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MedWorm: Asthma



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Asthma category.



Last Build Date: Tue, 22 Mar 2016 08:27:54 +0100

 



Update on Immunotherapy for the Treatment of AsthmaUpdate on Immunotherapy for the Treatment of Asthma

Tue, 22 Mar 2016 05:13:25 +0100

What does the latest research tell us about the use of allergen immunotherapy for asthma? Current Opinion in Pulmonary Medicine (Source: Medscape Allergy Headlines)

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Teach-to-Goal Instruction Improves Rescue Inhaler UseTeach-to-Goal Instruction Improves Rescue Inhaler Use

Mon, 21 Mar 2016 09:43:28 +0100

Hospitalized patients with asthma and COPD who received multiple cycles of instruction and practice on inhaler use had fewer acute care needs after discharge in a randomized trial. Medscape Medical News (Source: Medscape Medical News Headlines)



Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately. (Source: Journal of Medical Genetics)



Asthma during pregnancy and congenital malformations: The challenging task of separating the medication effect from asthma itself

Mon, 21 Mar 2016 00:00:00 +0100

We have read with interest the article by Garne et al1 which adds new information on the impact of asthma treatments during pregnancy on the prevalence of congenital malformations. The study concluded that the use of inhaled β2-agonists (short- and long-acting combined) is associated with an increased risk of cleft palate and gastroschisis, whereas the use of inhaled corticosteroids (ICSs) showed no increased risk for any of the examined malformations. We fear however that such a statement could negatively affect the confidence of clinicians and mothers in short-acting β2-agonists (SABAs), specifically salbutamol, which was the most frequently used β2-agonist in this study. (Source: Journal of Allergy and Clinical Immunology)



Areas with high rates of police-reported violent crime have higher rates of childhood asthma morbidity - Beck AF, Huang B, Ryan PH, Sandel MT, Chen C, Kahn RS.

Sun, 20 Mar 2016 19:34:31 +0100

OBJECTIVES: To assess whether population-level violent (and all) crime rates were associated with population-level child asthma utilization rates and predictive of patient-level risk of asthma reutilization after a hospitalization. STUDY DESIGN: A retrospe... (Source: SafetyLit)



YKL-40 is associated with inflammation and MMPs in osteoarthritis

Sun, 20 Mar 2016 18:07:32 +0100

Purpose: YKL-40 is associated with inflammation and tissue injury in diseases such as asthma and rheumatoid arthritis. It has been shown to be produced by macrophages and some tissue cells as well as by cancer cells. Increased circulating YKL-40 levels have been reported in patients with osteoarthritis (OA). However, the role of YKL-40 in OA joints remains largely unknown. In the present study, we investigated the levels of YKL-40 in simultaneously collected plasma, synovial fluid (SF) and cartilage samples from OA patients undergoing knee replacement surgery, and investigated its associations with inflammatory factors and matrix degrading MMP enzymes in an attempt to understand the role of YKL-40 in OA. (Source: Osteoarthritis and Cartilage)

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Fluorinated steroids and their derivatives

Sun, 20 Mar 2016 00:00:00 +0100

This article presents an overview of preparative methods to fluorinated steroids as well as of the uses of these compounds. Graphical abstract (Source: Journal of Fluorine Chemistry)



Coexistence of 2282del4 FLG gene mutation and IL-18 -137G/C gene polymorphism enhances the risk of atopic dermatitis.

Sat, 19 Mar 2016 21:41:02 +0100

CONCLUSIONS: 2282del4 FLG mutation similarly to GG genotype and G-allele in -137 position of IL-18 gene enhance the risk of AD in the Polish population. Coexistence of FLG mutations with GG genotype of IL-18 may be helpful to estimate chances of AD development. PMID: 26985181 [PubMed] (Source: Advances in Dermatology and Allergology)



Prevalence of asthma medical diagnosis among Brazilian adults: National Health Survey, 2013

Sat, 19 Mar 2016 09:19:16 +0100

Conclusions: Although it seems there is asthma diagnosis stability in the country when compared with other researches, we still need public policies for improving the disease management. (Source: Revista Brasileira de Epidemiologia)



Challenges in the Pharmacological Treatment of Geriatric Asthma.

Sat, 19 Mar 2016 05:10:02 +0100

Authors: Agusta F, Battaglia S, Benfante A, Spatafora M, Scichilone N Abstract Asthma in older populations is characterized by frequent comorbid conditions, which increase the risk of side effects and of detrimental interactions between respiratory and non-respiratory drugs. These observations lead to the need to manage asthma in older populations by applying a multidimensional assessment and a multidisciplinary treatment; therefore, we favor the use of the "geriatric" term to define asthma in the elderly. Geriatric asthma is a complex disease, which may not necessarily imply that it is also complicated, although the two conditions may often coexist. On this basis, the switch from an organ-driven management to the holistic approach may be the key factor to attain optimal control of...



Selection and validation of reference house-keeping genes in the J774A1 macrophage cell line for quantitative real-time PCR.

Sat, 19 Mar 2016 03:01:03 +0100

This study also emphasizes the importance of evaluating HKGs used for normalization to ensure the accuracy of qPCR data. PMID: 26985962 [PubMed - in process] (Source: Genetics and Molecular Research)

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Fine particulate matter estimated by mathematical model and hospitalizations for pneumonia and asthma in children

Sat, 19 Mar 2016 02:24:35 +0100

Conclusions: Exposure to PM2.5 was associated with hospitalizations for pneumonia and asthma in children younger than 10 years of age, showing the role of fine particulate matter in child health and providing subsidies for the implementation of preventive measures to decrease these outcomes.Resumo Objetivo: Estimar a associação entre exposição ao material particulado fino com diâmetro aerodinâmico inferior a 2,5 micra (PM2.5) e as internações por pneumonia e asma em crianças. Métodos: Estudo ecológico de séries temporais com indicadores diários de internação por pneumonia e asma, em crianças com até 10 anos, residentes em Taubaté (SP), e concentrações estimadas de PM2.5, entre agosto de 2011 e julho de 2012. Modelo aditivo generalizado de regressão de Poisson foi usado...



