Last Build Date: Mon, 28 Mar 2016 01:43:44 +0100
Sun, 27 Mar 2016 18:35:02 +0100(MedPage Today) -- Medium-term mortality doubled in smokers with rheumatoid arthritis (Source: MedPage Today Geriatrics)
Sun, 27 Mar 2016 05:28:02 +0100In this study, we found that peritoneal B1a cells underwent proliferation and migrated to the inflamed joint tissue with upregulated RANKL expression during collagen-induced arthritis (CIA) development in mice. Adoptive transfer of B1a cells exacerbated arthritic severity and joint damage while intraperitoneal depletion of B1 cells ameliorated both arthritic symptoms and joint pathology in CIA mice. In culture, RANKL-expressing B1a cells significantly promoted the expansion of osteoclasts derived from bone marrow cells, which were in accord with the in vivo findings of increased osteoclastogenesis in CIA mice transferred with B1a cells. Together, these results have demonstrated a pathogenic role of B1a cells in the development of autoimmune arthritis through RANKL-mediated osteoclastogenes...
Sat, 26 Mar 2016 18:29:01 +0100Regarding Comments by Kaya et al. on "Evaluation of the Choroid, Fovea and Retinal Nerve Fiber Layer in Patients with Rheumatoid Arthritis". Ocul Immunol Inflamm. 2016 Mar 25;:1 Authors: Tetikoglu M, Temizturk F, Sagdik HM, Aktas S, Ozcura F, Ozkan Y, Temizturk S PMID: 27015389 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Sat, 26 Mar 2016 10:49:01 +0100CONCLUSIONS: The results were consistent with the scientific literature in the field. The experience seems to confirm the opportunity of screening programs on arthropathy in cutaneous psoriasis patients. About a quarter of psoriasis patients had relevant arthropathic features, and more than half of these required challenging therapies like biologics. PMID: 27013149 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Sat, 26 Mar 2016 10:22:23 +0100No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Sat, 26 Mar 2016 10:22:23 +0100No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Sat, 26 Mar 2016 10:22:23 +0100No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Fri, 25 Mar 2016 23:00:00 +0100Conclusions Septic arthritis of the sternoclavicular joint is an unusual infection, especially in otherwise healthy adults. Because it is associated with serious complications such as chest wall abscess, prompt diagnosis and appropriate treatment are required. (Source: Journal of Medical Case Reports)
Fri, 25 Mar 2016 23:00:00 +0100Conclusions Return to work is influenced by a combination of patient, clinician and occupational factors. The relationship between each of these needs to be explored in greater depth through further qualitative work to gain a wider understanding of the variables influencing patients’ RTW following hip and knee replacement. (Source: Occupational Medicine)
Fri, 25 Mar 2016 23:00:00 +0100Conclusions Seven compounds, including a new chromanone, were isolated from the antimicrobial dichloromethane extract of the stem bark of E. stricta. Six of the seven compounds showed antibacterial and/or antioxidant activities. These findings provide support for the customary (traditional and contemporary) use of E. stricta bark for the treatment of skin and wound infections. Graphical abstract (Source: Journal of Ethnopharmacology)
Fri, 25 Mar 2016 23:00:00 +0100Conclusions These results suggest that addition of a lateral UKA for arthritis progression following medial UKA is a good option in appropriately selected patients. Level of evidence Observational study without controls, Level IV. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)
Fri, 25 Mar 2016 23:00:00 +0100Publication date: Available online 26 March 2016 Source:Reumatología Clínica (English Edition) Author(s): Fernando Palacios-Cuervo, Andrea Calderón-Rivera, Fátima Espinal-Reyes, Carlos Canelo-Aybar (Source: Reumatologia Clinica)
Fri, 25 Mar 2016 23:00:00 +0100Publication date: Available online 26 March 2016 Source:Reumatología Clínica (English Edition) Author(s): Carolina Diez Morrondo, Lucía Pantoja Zarza, Beatriz San Millán Tejado A high serum level of creatine kinase (CK) is a common reason for referring to medical specialities. Myopathies are one of the causes of elevated levels of CK. McArdle disease is the most common disorder of skeletal muscle carbohydrate metabolism. The cases are presented on 2 patients who were referred to our medical consultation to study the cause of their increased CK levels: a 72-year-old asymptomatic man with high levels of CK detected by chance in a routine analysis, and a 30-year-old woman with very few symptoms, apart from slight muscle pain and tiredness. Electromyography was normal in both patients...
