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MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Transplant Surgery



Last Build Date: Mon, 28 Mar 2016 07:13:31 +0100

 



Late onset of de novo atypical hemolytic-uremic syndrome presented on a simultaneous pancreas and kidney transplant recipient successfully treated with eculizumab.

Sun, 27 Mar 2016 00:29:02 +0100

Authors: Juega-Mariño FJ, Sala N, López D, Cañas L, Bonet J, Lauzurica R PMID: 27012439 [PubMed - as supplied by publisher] (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)

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Utility of quantitative real time PCR in detection and monitoring of viral infections in post renal transplant recipients

Sat, 26 Mar 2016 23:00:00 +0100

Conclusion Renal transplant patients frequently develop one or more viral infections at a time. Regular monitoring with qRT-PCR and prompt antiviral therapy with reduction in immunosuppression may be an ideal approach for management of these patients. (Source: Indian Journal of Transplantation)



Simeprevir or telaprevir with peginterferon and ribavirin for recurrent hepatitis C after living‐donor liver transplantation: A Japanese multicenter experience

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionSimeprevir‐based triple therapy for recurrent hepatitis C after living‐donor liver transplantation resulted in a high SVR rate and good tolerability, especially in treatment‐naïve patients. (Source: Hepatology Research)



Gender Matches in Liver Transplant Allocation: Matched and Mismatched Male-Female Donor-Recipient Combinations; Long-term Follow-up of More Than 2000 Patients at a Single Center.

Sat, 26 Mar 2016 19:17:02 +0100

CONCLUSIONS: The impressive long-term graft survival benefit of male donor-female recipient versus female donor-male recipient and of male donor-female recipient versus matched groups (male-male, femalefemale) in liver transplant may be caused by significant differences in donor quality and recipient charac teristics and may not be related to sex itself. PMID: 27015533 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)



Hand-assisted Laparoscopic Nephrectomy in Living-donor Kidneys With Multiple Arteries: Experience of a Transplant Center.

Sat, 26 Mar 2016 19:17:02 +0100

CONCLUSIONS: We found no differences in kidney function between single and multiple artery kidneys, resulting in the conclusion that hand-assisted laparoscopic nephrectomy offers an effective option for kidney donors, including those with multiple arteries. PMID: 27015532 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)

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Gender Disparity in Living-Donor Kidney Transplant Among Minority Ethnic Groups.

Sat, 26 Mar 2016 19:17:02 +0100

CONCLUSIONS: Gender disparity exists in living-donor kidney transplant, with disparities more pronounced in some ethnic groups and among particular relationships. This finding requires targeted counseling and research to understand whether the cause is medical or sociocultural obstacles. PMID: 27015531 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)



Determining the Superior Technique for Living-donor Nephrectomy: the Laparoscopic Intraperitoneal Versus the Retroperitoneoscopic Approach.

Sat, 26 Mar 2016 19:17:02 +0100

CONCLUSIONS: From this review, a high degree of study heterogeneity was identified, suggesting an urgent need for consistency in reporting laparoscopic living-donor nephrectomy. Results of the meta-analyses may define a better technique for the future. The retroperitoneoscopic approach may be better than the laparoscopic intraperitoneal approach with fewer complications and fewer patients with delayed graft function. Further study of laparoscopic living-donor nephrectomy is recommended to define a standard and thus to minimize the surgical morbidities. PMID: 27015530 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)



Consequences of Recipient Obesity on Postoperative Outcomes in a Renal Transplant: A Systematic Review and Meta-Analysis.

Sat, 26 Mar 2016 19:17:02 +0100

CONCLUSIONS: Our meta-analysis clearly demonstrated greater risks for obese renal transplant recipients and poorer postoperative outcomes with obesity. We confidently recommend renal transplant candidates seek medically supervised weight loss before transplant. PMID: 27015529 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)

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Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature.

Sat, 26 Mar 2016 19:17:02 +0100

Authors: Cosarderelioglu C, Cosar AM, Gurakar M, Pustavoitau A, Russell SD, Dagher NN, Gurakar A Abstract Portopulmonary hypertension is one of the main pulmonary conditions affecting patients with liver disease and/or portal hypertension. Other conditions include hepatopulmonary syndrome and hepatic hydrothorax. Portopulmonary hypertension is caused by pulmonary vasoconstriction and increased pulmonary vascular resistance. It develops as a result of portal hypertension with or without liver disease and is associated with a higher morbidity and mortality. However, portopulmonary hypertension is usually asymptomatic; the most common symptoms are dyspnea, fatigue, and peripheral edema. All liver transplant candidates should be screened for potential portopulmonary hypertension becaus...



Are our cornea waiting lists dynamic enough?

Sat, 26 Mar 2016 08:22:20 +0100

Abstract The purpose of this study was to evaluate the dynamic reality of the corneal transplant (CT) waiting list and if the CT candidates are really eager to operation. We evaluated the response of consecutive 96 CT candidates to call for operation. The age, functional visual acuity, CT indication, waiting period, and the excuse of refusal for candidates that postponed the operation were also evaluated. The patients were classified into two groups according to the availability (Group 1, available; Group 2, unavailable). To find an available candidate for transplantation of 48 consecutive corneal tissues, 96 patients had to be called. The mean age of the patients was 57.49 ± 18.75. The mean age of Group 1 and Group 2 was 54.28 ± 18.12 (13–80) and 60.44 ± 19.01 (9–88...



