Subscribe: MedWorm: Radiation Therapy
http://www.medworm.com/rss/medicalfeeds/therapies/Radiation-Therapy.xml
Added By: Feedage Forager Feedage Grade B rated
Language: English
Tags:
cancer  journal urology  patients  prostate cancer  prostate  radiation therapy  radiation  source journal  source  therapy 
Rate this Feed
Rate this feedRate this feedRate this feedRate this feedRate this feed
Rate this feed 1 starRate this feed 2 starRate this feed 3 starRate this feed 4 starRate this feed 5 star

Comments (0)

Feed Details and Statistics Feed Statistics
Preview: MedWorm: Radiation Therapy

MedWorm: Radiation Therapy



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Radiation Therapy category.



Last Build Date: Tue, 29 Mar 2016 16:20:34 +0100

 



Stereotactic body radiation therapy: A promising chance for oligometastatic breast cancer.

Mon, 28 Mar 2016 21:23:02 +0100

CONCLUSIONS: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate. PMID: 27017237 [PubMed - as supplied by publisher] (Source: Breast)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp40-12 long-term oncological outcomes of salvage radical prostatectomy for radio-recurrent/persistent prostate cancer after radiation therapy.

Mon, 28 Mar 2016 19:24:11 +0100

Radiation therapy is a commonly used primary treatment for clinically localized prostate cancer (PCa). The majority of patients who fail primary radiation therapy will receive palliative hormonal therapy. However, a number of patients will have persistent/recurrent cancer in the prostate only and will benefit from salvage extirpative or ablative local therapy. (Source: The Journal of Urology)



Mp50-01 survival analysis of patients with node positive prostate cancer after radical prostatectomy comparing observation vs. adjuvant androgen deprivation therapy alone vs. adjuvant androgen deprivation plus external beam radiation therapy.

Mon, 28 Mar 2016 19:24:10 +0100

The presence of lymph node metastasis (LNM) after radical prostatectomy (RP) is associated with poor survival. The optimal management of patients with LNM remains undefined. The aim of this study is to evaluate the association between three different management strategies and survival in prostate cancer with LNM after RP. (Source: The Journal of Urology)



Pd28-07 assessment of the rate of adherence to international guidelines of androgen deprivation therapy with external beam radiation therapy- a population-based study

Mon, 28 Mar 2016 19:24:10 +0100

The objective of the current study was to examine the rate of adherence to these guidelines within a large-scale population-based data repository. We hypothesized near-perfect guideline adherence. (Source: The Journal of Urology)



Mp50-08 can angiotensin-converting enzyme inhibitors reduce the incidence, severity, and duration of radiation proctitis?

Mon, 28 Mar 2016 19:24:09 +0100

To determine whether participants taking angiotensin-converting enzyme inhibitors (ACEIs) and treated with radical radiation therapy with neoadjuvant/adjuvant hormone therapy have less incidence, severity, and duration of radiation proctitis. (Source: The Journal of Urology)



Pd12-06 urinary diversion for complications of radiation therapy for the treatment of prostate cancer: updated results from the trauma and urologic research network of surgeons

Mon, 28 Mar 2016 19:24:08 +0100

To evaluate surgical outcomes after urinary diversion (UD) for complications of radiation therapy (XRT) for prostate cancer (CaP). (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp25-06 utilization of radiotherapy for prostate cancer according to urologists’ practice patterns

Mon, 28 Mar 2016 19:24:08 +0100

Physician practices that offer ancillary medical services may refer their patients for such services, a process known as self-referral. Self-referral for radiation therapy is prevalent in the urologic community, yet its impact on utilization and cost of prostate cancer care is not known. We evaluated how utilization and cost of care differ for men diagnosed with prostate cancer in a self-referring urologic practice (SRP) compared to a traditional urologic practice. (Source: The Journal of Urology)



Mp25-05 utilization of radiotherapy for prostate cancer according to urologists’ practice patterns

Mon, 28 Mar 2016 19:24:08 +0100

Physician practices that offer ancillary medical services may refer their patients for such services, a process known as self-referral. Self-referral for radiation therapy is prevalent in the urologic community, yet its impact on utilization and cost of prostate cancer care is not known. We evaluated how utilization and cost of care differ for men diagnosed with prostate cancer in a self-referring urologic practice (SRP) compared to a traditional urologic practice. (Source: The Journal of Urology)



Mp24-14 radiation therapy attenuates regeneration of the urothelium in novel cell culture radiation model

Mon, 28 Mar 2016 19:24:08 +0100

In this study, we aim to investigate the contribution of radiation-induced urothelial damage to the development of RC. We hypothesize that radiation exposure weakens the urothelial layer by reducing cellular proliferation, survival and differentiation ability of basal urothelial cells. (Source: The Journal of Urology)



Mp23-12 intraoperative radiation therapy during genitourinary surgery: the importance of specimen margin status in improving survival

Mon, 28 Mar 2016 19:24:08 +0100

Intraoperative radiation therapy (IORT) is used to provide effective local control (LC) for patients with locally advanced or recurrent tumors. Since 2006, our institution has performed IORT for pelvic and retroperitoneal soft tissue malignancies. We sought to assess outcomes of IORT cases in which there was genitourinary (GU) involvement. (Source: The Journal of Urology)



Pd33-09 pattern of metastatic spread after bladder-sparing therapy for invasive bladder cancer

Mon, 28 Mar 2016 19:24:08 +0100

The pattern of bladder cancer metastasis has been well described in the literature, with liver, lung, bone, and brain being the most common sites. We hypothesize that bladder sparing therapy with chemotherapy and external beam radiation therapy (XRT) alters the normal lymphatic drainage and leads to abnormal patterns of tumor metastasis. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp72-12 natural history and predictive factors for hospitalization in patients with radiation cystitis. results from a large retrospective study

Mon, 28 Mar 2016 19:24:05 +0100

Radiation therapy (RT) of the pelvis is the most common aetiology of non infectious hemorrhagic cystitis. The incidence rate ranges from 5 to 10% and the most common presenting symptom is gross haematuria. (Source: The Journal of Urology)



Mp04-19 a prospective study of health related quality of life outcomes for high risk prostate cancer patients managed by radical prostatectomy or radiation therapy with androgen deprivation therapy

Mon, 28 Mar 2016 19:24:04 +0100

We examined 3-year patterns in HRQoL of high risk CaP patients (National Comprehensive Cancer Network criteria) managed by radical prostatectomy (RP) or external beam radiation therapy (EBRT) with concurrent androgen deprivation therapy (ADT). (Source: The Journal of Urology)



Mp04-18 longitudinal regret and health-related quality of life following treatment for low- and intermediate-risk prostate cancer

