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Preview: MedWorm: High Intensity Focused Ultrasound Therapy

MedWorm: High Intensity Focused Ultrasound Therapy



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the High Intensity Focused Ultrasound Therapy category.



Last Build Date: Tue, 29 Mar 2016 16:21:55 +0100

 



V5-06 initial experience during development of laparoscopic 12mm hifu probe

Mon, 28 Mar 2016 19:24:10 +0100

We present our initial experience with this emerging technology. (Source: The Journal of Urology)

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Mp34-16 evaluation of a laparoscopic high intensity focused ultrasound probe for the ablation of small renal masses

Mon, 28 Mar 2016 19:24:05 +0100

Sonatherm 600i (Sonatherm) has FDA 510(k) clearance in the United States for performing laparoscopic or intraoperative ablation of soft tissue from the ultrasound focal zone back to the surface of the targeted ablation area. We perform a Pilot phase 1 clinical study to assess the safety and efficacy of a 12mm high intensity focused ultrasound (HIFU) probe for the treatment of small enhancing renal masses. (Source: The Journal of Urology)



Mp18-19 local radical tumor ablation through combined transurethral resection and transrectal high intensity focused ultrasound: a valid therapy to treat high risk prostate cancer ?

Mon, 28 Mar 2016 19:24:01 +0100

Monocentric prospective long term cohort evaluation regarding therapeutic efficacy and side effects of combined “TURP+HIFU” for local radical ablation of high risk Prostate Cancer (hrPCa). (Source: The Journal of Urology)



Mp18-17 comparisons of oncological and functional outcomes among radical retropubic prostatectomy, high dose rate brachytherapy, cryoablation and high-intensity focused ultrasound for localized prostate cancer: a prospective, controlled, nonrandomized trial

Mon, 28 Mar 2016 19:24:01 +0100

To conduct a prospective, controlled, nonrandomized, single institutional comparison for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. (Source: The Journal of Urology)



Mp18-15 efficacy of high intensity focused ultrasound (hifu) as a primary monotherapy for low risk localized prostate cancer: outcomes from the enlight trial

Mon, 28 Mar 2016 19:24:01 +0100

Introduction and Objective: Between 2007 and 2010 transrectal ultrasound guided high intensity focused ultrasound (HIFU) was employed in a FDA approved IDE registration clinical trial (ENLIGHT Trial) in men with low grade, low risk prostate cancer. Efficacy outcomes are reported. (Source: The Journal of Urology)



Mp18-13 primary focal cryotherapy in the treatment of predominantly anterior and high volume intermediate and high-risk localized prostate cancer in the uk

Mon, 28 Mar 2016 19:24:01 +0100

Focal cryotherapy may offer good oncological outcomes with minimal side-effects. We recently commenced a focal cryotherapy program, primarily for anterior or transition zone lesions, to complement our focal HIFU programme. We assessed safety, adverse-events, functional outcomes and disease control. (Source: The Journal of Urology)

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Mp18-08 focal hifu for treatment of localised prostate cancer: a multi-centre registry experience

Mon, 28 Mar 2016 19:24:01 +0100

We report on the medium term oncological and functional outcomes of those treated wth focal HIFU. (Source: The Journal of Urology)



Mp18-06 salvage external beam radiation therapy (ebrt) for local recurrence after high intensity focused ultrasound (hifu) failure versus salvage hifu for local recurrence after ebrt failure: a matched pair comparison

Mon, 28 Mar 2016 19:24:01 +0100

EBRT is one of the gold standard treatments for localized prostate cancer. High Intensity Focused Ultrasound (HIFU) is a new minimally invasive treatment option with promising outcomes. HIFU is one of salvage option after EBRT failure and EBRT is the standard salvage option for local relapse after HIFU. No randomized study is available to compare these two strategies of salvage treatment after a first line therapy. The goal was to evaluate the oncologic outcomes by using a matched pair analysis to compare patients treated with HIFU first + salvage EBRT (S-EBRT) versus EBRT first + salvage HIFU (S-HIFU) (Source: The Journal of Urology)



Mp18-02 development and internal validation of a multivariable prediction model for biochemical failure after focal salvage high intensity focused ultrasound for locally recurrent prostate cancer: presentation of a risk score for individual patient prognosis.

Mon, 28 Mar 2016 19:24:01 +0100

This study therefore aims to develop and internally validate a prediction model for biochemical failure (BF) following focal salvage high intensity focused ultrasound (HIFU). (Source: The Journal of Urology)



Mp18-01 whole gland salvage high intensity focused ultrasound of prostate: intermediate term results of prospective phase ii clinical trial

Mon, 28 Mar 2016 19:24:01 +0100

Salvage high intensity focused ultrasound (s-HIFU) is a potentially curative minimally invasive treatment for radio-recurrent prostate cancer (rr-PCa). Aim of this phase II trial was to prospectively assess oncologic and functional outcomes along with the morbidity of s-HIFU. (Source: The Journal of Urology)



Pd06-10 multi-parametric magnetic resonance imaging to evaluate and monitor prostate cancer after high-intensity focused ultrasound: implication for targeted focal therapy

Mon, 28 Mar 2016 19:24:01 +0100

We evaluated the usefulness of multi-parametric magnetic resonance imaging (mpMRI) in monitoring recurrence of prostate cancer after high-intensity focused ultrasound (HIFU). (Source: The Journal of Urology)

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Pi-lba04 hemiablation hifu for unilateral localized prostate cancer: a prospective multicenter trial

Mon, 28 Mar 2016 19:23:59 +0100

Focal therapy has emerged as an attractive intermediate option between active surveillance (AS) and radical treatments. Technological improvements of ablative technologies and diagnostic tools including multiparametric MRI (mpMRI) and guided biopsy (Bx) enable precise targeting and treatment of the tumors. The purpose of this study is to evaluate the efficacy and safety of high intensity focused ultrasound (HIFU) hemiablation for unilateral localized prostate cancer (PCa). (Source: The Journal of Urology)



Transarterial chemoembolization combination therapy vs monotherapy in unresectable hepatocellular carcinoma: a meta-analysis.

Thu, 24 Mar 2016 12:07:02 +0100

CONCLUSIONS: Transcatheter arterial chemoembolization in combination with percutaneous ablation therapies may improve the survival of patients with unresectable HCC. PMID: 27002950 [PubMed - as supplied by publisher] (Source: Tumori)



HIFU for Prostate Cancer

Wed, 23 Mar 2016 03:43:10 +0100

MIAMI. (Ivanhoe Newswire) -- A treatment that can remove prostate cancer while still preserving a man’s quality of life. It’s now available in the United States for the first time ever. It’s called high-intensity focused ultrasound, or HIFU. (Source: Medical Headlines From Ivanhoe.com)



Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) hyperthermia for recurrent rectal cancer: MR thermometry evaluation and preclinical validation

Tue, 22 Mar 2016 23:00:00 +0100

This study demonstrates the feasibility of delivering hyperthermia to pelvic targets using MR-HIFU. Sonications in normal pig muscle validated hyperthermia delivery in locations representing rectal recurrences using a clinical MR-HIFU system. Prospective imaging in volunteers with rectal cancer identified criteria for patient selection and preparation to achieve adequate targeting depth and MR thermometry stability. These results enable human trials of MR-HIFU hyperthermia. (Source: International Journal of Radiation Oncology * Biology * Physics)



