Last Build Date: Tue, 22 Mar 2016 08:28:12 +0100
Tue, 22 Mar 2016 08:07:51 +0100In 2012, an 84-year-old Chinese man presented with progressive, chronic left atraumatic knee pain and swelling. His medical history was notable for pulmonary tuberculosis treated in China in 1951 and rheumatoid arthritis diagnosed in 2006. His joint pain progressed despite use of disease modifying drugs and steroid injections. Antitumor necrosis factor inhibitors were not used because of concerns of tuberculosis reactivation. Clinical examination showed he had antalgic gait, knee effusion, stiffness, and joint-line tenderness. (Source: The Lancet Infectious Diseases)
Mon, 21 Mar 2016 21:28:41 +0100Most pets in the U.S. today are overweight or obese. According to the most recent information from the Association for Pet Obesity Prevention (APOP), over half of U.S. dogs are overweight, and almost 60 percent of cats are as well. Obesity is its own disease, and it's also the root cause of several other painful, debilitating diseases including hip dysplasia, arthritis, diabetes, hypertension, respiratory problems, kidney disease, and a significant reduction in both quantity and quality of life. While most dog guardians can think of several ways to help their pet get physically fit, people who share their lives with a corpulent cat often have no idea how to get beefy Bella to follow a workout routine. Here are my favorite recommendations for getting the overweight feline in your life up an...
Mon, 21 Mar 2016 20:36:21 +0100Antisclerostin monoclonal antibodies have shown their ability to increase bone density in phase II and III trials of men and women with osteoporosis but could potentially have the opposite effect in... (Source: Clinical Endocrinology News)
Mon, 21 Mar 2016 05:00:00 +0100Updated Date: Mar 21, 2016 EST (Source: DailyMed Drug Label Updates)
Sun, 20 Mar 2016 18:07:33 +0100Purpose: Self-reported pain questions are the established way to determine osteoarthritis (OA) related pain in population cohort studies, of which NHANES-type (National Health Nutrition Examination Survey) questions and WOMAC (Western Ontario and McMaster Universities Arthritis Index) are the most common. However, there is limited understanding of how wording variations relating to the duration of pain (i.e. most days in the month) and period of pain recall (i.e. in the last year) affect the prevalence and comparability of these questions. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:33 +0100Resolving inflammatory exudates produce chemical mediators that regulate inflammation, stimulate resolution and tissue regeneration. These mediators include the lipoxin, resolvin, protectin and maresin families and are collectively called specialized pro-resolving mediators. Identification of novel signals in these processes and their pathways is of interest. These mediators actively regulate leukocyte responses counter-regulating the production pro-inflammatory signals, promoting their differentiation to a protective phenotype and orchestrating their trafficking in and out of injured tissues. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Quadriceps and hamstring muscle co-contraction prior to and following heel-strike in gait is a commonly observed strategy of the injured, arthritic and post-surgical knee joint. Previous work applied Wavelet Analysis (WA) and Support Vector Machine tools to identify temporal alterations in multi-muscle activity patterns for female patients with a total knee arthroplasty (TKA) for end-stage osteoarthritis. Distinct alterations of high-intensity activation peaks of vastus medialis (VM) and biceps femoris (BF) were observed indicating a delayed activation onset and shift toward a common muscle activation post heel-strike in TKA subjects. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Connexins, the major proteins of gap junctions, are expressed in various cell types and are important in the key process of intercellular communication. Connexins 26, 32 and 43 are expressed in synoviocytes, and connexin 43 (Cx43) is the most highly expressed connexin in normal human synovial membranes. Cx43 regulates immunological response in several tissues such as kidneys and lungs. Although, the role of Cx43 in synovium of arthritis is almost unclear. The aim of this study is to examine the expression level of Cx43 gene in synovial tissue in patients with rheumatoid arthritis (RA) compared with osteoarthritis. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Post-traumatic arthritis (PTA) is a frequent and clinically important complication of joint injury. While PTA can occur rapidly after moderate to severe articular fractures, not every patient will develop this condition. There are currently no effective screening methods to determine who is at risk for developing PTA. The overall objective of this study was to identify biomarkers following articular fracture that may be associated with joint injury and predictive of the development of PTA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: YKL-40 is associated with inflammation and tissue injury in diseases such as asthma and rheumatoid arthritis. It has been shown to be produced by macrophages and some tissue cells as well as by cancer cells. Increased circulating YKL-40 levels have been reported in patients with osteoarthritis (OA). However, the role of YKL-40 in OA joints remains largely unknown. In the present study, we investigated the levels of YKL-40 in simultaneously collected plasma, synovial fluid (SF) and cartilage samples from OA patients undergoing knee replacement surgery, and investigated its associations with inflammatory factors and matrix degrading MMP enzymes in an attempt to understand the role of YKL-40 in OA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Collagen isomerization is a non-enzymatical process associated with tissue aging, and changes in levels of isomerized peptide fragments may reflect unique changes during pathological conditions. The D-G sequence in the collagen type II neoepitope C2M is likely to undergo beta-isomerization over time, and may be altered in tissue turnover in diseases affecting the joint. We therefore hypothesize that pathological conditions, such as osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS), in which the anabolic/catabolic balance of cartilage is challenged, may result in altered levels between isomerized and normal collagen type II. