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MedWorm: Laser Surgery



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Laser Surgery



Last Build Date: Mon, 28 Mar 2016 07:07:15 +0100

 



Plantar Hyperhidrosis

Fri, 25 Mar 2016 23:00:00 +0100

This article discusses a range of treatment options including topical aluminum chloride, iontophoresis, injectable botulinum toxin A, glycopyrrolate, oxybutynin, laser, and endoscopic lumbar sympathectomy. Lifestyle changes regarding hygiene, shoe gear, insoles, and socks are also discussed. (Source: Clinics in Podiatric Medicine and Surgery)

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Ozone Gas Bath Combined with Endovenous Laser Therapy for Lower Limb Venous Ulcers: A Randomized Clinical Trial.

Fri, 25 Mar 2016 20:12:02 +0100

CONCLUSIONS: Ozone gas bath combined with EVLT showed improved efficacy for the treatment of lower limb venous ulcers and lower recurrence ratio comparison with EVLT alone. This procedure is a safe and technically feasible. PMID: 27010682 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)



Procedures of cervical conization: a national survey among Italian colposcopy units.

Fri, 25 Mar 2016 05:38:02 +0100

CONCLUSIONS: The administrative regimen in which conizations are performed is an expression of behaviors of different health authorities and hospitals in relation to the costs that this procedure entails. PMID: 27008241 [PubMed - in process] (Source: Minerva Ginecologica)



Safety and usefulness of flexible hand-held laser fibers in microsurgical removal of acoustic neuromas (vestibular schwannomas)

Thu, 24 Mar 2016 23:00:00 +0100

The treatment of acoustic neuromas (AN) or, more anatomically correct, vestibular schwannomas, has gradually changed during time, from life-saving measures to preservation of function and quality of life. In particular, further developments in the last decades have shown that the retrosigmoid approach is a safe and efficacious method for surgery on AN of all sizes: intracanalicular without or with extrameatal extension, without and with brainstem contact and compression [1,2]. Preservation of hearing and facial nerve functions are now primary goals in microsurgical treatment of these tumors, especially in patients with AN having maximum diameter inferior to 2cm [3,4]. (Source: Clinical Neurology and Neurosurgery)



Latex Carrier for Improving Protoporphyrin IX for Photodynamic Therapy

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Photodiagnosis and Photodynamic Therapy)



Management of a vesicovaginal fistula using holmium laser ablation

Wed, 23 Mar 2016 23:00:00 +0100

Conclusion Holmium laser ablation combined with partial vaginal excision may be considered as a management option for a small VVF. (Source: International Urogynecology Journal)

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Molecular Analysis of Apoptosis Pathway after Photodynamic Therapy in Breast Cancer: animal Model study

Wed, 23 Mar 2016 23:00:00 +0100

(Source: Photodiagnosis and Photodynamic Therapy)



Histoanatomical characteristics to increase the success in transoral surgery for hypopharyngeal cancer

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionA precise understanding of the histoanatomical characteristics of the hypopharynx increases the success of TLM, decreases complication rates, and improves laryngeal preservation. Level of EvidenceN/A. Laryngoscope, 2016 (Source: The Laryngoscope)



Selective laser trabeculoplasty in treating post-trabeculectomy advanced primary open-angle glaucoma.

Wed, 23 Mar 2016 14:45:02 +0100

In conclusion, this study demonstrated that SLT could reduce the IOP in post-trabeculectomy patients with POAG, and reduce the daytime IOP fluctuations. PMID: 26998042 [PubMed - as supplied by publisher] (Source: Experimental and Therapeutic Medicine)



Fetal Intra-Peritoneal Transfusion for the Management of Very Early Spontaneous Twin Anemia-Polycythemia Sequence in an Obese Patient With a Whole Anterior Placenta.

Wed, 23 Mar 2016 12:46:02 +0100

We report here a case of TAPS diagnosed at 17 weeks' gestation in an obese patient (BMI 42) with a whole anterior placenta. The only possible treatment at this stage of pregnancy was intra-uterine transfusion (IUT), which was repeated weekly until photocoagulation of placental anastomoses was feasible. Fetoscopic laser surgery is the only curative treatment, but is challenging in TAPS because of the absence of polyhydramnios and the presence of minuscule anastomoses. An anterior placenta and high BMI can make the procedure even more challenging. This case report demonstrates that very early and rapidly progressing TAPS with technically complicated conditions (elevated BMI and anterior placenta) can be successfully managed with IUT until laser procedure is achievable. PMID: 26996223 [P...



Outcomes of radiofrequency ablation (RFA) and CO2 laser for early glottic cancer

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion Both RFA and CO2 laser are safe and effective for the treatment of early glottic cancer. RFA has the advantage of quick voice recovery, low mucosa injury and short operation time, which is worthy for wide clinical application. (Source: American Journal of Otolaryngology)

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The effect of repeat 360-degree selective laser trabeculoplasty on intraocular pressure control in open-angle glaucoma.

Tue, 22 Mar 2016 06:13:02 +0100

CONCLUSION: In a cohort of patients who underwent 360-degree SLT 4 years previously, a second SLT resulted in IOP lowering similar to the first treatment with a possibly more sustained response. PMID: 26995075 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)



Ultra-mini-percutaneous nephrolithotomy: A minimally-invasive option for percutaneous stone removal

Mon, 21 Mar 2016 23:00:00 +0100

Conclusion: This study shows UMP to be an effective and safe procedure for managing stones up to 20 mm. This procedure offers an attractive alternative to shock wave lithotripsy and retrograde intrarenal surgery for managing small stones. (Source: Indian Journal of Urology)



Corneal-Wavefront guided transepithelial photorefractive keratectomy after corneal collagen cross linking in keratoconus

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions Corneal-Wavefront guided transepithelial PRK ablation profiles after conventional CXL yields to good visual, optical, and refractive results. These treatments are safe and efficacious for the correction of refracto-therapeutic problems in keratoconic patients. (Source: Journal of Optometry)



Risk factors for KPC-producing Klebsiella pneumoniae: Watch out for surgery.

