Subscribe: MedWorm: Bronchiolitis
Added By: Feedage Forager Feedage Grade B rated
Language: English
bronchiolitis obliterans  bronchiolitis  care  children  disease  infants  lung  obliterans  respiratory  source  transplantation 
Rate this Feed
Rate this feedRate this feedRate this feedRate this feedRate this feed
Rate this feed 1 starRate this feed 2 starRate this feed 3 starRate this feed 4 starRate this feed 5 star

Comments (0)

Feed Details and Statistics Feed Statistics
Preview: MedWorm: Bronchiolitis

MedWorm: Bronchiolitis provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Bronchiolitis category.

Last Build Date: Mon, 21 Mar 2016 17:37:24 +0100


Macrolide Therapy for Prevention of Exacerbation in Individuals with Diffuse Aspiration Bronchiolitis

Mon, 21 Mar 2016 00:00:00 +0100

(Source: Journal of the American Geriatrics Society)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old

Thu, 17 Mar 2016 13:26:44 +0100

This Cochrane review was first published in 2005 and updated in 2007, 2012 and now 2015. Acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age. Chest physiotherapy is sometimes used to assist infants in the clearance of secretions in order to decrease ventilatory effort. (Source: Current Awareness Service for Health (CASH))

Induction Therapy in Lung Transplantation? A frustrating message of persisting uncertainty

Mon, 14 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)

Post-bronchiolitis Use of Asthma Medication: A Prospective 1-year Follow-up Study

Sat, 12 Mar 2016 19:07:26 +0100

Background: Our aim was to evaluate the association between viral findings during bronchiolitis and the use of asthma controller medication (primary outcome) and systemic corticosteroids (secondary outcome) during the first post-bronchiolitis year. Methods: We enrolled 408 children hospitalized for bronchiolitis at (Source: The Pediatric Infectious Disease Journal)

Oximetry Fails to Predict Future Bronchiolitis CareOximetry Fails to Predict Future Bronchiolitis Care

Sat, 12 Mar 2016 09:14:25 +0100

Pulse oximetry does not effectively predict which infants diagnosed with bronchiolitis will return for unscheduled medical care after an emergency department discharge. Medscape Medical News (Source: Medscape Allergy Headlines)

Cardiopulmonary and histological characterization of an acute rat lung injury model demonstrating safety of mesenchymal stromal cell infusion

Sat, 12 Mar 2016 00:00:00 +0100

Discussion Although our study did not show the infusion of MSCs to result in an improvement in lung function or rescue of damaged tissue this study does confirm the safety of MSC infusion into damaged lungs. (Source: Cytotherapy)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study

Sat, 12 Mar 2016 00:00:00 +0100

ConclusionsIn this cohort of young children in Norway, we found no association between vitamin D levels and the presence or severity of AE.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study.

Sat, 12 Mar 2016 00:00:00 +0100

CONCLUSIONS: In this cohort of young children in Norway, we found no association between vitamin D levels and the presence or severity of AE. This article is protected by copyright. All rights reserved. PMID: 26972308 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

The severity of acute bronchiolitis in infants was associated with quality of life nine months later

Fri, 11 Mar 2016 00:00:00 +0100

ConclusionThe severity of acute bronchiolitis in infants was associated with reduced QoL nine months later.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)

Diagnosis And Management Of Bronchiolitis Obliterans Syndrome Following Lung Or Hematopoietic Cell Transplantation.

Wed, 09 Mar 2016 08:02:02 +0100

Authors: Meyer KC PMID: 26950825 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)

Capnometry in children with bronchiolitis: a pathophysiological point of view

Mon, 07 Mar 2016 00:00:00 +0100

Bronchiolitis is the most common lower respiratory tract infection among infants and young children.1 (Source: Respiratory Medicine CME)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Pulse Oximetry: Is it Worthwhile in Infants With Bronchiolitis? (CME/CE)

Tue, 01 Mar 2016 12:35:00 +0100

(MedPage Today) -- Not an effective tool to predict subsequent return for care, researchers say (Source: MedPage Today Allergy)

Lung Transplantation: The State of the Airways.

Tue, 01 Mar 2016 00:00:00 +0100

Conclusions .- Postsurgical complications and infections of the airways have decreased because of better techniques and management. Acute cellular rejection of the airways can be distinguished from infection pathologically and on cultures. Separating small from large airways need not be an issue because both are risk factors for bronchiolitis obliterans. Grading of airway rejection needs to be standardized. Chronic lung allograft dysfunction consists of both bronchiolitis obliterans and restrictive allograft syndrome, neither of which can be treated very effectively at present. PMID: 26927718 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Ex Vivo Artifacts and Histopathologic Pitfalls in the Lung.

Tue, 01 Mar 2016 00:00:00 +0100

Conclusion .- Four patterns of pulmonary ex vivo artifacts are important to recognize in order to avoid morphologic misinterpretations. PMID: 26927715 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Bronchiolitis and Pulse Oximetry

Mon, 29 Feb 2016 00:00:00 +0100

In this issue of JAMA Pediatrics, Principi et al report the findings of their study titled, “Effect of Desaturations on Subsequent Medical Visits in Infants Discharged From the Emergency Department With Bronchiolitis.” The investigators prospectively enrolled infants with bronchiolitis deemed suitable for discharge and monitored them with continuous pulse oximetry at home for the first day. The essential element of this study is that the pulse oximeter had deactivated threshold alarms and did not display saturation values. The monitors, in addition to study diaries, were collected and analyzed, and the patients received follow-up calls at 72 hours. The results of this study call into question the assumptions of current practice around use of pulse oximetry for decision making in bronch...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Oxygen Desaturations After Discharge of Infants With Bronchiolitis