Many Kidney Transplant Patients Land in ER Within 2 Years

Sat, 26 Mar 2016 04:16:47 +0100

Findings show need to coordinate care after organ transplant, researcher says Source: HealthDay Related MedlinePlus Pages: Emergency Medical Services, Health Disparities, Kidney Transplantation (Source: MedlinePlus Health News)



Failure of primary atovaquone prophylaxis for prevention of toxoplasmosis in hematopoietic cell transplant recipients

Fri, 25 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Transplant Infectious Disease)

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Massive hemorrhage due to external iliac artery laceration in kidney transplantation: A case report of an uncommon complication after CT guided drainage

Fri, 25 Mar 2016 23:00:00 +0100

We report a case of a 56-year-old male with a kidney transplantation and a symptomatic peritransplant deep fluid collection who underwent a computed tomography (CT) guided drainage. Nine days after the procedure the patient had to be submitted to the surgical removal of the renal graft due to a massive bleeding caused by the position of the pigtail catheter lying on the wall of the external iliac artery. (Source: Indian Journal of Transplantation)



Educational Interventions for Patients With CKD: A Systematic Review

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Well-designed, interactive, frequent, and multifaceted educational interventions that include both individual and group participation may improve knowledge, self-management, and patient outcomes. (Source: American Journal of Kidney Diseases)



[Chronic hepatothorax due to right diaphragmatic rupture: an anesthetic challenge in a rare case].

Fri, 25 Mar 2016 20:50:01 +0100

CONCLUSIONS: Hepatothorax is a rare condition and its repair may represent an anesthetic challenge. After liver replacement in the abdominal cavity during corrective surgery under general anesthesia complications may occur, particularly associated with pulmonary re-expansion. Effective teamwork and careful planning of surgery, between the surgical and anesthetic teams, are the key to success. PMID: 27005827 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)



Incentivizing Authorization for Deceased Organ Donation with Organ Allocation Priority: The First Five Years

Fri, 25 Mar 2016 20:34:11 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)



The 2 Near-Death Experiences That Changed Mark Bertolini Forever

Fri, 25 Mar 2016 20:28:35 +0100

Before Mark Bertolini became the chief executive of the country's biggest health insurer, before he was celebrated by business publications for being an "unconventional boss" who is "mindful of morality," before he overhauled his company to prioritize the wellness of his workers, he was a father watching his teenage son die. It was 2001, and Bertolini's son Eric, who was then 16, was diagnosed with a rare type of cancer. Bertolini, now the chief executive of Aetna, quit his job at insurance rival Cigna and moved into his son's hospital room in Boston to help manage his care. Eric made a full recovery two years later, but was struck by complications and needed a kidney transplant. Once again, Bertolini stepped in, donating one of his kidneys to his son. Those experiences, coupled with a sev...

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Therapy Modalities for Antibody Mediated Rejection in Renal Transplant Patients.

Fri, 25 Mar 2016 20:12:02 +0100

CONCLUSION: AMR leads to progressive loss of renal function and has low graft survival. More effective treatment alternatives are needed for this clinical issue. PMID: 27002854 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)



Liver transplantation for aHUS: still needed in the eculizumab era?

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Liver transplant may definitely cure aHUS and represents an option for patients with suboptimal response to eculizumab. (Source: Pediatric Nephrology)



Successful renal transplantation in a patient with cold agglutinin disease

Fri, 25 Mar 2016 11:25:38 +0100

Cold agglutinin disease is a rare cause of acute graft loss after renal transplantation. A 71‐year‐old female with end stage renal failure was diagnosed to have cold agglutinin disease when investigated for recurrent clotting of hemodialysis circuits. Kidney transplantation was a major challenge due to unavoidable exposure of the transplant kidney to cold temperatures. Large volume plasma exchange given pre‐transplant and infusion of warm saline prior to anastomosis resulted in successful renal transplantation with good graft function despite initial delayed graft function. This challenging case illustrates the complete removal of cold agglutinin antibodies with therapeutic large volume plasma exchange. J. Clin. Apheresis, 2016. © 2016 Wiley Periodicals, Inc. (Source: Journal of Cli...



Resolution of Hepatic Artery Thrombosis in 2 Pediatric Liver Transplant Patients

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Hepatic artery thrombosis (HAT) is a serious complication after liver transplantation. This is the first report of spontaneous resolution of HAT in pediatric liver transplant patients on low molecular weight heparin therapy. A total of 2 patients, a 26-month-old boy who presented with acute liver failure and required emergent liver transplantation and a 15-year-old boy with ulcerative colitis and autoimmune hepatitis-primary sclerosing cholangitis overlap underwent liver transplantation for progressive cirrhosis; both developed HAT during the postoperative period. They were both treated with low molecular weight heparin. Follow-up imaging for both patients showed resolution of HAT without evidence of collateral flow. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Tacrolimus Concentration/Dose Ratio is Associated with Renal Function After Liver Transplantation.

Fri, 25 Mar 2016 07:23:02 +0100

CONCLUSIONS In this study, the Tac metabolism rate appears to influence renal function after LTx, suggesting that a C/D ratio of <1.09 is associated with increased CNI nephrotoxicity in LTx recipients. PMID: 27003330 [PubMed - in process] (Source: Annals of Transplantation)

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Many Kidney Transplant Patients Land in ER Within 2 Years: Study

Fri, 25 Mar 2016 07:00:00 +0100

Title: Many Kidney Transplant Patients Land in ER Within 2 Years: StudyCategory: Health NewsCreated: 3/24/2016 12:00:00 AMLast Editorial Review: 3/25/2016 12:00:00 AM (Source: MedicineNet Digestion General)



Med Students: Exceptionally High Rates of Alcohol AbuseMed Students: Exceptionally High Rates of Alcohol Abuse

Thu, 24 Mar 2016 23:17:43 +0100

One third of medical school students meet criteria for alcohol abuse or dependence -- double the rate of their non-med student peers. Medscape Medical News (Source: Medscape Transplantation Headlines)