Cortisol response to acute stress in asthma: Moderation by depressive mood

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: 15 May 2016 Source:Physiology & Behavior, Volume 159 Author(s): Ana F. Trueba, Erica Simon, Richard J. Auchus, Thomas Ritz Both individuals with asthma and depression show signs of a dysregulated hypothalamus-pituitary-adrenal axis. However, little is known about the cortisol response to stress in the context of co-occurring asthma and depressive mood. Thirty-nine individuals with asthma and 41 healthy controls underwent a combined speech and mental arithmetic stressor. During the course of the laboratory session, salivary cortisol was collected 5 times, with 1 sample at 0min before the stressor and 4 samples at 0, 15, 30 and 45min after the stressor. Depressive mood in the past week was assessed with the Hospital Anxiety and Depression Scale at the beginnin...



Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma

Sat, 19 Mar 2016 00:00:00 +0100

We have used a proteomic approach to identify novel mediators of inflammation in the sputum of a subject with asthma compared with a healthy control subject (see this article's MethodsE1,E2 section in the Online Repository at www.jacionline.org). Using this approach, we determined that follistatin-like 1 (FSTL1) is more than 200-fold highly expressed in the subject with asthma compared with the control subject and was the most highly expressed of the 508 proteins we examined in sputum. FSTL1, a 308 amino acid extracellular glycoprotein that shares 94% identity in man and mouse,1,2 is generated by nonhematopoietic cells such as cells of the mesenchymal lineage (fibroblasts, chondrocytes, osteocytes, adipocytes, cardiomyocytes) by stimuli including TGF-β, IL-1β, TNF-α, and IL-6. (Source: ...



Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study

Sat, 19 Mar 2016 00:00:00 +0100

There is a paucity of studies comparing asthma and chronic obstructive pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) parameters. (Source: Journal of Allergy and Clinical Immunology)



Airway smooth muscle enlargement is associated with protease-activated receptor 2/ligand overexpression in patients with difficult-to-control severe asthma

Sat, 19 Mar 2016 00:00:00 +0100

Asthma is a complex disease with heterogeneous features of airway inflammation and remodeling. The increase in airway smooth muscle (ASM) mass is an essential component of airway remodeling in patients with severe asthma, yet the pathobiological mechanisms and clinical outcomes associated with ASM enlargement remain elusive. (Source: Journal of Allergy and Clinical Immunology)

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Multiple drug allergy

Sat, 19 Mar 2016 00:00:00 +0100

A 16-year-old nonatopic boy with recurrent tonsillitis was admitted to our drug safety clinic because of his history of drug allergy. More than 1 year before, he had an immediate hypersensitivity reaction after oral administration of amoxicillin. He developed rash, pruritus, and dyspnea 10 to 15 minutes after amoxicillin intake. Two months later, because of this adverse event, the patient began taking clarithromycin as an alternative, safe antibiotic. He developed general urticaria 30 minutes after intake. (Source: Annals of Allergy, Asthma and Immunology)



Salivary cotinine measurement for all children with persistent asthma: spit matters

Sat, 19 Mar 2016 00:00:00 +0100

Despite awareness that secondhand smoke (SHS) exacerbates asthma symptoms, more than half of US children with asthma are exposed to SHS,1 and the parent is the primary source of exposure.2,3 Explanations for failure to prevent SHS exposure in the home for children with asthma are multifaceted and not well understood, and significant underreporting of SHS exposure occurs.4 Furthermore, few health care professionals use biomarkers (ie, cotinine) as an objective measure of SHS exposure.5 There has been minimal effort to examine the factors associated with persistent SHS exposure in high-risk children with asthma. (Source: Annals of Allergy, Asthma and Immunology)



Safety of chitosan processed wine in shrimp allergic patients

Sat, 19 Mar 2016 00:00:00 +0100

Wine is an ubiquitous product all over the world, but up to 1 in 10 consumers reports intolerance or allergy-like symptoms after drinking wine.1 Chitosan is a linear polysaccharide and the product of the deacetylation of chitin, the main component of the cell walls of some fungi; the exoskeletons of arthropods, such as crustaceans and insects; and the beaks of cephalopods.2 It also may be used in wine processing. (Source: Annals of Allergy, Asthma and Immunology)



Persistent Mycobacterium abscessus infection secondary to interferon-γ autoantibodies

Sat, 19 Mar 2016 00:00:00 +0100

We present a case of a woman with interferon-γ autoantibodies resulting in persistent Mycobacterium abscessus infection. (Source: Annals of Allergy, Asthma and Immunology)



Residual Neuromuscular Blockade and Adverse Postoperative Outcomes: An Update

Sat, 19 Mar 2016 00:00:00 +0100

Abstract Residual weakness in our post-anesthesia-care-units (PACU) following the intra-operative administration of non-depolarizing neuromuscular blocking agents continues to be a frequent and usually unrecognized occurrence. If satisfactory recovery from these drugs is defined as a train-of-four ratio (TOF) of 0.90 or greater, probably not less than 30 % of patients fail to achieve this level of recovery upon arrival in the PACU. While most health young individuals will tolerate TOF values of 0.70 with no serious sequelae, this is not true of all patients. The elderly and patients with pre-existing conditions such as COPD, asthma, sleep apnea, obesity, and muscle or neurological disease may not be so fortunate. Anesthesia and surgery in the absence of muscle relaxant administra...

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Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates

Sat, 19 Mar 2016 00:00:00 +0100

Conclusions. Asymptomatic presence of picornavirus in the neonatal airway is a potent activator of the topical immune response. This is relevant to understanding the immune potentiating effect of early life exposure to viruses. (Source: The Journal of Infectious Diseases)



Adrenal insufficiency exists for both swallowed budesonide and fluticasone propionate in the treatment of eosinophilic esophagitis

Sat, 19 Mar 2016 00:00:00 +0100

The report by Golekoh et al1 examined the prevalence of adrenal insufficiency in children with eosinophilic esophagitis treated with swallowed fluticasone propionate (FP) or budesonide and found that all patients on budesonide had normal testing. This contrasts with our study,2 in which we documented an adrenal insufficiency prevalence of 43% with budesonide. They consequently explain these contrasting results by suggesting that our study population was treated concomitantly with inhaled corticosteroids for asthma. (Source: The Journal of Pediatrics)



Why Clinical Practice Guidelines Hinder Rather Than Help

Sat, 19 Mar 2016 00:00:00 +0100

Asthma is the leading cause of hospitalization among children. Recognition of inadequate control of asthma stimulated the development of Guidelines by an Expert Panel convened by the National Asthma and Prevention Program of the National Institute of Health. Those Guidelines with several revisions spanning 24 years were well-intentioned but ineffective at altering the continued high prevalence of urgent care and hospitalization among children with asthma. Meanwhile, there is strong evidence that specialists, with their greater clinical experience and knowledge have demonstrated excellent outcome compared with non-specialist care. (Source: Paediatric Respiratory Reviews)



