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MedWorm: Chronic Obstructive Pulmonary



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Chronic Obstructive Pulmonary category.



Last Build Date: Thu, 23 Apr 2015 15:38:43 +0100

 



The Prediction and Monitoring of Toxicity Associated with Long-Term Systemic Glucocorticoid Therapy

Thu, 23 Apr 2015 00:00:00 +0100

Abstract Glucocorticoids are often required for adequate control of inflammation in many serious inflammatory diseases; common indications for long-term treatment include polymyalgia rheumatica, giant cell arteritis, asthma and chronic obstructive pulmonary disease. Long-term glucocorticoid therapy is, however, associated with many adverse effects involving skin, gastro-intestinal, eye, skeletal muscle, bone, adrenal, cardio-metabolic and neuropsychiatric systems. This balance between benefits and risks of glucocorticoids is important for clinical practice and glucocorticoid-related adverse effects can significantly impair health-related quality of life. Understanding the nature and mechanisms of glucocorticoid-related adverse effects may inform how patients are monitored for tox...

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Single vs Bilateral Lung Transplant in IPF and COPDSingle vs Bilateral Lung Transplant in IPF and COPD

Wed, 22 Apr 2015 16:05:35 +0100

A new analysis looks at the benefits of using a single- vs double-lung transplant in patients with IPF or COPD. Medscape Pulmonary Medicine (Source: Medscape Today Headlines)



Factors leading to poor outcome of noninvasive positive pressure ventilation in acute exacerbation of chronic obstructive pulmonary disease

Wed, 22 Apr 2015 00:00:00 +0100

Conclusions In this study, NIPPV was successful in 77.4% cases and 22.6% cases were underwent endotracheal intubation. Pedal edema was the most common factor leading to poor outcomes while age >60 years was the least common factor, 66.2% and 24.2% respectively. (Source: Journal of Acute Disease)



Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease

Wed, 22 Apr 2015 00:00:00 +0100

ConclusionsInhaled LPS in COPD patients safely causes increased airway and systemic inflammation. This may be a model for studying COPD exacerbations. (Source: British Journal of Clinical Pharmacology)



New combination bronchodilators for chronic obstructive pulmonary disease: current evidence and future perspectives

Wed, 22 Apr 2015 00:00:00 +0100

Fixed dose combination (FDC) dual bronchodilators that co‐administer a long acting β2‐adrenoceptor agonist (LABA) and a long acting muscarinic antagonist (LAMA) are a new class of inhaled treatment for chronic obstructive pulmonary disease (COPD). This review focuses on the clinical evidence for the benefit of LABA/LAMA FDCs compared with monocomponent treatments, and also compared with active comparators that are widely used for the treatment of COPD, namely tiotropium and salmeterol‐fluticasone. Novel FDC dual bronchodilators include QVA149 and umeclidinium/vilanterol (UMEC/VI). Long term clinical trials show that QVA149 and UMEC/VI are superior to monocomponent therapy in terms of trough forced expiratory volume in 1 s (FEV1), although the FEV1 improvement was limited to approx...



Vit D Blog: Deficiency May Limit Airflow COPD

Tue, 21 Apr 2015 16:30:00 +0100

(MedPage Today) -- South Korean study explores effects on clinical characteristics of COPD patients. (Source: MedPage Today Endocrinology)

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Nocturnal non-invasive positive pressure ventilation for COPD

Tue, 21 Apr 2015 14:11:13 +0100

Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)



Engaging patients to recover life projectuality: an Italian cross-disease framework

Tue, 21 Apr 2015 11:34:50 +0100

Conclusions QoL deeply depends on the patient ability to engage in their care and on the health expectations they have. We propose a model of the relation between patient engagement and patients’ trajectories in critical event responses and use it to illustrate a new perspective on QoL. This research showed the heuristic value patient engagement as a is a key concept in the promotion of a patients’ experience-sensitive QoL interventions and assessment measures. (Source: Quality of Life Research)



Continuity of Care and Avoidable Hospitalizations for COPDContinuity of Care and Avoidable Hospitalizations for COPD

Tue, 21 Apr 2015 04:23:14 +0100

Can improved continuity of care result in fewer hospitalizations for patients with COPD? Journal of the American Board of Family Medicine (Source: Medscape Today Headlines)



Variation in causes of death in patients with non-small cell lung cancer according to stage and time since diagnosis

Tue, 21 Apr 2015 00:00:00 +0100

Conclusions With time, the relative contribution of cardiovascular and COPD causes of death increased, although the absolute contribution of lung cancer remained high in non-metastatic NSCLC. Therefore, managing morbidity of these diseases remains relevant. (Source: Annals of Oncology)



Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways

Tue, 21 Apr 2015 00:00:00 +0100

Conclusions RPL554 and glycopyrronium demonstrated a synergistic interaction in relaxing both human medium and small isolated bronchi, in terms of peak relaxation and an extended duration of action, suggesting that this combination may have a beneficial role in the treatment of asthma or COPD. (Source: Pulmonary Pharmacology and Therapeutics)

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Adverse Childhood Experiences & Post-traumatic Stress Disorder

Mon, 20 Apr 2015 17:45:51 +0100

Repeated adverse childhood experiences (ACEs) can change the body, brain, nervous system and ultimately an entire life. You may be incredibly resilient. The person with an easier life and more harmonious childhood may appear more resilient, but they have not been tested in the same ways. You may be an incredibly resourceful person — likewise, life has probably helped you hone these skills. You may be highly intelligent, empathic, kind or creative. You may feel very connected to your spiritual self. You may be navigating life from your heart and your smarts and yet wonder it’s not coming together for you. Trauma It’s a big word, trauma. We hear it most often when talking about returned service people who develop post-traumatic stress disorder (PTSD) after experiencing the horr...



Cigarette smoke-promoted acquisition of bacterial pathogens in the upper respiratory tract leads to enhanced inflammation in mice.

Mon, 20 Apr 2015 12:34:03 +0100

CONCLUSIONS: These findings demonstrate that exposure to CS impacts the ability of the host to control bacterial colonization of the upper airways, resulting in enhanced inflammation and susceptibility of the host to pathogens migrating into the lung. PMID: 25890119 [PubMed - as supplied by publisher] (Source: Respiratory Care)



Prevalence of chronic obstructive pulmonary disease and variation in risk factors across four geographically diverse resource-limited settings in Peru.

