method of transporting particles that utilizes chemical reactions to driv...



Rare blood disease improves the defence against germs

Mon, 20 Feb 2017 06:00:13 +0100

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Patients afflicted by myeloproliferative neoplasia – a group of chronic malignant bone marrow diseases – bear a mutation in their haematopoietic stem cells. The mutation leads to the bone marrow producing too many blood cells, which thickens the blood. This can lead to blood clots or clogged blood v...



Breakthrough in fight against superbug: klebsiella pneumonia

Mon, 20 Feb 2017 06:00:09 +0100

Researchers at Queen’s University Belfast have discovered why a lethal superbug is so resistant to the last line antibiotic meaning potential treatments could now be developed to fight the killer infection. The research carried out by Professor Jose Bengoechea, Director at the Centre for Experimenta...



Cellular responses to bird flu vaccine uncovered

Mon, 20 Feb 2017 06:00:06 +0100

New research from Vanderbilt University eavesdrops on gene expression in human immune system cells before and after vaccination against bird flu. The study exposes cellular responses associated with a vaccine constituent called AS03, short for adjuvant system 03. Using massive computation, the inves...



Takeda Completes Acquisition of ARIAD Pharmaceuticals, Inc.

Mon, 20 Feb 2017 06:00:05 +0100

Takeda announced the completion of its acquisition of ARIAD Pharmaceuticals for $24.00 per share in cash. “We are very pleased to have completed the acquisition of ARIAD Pharmaceuticals. The addition of ARIAD’s innovative targeted therapies and research and development capabilities strengthens and d...



Antibiotics could be alternative to surgery as treatment for appendicitis

Fri, 17 Feb 2017 13:00:01 +0100

A study by researchers at the University of Southampton shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery. The condition, which causes the appendix -- a small organ attached to the large intestine -- to become inflamed due to ...



New, ultra-flexible probes form reliable, scar-free integration with the brain

Fri, 17 Feb 2017 10:19:15 +0100

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Engineering researchers at The University of Texas at Austin have designed ultra-flexible, nanoelectronic thread (NET) brain probes that can achieve more reliable long-term neural recording than existing probes and don't elicit scar formation when implanted. A team led by Chong Xie, an assistant pro...



Nanotechnology based gene editing to eradicate HIV brain reservoir in drug abusers

Fri, 17 Feb 2017 06:00:07 +0100

Opiate abuse is a significant risk factor for HIV infection, and in combination they can have a devastating effect on the brain. Scientists at FIU Herbert Wertheim College of Medicine (HWCOM) are studying new therapies that can short-circuit HIV infection and mitigate the damaging effects that opiat...



Researchers identify phosphorylation process vital to cancer growth

Fri, 17 Feb 2017 06:00:05 +0100

Scientists at VIB-KU Leuven have identified a new mechanism that impacts tumor growth. The typical lack of oxygen in tumors doesn't only stimulate proliferation, but also offsets the important role of the protein PHD2 as 'cancer cell killer'. A possible solution lies in blocking the enzyme PP2A/B55,...



Ebolaviruses need very few mutations to cause disease in new host species

Thu, 16 Feb 2017 13:00:05 +0100

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Kent researchers have identified how few mutations it can take for Ebolaviruses to adapt to affect previously resistant species. Ebola is one of the world's most virulent diseases, though rodent species such as guinea pigs, rats and mice are not normally susceptible to it. However, through repeated ...



Illuminating the contacts

Thu, 16 Feb 2017 13:00:02 +0100

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The development of super resolution microscopy has revolutionised how scientists view and understand the inner workings of the cell. Just as advances in satellite camera technology gave rise to highly detailed maps of the world, so too has super-resolution microscopy allowed researchers to build det...



New research shows that proteins are 'virtually' knotted

Thu, 16 Feb 2017 06:00:08 +0100

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Many of the processes essential to life involve proteins - long molecules which 'fold' into three-dimensional shapes allowing them to perform their biological role. Consisting of strings of amino acids, a folded protein molecule resembles a coiled, tangled piece of wire, which, as everyday experienc...



Tumor-targeting system uses cancer's own mechanisms to betray its location

Thu, 16 Feb 2017 06:00:07 +0100

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer. Led by Jianjun Cheng, ...



Lipid nanoparticles for gene therapy

Thu, 16 Feb 2017 06:00:05 +0100

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Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy. Until now, viral systems have been the most effective method for delivering genetic matter but they pose significant safety problems. "Non-viral vectors, including SLNs and NLCs...



