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Last Build Date: Tue, 22 Mar 2016 08:30:19 +0100

 



Anxiety symptoms in young people with autism spectrum disorder attending special schools: Associations with gender, adaptive functioning and autism symptomatology

Fri, 18 Mar 2016 00:00:00 +0100

Anxiety-related problems are among the most frequently reported mental health difficulties in autism spectrum disorder. As most research has focused on clinical samples or high-functioning children with autism spectrum disorder, less is known about the factors associated with anxiety in community samples across the ability range. This cross-sectional study examined the association of gender, age, adaptive functioning and autism symptom severity with different caregiver-reported anxiety symptoms. Participants were caregivers of 241 children (6–18 years old) with autism spectrum disorder attending special schools in Singapore. Measures included the Spence Children’s Anxiety Scale and assessments of overall emotional, behavioural and adaptive functioning. Caregivers reported more ...

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Psychiatric Diagnoses among an HIV-Infected Outpatient Clinic Population

Wed, 16 Mar 2016 00:00:00 +0100

As individuals with HIV infection are living longer, the management of psychiatric disorders has increasingly been incorporated into comprehensive care. Individuals were recruited from an outpatient HIV clinic to assess the prevalence and related associations of current psychiatric disorders and biomarkers. Of the 201 participants who completed the interviews, the median age was 43.5 years, and the majority was male and African American. Most were receiving HIV therapy and 78% of those had achieved virologic suppression. Prevalent psychiatric diagnoses included major depressive disorder, generalized anxiety, and agoraphobia. Alcohol and cocaine/crack abuse and dependence were common substance use disorders. Current receipt of HIV therapy was less common among those diagnosed with generaliz...



Therapist-supported Internet cognitive behavioural therapy for anxiety disorders in adults.

Sat, 12 Mar 2016 00:00:00 +0100

CONCLUSIONS: Therapist-supported ICBT appears to be an efficacious treatment for anxiety in adults. The evidence comparing therapist-supported ICBT to waiting list, attention, information, or online discussion group only control was low to moderate quality, the evidence comparing therapist-supported ICBT to unguided ICBT was very low quality, and comparisons of therapist-supported ICBT to face-to-face CBT were low quality. Further research is needed to better define and measure any potential harms resulting from treatment. These findings suggest that therapist-supported ICBT is more efficacious than a waiting list, attention, information, or online discussion group only control, and that there may not be a significant difference in outcome between unguided CBT and therapist-supported ICBT;...



Diagnosing Agoraphobia

Fri, 04 Mar 2016 00:00:00 +0100

(Source: About.com Generalized Anxiety)



[ADH/D and impulsiveness: Prevalence of impulse control disorders and other comorbidities, in 81 adults with attention deficit/hyperactivity disorder (ADH/D)].

Thu, 03 Mar 2016 08:12:01 +0100

CONCLUSION: ADH/D in adults continues to be unrecognized in France. The aim of this study was to evaluate the prevalence of impulse control disorders, psychiatric and addictive comorbidities in adults with ADH/D. The results enable us to appreciate quantitative and qualitative data for 81 French adults with ADH/D. This disorder rarely remains isolated and is often associated with many others, especially anxiety and mood disorders. We also observed that impulsivity stays at the heart of the ADH/D, either through impulsive behaviours or addictive disorders. Considering the lack of studies with ADH/D adults, it is difficult to compare our data. The diagnosis of ADH/D is complex and stays controversial, moreover the strong prevalence of comorbidities points out the importance of differential ...



Is Religious Coping a Moderator Of Perceived Control and Panic Symptoms in African American Adults?

Wed, 02 Mar 2016 00:00:00 +0100

Extant research has established a strong association between perceived control and anxiety; however, limited work has examined perceived control within the context of fear-based anxiety disorders and in ethnic minority populations. Further, scant attention has been paid to protective factors that may moderate the relationship between perceived control and anxiety. The current study investigated the relationship between perceived control, positive religious coping, and panic-related fears in a community-based African American adult sample (N = 91, mean age = 38, 91% female). Results from hierarchical linear regression indicated that perceived control significantly predicted all panic subscales (i.e., total panic symptoms, agoraphobic fears, social phobia fears, interoceptive fears); however...

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Mindfulness-Based Exposure Strategies as a Transdiagnostic Mechanism of Change: An Exploratory Alternating Treatment Design.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Alex Brake C, Sauer-Zavala S, Boswell JF, Gallagher MW, Farchione TJ, Barlow DH Abstract The present study explored whether distress reduction in response to strong negative emotions, a putative transdiagnostic mechanism of action, is facilitated by mindfulness strategies. Seven patients (mean age=31.14years, SD=12.28, range 19-48 years, 43% female, 86% Caucasian) with heterogeneous anxiety disorders (i.e., panic disorder with or without agoraphobia, social anxiety, generalized anxiety) were assigned a randomized order of weeklong blocks utilizing either mindfulness- or avoidance-based strategies while ascending a 6-week emotion exposure hierarchy. Participants completed three exposures per block and provided distress and avoidance use ratings following each exposure. Anxi...



20 Tips to Recover from Agoraphobia

Fri, 26 Feb 2016 18:45:34 +0100

Agoraphobia is a stressful phobic disorder that can take years to overcome. There are varying degrees of the illness. Some agoraphobics are so severe, they can’t leave their beds, while others only have a few days here and there where leaving the house seems too daunting a task. Agoraphobics can be scared of traveling or being in open spaces. They can be scared of going out alone or of being made fun of. They may fear failure and embarrassment in the outside world, including the workforce. They can have strained relationships with loved ones and struggle to form new relationships. They can have monetary problems, as most are unable to maintain a job or a career. Having had the disorder myself, I know it is not easy. Being stuck in fear can be just as debilitating as being physically p...