Mon, 20 Apr 2015 12:34:03 +0100

CONCLUSIONS: The burden of COPD in Peru was not uniform and, unlike other settings, was not predominantly explained by tobacco smoking. This study emphasizes the role of biomass fuel use, and highlights pulmonary tuberculosis as an often neglected risk factor in endemic areas. PMID: 25889777 [PubMed - as supplied by publisher] (Source: Respiratory Care)



Exon sequencing identifies a novel CHRNA3‐CHRNA5‐CHRNB4 variant that increases the risk for chronic obstructive pulmonary disease

Mon, 20 Apr 2015 12:06:55 +0100

ConclusionsThe present study identified a novel exon variant Ser140Gly, and two previously reported variants Tyr215Tyr and Asp398Asn are significantly associated with COPD risk in Chinese. These variants may be genetic biomarkers for predicting COPD risk in Chinese. Validation in other ethnicities is warranted. (Source: Respirology)



Vitamin D deficiency common in patients with lung disease

Mon, 20 Apr 2015 04:00:00 +0100

(Wiley) A new study from Korea has uncovered a high prevalence of vitamin D deficiency in individuals with chronic obstructive pulmonary disease (COPD), as well as a significant relationship between vitamin D deficiency and airflow limitations. Exercise capacity also tended to be decreased in participants with vitamin D deficiency. (Source: EurekAlert! - Medicine and Health)

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Dynamic hyperinflation during activities of daily living in COPD patients.

Mon, 20 Apr 2015 00:00:00 +0100

The objective of this study was to investigate whether some activities of daily living (ADLs) usually related to dyspnea sensation in patients with chronic obstructive pulmonary disease (COPD) are associated with dynamic lung hyperinflation (DH) and whether the use of simple energy conservation techniques (ECTs) might reduce this possible hyperinflation. Eighteen patients (mean age: 65.8 ± 9.8 years) with moderate-to-severe COPD performed six ADLs (walking on a treadmill, storing pots, walking 56 meters carrying a 5-kilogram weight, climbing stairs, simulating taking a shower, and putting on shoes) and had their inspiratory capacity (IC) measured before and after each task. The patients were moderately obstructed with forced expiratory volume in 1 second (FEV1): 1.4 ± 0.4 L (50% ± 12.4)...



Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis)

Mon, 20 Apr 2015 00:00:00 +0100

Repeated inhalative exposures to antigenic material from a variety of sources, mainly from moulds, thermophilic Actinomycetes, and avians, respectively, can induce immune responses with the clinical picture of extrinsic allergic alveolitis (EAA) or hypersensitivity pneumonitis. Delays of years or even decades till the diagnosis is made are not uncommon; frequent misdiagnoses include allergic asthma, COPD, recurrent flue and other infections. We provide here the state of the art references, a detailed case description and recommend a current diagnostics schema. (Source: Journal of Occupational Medicine and Toxicology)



Bioequivalence study of pregabalin

Sun, 19 Apr 2015 23:39:44 +0100

Tjandrawinata RR, Setiawati E, Putri RSI, Gunawan VA, Ong F, Susanto LW, Nofiarny D (Source: International Journal of COPD)



What clinical reasoning strategies do student paramedics use during their differentiation of patients with difficulty in breathing?

Sat, 18 Apr 2015 00:00:00 +0100

Conclusion Although a small study, consideration should be given to participants immature CRS; they may require post-registration support to develop consistently accurate and appropriate clinical decisions which avoid patient exposure to risk. Further research should identify whether other paramedic students, from the various registration routes, reflect these results. (Source: Emergency Medicine Journal)



A patient with respiratory distress

Sat, 18 Apr 2015 00:00:00 +0100

A 77-year-old male with a history of chronic obstructive pulmonary disease (COPD) and goitre presented to our emergency department with dyspnoea. The patient’s general practitioner had treated his COPD for a few days, but his symptoms persisted and he was referred for further treatment. His RR was 46 breaths/min and his SpO2 was 70% (figures 1 and 2). The patient was sedated and intubated with a curved laryngoscope blade, without alternative devices such as fiberoptic or video laryngoscope. Emergency left hemithyroidectomy was performed. A postoperative flow-volume loop revealed that the patient did not have COPD, suggesting all symptoms had been from the goitre (see online appendix figure 1). It is well known that patients tolerate large goitres over a long period and may have ...

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Derivation and validation of clinical phenotypes for COPD: a systematic review

Sat, 18 Apr 2015 00:00:00 +0100

Conclusions: The recognition that two phenotypes of COPD were often reported may have clinical implications for altering the course of the disease. This review also provided important information on limitations of phenotype studies in COPD and the need for improvement in future studies. (Source: Respiratory Research)



Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline

Sat, 18 Apr 2015 00:00:00 +0100

Conclusions: These results suggest an important role of the HHIP and FAM13A regions as genetic risk factors for COPD development and lung function decline in Chinese Han population. Future research on these genes should focus on the molecular mechanisms of these genes on developing COPD and creating therapies to alleviate reduced lung function. (Source: Respiratory Research)



Sicker from the start: copd exacerbation and distance to hospital

Sat, 18 Apr 2015 00:00:00 +0100

Discussion These results support our observation that COPD patients living a long way from hospital are sicker on arrival in ED: but they are sicker to start with. Almost everyone arrives at hospital approximately as sick as they were on ambulance arrival, the exception being a small subgroup living furthest from the hospital (35–40 miles). Our data are retrospective and preliminary: numbers are too small for statistical analysis. However, they suggest that COPD patients in rural areas are already sicker—possibly seeking help later—than those living nearby. A larger study is needed to confirm these results and investigate why: is it rural GPs, their patients, or both, who have a higher threshold for hospital admission than those living closer? Rural PHEM service planners ...



Using dynamics of forced expiration to identify COPD where conventional criteria for the FEV1/FVC ratio do not match

Fri, 17 Apr 2015 15:20:51 +0100

ConclusionsExpiratory flow dynamics can detect airflow limitation and indicate the presence of COPD. In discordant subjects, our methodology allows a better identification of subjects with or without characteristics of COPD. (Source: Respirology)



Protective and immunomodulatory effect of flos Lonicerae japonicae by augmenting IL-10 expression in a murine model of acute lung inflammation

Fri, 17 Apr 2015 00:00:00 +0100

Conclusions We demonstrated FLJ has protective activity against LPS-induced lung inflammatory cytokine release. Anti-inflammatory cytokine, IL-10, may prove beneficial in the treatment of endotoxin-associated lung inflammation. Graphical abstract (Source: Journal of Ethnopharmacology)

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Targeted therapy with inhaled corticosteroids in COPD according to blood eosinophil counts

Fri, 17 Apr 2015 00:00:00 +0100

Publication date: Available online 16 April 2015 Source:The Lancet Respiratory Medicine Author(s): Guy G Brusselle , Ken Bracke , Lies Lahousse (Source: The Lancet Respiratory Medicine)



The respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants.