Fri, 25 Mar 2016 17:33:04 +0100Authors: Wen L, Gong P, Liang C, Shou D, Liu B, Chen Y, Bao C, Chen L, Liu X, Liang T, Gong W Abstract Myeloid-derived suppressor cells (MDSCs) and Th17 cells were first discovered in the fields of cancer and autoimmunity, respectively. In recent years, their activities have been explored in other biological and pathological conditions, such as infective diseases and solid organ transplantation. However, the interplay between MDSCs and Th17 cells and the mechanism of their interaction remain obscure. This review summarized and analyzed the relationship between MDSCs and Th17 cells, both of which participate in tumor, autoimmune disease, infection and other conditions. In tumors, the increase in MDSCs at the tumor site is usually accompanied by the accumulation of Th17 cells. Howeve...
Fri, 25 Mar 2016 15:38:08 +0100Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind. Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation. You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic. Research shows that damaged mitochondria can lead to: Schizophrenia and bipolar disorder; Alzheimer’s and Parkinson’s disease; Epilepsy, migraines, and nerve pain; Loss of muscle control and balance; Strokes, heart disease, and coronary artery disease; Chronic fatigue syndrome and fibromyalgia;...
Fri, 25 Mar 2016 15:22:29 +0100(Source: Seminars in Arthritis and Rheumatism)
Fri, 25 Mar 2016 15:22:29 +0100(Source: Seminars in Arthritis and Rheumatism)
Fri, 25 Mar 2016 15:22:12 +0100Conclusion: According with our results in the most conservative scenario about 25% of CHIK cases would develop pCHIK‐CIR (34% if we just consider the most representative studies) and 14% chronic arthritis. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Fri, 25 Mar 2016 15:08:52 +0100Rheumatoid arthritis (RA) is the most common connective tissue disease of autoimmune origin. The disease is characterized by chronic inflammation leading to bone erosions and organ involvement. RA is a progressive disease. It affects the quality of life, leading to disability and death mainly due to premature cardiovascular disease. Early diagnosis and appropriate treatment are essential for prognosis and quality of life improvement. In 2010 the American College of Rheumatology (ACR) and The European League Against Rheumatism (EULAR) established new RA classification criteria. Besides clinical symptoms it includes two immunologic criteria: rheumatoid factor (RF) and anti-citrullinated protein antibodies (anti-CCP antibodies). RF is the first well-known RA immunologic marker. It is observe...
Fri, 25 Mar 2016 14:35:05 +0100(MedPage Today) -- Sifalimumab effective in a phase IIb trial, particularly for skin manifestations (Source: MedPage Today Rheumatology)
Fri, 25 Mar 2016 12:45:07 +0100Only 2.7 percent of U.S. adults hit the four key metrics of living a healthy lifestyle -- abstaining from smoking, eating well, exercising and maintaining a healthy body fat percentage -- according to a disheartening new study. The study's lifestyle benchmarks for health weren't particularly high. Being smoke-free, exercising moderately and eating USDA recommended foods don't seem like particularly difficult marks to hit. So why do so many Americans fall short of living healthy lives? "That is the million dollar question," Ellen Smit, a senior author of the study and an associate professor at the Oregon State University College of Public Health and Human Sciences, told The Huffington Post. "We did not look at why few Americans have healthy lifestyles in this study, but I can spe...
Fri, 25 Mar 2016 12:34:28 +0100Read about 4 patients undergoing bariatric surgery, who subsequently developed systemic autoimmune diseases. Did surgery trigger their diseases? Journal of Clinical Rheumatology (Source: Medscape Today Headlines)
Fri, 25 Mar 2016 12:07:08 +0100Acute rheumatic fever and rheumatic heart disease remain major global health problems. Although strategies for primary and secondary prevention are well established, their worldwide implementation is suboptimum. In patients with advanced valvular heart disease, mechanical approaches (both percutaneous and surgical) are well described and can, for selected patients, greatly improve outcomes; however, access to centres with experienced staff is very restricted in regions that have the highest prevalence of disease. (Source: LANCET)
Fri, 25 Mar 2016 11:40:19 +0100Patients with childhood-onset systemic lupus erythematosus (SLE) who transitioned to adult care without a formal transitioning process had long periods without care despite having moderate disease... (Source: Rheumatology News)
Fri, 25 Mar 2016 11:00:33 +0100by Lisa Fratt An anterior cruciate ligament (ACL) tear can be a devastating sports injury. Every year, 400,000 people, many of them teen and young adult athletes, sustain ACL injuries or tears. Martha Murray, MD, an orthopedic surgeon at Boston Children’s Hospital, worked with a team of colleagues to create a new procedure known as bridge-enhanced ACL repair (BEAR) that encourages natural healing. Watch this animation to see how it works: Why do surgeons need a better way to repair ACL injuries? The current standard of care, surgical ACL reconstruction, is a good solution. But it is linked with a 20 percent risk of re-tearing the ACL, and many young patients face an increased risk of arthritis. Instead of removing the torn ACL and replacing it with a tendon graft, the BEAR technique us...