Mon, 21 Mar 2016 23:00:00 +0100

This study describes the molecular characteristics and risk factors associated with carbapenem-resistant K. pneumoniae strains. Risk factors associated with KPC-producing K. pneumoniae strains were investigated in this case-control study from May 2011 to May 2013. Bacterial identification was performed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS). Antimicrobial susceptibility was determined by broth microdilution. Carbapenemase production was assessed by both modified Hodge test (MHT) and ertapenem hydrolysis using MALDI-TOF MS. The presence of β-lactamase-encoding genes was evaluated by PCR and DNA sequencing. Alterations in genes encoding K. pneumoniae outer membrane proteins were analysed by PCR and DNA sequencing as well as SDS-PAGE. G...



Comparing the Curative Effects between Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification Surgery: A Meta-Analysis

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions Compared to CPS, FLACS is a safer and more effective method for reducing endothelial cell loss and postoperative central corneal thickening as well as achieving better and faster visual rehabilitation and refractive outcomes. However, there is no difference in final CDVA and surgically induced astigmatism between the two groups. (Source: PLoS One)

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The efficacy and safety of cold‐induced lipolysis in the treatment of pseudogynecomastia

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionCold‐induced lipolysis is a safe, effective therapeutic option in the treatment of pseudogynecomastia. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)



Comparison of performances of femtosecond laser and microkeratome for thin‐flap laser in situ keratomileusis

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsBoth methods of thin‐flap created LASIK were effective, safe, predicable, and stable. FS group had significant improvements in efficacy and safety, confirmed by the efficacy and safety indices, compared to MK group. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)



Comparison of caries diagnostic modalities: A clinical study in 40 subjects

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionThese findings support the usefulness of LF for primary caries detection, and the clinical utility of OCT for early caries detection and monitoring under dental resin restorations and sealants. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)



Hypertrichotic Becker's nevi treated with combination 1,550 nm non‐ablative fractional photothermolysis and laser hair removal

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionThis report demonstrates the utility and safety of combination non‐ablative fractional resurfacing and laser hair removal for the treatment of hypertrichotic Becker's nevi, and monotherapy non‐ablative fractional photothermolysis for atrichotic Becker's nevi. Further comparative studies are necessary to determine optimal laser parameters, treatment schedules, and response duration. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)



Does surgical sympathectomy improve clinical outcomes in patients with refractory angina pectoris?

Mon, 21 Mar 2016 00:00:00 +0100

A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was: In patients with angina pectoris refractory to medical therapy, does surgical sympathectomy improve clinical outcomes? A total of 528 papers were identified using the search protocol described, of which 6 represented the best evidence to answer the clinical question. There were 5 case series and 1 prospective cohort study. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. All 5 of the case series demonstrated an improvement in symptoms, exercise tolerance or quality of life in patients undergoing surgical sympathectomy. An early case series investigating an open approa...



Current practice in Latin America of flexible ureterorenoscopy with laser for treating kidney stones

Sun, 20 Mar 2016 23:00:00 +0100

Conclusions Most participating urologists consider flexible ureterorenoscopy as the first-choice treatment for stones <2cm; a small percentage of these urologists perform >100 ureterorenoscopies per year. More than half of the urologists routinely used fluoroscopy and ureteral access sheath; the most common method for determining the stone-free state is plain abdominal radiography. (Source: Actas Urologicas Espanolas)



Evaluation of temperature change during antimicrobial photodynamic therapy with two different photosensitizers in dental caries

Sun, 20 Mar 2016 23:00:00 +0100

(Source: Photodiagnosis and Photodynamic Therapy)

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Prostate tissue retrieval after holmium laser enucleation of the prostate; assessment of non-morcellation approaches

Sat, 19 Mar 2016 00:00:00 +0100

Conclusion In the absence or malfunction of a tissue morcellator, or whenever concomitant pathology indicates laparotomy, non-morcellation tissue retrieval approaches are feasible options for endourologists practicing transurethral enucleation of prostate adenoma. These approaches are valid alternatives retaining most of the advantages of the transurethral prostate enucleation procedure. (Source: Arab Journal of Urology)



Accuracy of the Barrett True-K formula for intraocular lens power prediction after laser in situ keratomileusis or photorefractive keratectomy for myopia

Sat, 19 Mar 2016 00:00:00 +0100

To compare the accuracy of the Barrett True-K formula with other methods available on the American Society of Cataract and Refractive Surgery (ASCRS) post-refractive surgery intraocular lens (IOL) power calculator for the prediction of IOL power after previous myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). (Source: Journal of Cataract and Refractive Surgery)



Pars plana vitrectomy with juxtapapillary laser photocoagulation versus vitrectomy without juxtapapillary laser photocoagulation for the treatment of optic disc pit maculopathy: the results of the KKESH International Collaborative Retina Study Group

Fri, 18 Mar 2016 00:00:00 +0100

Conclusions PPV with JLP for optic disc pit maculopathy had similar functional and anatomic outcomes compared with vitrectomy without JLP. (Source: British Journal of Ophthalmology)



Anterior chamber interleukin 1{beta}, interleukin 6 and prostaglandin E2 in patients undergoing femtosecond laser-assisted cataract surgery

Fri, 18 Mar 2016 00:00:00 +0100

Conclusions Inflammatory cytokines IL-1β, IL-6 and PGE2 significantly increased after femtosecond laser-assisted cataract surgery, which maybe the cause of intraoperative miosis seen in these patients. (Source: British Journal of Ophthalmology)



The effect of He-Ne and Ga-Al-As lasers on the healing of oral mucosa in diabetic mice

Fri, 18 Mar 2016 00:00:00 +0100

This study aims to determine the effect of LLLT (He-Ne and Ga-Al-As laser) on the process of wound healing in the hard palate among diabetic and non-diabetic mice. 90 adult male mice were divided into six groups. Type 1 Diabetes Mellitus was induced in three groups by means of injection of STZ. Of these, one group was irradiated with He-Ne laser (DH group), one with Ga-Al-As laser (DG group) and one did not undergo any LLLT (DC group). The remaining groups were non-diabetic which were allotted to laser therapy with He-Ne laser (NH group) or with Ga-Al-As laser (NG group) or no LLLT (NC group). Five animals from each group were killed on the third, seventh, and 14days after surgery, and biopsies were made for histological analysis. On the 3rd and 7th day after the surgery, the number of pol...