A new contrast agent for MRI

Wed, 15 Feb 2017 13:00:11 +0100

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A new, specially coated iron oxide nanoparticle developed by a team at MIT and elsewhere could provide an alternative to conventional gadolinium-based contrast agents used for magnetic resonance imaging (MRI) procedures. In rare cases, the currently used gadolinium agents have been found to produce ...



New method to detect ultrasound with light

Wed, 15 Feb 2017 10:07:37 +0100

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A tiny, transparent device that can fit into a contact lens has a bright future, potentially helping a range of scientific endeavors from biomedicine to geology. Developed by Northwestern University scientists, the device, called the Micro-ring resonator detector, can determine the speed of the bloo...



Ubiquitous and influential

Wed, 15 Feb 2017 06:00:19 +0100

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Scientists at the University of Würzburg have generated new insights into the intricate molecular underpinnings of ubiquitin signaling. Their results may provide new avenues for cancer therapy. The small protein ubiquitin regulates a plethora of physiological and pathophysiological processes in the...



X-ray pulses reveal structure of viral cocoon

Wed, 15 Feb 2017 06:00:14 +0100

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An international team of scientists has used high-intensity X-ray pulses to determine the structure of the crystalline protein envelope of an insect virus. Their analysis reveals the fine details of the building blocks that make up the viral cocoon down to a scale of 0.2 nanometres (millionths of a ...



Plant-made hemophilia therapy shows promise

Wed, 15 Feb 2017 06:00:12 +0100

People with hemophilia require regular infusions of clotting factor to prevent them from experiencing uncontrolled bleeding. But a significant fraction develop antibodies against the clotting factor, essentially experiencing an allergic reaction to the very treatment that can prolong their lives. Re...



Manufacturers in the laboratory sector choose analytica

Wed, 15 Feb 2017 06:00:00 +0100

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More than a year before the fair, this much is certain: analytica 2018 is very popular among exhibitors. Some 14 months before the next exhibition is set to begin, more than 230 companies have already registered to participate in the International Trade Fair for Laboratory Technology, Analysis and B...



A nanofiber matrix for healing

Wed, 15 Feb 2017 01:00:00 +0100

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A new nanofiber-on-microfiber matrix could help produce more and better quality stem cells for disease treatment and regenerative therapies. A matrix made of gelatin nanofibers on a synthetic polymer microfiber mesh may provide a better way to culture large quantities of healthy human stem cells. De...



Tiny magnetic implant offers new drug delivery method

Tue, 14 Feb 2017 13:00:01 +0100

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University of British Columbia researchers have developed a magnetic drug implant--the first of its kind in Canada--that could offer an alternative for patients struggling with numerous pills or intravenous injections. The device, a silicone sponge with magnetic carbonyl iron particles wrapped in a ...



How to make a protein trap

Tue, 14 Feb 2017 10:05:18 +0100

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Once they can synthesise molecules of active natural substances, scientists will be able to harness nature’s medicine cabinet for the drugs of the future. By testing newly developed synthesising processes and catalysts, a project funded by the Austrian Science Fund FWF managed to produce the promisi...



'Anti-aging' hormone could unlock new treatments for kidney and heart disease

Tue, 14 Feb 2017 06:00:11 +0100

A new study by researchers at King's College London has found that patients with diabetes suffering from the early stages of kidney disease have a deficiency of the protective 'anti-ageing' hormone, Klotho. The study, published in Diabetologia, suggests that Klotho may play a significant role in the...



Plasmas promote protein introduction in plants

Tue, 14 Feb 2017 06:00:07 +0100

The introduction of organic matter, such as proteins, into living cells has multiple uses for basic scientific research and industrial techniques. For example, the behavior of cell components can be traced by introducing a protein that emits a fluorescent signal into the cell. While scientists have ...



Ipsen to acquire a portfolio of select consumer healthcare products from Sanofi

Mon, 13 Feb 2017 13:00:01 +0100

Ipsen announced that it has entered into a definitive agreement to acquire five consumer healthcare products in certain European territories from Sanofi. The most significant product is Prontalgine® , an analgesic for the treatment of moderate to severe pain, which has grown at double digit rates ov...