Fri, 25 Mar 2016 10:27:02 +0100CONCLUSION: After investigators were permitted to modify treatment, etanercept was part of the treatment regimen in 95% of patients. Continuation or addition of etanercept in the 2-year extension resulted in a consistently good risk:benefit profile. TRIAL REGISTRATION: Open-Label Study Comparing Etanercept to Conventional Disease Modifying Antirheumatic Drug (DMARD) Therapy; ClinicalTrials.gov, number NCT00848354; https://clinicaltrials.gov/ct2/show/NCT00848354. PMID: 27006728 [PubMed] (Source: Open Rheumatology Journal)
Fri, 25 Mar 2016 10:27:02 +0100CONCLUSION: Corticosteroid injections have a short efficacy compared to NSAIDs. Prescribing NSAIDs should consider the cons-indications, comorbidities and their deleterious digestive, renal, and cardiovascular effect. PMID: 27006727 [PubMed - as supplied by publisher] (Source: Open Rheumatology Journal)
Fri, 25 Mar 2016 06:34:02 +0100CONCLUSIONS: OHT and SG were common in patients with JIA-associated uveitis. Use of immunosuppressive drugs may decrease the risk of developing OHT. PMID: 27003850 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Fri, 25 Mar 2016 06:34:02 +0100Authors: Kaya A, Sağdiç SK, Topal T PMID: 27002345 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Fri, 25 Mar 2016 06:03:02 +0100Conclusions This prospective observational study provides evidence of the effectiveness of CT-P13 in IBD. PMID: 27002981 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Fri, 25 Mar 2016 00:00:00 +0100Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition with an unclear pathophysiological mechanism affecting different parts of the body. If untreated, the disease can lead to ... (Source: Pediatric Rheumatology)
Fri, 25 Mar 2016 00:00:00 +0100Mevalonate kinase deficiency is a metabolic autoinflammatory syndrome caused by mutations in the MVK gene, mevalonate kinase, the key enzyme in the non-sterol isoprenoid biosynthesis pathway. Two phenotypes of me... (Source: Pediatric Rheumatology)
Thu, 24 Mar 2016 23:00:00 +0100(Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions: Children with active SJIA have profound alterations in expression of microRNAs implicated in monocyte function and polarization. Additionally, one of these, miR‐125a‐5p, is a regulator of immunoregulatory M2b macrophages. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100(Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion. Updated projections suggest arthritis and AAAL will remain large and growing problems for clinical and public health systems, which must plan and create policies and resources to address these future needs. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion We demonstrate an association between the combination of a TNFi with csDMARDs and improved drug retention in axSpA patients, particularly in the subgroup of patients with Infliximab. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion. Effective anti‐inflammatory treatment of axSpA was associated with an increase in fatty lesion scores that was independent of the treatment arm. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion: Among women with RA, initiation of biologic DMARDs was associated with a numerically, but not statistically significant, increase in the risk of high‐grade cervical dysplasia or cervical cancer versus non‐biologics. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion. Secukinumab inhibited radiographic progression in patients with active psoriatic arthritis through 52 weeks of therapy. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100(Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions: Anti‐TNFα are highly effective in refractory inflammatory uveitis. Behçet's disease is associated with increase odds of response. IFX and ADA seem equivalent in terms of efficacy. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions Long‐term work loss improved significantly in early RA randomized to infliximab+methotrexate or conventional combination therapy. No difference was detected between strategies, and the level of work loss days remained twice that observed in the general population. Trial Registration number: NCT00764725 This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion: We report the first epidemiological description of KFD in a population of sub‐Saharan origin. According to our data, this disease is present in the Black African diaspora and is strongly associated with autoimmune diseases, particularly lupus. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion: Over half of all persons with symptomatic knee OA are younger than 65 years of age. As many of these younger persons will live for three decades or more, there is substantially more time for greater disability to occur and policymakers should anticipate healthcare utilization for knee OA to increase further in upcoming decades. These data emphasize the need for the deployment of innovative prevention and treatment strategies for knee OA, especially among younger persons. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions: A simple definition of ‘self‐report of gout or urate‐lowering therapy use' has the best test performance characteristics of existing definitions that use routinely available data. A more complex combination of features is more sensitive, but still lacks good specificity. If more accurate case‐definition is required for a particular study, the 2015 ACR‐EULAR Gout Classification criteria should be considered. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions. IT was highly cost‐effective in the majority of scenarios. Although IE was more effective in five years, a substantial reduction in the cost of biologics was required in order for IE to become cost‐effective in early aggressive RA under willingness‐to‐pay thresholds that most healthcare settings may find acceptable. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion: Heterogeneity in methods used, the period or calendar year(s) for which the estimates were projected, and heterogeneity of variables evaluated led to disparate estimates, with results ranging from 0.7 to 3.5 rheumatologists per 100,000 population. An international initiative is needed to agree upon a common approach for a reliable estimation of manpower requirements in rheumatology. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion: The OTA procedure generated a valid short form of the CHFS with minimal loss of information compared to the full‐length form. The OTA method used was based on objective, pre‐specified criteria, but should be further studied for viability as a general procedure for shortening patient reported outcome measures in health research. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusion: CLE may be associated with an increased risk of CVA and PAD, but not IHD. Factors contributing to increase CVA risk in patients with CLE merit evaluation. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions: Our large multicenter study identified that the initial presentation of cSLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early‐onset and adolescent groups. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Conclusions. Specialty tier‐level cost sharing was associated with interruptions in RA biologic treatment among Medicare patients. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 24 Mar 2016 23:00:00 +0100Publication date: Available online 24 March 2016 Source:Best Practice & Research Clinical Rheumatology Author(s): Gaetane Nocturne, Divi Cornec, Raphaèle Seror, Xavier Mariette Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by dryness and systemic involvement in more than a third of the patients. Patient management has suffered from the lack of effective treatments. However, progresses made in the understanding of pSS pathogenesis have allowed a move to a more targeted approach to therapeutic intervention. Given the key role of chronic B cell activation, B cell-targeted therapies were the first candidate. New pathways are currently investigated including costimulation and ectopic germinal centre formation. In this review, we have summarized ...
Thu, 24 Mar 2016 23:00:00 +0100The objective of this study was to determine the effect of aging and oxidative stress on chondrocyte intracellular signaling, with a specific focus on oxidation of cytosolic PRX2 and mitochondrial PRX3. Menadione was used as a model to induce cellular oxidative stress. Compared with chondrocytes isolated from young adult humans, chondrocytes from older adults exhibited higher levels of PRX1–3 hyperoxidation basally and under conditions of oxidative stress. Peroxiredoxin hyperoxidation was associated with inhibition of pro-survival Akt signaling and stimulation of pro-death p38 signaling. These changes were prevented in cultured human chondrocytes by adenoviral expression of catalase targeted to the mitochondria (MCAT) and in cartilage explants from MCAT transgenic mice. Peroxiredoxin hyp...
Thu, 24 Mar 2016 23:00:00 +0100Conclusion Increased sternal uptake is significantly associated with CT structural abnormalities and knowledge of these non-neoplastic variants is essential for correct interpretation of SPECT/CT bone scans especially in patients with known cancers. (Source: The Egyptian Journal of Radiology and Nuclear Medicine)
Thu, 24 Mar 2016 23:00:00 +0100Publication date: 26 March–1 April 2016 Source:The Lancet, Volume 387, Issue 10025 Author(s): Boglarka Remenyi, Ahmed ElGuindy, Sidney C Smith, Magdi Yacoub, David R Holmes Acute rheumatic fever and rheumatic heart disease remain major global health problems. Although strategies for primary and secondary prevention are well established, their worldwide implementation is suboptimum. In patients with advanced valvular heart disease, mechanical approaches (both percutaneous and surgical) are well described and can, for selected patients, greatly improve outcomes; however, access to centres with experienced staff is very restricted in regions that have the highest prevalence of disease. Development of diagnostic strategies that can be locally and regionally provided and improve access...