Modern Palliative Treatments for Metastatic Bone Disease: Awareness of Advantages, Disadvantages, and Guidance

Sun, 20 Mar 2016 06:07:24 +0100

This article aims to present these palliative treatments for the patients with bone metastases, summarize the clinical applications, and review the techniques and results. Methods: It gives an extensive overview of the possibilities of palliation in patients with metastatic cancer to the bone. Results and Discussion: Currently, modern treatments are available for the palliative management of patients with metastatic bone disease. These include modern radiation therapy, chemotherapy, embolization, electrochemotherapy, radiofrequency ablation, and high-intensity focused ultrasound. As such it is of interest for all physicians with no experience with these developments to make palliative procedures safer and more reliable. (Source: The Clinical Journal of Pain)

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Preparation of HIFU-triggered tumor-targeted hyaluronic acid micelles for controlled drug release and enhanced cellular uptake

Sun, 20 Mar 2016 00:00:00 +0100

In this study, a novel type of high intensity focused ultrasound (HIFU)-triggered active tumor-targeting polymeric micelle was prepared and investigated for controlled drug release and enhanced cellular uptake. Amphiphilic hyaluronic acid (HA) conjugates were synthesized to form docetaxel loaded micelles in aqueous conditions with high encapsulation efficiencies of over 80%. The micelle sizes were limited to less than 150nm, and they varied slightly according to the encapsulated drug amount. Modifying the micellar surface modification with polyethylene glycol diamine successfully inhibited premature drug leakage at a certain level, and it can be expected to prolong the circulation time of the particles in blood. In addition, high-intensity focused ultrasound was introduced to control the r...



DCE-MRI and IVIM-MRI of rabbit Vx2 tumors treated with MR-HIFU-induced mild hyperthermia

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions Changes in DCE and IVIM parameters were detected after hyperthermia and were variable between the rabbits. DCE- and IVIM-MRI may be promising tools to assess tumor responses to hyperthermia. Further research in a larger number of subjects is necessary in order to assess their value for treatment response monitoring. (Source: Journal of Therapeutic Ultrasound)



Unilateral HIFU: More Cons Than Pros(tate)?Unilateral HIFU: More Cons Than Pros(tate)?

Fri, 11 Mar 2016 15:44:46 +0100

A small study of high-intensity focused ultrasound in localized prostate cancer fails to make the case for this treatment option, says Dr Gerald Chodak. Medscape Urology (Source: Medscape Hematology-Oncology Headlines)



Preparation of HIFU-triggered tumor-targeted hyaluronic acid micelles for controlled drug release and enhanced cellular uptake.

Tue, 08 Mar 2016 23:00:00 +0100

In this study, a novel type of high intensity focused ultrasound (HIFU)-triggered active tumor-targeting polymeric micelle was prepared and investigated for controlled drug release and enhanced cellular uptake. Amphiphilic hyaluronic acid (HA) conjugates were synthesized to form docetaxel loaded micelles in aqueous conditions with high encapsulation efficiencies of over 80%. The micelle sizes were limited to less than 150nm, and they varied slightly according to the encapsulated drug amount. Modifying the micellar surface modification with polyethylene glycol diamine successfully inhibited premature drug leakage at a certain level, and it can be expected to prolong the circulation time of the particles in blood. In addition, high-intensity focused ultrasound was introduced to control the r...



One-lung flooding reduces the ipsilateral diaphragm motion during mechanical ventilation

Tue, 08 Mar 2016 00:00:00 +0100

Conclusion OLF leads to a drastic reduction of diaphragm motion on the ipsilateral side which implies that targeting and motion compensation algorithms for interventions like high-intensity focused ultrasound ablation of intrapulmonary and hepatic lesions might not be required. (Source: European Journal of Medical Research)

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Class-DE Ultrasound Transducer Driver for HIFU Therapy

Fri, 04 Mar 2016 16:07:08 +0100

This paper presents a practical implementation of an integrated MRI-compatible CMOS amplifier capable of directly driving a piezoelectric ultrasound transducer suitable for high-intensity focused ultrasound (HIFU) therapy. The amplifier operates in Class DE mode without the need for an output matching network. The integrated amplifier has been implemented with the AMS AG H35 CMOS process. A class DE amplifier design methodology for driving unmatched piezoelectric loads is presented along with simulation and experimental results. The proposed design achieves approximately 90% efficiency with over 800 mW of output power at 1010 kHz. The total die area including pads is $2 ~{rm mm}^{2}$ . Compatibility with MRI was validated with B1 imaging of a phantom and the amplifier circuit. (Source: IEE...



HIFU in Prostate Cancer: Are Patients 'Guinea Pigs'?HIFU in Prostate Cancer: Are Patients 'Guinea Pigs'?

Thu, 03 Mar 2016 15:32:13 +0100

The FDA rejected high-intensity ultrasound (HIFU) for treating prostate cancer and then approved a device as safe for 'prostate ablation.' Is that a mixed message? Medscape Urology (Source: Medscape Radiology Headlines)



High intensity focused ultrasound induced in vivo large volume hyperthermia under 3D MRI temperature control.

Tue, 01 Mar 2016 00:00:00 +0100

CONCLUSIONS: The capability of MR-HIFU to induce accurate, spatially uniform, and robust mild hyperthermia in large deep-seated volumes was successfully demonstrated through a series of in vivo animal experiments. PMID: 26936737 [PubMed - in process] (Source: Medical Physics)



A simple method for determining the coagulation threshold temperature of transparent tissue-mimicking thermal therapy gel phantoms: Validated by magnetic resonance imaging thermometry.

Tue, 01 Mar 2016 00:00:00 +0100

CONCLUSIONS: The opacity quantification method provides a fast and reproducible estimate of the coagulation threshold temperature of transparent temperature-sensitive gel phantoms. The temperatures determined using this method were well within the range of temperatures estimated using MR-thermometry. Due to the specific heating capabilities of the PCR machine, and the robust determination of coagulation threshold temperatures based on the statistically significant increase in the opacity of gel samples, coagulation temperatures can be determined more precisely and with less variability compared to MRI-based methods. PMID: 26936702 [PubMed - in process] (Source: Medical Physics)



The combination therapy of high-intensity focused ultrasound with radiotherapy in locally advanced pancreatic carcinoma

Mon, 29 Feb 2016 00:00:00 +0100

The aim of the present study is to evaluate the effectiveness of the combined application of high-intensity focused ultrasound (HIFU) and radiotherapy in the treatment of locally advanced pancreatic carcinoma ... (Source: World Journal of Surgical Oncology)

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A Comparative Study of Surgical Splenectomy, Partial Splenic Embolization, and High-Intensity Focused Ultrasound for Hypersplenism

Fri, 26 Feb 2016 00:00:00 +0100

Conclusions— High-intensity focused ultrasound has wide clinical indications for hypersplenism and may be safer than other treatment methods. Therefore, it is a good alternative procedure for patients with a high surgical risk. (Source: Journal of Ultrasound in Medicine)



Targeted prostate biopsy and MR-guided therapy for prostate cancer

Wed, 24 Feb 2016 00:00:00 +0100

Abstract Prostate cancer is the most commonly diagnosed noncutaneous cancer and second-leading cause of death in men. Many patients with clinically organ-confined prostate cancer undergo definitive treatment of the whole gland including radical prostatectomy, radiation therapy, and cryosurgery. Active surveillance is a growing alternative option for patients with documented low-volume, low-grade prostate cancer. With recent advances in software and hardware of MRI, multiparametric MRI of the prostate has been shown to improve the accuracy in detecting and characterizing clinically significant prostate cancer. Targeted biopsy is increasingly utilized to improve the yield of MR-detected, clinically significant prostate cancer and to decrease in detection of indolent prostate cancer....