Sex, Sexual Orientation, Gender Atypicality, and Indicators of Depression and Anxiety in Childhood and Adulthood.

Fri, 26 Feb 2016 00:00:00 +0100

Authors: Petterson LJ, VanderLaan DP, Vasey PL Abstract The current study evaluated the possibility that greater negative mental health outcomes reported among gay, lesbian, and gender-atypical individuals, compared to gender-typical individuals, are present in childhood and persist into adulthood. Sex and sexual orientation differences in self-reported adulthood and recalled childhood indicators of depression and anxiety and their association with current and retrospectively reported gender (a)typicality were examined in a non-clinically recruited community sample of Canadian heterosexual men (n = 98), heterosexual women (n = 142), gay men (n = 289), and lesbian women (n = 69). Indicators of depression and anxiety were constructed based on diagnostic criteria for generaliz...



Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative

Mon, 15 Feb 2016 00:00:00 +0100

Abstract In the current review, we reconceptualize a categorical diagnosis—panic disorder and agoraphobia—in terms of two constructs within the domain “negative valence systems” suggested by the Research Domain Criteria initiative. Panic attacks are considered as abrupt and intense fear responses to acute threat arising from inside the body, while anxious apprehension refers to anxiety responses to potential harm and more distant or uncertain threat. Taking a dimensional view, panic disorder with agoraphobia is defined with the threat‐imminence model stating that defensive responses are dynamically organized along the dimension of the proximity of the threat. We tested this model within a large group of patients with panic disorder and agoraphobia (N = 369 and N = 124 in ...



Reconciling RDoC and DSM approaches in clinical psychophysiology and neuroscience

Mon, 15 Feb 2016 00:00:00 +0100

Abstract The Research Domain Criteria (RDoC) initiative endeavors to foster a science of psychopathology based around dimensions of brain‐behavior relationships as opposed to subjectively based diagnostic categories. A rapidly accumulating array of transdiagnostic commonalities, across multiple objective and subjective measures, underscores the clear potential of this initiative. At the same time, a road map for guiding future RDoC research efforts is needed that draws upon the wealth of extant disorder‐specific findings. In this issue, Hamm and colleagues provide an example of conceptualizing within‐disorder processes in terms of dimensional brain‐behavior relationships that advances the understanding of panic disorder with agoraphobia beyond the conventional nosological framework...

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Meet the two Elaines speaking up for libraries

Tue, 09 Feb 2016 17:41:37 +0100

“I can remember getting my first – what I thought of as ‘grown up’ book – out of the library. It was John Steinbeck, The Grapes Of Wrath and I walked down the street being proud of having such a big book.” Elaine Brooks has worked in libraries all her life, and so has her friend and fellow UNISON member Elaine Cotterell. Today – like the Joad family in the The Grapes Of Wrath – they’ve made a journey for the sake of improvement. The Elaines have travelled from Lancashire to London to speak up for local libraries. There are currently 74 libraries in Lancashire County, but by the end of the year there will be 34. Only after a three-month consultation will they know which of the 40 libraries are to be closed. The Elaines are campaigning against this because they know how...



Agoraphobia With and Without Panic Disorder: A 20-Year Follow-up of Integrated Exposure and Psychodynamic Therapy

Mon, 01 Feb 2016 06:00:00 +0100

Abstract: The aim of the current study was to compare the 20-year outcome in panic disorder with agoraphobia (PD with AG) and agoraphobia without panic disorder (AG without PD) patients after inpatient psychological treatment. Of 53 eligible patients having completed a medication-free integrated exposure and psychodynamic treatment, 38 (71.7%)—25 PD with AG and 13 AG without PD patients—attended 20-year follow-up. AG without PD patients improved less than PD with AG patients did on primary outcome measures. In the PD with AG group, there were large uncontrolled effect sizes ( (Source: The Journal of Nervous and Mental Disease)



Facing the fear – clinical and neural effects of cognitive behavioural and pharmacotherapy in panic disorder with agoraphobia

Fri, 22 Jan 2016 00:00:00 +0100

Cognitive behavioural therapy (CBT) and pharmacological treatment with selective serotonin or serotonin-noradrenalin reuptake inhibitors (SSRI/SSNRI) are regarded as efficacious treatments for panic disorder with agoraphobia (PD/AG). However, little is known about treatment-specific effects on symptoms and neurofunctional correlates. (Source: European Neuropsychopharmacology)



Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis

Fri, 22 Jan 2016 00:00:00 +0100

In conclusion, the quality of evidence for the efficacy of propranolol at present is insufficient to support the routine use of propranolol in the treatment of any of the anxiety disorders. (Source: Journal of Psychopharmacology)



High prevalence of psychiatric disorders in skin‐restricted lupus patients: a case‐controlled study

Fri, 08 Jan 2016 00:00:00 +0100

ConclusionsThis study demonstrates a high prevalence of several psychiatric disorders (anxiety, depression, suicide risk, alcohol dependence) in SRL patients.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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High prevalence of psychiatric disorders in skin-restricted lupus patients: a case-controlled study.

Fri, 08 Jan 2016 00:00:00 +0100

CONCLUSIONS: This study demonstrates a high prevalence of several psychiatric disorders (anxiety, depression, suicide risk, alcohol dependence) in SRL patients. This article is protected by copyright. All rights reserved. PMID: 26748551 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



Pro198Leu polymorphism in the oxidative stress gene, glutathione peroxidase-1, is associated with a gender-specific risk for panic disorder.