Fri, 17 Apr 2015 00:00:00 +0100

Authors: Meyer M, Jaspers I Abstract The respiratory epithelium functions as a central orchestrator to initiate and organize responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory epithelium and are involved in respiratory homeostasis. Modifications to the protease/antiprotease balance can lead to the development of lung diseases such as emphysema or chronic obstructive pulmonary disease. Furthermore, altered protease/antiprotease balance, in favor for increased protease activity, is associated with increased susceptibility to respiratory viral infections such as influenza virus. However, nutritional antioxidants induce antiprotease expression/secretion and decrease protease expression/activity, to protect against viral infection. As such, this ...



Environmental fine particular matter and airway epithelium cell stress

Fri, 17 Apr 2015 00:00:00 +0100

Abstract Air pollution, especially the environmental particulate matter (PM), is known to have adverse effects on human health. The association between PM exposure and hospital admissions for COPD exacerbations has been widely reported. We focus on the effects of PM on airway epithelial cells and the role of oxidative stress in COPD. After exposure to PM2.5, oxidants and oxidative stress are increased in the epithelial cells. Increased oxidative stress plays an important role in COPD exacerbation by activating nuclear factor-kappaB (NF-kB) pathway. Oxidative stress also regulates epigenetic changes including histone modifications to contribute to increased inflammation and steroid resistance. We will discuss the potential therapeutic targets including antioxidants and epigenetic r...



Evaluation of the effectiveness of a home-based inspiratory muscle training programme in patients with chronic obstructive pulmonary disease using multiple inspiratory muscle tests.

Fri, 17 Apr 2015 00:00:00 +0100

CONCLUSIONS: A seven-week, community-based IMT programme, with realistic use of health-care resources, improves PImax and perception of well-being but a different design may be required for improvement in other measures. Multiple tests provide a more comprehensive evaluation of changes in muscle function post-IMT. Implications for Rehabilitation A seven-week, home-based inspiratory muscle training programme improves maximal inspiratory pressure and perception of well-being in patients with moderate to severe COPD but not sniff nasal inspiratory pressure or diaphragm contractility, respiratory muscle endurance and exercise capacity. Multiple tests are recommended for a more comprehensive assessment of changes in muscle function following inspiratory muscle training programmes. Therapists ne...



Clinical Decision-Making Tool for Safe and Effective Prescription of Exercise in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results From an Interdisciplinary Delphi Survey and Focus Groups.

Thu, 16 Apr 2015 00:00:00 +0100

CONCLUSIONS: AECOPD-MOB provides practical and concise information on safe and effective exercise for the AECOPD population for use by the new graduate or novice acute care practitioner. PMID: 25882485 [PubMed - as supplied by publisher] (Source: Physical Therapy)

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Pulmonary function abnormalities in adult patients with acute exacerbation of bronchiectasis: A retrospective risk factor analysis.

Thu, 16 Apr 2015 00:00:00 +0100

Authors: Ma Y, Niu Y, Tian G, Wei J, Gao Z Abstract Lung function impairments, especially airflow obstruction, are important features during acute exacerbation in patients with bronchiectasis. Recognition of the risk factors associated with airflow obstruction is important in the management of these exacerbations. The medical records of adult patients admitted to the Peking University People's Hospital, Beijing, China, from 2004 to 2011 with a diagnosis of bronchiectasis were reviewed retrospectively. Univariate and multivariate analyses were used to evaluate the risk factors associated with airflow obstruction. Airflow obstruction was found in 55.6% of 156 patients hospitalized with acute exacerbation of bronchiectasis, and the risk factors associated with airflow obstruction incl...



Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit.

Thu, 16 Apr 2015 00:00:00 +0100

We describe the epidemiological links between smoking and pulmonary disorders, the evidence for benefits of stopping smoking, how best to assess tobacco dependence and what interventions currently work best to help pulmonary patients quit. Finally, we describe characteristics and management of any "hardcore" smoker who finds it difficult to quit with standard approaches. PMID: 25882805 [PubMed - as supplied by publisher] (Source: Respiratory Care)



Airflow limitation by the Global Lungs Initiative equations in a cohort of very old adults.

Thu, 16 Apr 2015 00:00:00 +0100

Authors: Turkeshi E, Vaes B, Andreeva E, Matheï C, Adriaensen W, Van Pottelbergh G, Degryse JM Abstract The cut-off for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) defining airflow limitation for chronic obstructive pulmonary disease (COPD) is still contested. We assessed airflow limitation prevalence by the lower limit of normal (LLN) of Global Lungs Initiative (GLI) 2012 reference values and its predictive ability for all-cause mortality and hospitalisation in very old adults (aged ≥80 years) compared with the fixed cut-off. In a Belgian population-based prospective cohort of 411 very old adults, airflow limitation prevalence by the 5th percentile of GLI 2012 z-scores (GLI-LLN) and fixed cut-off (0.70) were compared with COPD reported by general prac...



The Editor recommends this issue's articles to the reader

Thu, 16 Apr 2015 00:00:00 +0100

See page 594: Relative contributions of emphysema and airway remodelling to airflow limitation in COPD: Consistent results from two cohorts NV Tho, Y Ryujin, E Ogawa, LTH Trang, R Kanda, K Goto, M Yamaguchi, T Nagao, LTT Lan and Y Nakano See page 633: Novel algorithm to identify and differentiate specific digital signature of breath sound in patients with diffuse parenchymal lung disease P Bhattacharya, A Mondal, R Dey, D Saha and G Saha (Source: Respirology)



A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle

Wed, 15 Apr 2015 00:00:00 +0100

β2-Agonist inhibitors can relieve chronic obstructive pulmonary disease (COPD) symptoms by stimulating cyclic AMP (cAMP) signaling. A-kinase-anchoring proteins (AKAPs) compartmentalize cAMP signaling by establishing protein complexes. We previously reported that the β2-agonist fenoterol, direct activation of protein kinase A (PKA), and exchange factor directly activated by cAMP decrease cigarette smoke extract (CSE)-induced release of neutrophil attractant interleukin-8 (IL-8) from human airway smooth muscle (ASM) cells. In the present study, we tested the role of AKAPs in CSE-induced IL-8 release from ASM cells and assessed the effect of CSE on the expression levels of different AKAPs. We also studied mRNA and protein expression of AKAPs in lung tissue from patients with COPD. O...