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Generalized Arterial Calcification in a Recipient Twin: Discordant Fetal Hemodynamics Result in Differing Phenotypes in Monozygotic Twins with an ABCC6 Mutation

Wed, 16 Mar 2016 13:07:07 +0100

We report the case of a TTTS recipient with moderate cardiomyopathy at diagnosis who developed progressive calcification of the pulmonary arteries and aorta after successful in utero laser therapy. Postnatally, both twins were diagnosed with a heterozygous ABCC6 gene mutation associated with GACI. The recipient had progressive supravalvular pulmonary and aortic stenosis, was treated with bisphosphonate therapy, and successfully underwent cardiac surgery at 4 months of age. The donor twin with the same mutation remained phenotypically normal at 15 months of age. This case illustrates monozygotic fetuses with discordant in utero hemodynamics, with subsequent development of phenotypic differences. TTTS recipients with arterial calcifications should undergo genetic testing for GACI.Fetal Diagn...



SPY technology as an adjunctive measure for lower extremity perfusion

Wed, 16 Mar 2016 00:00:00 +0100

Lack of a reliable outcome measure often leads to excessive or insufficient interventions for critical limb ischemia (CLI). SPY technology (Novadaq Technologies Inc, Bonita Springs, Fla), widely adapted by plastic and general surgeons, uses laser-assisted fluorescence angiography (LAFA) to assess tissue perfusion. We sought to determine the role of SPY as an alternative, perhaps more reliable outcome measure for vascular interventions. (Source: Journal of Vascular Surgery)



Effect of Cervical Length Recovery after Laser Surgery for Twin-Twin Transfusion Syndrome

Wed, 16 Mar 2016 00:00:00 +0100

Conclusion Severity of polyhydramnios does not correlate with preoperative cervical length, and variability of the cervix postoperatively does not appear to affect gestational age at delivery.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)



Photodynamic inactivation of Candida albicans biofilm: Influence of the radiant energy and photosensitizer charge

Wed, 16 Mar 2016 00:00:00 +0100

(Source: Photodiagnosis and Photodynamic Therapy)



Varicose veins and their management

Tue, 15 Mar 2016 00:00:00 +0100

This article discusses epidemiology, diagnosis and management of varicose veins, including the latest endovascular and targeted open surgical techniques. (Source: Surgery (Oxford))

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Prospects of singlet oxygen luminescence monitoring: Kinetics at different locations on living mice

Mon, 14 Mar 2016 00:00:00 +0100

Photodynamic Therapy (PDT) is a non-invasive treatment of cancer, skin diseases, age-related macular degeneration and other affections.[1] PDT involves administration of a preferably targeting drug, the photosensitizer (PS) and its activation by light. The light absorption excites the PS to its singlet state. Efficient PS have a high probability of intersystem crossing to a long-lived triplet state. This triplet state of the PS enables an energy transfer to molecular oxygen. The triplet ground state of molecular oxygen is excited to form singlet oxygen (). (Source: Photodiagnosis and Photodynamic Therapy)



Prospects of in vivo singlet oxygen luminescence monitoring: Kinetics at different locations on living mice

Mon, 14 Mar 2016 00:00:00 +0100

Photodynamic Therapy (PDT) is a non-invasive treatment of cancer, skin diseases, age-related macular degeneration and other affections.[1] PDT involves administration of a preferably targeting drug, the photosensitizer (PS) and its activation by light. The light absorption excites the PS to its singlet state. Efficient PS have a high probability of intersystem crossing to a long-lived triplet state. This triplet state of the PS enables an energy transfer to molecular oxygen. The triplet ground state of molecular oxygen is excited to form singlet oxygen (). (Source: Photodiagnosis and Photodynamic Therapy)



Effect of multiple‐sweeping on ablation performance during ex vivo laser nephrectomy

Mon, 14 Mar 2016 00:00:00 +0100

ConclusionA combination of coagulation barriers, spatial distribution of power, and temporal interplay of optical energy could attribute to continuously lessen the amount of the ablated tissue with the multiple sweeps. Optical power modulation with varying fiber conditions (speed and distance) will be examined to optimize surgical parameters and to sustain the equivalent ablation performance of the first sweep with the multiple sweeping for laser nephrectomy. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)



Tricuspid Regurgitation following Lead Extraction: Risk Factors and Clinical Course.

Sun, 13 Mar 2016 03:13:02 +0100

CONCLUSIONS: TR following lead extraction is not uncommon but does not seem to affect survival or outcomes such as need for valve surgery. Its long-term effects remain to be determined. PMID: 26964274 [PubMed - in process] (Source: The Israel Medical Association Journal)



Is low level laser therapy effective in management of pain and swelling after mandibular third molar surgery

Sat, 12 Mar 2016 00:00:00 +0100

This study was conducted to evaluate the effect of low level laser therapy (LLLT) on reducing pain and swelling following removal of impacted third molars. (Source: Journal of Oral and Maxillofacial Surgery)



The use of laser in hysteroscopic surgery.

Fri, 11 Mar 2016 18:18:06 +0100

Authors: Nappi L, Sorrentino F, Angioni S, Pontis A, Greco P Abstract The acronym LASER, is a term constructed from Light Amplification by Stimulated Emission of Radiation. Lasers are commonly described by the emitted wavelength, which determines the colour of the light, as well as the active lasing medium. Currently, over 40 types of lasers have been developed with a wide range of both industrial and medical uses. Moreover, advances made by gynaecologists in the field of operative hysteroscopy have developed a very great interest in the use of surgical lasers. Improvements in optics, light sources, hysteroscopes, and lasers have led several gynecologists to begin investigating the use of lasers for intrauterine surgical procedures. This review focuses on the physics, tissue intera...