Thu, 24 Mar 2016 23:00:00 +0100We describe both the common and less common etiologies of rapidly destructive arthropathy that one should consider, with imaging examples, and present discriminative factors when present. (Source: Current Problems in Diagnostic Radiology)
Thu, 24 Mar 2016 23:00:00 +0100CONCLUSIONS: ACT for osteoarthritis is likely to be an acceptable treatment option for people with osteoarthritis. Progress to a definitive trial is warranted. Rasch-transformed outcome scales are preferable in clinical trials where possible. Implications for Rehabilitation Acceptance commitment therapy (ACT) is an effective treatment for many pain conditions andcould be a useful intervention for people with osteoarthritis who have high levels of pain. Rasch analysis is a measurement technique that may enable greater precision in detectingmeaningful treatment effects in routine clinical outcomes. The ACT intervention was successful in reducing pain and sleep difficulties and there werenotable differences in effects between standard and Rasch-transformed scales. In a relatively small trial,...
Thu, 24 Mar 2016 21:51:02 +0100CONCLUSION: The AOS-Fr is a reliable and valid score equivalent to the English version in terms of psychometric properties, thus is available for use in multicentre trials. PMID: 27007093 [PubMed - as supplied by publisher] (Source: Canadian Journal of Surgery)
Thu, 24 Mar 2016 18:47:10 +0100Carestream Health said today it filed a 510(k) application with the FDA seeking clearance for its OnSight 3D Extremity System cone-beam based extremity CT imaging device. The Rochester, N.Y.-based company’s system is designed to provide high-quality, low-dose 3D imaging for use by orthopedic and sports medicine practices, hospitals, imaging centers, urgent care facilities and other healthcare providers. “Orthopaedic imaging is a major focus for Carestream because of the prevalence of musculoskeletal conditions among people of all ages. Youth and adults often suffer sports-related injuries to their knees, ankles and feet while older adults experience arthritis, joint instability, meniscus loss and other conditions. Our goal is to offer a compact, affordable imaging system that ...
Thu, 24 Mar 2016 15:57:16 +0100Exercise is the optimum way to manage low back pain, NICE experts have said in its latest draft guidance, which also downplays the use of paracetamol and retracts its endorsement of acupuncture. (Source: GP Online News)
Thu, 24 Mar 2016 15:22:43 +0100In Olmsted County, Minn., USA, reliable, population-based epidemiologic research studies can be performed because of a unique medical records linkage system, the Rochester Epidemiology Project (REP). Our objective was to summarize the epidemiologic data describing the prevalence of skin and skin-related diseases derived from the REP and to compare the findings with those from other studies worldwide. Retrospectively, we reviewed the results of population-based REP studies reporting the prevalence of skin and skin-related diseases over more than 4 decades and compared them to other published prevalences globally. Prevalences from the REP reported per 100,000 persons were as follows: hidradenitis suppurativa, 130.0; psoriasis, 700.0; psoriatic arthritis in 1992, 100.0, and in 2000, 160.0; Be...
Thu, 24 Mar 2016 15:22:23 +0100Abstract Many skin and skin‐related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin‐related diseases affecting males vs. females, we reviewed published population‐based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...
Thu, 24 Mar 2016 15:14:55 +0100Traditionally, the dental profession has primarily treated periodontitis using a mechanical/surgical, rather than a pharmaceutical, approach. However, based on experiments several decades ago which demonstrated that tetracyclines, unexpectedly, inhibit collagen‐ and bone‐destructive mammalian‐derived enzymes (e.g. the collagenases), and through non‐antibiotic mechanisms, the concept of host‐modulation therapy (HMT) was developed. Accordingly, two drug‐development strategies evolved: (i) the development of non‐antimicrobial formulations of doxycycline; and (ii) the chemical modification of tetracyclines to eliminate their antibiotic activity but retain (or even enhance) their anti‐collagenase properties. Regarding the latter, these chemically modified tetracyclines (CMTs) sh...