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Impaired exercise training-induced muscle fiber hypertrophy and Akt/mTOR pathway activation in hypoxemic patients with COPD

Wed, 15 Apr 2015 00:00:00 +0100

Exercise training (ExTr) is largely used to improve functional capacity in patients with chronic obstructive pulmonary disease (COPD). However, ExTr only partially restores muscle function in patients with COPD, suggesting that confounding factors may limit the efficiency of ExTr. In the present study, we hypothesized that skeletal muscle adaptations triggered by ExTr could be compromised in hypoxemic patients with COPD. Vastus lateralis muscle biopsies were obtained from patients with COPD who were either normoxemic (n = 15, resting arterial Po2 = 68.5 ± 1.5 mmHg) or hypoxemic (n = 8, resting arterial Po2 = 57.0 ± 1.0 mmHg) before and after a 2-mo ExTr program. ExTr induced a significant increase in exercise capacity both in normoxemic and hypoxemic patients with COPD. Howev...



Limitation in tidal volume expansion partially determines the intensity of physical activity in COPD

Wed, 15 Apr 2015 00:00:00 +0100

(Source: Journal of Applied Physiology)



Exercise limitation in chronic obstructive pulmonary disease. The o'donnell threshold.

Wed, 15 Apr 2015 00:00:00 +0100

Authors: Casaburi R, Rennard SI PMID: 25876202 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)



Chronic obstructive pulmonary disease part 1: smoking cessation.

Wed, 15 Apr 2015 00:00:00 +0100

Authors: Jones D Abstract Chronic obstructive pulmonary disease (COPD) is common in the UK and causes a significant burden to patients and the NHS. Healthcare provision for COPD is largely focused on biomedical treatment, yet research suggests the complexity of factors contributing to this disease requires a deeper understanding of the patient experience and a more holistic approach to the provision of care. Smoking cessation is the single most cost-effective and significant way to slow the disease progress and improve outcomes for patients. However, barriers to smoking cessation are higher in patients with COPD than in other groups, requiring different approaches. This is part one of a two-part article, which focuses on patients with COPD caused by smoking. The second part will fo...



HIV Infection Is Associated With Increased Risk for Acute Exacerbation of COPD

Tue, 14 Apr 2015 18:39:18 +0100

Background: Poorly controlled HIV infection is associated with increased risk for chronic obstructive pulmonary disease (COPD). Acute exacerbations of COPD (AECOPD) are major contributors to morbidity and mortality. Little is known about the association between HIV infection and AECOPD. Methods: We identified 167 individuals with spirometry-confirmed COPD from a longitudinal study of current or former injection drug users at risk or with HIV infection. AECOPD, defined as self-report of worsening breathing requiring treatment with antibiotics or steroids, was assessed at 6-month study visits. Multivariable logistic regression identified factors associated with AECOPD. Results: Of 167 participants, the mean age was 52 years; 89% were black, 30% female, and 32% HIV infected (median CD4 count:...

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Cigarette smoke alters the proteomic profile of lung fibroblasts

Tue, 14 Apr 2015 08:18:17 +0100

Mol. BioSyst., 2015, Accepted ManuscriptDOI: 10.1039/C5MB00188A, PaperClaudia D'Anna, Diego Cigna, Giorgia Costanzo, Andreina Bruno, Maria Ferraro, Serena Di Vincenzo, Laura Bianchi, Luca Bini, Mark Gjomarkaj, Elisabetta PaceSmoking is strongly associated with diseases such as lung cancer and chronic obstructive pulmonary disease (COPD). Lung fibroblasts are crucial for the integrity of alveolar structure by producing extracellular matrix...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)



The updates of overlapping syndrome: asthma and COPD

Tue, 14 Apr 2015 00:00:00 +0100

Abstract Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by heterogeneous chronic airway inflammation and airway obstruction. Airway obstruction is typically intermittent and reversible in asthma but is progressive and largely irreversible in COPD. However, there is a considerable pathologic and functional overlap between these two heterogeneous disorders, particularly among the elderly, who may have components of both diseases (asthma–COPD overlap syndrome, ACOS). A new chapter about ACOS is written in Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2014 and Global Initiative for Asthma (GINA) 2014. Here, we review the updates of ACOS. (Source: Current Respiratory Care ...



Lung cancer surgery in patients aged 80 years or older: an analysis of risk factors, morbidity, and mortality

Mon, 13 Apr 2015 13:16:56 +0100

Conclusions Thoracic surgery shows acceptable morbidity and mortality in patients 80 years of age or older. Patients 80 years of age or older should be offered the best treatments, including surgery, with careful patient evaluation and selection. (Source: General Thoracic and Cardiovascular Surgery)



Targeted lung denervation for moderate to severe COPD: a pilot study

Mon, 13 Apr 2015 00:00:00 +0100

Conclusions Bronchoscopic TLD, based on the concept of ablating parasympathetic pulmonary nerves, was feasible, safe, and well tolerated. Further investigation of this novel therapy is warranted. Trial registration number NCT01483534. (Source: Thorax)



Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis

Mon, 13 Apr 2015 00:00:00 +0100

We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference –0.37 (95% CI –0.50 to –0.24; I2=14%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed. (Source: Thorax)

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Accelerated ageing of the lung in COPD: new concepts

Mon, 13 Apr 2015 00:00:00 +0100

The rise in life expectancy worldwide has been accompanied by an increased incidence of age-related diseases, representing an enormous burden on healthcare services and society. All vital organs lose function with age, and this is well described in the lung, with a progressive decline in pulmonary function after the age of about 25 years. The lung ages, like any other organ, with progressive functional impairment and reduced capacity to respond to environmental stresses and injury. Normal physiological ageing results in enlarged alveolar spaces and loss of lung elasticity in the elderly known as ‘senile emphysema’, whereas in COPD there is destruction of the alveolar walls and fibrosis of peripheral airways. However, COPD shows striking age-associated features, such as an ...



Familial transmission of chronic obstructive pulmonary disease in adoptees: a Swedish nationwide family study

Mon, 13 Apr 2015 00:00:00 +0100

Conclusions The findings of the study show that the familial transmission of COPD is associated with COPD in biological but not adoptive parents, suggesting that genetic or early life factors are important in the familial transmission of COPD. (Source: BMJ Open)



Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases?