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Osteoarthritis (OA) fits the description provided by Machiavelli over 500 years ago of a malady, in the beginning “is easy to cure but difficult to detect, but in the course of time, not having been either detected or treated in the beginning, becomes easy to detect but difficult to cure”. A precedent for improved outcomes with early identification and early treatment now exists for Rheumatoid Arthritis. We hypothesized that this paradigm should inform the approach to the diagnosis and treatment of OA in order to prevent the disease prior to the onset of irreversible joint tissue pathology. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Periostin is a secreted extracellular matrix protein which belongs to the fasciclin family. It plays a role in embryogenesis and tissue repair and shows increased expression in tissues subject to mechanical stress and in some neoplastic and inflammatory conditions. Periostin has been identified in synovium and cartilage in osteoarthritis (OA) and in inflammatory arthritis synovium. To determine the role of periostin in inflammatory OA and non-inflammatory OA we characterized periostin expression in the synovium and synovial fluid in cases of non-inflammatory and non-inflammatory OA and in normal and rheumatoid arthritis (RA) synovium. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100In this study, we sought evidence for a possible role of these cells in OA by quantifying and characterizing mast cells in the osteoarthritic (OA) synovium using immunofluorescence and investigating their association with clinical parameters in comparison with rheumatoid arthritis (RA) samples. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Anti-inflammatory treatment of osteoarthritis (OA) or rheumatoid arthritis (RA) using non- steroidal anti-inflammatory drugs (NSAID) as well as glucocorticoids (GC) is supposed to negatively influence bone metabolism and healing. However, studies addressing the number of afflicted patients and indicating the negative impact of comorbidities or even standard medications such as the impact of NSAID as well as GC on the bone fracture healing process, especially the initial phase, are scarce. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Obesity is one of the most modifiable risk factors for symptomatic knee osteoarthritis (OA), and dietary induced weight loss combined with exercise is potentially the best non-pharmacologic treatment for OA symptoms. In an exploratory analysis of the previously published Intensive Diet and Exercise for Arthritis (IDEA) trial, we test the hypothesis that intensive dietary induced weight loss, either with or without exercise, will significantly change the gait of older, overweight and obese adults with knee OA compared to exercise alone. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Clinical management of chronic joint pain evoked by osteoarthritis is a real challenge due to our limited understanding of the cellular mechanisms that initiate and develop chronic pain. It has been increasingly recognized that glial cells, such as microglia and astrocytes in the central nervous system play an important role in the development and maintenance of chronic pain. Notably, astrocytes make very close contacts with synapses and astrocyte reaction after nerve injury, arthritis, and tumor growth is more persistent than microglial reaction and displays a better correlation with chronic pain behaviors. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Exercise and weight loss have been shown to reduce pain and improve function in overweight and obese adults with knee OA. Results from the Intensive Diet and Exercise for Arthritis (IDEA) trial, an 18-month trial comparing dietary-weight loss (Diet,D) and Diet plus Exercise (D+E) to an Exercise only control group (E), also found a significant reduction in knee compressive forces in the D group and in plasma levels of IL-6 in the D and D+E groups compared to the E control group. The purpose of the present study was to determine the effects of these interventions on biomarkers reflecting interstitial matrix turnover and tissue inflammation as a proxy for effects on joint structure and determine the association of biomarkers with selected clinical outcome measures including radiograp...
Sun, 20 Mar 2016 18:07:32 +0100Purpose: Progranulin (PGRN) is a multifunctional growth factor which is composed of seven-and-a-half repeats of a cysteine-rich motif in the order P-G-F-B-A-C-D-E. PGRN directly binds to TNF-α receptors (TNFR), and inhibits TNF-α activity. Atsttrin(A50), an engineered protein composed of three PGRN fragments (1/2F-1/2A-1/2C), exhibited selective TNFR binding, and potently prevented inflammation in multiple arthritis mouse models (Tang, et al, Science, 2011). In addition, recent studies demonstrated that local injection of PGRN significantly prevented OA progression (Zhao et al, Annals of the Rheumatic Diseases, 2015). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:31 +0100Purpose: The Arthritis Foundation initiated this demonstration project with the long-term goal of implementing an innovative big data approach to recruitment for osteoarthritis (OA) clinical trials. A major challenge in OA clinical trials is correctly classifying the OA phenotype for each patient. This abstract describes the first step in this project: to identify and validate a large cohort of OA patients. The data were obtained from the national clinical repository from the Veterans Health Administration (VHA). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:31 +0100Purpose: Osteoarthritis (OA) is generally regarded by physicians and the public as a less severe problem than rheumatoid arthritis (RA). However, the costs of OA and RA have each been found to account for about 1% of the US gross domestic product, explained in part by the higher prevalence of OA vs RA. Nonetheless, the standardized mortality ratio (SMR) (which is independent of prevalence) for OA is reported as 1.55, and quite similar to the SMR for RA of 1.5–1.6. Therefore, the morbidity and mortality of OA appear underestimated. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:31 +0100Purpose: Osteoarthritis (OA) is the most common form of arthritis and one of the major causes of disability in the elderly. The current focus in OA research and clinical practice is on persons with radiographic symptomatic disease. This is the very end-stage of the disease process, and hence modern therapies are largely palliative and only modestly effective. This reinforces the need for targeted interventions in early OA or even before development of symptoms to develop preventive strategies. We aimed to develop and validate a prognostic model for incident hip osteoarthritis (HOA) in a general population and determine the value of different risk factor groups (i.e., anthropometric/demographic characteristics, routine physical/laboratory exams, imaging risk factors, biochemical marker of u...