Mon, 29 Feb 2016 00:00:00 +0100

This cohort study examines whether there is a difference in the proportion of unscheduled medical visits following emergency department discharge in infants who have bronchiolitis with vs without oxygen desaturations. (Source: JAMA Pediatrics)

Monoallelic germline ATM mutation and organising pneumonia induced by radiation therapy to the breast

Mon, 29 Feb 2016 00:00:00 +0100

Organising pneumonia is defined by the presence of intra-alveolar buds consisting of inflammatory cells, fibroblasts and myofibroblasts, and loose connective tissue, often associated with bronchiolitis obliterans. Organising pneumonia may be cryptogenic (idiopathic) or associated with a variety of causes including, especially, infection, adverse reaction to drugs, connective tissue diseases [1] and radiation therapy to the breast [2, 3]. (Source: European Respiratory Journal)

Respiratory syncytial virus - more chimera than chimpanzee?

Sat, 27 Feb 2016 02:33:06 +0100

Authors: Thorburn K Abstract Respiratory syncytial virus (RSV) is the single most important virus causing acute respiratory tract infections and the most common viral respiratory cause of death in young children and especially in infants less than 1 year old throughout the world. RSV bronchiolitis usually occurs in predictable annual seasons/epidemics, varying by climatic and geographic region, that globally generate surges in hospitalizations/hospital admission rates which often strain health care capacity. Not all babies are born equal - those with comorbidity are at increased risk for severe RSV disease and death. PMID: 26906878 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)

Efficacy of noninvasive mechanical ventilation in prevention of intubation and reintubation in the pediatric intensive care unit

Fri, 26 Feb 2016 00:00:00 +0100

Conclusions Noninvasive mechanical ventilation effectively and reliably reduced endotracheal intubation in the treatment of respiratory failure due to different clinical situations. Our results suggest that NIV can play an important role in PICUs in helping to avoid intubation and prevent reintubation. Although there were serious underlying diseases in most of our patients, such as immunosuppression, 70% avoided intubation with use of NIV. (Source: Journal of Critical Care)

[Is it urgent to update the spanish clinical practice guidelines for acute bronchiolitis management?]

Fri, 26 Feb 2016 00:00:00 +0100

Authors: Martínez-Blanco B, Martinón-Torres F PMID: 26935760 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Mutually exclusive ERK Pathway Mutations are present in different stages of multifocal Pulmonary Langerhans Cell Histiocytosis supporting clonal nature of the disease

Thu, 25 Feb 2016 19:19:14 +0100

ConclusionThe presence of identical but mutually exclusive ERK pathway mutations in multifocal PLCH supports a neoplastic/clonal origin for this disease. Patient age and mutation type differed between cellular and fibrotic histology and may indicate a natural progression or a mutation‐specific pathogenicity.This article is protected by copyright. All rights reserved. (Source: Histopathology)

Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation

Thu, 25 Feb 2016 00:00:00 +0100

Abstract It is plausible that infections post‐hematopoietic SCT play a role in the pathogenesis of BOS. A prospective study for children with history, questionnaire, examination, PFTs, and blood counts at one, three, six, nine, 12, 18, and 24 months post‐SCT was conducted. Between September 2009 and September 2011 (n = 39), six developed BOS at 200 days (range 94–282), three patients had probable clinical respiratory infection, and all six had higher neutrophil count compared to non‐BOS patients (4.7 vs. 2.4 at three months and 6.3 vs. 2.9 at six months ×109/L, p = 0.03). Contribution of clinical and subclinical infection needs to be considered in the pathogenesis of BOS. (Source: Pediatric Transplantation)

Spectrum of Smoking-related Lung Diseases: Imaging Review and Update

Wed, 24 Feb 2016 08:11:14 +0100

There is increased awareness of smoking-related lung diseases other than lung cancer and chronic obstructive pulmonary disease. Concurrently, there is general acceptance that there is difficulty in establishing a specific diagnosis of smoking-related interstitial lung disease (ILD), as many patients may not undergo biopsy to facilitate a specific histopathologic diagnosis. Cases that do proceed to biopsy may demonstrate multiple abnormalities, and histologic overlap between different disease processes may confound the picture. This review outlines the key aspects of smoking-related lung disease, including entities secondary to smoking-related lung inflammation such as respiratory bronchiolitis-ILD, desquamative idiopathic pneumonia, and pulmonary Langerhans cell histiocytosis, as well as c...

Is capnometry helpful in children with bronchiolitis?

Wed, 24 Feb 2016 00:00:00 +0100

Acute bronchiolitis is the most frequent lower respiratory tract infection in infants. Only small subsets of patients develop severe disease resulting in hospitalization despite having no identifiable risk factors. There is still a debate as to the role of capnometry in assessing ventilation in children with acute respiratory distress, and bronchiolitis in particular. (Source: Respiratory Medicine CME)

Why walking by a main road is as bad for you as smoking

Tue, 23 Feb 2016 07:30:53 +0100

William Phin, six, from Whitley Bay, north of Newcastle, has obliterative bronchiolitis - which may be triggered by pollution. A lung transplant is the only cure. (Source: the Mail online | Health)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Revascularization of the graft in obliterative bronchiolitis after heterotopic tracheal transplantation

Tue, 23 Feb 2016 00:00:00 +0100

Abstract Obliterative bronchiolitis is the principal long‐term problem for lung transplant patients. One of the simplest and most reproducible animal models of obliterative bronchiolitis is heterotopic tracheal transplantation in subcutaneous tissue, where the graft is not primarily vascularized. We demonstrate here the rapid graft revascularization and the kinetics of expression of its angiogenic and lymphatic factors. We performed iso‐ and allotracheal transplantations harvested on day 0–21. The number of functional blood vessels, quantified after intravenous biotinylated dextran administration, increased from D0 (0 for both iso‐ and allografts) to D21 (44 ± 8 vessels/mm2 in isografts and 22 ± 3 in allografts, P < 0.001 for both vs. D0). VEGF mRNA expression assessed ...

Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis

Mon, 22 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)

Latest options for treatment of bronchiolitis in infants.

Mon, 22 Feb 2016 00:00:00 +0100

Authors: Vandini S, Faldella G, Lanari M Abstract Bronchiolitis is the most frequent pathology associated with lower respiratory tract infection in newborns and young infants. The treatment of bronchiolitis is essentially supportive therapy for respiratory distress, hypoxia and dehydration. To date, no specific antiviral drug is used on a routine basis for the treatment of RSV infections. Currently, the only antiviral drug approved for the infection is ribavirin; however, its use is limited due to adverse side effects and the risks it poses to healthcare providers. Moreover, several drugs have been routinely administered for years in infants with acute RSV bronchiolitis, even if their efficacy is often not confirmed by clinical evidence, and studies on emerging antiviral drugs are ...

Current views and advances on Paediatric Virology: An update for paediatric trainees.

Sat, 20 Feb 2016 10:15:03 +0100

Authors: Mammas IN, Greenough A, Theodoridou M, Kramvis A, Christaki I, Koutsaftiki C, Koutsaki M, Portaliou DM, Kostagianni G, Panagopoulou P, Sourvinos G, Spandidos DA Abstract Paediatric Virology is a bold new scientific field, which combines Paediatrics with Virology, Epidemiology, Molecular Medicine, Evidence-based Medicine, Clinical Governance, Quality Improvement, Pharmacology and Immunology. The Workshop on Paediatric Virology, which took place on Saturday October 10, 2015 in Athens, Greece, provided an overview of recent views and advances on viral infections occurring in neonates and children. It was included in the official programme of the 20th World Congress on Advances in Oncology and the 18th International Symposium on Molecular Medicine, which attracted over 500 del...

Plasma Osteopontin Is a Biomarker Specifically Associated with Bronchiolitis Obliterans Syndrome after HCT

Fri, 19 Feb 2016 10:35:13 +0100

Bronchiolitis obliterans syndrome (BOS) is a rare complication after allogeneic hematopoietic cell transplant (HCT) and confers high mortality. BOS is difficult to diagnosis and a plasma biomarker specific for this form of chronic graft-vs.-host disease (cGVHD) would be invaluable. Osteopontin is produced by alternative alveolar macrophages both after radiation, chemotherapy, and may be up-regulated during remodeling and fibrotic pulmonary injury. We hypothesized that osteopontin would be elevated in patients with BOS after HCT if this alternative activation pathway of alveolar macrophages causes BOS after HCT. (Source: Biology of Blood and Marrow Transplantation)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Prenatal Tobacco Smoke Exposure and Bronchiolitis in InfantsPrenatal Tobacco Smoke Exposure and Bronchiolitis in Infants

Fri, 19 Feb 2016 05:09:01 +0100

A new study examines the association between tobacco smoke exposure during pregnancy and the risk for severe bronchiolitis in infants during the first year of life. Respiratory Research (Source: Medscape Allergy Headlines)

Virus Type and Genomic Load in Acute Bronchiolitis: Severity and Treatment Response With Inhaled Adrenaline

Fri, 19 Feb 2016 00:00:00 +0100

Discussion. In infants hospitalized with acute bronchiolitis, disease severity was not associated with specific viruses or the total number of viruses detected. A high RSV genomic load was associated with more-severe disease. Clinical Trials Registration. NCT00817466 and EudraCT 2009-012667-34. (Source: The Journal of Infectious Diseases)

Induction Therapy for Lung Transplantation in COPD: Analysis of the UNOS Registry.

Thu, 18 Feb 2016 02:56:02 +0100

Authors: Duffy JS, Tumin D, Pope-Harman A, Whitson BA, Higgins RS, Hayes D Abstract Although studies demonstrate that induction therapy improves outcomes after lung transplantation, its influence on survival in patients with chronic obstructive pulmonary disease (COPD) is not clear. The United Network for Organ Sharing database was queried to obtain data regarding adult patients with COPD receiving lung transplant between May 2005 and June 2014. Therapies evaluated include anti-thymocyte globulin, anti-lymphocyte globulin, thymoglobulin, basiliximab, and alemtuzumab. Data were categorized based on receiving induction (INDUCED) and no induction (NONE). Kaplan-Meier plots, Cox proportional hazards models of patient survival, and competing-risks regression models for secondary endpoin...

Trends in respiratory syncytial virus bronchiolitis hospitalizations in children less than 1 year: 2004-2012.

Thu, 18 Feb 2016 02:49:02 +0100

Conclusions RSV bronchiolitis is a leading cause of hospitalizations for infants under 1 year and has not shown incidence reduction over a 9 year period. Risk factors increase the in-hospital mortality risk and it is higher if the hospitalization cause is RSV bronchiolitis than any other reason. PMID: 26709735 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)

Evidence of Respiratory Syncytial Virus Spread by Aerosol: Time to Revisit Infection Control Strategies.