Targeted antibiotic delivery using low temperature-sensitive liposomes and magnetic resonance-guided high-intensity focused ultrasound hyperthermia.

Sun, 21 Feb 2016 06:25:02 +0100

The objectives of this study were to 1) develop low temperature-sensitive liposomes (LTSLs) containing an antimicrobial agent (ciprofloxacin) for induced release at mild hyperthermia (∼42 °C), 2) characterise in vitro ciprofloxacin release, and efficacy against Staphylococcus aureus plankton and biofilms, and 3) determine the feasibility of localised ciprofloxacin delivery in combination with MR-HIFU hyperthermia in a rat model. LTSLs were loaded actively with ciprofloxacin and their efficacy was determined using a disc diffusion method, MBEC biofilm device, and scanning electron microscopy (SEM). Ciprofloxacin release from LTSLs was assessed in a physiological buffer by fluorescence spectroscopy, and in vivo in a rat model using MR-HIFU. Results indicated that < 5% ciprofloxacin w...



Dynamic contrast-enhanced MRI serves as a predictor of HIFU treatment outcome for uterine fibroids with hyperintensity in T2-weighted images.

Sat, 20 Feb 2016 10:15:03 +0100

Authors: Zhao WP, Chen JY, Chen WZ Abstract The aim of the present study was to investigate the efficacy of dynamic contrast-enhanced magnetic resonance imaging (MRI) in predicting the outcome of using ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for the treatment of uterine fibroids with T2 hyperintensity under MRI. A total of 131 uterine fibroids from 131 patients that appeared hyperintense under T2-weighted MRI were analyzed. The uterine fibroids were subjectively categorized into slight, irregular or regular enhancement groups, according to pretreatment dynamic contrast-enhanced MRI in the arterial phase within 60 sec after the injection of gadolinium. The non-perfused volume (NPV), which is indicative of successful ablation, was represented as the non...



Three-dimensional multimodal image non-rigid registration and fusion in a High Intensity Focused Ultrasound system.

Fri, 19 Feb 2016 15:56:06 +0100

Authors: Lu X, Suo S, Liu H, Zhang S Abstract High Intensity Focused Ultrasound (HIFU) has been successfully applied in tumor therapy. For a successful HIFU therapy, it is crucial to localize the tumor region accurately. In this paper, we present a semi-automatic non-rigid registration method for implementing image guided surgery navigation and localization by matching pre-operative CT/MR images and intra-operative ultrasound images. The global motion of the target is modeled by an affine transformation, while the local deformation of the target is described by Free-Form Deformation (FFD) based on B-splines. The results of our experiments on simulated and real data show that the non-rigid registration method based on HPV interpolation (partial volume based on the Hanning windowed s...

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Design of a low power hybrid HIFU applicator for haemostasis based on acoustic propagation modelling.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: Temperatures reached at focus suggest that this applicator has good efficiency, which notably reduces the power typically needed for haemostasis effect. PMID: 26708742 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)



Specific antitumour immunity of HIFU-activated cytotoxic T lymphocytes after adoptive transfusion in tumour-bearing mice.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: HIFU could enhance CTL's specific antitumour immunity. Adoptive transfer of HIFU-activated T lymphocytes could increase local antitumour immunity, and elicit stronger inhibition on tumour growth and progression, with more survival benefit in the autologous tumour-bearing mice. PMID: 26708472 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)



A comparison of high-intensity focused ultrasound and uterine artery embolisation for the management of caesarean scar pregnancy.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: Based on our results, it appears that either HIFU or UAE combined with suction curettage under hysteroscopic guidance is safe and effective in treating patients with CSP. Compared with UAE, HIFU treatment for CSP has the advantages of a lower pain score and fewer adverse effects. PMID: 26644262 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)



Localised hyperthermia in rodent models using an MRI-compatible high-intensity focused ultrasound system.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: The MRI-compatible HIFU system was successfully adapted to perform localised mild hyperthermia treatment in rodent models. A target temperature of 42 °C was well-maintained in a rat thigh model for 30 min. PMID: 26540488 [PubMed - in process] (Source: International Journal of Hyperthermia)



Magnetic resonance-guided high-intensity focused ultrasound for uterine fibroids: Mid-term outcomes of 36 patients treated with the Sonalleve system.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: Treatment of uterine fibroids by MRgFUS is efficient and results in low morbidity and satisfactory clinical efficacy with a mean follow-up of 21.4 months. PMID: 26367772 [PubMed - in process] (Source: International Journal of Hyperthermia)

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Ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for the treatment of patients with adenomyosis and prior abdominal surgical scars: A retrospective study.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSION: The prior abdominal surgical scars have no significant influence on the effectiveness of HIFU treatment for adenomyosis. The risk of skin burn is higher in patients with abdominal scars than without, but the incidence rate is still acceptable. PMID: 26367457 [PubMed - in process] (Source: International Journal of Hyperthermia)



High intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva: Factors affecting effectiveness and recurrence.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: HIFU is safe and effective in treating NNEDV. Its effectiveness is correlated with age, size of lesion and pathological type, whereas post-treatment recurrence rates may be related to the duration of the disease and the pathological sub-types. PMID: 26367074 [PubMed - in process] (Source: International Journal of Hyperthermia)



Synthesis and characterisation of ultrasound imageable heat-sensitive liposomes for HIFU therapy.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSION: A stable US-imageable liposome co-loaded with Dox and PFP for in vivo IGDD was developed. Data suggest that HIFU can induce cellular uptake and toxicity with E-LTSLs. PMID: 26185910 [PubMed - in process] (Source: International Journal of Hyperthermia)



High intensity focused ultrasound ablation for submucosal fibroids: A comparison between type I and type II.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSION: Based on our results with a small number of subjects, HIFU is suitable for both type I and type II submucosal fibroids. It seems that type II submucosal fibroids are more sensitive to HIFU ablation. Future studies with larger sample sizes and longer follow-up times to investigate the long-term results, including long-term symptom relief, pregnancy outcomes, and the recurrence rate as well as the reintervention rate are needed. PMID: 26044873 [PubMed - in process] (Source: International Journal of Hyperthermia)



A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment.

Thu, 18 Feb 2016 06:10:02 +0100

Authors: Chao YT, Hsu CJ, Yu YL, Yen JY, Ho MC, Chen YY, Chang HC, Lian FL Abstract The main challenge in transcostal high-intensity focused ultrasound therapy is minimising heat deposition in the ribs while ensuring that a sufficient dose is delivered to the target region. Current approaches rely on expensive multichannel phased-array systems to turn the individual transducer on and off according to either geometrical arrangements or complicated wave calculations. To protect the ribs from heating, the ultrasound energy must not only not reach the ribs, but must also not accumulate in front of the ribs. The research in this paper proposes a different approach, of attaching a sound-blocking structure in front of the rib cage with similar effects to those of an engine exhaust muffler...