Mon, 13 Apr 2015 00:00:00 +0100

Macrolide antibiotics have been demonstrated to be efficacious in diverse chronic airway diseases characterised by neutrophilic airway inflammation, encompassing cystic fibrosis (CF), non-CF bronchiectasis, diffuse panbronchiolitis, exacerbation-prone COPD and neutrophilic severe asthma.1–8 Many exogenous and endogenous factors can elicit airway neutrophilia: infections (bacterial, viral, virus-like ...), pollution (smoking, indoor and outdoor air pollution) and other factors (eg, auto-immunity, gastro-oesophageal reflux with aspiration). Macrolides such as erythromycin, clarithromycin and azithromycin not only have antimicrobial properties, but also broad anti-inflammatory and immunomodulatory effects.9 The antimicrobial effects of macrolides include direct bacterial killing, the pr...



One-year change in health status and subsequent outcomes in COPD

Mon, 13 Apr 2015 00:00:00 +0100

Conclusions Patients with stable or improved health status during year 1 of ECLIPSE had a lower likelihood of exacerbation, hospitalisation or dying during 2-year follow-up. Interventions that stabilise and improve health status may also improve outcomes in patients with COPD. Trial registration number NCT00292552, registered at ClinicalTrials.gov. (Source: Thorax)



Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials

Mon, 13 Apr 2015 00:00:00 +0100

Publication date: Available online 12 April 2015 Source:The Lancet Respiratory Medicine Author(s): Steven Pascoe , Nicholas Locantore , Mark T Dransfield , Neil C Barnes , Ian D Pavord Background The short-term benefits of inhaled corticosteroids for patients with chronic obstructive pulmonary disease (COPD) are greater in patients with evidence of eosinophilic airway inflammation. We investigated whether blood eosinophil count is a useful biomarker of the long-term effect of the inhaled corticosteroid fluticasone furoate on exacerbation frequency. Methods We did a post-hoc analysis of data from two replicate, randomised, double-blind trials of 12 months' duration (Sept 25, 2009 to Oct 21, 2011 and Oct 17, 2011) in which once a day vilanterol 25 μg was compared with 25 μg vilanterol p...

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Vertebral compression fractures may increase mortality in male patients with chronic obstructive pulmonary disease

Sun, 12 Apr 2015 09:15:15 +0100

(Source: International Journal of Tuberculosis and Lung Disease)



Lung function and respiratory diseases in people with psychosis: population-based study.

Sat, 11 Apr 2015 22:30:03 +0100

Conclusions Schizophrenia is associated with impaired lung function and increased risk for pneumonia, COPD and chronic bronchitis. PMID: 25858177 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)



A new algorithm for the management of COPD

Sat, 11 Apr 2015 00:00:00 +0100

Publication date: April 2015 Source:The Lancet Respiratory Medicine, Volume 3, Issue 4 Author(s): Christopher B Cooper , Igor Barjaktarevic (Source: The Lancet Respiratory Medicine)



India revokes patent for COPD drug

Sat, 11 Apr 2015 00:00:00 +0100

Publication date: April 2015 Source:The Lancet Respiratory Medicine, Volume 3, Issue 4 Author(s): Dinesh C Sharma (Source: The Lancet Respiratory Medicine)



Predicting risk of COPD in primary care: development and validation of a clinical risk score.

Fri, 10 Apr 2015 20:24:05 +0100

CONCLUSIONS: Risk factors associated with COPD and routinely recorded in primary care have been used to develop and externally validate a new COPD risk score. This could be used to target patients for case finding. PMID: 25852945 [PubMed] (Source: Respiratory Care)

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Effectiveness of community-based integrated care in frail COPD patients: a randomised controlled trial.

Fri, 10 Apr 2015 15:56:02 +0100

CONCLUSION: The intervention improved clinical outcomes including survival and decreased the ED visits, but it did not reduce hospital admissions. The study facilitated the identification of two key requirements for adoption of IC services in the community: appropriate risk stratification of patients, and preparation of the community-based work force. PMID: 25856791 [PubMed - as supplied by publisher] (Source: Primary Care)



Burn injury associated with home oxygen use in patients with chronic obstructive pulmonary disease - Sharma G, Meena R, Goodwin JS, Zhang W, Kuo YF, Duarte AG.

Fri, 10 Apr 2015 13:48:23 +0100

OBJECTIVES: To quantify the risk of burn injury associated with home oxygen use and to examine the risk factors associated with the development of this injury. PATIENTS AND METHODS: We used a nested case-control and a retrospective cohort design to... (Source: SafetyLit: All (Unduplicated))



Dietary intake of patients with moderate to severe COPD in relation to fat-free mass index: a cross-sectional study

Fri, 10 Apr 2015 00:00:00 +0100

Background: Fat-free mass (FFM) depletion has been shown to be a better predictor of mortality than BMI in chronic obstructive pulmonary disease (COPD) patients. The specific aim of the current study was to assess the nutritional status of stable COPD patients in relation to fat free mass index profiles. Methods: We investigated 65 male moderate-to-severe stable COPD patients. A self-reported questionnaire was applied about general characteristics and smoking history. Nutritional intake was assessed by using a 54–item quantitative food frequency questionnaire. Weight, height, mid-upper arm circumference (MUAC), waist circumference (WC), handgrip strength and body composition measurements were taken by a trained dietitian. The data were analyzed with SPSS 15.0 software. Results: The mean ...



Risk factors associated with lower defecation frequency in hospitalized older adults: a case control study

Fri, 10 Apr 2015 00:00:00 +0100

Conclusions: Approximately 38% of hospitalized older adults had lower DF. AECOPD and use of muscle relaxant were significantly associated with lower DF; while supplementation of potassium and antibiotic use were protective for lower DF risk after adjusting for other variables. (Source: BMC Geriatrics)



Alcohol dependence and physical comorbidity: Increased prevalence but reduced relevance of individual comorbidities for hospital-based mortality during a 12.5-year observation period in general hospital admissions in urban North-West England.

Thu, 09 Apr 2015 01:00:05 +0100

CONCLUSION: The excess of in-hospital deaths in general hospitals in individuals with AD is due to an increase of multiple physical comorbidities, even though individual diseases have an equal or even reduced impact on general hospital-based mortality in individuals with AD compared to controls. PMID: 25841661 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)

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The impending epidemic of chronic cardiopulmonary disease and multi-morbidity: the need for new research approaches to guide daily practice.

Thu, 09 Apr 2015 00:00:00 +0100

Authors: Geersing GJ, de Groot JA, Reitsma JB, Hoes AW, Rutten FH Abstract Abstract: Mortality caused by acute cardiopulmonary disease is decreasing and in many countries the population is aging rapidly. Yet, the life-years gained are often spent with multiple chronic and slowly progressive conditions, and this particularly applies to cardiopulmonary patients. Affected individuals often have multiple diagnoses related to the cardio-pulmonary-metabolic axis with accelerated aging and gradually progressive failure of organs that provide the body with oxygen and nutrients. This more or less reflects an "engine running out of fuel". This, for instance, is the case with the concurrent presence of COPD and heart failure in one patient that is often combined with other co-morbidity such a...