Many Kidney Transplant Patients Land in ER Within 2 Years: Study

Thu, 24 Mar 2016 23:00:00 +0100

Findings show need to coordinate care after organ transplant, researcher says (Source: U.S. News - Health)



High intrapatient variability of tacrolimus concentrations predicts accelerated progression of chronic histologic lesions in renal recipients

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)

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Antibody‐Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology

Thu, 24 Mar 2016 23:00:00 +0100

We have established a model of sensitization in nonhuman primates and tested two immunosuppressive regimens. Animals underwent fully mismatched skin transplantation, and donor‐specific antibody (DSA) response was monitored by flow cross‐match. Sensitized animals subsequently underwent kidney transplantation from their skin donor. Immunosuppression included tacrolimus, mycophenolate, and methylprednisolone. Three animals received basiliximab induction; compared with nonsensitized animals, they showed a shorter mean survival time (4.7 ± 3.1 vs. 187 ± 88 days). Six animals were treated with T cell depletion (anti‐CD4/CD8 mAbs), which prolonged survival (mean survival time 21.6 ± 19.0 days). All presensitized animals showed antibody‐mediated rejection (AMR). In two of three basilixi...



Epidemiology, Evolution, and Long‐Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern Spain

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionsAC without viral infections is the main indication for LT in southeastern Spain although its frequency has decreased in last decade. AC is a good indication for LT for its high survival rate and few posttransplant complications. Despite having a high percentage of pretransplant complications (ascites and encephalopathy) but does not appear to influence survivals being observed posttransplant survival rates above those expected. Conversely, viral infections in the patient with AC decrease patient survivals. The main future goals are design new strategies to detect, treat, and reduce AC frequency in our population and know alcoholic recidivism rate posttransplant in our population. This figure shows Kaplan–Meier patient's survival curves according to the main indications for li...



How should we manage early tricuspid valve regurgitation after heart transplantation?

Thu, 24 Mar 2016 23:00:00 +0100

Tricuspid valvular regurgitation (TVR) is the most frequent valvular pathology after heart transplantation (HTx), with a reported incidence ranging from 19% to 84% [1]. In our center, early TVR, defined as moderate to severe insufficiency at post transplant discharge, was observed in 23% of patients [2]. Although the clinical course of TVR is often assumed to be benign, the development of early TVR in our transplant population was associated with impaired survival [2]. We have, therefore, starting in 2010, adapted a more active approach with surgical intervention for patients who developed severe TVR early after HTx. (Source: International Journal of Cardiology)



HLA-DR13, DR15 are associated with short-term lung transplant outcomes

Thu, 24 Mar 2016 23:00:00 +0100

Lung transplantation outcomes are among the least favorable, with the majority of recipients eventually developing bronchiolitis obliterans syndrome (BOS) and subsequent graft failure. Presence of human leukocyte antigen (HLA)-DR antigens has been implicated in the pathogenesis of BOS and may play a role in these poor outcomes. (Source: Journal of Surgical Research)



Assessing the Therapeutic Potential of Lab‐Made Hepatocytes

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Hepatology)

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Epidemiology, Evolution, and Long-Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern Spain.

Thu, 24 Mar 2016 23:00:00 +0100

CONCLUSIONS: AC without viral infections is the main indication for LT in southeastern Spain although its frequency has decreased in last decade. AC is a good indication for LT for its high survival rate and few posttransplant complications. Despite having a high percentage of pretransplant complications (ascites and encephalopathy) but does not appear to influence survivals being observed posttransplant survival rates above those expected. Conversely, viral infections in the patient with AC decrease patient survivals. The main future goals are design new strategies to detect, treat, and reduce AC frequency in our population and know alcoholic recidivism rate posttransplant in our population. PMID: 27012317 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimen...



Isolation of Individual Cellular Components from Lung Tissues of Patients with Lymphangioleiomyomatosis.

Thu, 24 Mar 2016 23:00:00 +0100

Authors: Ando K, Fujino N, Mitani K, Ota C, Okada Y, Kondo T, Mizobuchi T, Kurihara M, Suzuki K, Hoshika Y, Ebana H, Kobayashi E, Takahashi K, Kubo H, Seyama K Abstract Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease entailing cystic destruction of the lungs and progressive respiratory failure. LAM lungs are histologically characterized by the proliferation of smooth muscle-like cells (LAM cells) and an abundance of lymphatic vessels. To elucidate the pathophysiologic processes of LAM, cell type-specific analyses are required. However, no method exists for isolating the individual types of cells in LAM lesions. Therefore, we established a fluorescence-activated cell sorting (FACS)-based method for the direct isolation of LAM cells and other various cellular components f...



Many Kidney Transplant Patients Land in ER Within 2 Years: Study

Thu, 24 Mar 2016 19:00:29 +0100

THURSDAY, March 24, 2016 -- More than half of kidney transplant recipients wind up in an emergency department within two years of their operation, a new study finds. The researchers looked at more than 10,500 kidney transplant patients in... (Source: Drugs.com - Daily MedNews)



[New right bundle branch block after heart transplant as sign of subclinical rejection].