Study describes drug that could prevent infertility in cancer patients

Mon, 13 Feb 2017 13:00:00 +0100

A new study led by Brian Hermann, assistant professor of biology at The University of Texas at San Antonio (UTSA), shows promising evidence that a medication previously used to prevent infections in cancer patients can also keep them from becoming infertile. Losing fertility is a frequent problem am...



Industry cancer clinician Dr. Jarl Ulf Jungnelius announced to serve as NOXXON CMO

Mon, 13 Feb 2017 06:00:05 +0100

NOXXON Pharma announced that Jarl Ulf Jungnelius, M.D., Ph.D. will take over the role of Chief Medical Officer. Dr. Jungnelius, who is already familiar with the company’s programs in a consulting capacity, will now increase his involvement with NOXXON, allowing for a period of overlap with Dr. Matth...



Traffic Light in the Brain

Mon, 13 Feb 2017 06:00:03 +0100

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Whether the brain responds to an external stimulus or not depends significantly on the balance between areas of excitation and inhibition in the prefrontal cortex (PFC). Synaptic connections in the front of the cerebral cortex enable the brain to make a conscious decision on whether to react to a st...



Infection defense: call for support by the killer cells

Mon, 13 Feb 2017 06:00:01 +0100

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A few days after a viral infection, countless killer cells swarm out to track down and kill infected body cells. In this way, they are highly effective at preventing pathogens from being able to spread further. An international research team has now explained an important mechanism behind building t...



In-cell molecular sieve from protein crystal

Fri, 10 Feb 2017 13:00:13 +0100

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In nature, proteins are assembled into sophisticated and highly ordered structures, which enable them to execute numerous functions supporting different forms of life. The exquisite design of natural proteins prompted scientists to exploit it in synthetic biology to engineer molecules that can self-...



Silver ion-coated medical devices could fight MRSA while creating new bone

Fri, 10 Feb 2017 13:00:11 +0100

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Methicillin-resistant Staphylococcus aureus (MRSA) infections are caused by a type of staph bacteria that has become resistant to the antibiotics used to treat ordinary staph infections. The rise of MRSA infections is limiting the treatment options for physicians and surgeons. Now, an international ...



Study of complex genetic region finds hidden role of NCF1 in multiple autoimmune diseases

Fri, 10 Feb 2017 13:00:09 +0100

Investigators at the Medical University of South Carolina (MUSC) report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, a...



The origin of stem cells

Fri, 10 Feb 2017 13:00:06 +0100

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Freiburg plant biologist Prof. Dr. Thomas Laux and his research group have presented initial findings on how shoot stem cells in plants form during embryogenesis, the process of embryonic development. Pluripotent stem cells can develop into any type of cell in an organism. In contrast to animals, pl...



Direct radiolabeling of nanomaterials

Fri, 10 Feb 2017 13:00:00 +0100

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Positron emission tomography plays a pivotal role for monitoring the distribution and accumulation of radiolabeled nanomaterials in living subjects. The radioactive metals are usually connected to the nanomaterial through an anchor, a so-called chelator, but this chemical binding can be omitted if n...



'Corrective glass' for mass spectrometry imaging

Fri, 10 Feb 2017 10:15:18 +0100

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The chemical analysis of biological tissues with three-dimensional shapes has been a major problem so far. Researchers at the Max Planck Institute for Chemical Ecology in Jena, Germany, have now improved mass spectrometry imaging in such a way that the distribution of molecules can also be visualize...



Better scaffolds help scientists study cancer

Fri, 10 Feb 2017 06:00:08 +0100

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Testing treatments for bone cancer tumors may get easier with new enhancements to sophisticated support structures that mimic their biological environment, according to Rice University scientists. A team led by Rice bioengineer Antonios Mikos has enhanced its three-dimensional printed scaffold to se...



Sex, drugs, and rock and roll chemistry in the brain

Fri, 10 Feb 2017 06:00:07 +0100

The same brain-chemical system that mediates feelings of pleasure from sex, recreational drugs, and food is also critical to experiencing musical pleasure, according to a study by McGill University researchers. "This is the first demonstration that the brain's own opioids are directly involved in mu...



'Goldilocks' genes that tell the tale of human evolution hold clues to variety of diseases

Fri, 10 Feb 2017 06:00:06 +0100

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Geneticists from Trinity College Dublin have used our evolutionary history to shine light on a plethora of neurodevelopmental disorders and diseases. Their findings isolate a relatively short list of genes as candidates for many diverse conditions including autism spectrum disorders, schizophrenia, ...