Supraglottoplasty as treatment of exercise induced laryngeal obstruction (EILO)

Fri, 11 Mar 2016 04:34:10 +0100

This study is the second larger-scale study that documents the positive effect of supraglottoplasty as treatment of EILO in terms of reduced respiratory symptoms and decreased laryngeal obstruction assessed by post-operative CLE test. We suggest that surgery is a well-tolerated and effective treatment option for selected EILO patients with moderate to severe supraglottic obstruction during exercise and a high level of physical activity. (Source: European Archives of Oto-Rhino-Laryngology)



Potency of different red light sources in photodynamic induction of cell death in a squamous cell carcinoma cell line

Fri, 11 Mar 2016 00:00:00 +0100

(Source: Photodiagnosis and Photodynamic Therapy)

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Salvage transoral laser microsurgery for recurrent glottic carcinoma after primary laser‐assisted treatment: Analysis of prognostic factors

Fri, 11 Mar 2016 00:00:00 +0100

ConclusionThe age of the patient and the pathological status of surgical margins after salvage TLM could be useful for planning a closer endoscopic/radiological follow‐up in selected patients at high risk of recurrence. Other appropriately designed studies are needed to see if an open surgical approach should be considered for younger patients (<65 years old) with recurrent glottic carcinoma after primary TLM. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Comparative multidimensional assessment of laryngeal function and quality of life after radiotherapy and laser surgery for early glottic cancer

Fri, 11 Mar 2016 00:00:00 +0100

ConclusionThe multidimensional assessment showed that early glottic cancer could be successfully treated by either RT or LS‐Ex with equivalent posttherapeutic laryngeal function and QOL. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Five years of treatment for retinopathy of prematurity in Sweden: results from SWEDROP, a national quality register.

Fri, 11 Mar 2016 00:00:00 +0100

CONCLUSIONS: The present study reveals similar incidences of ROP and frequencies of treatment during the 5-year study period. Many surgeons were involved in treatment of a rather limited number of infants. The results call for national discussions on organisation of ROP treatment. PMID: 26969711 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)



Role of VEGF Inhibition in the Treatment of Retinopathy of Prematurity.

Thu, 10 Mar 2016 16:28:01 +0100

Authors: Eldweik L, Mantagos IS Abstract Retinopathy of prematurity (ROP) is a potentially blinding disease characterized by retinal neovascularization, which eventually can lead to tractional retinal detachment. Improvements have been made regarding the management of retinopathy of prematurity (ROP) since it was described in the Cryotherapy for Retinopathy of Prematurity study. A more appropriate time for therapeutic intervention was defined by the Early Treatment for Retinopathy of Prematurity (ETROP) trial. Advances in screening strategies with the use of digital imaging systems are now available. All of this and the use of laser photocoagulation and vitreoretinal surgery have contributed to significant increases in favorable outcomes and decreases in child blindness secondary t...



The Role of the Immune System in Glaucoma: Bridging the Divide Between Immune Mechanisms in Experimental Glaucoma and the Human Disease.

Thu, 10 Mar 2016 16:28:01 +0100

This article explores the current understanding of immune reactions in glaucoma, which could lead to a new paradigm of treatment for human disease. PMID: 26959140 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)

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Stem cells used to repair children's eyes after cataracts

Thu, 10 Mar 2016 12:00:00 +0100

ConclusionThis is an exciting study, which shows that a new technique may be a much better alternative for treating babies born with congenital cataracts. It also suggests new ways for scientists to look at tissue regeneration from stem cells in the future.We now need to see the study repeated on a larger scale, to see if the initial results can be replicated. Only 12 children were treated with the new technique in this study, which is a very small set of results to rely on. We also need to see long-term follow up on these children, to find out how long the regenerated lenses continue to be free from cataracts. The suggestion that this treatment may also be suitable for adults should be treated with caution. As the researchers say, age-related cataracts are different from congenital catara...



Effect of low-level laser therapy on tooth sensitivity induced by in-office bleaching

Thu, 10 Mar 2016 00:00:00 +0100

This study aimed to investigate the effect of low-level laser therapy (LLLT) on tooth sensitivity induced by in-office bleaching. Sixty-six patients enrolled in this randomized clinical trial. Following the in-office procedure with 40 % hydrogen peroxide, the participants were randomly divided into three groups. The patients in group 1 received irradiation from a low-level red laser (LLRL; 660 nm, 200 mW, 15 s, 12 J/cm2), whereas participants in group 2 were subjected to a low-level infrared laser (LLIL; 810 nm) under similar conditions as in group 1. In group 3 (placebo), the laser treatment was the same as that in groups 1 and 2, but without energy output. The degree of tooth sensitivity was recorded at 1, 24, and 48 h after bleaching using a visual analog scale (VAS). The change ...



The impact of Er:YAG laser enamel conditioning on the microleakage of a new hydrophilic sealant—UltraSeal XT® hydro™

Thu, 10 Mar 2016 00:00:00 +0100

Abstract UltraSeal XT® hydro™ is a new hydrophilic, light-cured, methacrylate-based pit and fissure sealant which has been developed by Ultradent Products, USA. The sealant is highly filled with a 53 wt.% mixture of inorganic particles which confer both thixotropy and radiopacity. The principal purpose of this study was to investigate the microleakage of UltraSeal XT® hydro™ as a function of different enamel etching techniques. The occlusal surfaces of sound, extracted human molars were either acid etched, Er:YAG laser irradiated or successively laser irradiated and acid etched. UltraSeal XT® hydro™ was applied to each group of teeth (n = 10) which were subjected to a thermocycling process consisting of 2500 cycles between 5 and 50 °C with a dwell time of 30 s. M...