Increased serum VDBP as a risk predictor for steroid resistance in asthma patients

Sat, 19 Mar 2016 00:00:00 +0100

Asthmatic symptoms usually can be controlled with corticosteroids, but partly asthmatic patients do not respond to corticosteroids, steroid resistance (SR) play a significant role in the poorly responding. However, no approach can accurately predict steroid responsiveness in asthma patients, so prediction of SR with noninvasive means has become a critical issue. (Source: Respiratory Medicine CME)



Obesity Risk Class and Asthma Outpatient Service Utilization by the Middle Aged and Elderly in Taiwan

Sat, 19 Mar 2016 00:00:00 +0100

Health costs tend to grow faster than the economy, leading to concerns about the sustainability of health care expenditures [1]. High growth is not necessarily a cause for concern, since good health is highly valued [2]. Also, new health technologies may prove to be value for money[3,4]. However, the level of health care spending might be inefficiently high in most countries [5–8]. The US, for example, has the highest level of health expenditures of all countries, but on average performs rather poorly on health outcomes [9,10]. (Source: Health Policy)

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Clinical Application of the Forced Oscillation Technique.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Shirai T, Kurosawa H Abstract The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory system resistance and reactance during tidal breathing. Recently, its clinical application has spread worldwide with the expansion of commercially available broadband frequency FOT devices, including MostGraph and Impulse Oscillometry. An increasing number of reports have supported the usefulness of the FOT in the management of asthma and chronic obstructive pulmonary disease (COPD). However, the FOT is not a surrogate test for spirometry, but should be used complementarily. Furthermore, reference values are not necessarily available and the interpretation of some measured data is controversial. There is a need to update the international statement...



Prevalence and risk factors of asthma in First Nations children living on reserves in Canada.

Fri, 18 Mar 2016 23:04:02 +0100

CONCLUSIONS: The overall prevalence of ever-asthma and factors associated with ever-asthma in First Nations children living on reserves were similar to those reported for off-reserve Aboriginal children and non-Aboriginal Canadian children. PMID: 26986908 [PubMed - as supplied by publisher] (Source: Canadian Journal of Public Health)



Improved instruction for rescue inhaler use may save lives

Fri, 18 Mar 2016 16:01:37 +0100

Stephen FellerCHICAGO, March 18 (UPI) -- A new method of teaching asthma and COPD patients to properly use rescue inhalers can prevent adverse health events, according to a recent study. (Source: Health News - UPI.com)



Omalizumab reduces colds in children with asthma

Fri, 18 Mar 2016 13:47:00 +0100

Children treated with omalizumab had 27% fewer colds then those treated with guideline-based care. (Source: Clinical Pharmacist)



Rescue inhaler study: New approach increases mastery of life-saving technique

Fri, 18 Mar 2016 12:56:44 +0100

A rescue inhaler can be a lifesaver during an asthma or COPD flareup, but using a rescue inhaler is complicated and misuse is common, putting patients' lives at risk. An education strategy, called teach-to-goal, may help patients use their inhalers properly during these critical times, according to new research. (Source: ScienceDaily Headlines)

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Searching for genes in Schizophrenia.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Wildenauer DB, Schwab SG, Maier W, Lerer B Abstract Decades of research into the etiology of schizophrenia on a phenotypic level, i.e. studies of neuroanatomy, neuropathology, neurophysiology and other areas such as immunology have yielded only fragmentary results. A contribution of genetic factors, has been consistently shown, however, beginning with E. Kraepelin's pioneering studies at the turn of the century. Evidence has accumulated from family-, twin-, and adoption studies. Identical twins have a 48% risk of developing schizophrenia if one of them is affected. In contrast, a 17 % risk is reported for nonidentical twins. These rates are similar to other complex genetic disorders such as diabetes, hypertension and asthma. Advances in the genetic analysis of complex trai...



Evaluation of the improvement of quality of life with Azithromycin in the treatment of eosinophilic nasal polyposis

Fri, 18 Mar 2016 00:00:00 +0100

Conclusion Azithromycin resulted in significant improvement of QoL, assessed by SNOT-22, in the studied population. (Source: Brazilian Journal of Otorhinolaryngology)



A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma

Fri, 18 Mar 2016 00:00:00 +0100

Quilizumab, a humanized IgG1 monoclonal antibody, targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. In patients with mild asthma, quilizumab reduc... (Source: Respiratory Research)



CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation

Fri, 18 Mar 2016 00:00:00 +0100

In conclusion, in the current model of allergic inflammation, CD11b+ cells (monocytes, macrophages, dendritic cells) and Sca-1+ cells (MSCs) are responsible for the beneficial effects of BMDMCs. Significance This study shows that bone marrow-derived mononuclear cells (BMDMCs) are as effective as bone marrow-derived mesenchymal stromal cells (MSCs) in ameliorating experimental asthma. It also demonstrates that not only MSCs present in the pool of BMDMCs are responsible for BMDMCs’ beneficial effects but also monocytes, which are the most important cell population to trigger these effects. All of this is in the setting of a clinically relevant model of severe allergic airways inflammation and thus provides further support for potential clinical use of cell therapy using MSCs, BMDMCs, ...



Reviewer acknowledgement 2015

Fri, 18 Mar 2016 00:00:00 +0100

(Source: Allergy, Asthma and Clinical Immunology)

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Vitamin D and Lung Function Decline in Adults With Asthma: The HUNT Study.

Fri, 18 Mar 2016 00:00:00 +0100

Authors: Brumpton BM, Langhammer A, Henriksen AH, Camargo CA, Chen Y, Romundstad PR, Mai XM Abstract We investigated whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with more lung function decline in adults with asthma and whether this association was modified by smoking status or inhaled corticosteroid (ICS) use. We analyzed data on 395 adults with asthma from the Nord-Trøndelag Health Study (1995-2008), Norway. Plasma 25(OH)D and lung function were measured at baseline, and lung function measurements were repeated at follow-up, approximately 11 years later. Linear regression was used to estimate lung function decline. Participants with low 25(OH)D (<50 nmol/L) had more decline in lung function measurements for forced expiratory volume in 1 second (FEV1) (388 ...