Sun, 20 Mar 2016 18:07:31 +0100Purpose: Osteoarthritis (OA) is a chronic disease and the most prevalent form of arthritis. It is a major cause of pain and disability that globally affects millions of individuals. In last years, differents phenotypes have been described; the most consistent are: biomechanics, genetic, inflammatory, metabolic, and pain. In US population metabolic syndrome (MetS) is more prevalent in patients with OA (59%) vs. population without OA (23%),; on the other hand, inflammation has been described as an important risk factor in the development and progression of knee OA (KOA). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:31 +0100Purpose: Several international guidelines recommend intra-articular (IA) corticosteroid injections for patients with hip OA experiencing moderate to severe pain and no responding to oral analgesics. However, injection into the hip joint is challenging and needs ultrasound or fluoroscopic guidance. This makes it almost impossible in general practice. Moreover, an IA injection can lead to septic arthritis. An IA injection in the year preceeding total hip replacement increases the risk of infection leading to early revision surgery. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:31 +0100Purpose: Cartilage consists of numerous glycoproteins and proteoglycans, which are of significance for its functionality. In osteoarthritis (OA), we previously observed an altered glycophenotype of cartilage and chondrocytes. We also examined the presence of galectins and found that Galectin-1 (Gal-1) predominantly accumulated in regions of severely degenerated cartilage. The interaction of glycans and galectins is crucial in many physiological or pathological processes. While a protective role of Gal-1 is described in rheumatoid arthritis (RA), little is known about the role of galectins in onset and progression of OA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:31 +0100Purpose: Galectin-3 (Gal-3) is a carbohydrate-binding protein that has been implicated in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). However, whereas Gal-3 has been congruently shown to induce deleterious effects including joint inflammation and bone erosion in RA, conflicting results exist regarding the precise role of Gal-3 in OA. As such, a protective role of Gal-3 has been suggested based on data from animal models and human OA chondrocytes, but intra-articular injection of Gal-3 in mice induced joint swelling and lesions, and Gal-3-treated OA chondrocytes responded with up-regulated MMP3 and ADAMTS5 mRNA levels. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: Osteoarthritis (OA) is the most common arthritis worldwide and the most debilitating factor in OA is pain. Pain in OA is likely to be multifactorial, with features of nociceptive and mechanical pain elements. Recent work has suggested that pain ‘sensitization’ is also a feature of OA pain. ‘Sensitization’ is described as the phenomenon of heightened pain perception, mediated by increased firing of peripheral nociceptors, which may be experienced by a person at a local site related to damage or injury, also known as peripheral sensitization. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: Diet and exercise intervention beneficially affects knee joint loading, systemic inflammation and pain in knee OA. Further, this intervention reduces infrapatellar fat pad (IPFP) volume, a potential contributor to intra-articular inflammation and pain. Measurement of the total IPFP volume, however, is time consuming. Yet it is uncertain, whether changes in the IPFP preferentially occur in peripheral or central locations. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: Osteoarthritis is the most common arthritis and is a major public health problem. Optimal management requires that consumers actively participate in care. Gaining insight into consumer perceived needs of osteoarthritis health information may help health care providers and organisations develop appropriate management systems to improve the care of people with osteoarthritis. The aim of this review was to summarise evidence from studies evaluating patient perceived needs of health information relating to osteoarthritis care. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: The treatment of rheumatoid arthritis (RA) is directed to reduce/eliminate inflammation and prevent secondary osteoarthritis (OA) damage. However, remission or even low disease activity is unusual in 50% of RA patients at this time, despite advances in therapy. One partial explanation may relate to clinically important secondary OA. In one study, about 20% of RA patients with high index scores whose therapy was not intensified had clinically important OA. We analyzed physician estimates of inflammation and secondary OA damage in RA patients in two ways: a) quantitative physician 0–10 visual analog scales (VAS) for inflammation (DOCINF) and damage (DOCDAM), and b) estimates of the proportion(s) of clinical management decisions attributable to inflammation, damage, and/or distress...