Mon, 28 Mar 2016 19:24:04 +0100

This study compared PCa patients initially treated with radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BR), or active surveillance (AS) to assess the impact of treatment choice on decisional regret and HRQoL. (Source: The Journal of Urology)



Mp04-11 comparing quality of life outcomes in men receiving early versus late post-prostatectomy radiation therapy

Mon, 28 Mar 2016 19:24:04 +0100

Men with adverse pathologic features or biochemical recurrence after radical prostatectomy (RP) often receive subsequent radiation therapy (RT). The immediate post-operative deficits and slow recovery of urinary incontinence (UI) and sexual function (SF) over 2 years post-RP are well documented. Furthermore, RT may also significantly impact the recovery of UI and SF, particularly when combined with RP. As such, RT is often delayed until UI shows improvement. We sought to evaluate urinary and sexual quality of life (QOL) outcomes in RP patients to assess whether early RT administration was associated with worse outcomes. (Source: The Journal of Urology)



Mp06-07 incidence of bladder cancer after radiation for prostate cancer as a function of time and radiation modality

Mon, 28 Mar 2016 19:24:03 +0100

The influence of the radiation modality and the time point at which prostate cancer (PCa) patients are at increased risk of developing bladder cancer (BlCa) have not been clearly elucidated. We sought to evaluate the risk of BlCa developing after radiation therapy for PCa, stratified by ethnicity and follow-up duration. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp14-03 long-term outcomes of prostate brachytherapy

Mon, 28 Mar 2016 19:24:02 +0100

To determine which patient and treatment related factors influence biochemical, metastasis-fee (MF) and cause-specific (CSS) survival in men treated with prostate brachytherapy followed a minimum of 5 years. (Source: The Journal of Urology)



Mp14-02 oncological outcomes in patients with locally advanced prostate cancer treated with neoadjuvant endocrine and external beam radiation therapy followed by adjuvant continuous/intermittent endocrine therapy in an open-label, randomized, phase iii trial

Mon, 28 Mar 2016 19:24:02 +0100

To clarify the optimal treatment strategy on adjuvant androgen deprivation therapy (ADT) following to short-term neoadjuvant ADT and external beam radiation therapy (EBRT) in patients with locally advanced prostate cancer. (Source: The Journal of Urology)



Mp14-01 hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year oncologic outcomes of the dutch randomized phase 3 hypro trial

Mon, 28 Mar 2016 19:24:02 +0100

Hypofractionated radiotherapy might increase the radiobiological tumor dose without increasing toxicity due to the reported high radiation-fraction sensitivity of prostate cancer. Hypofractionated treatment is delivered in less fractions, offering both economic and logistical advantages. Here, we present the first results on oncologic outcome from the Dutch randomized HYPRO trial. (Source: The Journal of Urology)



Mp87-14 predictors of poor patient satisfaction following primary aus placement among men with and without a prior history of radiation

Mon, 28 Mar 2016 19:24:02 +0100

Artificial urinary sphincter (AUS) remains the gold standard treatment for men with stress urinary incontinence. Men with radiation therapy prior to AUS placement represent a group of patients with conflicting data regarding device outcomes which may influence patient satisfaction. There remains a dearth of information describing predictors of patient satisfaction amongst this group of patients. We aim to evaluate predictors of poor patient satisfaction among men undergoing primary AUS with and without a history of prior radiation. (Source: The Journal of Urology)



Mp87-09 prior radiation therapy decreases time to idiopathic erosion of artificial urinary sphincter: a multi-institutional analysis

Mon, 28 Mar 2016 19:24:02 +0100

Substantial controversy and conflicting data exists regarding artificial urinary sphincter (AUS) survival in patients with prior radiation therapy for treatment of prostate cancer. Herein we present data from a multi-institutional analysis revealing a marked decrease in AUS survival in post-prostatectomy patients significantly correlating to a history of radiation therapy. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp86-02 a prospective examination of erectile function preservation after radiation therapy

Mon, 28 Mar 2016 19:24:02 +0100

Prostate radiation (RT) is a known risk factor (RF) for erectile dysfunction (ED), mediating erectile dysfunction (ED) through endothelial changes, arteriosclerosis, and smooth muscle structural changes. Defining post-RT erectile function preservation (EFP) rates has been challenging due to a number of methodological challenges. The aim of this analysis was to assess EFP and its chronology in men treated with RT. (Source: The Journal of Urology)



Mp18-06 salvage external beam radiation therapy (ebrt) for local recurrence after high intensity focused ultrasound (hifu) failure versus salvage hifu for local recurrence after ebrt failure: a matched pair comparison

Mon, 28 Mar 2016 19:24:01 +0100

EBRT is one of the gold standard treatments for localized prostate cancer. High Intensity Focused Ultrasound (HIFU) is a new minimally invasive treatment option with promising outcomes. HIFU is one of salvage option after EBRT failure and EBRT is the standard salvage option for local relapse after HIFU. No randomized study is available to compare these two strategies of salvage treatment after a first line therapy. The goal was to evaluate the oncologic outcomes by using a matched pair analysis to compare patients treated with HIFU first + salvage EBRT (S-EBRT) versus EBRT first + salvage HIFU (S-HIFU) (Source: The Journal of Urology)



Pd05-01 microdissection testicular sperm extraction in patients with azoospermia due to chemotherapy

Mon, 28 Mar 2016 19:24:01 +0100

The recent advances in cancer therapies for males of pediatric, adolescent, and reproductive ages over the last several decades have led to increases in long-term survival, making post-treatment quality of life increasingly important. Combinations of surgery, radiation therapy, and chemotherapy may achieve high remission rates in patients with cancer, but the treatment can be harmful to male fertility. Cytotoxic chemotherapy may lead to irreversible spermatogenic dysfunction. Microdissection testicular sperm extraction (Micro-TESE) is the only method for fertility revival in chemotherapy induced azoospermic patients. (Source: The Journal of Urology)



Mp15-02 the effect of radical prostatectomy, external beam radiation therapy, and active surveillance on life insurance premiums in patients with prostate cancer

Mon, 28 Mar 2016 19:24:01 +0100

This study aims to determine how these different treatment options affect life insurance underwriting practices. (Source: The Journal of Urology)



Mp14-20 prostate imaging reporting and data system score before prostate biopsy can predict biochemical failure in prostate cancer patients treated with high-dose-rate brachytherapy

Mon, 28 Mar 2016 19:24:01 +0100

This study evaluated the utility of mp-MRI and PI-RADS score for predicting biochemical failure in prostate cancer patients treated with high-dose-rate (HDR) brachytherapy. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp14-19 the time elapsed between radical prostatectomy and post-operative radiotherapy has a significant impact on the subsequent erectile function recovery rates