Step-down therapy in well-controlled asthmatic patients

Thu, 17 Mar 2016 21:57:23 +0100

Horiuchi K, Kasahara K, Kuroda Y, Morohoshi H, Hagiwara Y, Ishii G (Source: Journal of Asthma and Allergy)



Factors affecting the QoL of patients with asthma

Thu, 17 Mar 2016 21:50:48 +0100

Uchmanowicz B, Panaszek B, Uchmanowicz I, Rosińczuk J (Source: Patient Preference and Adherence)



Pharmacy Partnership Reduces Pediatric Asthma ReadmissionsPharmacy Partnership Reduces Pediatric Asthma Readmissions

Thu, 17 Mar 2016 17:19:45 +0100

Partnership with a local pharmacy to deliver medications to pediatric asthma patients upon discharge from a satellite facility lacking its own pharmacy was associated with reduced readmissions for asthma. Reuters Health Information (Source: Medscape Allergy Headlines)



Obesity Tied to Higher Asthma Prevalence in WomenObesity Tied to Higher Asthma Prevalence in Women

Thu, 17 Mar 2016 10:10:55 +0100

The overall prevalence of asthma in US adults has also increased, federal health officials say. Medscape Medical News (Source: Medscape Allergy Headlines)

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Evaluation of the immunogenicity of the 13-valent conjugated pneumococcal vaccine in rheumatoid arthritis patients treated with etanercept

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions In RA patients treated with ETA, vaccination with PCV13 is effective and safe, resulting in pAR one and two months after vaccination. Higher age at vaccination was identified as predictors of impaired pAR. The efficacy of vaccination may be more pronounced in younger RA patients. The vaccine is safe in RA patients on ETA. (Source: Joint Bone Spine)



Obesity Linked to Higher Asthma Risk in Women

Thu, 17 Mar 2016 00:00:00 +0100

Experts don't know why, or if losing weight would improve the airway disease (Source: Pulmonary Medicine News - Doctors Lounge)



Novel montelukast sodium-loaded stable oral suspension bioequivalent to the commercial granules in rats.

Thu, 17 Mar 2016 00:00:00 +0100

Authors: Kim DW, Kim YH, Yousaf AM, Kim DS, Kwon TK, Park JH, Kim YI, Park JH, Jin SG, Kim KS, Cho KH, Li DX, Kim JO, Yong CS, Woo JS, Choi HG Abstract To develop a montelukast sodium-loaded stable oral suspension bioequivalent to the commercial granules in rats, several montelukast sodium-loaded suspensions were prepared with a suspending agent, stabilizers and anti-aggregation agents, and their stabilities were investigated by visually observing the sedimentation phenomenon and determining the concentration of the degradation product. Moreover, dissolution and pharmacokinetic studies of the optimized formulation were examined in rats compared to commercial montelukast sodium-loaded granules. Avicel RC-591 (Avicel), a suspending agent, prevented the sedimentation of these suspensi...



Mouth Breathing, another Risk Factor for Asthma: the Nagahama Study

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionMouth breathing may increase asthma morbidity, potentially through increased sensitization to inhaled allergens, which highlights the risk of mouth‐bypass breathing in the “one airway, one disease” concept. The risk of mouth breathing should be well recognized in subjects with allergic rhinitis and in the general population.This article is protected by copyright. All rights reserved. (Source: Allergy)



The NPC2 protein

Thu, 17 Mar 2016 00:00:00 +0100

Dogs are an important source of indoor allergens that cause rhinoconjunctivitis, urticaria, and asthma in sensitized individuals. Can f 1 is reported as a major dog allergen, but other allergens have also been identified. Identification of immunologically important allergens is important for both the diagnosis and treatment of dog allergy. (Source: Annals of Allergy, Asthma and Immunology)

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Interleukin‐9 and interleukin‐17C in chronic rhinosinusitis

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionInflammatory cell expression of IL‐9 and IL‐17C were increased in CRS, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of CRSwNP as well as atopy and may serve as therapeutic targets for disease management. (Source: International Forum of Allergy and Rhinology)



Clinical implications of mucosal remodeling from chronic rhinosinusitis

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionEstablished mucosal remodeling predicts a greater reliance on topical therapies to reach similar clinical endpoints as those without remodeling. (Source: International Forum of Allergy and Rhinology)



Bronchospasm triggered by spinal anaesthesia. Case report and review of the literature

Thu, 17 Mar 2016 00:00:00 +0100

Publication date: Available online 17 March 2016 Source:Colombian Journal of Anesthesiology Author(s): Ana María Rodilla-Fiz, Marta Gómez-Garrido, Fernando Martínez-López, Jose Ángel Monsalve-Naharro, María Girón-La Casa, Alfonso López-Pérez Bronchospasm is a clinical condition that can occur unexpectedly during general anaesthesia, but is extremely rare after spinal anaesthesia. The following is a case presentation of a patient who developed bronchospasm after undergoing spinal anaesthesia not attributable to other causes, and that adds another case to the limited literature. Most publications allude to asthmatic patients, and this is probably the first description about a patient with emphysema-type COPD. Our case shows that although spinal anaesthesia is considered safe...



Nocturnal haemoglobin oxygen desaturation in urban and rural East African paediatric cohorts with and without sickle cell anaemia: a cross-sectional study

Thu, 17 Mar 2016 00:00:00 +0100

Low haemoglobin oxygen saturation (SpO2) predicts complications in children with sickle cell anaemia (SCA) in the North but there are few data from Africa, where the majority of the patients reside. We measured daytime and overnight SpO2 in children with SCA in routine follow-up clinic, and controls without symptoms of SCA, comparing rural (Kilifi, Kenya) and urban (Dar-es-Salaam, Tanzania) cohorts. Daytime SpO2 was lower in 65 Tanzanian children with SCA (TS; median 97 (IQR 94–100)%); p<0.0001) than in 113 Kenyan children with SCA (KS; 99 (98–100)%) and 20 Tanzanian controls (TC; 100 (98–100)%). Compared with 95 Kenyan children with SCA, in 54 Tanzanian children with SCA and 19 TC who returned for overnight oximetry, mean (KS 99.0 (96.7–99.8)%; TS 97.9 (95.4&nda...