Sesn2 and Pdgfr{beta} Expression [Signal Transduction]

Thu, 09 Apr 2015 00:00:00 +0100

We recently identified the antioxidant protein Sestrin 2 (Sesn2) as a suppressor of platelet-derived growth factor receptor β (Pdgfrβ) signaling and Pdgfrβ signaling as an inducer of lung regeneration and injury repair. Here, we identified Sesn2 and the antioxidant gene inducer nuclear factor erythroid 2-related factor 2 (Nrf2) as positive regulators of proteasomal function. Inactivation of Sesn2 or Nrf2 induced reactive oxygen species-mediated proteasomal inhibition and Pdgfrβ accumulation. Using bacterial artificial chromosome (BAC) transgenic HeLa and mouse embryonic stem cells stably expressing enhanced green fluorescent protein-tagged Sesn2 at nearly endogenous levels, we also showed that Sesn2 physically interacts with 2-Cys peroxiredoxins and Nrf2 albeit under different reductiv...



Clinical drug development using dynamic biomarkers to enable personalized health care in Chronic Obstructive Pulmonary Disease.

Thu, 09 Apr 2015 00:00:00 +0100

We describe research in COPD phenotypes, and the required characteristics of a suitable biomarker for identifying patients at higher risk of progression. We review the role of extra-cellular matrix proteins found to be upregulated in COPD. Novel biomarkers of connective tissue remodeling which may provide added value for a personalized approach by detecting subgroups of patients with active disease suitable for pharmacological intervention are discussed. PMID: 25856563 [PubMed - as supplied by publisher] (Source: Chest)



Efficacy of a Novel Method for Inspiratory Muscle Training in People With Chronic Obstructive Pulmonary Disease.

Thu, 09 Apr 2015 00:00:00 +0100

CONCLUSION: The short and largely home-based IMT protocol significantly improved inspiratory muscle function in both groups and is an alternative to traditional IMT protocols in this population. Patients in the TFRL-group tolerated higher training loads and achieved larger improvements in inspiratory muscle function than patients in the MTL group. PMID: 25858974 [PubMed - as supplied by publisher] (Source: Physical Therapy)



Non invasive ventilation as an additional tool for exercise training

Thu, 09 Apr 2015 00:00:00 +0100

Abstract Recently, there has been increasing interest in the use of non invasive ventilation (NIV) to increase exercise capacity. In individuals with COPD, NIV during exercise reduces dyspnoea and increases exercise tolerance. Different modalities of mechanical ventilation have been used non-invasively as a tool to increase exercise tolerance in COPD, heart failure and lung and thoracic restrictive diseases. Inspiratory support provides symptomatic benefit by unloading the ventilatory muscles, whereas Continuous Positive Airway Pressure (CPAP) counterbalances the intrinsic positive end-expiratory pressure in COPD patients. Severe stable COPD patients undergoing home nocturnal NIV and daytime exercise training showed some benefits. Furthermore, it has been repo...

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[Inflammation] How smoking makes infection worse

Thu, 09 Apr 2015 00:00:00 +0100

Smoking not only increases your risk of cancer but also increases inflammation and slows down recovery from infections, especially in people who have chronic obstructive pulmonary disorder – [Read More] (Source: Editors' Choice)



Impact of antibiotics on acute exacerbations of COPD

Thu, 09 Apr 2015 00:00:00 +0100

Conclusions In conclusion, this study has clearly shown that in type 1 exacerbations of COPD, antibiotic therapy, significantly results in decrease in duration of treatment, success rate and more rapid improvement in peak flow. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)



Eulogy For My Father

Wed, 08 Apr 2015 21:06:46 +0100

I thought I would get used to it. Maybe feel some callousness to it. Walking into the building and being directed to the viewing hall. Walking to the front of the room and seeing a loved one lying in a casket. I have seen a cousin, grandparents, uncles and friends within the last five years or so pass away. These past few months I have had to come to grips that I will again face death. My dad is dying! Twenty-four years ago my father suffered a near fatal stroke. The years following have been dealt with his heath declining and new issues he's faced including COPD and congestive heart failure. He has had a portable defibrillator installed in him in the event his heart stops. As I write this, he has been ordered to start hospice and is functioning on 30 percent of his heart. In preparing...



Impact of medical education program on COPD patients: a cohort prospective study.

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: This study reveals that an adequate medical education program is associated with a decreased rate of COPD-related hospitalizations. The implementation of a medical education program as an integrated part of therapy could lead to a more accurate self-management of the disease. PMID: 25851721 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)



Cardiovascular Disease And Diagnosis Of Amyotrophic Lateral Sclerosis: A Population-Based Study (P4.140)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: This is the first nationwide study to find positive associations between cardiovascular disease and ALS diagnosis. Our findings may have important implications about the pathogenesis of ALS. Study Supported by: 5R01 ES019188-02, NIH T32 ES007069Disclosure: Dr. Kioumourtzoglou has nothing to disclose. Dr. Seals has nothing to disclose. Dr. Gredal has nothing to disclose. Dr. Hansen has nothing to disclose. Dr. Weisskopf has received personal compensation in an editorial capacity for Environmental Health Perspectives. (Source: Neurology)

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Asthma Control and Cognitive Function in a Cohort of Elderly Adults

Wed, 08 Apr 2015 00:00:00 +0100

ConclusionPoor asthma control and airway obstruction are not associated with poor performance on various measures of cognitive function in older adults with asthma. (Source: Journal of the American Geriatrics Society)






Pulmonary Artery Enlargement Is Associated With Right Ventricular Dysfunction and Loss of Blood Volume in Small Pulmonary Vessels in Chronic Obstructive Pulmonary Disease [Pulmonary Arterial Hypertension]

Wed, 08 Apr 2015 00:00:00 +0100

Conclusions— The loss of blood volume in distal pulmonary vessels is associated with PA enlargement on computed tomography. Cardiac MRI detects early RV dysfunction and remodeling in nonsevere chronic obstructive pulmonary disease patients with a PA:A>1. Both RV dysfunction and PA enlargement are independently associated with reduced walk distance. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00608764. (Source: Circulation: Cardiovascular Imaging)