Thu, 18 Feb 2016 00:00:00 +0100

CONCLUSIONS: Many of the aerosolized particles, containing RSV, generated by infants with bronchiolitis were sufficiently small to remain airborne for a significant length of time and small enough to be inhaled and deposited throughout the respiratory tract. It is likely that this leads to spread of infection to others with dissemination of infection throughout the respiratory tract. PMID: 26890617 [PubMed - as supplied by publisher] (Source: Respiratory Care)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Cytokine responses in primary and secondary respiratory syncytial virus infections.

Tue, 16 Feb 2016 00:00:00 +0100

CONCLUSIONS: The very high levels of IL-8 and IL-6 response characteristic of the primary RSV infection was not observed in secondary RSV +ve infections and this did not appear to be due to a global reduction in cytokine production.Pediatric Research (2016); doi:10.1038/pr.2016.29. PMID: 26882371 [PubMed - as supplied by publisher] (Source: Pediatric Research)

Home oxygen therapy for infants and young children with acute bronchiolitis and other lower respiratory tract infections: the HiTHOx program.

Sun, 14 Feb 2016 19:09:04 +0100

CONCLUSIONS: The HiTHOx program provides an alternative model of care for infants and young children with acute LRTI. Implementation of models of care similar to that of the HiTHOx program in other pediatric health services may have the potential to create additional bed capacity, at the time of year when it is most needed. PMID: 24083944 [PubMed - indexed for MEDLINE] (Source: Issues in Comprehensive Pediatric Nursing)

Reduced Expression of HLA-DR on Monocytes During Severe Respiratory Syncytial Virus Infections

Sun, 14 Feb 2016 18:34:57 +0100

Conclusions: Phenotyping subpopulations of monocytes combined with in vitro responsiveness reveals significant differences between nonsevere and severe RSV infections. Reduced HLA-DR expression and impaired IL-10 production in vitro during severe RSV infections indicate that an imbalanced innate immune response may play an important role in disease severity. (Source: The Pediatric Infectious Disease Journal)

Population-based Analysis of Bronchiolitis Epidemiology in Valencia, Spain

Sun, 14 Feb 2016 18:34:56 +0100

Background: There is a lack of European epidemiologic population-based studies on bronchiolitis and respiratory syncytial virus (RSV) bronchiolitis including both hospitalizations and primary care attendance. Methods: A retrospective cohort of all children born between 2009 and 2012 was followed from birth to 2 years of age using population and health databases. We searched for global bronchiolitis (International Classification of Diseases, 9th revision, Clinical Modification codes 466.1, 466.11 and 466.19) and RSV bronchiolitis (code 466.11 and code 466.19 with positive RSV test) in the first appearance either in primary care or in hospitalization databases. A preterm subcohort (International Classification of Diseases, 9th revision, Clinical Modification codes 765) was also analyzed. R...

The Impact of Caloric Intake on Infants Receiving High Flow High Humidity Nasal Cannula Oxygen Therapy for Bronchiolitis

Fri, 12 Feb 2016 00:00:00 +0100


MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Impact of Effective Physician Communication and Parental Understanding of Care on Parental Satisfaction with Hospitalization for Bronchiolitis

Fri, 12 Feb 2016 00:00:00 +0100


MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Spontaneous Pneumothorax With Subcutaneous Emphysema: A Rare Complication of Respiratory Syncytial Virus Infection.

Thu, 11 Feb 2016 08:15:03 +0100

We report a case of a 21-month-old female that developed a spontaneous pneumothorax (PNO) with subcutaneous emphysema (SE) late in the course of RSV acute bronchiolitis. Additional investigation ruled out any underlying disease predisposing to spontaneous PNO. Physicians, especially those who work with small children, must be aware of this uncommon complication of bronchiolitis that may appear late in the course of the disease despite an initial clinical improvement. PMID: 26858803 [PubMed] (Source: Clin Med Res)

Children Hospitalized with Rhinovirus Bronchiolitis Have Asthma-Like Characteristics

Thu, 11 Feb 2016 00:00:00 +0100

Children with bronchiolitis often are considered a homogeneous group. However, in a multicenter, prospective study of 2207 young children hospitalized for bronchiolitis, we found that children with respiratory syncytial virus detected differ from those with rhinovirus detected; the latter patients resemble older children with asthma, including more frequent treatment with corticosteroids. (Source: The Journal of Pediatrics)

Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis

Wed, 10 Feb 2016 10:19:20 +0100

Summary The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneumococci. In patients with viral bronchiolitis who did not receive antibiotics, pneumococcal load decreased from time of admission to discharge (n = 35, cycle threshold 23 vs. 25, P = 0.0017) and from discharge to follow‐up (n = 22, cycle threshold 25 vs. 40, P = 0.003). We conclude that viral respiratory infection is negatively associated with pneumococcal colonization of the upper airways. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Ped...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

[Small airway diseases and immune deficiency].

Tue, 09 Feb 2016 15:24:02 +0100

CONCLUSION: Small airway diseases have different clinical expression and pathophysiology across various causes of immune deficiency. A better understanding of small airways disease pathogenesis in these settings may lead to the development of novel targeted therapies. PMID: 26854188 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)

Risk Factor and Clinical Outcome of Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation.