Thu, 24 Mar 2016 11:01:02 +0100

Authors: Wdowczyk J, Dorniak K, Stopczyńska I, Gruchała M PMID: 27004545 [PubMed - in process] (Source: Kardiologia Polska)



Discussion

Thu, 24 Mar 2016 01:35:37 +0100

DR WILLIAM C CHAPMAN (St Louis, MO): In the current report from Drs Edwards, Ertel, Shah, and colleagues from the Cincinnati transplant team, they performed a 4-year analysis of more than 10,000 liver transplants, or 45% of all US transplants during this period, using the University HealthSystem Consortium (UHC) and the Scientific Registry of Transplant Recipients (SRTR) datasets, with direct patient linkage between the 2 sets. Importantly, they found that more than 29% of patients underwent reoperation within 90 days of their transplantation, and that reoperation was associated with worsened outcomes, including worsened 1-year mortality and significantly increased costs of the transplant procedure. (Source: Journal of the American College of Surgeons)

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Safety and efficacy of sofosbuvir‐containing regimens in hepatitis C‐infected patients with impaired renal function

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionsSustained viral clearance was achieved in 83% of patients with renal impairment (eGFR ≤45 ml/min/1.73 m2) treated with SOF‐containing regimens. However, these patients had higher rates of anaemia, worsening renal dysfunction and serious adverse events regardless of use of RBV. Patient with renal impairment require close monitoring and should be treated by providers extensively experienced with SOF‐containing regimens. (Source: Liver International)



Liver transplant in ethylmalonic encephalopathy: a new treatment for an otherwise fatal disease

Wed, 23 Mar 2016 23:00:00 +0100

Ethylmalonic encephalopathy is a fatal, rapidly progressive mitochondrial disorder caused by ETHE1 mutations, whose peculiar clinical and biochemical features are due to the toxic accumulation of hydrogen sulphide and of its metabolites, including thiosulphate. In mice with ethylmalonic encephalopathy, liver-targeted adeno-associated virus-mediated ETHE1 gene transfer dramatically improved both clinical course and metabolic abnormalities. Reasoning that the same achievement could be accomplished by liver transplantation, we performed living donor-liver transplantation in an infant with ethylmalonic encephalopathy. Unlike the invariably progressive deterioration of the disease, 8 months after liver transplantation, we observed striking neurological improvement with remarkable achievements i...



The Canadian experience using the expanded criteria donor classification for allocating deceased donor kidneys for transplantation

Wed, 23 Mar 2016 23:00:00 +0100

Conclusions The ECD classification identifies kidneys at increased risk for graft loss in Canadian patients. The performance of more granular measures of donor risk (e.g., Kidney Donor Risk Index) and its impact on organ allocation/utilization in Canadian patients requires further study. (Source: Canadian Journal of Kidney Health and Disease)



Use of the Harmonic Scalpel in Cold Phase Recovery of the Pancreas for Transplantation: The Westmead Technique

Wed, 23 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Transplant International)



Optical aggregometry of red blood cells associated with the blood-clotting reaction in extracorporeal circulation support

Wed, 23 Mar 2016 23:00:00 +0100

Abstract The aggregability of red blood cell (RBCs) is associated with the contribution of plasma proteins, such as fibrinogen and lipoproteids, to blood-clotting. Hence, we hypothesized that RBC aggregability reflects the blood-clotting reaction. A noninvasive optical monitoring method to measure RBC aggregability for the assessment of blood-clotting stage during mechanical circulatory support was developed. An in vitro thrombogenic test was conducted with a rotary blood pump using heparinized fresh porcine blood. Near-infrared laser light at a wavelength of 785 nm was guided by an optical fiber. The fibers for detecting incident, forward-, and backward-scattered light were fixed on the circuit tubing with an inner diameter of 1/4 inch. Because there is substantial RBC aggregati...



Percutaneous drainage of splenic abscess in a renal transplant recipient – A case report

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Indian Journal of Transplantation Author(s): N.D. Srinivasaprasad, K. Manokaran, R. Vivekpraveen, M. Edwin Fernando Splenic abscess is a rare clinical entity with an incidence of 0.2–0.7% in autopsy-based studies. 1,2 Moreover, abscess of the spleen is a very rare entity in post-renal transplant recipients. We encountered a rare case of this life-threatening infection in a 32-year-old gentleman who had undergone live related renal transplant 8 months ago. He presented with fever, malaise, left upper quadrant pain and non-productive cough. Computed tomography (CT) of the chest taken to assess the lower chest signs and ultrasound abdomen taken to assess the left upper quadrant pain revealed a large thick walled abscess (8cm×7cm...



Emergency Department Visits after Kidney Transplantation.

Wed, 23 Mar 2016 23:00:00 +0100

CONCLUSIONS: The majority of kidney transplant recipients will visit an emergency department in the first 2 years post-transplantation, with significant variation by patient characteristics and individual centers. As such, coordination of care through the emergency department is a critical component of post-transplant management, and specific acumen of transplant-related care is needed among emergency department providers. Additional research assessing best processes of care for post-transplant management and health care expenditures and outcomes associated with emergency department visits for transplant recipients are warranted. PMID: 27012951 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)



Compensating living donors could 'help ease shortage of organs for transplant'

Wed, 23 Mar 2016 22:32:07 +0100

University of Florida scientists revealed 59 per cent of people are willing to donate a kidney for money. Experts say it could help some of the patients on the kidney transplant waiting list. (Source: the Mail online | Health)



Would YOU donate a kidney for $50,000? Compensating living donors could 'help ease severe shortage of organs for transplant'

Wed, 23 Mar 2016 22:01:25 +0100

University of Florida scientists revealed 59 per cent of people are willing to donate a kidney for money. Experts say it could help some of the patients on the kidney transplant waiting list. (Source: the Mail online | Health)

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What would happen if Americans were paid to donate their kidneys?