Mon, 28 Mar 2016 19:24:01 +0100

Previous studies showed that the administration of radiotherapy (RT) after radical prostatectomy (RP) may be associated with a higher risk of side effects. In particular, early RT after surgery might substantially reduce the recovery of erectile function (EF). We hypothesized that shorter time intervals between surgery and RT can be associated with worse functional recovery (Source: The Journal of Urology)



Mp14-18 neglected sexual side effects to radiation therapy for prostate cancer

Mon, 28 Mar 2016 19:24:01 +0100

The aim of this analysis was to investigate orgasmic dysfunction, urinary incontinence during sexual activity (UIS), changes in penile morphology and sensory disturbances in the penis in prostate cancer patients treated with external beam radiation therapy (EBRT). (Source: The Journal of Urology)



Mp14-17 predicting erectile function following radiation therapy for prostate cancer at the point of care

Mon, 28 Mar 2016 19:24:01 +0100

The Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) is a one-page, 16-item questionnaire validated to measure patient-reported health related quality of life in prostate cancer (PC) patients at the point of care in the clinical setting. We previously developed and externally validated models predictive of intact sexual function, i.e. achieving an erection firm enough for intercourse, at two years following external beam radiation (EBRT) or brachytherapy (BT) using EPIC-26, the longer form parent tool from which EPIC-CP was derived (Alemozaffar M, et al., JAMA 306:1205-14, 2011). (Source: The Journal of Urology)



Mp14-16 increased prostate size and history of preoperative voiding dysfunction associated with greater urinary toxicity after post-prostatectomy adjuvant or salvage radiation

Mon, 28 Mar 2016 19:24:01 +0100

Animal models using the rabbit bladder have shown that outlet obstruction is associated with bladder fibrosis and diminished aerobic metabolism. Given that genitourinary toxicity in men undergoing radiation therapy (RT) after radical prostatectomy (RP) is related to ischemia, we set out to correlate the relationship between clinical factors affecting bladder circulation and urinary complications after RT. (Source: The Journal of Urology)



Mp14-15 clinico-dosimetric factors predicting long-term severe urinary incontinence after post-prostatectomy rt. results of a longitudinal observational study.

Mon, 28 Mar 2016 19:24:01 +0100

The fear of RT-induced urinary incontinence (URINC) often controindicates post-prostatectomy RT (POPRT), despite the lack of accurate data about its real incidence and severity. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp14-14 management of radiation therapy oncology group (rtog) grade 4 urologic complications of radiotherapy for prostate cancer

Mon, 28 Mar 2016 19:24:01 +0100

Grade 4 RTOG complications after radiotherapy (XRT) for prostate cancer (CaP) are purportedly rare; however, the literature is limited by short follow up and lack of surgical management outcomes. We hypothesized that grade 4 complications require complex surgical management with high morbidity. (Source: The Journal of Urology)



Mp14-13 cost-effectiveness analysis of adjuvant versus salvage radiotherapy after radical prostatectomy for high-risk disease

Mon, 28 Mar 2016 19:24:01 +0100

There is continued debate on adjuvant radiotherapy (ART) compared to observation plus salvage radiotherapy (SRT) after radical prostatectomy (RP) in men with adverse pathology (seminal vesicle invasion, positive surgical margins, extraprostatic extension). While three randomized clinical trials (SWOG 8794, EORTC 22911 and ARO 96-02) have consistently demonstrated improved PSA-free survival with ART, metastases and overall survival rates are inconsistent. Furthermore, if ART were given to all high risk post-RP patients, those who would have never had PSA recurrence would be overtreated with its attendant costs and impact on post-RP bowel, urinary and sexual function. (Source: The Journal of Urology)



Mp14-12 efficacy of early and delayed radiation in a prostatectomy cohort adjusted for genomic and clinical risk

Mon, 28 Mar 2016 19:24:01 +0100

In 3 published randomized clinical trials, adjuvant radiation therapy (ART) for prostate cancer (PCa) resulted in improved progression free survival. However, the impact on metastases and overall survival is unclear. To date, there have been no published prospective trials examining the impact of salvage radiation therapy (SRT) in this disease state. Hence, we conducted a retrospective, nonrandomized comparative study of adjuvant, salvage, or no radiation following radical prostatectomy (RP) for men with pT3 disease or positive margins (adverse pathologic features, APF). (Source: The Journal of Urology)



Mp14-11 when is the optimal timing for salvage radiation therapy in patients with increasing psa after radical prostatectomy? a patient risk stratification model based on prostate cancer aggressiveness

Mon, 28 Mar 2016 19:24:01 +0100

Salvage radiation therapy (SRT) represents a treatment option for patients with biochemical recurrence after radical prostatectomy (RP) and no evidence of distant metastasis. However, the optimal PSA level for SRT administration is still unclear, as data regarding clinically significant outcomes (such as distant metastasis) are still lacking. Therefore, we hypothesized that the impact of PSA level on cancer control after SRT varies according to tumour characteristics at final pathology (Source: The Journal of Urology)



Mp14-10 detrimental role of pre-prostatectomy neoadjuvant androgen deprivation in node-negative patients treated with adjuvant rt

Mon, 28 Mar 2016 19:24:01 +0100

To investigate a possible detrimental role of neoadjuvant hormonal therapy (NEOHT) prior to radical prostatctomy (RP) in a cohort of 513 node-negative patients (pts) treated with RP and adjuvant radiotherapy (ART) followed for more than 10 years. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp14-09 survival after conservative management versus external beam radiotherapy in very elderly patients with localized prostate cancer

Mon, 28 Mar 2016 19:24:01 +0100

In this study we compare survival in elderly men with localized PCa according to treatment type defined as radiotherapy (RT) with or without androgen deprivation therapy (ADT) vs. conservative management (observation). (Source: The Journal of Urology)



Mp14-08 long-term impact of adjuvant versus early salvage radiation therapy on clinical recurrence in pt3n0 prostate cancer patients treated with radical prostatectomy: results of a multi-institutional analysis

Mon, 28 Mar 2016 19:24:01 +0100

Three prospective randomised trials showed discordant results regarding the impact of adjuvant radiation therapy (aRT) relative to observation for metastasis-free and overall survival. Additionally, none of these trials systematically included patients who underwent early salvage radiation therapy (eSRT). We hypothesized that eSRT may be associated with similar cancer control rates compared to aRT (Source: The Journal of Urology)



Mp14-07 patterns and predictors of clinical recurrence following early salvage radiation therapy in patients with psa rise after radical prostatectomy: a long term multi-institutional analysis

Mon, 28 Mar 2016 19:24:01 +0100

Early salvage radiation therapy (eSRT) represents a treatment option for patients who experience PSA rise after radical prostatectomy (RP). Previous studies addressed the risk of biochemical failure after eSRT. However, data regarding hard clinical endpoints such as distant metastasis are still lacking. We aimed at assessing recurrence patterns and identifying predictors of clinical recurrence after eSRT (Source: The Journal of Urology)