Fri, 25 Dec 2015 01:08:04 +0100

CONCLUSIONS: GPX1 Pro198Leu and OGG1 Ser326Cys polymorphisms were not associated with PD risk in Turkish patients. However, a gender-specific effect of GPX1 Pro198Leu C allele may be associated with PD development. PMID: 25666858 [PubMed - in process] (Source: International Journal of Psychiatry in Clinical Practice)



Ectomorphic somatotype and joint hypermobility are linked in panic and agoraphobic patients: a case-control study.

Fri, 25 Dec 2015 01:08:04 +0100

CONCLUSIONS: Since PA may be associated with JH, it is suggested that the relationship found between panic and ectomorphic somatotype might be mediated through JH. PMID: 24527884 [PubMed - indexed for MEDLINE] (Source: International Journal of Psychiatry in Clinical Practice)



A human open field test reveals thigmotaxis related to agoraphobic fear

Mon, 21 Dec 2015 00:00:00 +0100

Thigmotaxis refers to a specific behavior of animals, i.e. to stay close to walls when exploring an open space. Such behavior can be assessed with the open field test (OFT), which is a well-established indicator of animal fear. The detection of similar open field behavior in humans may verify the translational validity of this paradigm. Enhanced thigmotaxis related to anxiety may suggest the relevance of such behavior for anxiety disorders, especially agoraphobia. (Source: Biological Psychiatry)



[The prevalence of common mental disorders in the population of adult Poles by sex and age structure - an EZOP Poland study].

Sun, 20 Dec 2015 14:41:55 +0100

CONCLUSIONS: Indices of prevalence obtained in the EZOP Poland study differ from the indices of prevalence of mental disorders described earlier in other countries. Lower values were found in Poland for affective disorders and some anxiety disorders. Only alcohol abuse was diagnosed more often than in other studies using similar methods except Ukraine, where this disorder was diagnosed with similar frequency. PMID: 25844407 [PubMed - indexed for MEDLINE] (Source: Psychiatria Polska)

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Constraint and loneliness in agoraphobia: an empirical investigation.

Wed, 02 Dec 2015 22:17:52 +0100

Authors: Pehlivanidis A, Koulis S, Papakostas Y Abstract While progress in the aetiopathology and treatment of panic disorder is indisputable, research regarding agoraphobia lacks behind. One significant-yet untested- theory by Guidano and Liotti, suggests the existence of inner representations of fear of "constraint" and fear of "loneliness" as two major schemata, important in the pathogenesis and manifestation of agoraphobia. Activation of these schemata may occur in situations in which the patient: (a) feels as in an inescapable trap (constraint) or (b) alone, unprotected and helpless (loneliness). Upon activation, the "constraint" schema elicits such symptoms as asphyxiation, chest pain, difficult breathing, motor agitation and muscular tension, while the "loneliness" schema el...



Serum biomarkers predictive of depressive episodes in panic disorder

Tue, 24 Nov 2015 00:00:00 +0100

Publication date: Available online 24 November 2015 Source:Journal of Psychiatric Research Author(s): M.G. Gottschalk, J.D. Cooper, M.K. Chan, M. Bot, B.W.J.H. Penninx, S. Bahn Panic disorder with or without comorbid agoraphobia (PD/PDA) has been linked to an increased risk to develop subsequent depressive episodes, yet the underlying pathophysiology of these disorders remains poorly understood. We aimed to identify a biomarker panel predictive for the development of a depressive disorder (major depressive disorder and/or dysthymia) within a 2-year-follow-up period. Blood serum concentrations of 165 analytes were evaluated in 120 PD/PDA patients without depressive disorder baseline diagnosis (6-month-recency) in the Netherlands Study of Depression and Anxiety (NESDA). We assessed t...



Functional MRI activation in response to panic-specific, non-panic aversive, and neutral pictures in patients with panic disorder and healthy controls.

Sat, 21 Nov 2015 21:38:03 +0100

This study investigated activation response patterns to stimulation with individually selected panic-specific pictures in patients with panic disorder with agoraphobia (PDA) and healthy control subjects using functional magnetic resonance imaging (fMRI). Structures of interest were the prefrontal, cingulate, and insular cortex, and the amygdalo-hippocampal complex. Nineteen PDA subjects (10 females, 9 males) and 21 healthy matched controls were investigated using a Siemens 3-Tesla scanner. First, PDA subjects gave Self-Assessment Manikin (SAM) ratings on 120 pictures showing characteristic panic/agoraphobia situations, of which 20 pictures with the individually highest SAM ratings were selected. Twenty matched pictures showing aversive but not panic-specific stimuli and 80 neutral pictures...



[An integrative and transdiagnostic relaxation protocol for anxious patients. Results of a pilot study].

Fri, 20 Nov 2015 15:28:39 +0100

DISCUSSION: The results of this open study showed that this program significantly decreases the level of trait anxiety, depression and worry. The integrative and transdiagnostic relaxation program could represent an accessible and effective treatment to reduce anxious and depressive symptoms in various anxiety disorders. Future research should address the development of controlled trials assessing the impact of the different dimensions of anxiety and the long-term effects of this protocol. PMID: 25132015 [PubMed - indexed for MEDLINE] (Source: L Encephale)



[Psychiatric disorders and associated factors in patients with epilepsy in Fez, Morocco].