Wed, 23 Mar 2016 20:54:31 +0100

One of the strictest tenets of the U.S. transplant system is that paying for organs is forbidden. The ban, imposed by the National Transplant Act of 1984, was designed to protect the poor from being taken advantage of by the wealthy. Impassioned supporters of the law argued that compensating people for body parts is exploitative and treats donors like subhumans, and the debate […] (Source: Washington Post: To Your Health)



What Lab-Grown Human Hearts Could Mean For The Donor Crisis

Wed, 23 Mar 2016 19:48:14 +0100

This study certainly provides a direction which may lead to such a future. ... From this, we can identify that developing newer biomaterials would greatly enhance the viability of the approach, and needs further investigation." Related Coverage: How 3D Printing Could End The Deadly Shortage Of Donor Organs -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)



Acute kidney injury following liver transplantation: a systematic review of published predictive models

Wed, 23 Mar 2016 18:44:09 +0100

Acute kidney injury is a frequent postoperative complication amongst liver transplant recipients and is associated with increased morbidity and mortality. This systematic review analysed the existing predictive models, in order to solidify current understanding. Articles were selected for inclusion if they described the primary development of a clinical prediction model (either an algorithm or risk score) to predict AKI post liver transplantation. The database search yielded a total of seven studies describing the primary development of a prediction model or risk score for the development of AKI following liver transplantation. The models span thirteen years of clinical research and highlight a gradual change in the definitions of AKI, emphasising the need to employ standardised definition...



Paying for Kidneys Might Boost Donor Rate

Wed, 23 Mar 2016 18:20:46 +0100

But transplant experts say it's an ethically loaded idea that needs much review (Source: WebMD Health)

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Paying for Kidneys Might Boost Donor Rate, Study Says

Wed, 23 Mar 2016 16:00:00 +0100

But transplant experts say it's an ethically loaded idea that needs much review (Source: U.S. News - Health)



Single-center study on transplantation of livers donated after cardiac death: A report of 6 cases.

Wed, 23 Mar 2016 14:45:02 +0100

Authors: Sun XY, Dong JH, Qin KE, Lan LG, Li HB, Huang Y, Cao S, Li ZJ, Dai LJ Abstract Effective use of all available donated organs is critical, in order to meet the increasing demand for transplants. The present study explored liver transplantation with livers that were donated following cardiac death (DCD). According to the guidelines established by The Red Cross Society of China, 42 DCD organs were procured. Selected donors were treated with extracorporeal membrane oxygenation (ECMO) prior to the organ retrieval. The present single-center study included 6 liver transplantations of DCD organs (5 liver transplants and 1 liver-kidney combined transplant). All 6 recipients had a successful recovery without significant complications. The serum alanine transaminase, total bilirubin ...



Vascular Access Type and Patient and Technique Survival in Home Hemodialysis Patients: The Canadian Organ Replacement Register.

Wed, 23 Mar 2016 13:28:13 +0100

This registry-based retrospective observational cohort study assessed 1217 incident HHD patients in The Canadian Organ Replacement Register who had information for vascular access type (CVC vs AV access) within the first year of HHD therapy initiation.  The results showed that AV access use (n=694) was associated with lower risk for the composite event of death and technique failure (490 events; adjusted HR, 0.78; 95% CI, 0.64-0.94) and lower adjusted all-cause mortality (129 deaths; adjusted HR, 0.63; 95% CI, 0.43-0.91) while the risk for technique failure was not statistically significant.   : Peritoneal Equilibration Test and Patient Outcomes. Asymmetrical Dimethylarginine Is Associated with Renal and Cardiovascular Outcomes and All-cause Mortality in Renal Trans...



Unlocking the Potential of Purinergic Signaling in Transplantation

Wed, 23 Mar 2016 11:34:08 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)

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[Renewed 2015 Clinical Practice Guidelines for Management of Hepatitis C by Korean Association for the Study of the Liver; What Has Been Changed? - Indications for Treatment].

Wed, 23 Mar 2016 02:44:03 +0100

Authors: Kim KA Abstract The landscape of treatment for HCV infection has evolved substantially with the advent of highly effective direct-acting antiviral agents (DAA). The Korean Association for the Study of the Liver updated guideline for managemnt of hepatitis C in accordance with the introduction of DAA into practice in late 2015. Due to high effectiveness and few side effects of DAA, indications for treatment has been widened to include patients who had been contraindicated for the combination treatment of peginterferon-α and ribavirin, i.e. decompensated cirrhosis and pre- and post-liver transplant setting. As succeesul treatment of HCV can reduce complications of cirrhosis, development of hepatocelluar carcinoma and liver-related mortality, and improve extrahepatic manifes...



Analysis of Risk Factors for Abnormal Pulmonary Function in Pediatric Cancer Survivors

Wed, 23 Mar 2016 00:14:02 +0100

ConclusionsAlmost two‐thirds of survivors screened per the COG‐LTFU Guidelines had an abnormal PFT but a majority reported no clinical symptoms. Hyperinflation was the most prevalent abnormality. (Source: Pediatric Blood and Cancer)



Survival benefit from kidney transplantation using kidneys from deceased donors over 75 years – a time dependent analysis

Tue, 22 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)



Epidemiological Trends in NASH as a Cause for Liver Transplant

Tue, 22 Mar 2016 23:00:00 +0100

Abstract Nonalcoholic fatty liver disease (NAFLD), defined by excess hepatic fat accumulation, is closely linked to obesity and diabetes through changes in insulin sensitivity. Worldwide, obesity and diabetes prevalence rates are increasing, a consequence of modernisation of lifestyle, especially in Asia. Nonalcoholic steatohepatitis (NASH), histologically defined by the presence of hepatic inflammation and ballooning, is associated with an increased risk of morbidity and death, including from end-stage liver disease and primary liver cancer, especially in those with significant liver fibrosis. Based on data available, a large number of liver transplantation undertaken for hepatocellular cancer and end-stage liver disease, currently occur in the setting of chronic viral hepatitis....