Mp14-06 the impact of adjuvant radiotherapy on cancer-specific mortality in prostate cancer patients with seminal vesicle involvement: a competing-risks regression analysis

Mon, 28 Mar 2016 19:24:01 +0100

Prostate cancer (PCa) patients with seminal vesicle invasion (SVI) are at increased risk of recurrence and mortality after radical prostatectomy (RP). We aimed at assessing the impact of adjuvant radiotherapy (aRT) on cancer-specific mortality (CSM) in patients with SVI after adjusting for the risk of dying from other causes (Source: The Journal of Urology)



Mp14-05 post-salvage therapy, particularly with nadir psa

Mon, 28 Mar 2016 19:24:01 +0100

Androgen Deprivation Therapy (ADT) is associated with bothersome hot flashes, sexual dysfunction, psychological well being, cardiovascular toxicity, anemia, bone-loss, and skeletal-related events. Recent data suggests ADT to be detrimental, and may increase non-cancer related incidence of death. Many prostate cancer patients who fail after radiation therapy are routinely placed on ADT. Our aim is to assess whether salvage therapy may decrease and delay the need for ADT. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Mp14-04 outcomes of radiation following expectant management for low risk, localized prostate cancer

Mon, 28 Mar 2016 19:24:01 +0100

As more men are enrolled in active surveillance (AS) programs for low-risk, localized prostate cancer it is important to understand the prognosis of these men once and if they chose to undergo definitive treatment. Objective: To examine long-term outcomes of men diagnosed with low-risk, localized prostate cancer and who received radiation therapy (RT) post initial expectant management. (Source: The Journal of Urology)



Lb-s&t-33 prostate cancer treatment decision-making: quality vs quantity of life

Mon, 28 Mar 2016 19:24:00 +0100

The objective of this study was to evaluate the association between PCa treatment received and perceived treatment quantity and quality of life. (Source: The Journal of Urology)



Mp26-20 intravesical instillation of liposomal-tacrolimus (lp-10) is an effective treatment for chronic radiation cystitis

Mon, 28 Mar 2016 19:24:00 +0100

Radiation cystitis (RC) is a severe inflammatory condition of the bladder resulting from radiation therapy (RT) to the pelvic area. Current treatment options are inadequate due to poor treatment response and high recurrence rates. In a recent study, we demonstrated that intravesical instillation of the tacrolimus delivered in liposomal formulation in an acute rat RC model improved bladder function. Furthermore, in a compassionate use case study, the use of tacrolimus proved to be effective in treating a severe case of radiation-induced hemorrhagic cystitis. (Source: The Journal of Urology)



S&t-53 ten-year outcomes of treatment for localized prostate cancer in a single institution; comparison of radical prostatectomy vs radiation therapy ~propensity score matching analysis~

Mon, 28 Mar 2016 19:24:00 +0100

Radical prostatectomy (RP), intensity modulated radiation therapy (IMRT) and brachytherapy (BT) are three major definitive treatment modalities for localized prostate cancer in recent years. While a lot of technical progress are seen in this decade, patients with localized prostate cancer are often struggling with making a decision of their treatment. It might be due to luck of information in terms of comparing the outcomes among these modalities since only few reports are seen in the literature. (Source: The Journal of Urology)



S&t-25 androgen deprivation therapy in the context of dose escalating radiation: community practice patterns and outcomes

Mon, 28 Mar 2016 19:24:00 +0100

The role of Androgen Deprivation Therapy (ADT) has not been explicitly evaluated in the context of dose escalated external beam radiation therapy (EBRT). While benefits of ADT have shown improved survival for men with intermediate- to high-risk prostate cancer undergoing external beam radiation treatment (EBRT), contemporary trends in practice and outcomes in the community setting have not been well described. (Source: The Journal of Urology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Current Strategies and Future Directions in Classification and Treatment of Uterine Sarcomas

Mon, 28 Mar 2016 12:30:44 +0100

Uterine sarcomas comprise endometrial stroma tumors (EST) and uterine leiomyosarcomas (ULMS), with ESTs accounting for less than 2% and ULMS accounting for approximately 1% of uterine neoplasms. Recent classifications of ESTs denote as many as four categories: benign endometrial stromal nodule (ESN), low-grade endometrial stromal sarcomas (ESS), high-grade endometrial stromal sarcomas (HGESS), and undifferentiated uterine sarcomas (UUS). The designation UUS has been suggested to encompass undifferentiated endometrial sarcomas (UES) and undifferentiated uterine sarcomas of other tissue origins. The prognosis for ESS is good. Although a third of cases recur, the 5-year survival rate for Stage I disease can be as high as 98%. In contrast the prognosis for UES is poor, with a 5-year survival r...



Modeling and performance evaluation of a robotic treatment couch for tumor tracking.

Mon, 28 Mar 2016 04:34:01 +0100

Authors: Jöhl A, Lang S, Ehrbar S, Guckenberger M, Klöck S, Meboldt M, Daners MS Abstract Tumor motion during radiation therapy increases the irradiation of healthy tissue. However, this problem may be mitigated by moving the patient via the treatment couch such that the tumor motion relative to the beam is minimized. The treatment couch poses limitations to the potential mitigation, thus the performance of the Protura (CIVCO) treatment couch was characterized and numerically modeled. The unknown parameters were identified using chirp signals and verified with one-dimensional tumor tracking. The Protura tracked chirp signals well up to 0.2 Hz in both longitudinal and vertical directions. If only the vertical or only the longitudinal direction was tracked, the Protura tracked well...



Radiation therapy (with or without neck surgery) for phenotypic human papillomavirus–associated oropharyngeal cancer

Sun, 27 Mar 2016 22:00:00 +0100

CONCLUSIONSAccording to the low‐risk definition currently established in cooperative trials, the patients had a 2‐year PFS rate approximating 90%. When patients who were treated with radiation alone were evaluated, no compromise was observed in this high rate of PFS, which is higher than the 2‐year PFS thresholds used in current cooperative trials. Cancer 2016. © 2016 American Cancer Society. (Source: Cancer)



Jaw osteoradionecrosis and dental extraction after head and neck radiotherapy: A nationwide population-based retrospective study in Taiwan

Sun, 27 Mar 2016 22:00:00 +0100

Head and neck radiotherapy (R/T) combined (or not combined) with chemotherapy with/without surgery is the most effective way to ease the condition of head and neck cancers [1,2]. According to Chi et al., if head and neck R/T is applied, intensity-modulated radiation therapy (IMRT) or three-dimensional conformal radiation therapy (3D-CRT) is recommended [3]. (Source: Oral Oncology)