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Anatomical-based model for simulation of HIFU-induced lesions in atherosclerotic plaques.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSION: The results suggest that a realistic, image-based acoustic and thermal model of the treatment region is capable of predicting the extent of thermal damage to target plaque tissue. The model considered the effect of the wall thickness of large arteries and the heat-sink effect of flowing blood. The model is used for predicting the size and pattern of HIFU damage in vivo. PMID: 25875223 [PubMed - in process] (Source: International Journal of Hyperthermia)



Thermal ablative treatment of uterine fibroids.

Thu, 18 Feb 2016 06:10:02 +0100

Authors: Quinn SD, Gedroyc WM Abstract In addition to surgical methods of treating uterine fibroids, numerous non-invasive treatments have been developed. Many of these involve the use of hyperthermia, the heating of tissue by a variety of methods. These include the use of lasers, radiofrequency, microwave energy and high intensity focused ultrasound, guided by both ultrasound and magnetic resonance imaging. In this review we examine the technology behind these treatment modalities and review the current evidence for their use. PMID: 25815582 [PubMed - in process] (Source: International Journal of Hyperthermia)



Ultrasound guided high intensity focused ultrasound (USgHIFU) ablation for uterine fibroids: Do we need the microbubbles?

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSIONS: CEUS was safe and effective in enhancing US guidance during HIFU ablation of uterine fibroids. Moreover, the use of CEUS during HIFU sonication increased the ablation efficacy, leading to a more relevant fibroid volume reduction at 1 and 3 months. This gap disappeared after 6 months, when there were no differences between the two groups of patients at MRI. However, in our experience, USgHIFU represented a very effective method for the treatment of uterine fibroids, and the use of CEUS during HIFU procedure reduced the treatment time and treatment repetitions for incomplete fibroid ablation. PMID: 25758436 [PubMed - in process] (Source: International Journal of Hyperthermia)



High-intensity focused ultrasound for the treatment of prostate cancer: A prospective trial with long-term follow-up.

Thu, 18 Feb 2016 05:22:02 +0100

CONCLUSIONS: A long-term favourable outcome of HIFU is associated with careful patient selection, with low- to intermediate-risk disease being the ideal case. A low postoperative PSA nadir is a predictor of long-term bNED. PMID: 25485722 [PubMed - in process] (Source: Scandinavian Journal of Urology)



Efficacy of extracorporeal ultrasound-guided high intensity focused ultrasound: An evaluation based on controlled trials in China.

Thu, 18 Feb 2016 01:49:02 +0100

CONCLUSIONS: HIFU should be curtailed in resectable cases and be an alternative in inoperable cases; a combination regimen should not be recommended. The Response Evaluation Criteria in Solid Tumors can be applied to HIFU. PMID: 25758333 [PubMed - indexed for MEDLINE] (Source: International Journal of Radiation Biology)

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Abstract P4-11-11: Patient preferences for minimally invasive and conventional locoregional treatment for early-stage breast cancer; A utility assessment

Thu, 18 Feb 2016 00:00:00 +0100

ConclusionWe are performing a utility analysis of new and existing breast cancer treatments in breast cancer patients and healthy volunteers. This study will yield important information to guide the development and innovation of breast cancer therapies in the future.Citation Format: Knuttel FM, van den Bosch MMAAJ, Young Afat DA, Emaus MJ, van den Bongard DHJG, Witkamp AJ, Verkooijen HM. Patient preferences for minimally invasive and conventional locoregional treatment for early-stage breast cancer; A utility assessment. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-11-11. (Source: Cancer Research)



ERP Therapy, Where Are You?

Mon, 15 Feb 2016 18:45:04 +0100

I recently received an email from a woman in her thirties who has had obsessive-compulsive disorder since she was a child. She came across one of my articles and was interested in learning more about exposure and response prevention (ERP) therapy, as she had never heard of it. She had been to all kinds of health care providers over the years, yet she had never heard of ERP. Unfortunately, emails such as hers are not uncommon, but they sure are frustrating. She’s had OCD for twenty plus years and never heard of ERP? This realization jolts me out of my little corner of the world (or blogosphere) where everyone knows about ERP therapy because we talk about it over and over again. Is progress actually being made? Are we really getting the word out? Sometimes I just don’t think so. It’s b...



Toroidal Transducer for Intraoperative Thermal Ablation of Pancreatic Tumours by High-Intensity Focused Ultrasound. First In Vitro Experiments

Sun, 14 Feb 2016 00:00:00 +0100

Publication date: Available online 12 February 2016 Source:IRBM Author(s): J. Vincenot, A. Kocot, A. Vignot, F. Chavrier, E. Blanc, A. Dupré, M. Rivoire, J.Y. Chapelon, D. Melodelima High-intensity focused ultrasound (HIFU) is produced by ultrasonic transducers usually hemispherical in shape creating elementary lesions with an elliptical volume. These lesions must be placed side by side precisely in order to treat a tumour with safety margins. Recently it has been demonstrated that HIFU transducers with toroidal geometry provide a significant increase in the ablation rate (10.5 cc min−1 for a toroidal transducer vs 0.34 cc min−1 for spherical transducers). The aim of this study is to use this toroidal geometry with electronic beam steering for a possible application to ...



Histopathology of breast cancer after magnetic resonance‐guided high‐intensity focused ultrasound and radiofrequency ablation

Sun, 14 Feb 2016 00:00:00 +0100

ConclusionHistopathological differences between MR‐HIFU‐ablated tissue and RF‐ablated tissue were demonstrated. CK‐8 was more reliable for cell viability assessment than H&E when used directly after ablation, while H&E was more reliable in ablated tissue left in situ for a few days. Our results contribute to improved understanding of histopathological features in breast cancer lesions treated with minimally invasive ablative techniques. (Source: Histopathology)



Modelling the temperature evolution of bone under high intensity focused ultrasound.

Mon, 08 Feb 2016 00:00:00 +0100

Authors: Ten Eikelder HM, Bošnački D, Elevelt A, Donato K, Di Tullio A, Breuer BJ, van Wijk JH, van Dijk EV, Modena D, Yeo SY, Grüll H Abstract Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) has been clinically shown to be effective for palliative pain management in patients suffering from skeletal metastasis. The underlying mechanism is supposed to be periosteal denervation caused by ablative temperatures reached through ultrasound heating of the cortex. The challenge is exact temperature control during sonication as MR-based thermometry approaches for bone tissue are currently not available. Thus, in contrast to the MR-HIFU ablation of soft tissue, a thermometry feedback to the HIFU is lacking, and the treatment of bone metastasis is entirely based on te...

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First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation

Sat, 06 Feb 2016 00:00:00 +0100

Conclusions Our results show that MR-HIFU ablation with the dedicated breast system is safe and results in histopathologically proven tumour necrosis. Key Points • MR-HIFU ablation with the dedicated breast system is safe and feasible • In none of the patients was skin redness or burns observed • No correlation was found between the applied energy and the temperature increase • The correlation between applied energy and size of tumour necrosis was good (Source: European Radiology)



Selective focusing through target identification and experimental acoustic signature extraction: Numerical experiments.