Fri, 20 Nov 2015 15:28:39 +0100

This study was conducted in order to determine the prevalence and nature of the psychiatric disorders and the associated factors in patients with idiopathic epilepsy. METHODS: A cross-sectional study was conducted over a period of eighteen months in the psychiatric unit of the University Hospital Hassan II of Fez (Morocco). A questionnaire was completed by the included patients, which specified: the socio-demographic data, personal and family history, and the clinical features of epilepsy and its management. Psychiatric disorders were identified by the Mini International Neuropsychiatric Interview test (MINI). The severity of the depression and anxiety symptoms was investigated using the Beck Depression Inventory (BDI) and the Hamilton Rating Scale. RESULTS: Eighty-nine patients me...

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Functional MRI activation in response to panic-specific, non-panic aversive, and neutral pictures in patients with panic disorder and healthy controls

Thu, 19 Nov 2015 00:00:00 +0100

This study investigated activation response patterns to stimulation with individually selected panic-specific pictures in patients with panic disorder with agoraphobia (PDA) and healthy control subjects using functional magnetic resonance imaging (fMRI). Structures of interest were the prefrontal, cingulate, and insular cortex, and the amygdalo-hippocampal complex. Nineteen PDA subjects (10 females, 9 males) and 21 healthy matched controls were investigated using a Siemens 3-Tesla scanner. First, PDA subjects gave Self-Assessment Manikin (SAM) ratings on 120 pictures showing characteristic panic/agoraphobia situations, of which 20 pictures with the individually highest SAM ratings were selected. Twenty matched pictures showing aversive but not panic-specific stimuli and 80 neutral pictures...



Dependent personality, separation anxiety disorder and other anxiety disorders in OCD

Thu, 05 Nov 2015 00:00:00 +0100

ConclusionsThe results suggest that Sep‐AD in childhood and these other anxiety disorders in adulthood are consequences of dependent personality disorder (for agoraphobia and panic disorder) or introversion (for social phobia). It is unknown whether these results would be similar in a non‐OCD sample. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Personality and Mental Health)



Effectiveness of a transdiagnostic internet-based protocol for the treatment of emotional disorders versus treatment as usual in specialized care: study protocol for a randomized controlled trial

Sat, 31 Oct 2015 00:00:00 +0100

In this study, we aim to test the effectiveness of EmotionRegulation, a new transdiagnostic Internet-based protocol for unipolar mood disorders, five anxiety disorders (panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder and anxiety disorder not otherwise specified), and obsessive-compulsive disorder in comparison to treatment as usual as provided in Spanish public specialized mental health care. We will also study its potential impact on basic temperament dimensions (neuroticism/behavioral inhibition and extraversion/behavioral activation). Expectations and opinions of patients about this protocol will also be studied.Methods/DesignThe study is a randomized controlled trial. 200 participants recruited in specialized care will be allocated to one of two treat...



The overlap between anxiety, depression, and obsessive-compulsive disorder.

Fri, 23 Oct 2015 10:56:02 +0100

Authors: Goodwin GM Abstract The anxiety disorders include generalized anxiety disorder, specific phobia, social phobia, agoraphobia, and panic disorder. In addition to the specific symptoms of these disorders, there may be a common experience of anxiety and even dysphoria across the conditions, and of course recourse to the same drug or choice of drugs for treatment. This overlap probably occurs because of universal dimensions of distress or negative affectivity, a shared genetic predisposition, and a common neurobiology Evidence of shared genes is still based mainly on twin studies, but the shared neurobiology can be investigated directly by the investigation of emotional or cognitive bias either behaviorally or using functional brain imaging. This intermediate phenotype can then...



Epidemiology of anxiety disorders in the 21st century.

Fri, 23 Oct 2015 10:56:02 +0100

Authors: Bandelow B, Michaelis S Abstract Anxiety disorders, including panic disorder with or without agoraphobia, generalized anxiety disorder, social anxiety disorder, specific phobias, and separation anxiety disorder, are the most prevalent mental disorders and are associated with immense health care costs and a high burden of disease. According to large population-based surveys, up to 33.7% of the population are affected by an anxiety disorder during their lifetime. Substantial underrecognition and undertreatment of these disorders have been demonstrated. There is no evidence that the prevalence rates of anxiety disorders have changed in the past years. In cross-cultural comparisons, prevalence rates are highly variable. It is more likely that this heterogeneity is due to diffe...

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Anxiety and depressive disorders in elderly with chronic dizziness of vestibular origin

Sat, 10 Oct 2015 00:00:00 +0100

Conclusion Aged patients with chronic dizziness had high prevalence of some mental disorders. (Source: Brazilian Journal of Otorhinolaryngology)



The attributable burden of panic disorder in the impairment of quality of life in a national survey in Italy

Thu, 08 Oct 2015 00:00:00 +0100

Conclusions: The burden attributable to the impairment of QoL following a lifetime diagnosis of PD was found to be not so great compared to the impairment caused by Major Depressive Disorder (MDD) or neurological conditions. The comorbidity of PD with AP worsens QoL significantly. (Source: International Journal of Social Psychiatry)



Panic disorder and agoraphobia: A direct comparison of their multivariate comorbidity patterns

Mon, 05 Oct 2015 00:00:00 +0100

Scientific debate has long surrounded whether agoraphobia is a severe consequence of panic disorder or a frequently comorbid diagnosis. Multivariate comorbidity investigations typically treat these diagnoses as fungible in structural models, assuming both are manifestations of the fear-subfactor in the internalizing–externalizing model. No studies have directly compared these disorders' multivariate associations, which could clarify their conceptualization in classification and comorbidity research. (Source: Journal of Affective Disorders)



Panic disorder and agoraphobia:A direct comparison of their multivariate comorbidity patterns

Mon, 05 Oct 2015 00:00:00 +0100

Scientific debate has long surrounded whether agoraphobia is a severe consequence of panic disorder or a frequently comorbid diagnosis. Multivariate comorbidity investigations typically treat these diagnoses as fungible in structural models, assuming both are manifestations of the fear-subfactor in the internalizing-externalizing model. No studies have directly compared these disorders’ multivariate associations, which could clarify their conceptualization in classification and comorbidity research. (Source: Journal of Affective Disorders)



Classification of anxiety disorders comorbid with major depression: common or distinct influences on risk?