Evaluation of the effects of pulsed wave LLLT on tibial diaphysis in two rat models of experimental osteoporosis, as examined by stereological and real-time PCR gene expression analyses

Thu, 10 Mar 2016 00:00:00 +0100

This study intended to evaluate the impacts of PW LLLT on the cortical bone of osteoporotic rats’ tibias in two experimental models, ovariectomized and dexamethasone-treated. We divided the rats into four ovariectomized induced OP (OVX-d) and four dexamethasone-treated (glucocorticoid-induced OP, GIOP) groups. A healthy (H) group of rats was considered for baseline evaluations. At 14 weeks following ovariectomy, we subdivided the OVX-d rats into the following groups: (i) control which had OP, (ii) OVX-d rats treated with alendronate (1 mg/kg), (iii) OVX-d rats treated with LLLT, and (iv) OVX-d rats treated with alendronate and PW LLLT. The remaining rats received dexamethasone over a 5-week period and were also subdivided into four groups: (i) control rats treated with intramuscular (i...



The dark art of light measurement: accurate radiometry for low-level light therapy

Thu, 10 Mar 2016 00:00:00 +0100

Abstract Lasers and light-emitting diodes are used for a range of biomedical applications with many studies reporting their beneficial effects. However, three main concerns exist regarding much of the low-level light therapy (LLLT) or photobiomodulation literature; (1) incomplete, inaccurate and unverified irradiation parameters, (2) miscalculation of ‘dose,’ and (3) the misuse of appropriate light property terminology. The aim of this systematic review was to assess where, and to what extent, these inadequacies exist and to provide an overview of ‘best practice’ in light measurement methods and importance of correct light measurement. A review of recent relevant literature was performed in PubMed using the terms LLLT and photobiomodulation (March 2014–March 2015) to inv...

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Surgical Management of a Case of a 360-Degree Giant Retinal Break

Wed, 09 Mar 2016 20:19:19 +0100

Conclusions: The chandelier-assisted bimanual technique is an effective method for dealing with adherent posterior hyaloid and epiretinal membranes in a detached retina, particularly in cases of complex open-funnel retinal detachment. Proper shaving of the anterior leaflet and refreshing the edges of the retinal break helps decrease postoperative PVR formation. Direct PFC-silicone oil exchange in giant retinal breaks helps minimize the risk of retinal slippage occurrence.Ophthalmologica (Source: Ophthalmologica)



The treatment of problematic hemangiomas in children with propranolol and 940nm diode laser

Wed, 09 Mar 2016 00:00:00 +0100

Hemangiomas are common skin lesion, affecting 10–12% of children (Source: Journal of Pediatric Surgery)



Abdominal Subcutaneous Mass After Laser-Assisted Lipolysis and Immediate Multiple Treatments with a Dual-Wavelength Laser, Vacuum and Massage Device

Wed, 09 Mar 2016 00:00:00 +0100

Body contouring by means of minimally invasive procedures is a growing trend. Current approaches to body contouring often involve a combination of surgical techniques (eg, laser-assisted liposuction) and a series of noninvasive device-based treatments aimed at accelerating recovery and improving aesthetic outcomes. In this case study, we describe a 38-year-old woman who presented with an abdominal-wall mass that resembled a tumor when assessed with magnetic resonance imaging. Twenty-six months before presenting to our office, the patient had undergone laser lipolysis and a series of treatments with a device that delivered dual-wavelength laser energy and vacuum-assisted massage. To address the patient's concerns, we removed the mass and performed abdominal dermolipectomy. No postoperative ...






Monitoring of Partial and Full Venous Outflow Obstruction in a Porcine Flap Model using Laser Speckle Contrast Imaging

Wed, 09 Mar 2016 00:00:00 +0100

In this study, we evaluated laser speckle contrast imaging and laser Doppler flowmetry to assess their possibilities to detect partial and full venous outflow obstruction, as well as full arterial occlusion, in a porcine flap model. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

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Levonorgestrel-releasing intrauterine system placement for severe uterine cervical stenosis after conization: two case reports

Wed, 09 Mar 2016 00:00:00 +0100

Conclusions To the best of our knowledge, this is the first report to confirm the usefulness and easy applicability of the levonorgestrel-releasing intrauterine system for uterine cervical stenosis. Although we had success with the method, this study of two patients is preliminary. Further study with larger numbers of patients is necessary to confirm the usefulness of our technique. (Source: Journal of Medical Case Reports)



Descemet Membrane Detachment in Femtosecond Laser-Assisted Cataract Surgery

Tue, 08 Mar 2016 07:21:26 +0100

Conclusions: DMD can occur after femtosecond laser-assisted cataract surgery, although it is a rare complication as it is in traditional phacoemulsification. The surgeon must be prepared to recognize it, manage it intraoperatively, and treat it postoperatively to reduce the risk of permanent damage to the eye. (Source: Cornea)



Electrical Stimulation of the Trigeminal Ganglion and Intrathecal Drug Delivery Systems for the Management of Corneal Neuropathic Pain

Tue, 08 Mar 2016 07:21:26 +0100

Conclusions: Electrical stimulation of the trigeminal ganglion and a high cervical intrathecal pain pump can be used in the management of corneal neuropathic pain unresponsive to ocular and systemic approaches. (Source: Cornea)



Errors in Treatment of Lower-order Aberrations and Induction of Higher-order Aberrations in Laser Refractive Surgery

Sat, 05 Mar 2016 05:19:20 +0100

No abstract available (Source: International Ophthalmology Clinics)



Postoperative Pain After Laser Refractive Surgery

Sat, 05 Mar 2016 05:19:20 +0100

No abstract available (Source: International Ophthalmology Clinics)

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Deep sclerectomy in primary open-angle glaucoma and exfoliative glaucoma.

Sat, 05 Mar 2016 00:00:00 +0100

CONCLUSIONS: The IOP 1 week postoperatively seems to be a prominent indicator of surgical success. Deep sclerectomy is effective in reducing IOP in POAG and EXG subgroups, with reoperations more common in EXG eyes. PMID: 26951530 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)



What Exactly Does Laser Surgery Mean?

Fri, 04 Mar 2016 00:00:00 +0100

(Source: About.com Ovarian Cancer)



Adult tonsillectomy: postoperative pain depends on indications

Fri, 04 Mar 2016 00:00:00 +0100

Conclusion Patients with recurrent tonsillitis qualified for tonsillectomy reported lower pain intensity than those without recurrent tonsillitis and the pain scores were unrelated to nerve fibers density. (Source: Brazilian Journal of Otorhinolaryngology)



Does anemia–polycythemia complicating twin–twin transfusion syndrome affect outcome after fetoscopic laser surgery?