Sat, 06 Feb 2016 00:00:00 +0100

Authors: Rodriguez S, Jacob X, Gibiat V Abstract Using transducer arrays and appropriate emission delays allow to focus acoustic waves at a chosen location in a medium. The focusing spatial accuracy depends on the accurate knowledge of its acoustic properties. When those properties are unknown, methods based on the Time-Reversal principle allow accurate focusing. Still, these methods are either intrusive (an active source has to be introduced at the target location first), either blind (the target cannot be selected in the presence of several objects.) The purpose of the present work is to achieve non-invasive accurate focusing on a selected target using inaccurate acoustic properties for the investigated medium. Potential applications are for instance noninvasive surgery based on ...



The Influence of Oxytocin on the Blood Perfusion of Uterine Fibroids: Contrast-enhanced Ultrasonography Evaluation

Wed, 03 Feb 2016 00:00:00 +0100

Conclusion This CEUS study demonstrated that the use of parenteral oxytocin can significantly reduce the blood perfusion of the uterine fibroids, which may help to enhance the therapeutic efficacy for high intensity focused ultrasound ablation of uterine fibroids. (Source: Journal of Medical Ultrasound)



Renal sympathetic denervation using MR-guided high-intensity focused ultrasound in a porcine model

Wed, 03 Feb 2016 00:00:00 +0100

Conclusions Performing renal denervation non-invasively with MRgHIFU was shown to be both safe and effective as determined by norepinephrine levels in a porcine model. This approach may be a promising alternative to catheter-based strategies. (Source: Journal of Therapeutic Ultrasound)



Development of a computational tool for HIFU ablation therapy to assure safety of the patient

Mon, 01 Feb 2016 00:00:00 +0100

Introduction: High Intensity Focused Ultrasound (HIFU) is being investigated for routine clinical practice with the aim of enabling thermal ablation of tumors, also associated to others therapies, e.g. radiation therapy. HIFU treatment is based on the power of a focused ultrasound beam to locally heat biological tissues over a necrotic level with minimal impact on the surrounding tissues. The clinical practice requires a standardization of quality assurance protocols and the development of computational tools to evaluate the output of clinical HIFU devices and to ensure safe delivery of HIFU treatment. (Source: Physica Medica: European Journal of Medical Physics)

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A new refined acoustic and thermal coupling model for temperature rise in MR-guided HIFU

Mon, 01 Feb 2016 00:00:00 +0100

Introduction: The success of MRgFUS therapy relies on the accuracy of thermal mapping of sonication, which is obtained with guided MR. Unfortunately, inhomogeneities in the medium of propagation can cause significant distortion of the ultrasound beam, resulting in changes in focal-zone amplitude, location and shape. An adequate description of absorption, diffraction and nonlinear phenomena can be necessary to attenuate the limits of the technique. The aim of this study is to evaluate a quantitative comparison between MRgFUS experimentally measured thermal fields and that obtained using finite element method with Monte Carlo (MC). (Source: Physica Medica: European Journal of Medical Physics)



HIFU generated fast hyperthermia as a new option for glioblastoma treatment

Mon, 01 Feb 2016 00:00:00 +0100

Introduction: Glioblastoma (GBM) is a highly aggressive tumor of the central nervous system, corresponding to grade IV of the World Health Organization histological classification (Louis et al., 2007). High grade gliomas are the most common primary brain tumor in adults, with an incidence of 3.1 per 100,000 person-year in the USA and the median survival times of 14.6 months (Stupp et al., 2005) after first occurrence and 11.9 after the first re-resection (Quick et al., 2014). Against to this pathology, we proposed (Borasi et al., 2014) the use of high intensity focused ultrasound (HIFU). (Source: Physica Medica: European Journal of Medical Physics)



Editorial Comment

Mon, 01 Feb 2016 00:00:00 +0100

Clinical utility of multiparametric (MP) prostate magnetic resonance imaging (MRI) has been shown for detection of clinically significant disease, benign lesions from neoplasia, and assessing disease burden.1 There are clear implications for a transformation in the way we screen, risk stratify, surveil, and treat patients. There is also potential to identify at-risk patients for prevention studies and to further the field of partial-prostate therapy such as radiation, high-intensity focused ultrasound, and laser ablation. (Source: Urology)



Experimental ultrasound treatment zaps cancer pain

Fri, 29 Jan 2016 23:25:41 +0100

High-intensity focused ultrasound blasts cells that trigger pain; "When the pain is less, or the pain is gone, you're back to being normal" (Source: Health News: CBSNews.com)



Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration

Wed, 20 Jan 2016 00:00:00 +0100

In this study, the effects of pulsed HIFU (pHIFU) parameters (spatial-average pulse-average intensity, duty factor and pulse repetition frequency) on the penetration as well as content of small molecules were evaluated in ex vivo porcine kidneys. (Source: Ultrasound in Medicine and Biology)

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A review of ablative techniques in the treatment of breast fibroadenomata

Tue, 19 Jan 2016 00:00:00 +0100

Conclusion Minimally invasive ablative techniques like HIFU, cryo-ablation and laser ablation are promising in the treatment of breast FAD. Future trials should be randomised and contain larger numbers of patients to determine the effectiveness of ablative techniques with more precision. (Source: Journal of Therapeutic Ultrasound)



High-Intensity Focused Ultrasound for the Treatment of Wrinkles and Skin Laxity in Seven Different Facial Areas.

Mon, 18 Jan 2016 06:58:05 +0100

CONCLUSION: HIFU could be a safe, effective, and noninvasive procedure that can be used to improve facial wrinkles and skin laxity in Asian skin. It is particularly effective for clinical improvement in the jawline, cheek, and perioral areas. PMID: 26719637 [PubMed] (Source: Annals of Dermatology)



Effect of High-Intensity Focused Ultrasound on Drug Release from Doxorubicin-Loaded PEGylated Liposomes and Therapeutic Effect in Colorectal Cancer Murine Models

Mon, 18 Jan 2016 00:00:00 +0100

The goal of the study described here was to evaluate the use of high-intensity focused ultrasound (HIFU) in drug release and its application in cancer therapy. HIFU was set to minimize hyperthermia, particularly non-specific hyperthermia, of exposed areas. An in vitro temperature-sensitive hydrogel phantom model determined the parameters of HIFU under mild condition settings (spatial average temporal average intensity [ISATA] = 83.35 W/cm2). PEGylated liposomal indocyanine green (LCLP-ICG) and PEGylated liposomal doxorubicin (LCLP-Dox) were prepared with the same mole ratio to allow direct comparison of drug release in vitro and in vivo. (Source: Ultrasound in Medicine and Biology)



Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Osteoid Osteoma: A Case Series Report

Sat, 16 Jan 2016 00:00:00 +0100

Osteoid osteoma is painful benign tumor. The aim of this study was to report our initial experience using magnetic resonance-guided focused ultrasound to treat osteoid osteomas. This retrospective single-center study included four patients treated with magnetic resonance-guided focused ultrasound. They presented with severe pain with reduced quality of life and a poor response to clinical treatment. The pre- and post-treatment evaluation comprised computed tomography and magnetic resonance imaging and focused on quality of life and the impact of pain on daily activities. (Source: Ultrasound in Medicine and Biology)



Use of cryoablation beyond the prostate

Wed, 13 Jan 2016 00:00:00 +0100

Abstract Cryoablation has been used for many years as a surgical ablation technique in the prostate and kidney. However, since the introduction of high-intensity focused ultrasound (HIFU) and robotic surgery for prostate tumours, its popularity in the urologic community has declined. In the early 2000s, innovations in cryoablation technology allowed the use of thinner probes, which were suitable for percutaneous application. As a result, radiologists began using cryoablation, first in the liver, and then in other organs or tissues such as the kidney, lung, breast, pancreas, bone, and soft tissue. In most of these locations, cryoablation has great potential given its inherent advantages, including the use of local anaesthesia, little or no pain during and after the procedure, real...