Tue, 29 Sep 2015 00:00:00 +0100

ConclusionsRisk for MD resulting from environmental and psychosocial factors may also predispose individuals to GAD, and less consistently, other anxiety disorders. Presentations of MD with certain phobias display distinguishably different patterns of risk, however, and are therefore likely qualitatively distinct. (Source: Depression and Anxiety)

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Chronotype associations with depression and anxiety disorders in a large cohort study

Mon, 14 Sep 2015 00:00:00 +0100

ConclusionsOur findings show a clear association between MDD and late chronotype (being an evening type), after controlling for a range of pertinent factors. A late chronotype is therefore associated with a current status of MDD and deserves the relevant clinical attention when considering treatments. (Source: Depression and Anxiety)



Living with Panic Attacks

Thu, 03 Sep 2015 17:45:28 +0100

You’re sitting in your car trying to will yourself to walk into the grocery store. Anxiety washes over you. You’re cold and hot at the same time with sweat trickling down your back, hair standing on your arms. You finally get out of your car. But as you enter the store, you feel wobbly and like you’re going to pass out. The fluorescent lighting seems especially stifling. The wide aisles, oddly enough, feel claustrophobic. Your breath feels finite, like a balloon floating up to the sky, which you can’t catch. In fact, at times you feel like you’re floating along with the balloon. At times you feel like Edvard Munch’s famous painting “The Scream,” your whole body shrieking. This happens in other places, too. Sometimes, it happens when you’re at the mall or somewhere new. So...



Association of Human microRNAs miR-22 and miR-491 polymorphisms with panic disorder with or without agoraphobia in a Korean population

Wed, 02 Sep 2015 00:00:00 +0100

The possible involvement of microRNAs (miRNA) in psychiatric disorders has been recently recognized. Several miRNA polymorphisms have been found to be associated with panic disorder (PD) in European populations. However, the association of miRNA polymorphisms on PD has not been reported in Asian populations. We evaluated the effect of miR-22 and miR-491 polymorphisms on susceptibility to PD in a Korean population. (Source: Journal of Affective Disorders)



Tinnitus and anxiety disorders: a review.

Wed, 02 Sep 2015 00:00:00 +0100

CONCLUSION: Comorbidity is high and screening for and treatment of anxiety disorders is recommended in moderate to severe tinnitus, as, given the overlap in the structural and functional brain circuitries involved, theoretically, their management could improve (subjective) levels of tinnitus although further empirical research on this topic is required. PMID: 26342399 [PubMed - as supplied by publisher] (Source: Hearing Research)



P.4.b.001 Baseline heartbeat perception accuracy and short-term outcome of brief cognitive-behaviour therapy for panic disorder with agoraphobia

Tue, 01 Sep 2015 00:00:00 +0100

(Source: European Neuropsychopharmacology)

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Moderators of intensive cognitive behavioral therapy for adolescent panic disorder: the roles of fear and avoidance

Tue, 01 Sep 2015 00:00:00 +0100

ConclusionsFindings help clarify which adolescents suffering with PDA may benefit most from an intensive treatment format. (Source: Child and Adolescent Mental Health)



The Mile Long Bookshelf's Amber Kirk-Ford starts crowdfunding campaign to fund A levels

Tue, 18 Aug 2015 16:28:29 +0100

Agoraphobic book blogger Amber Kirk-Ford, 16, from Norfolk, has already received over £3,000 needed to meet her target of £4,500 to pay for tuition, examination and book fees at InterHigh. (Source: the Mail online | Health)



Scared Sick: Living With Emetophobia

Tue, 18 Aug 2015 12:14:55 +0100

I'm approaching the age of 30. I have a fiancé, a dog, a growing career, a passport full of stamps and a healthy social life. Oh, and I have emetophobia. My emetophobia, which is a fear of vomit, often feels like it controls my life. Phobias affect 8.7 percent of people in America, and here in Australia, figures are similar. I'm one of the ones who drew the short straw. My fiancé and best friends fall in the lucky group -- they are part of the majority who don't suffer with a debilitating disorder. They are sympathetic to my irrational fears, but they can't empathize because try as they might, they don't understand what it's like to have your thoughts consumed by fear every. single. day. Let me paint a picture. I've suffered from this affliction as long as I can remember. As a chil...



Mental health and alcohol problems among Estonian cleanup workers 24 years after the Chernobyl accident

Tue, 11 Aug 2015 00:00:00 +0100

Conclusion The toll of cleanup work was evident 24 years after the Chernobyl accident among Estonian cleanup workers indicating the need for focused mental health interventions. (Source: Social Psychiatry and Psychiatric Epidemiology)

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Agoraphobia and Melancholia: Thoughts on Milrod's "Emptiness in Agoraphobia Patients".