Mon, 08 Feb 2016 11:54:04 +0100

CONCLUSION: Peripheral blood as a stem cell source is a risk factor for the development of BOS. A decreased pretransplant FEV₁/FVC and shorter duration of time from transplantation to diagnosis of BOS are poor prognostic factors for BOS. PMID: 26847288 [PubMed - in process] (Source: Yonsei Medical Journal)

A rare aspect of Crohn's disease: Pulmonary involvement in a child

Mon, 08 Feb 2016 00:00:00 +0100

Ebru Atike Ongun, Reha Artan, Aysen Bingol, Oguz DursunIndian Journal of Critical Care Medicine 2016 20(2):114-116Crohn's disease (CD), known as the disease of gastrointestinal system, is a granulamatous systemic disorder with extraintestinal manifestations including the respiratory system. The resemblance in the embriological origins and the immunities of both organ systems' mucosae, also the circulating immune complexes and the autoantibodies are accepted as contributing factors. The shift of inflammation may become prominent when the colon is removed after colectomy and independent of the bowel disease activity; pulmonary involvement may be exarbecated. In the pediatric population, CD associated pulmonary involvement is very rare, mainly in the form of subclinical ...

Surfactant Therapy for Bronchiolitis in Critically Ill Infants

Sun, 07 Feb 2016 04:06:09 +0100

No abstract available (Source: Clinical Nurse Specialist)

Hepatocyte growth factor enhances the inflammation-alleviating effect of umbilical cord–derived mesenchymal stromal cells in a bronchiolitis obliterans model

Fri, 05 Feb 2016 00:00:00 +0100

Conclusion Treatment of BO with HGF gene modified MSCs results in reduction of local inflammation and promotion in recovery of allograft trachea histopathology. These findings might provide an effective therapeutic strategy for BO. (Source: Cytotherapy)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Assessing Structural Quality Elements of Pediatric Emergency Care

Mon, 01 Feb 2016 06:00:00 +0100

Conclusions: Presence of necessary pediatric emergency equipment is better in the surveyed hospitals than in prior reports. Most responding hospitals have important protocol/procedures in place. These data may provide benchmarks for optimal care. (Source: Pediatric Emergency Care)

Pediatric Care Provided at Urgent Care Centers in the United States: Compliance With Recommendations for Emergency Preparedness

Mon, 01 Feb 2016 06:00:00 +0100

Conclusions: Areas for improvement in urgent care center preparedness were identified, such as increasing the availability of essential medications and equipment, establishing transfer and transport agreements with local hospitals and community EMS, and ensuring a structured quality improvement program. (Source: Pediatric Emergency Care)

Update on flavoring-induced lung disease

Mon, 01 Feb 2016 04:04:30 +0100

This article reviews recent flavoring exposures and data on the pathogenesis, clinical characteristics, and surveillance of flavoring-induced lung disease. Recent findings: Diacetyl and 2,3-pentanedione exposures have occurred in food production facilities that make cookies, cereal, chocolate, and coffee. Airborne levels often exceed proposed occupational exposure limits. Cases of biopsy-proven bronchiolitis obliterans in heavy popcorn consumers have also been reported. New data demonstrate the presence of diacetyl and 2,3-pentanedione in flavored nicotine liquids used in electronic nicotine delivery systems. Summary: Diacetyl substitutes cause similar peri-bronchiolar fibrotic lesions in animal studies. Their use may continue to place workers at risk for flavoring-induced lung disease, ...

The Impact of Alemtuzumab and Basiliximab Induction on Patient Survival and Time to Bronchiolitis Obliterans Syndrome in Double Lung Transplantation Recipients

Mon, 01 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)

Maybe there is no such thing as bronchiolitis.

Mon, 01 Feb 2016 00:00:00 +0100

Authors: Kuzik BA PMID: 26833735 [PubMed - as supplied by publisher] (Source: cmaj)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Proteomic characterization reveals that MMP‐3 correlates with bronchiolitis obliterans syndrome following allogeneic hematopoietic cell and lung transplantation

Mon, 01 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)

Clinical features of usual interstitial pneumonia with anti‐neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis

Mon, 01 Feb 2016 00:00:00 +0100

ConclusionANCA/UIP may be distinguishable from IPF/UIP with a combination of HRCT findings of increased attenuation around honeycombing and cysts and some of the characteristic pathological findings. In contrast to IPF/UIP, immunosuppressive treatment could be a therapeutic option for ANCA/UIP. (Source: Respirology)

Interstitial lung disease in a female worker sensitized to epoxy resins: a case report submitted for discussion.

Sat, 30 Jan 2016 13:49:02 +0100

Authors: Calisti R Abstract Epoxy resins are well known agents in respiratory medicine for their potential to induce bronchial asthma; the possibility of these agents causing respiratory diseases such as asthma, bronchitis, bronchiolitis obliterans with organizing pneumonia (BOOP) and similar lung diseases, has been poorly investigated.[...]. PMID: 26822248 [PubMed - in process] (Source: Medicina del Lavoro)

[Respiratory syncytial virus (RSV) infections in the pediatric teaching hospital Charles de Gaulle of Ouagadougou, Burkina Faso].

Sat, 30 Jan 2016 06:08:02 +0100

This study confirms the important place of the viruses which are detected in 70% of the cases. The PCR multiplex, certainly expensive but effective and successful, deserves to be used in our developing countries to avoid the irrational prescription of antibiotic. PMID: 26821370 [PubMed - as supplied by publisher] (Source: Bulletin de la Societe de Pathologie Exotique)

Obliterative Bronchiolitis

Fri, 29 Jan 2016 13:05:25 +0100

Abstract: Obliterative bronchiolitis (OB) is a clinical syndrome marked by progressive dyspnea and cough with the absence of parenchymal lung disease on radiographic studies. Pulmonary function testing reveals an obstructive ventilatory defect that is typically not reversed by inhaled bronchodilator. Transbronchial biopsies are insufficiently sensitive to achieve diagnosis, and in most cases, clinical, physiological, and radiological data obviate the need for the increased risk associated with open lung biopsy. This diagnosis has been documented in a variety of exposures, including fumes from flavoring plants, smoke from burn pits, and environmental sulfur gas. Among lung transplant recipients, “bronchiolitis obliterans syndrome,” a disorder with clinical and histopathological similari...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Bronchiolitis – Rationale for current recommendations for diagnosis and management