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Onco-nephrology: a decalogue

Tue, 22 Mar 2016 23:00:00 +0100

Onco-nephrology is an evolving subspecialty that focuses on the complex relationships existing between kidney and cancer. In this opinion piece, we propose a ‘decalogue of onco-nephrology’, in order to highlight the areas where the nephrologist and oncologist should work closely over the ensuing years to provide cutting-edge care for patients afflicted with cancer and kidney disease. The 10 points we have highlighted include (1) acute kidney injury and chronic kidney disease in cancer patients; (2) nephrotoxic effects of anticancer therapy, either traditional chemotherapeutics or novel molecularly targeted agents; (3) paraneoplastic renal manifestations; (4) management of patients nephrectomized for a kidney cancer; (5) renal replacement therapy and active oncological treatment...



N-octanoyl dopamine treatment exerts renoprotective properties in acute kidney injury but not in renal allograft recipients

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions NOD treatment reduces renal injury in warm ischaemia, but is not effective in renal transplant in our experimental animal models. The salutary effect of NOD appears to be TPRV1-dependent, not involving large changes in renal perfusion. (Source: Nephrology Dialysis Transplantation)



Effect of assistance on peritonitis risk in diabetic patients treated by peritoneal dialysis: report from the French Language Peritoneal Dialysis Registry

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions In France, nurse-assisted PD is associated with a lower risk of peritonitis in diabetic patients treated by PD but not a lower incidence of peritonitis. (Source: Nephrology Dialysis Transplantation)



Pre-transplant donor-specific anti-human leukocyte antigen antibodies are associated with high risk of delayed graft function after renal transplantation

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions The risk of DGF is twice as high in patients having pre-formed DSAs. Pre-Tx DSAs is a modifiable risk factor that can be obviated with careful organ allocation relying on careful pre-Tx analysis of non-accepted mismatches determined with sensitive solid phase methods. (Source: Nephrology Dialysis Transplantation)



External iliac artery polytetrafluoroethylene graft interposition: An effective rescuer for kidney transplant in progressive intimal dissection of external iliac artery

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion: Polytetrafluoroethylene interposition graft is a successful procedure to salvage the kidney and lower limb in case of progressive intimal dissection of external iliac artery during renal transplant surgery. (Source: Urology Annals)

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Donor‐Specific HLA Antibodies in Living Versus Deceased Donor Liver Transplant Recipients

Tue, 22 Mar 2016 23:00:00 +0100

In conclusion, although similar in prevalence, DSA may have more impact in DDLT than LDLT recipients. Although our findings need further validation, future research should more robustly test the effect of donor type and strategies to mitigate the impact of DSA. (Source: American Journal of Transplantation)



Transplant Immunology, edited by Xian Li and Anthony Jevnikar. Hoboken, NJ: John Wiley & Sons, Ltd., 2016. 347 pages.

Tue, 22 Mar 2016 23:00:00 +0100

(Source: American Journal of Transplantation)



Human Alpha-1 Antitrypsin Improves Early Post-Transplant Lung Function: Pre-Clinical Studies in a Pig Lung Transplant Model

Tue, 22 Mar 2016 23:00:00 +0100

The translation of novel drugs in lung transplantation is challenged by different physiological conditions between small animals and humans. Large animal models provide important pre-clinical evidence and the next step that best informs clinical trials. In the present study, we used a pig lung transplant model to determine whether human alpha-1 antitrypsin (A1AT), a medication shown to prevent pulmonary ischemia-reperfusion injury in rats, could attenuate reperfusion injury after prolonged hypothermic preservation in a large animal lung transplant model. (Source: The Journal of Heart and Lung Transplantation)



A Rare Case of Aspergillus Pericarditis with Associated Myocardial Abscess and Echocardiographic Response to Therapy

Tue, 22 Mar 2016 23:00:00 +0100

We present a case of a patient with recent orthotopic liver transplant, on immunosuppression, who presented with cardiac tamponade due to Aspergillus fumigatus pericarditis and associated myocardial abscess. The diagnosis was made based on computed tomography imaging, culture of pericardial fluid for Aspergillus, and transthoracic echocardiography. The patient received antifungal therapy with clinical improvement and documented reduction in abscess size based on repeat echocardiogram. Aspergillus myocardial abscess is an extremely rare diagnosis but should be considered in an immunosuppressed patient presenting with pericardial effusion or ventricular mass. (Source: Echocardiography)



Retrospective analysis of perioperative transfusion requirements in living donor renal transplantation

Tue, 22 Mar 2016 23:00:00 +0100

Extensive bleeding in solid organ transplantation is a major challenge faced by transplant surgeons. Our aim was to audit the peri-operative transfusion requirements in our patients. (Source: Transfusion and Apheresis Science)



Care and outcomes of end-stage kidney disease patients in times of armed conflict: recommendations for action.

Tue, 22 Mar 2016 23:00:00 +0100

CONCLUSIONS: ESKD patients, especially dialysis patients, comprise a severely vulnerable population during conflicts. Their care can be disrupted and altered leading to a substantial increase in their mortality rate. Efforts to improve their care during conflicts are needed. PMID: 27007869 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)



Claudin 19-based familial hypomagnesemia with hypercalciuria and nephrocalcinosis in a sibling pair.

Tue, 22 Mar 2016 23:00:00 +0100

CONCLUSIONS: Although rare, FHHNC should be suspected in patients who present with nephrocalcinosis in the setting of congenital eye anomalies. PMID: 27007868 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)



Experimental Reconstruction of the Trachea with Urinary Bladder Wall.