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Grains unchained: local fluidization of a granular packing by focused ultrasound

Tue, 12 Jan 2016 02:16:18 +0100

We report experimental results on the dynamics of a granular packing submitted to high-intensity focused ultrasound. Acoustic radiation pressure is shown to remotely induce local rearrangements within a pile as...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)



Whole gland HIFU salvage ablation and focal HIFU salvage treatment

Tue, 12 Jan 2016 00:00:00 +0100

Publication date: January 2016 Source:European Urology Supplements, Volume 15, Issue 2 Author(s): M. Colombel, S. Crouzet, E. Baco, A. Gelet, E. Baco (Source: European Urology Supplements)



Focal Therapy for Prostate Cancer: An “À la Carte” Approach

Mon, 11 Jan 2016 00:00:00 +0100

Publication date: Available online 6 January 2016 Source:European Urology Author(s): Arjun Sivaraman, Eric BarretPersonalizing focal ablation energy for prostate cancer on the basis of cancer location is a novel concept. We propose the use of high-intensity focused ultrasound, cryotherapy, and brachytherapy for posterior, anterior, and apical tumors, respectively, to improve the overall outcome. This concept needs to be verified in prospective studies. (Source: European Urology)



Comparisons of oncological and functional outcomes among radical retropubic prostatectomy, high dose rate brachytherapy, cryoablation and high-intensity focused ultrasound for localized prostate cancer: A prospective, controlled, nonrandomized trial

Mon, 11 Jan 2016 00:00:00 +0100

Publication date: December 2015 Source:Urological Science, Volume 26, Issue 4 Author(s): Po-Hui Chiang, Yang Liu-Yi, Po-Yen Chen (Source: Urological Science)



Histopathology of breast cancer after magnetic resonance‐guided high intensity focused ultrasound and radiofrequency ablation

Tue, 05 Jan 2016 00:00:00 +0100

ConclusionHistopathologic differences between MR‐HIFU ablated tissue and RF ablated tissue were demonstrated. CK8 was more reliable for cell viability assessment than H&E when used directly after ablation, while H&E was more reliable in ablated tissue left in situ for a few days. Our results contribute to improved understanding of histopathologic features in breast cancer lesions treated with minimally invasive ablative techniques.This article is protected by copyright. All rights reserved. (Source: Histopathology)

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Clinical Predictors of Long-term Success in Ultrasound-guided High-intensity Focused Ultrasound Ablation Treatment for Adenomyosis: A Retrospective Study

Fri, 01 Jan 2016 06:00:00 +0100

Abstract: The long-term outcomes of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation treatment for adenomyosis and the relevant factors affecting the durability of symptom relief were assessed in this study. A total of 230 women with adenomyosis who were treated with USgHIFU ablation between January 2007 and December 2013 were retrospectively analyzed. The contrast-enhanced ultrasonography (CEUS) was performed immediately after the treatment to evaluate the ablation effect, and the nonperfused volume (NPV) ratio was then calculated. Regular follow-up was conducted and the visual analog scale (VAS) score was used to assess the changes in dysmenorrhea. The effect of treatment was evaluated after an average follow-up length of 3 months and the factors affecting clinical...



Non-invasive magnetic resonance-guided high intensity focused ultrasound ablation of a vascular malformation in the lower extremity: a case report

Wed, 30 Dec 2015 00:00:00 +0100

Conclusions In conclusion, we reported a successful non-invasive treatment of a vascular malformation with MR-HIFU in a clinical patient including long-term follow-up data for the first time. The patient reported qualitatively sustained pain reduction up to 13 months post treatment. (Source: Journal of Therapeutic Ultrasound)



Ultrasound responsive block copolymer micelle of poly(ethylene glycol)-poly(propylene glycol) obtained through click reaction.

Mon, 28 Dec 2015 15:24:09 +0100

Authors: Li F, Xie C, Cheng Z, Xia H Abstract The well-defined amphiphilic poly(ethylene glycol)-block-poly(propylene glycol) copolymer containing 1, 2, 3-triazole moiety and multiple ester bonds (PEG-click-PPG) was prepared by click reaction strategy. The PEG-click-PPG copolymer can self-assemble into spherical micelles in aqueous solution. It is found that high intensity focused ultrasound (HIFU) can open the copolymer PEG-click-PPG micelles and trigger the release of the payload in the micelle. The multiple ester bonds introduced in the junction point of the copolymer chain through click reactions were cleaved under HIFU, and leads to the disruption of the copolymer micelle and fast release of loaded cargo. The click reaction provides a convenient way to construct ultrasound res...



High intensity focused ultrasound as a tool for tissue engineering: Application to cartilage

Thu, 24 Dec 2015 00:00:00 +0100

In the field of tissue engineering there exists a need to generate tissues with specific local tissue properties so to match native tissue architecture and therefore gain true functionality. For example, engineered osteochondral grafts [1,2] are being investigated as an alternative to osteochondral allografts, which are of scarce supply [3,4]. Native tissue contains a mineralized subchondral plate, which anchors mature cartilage, separating it from the underlying vascularized bone, providing a virtually impermeable interface. (Source: Medical Engineering and Physics)



12 Amazing Things We Learned About The Human Body In 2015

Tue, 22 Dec 2015 12:15:55 +0100

The human body is a source of mystery. But every year, scientists get just a little better at understanding its secrets.  Of course, 2015 has been no different. In the past year, researchers have created better access to proven therapies, developed futuristic new technologies that may change the way we approach disease and even enacted more complete disease screening processes to keep us healthy.  Read on to learn more. Here’s to more scientific discoveries in 2016!   @media (max-width: 969px) { #desktop { display: none; } } @media (min-width: 970px) { #mobile { display: none; } } #g-body-desktop-graphic .graphic-hed { font-family: 'Source Sans Pro', Helvetica, sans-serif; font-size: 26px; line-height: 32px; font-weight: bold; padding: 5px 10px; } .graphic-h...

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Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MRgHIFU) for Treatment of Symptomatic Uterine Fibroids: An Economic Analysis.