Radiodermatitis: A Review of Our Current Understanding

Sun, 27 Mar 2016 22:00:00 +0100

This article examines the current knowledge surrounding the pathogenesis, clinical manifestations, differential diagnoses, prevention, and management of radiodermatitis. Future research should examine therapies that incorporate the current understanding of the pathophysiology of radiodermatitis while measuring effectiveness using objective and universal outcome measures. (Source: American Journal of Clinical Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Coppock JD, Vermeer PD, Vermeer DW, Lee KM, Miskimins WK, Spanos WC, Lee JH Abstract Effective treatments for recurrent/metastatic human papillomavirus-positive (HPV+) head and neck squamous cell cancer (HNSCC) are limited. To aid treatment development, we characterized a novel murine model of recurrent/metastatic HPV+ HNSCC. Further analysis of the parental tumor cell line and its four recurrent/metastatic derivatives led to preclinical testing of an effective treatment option for this otherwise fatal disease. Reverse phase protein arrays identified key signaling cascades in the parental and recurrent/metastatic cell lines. While protein expression profiles differed among the recurrent/metastatic cell lines, activated proteins associated with the mTOR signaling cascade we...



Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma

Sat, 26 Mar 2016 23:00:00 +0100

In this study, we sought to identify predictors of bladder recurrence and overall survival after simple partial cystectomy. We included 27 patients with bladder tumor who received simple partial cystectomy without pelvic lymph node dissection between March 2000 and September 2013. Adjuvant chemotherapy or radiation therapy was prescribed according to the pathological results. Parameters were compared on the basis of bladder recurrence and overall survival. During a mean follow-up time of 39 months, five patients (18.5%) experienced bladder recurrence. An older age, a higher pathological stage, positive surgical margins, and distant metastases were significant predictors of overall survival (p = 0.031, p = 0.001, p = 0.001, and p = 0.011, respectively). Meanwhile, previous bladder ...



Difference in characteristics and outcomes between medullary breast carcinoma and invasive ductal carcinoma: a population based study from SEER 18 database.

Fri, 25 Mar 2016 17:33:04 +0100

In conclusion, MBC demonstrated more aggressive behavior but similar outcomes compared to IDC, which may be determined by prognostic factors such as breast subtype. These results not only confer deeper insight into MBC but contribute to individualized and tailored therapy, and thereby may improve clinical management and outcomes. PMID: 27009810 [PubMed - as supplied by publisher] (Source: Oncotarget)



Distance Matters for Quality Rectal Cancer Care

Fri, 25 Mar 2016 16:00:00 +0100

The farther a patient has to travel for radiation therapy, the less likely it will happen, study finds (Source: U.S. News - Health)



CE: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment

Fri, 25 Mar 2016 12:44:16 +0100

The American Cancer Society estimates that in 2014 nearly 16,000 U.S. children and adolescents developed cancer, and in roughly 1,200 of these cases the cancer was Hodgkin lymphoma (HL). The great majority of these patients will survive, joining the thousands who have been diagnosed and treated successfully in decades past. Nurses’ familiarity with and attention to the late effects of the chemotherapy and radiation therapy used to treat HL, which include breast cancer as well as cardiotoxicity and its sequelae, are essential in helping these patients maintain their overall health. (Source: AJN)



Distance Matters for Quality Rectal Cancer Care

Fri, 25 Mar 2016 12:00:34 +0100

FRIDAY, March 25, 2016 -- Patients who must travel long distances for rectal cancer radiotherapy are less likely to get the potentially lifesaving treatment, a new study shows. "Travel burden clearly creates a barrier to radiation therapy access for... (Source: Drugs.com - Daily MedNews)



Varian opens office in Algeria

Fri, 25 Mar 2016 07:00:00 +0100

Radiation therapy firm Varian Medical Systems has expanded its operations in...Read more on AuntMinnie.comRelated Reading: Varian launches new Beacon transponder Varian preps new products for ECR 2016 Varian posts mixed Q1 results Varian gets Saudi OK for proton therapy system Varian sees slight revenue increase in 2015 (Source: AuntMinnie.com Headlines)



Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction

Thu, 24 Mar 2016 23:00:00 +0100

by Qinghao Zhang, Mei Gao, Guifen Luo, Xiaofeng Han, Wenjing Bao, Yanyan Cheng, Wang Tian, Maocai Yan, Guanlin Yang, Jing An Radiation therapy is an important treatment choice for unresectable advanced human lung cancers, and a critical adjuvant treatment for surgery. However, radiation as a lung cancer treatment remains far from satisfactory due to problems associated with radiation resistance in cancer cells and severe cytotoxicity to non-cancer cells, which arise at doses typically administered to patients. We have recently identified a promising novel inhibitor of β-catenin/Tcf4 interaction, named BC-23 (C21H14ClN3O4S), which acts as a potent cell death enhancer when used in combination with radiation. Sequential exposure of human p53-null non-small cell lung cancer (NSCLC) H1299 cel...



Recent Advances in the Concept of Radiation Therapy of Brain Metastases: Dawn of the Radiosurgery Era

Thu, 24 Mar 2016 23:00:00 +0100

(Source: World Neurosurgery)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Distance Matters for Quality Rectal Cancer Care

Thu, 24 Mar 2016 23:00:00 +0100

The farther a patient has to travel for radiation therapy, the less likely it will happen, study finds (Source: The Doctors Lounge - Oncology)



AHNS Series: Do you know your guidelines?Principles of radiation therapy for head and neck cancer: A review of the National Comprehensive Cancer Network guidelines

Thu, 24 Mar 2016 23:00:00 +0100

This article is a continuation of the “Do You Know Your Guidelines” series, an initiative of the American Head and Neck Society's Education Committee to increase awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network guidelines for radiotherapy in the treatment for head and neck cancers are reviewed here in a systematic fashion according to site and stage. These guidelines outline indications for primary and adjuvant treatment, as well as general principles of radiotherapy. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Peptide Receptor Radiation Therapy for Neuroendocrine Tumors.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007143 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Axillary coverage by whole breast irradiation in 1 to 2 positive sentinel lymph nodes in breast cancer patients.