Obesity Risk Class and Asthma Outpatient Service Utilization by the Middle Aged and Elderly in Taiwan

Thu, 17 Mar 2016 00:00:00 +0100

The World Health Organization (WHO) has reported that there were about 300 million people suffering from asthma in 2005 around the world. In that same year, asthma was the cause of 255, 0000 deaths.[1] The number of asthma sufferers in the world is projected to increase by 10 million by the year 2025. Global Initiative for Asthma (GINA) has also indicated that asthma was one of the most common chronic health conditions in the world.[2] Indeed, the prevalence rate of asthma is rising in countries all over the world. (Source: Health Policy)

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Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: A systematic review and meta-analysis.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: Evidence was found that short-term exposure to air pollution was associated with increasing risk of hospital utilization for COPD and asthma in the whole population, the elderly and children, but not in people aged 15-64. Children tended to be more susceptible to the effect of air pollution on asthma morbidity. PMID: 26995350 [PubMed - as supplied by publisher] (Source: Environmental Research)



Asthma management in elderly patients

Wed, 16 Mar 2016 21:59:38 +0100

Ozturk AB, Iliaz S (Source: Journal of Asthma and Allergy)



Acupoint Application for Asthma Therapy in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Wed, 16 Mar 2016 21:54:01 +0100

CONCLUSIONS: Acupoint application may be a valid complementary and alternative therapy for asthma in adults. It contributes especially to improving pulmonary function and reducing the levels of interleukin and immunoglobulin E. However, more studies with longer follow-ups are warranted to confirm the current findings. PMID: 26978427 [PubMed - as supplied by publisher] (Source: Forschende Komplementarmedizin)



CDC: Obese Women Have Higher Asthma Prevalence (CME/CE)

Wed, 16 Mar 2016 13:30:00 +0100

(MedPage Today) -- Overall asthma prevalence in U.S. adults also rose in 2013-2014 (Source: MedPage Today Allergy)



Obesity Linked to Higher Asthma Risk in Women

Wed, 16 Mar 2016 13:00:00 +0100

Experts don't know why, or if losing weight would improve the airway disease (Source: U.S. News - Health)

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Indoor Damp and Asthma Exacerbation: A Causal Relationship in Young Children

Wed, 16 Mar 2016 10:50:49 +0100

Wed, 03/16/2016 - 10:50News blog (Source: The Aspergillus Website - updates)



Obesity Linked to Higher Asthma Risk in Women

Wed, 16 Mar 2016 09:03:44 +0100

WEDNESDAY, March 16, 2016 -- As weight rises, so too does the risk for asthma, U.S. health officials report. During the 2011-2014 period, nearly 9 percent of American adults had asthma. Normal-weight folks had asthma rates around 7 percent, while... (Source: Drugs.com - Daily MedNews)



The Program for the Prevention of Childhood Asthma: a specialized care program for children with wheezing or asthma in Brazil

Wed, 16 Mar 2016 03:20:36 +0100

Conclusions : A prevention program for children with asthma is an effective strategy for controlling the disease. Knowledge of local epidemiological and environmental characteristics is essential to reducing the prevalence of the severe forms of asthma, to improving the use of health resources, and to preventing pulmonary changes that could lead to COPD in adulthood. Objetivo : Apresentar o Programa Infantil de Prevenção de Asma (PIPA), assim como as características dos pacientes nele acompanhados. Métodos : O PIPA, implantado em Uruguaiana (RS), tem como população alvo crianças e adolescentes com asma ou suspeita de asma, menores de 18 anos, referidos por pediatras, médicos de atenção primária ou por procura espontânea. Neste estudo retrospectivo, os participantes foram avalia...

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Pollen used to produce allergen extracts

Wed, 16 Mar 2016 00:00:00 +0100

To review the use of pollen for the production of allergen extracts to diagnose and treat allergic diseases, examine the associated regulations, and highlight candidate areas for improvement. (Source: Annals of Allergy, Asthma and Immunology)



Stinging insect identification

Wed, 16 Mar 2016 00:00:00 +0100

It has been reported that the general population is not skillful at identifying stinging insects with the exception of the honeybee. No information is available to evaluate allergy physicians' accuracy with stinging insect identification. (Source: Annals of Allergy, Asthma and Immunology)



Stinging insect identification: Are the allergy specialists any better than their patients?

Wed, 16 Mar 2016 00:00:00 +0100

CONCLUSION: Overall, allergists are more skilled at Hymenoptera identification. Most allergy specialists reported testing for all stinging insects when evaluating insect hypersensitivity, and skin testing was the preferred testing method in nearly 70% of allergists. These data support the practice parameter's recommendation to consider testing for all flying Hymenoptera insects during venom evaluation, which most of the participating allergists surveyed incorporate into their clinical practice. PMID: 26993171 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)



Pollen used to produce allergen extracts.

Wed, 16 Mar 2016 00:00:00 +0100

CONCLUSIONS: Physicians should be aware of the factors responsible for the qualitative and quantitative composition of pollen allergen extracts and the associated regulations to produce suitable extracts to diagnose and treat allergic diseases. Collaboration and cooperation among allergen manufacturing companies and regulatory agencies are necessary. PMID: 26993170 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)



Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs.

Tue, 15 Mar 2016 21:57:03 +0100

Authors: Drummond MB, Kunisaki KM, Huang L Abstract HIV infection has shifted from what was once a disease directly impacting short-term mortality to what is now a chronic illness controllable in the era of effective combination antiretroviral therapy (ART). In this setting, life expectancy for HIV-infected individual is nearly comparable to that of individuals without HIV. Subsequent to this increase in life expectancy, there has been recognition of increased multimorbidity among HIV-infected persons, with prevalence of comorbid chronic illnesses now approaching 65%. Obstructive lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are prevalent conditions associated with substantial morbidity and mortality in the United States. There is overlap in risk...

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Epidemiology of HIV-Associated Lung Disease in the United States.

Tue, 15 Mar 2016 21:57:03 +0100

Authors: Fitzpatrick M, Brooks JT, Kaplan JE Abstract The epidemiology of HIV infection and its pulmonary complications in the United States has evolved significantly over nearly 20 years since the advent of combination antiretroviral therapy. While infectious complications are less of a threat to patients whose immune systems have been restored, many HIV-infected persons in the United States remain at high risk for opportunistic infection because they are unaware of their HIV infection, have difficulty maintaining linkage to care, or maintain inadequate viral control. Bacterial pneumonia and Pneumocystis pneumonia remain significantly more prevalent among HIV-infected persons, and together with seasonal influenza are areas where public health efforts to increase antiretroviral the...



Antifungals May Relieve Asthma, Chronic SinusitisAntifungals May Relieve Asthma, Chronic Sinusitis

Tue, 15 Mar 2016 20:58:50 +0100

A new protocol for testing the sputum of patients with asthma or chronic sinusitis for fungus could help select those who will benefit from antifungal therapies, research shows. Medscape Medical News (Source: Medscape Medical News Headlines)



Women who have more than one C-section 'DON'T harm their babies' health 

Tue, 15 Mar 2016 19:06:45 +0100

The finding is important because it had been feared that Caesarean sections raised the risk of a host of health problems, including obesity and asthma, Aberdeen University experts said. (Source: the Mail online | Health)



[Prevalence of asthma consultations in general practice].