Sun, 20 Dec 2015 21:10:21 +0100

CONCLUSIONS: Our findings suggest that MRgHIFU may be a cost-effective strategy at commonly accepted willingness-to-pay thresholds, after examining the uncertainty in model parameters and several likely scenarios. In terms of budget impact, the implementation of MRgHIFU could potentially result in one-year savings of $1.38 million and $4.15 million in the scenarios where MRgHIFU is implemented in 2 or 6 centres, respectively. From a patient perspective, it is important to consider that MRgHIFU is the least invasive of all fibroid treatment options for women who have not responded to pharmaceuticals; it is the only one that is completely noninvasive. Also important, from a societal point of view, is the potential benefit from faster recovery times. Despite these benefits, implementation of ...



Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MRgHIFU) Treatment of Symptomatic Uterine Fibroids: An Evidence-Based Analysis.

Sun, 20 Dec 2015 21:10:21 +0100

CONCLUSIONS: For women failing medical therapy and seeking alternatives to hysterectomy for symptomatic uterine fibroids, MRgHIFU provides a safe and effective, noninvasive, uterine-preserving treatment from which they rapidly recover. The treatment advantages of MRgHIFU are potentially offset by restrictive eligibility, lengthy procedure time, and dependence on availability of an MR device. The lack of comparative evidence between MRgHIFU and other, more established uterine-preserving treatments limits informed decision making among treatment options. PMID: 26357530 [PubMed - in process] (Source: Ontario Health Technology Assessment Series)



Screening Magnetic Resonance Imaging–Based Prediction Model for Assessing Immediate Therapeutic Response to Magnetic Resonance Imaging–Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids

Fri, 18 Dec 2015 21:48:39 +0100

Conclusions: Screening MRI-based prediction models for assessing immediate therapeutic responses of uterine fibroids to MR-HIFU ablation were fitted and validated, which may reduce the risk of unsuccessful treatment. (Source: Investigative Radiology)



Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report

Fri, 18 Dec 2015 00:00:00 +0100

Conclusion Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting. (Source: Journal of Therapeutic Ultrasound)



Proton Therapy as Salvage Treatment for Local Relapse of Prostate Cancer Following Cryosurgery or HIFU

Fri, 18 Dec 2015 00:00:00 +0100

Local recurrence of prostate cancer after cryosurgery (CS) or high-intensity focused ultrasound (HIFU) is an emerging problem as these treatments are increasingly offered in lieu of standard radiation therapy and surgery. In this small study, salvage proton therapy (PT) achieved a high rate of bPFS with acceptable toxicity and minimal changes in the IPSS and EPIC summary scores compared with baseline pre-PT function. (Source: International Journal of Radiation Oncology * Biology * Physics)

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Celsion wins Chinese approval for ThermoDox study

Wed, 16 Dec 2015 17:45:34 +0100

Oncology drug developer Celsion has won clinical trial approval from the China...Read more on AuntMinnie.comRelated Reading: FDA approves Philips, Celsion HIFU study Celsion, Philips resubmit MR-HIFU study Celsion, Focused Ultrasound support HIFU trials Philips, Celsion research program moves forward Philips inks research agreement with Celsion (Source: AuntMinnie.com Headlines)



Electrophysiological findings and long-term outcomes of percutaneous ablation of atrial arrhythmias after surgical ablation for atrial fibrillation [ADULT CARDIAC]

Tue, 15 Dec 2015 00:00:00 +0100

CONCLUSIONS Percutaneous treatment of highly symptomatic patients with unsuccessful previous surgical ablation is feasible, and relatively effective at the late follow-up. A multidisciplinary approach significantly improves the outcomes in these challenging patients. (Source: European Journal of Cardio-Thoracic Surgery)



EDAP Receives Russian Regulatory Approval for Focal One(R) HIFU Device

Fri, 11 Dec 2015 13:27:12 +0100

LYON, France, Dec. 11, 2015 -- (Healthcare Sales & Marketing Network) -- EDAP TMS SA (EDAP), the global leader in therapeutic ultrasound, today announced that Russia's Federal Service for Surveillance in Healthcare (Roszdravnadzor) has approved Focal One f... Devices, Oncology, Urology, RegulatoryEDAP TMS, Ablatherm, HIFU, prostate cancer (Source: HSMN NewsFeed)



FDA Clears Another High-Intensity Focused Ultrasound Treatment for Prostate Cancer

Thu, 03 Dec 2015 00:05:16 +0100

No abstract available (Source: Oncology Times - Current Table Of Contents)



Non-invasive transcranial brain ablation with high-intensity focused ultrasound.

Wed, 02 Dec 2015 21:40:54 +0100

Authors: Jenne JW Abstract The idea to ablate brain tissue with high-intensity focused ultrasound (HIFU) in a highly precise and localized manner is relatively old. For HIFU tissue ablation, ultrasound (US) waves are concentrated to a focal point. Due to US absorption, the focal area will be heated and consequently thermally destroyed. The spatial accuracy of the non-invasive procedure and the sharp delineation of the induced tissue lesions have led to the term 'focused ultrasound surgery' (FUS). The major obstacle for HIFU ablation in the brain is the skull bone, which absorbs most of the US energy and disturbs the focused US field. The development of large-sized phased array US transducers and adaptive focusing techniques based on computed tomography images have allowed these dif...

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Physical principles of microbubbles for ultrasound imaging and therapy.

Wed, 02 Dec 2015 21:40:54 +0100

Authors: Stride E Abstract Microbubble ultrasound contrast agents have been in clinical use for more than two decades, during which time their range of applications has increased to encompass echocardiography, Doppler enhancement, perfusion studies and molecular imaging, as well as a number of therapeutic applications, including drug delivery, gene therapy, high-intensity focused ultrasound treatments and sonothrombolysis. The aim of this article is to review the different types of microbubble agents, their physical behaviours and the mechanisms underlying their effectiveness in imaging and therapeutic applications. PMID: 25531659 [PubMed - indexed for MEDLINE] (Source: Frontiers of Neurology and Neuroscience)



Prior image based temporally constrained reconstruction algorithm for magnetic resonance guided high intensity focused ultrasound.

Tue, 01 Dec 2015 00:00:00 +0100

CONCLUSIONS: The PITCR approach is able to perform more accurate reconstructions of temperature maps compared to the TCR approach with highly undersampled data in MR guided high intensity focused ultrasound. PMID: 26632038 [PubMed - in process] (Source: Physica Medica)



Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction.

Mon, 30 Nov 2015 21:48:04 +0100

Authors: Krueger N, Mai SV, Luebberding S, Sadick NS Abstract In recent years, a number of modalities have become available for the noninvasive reduction of adipose tissue, including cryolipolysis, radiofrequency, low-level laser, and high-intensity focused ultrasound. Each technology employs a different mechanism of action to cause apoptosis or necrosis of the targeted adipocytes. Among these technologies, cryolipolysis has not only been commercially available for the longest time, but has also been best researched including in vitro and animal models and randomized controlled clinical trials in humans. The principle behind cryolipolysis exploits the premise that adipocytes are more susceptible to cooling than other skin cells. The precise application of cold temperatures triggers...