Tue, 22 Mar 2016 23:00:00 +0100

CONCLUSIONS: Tracheal reconstruction using bladder wall may become clinically useful. A pedicled omental covering does not appear always necessary to prevent graft necrosis and infection. Ischemic stimulation may be involved with bone formation in grafts. PMID: 27009558 [PubMed - as supplied by publisher] (Source: Annals of Thoracic and Cardiovascular Surgery)

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Peritoneal Dialysis: From Bench to Bedside and Bedside to Bench.

Tue, 22 Mar 2016 23:00:00 +0100

Authors: Perl J, Bargman JM Abstract For patients with end-stage kidney disease unable to receive a kidney transplant, replacement of kidney function with dialysis is necessary. Peritoneal Dialysis (PD), and hemodialysis (HD) are the two major forms of dialysis therapy. HD involves the passage of blood via an extracorporeal circuit whereby removal of small solutes, toxins, and water is achieved across a synthetic, semipermeable dialysis membrane. In contrast, in PD, the dialysis membrane is the highly vascularized internal lining of the peritoneal cavity. Intraperitoneal installation of hypertonic high glucose PD solution creates a transmembrane osmotic and diffusive gradient that facilitates water removal (ultrafiltration), convection and diffusion of uremic toxins. Insight into t...



Special considerations for the use of lung transplantation in pediatrics.

Tue, 22 Mar 2016 19:21:02 +0100

Authors: Schmid FA, Benden C Abstract Lung transplantation has become an accepted therapy in infants, children and adolescents suffering from end-stage lung diseases, an impaired quality of life as well as a reduced life expectancy. Within Europe, pediatric lung transplantation is largely performed in predominantly adult centers due to a relatively low overall case volume. Children do represent a specific and challenging cohort facing a transplant procedure, where the selection of potential candidates becomes a crucial step to maximize net survival benefit. Therefore, interdisciplinary evaluation and early listing in view of current indications and contraindications, adequate preoperative education of the child and family members, discussion of possibly required bridging procedures...



Organ Transplantation in Nigeria

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



Research Highlights

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



A Novel Bioprosthetic Total Artificial Heart

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)

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Digital Learning in Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



BK Virus Infection After Kidney Transplantation: The Data Are Mounting for a Personalized Approach

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



Biomarkers of Transplant Tolerance: A Provisional Analysis for an Unmet Need

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



“Failure to Rescue” as a Novel Quality Metric in Pediatric Liver Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



Bringing Rationality to Rationing?—The Challenges of Organ Allocation

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)

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Qualitative Research in Transplantation: Ensuring Relevance and Rigor

Tue, 22 Mar 2016 16:43:21 +0100

No abstract available (Source: Transplantation)



Early Hospital Readmissions After Transplantation: Burden, Causes, and Consequences

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Early hospital readmission after transplantation is common and associated with adverse outcomes. The potential for preventing early hospital readmissions and the impact on patient outcomes remain unclear. Current evidence suggests that some, but not all, early hospital readmissions after transplantation may be prevented. (Source: Transplantation)



Hypercoagulability in Kidney Transplant Recipients

Tue, 22 Mar 2016 16:43:21 +0100

Abstract: Thrombosis remains an important complication after kidney transplantation. Outcomes for graft and deep vein thrombosis are not favorable. The majority of early kidney transplant failure in adults is due to allograft thrombosis. Risk stratification, early diagnosis, and appropriate intervention are critical to the management of thrombotic complications of transplant. In patients with end-stage renal disease, the prevalence of acquired risk factors for thrombosis is significantly high. Because of hereditary and acquired risk factors, renal transplant recipients manifest features of a chronic prothrombotic state. Identification of hereditary thrombotic risk factors before transplantation may be a useful tool for selecting appropriate candidates for thrombosis prophylaxis immediately...



Frailty and Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

Abstract: Consequences of aging are gaining clinical relevance. In transplantation, aging and immunosenescence impact treatment and outcomes. The impact of aging, however, will critically depend on distinguishing healthy, chronological aging from biological aging that may result into frailty. Approximately 15% of individuals older than 65 years are frail, and it is expected that this condition will gain more clinical relevance with an expected increase to greater than 20% over the next 5 years. Clearly, frailty impacts various general aspects of health care and organ transplantation in particular including patient selection, waitlist management and treatment after transplantation. In general, frailty has been characterized by a compromised physiological reserve and an augmented vulnerabili...



Cognitive Changes in Chronic Kidney Disease and After Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

Abstract: Cognitive impairment is very common in chronic kidney disease (CKD) and is strongly associated with increased mortality. This review article will discuss the pathophysiology of cognitive impairment in CKD, as well as the effect of dialysis and transplantation on cognitive function. In CKD, uremic toxins, hyperparathyroidism and Klotho deficiency lead to chronic inflammation, endothelial dysfunction and vascular calcifications. This results in an increased burden of cerebrovascular disease in CKD patients, who consistently have more white matter hyperintensities, microbleeds, microinfarctions and cerebral atrophy on magnetic resonance imaging scans. Hemodialysis, although beneficial in terms of uremic toxin clearance, also contributes to cognitive decline by causing rapid fluid an...