Tue, 15 Mar 2016 14:35:02 +0100

CONCLUSION: Our findings suggest that asthma remains underdiagnosed in general practice in France. In order to address this problem, the development of validated diagnostic tools that can be used in general practice settings, and a better access to spirometry, may be directions to explore in future research. PMID: 26971076 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)



Reslizumab Effective in Chronic Sinusitis With Nasal PolypsReslizumab Effective in Chronic Sinusitis With Nasal Polyps

Tue, 15 Mar 2016 14:13:30 +0100

For a subgroup of patients, an anti-interleukin-5 antibody improved asthma exacerbation rates, lung function, and quality of life, according to a subanalysis of data from two pivotal phase 3 trials. Medscape Medical News (Source: Medscape Allergy Headlines)

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Here's More Evidence That Depression Affects The Entire Body

Tue, 15 Mar 2016 11:30:48 +0100

Here's yet another friendly, scientific reminder that mental health conditions are not within your control. Depression is an illness that can affect your entire body -- potentially on a cellular level, according to a recent study. Researchers from the University of Granada conducted a meta-analysis of 29 previous studies, where they looked at biomarkers in the cells of people with depression before and after treatment with antidepressants and compared them with a healthy control group. In particular, they looked at levels of malondialdehyde -- a biomarker in the body that indicates cell deterioration and oxidative stress -- finding an association between depression and elevated levels of the compound.  Oxidative stress occurs when the body both overproduces and then struggle...



Asthma, Allergies or ISS?

Tue, 15 Mar 2016 05:00:00 +0100

PHILADELPHIA. (Ivanhoe Newswire) -- You can’t catch your breath, and then your doctor treats you for asthma, but it keeps getting worse. It’s a mysterious disease that affects only women, but there’s something simple you can do to change your life. (Source: Medical Headlines From Ivanhoe.com)



Antihistamines for the Treatment of Allergic Rhino-conjunctivitis

Tue, 15 Mar 2016 00:00:00 +0100

Opinion statement Histamine plays an important role in the pathogenesis of allergic rhino-conjunctivitis (ARC). First generation antihistamines are sedative, they cause cognitive and psychomotor impairment, and they are not indicated for the treatment of ARC. Second generation H1-antihistamines, with their improved safety profile and faster and longer duration of action, meet many of the ARIA (Allergic Rhinitis and its Impact on Asthma) optimal antihistamine prerequisites for the treatment of ARC. They are recommended as first line therapy for the treatment of children and adults with ARC and are efficacious in rapidly reducing itching, sneezing and rhinorrhoea. However, they offer suboptimal relief to patients with significant nasal congestion. They are available as oral, intrana...



Mucosal inflammation at the respiratory interface: a zebrafish model

Tue, 15 Mar 2016 00:00:00 +0100

Inflammatory diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease are increasing globally and remain poorly understood conditions. Although attention has long focused on the activation of type 1 and type 2 helper T cells of the adaptive immune system in these diseases, it is becoming increasingly apparent that there is also a need to understand the contributions and interactions between innate immune cells and the epithelial lining of the respiratory system. Cigarette smoke predisposes the respiratory tissue to a higher incidence of inflammatory disease, and here we have used zebrafish gills as a model to study the effect of cigarette smoke on the respiratory epithelium. Zebrafish gills fulfill the same gas-exchange function as the mammalian airways a...



Belastungsinduzierte Atembeschwerden im Sport

Tue, 15 Mar 2016 00:00:00 +0100

Publication date: March 2016 Source:Sports Orthopaedics and Traumatology Sport-Orthopädie - Sport-Traumatologie, Volume 32, Issue 1 Author(s): Jan C. Wüstenfeld, Bernd Wolfarth Belastungsinduzierte asthmatische Symptome und Asthma werden häufig bei hochtrainierten Athleten diagnostiziert. Ein belastungsinduziertes Asthma (EIA) und eine belastungsinduzierte Bronchokonstriktion (EIB) treten, je nach Sportart, in 15-45% aller Hochleistungssportler auf. Das EIA tritt nicht selten auch zusammen mit einer Vocal Cord Dysfunktion (VCD) in Erscheinung, die auch eigenständig als Differentialdiagnose in Betracht gezogen werden muss. Die Therapie basiert auf antiinflammatorischer Medikation (inhalative Glukokortikosteroide) und inhalativen Bronchodilatatoren (z.B. ß2-Agonisten). Im Allgemeine...

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Planned Repeat Cesarean Section at Term and Adverse Childhood Health Outcomes: A Record-Linkage Study

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions Birth by repeat CS, whether planned or unscheduled, was associated with an increased risk of hospitalisation with asthma but no difference in risk of obesity at age 5 y. Greater risk of death and learning disability following unscheduled repeat CS compared to VBAC may reflect complications during labour. Further research, including meta-analyses of studies of rarer outcomes (e.g., cerebral palsy), are needed to confirm whether such risks are similar between delivery groups. (Source: PLoS Medicine)



Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle

Tue, 15 Mar 2016 00:00:00 +0100

Orai (Orai1, Orai2, and Orai3) proteins form a family of highly Ca2+-selective plasma membrane channels that are regulated by stromal-interacting molecules (STIM1 and STIM2); STIM proteins are Ca2+ sensors located in the membrane of the endoplasmic reticulum. STIM and Orai proteins are expressed in vascular and airway smooth muscle and constitute the molecular components of the ubiquitous store-operated Ca2+ entry pathway that mediate the Ca2+ release-activated Ca2+ current. STIM/Orai proteins also encode store-independent Ca2+ entry pathways in smooth muscle. Altered expression and function of STIM/Orai proteins have been linked to vascular and airway pathologies, including restenosis, hypertension, and atopic asthma. In this review we discuss our current understanding of Orai proteins an...



Increased expression of nuclear factor of activated T cells 1 drives IL-9–mediated allergic asthma

Tue, 15 Mar 2016 00:00:00 +0100

We reported recently that targeted deletion of NFATc1 in T cells resulted in inhibition of TH2 and TH17 differentiation.2 (Source: Journal of Allergy and Clinical Immunology)



Vitamin D in Asthma. Is the Golden Bullet Losing Its Luster?