Feasibility, Safety, and Efficacy of Accurate Uterine Fibroid Ablation Using Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound With Shot Sonication

Wed, 25 Nov 2015 00:00:00 +0100

In conclusion, MRI-guided high-intensity focused US with shot sonication is a feasible, safe, and effective technique for ablation of uterine fibroids and complete ablation of T2-hypointense fibroids. (Source: Journal of Ultrasound in Medicine)



A prospective clinical trial of HIFU hemiablation for clinically localized prostate cancer

Tue, 24 Nov 2015 00:00:00 +0100

Authors: R van Velthoven, F Aoun, Q Marcelis, S Albisinni, M Zanaty, M Lemort, A Peltier & K Limani (Source: Prostate Cancer and Prostatic Diseases)

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Enhancement and quenching of high-intensity focused ultrasound cavitation activity via short frequency sweep gaps.

Mon, 23 Nov 2015 08:39:22 +0100

Authors: Hallez L, Lee J, Touyeras F, Nevers A, Ashokkumar M, Hihn JY Abstract This letter reports on the use of frequency sweeps to probe acoustic cavitation activity generated by high-intensity focused ultrasound (HIFU). Unprecedented enhancement and quenching of HIFU cavitation activity were observed when short frequency sweep gaps were applied in negative and positive directions, respectively. It was revealed that irrespective of the frequency gap, it is the direction and frequency sweep rate that govern the cavitation activity. These effects are related to the response of bubbles generated by the starting frequency to the direction of the frequency sweep, and the influence of the sweep rate on growth and coalescence of bubbles, which in turn affects the active bubble populatio...



Characterization of HIFU transducers designed for sonochemistry application: Acoustic streaming.

Mon, 23 Nov 2015 08:38:17 +0100

Authors: Hallez L, Touyeras F, Hihn JY, Bailly Y Abstract Cavitation distribution in a High Intensity Focused Ultrasound sonoreactors (HIFU) has been extensively described in the recent literature, including quantification by an optical method (Sonochemiluminescence SCL). The present paper provides complementary measurements through the study of acoustic streaming generated by the same kind of HIFU transducers. To this end, results of mass transfer measurements (electrodiffusional method) were compared to optical method ones (Particle Image Velocimetry). This last one was used in various configurations: with or without an electrode in the acoustic field in order to have the same perturbation of the wave propagation. Results show that the maximum velocity is not located at the focal...



Vaginal Pessary for Uterine Repositioning during High-Intensity Focused Ultrasound Ablation of Uterine Leiomyomas

Sat, 21 Nov 2015 01:57:29 +0100

In order to ensure safe magnetic resonance-guided, high-intensity focused, ultrasound ablation of uterine leiomyomas, the ultrasound beam path should be free of intervening scar and bowel. Pre-treatment MRI of a 9-cm long and 7.7-cm wide leiomyomatous uterus in a 39-year-old woman with menorrhagia and abdominopelvic pain initially demonstrated a focused ultrasound treatment path without a bowel between the uterus and the abdominal wall. On the day of ablation, however, multiple loops of bowel were observed in the ultrasound beam path by MRI. Uterine repositioning was accomplished with a 76-mm donut vaginal pessary, which anteverted the fundus and successfully displaced the bowel. A vaginal pessary may aid in repositioning an axial or retroverted uterus to enable ablation of uterine leiomyo...



Harmonic Motion Imaging (HMI) for Tumor Imaging and Treatment Monitoring.

Thu, 19 Nov 2015 03:04:01 +0100

Authors: Konofagou EE, Maleke C, Vappou J Abstract Palpation is an established screening procedure for the detection of several superficial cancers including breast, thyroid, prostate, and liver tumors through both self and clinical examinations. This is because solid masses typically have distinct stiffnesses compared to the surrounding normal tissue. In this paper, the application of Harmonic Motion Imaging (HMI) for tumor detection based on its stiffness as well as its relevance in thermal treatment is reviewed. HMI uses a focused ultrasound (FUS) beam to generate an oscillatory acoustic radiation force for an internal, non-contact palpation to internally estimate relative tissue hardness. HMI studies have dealt with the measurement of the tissue dynamic motion in response to an...



High intensity focused ultrasound ablation for atrial fibrillation: results from the National Spanish Registry.

Wed, 18 Nov 2015 13:27:28 +0100

CONCLUSIONS: The Spanish national registry showed an efficacy of AF ablation with the HIFU Epicor system of 66.1%, 63.8%, 63.9% and 45.9% at 6, 12, 24 and 36 months follow-up. There was no device-related complications. PMID: 26006216 [PubMed - as supplied by publisher] (Source: Minerva Cardioangiologica)

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Long-term outcomes after surgical ablation for atrial fibrillation in patients with continuous heart rhythm monitoring devices

Tue, 17 Nov 2015 00:00:00 +0100

CONCLUSIONS Continuous rhythm disclosure reveals that very small amounts of AF burden after surgical ablation are common. The preoperative duration of AF and the use of a box lesion only in patients with longer AF persistence history were independently associated with higher postoperative AF burden recurrence. The temporal AF pattern during the blanking period after ablation should be considered for further patient management and might serve as a prognostic factor. (Source: Interactive CardioVascular and Thoracic Surgery)



Edap slips shareholders lawsuit

Thu, 12 Nov 2015 14:50:46 +0100

Edap (NSDQ:EDAP) said yesterday that the appeal deadline lapsed for a shareholders lawsuit filed after an FDA advisory panel recommended against approval for its its Ablatherm device for treating prostate cancer. EDAP shares plunged last year after the FDA’s Gastroenterology & Urology Devices panel voted that the device did not appear to be effective or safe. Ablatherm, which won 510(k) clearance from the federal safety watchdog earlier this week, uses highhigh-intensity focused ultrasound to ablate prostate tissue. Shareholders sued in August 2014, accusing Edap of misleading investors by exaggerating Ablatherm’s safety and efficacy and understating adverse events. In September, a New York federal judge dismissed the case, ruling that the defendants failed to prove any ...



Application of acoustic droplet vaporization in ultrasound therapy

Wed, 11 Nov 2015 00:00:00 +0100

Abstract Microbubbles have been used widely both in the ultrasonic diagnosis to enhance the contrast of vasculature and in ultrasound therapy to increase the bioeffects induced by bubble cavitation. However, due to their large size, the lifetime of microbubbles in the circulation system is on the order of minutes, and they cannot penetrate through the endothelial gap to enter the tumor. In an acoustic field, liquefied gas nanoparticles may be able to change the state and become the gas form in a few cycles of exposure without significant heating effects. Such a phenomenon is called as acoustic droplet vaporization (ADV). This review is intended to introduce the emerging application of ADV. The physics and the theoretical model behind it are introduced for further understanding of...



High-Intensity Focused Ultrasound: Current Status for Image-Guided Therapy

Tue, 10 Nov 2015 00:00:00 +0100

Semin intervent Radiol 2015; 32: 398-415DOI: 10.1055/s-0035-1564793Image-guided high-intensity focused ultrasound (HIFU) is an innovative therapeutic technology, permitting extracorporeal or endocavitary delivery of targeted thermal ablation while minimizing injury to the surrounding structures. While ultrasound-guided HIFU was the original image-guided system, MR-guided HIFU has many inherent advantages, including superior depiction of anatomic detail and superb real-time thermometry during thermoablation sessions, and it has recently demonstrated promising results in the treatment of both benign and malignant tumors. HIFU has been employed in the management of prostate cancer, hepatocellular carcinoma, uterine leiomyomas, and breast tumors, and has been associated with success in limited...