Fri, 29 Jan 2016 00:00:00 +0100

Publication date: Available online 16 January 2016 Source:Pediatric Infectious Disease Author(s): Sumitha Nayak Bronchiolitis is a lower respiratory infection caused commonly by RSV in the initial 2 years of life. It is responsible for a large number of hospitalizations. Pulse oximetry plays an important role in monitoring the progression of disease. Supplemental oxygen administration is not recommended at saturation levels above 90%. (Source: Pediatric Infectious Disease)

Phenytoin induced Steven–Johnson syndrome and bronchiolitis obliterans – case report and review of literature

Mon, 25 Jan 2016 00:00:00 +0100

We report a case of phenytoin induced SJS/TEN followed by severe bronchiolitis obliterans in an adult patient. The presentation, pathophysiology and management of SJS/TEN related bronchiolitis obliterans is also reviewed. (Source: Respiratory Medicine Case Reports)

Rett Syndrome: An Autoimmune Disease?

Sat, 23 Jan 2016 00:00:00 +0100

Publication date: Available online 22 January 2016 Source:Autoimmunity Reviews Author(s): Claudio De Felice, Silvia Leoncini, Cinzia Signorini, Alessio Cortelazzo, Paolo Rovero, Thierry Durand, Lucia Ciccoli, Anna Maria Papini, Joussef Hayek Rett syndrome (RTT) is a devastating neurodevelopmental disease, previously included into the autistic spectrum disorders, affecting almost exclusively females (frequency 1:10,000). RTT leads to intellective deficit, purposeful hands use loss and late major motor impairment besides featuring breathing disorders, epilepsy and increased risk of sudden death. The condition is caused in up to 95% of the cases by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Our group has shown a number of previously unrecognized features, ...

Human Metapneumovirus Infection in Children with a History of Prematurity – A Condition Worth More Attention

Thu, 21 Jan 2016 00:00:00 +0100

The rapid advance of molecular technologies in the past few decades has led to the discovery of several previously unknown viral pathogens of common childhood respiratory illness. Human metapneumovirus (hMPV), discovered in 2001,1 is one example. Clinical presentations of hMPV infection include bronchiolitis, pneumonia, croup, and asthmatic exacerbations,2,3 which are indistinguishable from those caused by other respiratory viruses such as respiratory syncytial virus (RSV). (Source: Pediatrics and Neonatology)

Air-leak Syndrome by Pleuroparenchymal Fibroelastosis after Bone Marrow Transplantation.

Wed, 20 Jan 2016 19:05:02 +0100

Conclusion ALS-PPFE is an extremely late-onset noninfectious pulmonary complication of allo-BMT. This complication is progressive, resistant to immunosuppressive treatment and has a poor prognosis. No association was found between PPFE and GVHD. PMID: 26781007 [PubMed - in process] (Source: Internal Medicine)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Bronchiolitis obliterans – pleading for a pragmatic approach

Wed, 20 Jan 2016 00:00:00 +0100

(Source: Biology of Blood and Marrow Transplantation)

Highlights from this issue

Wed, 20 Jan 2016 00:00:00 +0100

Admissions with bronchiolitis Admissions with bronchiolitis during the ‘season’ are a considerable burden to the overall paediatric health care resource. Green and colleagues report on the changes in hospital admission rates over the last 50 years. This is by analysis of multiple different recording systems including Hospital Inpatient Enquiry (1968–85), Hospital Episode Statistics (1989–2011), Oxford Record Linkage Study (1963–2011) and Paediatric Intensive Care Audit Network (2003–12). The data shows a seven fold increase since bronchiolitis was given a separate discharge code in 1979 from 6.6 to 46.1 episodes per 1000 infants aged less than 1, whereas admissions to paediatric intensive care units (PICU) rose only a little (1.3 to 1.6 infants per 1000 ...

Stemming the tide of hospital admissions for bronchiolitis

Wed, 20 Jan 2016 00:00:00 +0100

Bronchiolitis is a source of unique fascination for health services researchers. Partly this is due to its ubiquity, as the single most common cause of children being admitted to hospital and to paediatric intensive care units in the UK and USA. Partly it is the fact that, for the overwhelming majority of affected infants, treatment is supportive, despite the historical procession of postulated treatments and vaccines which so far have had no impact on prevention or outcome. Thus, health professionals and health services researchers have concentrated their efforts on reducing unnecessary medical intervention such as use of antibiotics, bronchodilators or chest X-rays. Green et al contribute to the literature on healthcare utilisation in bronchiolitis with their retrospective analysis of ho...

Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma

Wed, 20 Jan 2016 00:00:00 +0100

Conclusions Hospital admissions for infants with bronchiolitis have increased substantially in recent years. However, cases requiring intensive care have changed little since 2004. (Source: Archives of Disease in Childhood)

Recent advances in paediatric respiratory medicine

Wed, 20 Jan 2016 00:00:00 +0100

This review highlights important advances in paediatric respiratory medicine since 2014, excluding cystic fibrosis. It focuses mainly on the more common conditions, bronchopulmonary dysplasia, bronchiolitis and preschool wheezing, asthma, pneumonia and sleep, and highlights some of the rarer conditions such as primary ciliary dyskinesia and interstitial lung disease (ILD). (Source: Archives of Disease in Childhood)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Phenytoin induced Steven-Johnson syndrome and bronchiolitis obliterans-case report and review of literature

Wed, 20 Jan 2016 00:00:00 +0100

We report a case of phenytoin induced SJS/TEN followed by severe bronchiolitis obliterans in an adult patient. The presentation, pathophysiology and management of SJS/TEN related bronchiolitis obliterans is also reviewed. (Source: Respiratory Medicine Case Reports)

Highlights from this issue

Wed, 20 Jan 2016 00:00:00 +0100

I've written here before about how each issue ranges from the sublime to the ridiculous. This is a misuse of the saying—certainly at the ridiculous end—but the phrase captures well for me the range of reading experience you'll get in this issue. Take, for instance, the paper by Lydia Forestier-Zhang and Nick Bishop on understanding basic bone mechanics (see page 2). When these authors approached me to write this, I wondered if it would be of relevance to readers, and was persuaded by them that it was. I'm pleased that they did so; I've sat in many safeguarding meetings explaining why I'm concerned that a child's bone has fractured, and this gives me a more sound backing to, as the authors put it, the reasons why some bones break and others don't, given the same trauma and force...

NICE clinical guideline: bronchiolitis in children

Wed, 20 Jan 2016 00:00:00 +0100

Information about current guideline Bronchiolitis is a lower respiratory tract infection commonly seen in children less than 1 year of age.1 2 Predominantly occurring in winter months, bronchiolitis is in the majority managed in the primary care setting, but it contributes to a significant proportion of the admissions to paediatric wards with a small number requiring intensive care. The National Institute for Health and Care Excellence (NICE) guideline ‘Bronchiolitis in Children’ was published in June 2015.1 It aims to direct management of bronchiolitis in both primary and secondary care. The guideline was developed by the National Collaborating Centre for Women's and Children's Health. Previous guideline This is the first NICE guideline that covers bronchiolitis. The Scot...

Bronchiolitis Obliterans: Pleading for a Pragmatic Approach

Wed, 20 Jan 2016 00:00:00 +0100

Bronchiolitis obliterans (BO) presents 1 of the most challenging organ manifestations of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) because of its associated morbidity and mortality [1]. Moreover, progress in treatment has been hampered by the fact that with an incidence of 2% to 10% after alloHSCT, BO in the context of chronic GVHD is an orphan disease with literally no approved treatment after steroid failure. Further, only a few clinical trials evaluating therapeutic strategies for chronic GVHD have focused on pulmonary manifestations [1]. (Source: Biology of Blood and Marrow Transplantation)

Bronchiolitis obliterans syndrome

Tue, 19 Jan 2016 00:00:00 +0100

Publication date: August 2003 Source:Chest Surgery Clinics of North America, Volume 13, Issue 3 Author(s): Paul A Corris (Source: Chest Surgery Clinics of North America)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Respiratory Syncytial Virus: A Byzantine Pathogen

Mon, 18 Jan 2016 00:00:00 +0100

Respiratory syncytial virus (RSV) causes more disease among infants and young children than most viruses, yet understanding of the pathogenesis of many aspects of RSV disease remain limited.1,2 The consequences of RSV infection differ depending on the immune and inflammatory responses of the host, pulmonary and cardiac anatomic factors of the host, and poorly understood characteristics of the virus.2 Understanding remains limited as to why most primary RSV infections are confined to the upper respiratory tract whereas in some children infection progresses to bronchiolitis and pneumonia. (Source: The Journal of Pediatrics)

Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation.

Sat, 16 Jan 2016 23:16:01 +0100

Authors: Yu J Abstract Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood. Further studies f...

BRONCHIOLITIS- Rationale for Current recommendations for diagnosis and management

Sat, 16 Jan 2016 00:00:00 +0100

Publication date: Available online 16 January 2016 Source:Pediatric Infectious Disease Author(s): SUMITHA NAYAK (Source: Pediatric Infectious Disease)

Prevalence of Human metapneumovirus infection among patients with influenza-like illness: Report from a Tertiary Care Centre, Southern India

Fri, 15 Jan 2016 00:00:00 +0100

Conclusion: This study shows that HMPV infection is more common in adults than in children. Sequence homology suggests the circulation of closely related HMPV strains within the country. (Source: Indian Journal of Medical Microbiology)

miR-144 is Unlikely to Play a Role in Bronchiolitis Obliterans Syndrome

Thu, 14 Jan 2016 00:00:00 +0100

Letter to the Editor (Source: The Journal of Heart and Lung Transplantation)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome

Thu, 14 Jan 2016 00:00:00 +0100

In this study, the authors propose “a critical role for miR-144 for the pathogenesis of lung fibrosis leading to BOS [bronchiolitis obliterans syndrome] after human lung transplantation” after transfecting this microRNA (miRNA) into lung fibroblasts and demonstrating regulatory behavior. (Source: The Journal of Heart and Lung Transplantation)

Pre‐birth cohort study of atopic dermatitis and severe bronchiolitis during infancy

Wed, 13 Jan 2016 00:00:00 +0100

ConclusionsAD is significantly associated with severe bronchiolitis in infancy. The mechanism of the AD‐bronchiolitis association is unclear and merits further study; this research may shed light on the pathogenesis of asthma.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)

Absence of Bordetella pertussis Among Infants Hospitalized for Bronchiolitis in Finland, 2008–2010

Tue, 12 Jan 2016 20:15:40 +0100

In 169 Finnish infants hospitalized for bronchiolitis at age (Source: The Pediatric Infectious Disease Journal)

An Interesting Case of Bilateral Lung Consolidation.