Tue, 11 Aug 2015 00:00:00 +0100

Agoraphobia and Melancholia: Thoughts on Milrod's "Emptiness in Agoraphobia Patients". J Am Psychoanal Assoc. 2015 Aug 11; Authors: Yates S Abstract Milrod (2007) identifies persistent emptiness in agoraphobic patients whose symptoms of anxiety and avoidance have remitted. To this important identification, a number of critical considerations may be raised regarding the meanings of emptiness in the psychoanalytic clinic. Milrod's admonishment to distinguish between an emptiness that indicates a deficit in the structure and stability of self-representation, and an emptiness that is strictly defensive, is a case in point. While much of the literature supports an interpretation of emptiness as a defense against overwhelming rage, these patients' assertions and experiences ...



Chronic Low Back Pain: Perception and Coping With Pain in the Presence of Psychiatric Comorbidity

Sat, 01 Aug 2015 05:00:00 +0100

Abstract: This retrospective study investigated the influence of psychiatric comorbidity on pain perception and coping with pain in tertiary pain clinic patients, 427 treated for chronic low back pain (CLBP) and 629 for other forms of chronic pain (CG). No differences in psychosomatic dimensions were found between the two groups, but Italian Pain Questionnaire dimensions and intensity scores (t = 7.35; p < 0.0001) were higher in CLBP than in CG subjects. According to the Mini-International Neuropsychiatric Interview, CLBP patients also had a higher prevalence of lifetime major depressive episodes (χ2 = 4.96; p < 0.05), dysthymic disorder (χ2 = 4.64; p < 0.05), suicide risk (χ2 = 10.43; p < 0.01), and agoraphobia (χ2 = 6.31; p < 0.05) than CG patients did. The Multidimensional Pain Inve...



Information Omitted From Analyses

Sat, 01 Aug 2015 00:00:00 +0100

This article was corrected online. (Source: JAMA Psychiatry)



Anxiety Disorders Affect 4.3 Million Working US Adults

Tue, 28 Jul 2015 00:00:00 +0100

This report was based on data from SAMHSA’s 2008-2012 National Survey on Drug Use and Health, derived from responses from 67 500 people 12 years and older in the United States who took part in the SAMHSA survey between 2008 and 2012 (http://1.usa.gov/1Rtcf03). Anxiety disorders included obsessive-compulsive disorder, specific phobia, social phobia, panic disorder with and without agoraphobia, agoraphobia without a history of panic disorder, posttraumatic stress disorder, and generalized anxiety disorder. (Source: JAMA)



Chef too scared to leave the house due to Moebius Syndrome cured of agoraphobia

Tue, 21 Jul 2015 10:21:34 +0100

Richard Savage, 43, from Birmingham has Moebius syndrome, a genetic condition causing facial paralysis. He suffered such abuse he became agoraphobic and stayed inside for two years. (Source: the Mail online | Health)

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Chef too scared to leave the house due to Moebius Syndrome cured

Mon, 20 Jul 2015 13:52:53 +0100

Richard Savage, 43, from Birmingham has Moebius syndrome, a genetic condition causing facial paralysis. He suffered such abuse he became agoraphobic and stayed inside for two years. (Source: the Mail online | Health)



The combined use of virtual reality exposure in the treatment of agoraphobia.

Wed, 01 Jul 2015 00:00:00 +0100

CONCLUSIONS: Treatments combining psychopharmacological and psychological therapy showed greater efficacy. Although the use of new technologies led to greater improvement, treatment adherence problems still remain. PMID: 26150057 [PubMed - in process] (Source: Actas Espanolas de Psiquiatria)



Interactions of borderline personality disorder and anxiety disorders over 10 years.

Sat, 27 Jun 2015 16:26:04 +0100

CONCLUSIONS: BPD negatively affects the course of GAD, social phobia, and PTSD. In contrast, the anxiety disorders, aside from PTSD, had little effect on BPD course. For GAD and social phobia, whose course BPD unidirectionally influences, we suggest prioritizing treatment for BPD, whereas BPD should be treated concurrently with panic disorders, OCD, or PTSD. We discuss state/trait issues in the context of our findings. PMID: 26114336 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)



Psychotherapies for panic disorder: a tale of two sites.

Sat, 27 Jun 2015 16:26:04 +0100

CONCLUSIONS: All treatments substantially improved panic disorder with or without agoraphobia, but patients, particularly the most severely ill, found ART less acceptable. CBT showed the most consistent performance across sites; however, the results for PFPP showed the promise of psychodynamic psychotherapy for this disorder. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00353470. PMID: 26115481 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)



Quality of life and risk of psychiatric disorders among regular users of alcohol, nicotine, and cannabis: An analysis of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC)

Tue, 23 Jun 2015 00:00:00 +0100

Publication date: July–August 2015 Source:Journal of Psychiatric Research, Volumes 66–67 Author(s): Jesse R. Cougle , Jahn K. Hakes , Richard J. Macatee , Jesus Chavarria , Michael J. Zvolensky Research is limited on the effects of regular substance use on mental health-related outcomes. We used a large nationally representative survey to examine current and future quality of life and risk of psychiatric disorders among past-year regular (weekly) users of alcohol, nicotine, and cannabis. Data on psychiatric disorders and quality of life from two waves (Wave 1 N = 43,093, Wave 2 N = 34,653) of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) were used to test study aims. In cross-sectional analyses, regular nicotine and cannabis use were associated ...

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Working at the frontiers of nothingness: Homicidal transference, fear of death, and the body.