Thu, 24 Mar 2016 00:07:02 +0100Top Seattle pain clinic, Seattle Pain Relief, is now offering prescription pain creams for non-narcotic pain relief. The creams are covered by insurance and are great for arthritis, tendonitis,...(PRWeb March 23, 2016)Read the full story at http://www.prweb.com/releases/seattle-pain-clinic/prescriptionpaincream/prweb13286343.htm (Source: PRWeb: Medical Pharmaceuticals)
Thu, 24 Mar 2016 00:00:00 +0100Atypical clinical presentations associated with group W meningococcal disease (MenW) are well-described and include pneumonia, septic arthritis, endocarditis and epiglottitis/supraglottitis. Following anecdotal reports of teenagers presenting with predominantly gastrointestinal symptoms, we undertook a case review of MenW cases in 15 to 19 year-olds diagnosed in England between July 2015 and January 2016. Of the 15 cases, seven presented with a short history of nausea, vomiting and diarrhoea; five of these seven cases died within 24 hours of presentation to hospital. (Source: Eurosurveillance)
Wed, 23 Mar 2016 23:00:00 +0100In this study, we elucidated the roles of selected complement proteins in S. aureus septic arthritis. Mice lacking the complement component 3 (C3–/–), complement factor B (fB–/–), and receptor for C3-derived anaphylatoxin C3a (C3aR–/–) and wild-type (WT) control mice were intravenously or intra-articularly inoculated with S. aureus strain Newman. The clinical course of septic arthritis, as well as histopathological and radiological changes in joints, was assessed. After intravenous inoculation, arthritis severity and frequency were significantly higher in C3–/– mice than in WT controls, whereas fB–/– mice displayed intermediate arthritis severity and frequency. This was in accordance with both histopathological and radiological fi...
Wed, 23 Mar 2016 23:00:00 +0100Abstract Cataract is one of the most common and visually debilitating complications of pediatric uveitis. It develops as a consequence of chronic inflammation and steroid use and is seen most often in juvenile idiopathic arthritis (JIA)-associated uveitis. Cataract extraction with intraocular lens (IOL) insertion has been carried out with a measure of success in non-uveitic pediatric eyes, but in cases of uveitis, multiple factors affect the final outcome. Chronic inflammation and its sequelae such as band keratopathy, posterior synechiae, and cyclitic membranes make surgical intervention more challenging and outcome less certain. Postoperative complications like increased inflammation, glaucoma, posterior capsular opacification, retrolental membranes, and hypotony may compromise...
Wed, 23 Mar 2016 23:00:00 +0100(Source: Rheumatology International)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionIndividuals with RA are mostly active at very light and light intensities. PA at these intensity levels associates favorably with cardiovascular markers and lower disability and disease activity in RA. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionThe overall 12‐year drug survival rate was 23.4%, being significantly higher for etanercept than adalimumab and infliximab. Etanercept discontinuations for inefficacy did not increase from 3 to 12 years. Concomitant MTX increased adalimumab and etanercept drug survival. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionOur data demonstrate that the high levels of circulating IFI16 in RA are more frequent in RF/anti‐CCP–positive RA patients and significantly associated with pulmonary involvement. The relevance of circulating IFI16 protein as a new clinical biomarker of RA should be verified with additional studies. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionAt 5 years after THA, the control group had caught up with the training group on physical functioning, and the participants led an active lifestyle. Those with worse preoperative scores on pain and physical functioning in sport were at risk of being less physically active in the long term following THA. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionBecause of high heterogeneity across studies and within study populations, no conclusions can be drawn with regard to the course of pain and physical functioning. These findings support current research efforts to define subgroups or phenotypes within knee OA populations. Strong evidence was found for knee characteristics, clinical factors, and psychosocial factors as prognostics of deterioration of pain and physical functioning. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionThis economic evaluation from a societal perspective showed that a nonpharmacologic, face‐to‐face treatment program for patients with GOA was likely to be cost effective, relative to a telephone‐based program. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionBody composition, sex hormones, and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and/or fibrinogen. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionIncreased FMI, but not body mass index, FFMI, or TNF or IL‐6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionOpen‐label epratuzumab treatment was well tolerated for up to 3.2 years, and associated with sustained improvements in disease activity and HRQOL, while steroids were reduced. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionAlthough WD was already prevalent at inclusion in the cohort, a substantial proportion of patients incurred further adverse work outcome over 12 years. In addition to country of residence, uveitis, age, and self‐reported physical function or disease activity predicted long‐term adverse work outcome. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100ConclusionGreater amounts of both visceral fat and liver fat were independently associated with hyperuricemia. (Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100(Source: Arthritis Care and Research)
Wed, 23 Mar 2016 23:00:00 +0100This study evaluated consistency between the PNG Adult STGs (2003 and 2012) and those for children (2005 and 2011) with respect to the MDCs (2002, 2012) for six chronic and/or acute diseases: asthma, arthritis, diabetes, hypertension, pneumonia and psychosis. Additionally, the potential impact of prescriber level restrictions on rational medicines use for patient’s living in rural areas, where no medical officer is present, was evaluated. Almost all drugs included in the STGs for each disease state evaluated were listed in the MDCs. However, significant discrepancies occurred between the recommended treatments in the STGs with the range of related medicines listed in the MDCs. Many medicines recommended in the STGs for chronic diseases had prescriber level restrictions hindering acce...