Discontinuous versus Continuous Weaning in Stroke Patients

Tue, 07 Apr 2015 15:48:37 +0100

Conclusions: To the best of our knowledge, this is the first clinical study to show that continuous weaning is significantly more effective compared to discontinuous weaning in mechanically ventilated stroke patients. We suppose that the reason for the superiority of continuous weaning using ASV as well as the bad performance of our patients in the 2 h T-piece test is caused by the patients' compliance. Compared to patients on surgical and medical ICUs, neurological patients more often suffer from reduced vigilance, lack of adverse-effects reflexes, dysphagia, and cerebral dysfunction. Therefore, stroke patients may profit from a more gradual withdrawal of weaning.Cerebrovasc Dis 2015;39:269-277 (Source: Cerebrovascular Diseases)

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Synergistic regulation of PDE4B by PKA-C{beta} and p65 [Pharmacology]

Tue, 07 Apr 2015 00:00:00 +0100

Phosphodiesterase 4B (PDE4B) plays a key role in regulating inflammation. Roflumilast, a phosphodiesterase (PDE)4-selective inhibitor, has recently been approved for treating severe chronic obstructive pulmonary disease (COPD) patients with exacerbation. However, there is also clinical evidence suggesting the development of tachyphylaxis or tolerance on repeated dosing of roflumilast and the... (Source: Proceedings of the National Academy of Sciences)



Evaluation of Lung Cancer by Estimating Ferritin in Exhaled Breath Condensate

Tue, 07 Apr 2015 00:00:00 +0100

Conclusion The estimated ferritin level in EBC can serve as a non invasive and inexpensive marker for screening of lung cancer. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)



Total serum IgE level in COPD patients

Tue, 07 Apr 2015 00:00:00 +0100

Conclusions There was a high prevalence of elevated serum T-IgE in patients with COPD but without obvious atopy. Serum T-IgE levels were found to be associated with symptoms such as dyspnea and impairment of lung function. Recurrent exacerbation of COPD is believed to accelerate disease progression and impairment of pulmonary function. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)



The evolving role of MDCT in the assessment of patients with chronic obstructive pulmonary disease

Tue, 07 Apr 2015 00:00:00 +0100

The purpose of this article is to educate the reader in the value a radiologist can offer in the multidetector (MD) CT assessment of patients with chronic obstructive pulmonary disease (COPD). MDCT can identify patients in whom treatments such as lung volume reduction surgery or newer endobronchial therapies may be of benefit. We will also discuss important and under-recognized associated cardiorespiratory disease, which may be incidentally identified. (Source: Clinical Radiology)



Does the COPD assessment test (CAT TM ) questionnaire produce similar results when self- or interviewer administered?

Tue, 07 Apr 2015 00:00:00 +0100

Conclusions The mode of administration does not influence CAT scores or its psychometric properties. Hence, both modes of administration can be used in clinical practice depending on the physician judgment of patient’s capacity. (Source: Quality of Life Research)

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Mixed-Effects Model of Epithelial-Mesenchymal Transition Reveals Rewiring of Signaling Networks.

Tue, 07 Apr 2015 00:00:00 +0100

Authors: Desai P, Yang J, Tian B, Sun H, Kalita M, Ju H, Paulucci-Holthauzen A, Zhao Y, Brasier AR, Sadygov RG Abstract The type II Epithelial-Mesenchymal Transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system effects of EMT on signaling networks. Here, we use mixed effects modeling to develop a computational model of phospho-protein signaling data that compares human small airway epithelial cells (hSAECs) with their EMT-transformed counterparts across a series of perturbations with 8 ligands and 5 inhibitors, revealing previously uncharacterized changes in signaling in the EMT...



Effectiveness of Repeated Courses of Pulmonary Rehabilitation on Functional Exercise Capacity in Patients With COPD.

Tue, 07 Apr 2015 00:00:00 +0100

CONCLUSION: Two-thirds of patients with COPD undergoing repeat PR experienced significant improvement in exercise capacity. Offering PR to patients with COPD on an as-needed basis appears to be beneficial even after a prolonged period of time between the interventions. PMID: 25856732 [PubMed - as supplied by publisher] (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)



QVA149 (indacaterol/glycopyrronium) for the treatment of chronic obstructive pulmonary disease

Mon, 06 Apr 2015 05:21:22 +0100

Expert Opinion on Pharmacotherapy, Ahead of Print. (Source: Expert Opinion on Pharmacotherapy)



Dislodged Pacer Lead Causing Ventricular Tachycardia

Mon, 06 Apr 2015 00:00:00 +0100

A 68-year-old woman with history of congestive heart failure, chronic obstructive pulmonary disease, type II diabetes, and hypertension, presented to the Emergency Department with acute onset of shortness of breath. She had been discharged from the hospital 2 days prior after pacemaker placement for a tachycardia/bradycardia syndrome. She did well postoperatively, but stated the shortness of breath started 12 h prior to presentation and progressively worsened. She denied chest pain, cough, fevers, palpitations, or syncope. (Source: The Journal of Emergency Medicine)



Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model

Mon, 06 Apr 2015 00:00:00 +0100

This study provides first steps toward a well‐characterized model with defined functional methods for understanding dsRNA stimulated inflammatory responses in a physiologically relevant manner. 12334 In this study we explore the mechanistic responses of a primary human bronchial epithelial model, that recapitulates in vivo airway physiology, to poly(I:C), a synthetic analog of viral dsRNA. We demonstrate that our model recapitulates innate immune responses to poly(I:C) stimulation by establishing metrics to evaluate baseline functions, such as mucus production and epithelial cell alterations, as well as gene and cytokine expression. Our approach provides a strong foundation for better understanding virus‐stimulated inflammatory responses in a well‐characterized model. (Source: Physi...

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IL-17A is Elevated in End-stage COPD and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis.

Mon, 06 Apr 2015 00:00:00 +0100

CONCLUSION: IL-17A in the peripheral lung of patients with severe-very severe COPD may contribute to disease progression and development of lymphoid follicles via activation of CXCL12. PMID: 25844618 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)



Chronic disease prevalence in women and air pollution - A 30-year longitudinal cohort study.

Mon, 06 Apr 2015 00:00:00 +0100

CONCLUSIONS: This study estimated significant elevated prevalent rate ratios per unit increase in PM2.5 in nine of the ten chronic diseases studied. PMID: 25863281 [PubMed - as supplied by publisher] (Source: Environment International)



Determinants of peak VO2 in heart transplant recipients

Sun, 05 Apr 2015 17:59:08 +0100

Conclusion: The determinants of the peak VO2 in heart transplant recipients were: receptor sex, age, Body Mass Index, heart rate reserve and left atrium diameter. Heart rate reserve was the unique variable positively associated with peak VO2. This data suggest the importance of the sympathetic reinnervation in peak VO2 in heart transplant recipients. Objetivo: Estabelecer os determinantes do VO2 pico em transplantados de coração. Métodos: Avaliação do paciente foi realizada em dois dias consecutivos. No primeiro dia, os pacientes realizaram a avaliação da variabilidade da frequência cardíaca seguida de um teste de esforço cardiopulmonar. No segundo dia, os pacientes realizaram ecocardiografia de repouso. Os transplantados foram elegíveis se estivessem em uma condição estável ...