Sun, 20 Mar 2016 18:07:30 +0100Purpose: Osteoarthritis (OA) of the knee is the most common form of disabling arthritis. Up to 50% of people in the US develop OA by age 85. Physical activity, weight loss, and medical management are effective, low-cost means for managing early knee OA but integration of these approaches into routine clinical care lags. Use of Decision Aids (DAs) and Shared Decision Making (SDM)—defined as “an approach where clinicians and patients share the best available evidence ⋯ and patients are supported to consider options to achieve informed preferences” may improve health outcomes in patients with early knee OA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: Osteoarthritis (OA) is the most common degenerative arthritis, a type of arthritis that is caused by breakdown of articular cartilage with eventual loss of the cartilage of the joints. Smad3 is a key intracellular messenger in the transforming growth factor β signaling pathway. Previous study suggested Smad3 gene mutation is a possible predisposing factor for human OA and found gene mutation in OA, providing insight into the function of SMAD3 mediated TGF-b signals in the development of OA and also suggested that Smad3 gene mutation may be a risk factor for genetic susceptibilities to OA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: To describe and to evaluate the clinical and epidemiologic features of hand and knee Osteoarthritis (OA) in Mexico from the Mexican Initiative of Patients with Osteoarthritis and Rheumatoid Arthritis (IMPACTAR). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: Osteoarthritis (OA) is the most common form of arthritis associated with aging in humans and a leading cause of pain and disability. No disease-modifying drug is currently available and no major drug target has been identified. With the increased burden of OA in the aging population in many countries, a disease-modifying drug is needed. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: Skeletal muscle mass is a consequence of the balance between anabolic and catabolic processes. Sarcopenia is a common comorbidity of osteoarthritis (OA) and is primarily attributed to age and inactivity, with a subsequent reduction in the anabolic pathway. However, the catabolic impact of chronic, low-grade inflammation is less known. Our aim was to evaluate the pathogenic mechanisms of sarcopenia secondary to systemic inflammation in a chronic arthritis frame. For this purpose, we characterise alterations to muscle structure and gene expression in an animal model of chronic inflammatory arthritis. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: TissueGene-C (InvossaTM) is a novel gene and cell therapy for osteoarthritis (OA). The phase II human clinical studies showed that InvossaTM improved pain, sport activities and structural changes of cartilage in patients with OA. However, the exact mechanism underlying how InvossaTM works has not been revealed. Here we hypothesized that treatment of InvossaTM may induce an anti-inflammatory environment, especially M2 macrophage, which leads to the reduction of the pain and cartilage regeneration. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: Glycosylated proteins are essential components of the cartilage extracellular matrix and contribute to maintain the cartilage structure and function. A notable shift from glycoproteins containing α-2,6-linked sialic acids to those containing α-2,3-linked sialic acids has been associated with the onset of disorders such as rheumatoid arthritis (RA) and OA that concur with progressive cartilage degeneration. Here we studied the effects of the Maackia amurensis seed lectin (MASL) on chondrocytes and cartilage integrity from healthy donors, OA patients and animal models of arthritis (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: Microsomal PGE synthase-1 (mPGES-1) is a terminal enzyme in the production of prostaglandin E2 (PGE2), and its expression is upregulated during inflammation. mPGES-1 is considered as a potential drug target for the treatment of (osteo)arthritis and related diseases, in order to reduce adverse effects related to the current non-steroidal anti-inflammatory drugs (NSAIDs): Compounds which inhibit mPGES-1 expression or activity would have similar therapeutic effect as NSAIDs through decreasing inflammation-associated PGE2 synthesis. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: Osteoarthritis (OA) is one of the most common diseases, with a prevalence of about 10% in people aged 60 and over, leading to joint pain and disability. The pathophysiology is characterized by degradation of various components of extracellular matrix (ECM), above all collagen II and aggrecan, eventually causing a progressive loss of cartilage and bone. Therapeutic approaches to halt disease progression are non-existent. In contrast to rheumatoid arthritis (RA), inflammatory processes were considered as a secondary phenomenon. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: While osteoarthritis (OA) has traditionally been regarded as a non-inflammatory type of arthritis, there is growing evidence showing that the clinical course of OA may be driven by systemic and local inflammations. However, the role of inflammation in causing the subchondral bone pathology of OA is still unclear and there is no evidence on the association of inflammatory cytokines and with knee bone marrow lesions (BMLs). The aim of this study, therefore, was to describe the longitudinal associations between serum levels of interleukin (IL) - 6, IL-17A, IL-17F, IL-23 and knee BMLs in patients with knee OA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: Intra-articularly injected monosodium iodoacetate (MIA) induces joint pathology mimicking osteoarthritis (OA) and it is a widely used experimental model of OA. MIA injection induces an acute inflammation, which is followed by the development of cartilage degradation and joint pain. The early phase of MIA-induced inflammation is characterized by changes in cell metabolism and release of reactive oxygen species but the detailed mechanisms related to the onset and progression of the inflammatory response and (osteo)arthritis remain mostly unknown. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Effective treatment strategies for people with pre-arthritic hip disorders (PAHD) are needed to improve function and prevent or delay the onset of hip osteoarthritis. Previously, we completed an exploratory treatment trial to assess the effectiveness of movement pattern training (MPT), a rehabilitation approach to reduce hip adduction during functional tasks, for people with PAHD. To understand better the factors associated with treatment outcomes, we performed a secondary analysis to determine the association among mechanical factors and treatment outcomes among those who participated in MPT. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Osteoarthritis (OA) is the most common form of arthritis, and an estimated 9 million Americans suffer from symptomatic knee OA. These patients often have widely varying symptomology. Typically, these patients are initially treated with noninvasive treatments such as exercise, physical therapy, and/or a knee brace. Often, these treatments only temporarily delay the onset of more severe OA, and surgery is frequently required to best restore joint function. However, such surgeries, including total knee replacement (TKR), are sporadically effective in improving joint function and/or alleviating joint pain. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Pain is the most predominant symptom in osteoarthritis, however the underlying mechanisms are poorly understood. The synovium is a rich source of mediators that play a role in osteoarthritis and changes in synovitis have been associated with fluctuation of knee pain. In rodent models of rheumatoid arthritis and osteoarthritis the pro-inflammatory cytokine granulatocyte macrophage-colony stimulating factor (GM-CSF) has been identified as important mediator of inflammatory synovitis and pain. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Osteoarthritis (OA) is the most prevalent arthritis worldwide. The chronic nature of OA often leads to long-term disability, with pain being a major symptom for which people seek care. During established OA disease, chronic pain due to cartilage, synovial and bone damage may be aggravated by the process of “central sensitization”, whereby pain processing pathways in the central nervous system (CNS) become sensitized to peripheral nerve stimulation caused by degenerative and inflammatory disease processes. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: An MDHAQ/RAPID3 (Multidimensional Health Assessment Questionnaire/Routine Assessment of Patient Index Data) is a 2 sided, 1 page questionnaire which is completed by patients in 5–10 minutes, while waiting to see the doctor in the waiting room in routine clinical care. RAPID3 is an index which is informative in osteoarthritis (OA), rheumatoid arthritis (RA) and other rheumatic diseases. MDHAQ also includes a 0–10 visual analog scale for fatigue and a 60-symptom checklist, which may provide clues to recognize comorbid fibromyalgia (FM). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Clinical trials measure many outcomes which cover different manifestations of a given disease. In some diseases (e.g., rheumatoid arthritis) composite outcomes, constructed from a combination of measures, are used rather than one selected single outcome. Composite outcomes may be advantageous: Clinically, they better capture the change produced from the application of a treatment across several outcomes. Statistically, including more of the outcomes which produce a ‘signal’ may prove more sensitive to detecting a true treatment effect. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: In a rat monoiodoacetic acid (MIA)-induced arthritis model, the amount of MIA commonly used can be too high, resulting in rapid bone destruction. Here, we examined the effect of MIA concentrations on articular cartilage and the infrapatellar fat pad (IFP). We also established an original scoring system for macroscopic cartilage, bone and histologic IFP features specific to the rat MIA-induced arthritis model(Figure1B, Figure2, Figure3). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Osteoarthritis (OA) is the most common form of arthritis and is associated with chronic pain and reduced mobility. There is controversial evidence regarding the relationship between mechanical loading and OA. Specifically related to exercise, some studies have found a detrimental link between them, but others refute such a link, and suggest that exercise is an approach to prevent OA. Walking is known to put mechanical loads on the knee, and thus, brisk high mileage walking has been thought to be a good model to test the hypothesis that mechanical loading results in development and progression of knee OA in an otherwise healthy joint. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:27 +0100Purpose: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used to treat inflammation and its associated pain through reduction of prostaglandin E2 (PGE2) produced by cyclooxygenase (COX). However, systemic administration of NSAIDs often exhibit side effects, such as gastrointestinal disorders. External medication of NSAIDs by transdermal patch method has been used to reduce the side effects. In external medication of NSAIDs, penetrations of active ingredient into synovial tissue are essential for therapeutic efficacy. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:27 +0100Purpose: Non-pharmacologic strategies make an important contribution to the management of osteoarthritis in the community, but relatively little is known about the use of these therapies and how this varies by age and over time. Rehabilitation therapies, such as physical therapy and chiropractic, have been shown to improve the management of arthritis, and there is evidence also for the benefit of acupuncture and massage therapy. The purpose of this study was, for people with arthritis, a) to compare the age-trajectories of use of physiotherapy, chiropractic and complementary and alternative medicine (CAM) over 18 years by birth cohort and b) to determine how these trajectories are affected by socio-economic status (SES), lifestyle factors, and reported pain. (Source: Osteoarthritis and Car...
Sun, 20 Mar 2016 18:07:27 +0100Purpose: The purpose of the study was to verify the efficacy of an 8-week course of manualized Swedish massage, at an optimized dose, as well as to assess a maintenance dose, for reducing pain and increasing function compared to an active (light touch bodywork) control, and passive (usual care) control, in 222 adults with osteoarthritis (OA) of the knee. Detailed, protocolized cost-accounting was also an aim of the study. Although a formal cost-effectiveness study was beyond the scope of this research, this study allowed for the collection of robust data, using validated questionnaires and diaries to capture relevant cost, benefit, and quality-of-life data to be used in a future, formal cost-effectiveness trial. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:27 +0100Purpose: Osteoarthritis (OA) is the most common type of arthritis among older adults. In addition to using medical treatment for suppressing the symptoms and the inflammation, exercise is often recommended as a first-line intervention approach for OA and yet the optimal type has not been determined. Yoga is a mind-body intervention that is commonly used for promoting flexibility, muscle strength and relaxation. It has been proven to be a safe and feasible intervention for older adults with OA. The purpose of the study was to compare the effects of yoga and aerobic/strengthening exercises on OA symptoms, physical function, mood, spiritual health, fear of falling, and quality of life in community-dwelling older adults with knee OA. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:27 +0100Purpose: Lumbar spinal stenosis (LSS) is a painful form of spine arthritis, characterized by neurogenic claudication and mobility limitations. Research suggests that people with LSS would benefit from increased physical activity. Yet, to date we do not have disease specific activity guidelines for LSS, and the nature of free-living physical activity (performance) in LSS remains unknown. LSS care providers could endorse the 2008 United States Physical Activity Guidelines, however, we do not know if this is realistic. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 09:56:02 +0100Authors: Han B, Huang H, Li Z, Gong M, Shi W, Zhu C, Gu Z, Zou Z Abstract The present study was undertaken to evaluate the therapeutic effects of Huzhang-Guizhi herb pair (HG), firstly included in Hu-Zhang Power documented in Taiping Shenghui Fang, on monosodium urate (MSU) crystals-induced gouty arthritis in rats. We found that pretreatment with HG in rats with gouty arthritis could significantly attenuate the ankle joint swelling, and this beneficial antigout effect might be mediated, at least in part, by inhibiting tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) production in synovial fluid as well as nuclear transcription factor-κB p65 (NF-κB p65) protein expression in synovial tissue. Moreover, metabonomic analysis demonstrated that 5 and 6 potential bio...