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Upham JW, Sly PD PMID: 26977965 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)



Asthma: Airways That Are Hyperactive by Design.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Oliver BG, Black J PMID: 26977964 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)

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Corticosteroids in COPD or Asthma Does Not Decrease Lung SCCCorticosteroids in COPD or Asthma Does Not Decrease Lung SCC

Mon, 14 Mar 2016 10:07:33 +0100

This study examined the association between corticosteroid use in asthma and COPD and the risk of lung squamous cell carcinoma. BMC Pulmonary Medicine (Source: Medscape Today Headlines)



Morbidity associated with oral corticosteroids in patients with severe asthma

Mon, 14 Mar 2016 00:00:00 +0100

Cross-sectional primary care record studies show that 0.9% of the adult population receive regular oral corticosteroids (OCS). Prescriptions have increased steadily over the past 20 years, presumably reflecting an increasingly elderly and infirm population.1 Respiratory conditions (mainly airway diseases) are responsible for 25–40% of these OCS prescriptions,1 2 by some way the largest proportion of any specialty. Against this background, it is surprising and disappointing that little is known about morbidity due to OCS usage in patients with airway disease and we remain in the unsatisfactory position of having to extrapolate from studies carried out in non-respiratory conditions. Better information in an airway disease population is important as we are approaching the biologica...



Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry

Mon, 14 Mar 2016 00:00:00 +0100

Conclusions Oral corticosteroid-related adverse events are common in severe asthma. New treatments which reduce exposure to oral corticosteroids may reduce the prevalence of these conditions and this should be considered in cost-effectiveness analyses of these new treatments. (Source: Thorax)



Man in the bubble

Mon, 14 Mar 2016 00:00:00 +0100

A 46-year-old man, with history of asthma without regular medication, presented with persistent dyspnoea and wheezes. He received endotracheal intubation with conventional ventilator support for acute respiratory failure with severe acidosis. Acute desaturation developed on the next day. The following thoracic and abdominal CT disclosed severe subcutaneous emphysema (figure 1, short arrow), pneumomediastinum (figure 1, long arrow), pneumoperitoneum (figure 2, asterisk) and even pneumoscrotum (figure 3, arrowhead). After aggressive treatment with systemic steroids, the endotracheal tube was extubated 3 days later in a highly improved condition. The patient was discharged uneventfully, and had regular outpatient visits. ContributorsY-HL and C-KP managed the patient. Y-HL prepared the ma...



Comparison of early effects of budesonide/formoterol maintenance and reliever therapy with fluticasone furoate/vilanterol for asthma patients requiring step-up from inhaled corticosteroid monotherapy

Mon, 14 Mar 2016 00:00:00 +0100

Conclusion As compared with the FF/VI group, the SMART group achieved a greater improvement in FeNO, small airway parameters regarding IOS and ACQ score, in patients with airway inflammation and uncontrolled symptoms treated with a medium dose of ICS alone. In this 4-week study, these two ICS/LABA combination therapies showed different treatment outcomes; they must be investigated further to clarify suitable patient characters and the long term efficacies for each combination. (Source: Pulmonary Pharmacology and Therapeutics)

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Pharmacokinetics of indacaterol and mometasone furoate delivered alone or in a free or fixed dose combination in healthy subjects

Mon, 14 Mar 2016 00:00:00 +0100

Conclusions The QMF149 fixed dose combination treatment showed comparable systemic exposure to the free combination and monotherapy treatments in terms of AUC0-24h,ss and Cmax,ss for both indacaterol and mometasone furoate, indicating an absence of clinically relevant PK or biopharmaceutical interactions. These data support further development of QMF149 without dose adjustment. (Source: Pulmonary Pharmacology and Therapeutics)



Comparison of the clinical effects of combined salmeterol/fluticasone delivered by dry powder or pressurized metered dose inhaler

Mon, 14 Mar 2016 00:00:00 +0100

Publication date: April 2016 Source:Pulmonary Pharmacology & Therapeutics, Volume 37 Author(s): Masayuki Hojo, Toshihiro Shirai, Junko Hirashima, Motoyasu Iikura, Haruhito Sugiyama The salmeterol/fluticasone combination (SFC) inhaler is currently the most widely used maintenance drug for asthmatics worldwide. Although the effectiveness of SFC as either a dry powder inhaler (DPI) or a pressurized metered dose inhaler (pMDI) is well documented, there is limited data comparing the clinical efficacies of the two devices. To address this issue, we carried out a randomized crossover trial in which asthmatic patients (n = 47; mean age, 62.5 ± 16.5 years old) received a 12-week treatment of SFC DPI (50/250 μg twice daily) or SFC pMDI (four puffs of 25/125 μg daily). After a...



Effects of low- versus high-dose fluticasone propionate/formoterol fumarate combination therapy on AMP challenge in asthmatic patients: A double-blind, randomised clinical trial

Mon, 14 Mar 2016 00:00:00 +0100

Conclusions A significant dose-response was found between low- and high-dose fluticasone/formoterol in the post hoc subgroup (patients who received both doses), but not in the overall population, with the higher dose demonstrating a greater reduction in airway responsiveness to AMP. (Source: Pulmonary Pharmacology and Therapeutics)



Pharmacological effects of lysozyme on COPD and bronchial asthma with sputum: A randomized, placebo-controlled, small cohort, cross-over study

Mon, 14 Mar 2016 00:00:00 +0100

Conclusion LYS, a mucolytic agent, has capability to improve the function of peripheral airways in patients with COPD, which leads to improvements of the patients' symptoms and QOL. (Source: Pulmonary Pharmacology and Therapeutics)



Intranasal Administration of Recombinant Mycobacterium smegmatis Inducing IL-17A Autoantibody Attenuates Airway Inflammation in a Murine Model of Allergic Asthma

Mon, 14 Mar 2016 00:00:00 +0100

Asthma is a chronic inflammatory disorder, previous studies have shown that IL-17A contributes to the development of asthma, and there is a positive correlation between the level of IL-17A and the severity of disease. Here, we constructed recombinant Mycobacterium smegmatis expressing fusion protein Ag85A-IL-17A (rMS-Ag85a-IL-17a) and evaluated whether it could attenuate allergic airway inflammation, and further investigated the underlying mechanism. In this work, the murine model of asthma was established with ovalbumin, and mice were intranasally vaccinated with rMS-Ag85a-IL-17a. Autoantibody of IL-17A in sera was detected, and the airway inflammatory cells infiltration, the local cytokines and chemokines production and the histopathological changes of lung tissue were investigated. We f...