Fri, 04 Mar 2016 00:00:00 +0100

ConclusionCases of TTTS with anemia–polycythemia were more likely to be found in parous and older women and were characterized by fewer vascular anastomoses. TTTS with anemia–polycythemia was not associated with worse perinatal outcome after laser therapy. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd. (Source: Ultrasound in Obstetrics and Gynecology)



Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities

Fri, 04 Mar 2016 00:00:00 +0100

ConclusionsThe hypothesis that PIRL results in minimal scar formation with improved cosmetic outcomes was positively verified. In particular the resection of skin tumors or pathological scars, such as hypertrophic scars or keloids, are promising future fields of PIRL application. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)

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Long‐term outcome following thulium vaporesection of the prostate

Fri, 04 Mar 2016 00:00:00 +0100

ConclusionsThuVaRP is both an effective and safe treatment procedure for symptomatic BPO (with a low occurrence of complications). Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)



Diode Laser for Laryngeal Surgery: a Systematic Review

Fri, 04 Mar 2016 00:00:00 +0100

Conclusion: The literature lacks studies on the ideal parameters of the diode laser in laryngeal surgery. The available data indicate that diode laser is a useful tool that should be considered in laryngeal surgeries. Thus, large, well-designed studies correlated with diode compared with other lasers are needed to better estimate its effects.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)



Treatment of Kidney Stone in a Kidney-Transplanted Patient with Mini-Percutaneous Laser Lithotripsy: A Case Report

Thu, 03 Mar 2016 20:35:40 +0100

We report a case of a kidney-transplanted patient with urolithiasis treated with mini-percutaneous laser lithotripsy. The patient presented with renal dysfunction and graft hydronephrosis. Diagnostic procedures revealed ureterolithiasis as a cause of obstruction, and percutaneous nephrostomy was inserted as a temporary solution. Before surgery, the stone migrated to the renal pelvis. Mini-percutaneous laser lithotripsy was successfully performed, and during surgery, all stone fragments were removed. Six months after successful treatment, the patient has good functioning and stone-free graft.Case Rep Nephrol Dial 2016;6:26-31 (Source: Case Reports in Nephrology and Dialysis)

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The combination of phacoemulsification surgery and intravitreal triamcinolone injection in patients with cataract and diabetic macular edema

Thu, 03 Mar 2016 00:00:00 +0100

Conclusions PHACO surgery combined with IVTA injection improves BCVA and provides a decrease in CMT in diabetic patients with CSME. Additional macular grid laser photocoagulation after surgery helps to preserve this improvement in BCVA and decrease in CMT. (Source: Saudi Journal of Ophthalmology)



Pancreatic manifestations in von Hippel–Lindau disease: A case report

Thu, 03 Mar 2016 00:00:00 +0100

Conclusion The management of VHL disease-associated benign pancreatic cystic lesions involves interval monitoring with cross-sectional imaging for malignant changes/development. (Source: International Journal of Surgery Case Reports)



Safety of a picosecond laser with diffractive lens array (DLA) in the treatment of Fitzpatrick skin types IV to VI: A retrospective review

Thu, 03 Mar 2016 00:00:00 +0100

Laser therapy in patients with skin of color is associated with an increased rate of complications. The 755-nm picosecond laser with the diffractive lens array (DLA) has been used for the treatment of scars, striae, and rejuvenation. By delivering high energy to focused areas, the DLA minimizes complications. (Source: Journal of the American Academy of Dermatology)



Glaucoma Patient Treatment Preferences

Thu, 03 Mar 2016 00:00:00 +0100

Intraocular pressure, the only modifiable risk factor for glaucoma, is traditionally lowered with topical medication, laser or invasive surgery.1,2 More recently, there has been increased interest in alternative methods for lowering intraocular pressure through the use of minimally invasive extraocular drug delivery implants, such as punctual plugs, as well as more invasive surgical implants or intraocular injectable medication depots. The main goal of these alternative methods of drug delivery is to supplant the need for daily topical medication instillation that is associated with side effects and poor adherence. (Source: Ophthalmology)



Medical Complications of Tattoos: A Comprehensive Review

Thu, 03 Mar 2016 00:00:00 +0100

Abstract Tattoos are defined as the introduction of exogenous pigments into the dermis in order to produce a permanent design. This process may occur unintentional or may be deliberately administered for cosmetic or medical reasons. Tattoos have been around for over 5000 years and over time have evolved to represent a common cosmetic practice worldwide. Currently, adverse reactions are relatively rare and generally unpredictable and predominantly include immune-mediated reactions and skin infections. Along with better healthcare standards and more stringent public health mandates such as the provision of disposable needles, major infectious complications related to hepatitis and human retroviral infections have decreased significantly. When they do occur, skin infections are most...

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Retina Implant drums up $28m

Wed, 02 Mar 2016 16:07:57 +0100

Retina Implant said this week that it raised $28.2 million (€26 million) in private equity funding for its Alpha IMS device, which is designed to treat blind patients with retinitis pigmentosa. The round including contributions from new and existing backers, the Reutlingen, Germany-based company said. The proceeds are earmarked for new clinical centers and winning reimbursement in more markets for the Alpha IMS subretinal microchip. “This re-investment is incredibly important to us as it solidifies our investors’ belief in our vision. This continued commitment will allow us to make great leaps forward to help bring this technology to the people that need it most,” CEO Walter Wrobel said in prepared remarks. “We are simultaneously building out the arsenal of s...



Cerebral blood flow reactivity in patients undergoing selective amygdalohippocampectomy for epilepsy of mesial temporal origin. A prospective randomized comparison of the trans-Sylvian and the transcortical approach.