Sun, 20 Mar 2016 00:00:00 +0100Publication date: Available online 19 March 2016 Source:Joint Bone Spine Author(s): Christian Löffler, Horst Sattler, Lena Peters, Anika Tuleweit, Uta Löffler, Daniel Wadsack, Michael Uppenkamp, Raoul Bergner Objectives Power Doppler ultrasound is used to assess joint vascularity in acute arthritis. PDUS signals have been correlated with synovial histology and bone deterioration. Little is known about the correlation between power Doppler signals and synovial white blood count. In our study, we analyzed power Doppler signals in inflammatory joint diseases including gout, calcium pyrophosphate deposition disease, rheumatoid arthritis, spondyloarthritis and others and correlated power Doppler signals with synovial white blood count and with serologic markers of inflammation. Met...
Sun, 20 Mar 2016 00:00:00 +0100Publication date: 1 July 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 143 Author(s): E. Russo, N. Gaglianone, S. Baldassari, B. Parodi, I. Croce, A.M. Bassi, S. Vernazza, G. Caviglioli This work was based on the study of an intra-articular delivery system constituted by a poloxamer gel vehiculating clodronate in chitosan nanoparticles. This system has been conceived to obtain a specific and controlled release of clodronate in the joints to reduce the arthritis rheumatoid degenerative effect. Clodronate (CLO) is a first-generation bisphosphonate with anti-inflammatory properties, inhibiting the cytokine and NO secretion from macrophages, therefore causing apoptosis in these cells. This is related to its ability to be metabolized by cells and converted into a cytotoxi...
Sun, 20 Mar 2016 00:00:00 +0100Abstract C1q/TNF‐related protein 3 (CTRP3) is a secreted hormone that modulates hepatic glucose and lipid metabolism. Its circulating levels are reduced in human and rodent models of obesity, a metabolic state accompanied by chronic low‐grade inflammation. Recent studies have demonstrated an anti‐inflammatory role for recombinant CTRP3 in attenuating LPS‐induced systemic inflammation, and its deficiency markedly exacerbates inflammation in a mouse model of rheumatoid arthritis. We used genetic mouse models to explore the immunomodulatory function of CTRP3 in response to acute (LPS challenge) and chronic (high‐fat diet) inflammatory stimuli. In a sublethal dose of LPS challenge, neither CTRP3 deficiency nor its overexpression in transgenic mice had an impact on IL‐1β, IL‐6, T...
Sat, 19 Mar 2016 22:54:02 +0100This study demonstrated that XFC is efficacious for RA and explained its potential metabolomics mechanism. PMID: 26989506 [PubMed] (Source: Autoimmune Diseases)
Sat, 19 Mar 2016 10:51:02 +0100CONCLUSIONS: Currently, knee OA treatment does not address the progressively inflammatory environment of the joint. More investigation is needed regarding products of regenerative medicine, but they may ultimately have profound implications in the way knee OA is managed. PMID: 26985986 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Sat, 19 Mar 2016 09:19:16 +0100Conclusion: The improvement of health services is essential for an effective response to the double burden of illness in the middle- and low-income countries. (Source: Revista Brasileira de Epidemiologia)
Sat, 19 Mar 2016 09:19:16 +0100Conclusions: Because these diseases are associated with modifiable risk factors, the prevention with population focus is the best strategy to reduce the burden of these diseases. (Source: Revista Brasileira de Epidemiologia)
Sat, 19 Mar 2016 00:00:00 +0100In conclusion, the ratio of psoriatic arthritis in Japan is increasing, and nearly 10% of new psoriasis patients had psoriatic arthritis. This study shows the current status of psoriatic arthritis in Japan, including several unexpected findings such as male predominance, longer duration between the onset of cutaneous psoriasis and arthritis, and dominance of polyarthritis. (Source: The Journal of Dermatology)
Sat, 19 Mar 2016 00:00:00 +0100This article reviews the clinical and research utility of obtaining PROs across domains applicable to the experience of juvenile idiopathic arthritis and summarizes available self-report and parent-proxy PRO measures. Current challenges and limitations of PRO usage are discussed. (Source: Rheumatic Disease Clinics of North America)
Sat, 19 Mar 2016 00:00:00 +0100To objectively measure physical activity levels in a cohort of juvenile dermatomyositis (JDM) patients; to compare physical capacity and health-related quality of life in JDM patients and their healthy controls (CTRL) matched by physical activity levels; and to associate physical activity variables with disease-related parameters, physical capacity, and health-related quality of life. (Source: Seminars in Arthritis and Rheumatism)
Sat, 19 Mar 2016 00:00:00 +0100Publication date: Available online 19 March 2016 Source:Reumatología Clínica (English Edition) Author(s): Adela Gallego-Flores, Carmen Carrasco-Cubero, Juan José Aznar-Sánchez, Eugenio Chamizo-Carmona (Source: Reumatologia Clinica)
Sat, 19 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: FEBS Letters)
Fri, 18 Mar 2016 23:15:02 +0100Authors: Hashimoto A, Kanisawa Y, Fujimi A, Nakajima C, Hayasaka N, Yamada S, Okuda T, Minami S, Yamauchi N, Iwasaki S, Suzuki A, Kato J Abstract A 61-year-old woman with rheumatoid arthritis who was undergoing hemodialysis for end-stage renal failure was transferred to our hospital due to severe thrombocytopenia and anemia. A bone marrow biopsy showed the complete absence of megakaryocytes and erythroblasts. Cyclosporine treatment resulted in the improvement of her megakaryocyte and erythroblast levels, and a decrease in her serum level of anti-c-Mpl (thrombopoietin receptor) antibodies. After this initial improvement, her anemia progressively worsened, despite the continuous administration of immunosuppressive therapy with cyclosporine. Her platelet and leukocyte counts remained ...