Thu, 24 Mar 2016 12:07:02 +0100

CONCLUSIONS: Results of our analysis showed that standard 3D tangential whole breast irradiation failed to deliver a therapeutic dose to axillary levels I and II. The coverage was even lower using static and volumetric IMRT techniques. PMID: 27002946 [PubMed - as supplied by publisher] (Source: Tumori)



PET/CT after therapy avoids surgery for head, neck cancer

Thu, 24 Mar 2016 07:00:00 +0100

Using PET/CT scans to assess response to therapy can help patients with head...Read more on AuntMinnie.comRelated Reading: 3-month PET/CT helps track oropharyngeal cancer Interrupted radiation therapy risks cancer recurrence PET/CT details hint at survival of head and neck cancer patients Oral HPV infection increasing in young men PET/CT prevents dissections for head and neck cancer patients (Source: AuntMinnie.com Headlines)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Assessment of the Double-Staple Technique for Esophagoenteric Anastomosis in Gastric Cancer

Thu, 24 Mar 2016 01:35:19 +0100

Conclusion In the largest Western series of DST for esophagoenteric anastomoses in gastric cancer surgery, our experience demonstrates that DST is safe and effective with low rates of leak and stricture. (Source: Journal of Gastrointestinal Surgery)



Xanthogranuloma in the heavily irradiated low neck in a patient with head and neck cancer

Thu, 24 Mar 2016 00:00:00 +0100

Head and neck cancer is often managed with a combination of surgery, radiation therapy, and chemotherapy, and skin toxicity is not uncommon. Xanthogranuloma is a pathological finding resulting from an inflamma... (Source: Journal of Otolaryngology - Head and Neck Surgery)



Evaluation of the incident directional dependence of radiochromic film by use of Monte Carlo simulation and measurement

Wed, 23 Mar 2016 23:00:00 +0100

Abstract In high-precision radiotherapy, absolute and relative doses are evaluated for patient-specific intensity-modulated radiation therapy (IMRT) quality assurance (QA). In our institution, we use GAFCHROMIC EBT3 (EBT3) for relative dose evaluation in IMRT QA. We usually use two directional film configurations, which are in the axial and sagittal planes. The QA in our institution shows some differences between the gamma pass rates in the axial and sagittal directions. The purpose of this study was to evaluate the incident directional dependence of EBT3 by using the percent depth dose (PDD) and the off-center ratio (OCR) between EBT3 films positioned perpendicular to the beam axis and along the beam axis. Furthermore, we compared the PDD in EBT3 films positioned perpendicular to...



Simple Factors Associated with Radiation-Induced Lung Toxicity after Stereotactic Body Radiation Therapy of the Thorax: A Pooled Analysis of 88 Studies

Wed, 23 Mar 2016 23:00:00 +0100

Risk factors for radiation-induced lung toxicity (RILT) after stereotactic body radiotherapy (SBRT) were analyzed from 88 published studies (7752 patients). The overall rate of RILT is relatively low after thoracic SBRT. Adverse risk factors for RILT after SBRT include older age, larger tumor size and greater lung dose-volume exposure as measured by mean lung dose and volume of lung receiving greater than 20 Gy. (Source: International Journal of Radiation Oncology * Biology * Physics)



Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL): An International Lymphoma Radiation Oncology Group (ILROG) Multi-institutional Experience

Wed, 23 Mar 2016 23:00:00 +0100

pcALCL is radiosensitive tumor with 95% CCR. Most ILROG members used doses in the range of 30-39 Gy. However, lower doses also appear effective, regardless of T stage. (Source: International Journal of Radiation Oncology * Biology * Physics)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Stereotactic Radiotherapy for Spinal Metastases in the Postoperative Setting: A Secondary Analysis of Mature Phase I-II Trials

Wed, 23 Mar 2016 23:00:00 +0100

We evaluated the outcomes of patients with spinal metastases treated with postoperative stereotactic body radiation therapy (SBRT) on prospective phase I-II protocols and found durable rates of treated tumor control (TC) after a long median follow-up. Despite the fact that the majority of patients had radioresistant tumors and almost half received prior spinal radiation therapy, the 1-year TC was 85% and there was minimal neurologic toxicity observed. Thus, postoperative SBRT offers a favorable risk/benefit ratio. (Source: International Journal of Radiation Oncology * Biology * Physics)



QOL Outcomes from a Phase II Trial of Short Course Radiotherapy Followed by FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer

Wed, 23 Mar 2016 23:00:00 +0100

A regimen of 5 fractions of pelvic radiation therapy followed by 4 cycles of mFOLFOX6 [5-fluorouracil, oxaliplatin, leucovorin] was evaluated as a preoperative regimen for cT3-4 rectal cancer in a prospective phase II trial. Patient-reported QOL outcomes remained unchanged at 1-year post-treatment. QOL outcomes did not correlate with disease recurrence, pathologic complete response, pathologic T-stage downstaging or physician-documented toxicity. (Source: International Journal of Radiation Oncology * Biology * Physics)



Evidence-based Guideline Recommendations on Treatment Strategies for Localized Ewing’s Sarcoma of Bone following Neo-adjuvant Chemotherapy

Wed, 23 Mar 2016 23:00:00 +0100

(1) To provide recommendations regarding the choice of surgery, radiation therapy (RT), or the combination of surgery plus RT in patients with localized Ewing’s sarcoma of bone following neoadjuvant chemotherapy. (2) To determine the appropriate surgical planning imaging (pre-chemotherapy magnetic resonance imaging [MRI] or post-chemotherapy MRI) to identify optimal resection margins in patients with localized Ewing’s sarcoma who undergo surgery following neoadjuvant chemotherapy. (Source: Surgical Oncology)



The clinical management of inoperable endometrial carcinoma.

Wed, 23 Mar 2016 19:50:02 +0100

Authors: Mutch DG, Palisoul M Abstract Unresectable endometrial cancer, while rare, has a very poor prognosis, with a survival rate of 2 to 8 months. Although endometrial cancer is generally regarded as a survivable disease, the less common advanced and aggressive forms account for a large portion of endometrial cancer related deaths. Given the paucity of inoperable disease, randomized clinical data is lacking in this specific patient population. Management decisions regarding radiation therapy or systemic therapy are largely guided by the existing data in the setting of recurrence or second-line treatment, adjuvant therapy following optimal debulking, or in patients who are considered inoperable due to medical comorbidities rather than the extent of their disease. PMID: 269995...



Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions.