Wed, 02 Mar 2016 14:06:02 +0100

DISCUSSION: Our findings provide the first invasively measured evidence that patients with mesial temporal lobe epilepsy have preserved cerebral blood flow responses to alterations in CO2. In addition, local cortical SO2 was higher in the TS group than in the TC group after selAH. This may be a sign of reactive cortical vessel dilation after proximal vessel manipulation associated with the TS approach. In contrast, the lower values of SO2 after the TC approach indicate tissue ischaemia surrounding the surgical corridor surrounding the corticotomy. PMID: 26923574 [PubMed - as supplied by publisher] (Source: Neurological Research)



Unilateral Acute Angle-Closure Glaucoma After Lumbar Spine Surgery: A Case Report and Systematic Review of the Literature

Tue, 01 Mar 2016 06:00:00 +0100

Conclusion. Although it is not practical to screen all patients through ophthalmologic referral, there may be a role for targeted preoperative screening of patients with risk factors for AACG. Level of Evidence: 5 (Source: Spine)



Endoscopic Cycloplasty (ECPL) and Lens Extraction in the Treatment of Severe Plateau Iris Syndrome

Tue, 01 Mar 2016 06:00:00 +0100

Purpose: To describe the anatomic and clinical results of the treatment of severe plateau iris syndrome with lens extraction and endoscopic cycloplasty (ECPL). A secondary aim was to describe 4 novel ultrasound biomicroscopy (UBM) measurements for plateau iris syndrome. Design: Prospective case series with UBM evaluation. Methods: Included were 12 eyes of 6 patients with plateau iris refractory to laser iridotomy and iridoplasty, miotic and other glaucoma medical treatment, with appositional angle closure in at least 3 quadrants. Treatment consisted of lens extraction and ECPL, an endoscopic diode laser treatment of the ciliary processes in the superior, nasal, and inferior quadrants. UBM measurements were taken in all quadrants before and after surgery. The untreated temporal quadrants ...



The Bilateral Dufourmentel Flap for Repair of Nasal Dorsum Defects After Mohs Micrographic Surgery

Tue, 01 Mar 2016 06:00:00 +0100

CONCLUSION: The birhombic flap is a reproducible, one-stage flap for small to large defects of the nasal dorsum that consistently produces topographic restoration with minimal risk of aesthetic or functional complication. The use of 2 opposing flaps redistributes the secondary defect, thus minimizing the potential for lower nasal distortion when closing the flaps' donor sites. (Source: Dermatologic Surgery)

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Who are the Pioneers? A Critical Analysis of Innovation and Expertise in Cutaneous Noninvasive and Minimally Invasive Cosmetic and Surgical Procedures

Tue, 01 Mar 2016 06:00:00 +0100

CONCLUSION: Dermatology was identified as the leading specialty for the majority of noninvasive and minimally invasive cosmetic procedures. Other specialties have also contributed important literature to this area. (Source: Dermatologic Surgery)



Nonablative Fractional Laser Resurfacing for Acne Scarring in Patients With Fitzpatrick Skin Phototypes IV-VI

Tue, 01 Mar 2016 06:00:00 +0100

CONCLUSION: The nonablative 1550-nm fractional laser is safe and efficacious in treating acne scaring in Fitzpatrick skin types IV to VI. Self-limited postinflammatory hyperpigmentation was a common occurrence, especially with higher treatment densities. (Source: Dermatologic Surgery)



A Comparative Split-Face Study Using Different Mild Purpuric and Subpurpuric Fluence Level of 595-nm Pulsed-Dye Laser for Treatment of Moderate to Severe Acne Vulgaris

Tue, 01 Mar 2016 06:00:00 +0100

CONCLUSION: This study demonstrates that PDL is effective in reducing acne lesions using purpuric and subpurpuric fluences. However, there was no statistically significant difference in acne lesion count between the higher and lower fluences. (Source: Dermatologic Surgery)



Surgical Treatment of Chronic Hidradenitis Suppurativa: CO2 Laser Stripping—Second Intention Technique

Tue, 01 Mar 2016 06:00:00 +0100

No abstract available (Source: Dermatologic Surgery)



Successful Treatment of Argyria Using the Picosecond Alexandrite Laser

Tue, 01 Mar 2016 06:00:00 +0100

No abstract available (Source: Dermatologic Surgery)

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Combined Intralesional Neodymium-Doped Yttrium Aluminium Garnet Laser and Intratumoral Ligation as Curative Treatment for Craniofacial Arteriovenous Malformations

Tue, 01 Mar 2016 06:00:00 +0100

In conclusion, this minimally invasive technique was successful in curing AVM without complication. With more clinical study and development of soft tissue monitoring tools, it is possible that intralesional laser could become the treatment of choice for all cutaneous AVM. (Source: Journal of Craniofacial Surgery)



Improving the accuracy of brain tumor surgery via Raman-based technology.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Hollon T, Lewis S, Freudiger CW, Sunney Xie X, Orringer DA Abstract Despite advances in the surgical management of brain tumors, achieving optimal surgical results and identification of tumor remains a challenge. Raman spectroscopy, a laser-based technique that can be used to nondestructively differentiate molecules based on the inelastic scattering of light, is being applied toward improving the accuracy of brain tumor surgery. Here, the authors systematically review the application of Raman spectroscopy for guidance during brain tumor surgery. Raman spectroscopy can differentiate normal brain from necrotic and vital glioma tissue in human specimens based on chemical differences, and has recently been shown to differentiate tumor-infiltrated tissues from noninfiltrated ti...