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Outcomes of modified endoscopic Lothrop in aspirin‐exacerbated respiratory disease with nasal polyposis

Mon, 14 Mar 2016 00:00:00 +0100

ConclusionComplete sphenoethmoidectomy, maxillary antrostomy, and EMLP is successful in a significant majority of patients with AERD and CRSwNP. It is well tolerated with a low complication rate and facilitates successful ongoing medical management of the condition in patients with AERD. (Source: International Forum of Allergy and Rhinology)



Reformulating the Common Sense Model of Self-Regulation: Toward Parent-Child Shared Regulation

Mon, 14 Mar 2016 00:00:00 +0100

Asthma is one of the most common chronic diseases of childhood with nearly 7 million children affected in the United States. Nonadherence to controller medication is a substantial issue that results in higher pediatric asthma disease morbidity. The common sense model of self-regulation is a useful theoretical framework to understand chronic disease self-management in adults, but has not been used in the context of pediatric chronic disease. Using Fawcett’s framework, the authors analyze and evaluate the common sense model. To conclude, the authors propose a reformulation of the model that incorporates parent-child shared regulation of pediatric asthma. (Source: Nursing Science Quarterly)



Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of untreated asthma and it increases cell proliferation along with fibronectin production in airway constitutive cells

Mon, 14 Mar 2016 00:00:00 +0100

Type 2 helper T-cell cytokines including IL-13 play a central role in the pathogenesis of bronchial asthma (BA). During the course of our research, our attention was drawn to dipeptidyl peptidase-4 (DPP4) as o... (Source: Respiratory Research)



Epidemiology of HIV-Associated Lung Disease in the United States

Mon, 14 Mar 2016 00:00:00 +0100

Semin Respir Crit Care Med 2016; 37: 181-198DOI: 10.1055/s-0036-1572556The epidemiology of HIV infection and its pulmonary complications in the United States has evolved significantly over nearly 20 years since the advent of combination antiretroviral therapy. While infectious complications are less of a threat to patients whose immune systems have been restored, many HIV-infected persons in the United States remain at high risk for opportunistic infection because they are unaware of their HIV infection, have difficulty maintaining linkage to care, or maintain inadequate viral control. Bacterial pneumonia and Pneumocystis pneumonia remain significantly more prevalent among HIV-infected persons, and together with seasonal influenza are areas where public health efforts to increase antiretro...



Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs

Mon, 14 Mar 2016 00:00:00 +0100

Semin Respir Crit Care Med 2016; 37: 277-288DOI: 10.1055/s-0036-1578801HIV infection has shifted from what was once a disease directly impacting short-term mortality to what is now a chronic illness controllable in the era of effective combination antiretroviral therapy (ART). In this setting, life expectancy for HIV-infected individual is nearly comparable to that of individuals without HIV. Subsequent to this increase in life expectancy, there has been recognition of increased multimorbidity among HIV-infected persons, with prevalence of comorbid chronic illnesses now approaching 65%. Obstructive lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are prevalent conditions associated with substantial morbidity and mortality in the United States. There is over...

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Reversion of Asthmatic Complications and Mast Cell Signalling Pathways in BALB/c Mice Model Using Quercetin Nanocrystals

Sun, 13 Mar 2016 23:34:01 +0100

(Source: Journal of Biomedical Nanotechnology)



Nasal polyps in patients with asthma

Sun, 13 Mar 2016 20:36:58 +0100

Langdon C, Mullol J (Source: Journal of Asthma and Allergy)



Diagnosis and investigation in the severe asthma clinic.

Sun, 13 Mar 2016 19:46:01 +0100

Authors: Wark PA, Hew M, Maltby S, McDonald VM, Gibson PG Abstract Severe asthma is recognised as an important and emerging area of unmet need in asthma. The assessment of severe asthma should include three steps; (1) determining the diagnosis of asthma, including verification that the disease is severe asthma, (2) assessing comorbidities and contributing factors that will impact on clinical severity, as well as (3) assessing asthma phenotypes. These steps recognize the importance of heterogeneity in asthma as a key factor that determines the disease course and increasingly the choice of successful therapy. This assessment should be undertaken systematically and is best done by an expert multidisciplinary team. Here, we will outline the important aspects that should be included in ...



Resolution of Rac-Bambuterol via Diastereoisomeric Salt Formation with o-Chloromandelic Acid and Differences in the Enantiomers' Pharmacodynamical Effects in Guinea Pigs and Beagles.

Sun, 13 Mar 2016 10:57:02 +0100

In this study an enantioseparation method for rac-bambuterol (5-(2-(tert-butylamino)-1-hydroxyethyl)-1,3-phenylene bis(dimethylcarbamate)) via diastereoisomeric salt formation with o-chloromandelic acid was developed. The enantiomeric excess (ee) values and chemical purities of the desired products were confirmed by high-performance liquid chromatography (HPLC) using chiral stationary phase and reverse-phase HPLC analyses, respectively. The ee values and the chemical purities both exceeded 99%. Animal experiments showed that (R)-bambuterol was a potent inhibitor for histamine-induced asthma reactions. (S)-bambuterol was ineffective in relaxing the airways. Both enantiomers increased heart rates in beagles. Therefore, replacing rac-bambuterol with (R)-bambuterol could be beneficial for asth...



Allergen extracts and recombinant proteins: comparison of efficiency of in vitro allergy diagnostics using multiplex assay on a biological microchip

Sun, 13 Mar 2016 00:00:00 +0100

Immunological test systems for diagnostics of type I hypersensitivity involve the following types of antigens: whole allergen extracts, individual highly purified proteins and their recombinant analogues. The ... (Source: Allergy, Asthma and Clinical Immunology)

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Enhancing the use of Asthma and COPD Assessment Tools in Balearic Primary Care (ACATIB): a region-wide cluster-controlled implementation trial.

Sat, 12 Mar 2016 19:49:02 +0100

The objective of this study was to assess the effect of an educational intervention programme on the use of the Asthma Control Test (ACT), modified Medical Research Council (mMRC) and COPD Assessment Test (CAT) among primary care settings of the Balearic Islands, Spain. In this region-wide cluster-controlled implementation study, an educational intervention on the use of respiratory health status tools was provided to primary care practices in Mallorca (intervention group). Practices in Ibiza and Menorca functioned as control practices. Written and multimedia materials were provided to all participants to educate their colleagues. Primary outcome was the difference between intervention and control practices in the percentage of practices that increased the use-and recording-of ACT, CAT and...