Wed, 23 Mar 2016 19:50:02 +0100

Authors: Myrehaug S, Sahgal A, Russo SM, Lo SS, Rosati LM, Mayr NA, Lock M, Small W, Dorth JA, Ellis RJ, Teh BS, Herman JM Abstract Despite advances in surgical, medical, and radiation therapy for pancreatic cancer, the prognosis remains poor. At this time, the only chance for long-term survival is surgical resection. More challenging is the optimal management of unresectable locally advanced pancreatic cancer, which has historically been treated with concurrent chemoradiation or chemotherapy alone. However, the survival and local control benefit of conventional radiotherapy in addition to chemotherapy was unclear. More recently, stereotactic body radiotherapy (SBRT) is emerging as a viable approach to maximizing local tumor control with a tolerable side effect profile. SBRT achiev...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




New technology may cut length of prostate cancer treatment

Wed, 23 Mar 2016 17:47:53 +0100

Stephen FellerSYDNEY, Austria, March 23 (UPI) -- A new technology could improve accuracy of prostate cancer radiation therapy, potentially cutting the number of treatments a patient needs from 40 to five. (Source: Health News - UPI.com)



Varian launches new Beacon transponder

Wed, 23 Mar 2016 07:00:00 +0100

Radiation therapy firm Varian Medical Systems has launched a Calypso 17-gauge...Read more on AuntMinnie.comRelated Reading: Varian preps new products for ECR 2016 Varian posts mixed Q1 results Varian gets Saudi OK for proton therapy system Varian sees slight revenue increase in 2015 Varian to develop radiotherapy training program in India (Source: AuntMinnie.com Headlines)



Choroidal melanoma initially treated as hemangioma: diagnostic and therapeutic considerations

Wed, 23 Mar 2016 04:26:49 +0100

Conclusion: Differentiating between amelanotic melanoma and choroidal hemangioma can be challenging. Relying solely on ophthalmoscopic features can be misleading. Ancillary studies such as indocyanine green and standardized A-scan ultrasonography bring clarity in differentiating circumscribed choroidal hemangioma from choroidal melanoma. Although cytology or histopathology is the only definitive method of establishing the diagnosis, careful emphasis on key diagnostic features can obviate the need for diagnostic fine-needle aspiration biopsy in most cases. (Source: Retinal Cases and Brief Reports)



Stereotactic Body Radiation Therapy as Salvage for Intrathoracic Recurrence in Patients With Previously Irradiated Locally Advanced Non–Small Cell Lung Cancer

Wed, 23 Mar 2016 00:15:31 +0100

Conclusions: We observed improved outcomes following SBRT as a means of salvage for locally advanced recurrent NSCLC over traditional radiation therapy options. The toxicities were greater than expected from naive lung irradiation, but the adverse effects remained controlled with medications. (Source: American Journal of Clinical Oncology)



Long-term Outcomes Following Radiation Therapy For Prostate Cancer Patients With Lymph Node Metastases at Diagnosis Treated With and Without Surgery

Wed, 23 Mar 2016 00:15:31 +0100

Conclusions: Patients diagnosed with PCa with LNI who were treated with RT with or without a prior surgery had relatively favorable long-term outcomes. (Source: American Journal of Clinical Oncology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Limitations of the Cancer of the Prostate Risk Assessment (CAPRA) Prognostic Tool for Prediction of Metastases and Prostate Cancer-specific Mortality in Patients Treated With External Beam Radiation Therapy

Wed, 23 Mar 2016 00:15:31 +0100

Objectives: To assess the performance of the Cancer of the Prostate Risk Assessment (CAPRA) prognostic tool for freedom-from-metastases (FFM) and cause-specific survival (CSS) in patients with localized prostate cancer treated with definitive external beam radiotherapy (EBRT), and to determine whether the performance of CAPRA is influenced by androgen deprivation therapy (ADT) use or the presence of Gleason pattern 5 (GP-5). Materials and Methods: A total of 612 patients from a prospective database of 718 patients treated with dose-escalated EBRT from 1998 to 2008 who met CAPRA scoring criteria were included in the study. Performance of CAPRA and association of CAPRA score, GP-5 and short-term or long-term ADT use (STAD or LTAD, respectively) with FFM and CSS were evaluated using Cox mode...



Treatment Outcomes in Very High-risk Prostate Cancer Treated by Dose-escalated and Combined-Modality Radiation Therapy

Wed, 23 Mar 2016 00:15:31 +0100

Conclusions: Dose-escalated EBRT or CMRT with long-term ADT resulted in favorable clinical outcomes for patients with VHRPC. (Source: American Journal of Clinical Oncology)



The prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy

Wed, 23 Mar 2016 00:00:00 +0100

The objective of this study is to evaluate patient outcome and prognostic factors in stage IVA cervical cancer treated wit... (Source: BMC Cancer)



Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions: Despite prior XRT for PCa, less than one-third of patients had no prostatic disease at the time of RC. Routine prostatic sampling should be considered in these patients especially if considering the orthotopic diversion. (Source: Urology Annals)



Proton Beam Radiation Therapy: The Future May Prove Brighter for Pediatric Patients With Brain Tumors [EDITORIALS]

Tue, 22 Mar 2016 23:00:00 +0100

(Source: Journal of Clinical Oncology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Comparing Intelligence Quotient Change After Treatment With Proton Versus Photon Radiation Therapy for Pediatric Brain Tumors [Pediatric Oncology]

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion PBRT was not associated with IQ decline or impairment, yet IQ slopes did not differ between the PBRT and XRT groups. It remains unclear if PBRT results in clinically meaningful cognitive sparing that significantly exceeds that of modern XRT protocols. Additional long-term data are needed to fully understand the neurocognitive impact of PBRT in survivors of pediatric brain tumors. (Source: Journal of Clinical Oncology)



A simple method of evaluating margin-growing accuracy in image-guided radiation therapy.

Tue, 22 Mar 2016 23:00:00 +0100

CONCLUSIONS: We have proposed a simple method to estimate margin-growing accuracy and suggested corrective action to minimize the variation. Advances in knowledge: One big difference from the previous results is that slice separation and pixel size both influence the accuracy of margin growth and volume calculation in Eclipse. PMID: 27007180 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)



Precise image-guided irradiation of small animals: a flexible non-profit platform.

Tue, 22 Mar 2016 23:00:00 +0100

We present a novel small animal image-guided radiation therapy (SAIGRT) system, which allows for precise and accurate, conformal irradiation and x-ray imaging of small animals. High accuracy is achieved by its robust construction, the precise movement of its components and a fast high-resolution flat-panel detector. Field forming and x-ray imaging is accomplished close to the animal resulting in a small penumbra and a high image quality. Feasibility for irradiating orthotopic models has been proven using lung tumour and glioblastoma models in mice. The SAIGRT system provides a flexible, non-profit academic research platform which can be adapted to specific experimental needs and therefore enables systematic preclinical trials in multicentre research networks. PMID: 27008208 [PubMed - a...



Former Toronto Mayor Rob Ford's Rare Abdominal Cancer, Explained

Tue, 22 Mar 2016 22:18:35 +0100

Rob Ford, the controversial former Toronto mayor who was known both for smoking crack cocaine in office and his intense popularity among conservative working-class voters, died today at the age of 46. The cause of death was not announced, but Ford was being treated for rare abdominal cancer called pleomorphic liposarcoma -- a diagnosis he received in 2014.  "It's rare to have a highly successful outcome with a pleomorphic liposarcoma once it's spread," Dr. Brian Van Tine, a medical oncologist at Washington University in St. Louis, told the Canadian Press.  Liposarcomas belong to a class of tumors that begin in the body's connective tissue and resemble fat cells. They are relatively uncommon, only affecting about 2,000 people per year in the United States, according to Memori...