Effect of low-level laser therapy on open wound healing

Tue, 01 Mar 2016 00:00:00 +0100

Adjunctive therapies can be used in an attempt to enhance full-thickness wound healing. Low-level laser therapy (LLLT) is a modality utilized to accelerate wound healing based on biomodulation at the cellular level. Any biological effect of this low level of radiation is attributed to direct effect of radiation rather than heating of the tissues and is often termed cold laser. The exact mechanism is unknown, but LLLT may stimulate cellular processes via photon activation of cytochrome oxidase, resulting in energy production in mitochondria, then leading to synthesis of proteins involved in cellular repair, as well as promoting cellular growth, cellular differentiation, and prostaglandin synthesis. (Source: Advances in Small Animal Medicine and Surgery)



Addressing risk factors, screening, and preventative treatment for diabetic retinopathy in developing countries: a review

Tue, 01 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Ophthalmology)



An enlarged intramuscular venous malformation in the femoral region successfully treated with complete resection

Mon, 29 Feb 2016 00:00:00 +0100

CONCLUSION The therapy for venous malformations should be decided based on the degree of disability in daily living, adjacent tissue damage, and cosmetic concerns after appropriate differential diagnostic investigations and biopsy. (Source: International Journal of Surgery Case Reports)

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Fiber type as compared to wavelength may contribute more to improving postoperative recovery following endovenous laser ablation

Mon, 29 Feb 2016 00:00:00 +0100

Conclusions The use of a JT fiber appeared to be more significant in reducing pain and bruising as compared to a longer wavelength. Moreover, the results appeared additive, and the cohort using 1470 nm with a JT fiber produced the best treatment outcomes. Additional study is required to confirm the efficacy and durability of the various iterations evaluated; however, these data should be taken into consideration when undertaking treatment with endovenous laser ablation. (Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders)



Lutetium(III) acetate phthalocyanines for photodynamic therapy applications: Synthesis and photophysicochemical properties

Mon, 29 Feb 2016 00:00:00 +0100

The phthalocyanines (Pcs), discovered by chance in the beginning of XX century, belong to the second generation photosensitizers for photodynamic therapy (PDT) of cancer [1,2]. The structure of Pcs is defined as favorable for molecular design [3,4]. The additions of different functional groups can happen on the peripheral (β) and the non-peripheral (α) positions as well as axially to the coordinated metal ion [5]. The tetra-substituted phthalocyanines are found to be more proper photosensitizers (PS) for PDT than the octa-substituted PS analogues due to the higher dipole moments [4,5]. (Source: Photodiagnosis and Photodynamic Therapy)



Steatocystoma Multiplex: a Review

Sun, 28 Feb 2016 00:00:00 +0100

Publication date: Available online 27 February 2016 Source:Journal of Dermatology & Dermatologic Surgery Author(s): Manahel Mahmood AlSabbagh Steatocystoma multiplex is an uncommon benign disorder typically manifests as multiple asymptomatic intradermal cysts. It can be sporadic, familial or a part of a syndrome. Rare variants can be easily misdiagnosed. Histologically, it appears as an epithelium-lined cystic wall associated with sebaceous lobules. Treatment is needed if symptomatic or for cosmetic issues with best results reported following radiofrequency, laser therapy and minimally invasive procedures. (Source: Journal of Dermatology and Dermatologic Surgery)



Issue Information ‐ Toc

Sun, 28 Feb 2016 00:00:00 +0100

(Source: Lasers in Surgery and Medicine)



Treatment of pigmentary disorders in patients with skin of color with a novel 755 nm picosecond, Q‐switched ruby, and Q‐switched Nd:YAG nanosecond lasers: A retrospective photographic review

Sun, 28 Feb 2016 00:00:00 +0100

ConclusionThe 755 nm alexandrite picosecond, 694 nm ruby, 532 nm, and 1064 nm neodynium:YAG nanosecond lasers appear to be safe and effective modalities for removal of pigmentary disorders in skin of color patients with no long‐term complications if used appropriately. This study demonstrates the potential of the 755 nm alexandrite picosecond laser in further clinical applications beyond tattoo removal. While the Q‐switched lasers were effective, promising results were also observed using an early version of the novel picosecond laser for the removal of pigmentary lesions in SOC patients. As we continue to improve our understanding of the 755 nm picosecond laser, this device may prove to be a safe and effective alternative to the Q‐switched lasers for the treatment of fac...

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News & Announcements

Sun, 28 Feb 2016 00:00:00 +0100

(Source: Lasers in Surgery and Medicine)



Relationships between duplex findings and quality of life in long-term follow-up of patients treated for chronic venous disease.

Sat, 27 Feb 2016 18:53:03 +0100

CONCLUSIONS: Analysis of the available literature confirmed that all four techniques were effective in the abolishment of reflux or obliteration of the GSV. Moreover, well-designed RCTs with large sample size are needed to produce robust long-term data on clinical outcome after treatment of varicose veins and CVI and to better understand the relationships between duplex-derived data and QoL assessments. PMID: 26916775 [PubMed - in process] (Source: Phlebology)



Future opportunities in diabetic retinopathy research

Sat, 27 Feb 2016 02:35:24 +0100

This study summarizes the state of the art in diabetic retinopathy research and provides a perspective on opportunities for future investigations. Recent findings: New insights into the pathophysiology of diabetes and diabetic retinopathy will improve metabolic control. Structure–function analyses are revealing new details of diabetic retinopathy. Intraocular drug therapy provides improved visual outcomes. Together these steps will yield better means to detect and quantify vision loss, and to develop patient-specific treatments to preserve vision for persons with diabetes. Summary: Retinopathy is one of the most successfully treated complications of diabetes and will continue to be an important area of research for patients and their families. (Source: Current Opinion in Endocrinology,...



Arteriovenous malformation of the iris. Two cases.

Thu, 25 Feb 2016 20:23:02 +0100

DISCUSSION: The vascular malformations of the iris may be asymptomatic and go unnoticed or cause recurrent spontaneous hyphemas. Treatment must be individualised and may range from observation to photocoagulation with laser, or even surgery. PMID: 26900041 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)

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Osteonecrosis of the jaw (ONJ): diagnosis and management in 2015

Thu, 25 Feb 2016 19:07:07 +0100

Abstract Osteonecrosis of the jaw (ONJ) has been associated with the use of aminobisphosphonates and denosumab. The vast majority (>90 %) of cases occur in the oncology patient population receiving high doses of intravenous bisphosphonates or subcutaneous denosumab. The incidence of ONJ in the osteoporosis patient population is very low and is estimated at 1–90 per 100,000 patient-years of exposure. In the oncology patient population the incidence appears to be related to dose and duration of exposure, and prevalence has been estimated to be as high as 18.6 %. A number of risk factors in addition to antiresorptive therapy have been identified. These include the presence of periodontal disease, oral surgical procedures with extractions or implants, radiation therapy, chemot...