Attenuating Ischemia-Reperfusion Injury in Kidney Transplantation by Perfusing Donor Organs With siRNA Cocktail Solution

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: In conclusion, this is the first demonstration that perfusing donor organs with an siRNA cocktail solution can induce gene silencing in the kidney and prevent kidneys from extended cold I/R injury in kidney transplantation, highlighting the promise of the clinical application of siRNA-based therapies in the preservation of donor organs. (Source: Transplantation)



Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Recruitment of huTreg to porcine endothelium depends on particular chemokine receptors (CXCR3, CCR4) and integrins (CD18 and CD49d) and was increased by CCL17 coating. These results will help to develop new strategies to enhance the recruitment of host huTreg to xenogeneic grafts to regulate cell-mediated xenograft rejection including NK cell responses. (Source: Transplantation)



Donor-antigen Inoculation in the Testis Promotes Skin Allograft Acceptance Induced by Conventional Costimulatory Blockade via Induction of CD8 + CD122+ and CD4 + CD25+ Regulatory T Cells

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 + CD122+ and CD4 + CD25+ Treg cells. (Source: Transplantation)

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E-Selectin Mediates Immune Cell Trafficking in Corneal Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: In a model of corneal transplantation, P- and E-selectin mediate T cell recruitment to the graft, E-selectin mediates APC trafficking to lymphoid tissue, and blockade of E-selectin has a modest effect on improving long-term graft survival. (Source: Transplantation)



Liver microRNA Profile of Induced Allograft Tolerance

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: The miRNA profile of established tolerant allografts is very similar to syngeneic grafts, suggesting tolerance may be a return to an immunological state of quiescence. (Source: Transplantation)



Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Ischemia-reperfusion injury was associated with increased high-mobility group box 1, TLR4, and NOX2. Inhibition of NOX activity improved oxidative stress and may prevent I/R injury in fatty liver. (Source: Transplantation)



Failure to Rescue as a Quality Improvement Approach in Transplantation: A First Effort to Evaluate This Tool in Pediatric Liver Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Our results demonstrate that although centers with higher mortality and DCGL have more frequent major complications, they exhibit 3-fold the rate of FTR. Efforts to standardize perioperative care, and thus minimize FTR, will have value to pediatric liver transplantation recipients. This preliminary study indicates that FTR may provide a useful quality improvement tool for the field of transplantation and warrants further investigation. (Source: Transplantation)

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The Origin of New-Onset Diabetes After Liver Transplantation: Liver, Islets, or Gut?

Tue, 22 Mar 2016 16:43:21 +0100

Abstract: New-onset diabetes is a frequent complication after solid organ transplantation. Although a number of common factors are associated with the disease, including recipient age, body mass index, hepatitis C infection, and use of immunosuppressive drugs, new-onset diabetes after liver transplantation (NODALT) has the following unique aspects and thus needs to be considered its own entity. First, a liver graft becomes the patient's primary metabolic regulator after liver transplantation, but this would not be the case for kidney or other grafts. The metabolic states, as well as the genetics of the graft, play crucial roles in the development of NODALT. Second, dysfunction of the islets of Langerhans is common in cirrhotic patients and would be exacerbated by immunosuppressive agents, ...



Safety of Live Liver Donation by Individuals With G6PD Deficiency: Initial Results and Comparative Study

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: This is the first case series reporting the safety of liver resection in G6PDd individuals. Hepatectomy in G6PD-deficient donors is associated with a greater drop in postoperative hemoglobin and a marginally increased need for postoperative transfusion. Use of these donors can be considered with caution, and it should not be an absolute contraindication for live liver donation. (Source: Transplantation)



Prognostic Value of Preoperative Brain Natriuretic Peptide Serum Levels in Liver Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: In cirrhotic patients, pre-LT BNP serum level was an independent predictor of post-LT ICU mortality. With its excellent negative predictive value, the use of this biomarker in combination with MELD score could be useful to better predict post-LT early outcome. (Source: Transplantation)



Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Two hours of oxygenated HMP after traditional SCS restores hepatic ATP levels and improves hepatobiliary function but does not reduce (preexisting) hepatobiliary injury in ECD livers. (Source: Transplantation)

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An Update on Calcineurin Inhibitor–Free Regimens: The Need Persists, but the Landscape has Changed

Tue, 22 Mar 2016 16:43:21 +0100

Abstract: Calcineurin inhibitors (CNIs) have failed to improve long-term renal allograft survival. Their association with cardiovascular morbidity in addition to their suboptimal inhibition of a chronic alloimmune response has shifted investigative efforts toward CNI-free regimens. Sotrastaurin, a small molecule targeting protein kinase C isoforms, failed to provide adequate immunosuppression, whereas the Janus kinase 3 inhibitor tofacitinib's success in the treatment of rheumatoid arthritis led to biopharma's abandonment of it as a transplant agent. Like tofacitinib, tocilizumab, a biologic targeting the IL-6 pathway, has been approved for use in rheumatoid arthritis and interest in transplantation has been confined to several investigator-initiated trials. Belatacept, a second-generation...



Viral Origin, Clinical Course, and Renal Outcomes in Patients With BK Virus Infection After Living-Donor Renal Transplantation

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: Pretransplant urinary BKV shedding of donor and recipient is a risk for posttransplant infection. Donor-derived BKV transmission is an important mode of infection. BKV subtype IV may be one of the viral determinants. Early BKV positivity of urine and blood indicates later BKV nephropathy. Decreased renal function may favor BKV infection. (Source: Transplantation)



Risk Factors for BK Polyoma Virus Treatment and Association of Treatment With Kidney Transplant Failure: Insights From a Paired Kidney Analysis

Tue, 22 Mar 2016 16:43:21 +0100

Conclusions: This analysis of kidneys from the same donor in which only 1 transplant was treated for BKPyV identifies specific risk factors (age (Source: Transplantation)



Cytomegalovirus Infection in Pediatric Renal Transplantation and the Impact of Chemoprophylaxis With (Val-)Ganciclovir

Tue, 22 Mar 2016 16:43:21 +0100

Conclusion: Antiviral chemoprophylaxis with VGCV or GCV in recipients with a high or moderate CMV risk is associated with a better preservation of transplant function. Hence, the prevention of CMV replication in this patient population has the potential to improve transplant outcome. (Source: Transplantation)

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