Fri, 18 Mar 2016 20:58:02 +0100Strengthening the muscles around the joints 'unloads' pressure on them, keeping them mobile rather than stiff. Here, from head to toe, are the exercises that can help... (Source: the Mail online | Health)
Fri, 18 Mar 2016 20:16:36 +0100Steven Reinberg, HealthDay News Acetaminophen -- sold as Tylenol -- isn't effective at relieving osteoarthritis pain in the hip or knee, or for improving joint function, a new study finds. (Source: Health News - UPI.com)
Fri, 18 Mar 2016 18:19:30 +0100Abstract: In cases of chronic distal radioulnar joint (DRUJ) instability without DRUJ arthritis, reconstruction of the mechanical integrity of the radioulnar ligaments of the triangular fibrocartilage complex has been considered an ideal surgical treatment. However, reconstructive methods have several disadvantages. We evaluated volar stabilization of the DRUJ for chronic instability using the pronator quadratus (PQ) to determine whether it provided (1) proper stability, (2) restored wrist function, (3) was relatively convenient, and (4) was associated with a low complication rate. Altogether, 21 patients with chronic DRUJ instability (12 men, 9 women) with a mean age of 34 years (range, 17–65 years) were enrolled in the study. The diagnostic criteria were as follows: 3 months after...
Fri, 18 Mar 2016 17:03:22 +0100(Reuters) - Pfizer Inc said on Friday its Xeljanz rheumatoid arthritis drug succeeded in meeting primary and secondary goals of a pair of late stage clinical trials in ulcerative colitis, results that could help pave the way for an additional approval for the oral medicine. (Source: Reuters: Health)
Fri, 18 Mar 2016 16:19:48 +0100(R)-Roscovitine, a pharmacological inhibitor of kinases, is currently in phase II clinical trial as a drug candidate for the treatment of cancers, Cushing's disease and rheumatoid arthritis. We here review the data that support the investigation of (R)-roscovitine as a potential therapeutic agent for the treatment of cystic fibrosis (CF). (R)-Roscovitine displays four independent properties that may favorably combine against CF: (1) it partially protects F508del-CFTR from proteolytic degradation and favors its trafficking to the plasma membrane; (2) by increasing membrane targeting of the TRPC6 ion channel, it rescues acidification in phagolysosomes of CF alveolar macrophages (which show abnormally high pH) and consequently restores their bactericidal activity; (3) its effects on neutrophi...
Fri, 18 Mar 2016 14:40:00 +0100Acetaminophen, known best as the brand Tylenol, is often the first pain-reliever osteoarthritis patients try. But a new study concludes that the drug has no effect on osteoarthritis pain in the knee or hip, no matter how large the dose. (Source: Forbes.com Healthcare News)
Fri, 18 Mar 2016 14:27:21 +0100Prescription diclofenac a more effective choice for short-term pain relief, researchers say Source: HealthDay Related MedlinePlus Pages: Osteoarthritis, Pain, Pain Relievers (Source: MedlinePlus Health News)
Fri, 18 Mar 2016 12:00:00 +0100Conclusion This Swiss study reviewed drugs commonly used and recommended to help pain associated with osteoarthritis. Through indirect comparison, it identified those likely to be most effective (diclofenac 150 mg/day) and those that are pretty likely to be useless (paracetamol any dose). The study looked at a large number of good-sized RCTs – all with more than 100 people – and covered a useful range of NSAIDS. The quality of the RCTs was also assessed and was generally not highly biased, although variable. However, the review included many indirect comparisons of the drugs, which is less accurate and reliable than direct comparisons. But without more direct comparisons available, this is probably the best we have to go on for now. The main implication from the study authors' point of...