Wed, 23 Mar 2016 23:00:00 +0100Publication date: Available online 24 March 2016 Source:Chemico-Biological Interactions Author(s): Gopenath Thangaraj, Vadim Manakov, Aljona Cucu, Claudia Fournier, Paul G. Layer As a means to analyse anti-inflammatory effects by radiation and/or by cholinergic mechanisms, we found that cultured primary human osteoblasts express most cholinergic components. After X-ray irradiation, their level of acetylcholinesterase (AChE) was strongly elevated. As a 3D model, we cultured mesenchymal stem cells isolated from E11 mouse embryos as micromass nodules, and differentiated them into chondro- and osteoblasts. They were stimulated by 5 or 10 ng/ml of the inflammatory cytokine TNF-α to mimic an inflammatory condition in vitro, before exposure to 2 Gy X-rays. Effects on chondro- and osteobla...
Wed, 23 Mar 2016 23:00:00 +0100Fellowship for veterinary peer Professor the Lord Trees has been elected to the Fellowship of the Royal Society of Edinburgh (RSE). The Fellowship comprises more than 1600 individuals from Scotland, the UK and further afield and enables the RSE to provide a wide range of leadership and expertise in supporting the advancement of knowledge and learning in Scottish public life. EBVM resource RCVS Knowledge has launched Veterinary Evidence, an online resource aimed at those interested in promoting and using the principles of evidence-based veterinary medicine (EBVM) within practice. RCVS Knowledge says the portal, at www.veterinaryevidence.org, will provide access to a wide range of materials to support EBVM and that, in time, it will expand to include forums and other resources. Dogs needed f...
Wed, 23 Mar 2016 23:00:00 +0100We have greatly enjoyed reading the recently published article by Noseworthy et al. entitled “Comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease” . The authors conducted a retrospective analysis of administrative data in the U.S. and found that non-vitamin K antagonist oral anticoagulants (NOACs) are effective and safe in patients with post-surgical (valve repair or bioprosthetic valve replacement) or native (rheumatic mitral stenosis, non-rheumatic mitral stenosis, and either mitral regurgitation, aortic stenosis, or aortic insufficiency) valvular heart disease. (Source: International Journal of Cardiology)
Wed, 23 Mar 2016 23:00:00 +0100Authors: Vega-Morales D, Esquivel-Valerio JA, Garza-Elizondo MA PMID: 27011325 [PubMed - as supplied by publisher] (Source: Reumatismo)
Wed, 23 Mar 2016 23:00:00 +0100CONCLUSION: This study suggests some efficacy of abatacept in patients with refractory disease in routine clinical practice, particularly in the case of articular manifestations, with an acceptable safety profile. These data support conducting new controlled trials of abatacept in SLE patients. PMID: 27013663 [PubMed - as supplied by publisher] (Source: Lupus)
Wed, 23 Mar 2016 23:00:00 +0100CONCLUSION: This analysis highlights diagnostic challenges in LN in Africa and shows that a CYC/glucocorticoid-based regimen remains the standard of treatment for adult patients. The contributions of this therapy to reported outcomes of LN in Africa require further exploration. PMID: 27013662 [PubMed - as supplied by publisher] (Source: Lupus)
Wed, 23 Mar 2016 23:00:00 +0100Lung cancer is the leading cause of cancer deaths in the U.S. But, lung cancer is not one size fits all. There are variations in the disease that make some cases harder to treat than others. In a laboratory setting, Mayo Clinic researchers have found that a combination of a drug used to treat rheumatoid [...] (Source: News from Mayo Clinic)
Wed, 23 Mar 2016 21:38:17 +0100BOSTON (CBS) – Doctors at Boston Children’s Hospital are repairing ruptured ACLs with a less invasive procedure, and they think it could change the course of treatment. Corey Peak of Cambridge took a nasty tumble on the ski slopes last January. “I heard two pops while I was falling,” Peak explains. “One was my right ski binding coming undone which is good because it helps protect the knee. But the other side I think was my right ACL rupturing.” Peak is among hundreds of thousands of people who tear their ACLs every year. Girls who play sports like soccer, basketball, lacrosse and field hockey are most at risk. Many require ACL reconstruction surgery where a tendon graft is used from another part of the knee. That means patients have to recover from the ACL tear and the graft....