Mon, 22 Jun 2015 00:00:00 +0100

The author presents some aspects of the psychoanalytic treatment of a young man diagnosed with schizophrenia, showing marked agoraphobic symptoms, fear of falling into a boundless void, and persecutory fantasies of killing his mother. After a complete remission of the symptoms, the final phase of the analysis was characterized by an explosion of paranoia and a dramatic homicidal transference. The mental integration of the body and the working through of death anxieties proved decisive in overcoming the patient’s critical body–mind dissociation, which had paralyzed his mental functioning and analytic evolution. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: Psychoanalytic Psychology)



Coping strategies and distress reduction in psychological well-being? A structural equation modelling analysis using a national population sample.

Sat, 20 Jun 2015 05:02:05 +0100

CONCLUSIONS: Our findings have practical implications for public psychiatric disease intervention and mental health promotion. As previously noted positive/adaptive coping increased the level of PWB, whereas negative/maladaptive coping was positively related to distress and negatively related to PWB. Distress decreased the level of PWB. Our findings identified major correlates of PWB in both the general population and population subgroups. Our results provide evidence for the differential use of intervention tactics among different target audiences. In order to improve the mental health of the general population public mental health promotion should focus on strategies that reduce negative coping at a population level, whereas clinicians treating individual clients should make the reductio...



Long-term effects of mental disorders on educational attainment in the National Comorbidity Survey ten-year follow-up

Wed, 17 Jun 2015 00:00:00 +0100

Conclusions Expanding access to mental health services for youth might have a net positive societal value by helping to prevent some of these adverse educational outcomes. (Source: Social Psychiatry and Psychiatric Epidemiology)



Psychiatric and substance-use comorbidities associated with lifetime crack cocaine use in young adults in the general population - Narvaez JC, Jansen K, Pinheiro RT, Kapczinski F, Silva RA, Pechansky F, Magalhães PV.

Tue, 16 Jun 2015 19:21:33 +0100

OBJECTIVE: To assess the association between lifetime crack cocaine use and psychiatric (post-traumatic stress disorder, current depression, current dysthymia, generalized anxiety disorder, panic disorder with agoraphobia, social phobia, as well as SRQ sco... (Source: SafetyLit: All (Unduplicated))



Frontal cortex absolute beta power measurement in panic disorder with agoraphobia Patients

Tue, 09 Jun 2015 00:00:00 +0100

The objective of this study was to measure frontal absolute beta-power (ABP) with qEEG in panic disorder and agoraphobia (PDA) patients compared to healthy controls. (Source: Journal of Affective Disorders)

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Separating depressive comorbidity from panic disorder: A combined functional magnetic resonance imaging and machine learning approach

Sat, 06 Jun 2015 00:00:00 +0100

Depression is frequent in panic disorder (PD); yet, little is known about its influence on the neural substrates of PD. Difficulties in fear inhibition during safety signal processing has been reported as a pathophysiological feature of PD that is attenuated by depression. We investigated the impact of comorbid depression in PD with agoraphobia (AG) on the neural correlates of fear conditioning and the potential of machine learning to predict comorbidity status on the individual patient level based on neural characteristics. (Source: Journal of Affective Disorders)



Morbidly obese mother too scared to leave the house loses FIVE STONE by walking after her

Tue, 02 Jun 2015 23:43:44 +0100

Size 20 Sonya Brennan, from Catford in South London, who now weighs 10 stone, piled on the pounds snacking on biscuits and crisps after developing agoraphobia, a fear of going outside. (Source: the Mail online | Health)



Can you cure a phobia in three days?

Mon, 01 Jun 2015 06:05:18 +0100

Psychologist Richard Reid took on the challenge in a new Sky 1 programme, Fright Club (Source: Telegraph Health)



Are there subtypes of panic disorder? An interpersonal perspective.

Mon, 01 Jun 2015 00:00:00 +0100

Conclusions: Empirically derived interpersonal clusters in PD provide clinically useful and nonredundant information about individuals with PD. (PsycINFO Database Record (c) 2015 APA, all rights reserved) (Source: Journal of Consulting and Clinical Psychology)



A synopsis of original research projects published in scientific database in the Russian Federation.

Sun, 31 May 2015 04:30:03 +0100

Authors: Smirnova D, Pavlichenko A, Karpenko O, Schmeleva L, Morozov P Abstract The article describes the current state of scientific publications in the field of psychiatry in the Russian Federation. Issues of academic dissertations, lack of access to recent Russian language research in foreign databases, and recent reforms in the Ministry of Education and Science for overcoming these limitations are discussed in detail. Four exemplary dissertation studies published in Russian language are summarized. The first research examines the contribution of patient's verbal behavior to the reliable diagnosis of mild depression, identifying objective signs for distinguishing it from normal sadness; the mood component influenced the whole mental status and was represented in both structure a...

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Depression, anxiety and major adverse cardiovascular and cerebrovascular events in patients following coronary artery bypass graft surgery: a five year longitudinal cohort study

Mon, 25 May 2015 14:20:46 +0100

Conclusions: Generalized anxiety disorder was significantly associated with MACCE at follow-up after CABG surgery. The findings encourage further research pertaining to generalized anxiety disorder, and theoretical conceptualizations of depression, general distress and anxiety in persons undergoing CABG surgery. (Source: BioMed Central)



New Research on Anxiety Disorders in the Elderly and an Update on Evidence-Based Treatments

Sat, 16 May 2015 00:00:00 +0100

Abstract Anxiety disorders are frequently encountered in the elderly, but they are largely undetected and untreated. Epidemiological studies indicate a prevalence ranging from 1.2 to 15 %. With the exception of generalized anxiety disorder and agoraphobia, which can often start in late life, most anxiety disorders in older patients are chronic and have their onset earlier in life. Anxiety disorders are an often unrecognized cause of distress, disability, and mortality risk in older adults, and they have been associated with cardiovascular disease, stroke, and cognitive decline. The mechanisms of anxiety in older adults differ from that in younger adults due to age-related neuropathology, as well as the loss and isolation so prominent in late life. Our review intends to provide a...