Fri, 18 Mar 2016 09:00:00 +0100Many Danes are prescribed NSAIDs for the treatment of painful conditions, fever and inflammation. But the treatment also comes with side effects, including the risk of ulcers and increased blood pressure. A major new study now gathers all research in the area. This shows that arthritis medicine is particularly dangerous for heart patients, and also that older types of arthritis medicine, (Source: World Pharma News)
Fri, 18 Mar 2016 07:00:00 +0100Though considered a primary treatment for osteoarthritis, acetaminophen is not effective for improving pain and physical function in patients with the disease, say researchers. (Source: Health News from Medical News Today)
Fri, 18 Mar 2016 07:00:00 +0100Title: Acetaminophen Won't Help Arthritis Pain, Study FindsCategory: Health NewsCreated: 3/17/2016 12:00:00 AMLast Editorial Review: 3/18/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Fri, 18 Mar 2016 04:13:34 +0100Paracetamol has long been the main treatment for osteoarthritis, the leading cause of pain in the elderly, but it is actually ineffective and carries side effects, a University of Bern study found. (Source: the Mail online | Health)
Fri, 18 Mar 2016 04:00:00 +0100(Institute for Quality and Efficiency in Health Care) Drug manufacturer presented no relevant data and claimed no added benefit. Notable was the non-publication of literature searches and analyses. (Source: EurekAlert! - Medicine and Health)
Fri, 18 Mar 2016 00:17:00 +0100Prescription diclofenac a more effective choice for short-term pain relief, researchers say (Source: WebMD Health)
Fri, 18 Mar 2016 00:03:01 +0100Authors: Afifi TO, MacMillan HL, Boyle M, Cheung K, Taillieu T, Turner S, Sareen J Abstract BACKGROUND: A large literature exists on the association between child abuse and mental health, but less is known about associations with physical health. The study objective was to determine if several types of child abuse were related to an increased likelihood of negative physical health outcomes in a nationally representative sample of Canadian adults. DATA AND METHODS: Data are from the 2012 Canadian Community Health Survey-Mental Health (n = 23,395). The study sample was representative of the Canadian population aged 18 or older. Child physical abuse, sexual abuse, and exposure to intimate partner violence were assessed in relation to self-perceived general health and 13 self-repor...
Fri, 18 Mar 2016 00:01:00 +0100PARACETAMOL offers no relief from the agony of arthritis, research suggests. (Source: Daily Express - Health)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion In our cohort, anti-PAD3 antibodies correlate with joint erosion score. Therefore, anti-PAD3 antibodies might represent promising markers to predict joint damage in RA patients. (Source: Autoimmunity Reviews)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions Presence of a contact lens after Boston keratoprosthesis implantation decreases the risk of postoperative complications; this has been clinically experienced by ophthalmologists, but never before has the benefit of contact lens use in this patient population been statistically documented. (Source: British Journal of Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100Publication date: Available online 17 March 2016 Source:Joint Bone Spine Author(s): Dieu-Donné Ouédraogo, Joelle Tiendrébéogo, Patrice Laurent Wendpouiré Guiguimdé, Pascal Ismaël Nikiéma, Dieudonné Ouédraogo, Fulgence Kaboré, Enselme Zongo, Gilles Hayem (Source: Joint Bone Spine)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions: IgG4‐RD is a multisystem disorder that commonly affects older men, with a propensity for relapse, recurrence, and malignancy. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: Arhalofenate, at 800 mg, significantly decreased gout flares when compared to allopurinol 300 mg. Arhalofenate was well tolerated and appeared safe. Arhalofenate is the first Urate‐Lowering Anti‐Flare Therapy. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: We describe the first case of gonosomal TNFRSF1A mosaicism in TRAPS due to a novel, somatic 24 nucleotide in‐frame deletion. The clinical picture including complete response to IL‐1 blockade were typical for TRAPS. This case adds TRAPS to the list of dominantly inherited autoinflammatory diseases reported to be caused by somatic (or postzygotic) mutation. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: An increase in cumulative corticosteroid dose over 1 year was observed for both treatments, but was significantly smaller for the belimumab group compared with placebo. More patients who received belimumab decreased oral corticosteroids, and fewer increased, compared with placebo. These data suggest that belimumab may be steroid sparing. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions and Perspectives HLA‐B27/β2m expression in this rat model renders the host hyper‐responsive to microbial antigens from infancy. Early activation of innate immunity and expansion of a mucosal Th17 signature are soon followed by dysbiosis in HLA‐B27/β2m+ve animals. Perturbed mucosal immunity and dysbiosis strongly merit further study in both pre‐diseased and diseased SpA patient populations. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: Structural brain abnormalities were observed in 55.2% and associated with NP manifestations, aCL antibodies and corticosteroid use. Longitudinal studies have to follow these patients closely to determine permanent neurological damage. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions: Our results support a protective role of IgE in SLE pathogenesis through the modulation of inflammatory response by pDCs. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100(Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: Our findings validate relevant human biomarkers of tissue injury identified in a mouse model. Analysis of SF rather than blood more accurately reflects this response. The response is associated with patient‐relevant outcomes over this early period, SF IL‐6 acting as a single representative marker. Longitudinal outcomes will determine if these molecules are biomarkers of subsequent disease risk. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100(Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion. HDL's net CEC did not change significantly after 6 months of new RA therapy, except in those with impaired baseline CEC receiving TOC. Change in disease activity was associated with change in net CEC. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: In LN, the expected improvement and deterioration in renal outcomes can be estimated by multistate modelling and is predicated by identifiable risk factors. New therapeutic interventions for LN should meet or exceed these expectations. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: Overall these data demonstrate the potential use of gallein or novel inhibitors of G protein βγ signaling in SLE treatment. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)