Factors associated with the quality of life of Korean COPD patients as measured by the EQ-5D

Sat, 04 Apr 2015 15:26:43 +0100

Conclusions The EQ-5D score could be a useful instrument for evaluating the quality of life of COPD patients in Korea. In Korean COPD patients, the main determinants of EQ-5D scores include older age, female gender, lower household income, lower education level, severe airflow obstruction, and many comorbid diseases. (Source: Quality of Life Research)



Association of the biomarkers soluble ST2, galectin-3 and growth-differentiation factor-15 with heart failure and other non-cardiac diseases

Sat, 04 Apr 2015 00:00:00 +0100

Conclusion : Because increased plasma concentrations of sST2, galectin-3, and GDF-15 are not specific for a distinct disease group, the three biomarkers are not useful for diagnostic purposes. The results of our study are novel with respect to sST2, galectin-3 and GDF-15 as markers of inflammatory diseases and should encourage further studies. (Source: Clinica Chimica Acta)

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Comorbidity in chronic obstructive pulmonary disease

Sat, 04 Apr 2015 00:00:00 +0100

Publication date: Available online 4 April 2015 Source:Respiratory Investigation Author(s): Netsanet A. Negewo , Vanessa M. McDonald , Peter G. Gibson Patients with chronic obstructive pulmonary diseases (COPD) often experience comorbid conditions. The most common comorbidities that have been associated with COPD include cardiovascular diseases, lung cancer, metabolic disorder, osteoporosis, anxiety and depression, skeletal muscle dysfunction, cachexia, gastrointestinal diseases, and other respiratory conditions. Not only are comorbidities common but they also considerably influence disease prognosis and patients׳ health status, and are associated with poor clinical outcomes. However, perusal of literature indicates that little has been done so far to effectively assess, manage, and tre...



Association of the biomarkers soluble ST2, galectin-3 and growth-differentiation factor-15 with heart failure and other non-cardiac diseases.

Sat, 04 Apr 2015 00:00:00 +0100

CONCLUSION: Because increased plasma concentrations of sST2, galectin-3, and GDF-15 are not specific for a distinct disease group, the three biomarkers are not useful for diagnostic purposes. The results of our study are novel with respect to sST2, galectin-3 and GDF-15 as markers of inflammatory diseases and should encourage further studies. PMID: 25850080 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)



Should Age Be Part of Multidimensional Indices of Risk in Chronic Obstructive Pulmonary Disease?

Fri, 03 Apr 2015 12:42:59 +0100

Respiration 2015;89:274-275 (Source: Respiration)



Predicting Mortality and Exacerbations in Elders With COPDPredicting Mortality and Exacerbations in Elders With COPD

Fri, 03 Apr 2015 08:19:55 +0100

This study compares the validity of two measurement tools in the elderly COPD patient. Journal of the American Geriatrics Society (Source: Medscape Today Headlines)



Home Oxygen Raises Burn Risk for COPD Patients

Fri, 03 Apr 2015 07:00:00 +0100

Title: Home Oxygen Raises Burn Risk for COPD PatientsCategory: Health NewsCreated: 4/2/2015 12:00:00 AMLast Editorial Review: 4/3/2015 12:00:00 AM (Source: MedicineNet Lungs General)

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[Guidelines for outpatient pulmonary rehabilitation in Austria].

Fri, 03 Apr 2015 00:00:00 +0100

Authors: Vonbank K, Zwick RH, Strauss M, Lichtenschopf A, Puelacher C, Budnowski A, Possert G, Trinker M Abstract Pulmonary rehabilitation has become a standard of care for patients with chronic lung disease. It has been clearly demonstrated that pulmonary rehabilitation improves exercise capacity and quality of life in patients with chronic lung disease and reduces the number of hospital days and other measures of health-care utilization in patients with chronic obstructive pulmonary disease (COPD). This is an update of the guidelines in outpatient pulmonary rehabilitation in Austria, closely related to the official American Thoracic Society and European Respiratory Society Statement published in 2013.The guidelines represent standards of quality for requirements of structural and...



The global impact of non-communicable diseases on macro-economic productivity: a systematic review

Fri, 03 Apr 2015 00:00:00 +0100

Abstract Non-communicable diseases (NCDs) have large economic impact at multiple levels. To systematically review the literature investigating the economic impact of NCDs [including coronary heart disease (CHD), stroke, type 2 diabetes mellitus (DM), cancer (lung, colon, cervical and breast), chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD)] on macro-economic productivity. Systematic search, up to November 6th 2014, of medical databases (Medline, Embase and Google Scholar) without language restrictions. To identify additional publications, we searched the reference lists of retrieved studies and contacted authors in the field. Randomized controlled trials, cohort, case–control, cross-sectional, ecological studies and modelling studies carried out...



The impact of hypoxemia on serum total and free prostate-specific antigen levels in patients with chronic obstructive pulmonary disease

Fri, 03 Apr 2015 00:00:00 +0100

Abstract Prostate-specific antigen (PSA) is the most important biochemical marker in the diagnosis and follow-up of patients with prostate cancer. In recent years, a relationship between PSA levels and hypoxic conditions has been described. However, no study has investigated the PSA levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the impact of hypoxemia on serum total (tPSA) and free PSA (fPSA) levels in patients with COPD. Between January 2010 and January 2014, 95 male patients who hospitalized for acute exacerbations of COPD and 80 control subjects were enrolled in the study. Serum tPSA and fPSA levels and f/tPSA ratios were determined in all patients on the first day of hospitalization (exacerbation) and...



Alcohol dependence and physical comorbidity: Increased prevalence but reduced relevance of individual comorbidities for hospital-based mortality during a 12.5-year observation period in general hospital admissions in urban North-West England

Fri, 03 Apr 2015 00:00:00 +0100

Conclusion The excess of in-hospital deaths in general hospitals in individuals with AD is due to an increase of multiple physical comorbidities, even though individual diseases have an equal or even reduced impact on general hospital-based mortality in individuals with AD compared to controls. (Source: European Psychiatry)