Tue, 12 Jan 2016 19:40:03 +0100

Authors: Pawar S, Sharma A, Ragesh R, Nischal N, Jha S, Das CJ, Sharma MC, Sharma SK Abstract Organising pneumonia is a histopathological entity characterised by intra-alveolar buds of granulation tissue, intermixed myofibroblasts and connective tissue. Cryptogenic organising pneumonia (COP) is characterised by this particular histopathological pattern, along with typical clinical and imaging features, when no other underlying aetiology is found. COP (previously known as bronchiolitis obliterans organising pneumonia [BOOP]) is one of the rare variants of interstitial pneumonias. This condition is characterised by a rapid clinical and radiological improvement with steroid treatment. Here we are reporting a case of COP in adult female with discussion on approach and basic pathophysio...

Why your wheezing baby may need TLC, not medication

Tue, 12 Jan 2016 14:00:45 +0100

Follow me at @drClaire When a baby is sick with fever, cough, and a wheeze, it’s natural to think that what they need is medication — like an antibiotic, or one of the medications used to treat wheezing in children with asthma (such as albuterol). But it turns out that if a condition called bronchiolitis is the culprit, the best treatment is no treatment. Bronchiolitis is a bad cold (caused by various viruses) that settles into the lungs. When it does, it leads to fever, lots of congestion, cough, and noisy or wheezy breathing. It’s incredibly common. In fact, one in five babies under 12 months ends up at the doctor’s office for bronchiolitis — and 2% to 3% end up hospitalized. It can be quite serious, especially when it’s caused by a particular virus called respiratory syncyti...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Your NEJM Group Today: Viral Bronchiolitis Clinical Pearls, Medical Marijuana & Painful Neuropathy, Detroit Internal Medicine Leadership Opportunity (FREE)

Tue, 12 Jan 2016 00:00:00 +0100

By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:Now@NEJM Blog: Clinical Pearls: Is the course of viral bronchiolitis or … (Source: Physician's First Watch current issue)

Hypertonic Saline for BronchiolitisHypertonic Saline for Bronchiolitis

Thu, 07 Jan 2016 17:00:00 +0100

Recent studies agree that to do less is to do more for the recovery of the child with bronchiolitis. Archives of Disease in Childhood (Source: Medscape Critical Care Headlines)

Viral Bronchiolitis in Children

Wed, 06 Jan 2016 22:00:08 +0100

New England Journal of Medicine, Volume 374, Issue 1, Page 62-72, January 2016. (Source: New England Journal of Medicine)

Gestational Age, Birthweight for Gestational Age, and Childhood Hospitalisations for Asthma and Other Wheezing Disorders

Wed, 06 Jan 2016 00:00:00 +0100

ConclusionThe association of preterm birth with childhood wheezing could be biologically mediated. We cannot rule out an association for early term births. (Source: Paediatric and Perinatal Epidemiology)

Increased Myeloid Cell Hypoxia-Inducible Factor-1 Delays Obliterative Airway Disease in the Mouse

Wed, 06 Jan 2016 00:00:00 +0100

Obliterative bronchiolitis after lung transplantation is characterized by chronic airway inflammation leading to the obliteration of small airways. Hypoxia inducible factor-1 (HIF-1) is a master regulator of cellular responses to hypoxia and inflammation. The Von Hippel-Lindau protein (pVHL) drives the degradation of oxygen-sensitive subunit HIF-1α that controls the activity of HIF-1. We investigated the effect of myeloid cell-targeted gene deletion of HIF-1α or its negative regulator pVHL in the recipients of tracheal allografts on the development of obliterative airway disease (OAD), a mouse model for obliterative bronchiolitis after lung transplantation. (Source: The Journal of Heart and Lung Transplantation)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Network Analysis of Lung Transcriptomics Reveals a Distinct B Cell Signature in Emphysema.

Wed, 06 Jan 2016 00:00:00 +0100

CONCLUSIONS: Our study identifies enrichment in B cell related genes in COPD patients with emphysema that is absent in bronchiolitis. These observations contribute to a better understanding of COPD pathobiology and may open new therapeutic opportunities for COPD patients. PMID: 26735770 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Extracorporeal photopheresis as a new supportive therapy for bronchiolitis obliterans syndrome after allogeneic stem cell transplantation

Mon, 04 Jan 2016 00:00:00 +0100

Authors: C Del Fante, T Galasso, P Bernasconi, L Scudeller, F Ripamonti, C Perotti & F Meloni (Source: Bone Marrow Transplantation)

A Multicenter Collaborative to Reduce Unnecessary Care in Inpatient Bronchiolitis

Mon, 04 Jan 2016 00:00:00 +0100

CONCLUSIONS: A voluntary collaborative was effective in reducing unnecessary care among a cohort of primarily community hospitals. Such a strategy may be generalizable to the settings where the majority of children are hospitalized in the United States. (Source: PEDIATRICS)

Pediatric Asthma and Viral Infection.

Mon, 04 Jan 2016 00:00:00 +0100

Authors: Garcia-Garcia ML, Calvo Rey C, Del Rosal Rabes T Abstract Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are the most importance risk factors for the onset of wheezing in infants and small children. Bronchiolitis is the most common acute respiratory infection in children under 1year of age, and the most common cause of hospitalization in this age group. RSV accounts for approximately 70% of all these cases, followed by rhinovirus, adenovirus, metapneumovirus and bocavirus. The association between bronchiolitis caused by RSV and the development of recurrent wheezing and/or asthma was first described more than 40years ago, but it is still unclear whether bronchiolitis causes chronic respiratory symptoms, or if it is a marker for ...