Wed, 23 Mar 2016 21:28:23 +0100WASHINGTON – Fear of falling at 12 weeks was associated with poorer functional recovery up to 1 year after hip fracture, particularly if the person had a high level of function before the fracture, a... (Source: Rheumatology News)
Wed, 23 Mar 2016 20:58:42 +0100AUSTIN, TEX. – Using the federal government’s voluntary self-disclosure protocol to report potential program violations offers advantages and disadvantages. On one hand, the protocol allows health... (Source: Rheumatology News)
Wed, 23 Mar 2016 19:18:41 +0100Researchers have uncovered a metabolic defect that spurs T cells to go rogue in rheumatoid arthritis patients. (Source: ScienceDaily Headlines)
Wed, 23 Mar 2016 18:41:02 +0100Authors: Giacomelli R, Ruscitti P, Alvaro S, Ciccia F, Liakouli V, Di Benedetto P, Guggino G, Berardicurti O, Carubbi F, Triolo G, Cipriani P Abstract Although in the past the prevention of joint destruction in rheumatoid arthritis (RA) was strongly emphasized, now a great interest is focused on associated comorbidities in these patients. Multiple data suggest that a large percentage of RA patients are affected by Type 2 Diabetes (T2D), whose incidence has reached epidemic levels in recent years, thus increasing the health care costs. A better knowledge about the pathogenesis of these diseases as well as the mechanisms of action of drugs may allow both policy designers and physicians to choose the most effective treatments, thus lowering the costs. This review will focus on the rol...
Wed, 23 Mar 2016 17:00:57 +0100
Wed, 23 Mar 2016 14:45:02 +0100In conclusion, the present study demonstrated that, while MTX therapy effectively reduced D-dimer levels, addition of etanercept to the treatment regimen was required to achieve a long-lasting remission of clinical symptoms, including fever. PMID: 26998032 [PubMed - as supplied by publisher] (Source: Experimental and Therapeutic Medicine)
Wed, 23 Mar 2016 12:00:00 +0100Conclusion This small laboratory study points to specific biological mechanisms that might explain why women are more likely to suffer autoimmune disorders, such as SLE, than men. It found the second silenced copy of the X chromosome in women can be partially reactivated and express immune-related genes, instead of staying completely silent. Though this is a plausible reason for the overactive immune system found in SLE, it does not explain why men can also have the condition. Also, only SLE was investigated in this study and with blood samples from just five children with the condition. It is not clear at this stage how these findings fit into the cause of SLE and whether similar mechanisms are at play for other autoimmune disorders. There are other nuances in the results that mean thi...
Wed, 23 Mar 2016 10:23:04 +0100With projects submitted from Scotland to Togo, the 2016 eyeforpharma Barcelona Awards were truly a global occasion. Although we had wide participation from pharma’s top 20 (18 out of 20 to be exact, we’ll get the full set in 2017), UCB once again stood out from the pack. 2016 marked the second consecutive year in which they have taken home two awards; this time in the ‘Most Valuable Pharma Collaboration’ and ‘Customer Innovator’ categories. Many entrants had a strong technology component, with patient support and HCP education apps, tech-inspired hackathons, and the first social network for physicians. We also saw a huge increase in collaborations across industry and sectors. Projects embraced the wisdom of the crowd, with contributions from HCPs, nurses, advocacy groups, minis...
Wed, 23 Mar 2016 09:24:03 +0100Erratum to "Risk Factors for Osteoarthritis and Contributing Factors to Current Arthritic Pain in South Korean Older Adults" by Lee KM, et al. (Yonsei Med J 2015;56:124-31.). Yonsei Med J. 2016 May;57(3):806 Authors: Abstract [This corrects the article DOI: 10.3349/ymj.2015.56.1.124.]. PMID: 26996587 [PubMed - as supplied by publisher] (Source: Yonsei Medical Journal)
Wed, 23 Mar 2016 06:22:11 +0100Abstract The aim of the study was to assess drug levels, immunogenicity and sacroiliitis on MRI in patients with axial spondyloarthritis under biologic tapering strategy. Consecutive patients with axial spondyloarthritis who remained in low disease activity more than 1 year after dose tapering of infliximab and adalimumab were included. Plasma drug concentrations of TNF inhibitors and anti-drug antibodies were determined, and MRI of sacroiliac joints was evaluated. Of twenty patients included, eighteen had therapeutic drug levels, no patient had anti-drug antibodies, and no patient had active sacroiliitis on MRI. These data could support the biologic tapering strategy and their maintenance over time. (Source: Rheumatology International)