Difficult preoperative diagnosis in a case of rapidly progressive carcinomatous pericarditis

Tue, 22 Mar 2016 20:13:19 +0100

Abstract A 54-year-old woman initially diagnosed with stage IIIb squamous cell carcinoma of the uterine cervix was treated with chemotherapy and radiation therapy. After 8 months, she developed dyspnea, leg edema, pleural effusion, pericardial effusion, and liver congestion. Her cardiac ejection fraction was normal and cardiomegaly was not evident. Metastatic carcinomatous pericarditis or pleurisy was suspected, but laboratory findings, including tumor markers, were normal. She was transferred to our hospital for the repair a cardiac injury caused by a pericardial drainage procedure. Emergency surgery was performed for the misplaced drainage catheter in the right atrium and for an abnormal mass in her right and left atria. The clinical diagnosis of carcinomatous pericarditis was...



Varian Launches New Smaller Calypso Beacon Transponder To Guide Radiation Therapy In Soft Tissue Tumors

Tue, 22 Mar 2016 14:04:18 +0100

New transponder receives FDA 510(K) clearance and CE Mark PALO ALTO, Calif., March 22, 2016 -- (Healthcare Sales & Marketing Network) -- Varian Medical Systems (VAR) today announced a new Calypso® 17G soft tissue Beacon® transponder that is 50 ... Devices, Oncology, FDA, Regulatory, Product LaunchVarian Medical Systems, Calypso, Beacon transponder, radiotherapy, radiosurgery (Source: HSMN NewsFeed)



In Reply to Leung

Tue, 22 Mar 2016 10:44:21 +0100

To the Editor: The letter from Dr Leung (1) regarding our article on radiation therapy in the Philippines (2) was gratefully received. There are more medical oncologists than radiation oncologists simply because there are more accredited training programs with available slots and therefore trainees. Why is this so? Chemotherapy drugs are easier to come by. There are a limited number of machines. We are very careful about the number of residents that we train. What would happen to our trainees if no hospital or facility would absorb them and provide an opportunity for practice? (Source: International Journal of Radiation Oncology * Biology * Physics)



In Regard to Nagata et al

Tue, 22 Mar 2016 10:44:21 +0100

To the Editor: I read with interest the article by Nagata et al (1) on stereotactic body radiation therapy (SBRT) in 100 inoperable and 64 operable patients with clinical stage T1N0M0 non-small cell lung cancer (NSCLC) treated with 48 Gy in 12 fractions. For the 100 inoperable patients, the 3-year overall survival (OS) rate was 59.9%, and for the 64 operable patients, the 3-year OS rate was 76.5%. Although the authors also provided corresponding data for a number of additional endpoints, the cancer-specific survival (CSS) data were missing. (Source: International Journal of Radiation Oncology * Biology * Physics)



In Regard to Bruner et al

Tue, 22 Mar 2016 10:44:21 +0100

To the Editor: We read the recent article by Bruner et al (1) with great interest. We congratulate the authors on performing this important analysis of accrual patterns in Radiation Therapy Oncology Group trials. As in previous studies of this topic (2), the authors demonstrated that minorities are dramatically underrepresented in clinical cancer trials. (Source: International Journal of Radiation Oncology * Biology * Physics)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Real-Time 3D Image Guidance Using a Standard LINAC: Measured Motion, Accuracy, and Precision of the First Prospective Clinical Trial of Kilovoltage Intrafraction Monitoring–Guided Gating for Prostate Cancer Radiation Therapy

Tue, 22 Mar 2016 10:44:21 +0100

Kilovoltage intrafraction monitoring (KIM) is a new real-time 3-dimensional image guidance method. Unlike previous real-time image guidance methods, KIM uses a standard linear accelerator without any additional equipment needed. The first prospective clinical trial of KIM is underway for prostate cancer radiation therapy. In this paper we report on the measured motion accuracy and precision using real-time KIM-guided gating. (Source: International Journal of Radiation Oncology * Biology * Physics)



Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence?

Tue, 22 Mar 2016 07:43:43 +0100

We present the case of a 10-year-old boy who is the first to undergo multiple-staged surgical resections alongside vincristine treatment. We performed a review of the literature analyzing the roles of radiation therapy, cytotoxic drugs, and novel targeted agents in JNA relapse. Small cohort studies suggest radiotherapy and flutamide are the most rational treatment options for residual and recurrent JNA. Our review highlights the need for further research into the management of primary and recurrent JNA. (Source: Journal of Pediatric Hematology Oncology)



Florida Cancer Affiliates First in the State Certified to Offer New Spacing Device to Benefit Prostate Cancer Patients

Tue, 22 Mar 2016 07:00:00 +0100

Trinity, Florida (March 22, 2016) - Florida Cancer Affiliates (FCA) is helping to pioneer a new tool aimed to protect prostate cancer patients from the negative effects of radiation therapy. Recently a patient, one of the first in Florida, was injected at FCA with SpaceOAR® hydrogel, the first FDA c... (Source: McKesson News)



Effects of radiation therapy on the structure and function of the pelvic floor muscles of patients with cancer in the pelvic area: a systematic review

Tue, 22 Mar 2016 05:36:46 +0100

Conclusion There is some evidence that RT has detrimental impacts on both PFMs’ structure and function. Implications for cancer survivors A better understanding of muscle damage and dysfunction following RT treatment will improve pelvic floor rehabilitation and, potentially, prevention of its detrimental impacts. (Source: Journal of Cancer Survivorship)



Severe myositis of the hip flexors after pre-operative chemoradiation therapy for locally advanced rectal cancer: case report

Tue, 22 Mar 2016 00:00:00 +0100

The use of neoadjuvant radiation therapy and chemotherapy in the treatment of locally advanced rectal adenocarcinoma has been shown to reduce disease recurrence when combined with surgery and adjuvant chemothe... (Source: BMC Cancer)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.




Outcomes of single‐ vs double‐cuff artificial urinary sphincter insertion in low‐ and high‐risk profile male patients with severe stress urinary incontinence

Mon, 21 Mar 2016 23:00:00 +0100

ConclusionsDistal bulbar DC insertion in patients with a ‘high‐risk’ profile (previous pelvic radiation, urethral surgery) leads to similar objective continence, but higher explantation rates when compared with patients considered ‘low risk’ with proximal bulbar SCs. Randomised controlled trials comparing both devices will be needed to determine whether the higher explanations rates are attributable to the DC device or to underlying risk factors. (Source: BJU International)