Mindfulness-Based Therapy in Adults with an Autism Spectrum Disorder: Do Treatment Effects Last?

Fri, 15 May 2015 17:29:19 +0100

In conclusion, MBT-AS appears to be an effective method for reducing a variety of symptoms, and treatment gains remain stable over the longer term. (Source: Mindfulness)



First Times and Anxiety

Tue, 12 May 2015 17:45:55 +0100

How do you understand when anxiety is finally over? I’ve asked myself this question many times. Let me be frank: I have no answer to that. Nevertheless, a few months ago I casually stumbled upon the following quote and I believe I couldn’t have found a better way to describe my feelings: Once the storm is over you won’t remember how you made it through, how you managed to survive. You won’t even be sure, in fact, whether the storm is really over. But one thing is certain. When you come out of the storm you won’t be the same person who walked in. That’s what this storm’s all about. — Haruki Murakami, Kafka on the Shore This is exactly what it feels like to me. Fourteen months after everything began, almost a year after I hit my lowest point, I still have no idea whether ...



Metabolic decoupling in daily life in patients with panic disorder and agoraphobia

Sun, 10 May 2015 00:00:00 +0100

Publication date: Available online 9 May 2015 Source:Journal of Psychiatric Research Author(s): Monique C. Pfaltz , Vitaliy Kolodyazhniy , Jens Blechert , Jürgen Margraf , Paul Grossman , Frank H. Wilhelm Various studies have assessed autonomic and respiratory underpinnings of panic attacks, yet the psychophysiological functioning of panic disorder (PD) patients has rarely been examined under naturalistic conditions at times when acute attacks were not reported. We hypothesized that emotional activation in daily life causes physiologically demonstrable deviations from efficient metabolic regulation in PD patients. Metabolic coupling was estimated as within-individual correlations between heart rate (HR) and indices of metabolic activity, i.e., physical activity (measured by 3-axial acce...



Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders.

Sun, 10 May 2015 00:00:00 +0100

CONCLUSIONS: This review found no evidence of a difference between DCS augmentation of cognitive and behavioural therapies and placebo augmentation of cognitive and behavioural therapies for treating anxiety and related disorders in children, adolescents and adults. These findings are based on low quality evidence, small sample sizes and incomplete data for clinical response, which precludes us from drawing conclusions on the use of DCS augmentation of cognitive and behavioural therapies at this stage.Further research is necessary to assess the use of DCS compared with placebo augmentation of cognitive and behavioural therapies, and determine mechanisms of action as well as magnitude of effect in anxiety and related disorders. More trials could provide a more precise estimate of treatment ...



The impact of emotional distress on motor blocks and festination in Parkinson's disease.

Fri, 01 May 2015 23:12:03 +0100

Authors: Starkstein S, Dragovic M, Brockman S, Wilson M, Bruno V, Merello M Abstract Recent studies suggest that depression and anxiety in patients with Parkinson's disease may predispose them to freezing. Although festination is also frequent, the association with emotional disorders has not been examined. The aim of the authors was to clarify the association between freezing and festination with anxiety, depressive disorders, and emotional distress. The authors examined a consecutive series of 95 patients with Parkinson's disease using comprehensive psychiatric assessments and a new instrument specifically designed to assess the severity of freezing, festination, and emotional distress (Motor Blocks and Festination Scale). All patients were assessed with the Motor Blocks and Fest...



Therapeutic tech company “Virtually Free” announces latest app to tackle agoraphobia

Fri, 01 May 2015 17:26:43 +0100

On Wednesday 24 September 2014, Virtually Free, a tech company which makes apps to improve mental health, is announcing its latest project, Agoraphobia Free, set for launch in the first half of 2015, and is calling out for volunteers to take part in their clinical trials which will be running for the next couple of […] (Source: ANXIETY UK News)



Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the LifeLines Cohort Study

Fri, 01 May 2015 05:00:00 +0100

Conclusions: Mood and anxiety disorders are more prevalent in individuals with FSSs, and particularly CFS, than in individuals without FSSs. However, most individuals with FSSs do not have mood or anxiety disorders. (Source: Psychosomatic Medicine)

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Distress tolerance in OCD and anxiety disorders, and its relationship with anxiety sensitivity and intolerance of uncertainty

Fri, 24 Apr 2015 00:00:00 +0100

Publication date: Available online 22 April 2015 Source:Journal of Anxiety Disorders Author(s): Judith M. Laposa , Kelsey C. Collimore , Lance L. Hawley , Neil A. Rector There is a growing interest in the role of distress tolerance (i.e., the capacity to withstand negative emotions) in the onset and maintenance of anxiety. However, both empirical and theoretical knowledge regarding the role of distress tolerance in the anxiety disorders is relatively under examined. Accumulating evidence supports the relationship between difficulties tolerating distress and anxiety in nonclinical populations; however, very few studies have investigated distress tolerance in participants with diagnosed anxiety disorders. Individuals with social anxiety disorder (SAD), generalized anxiety disorder (GAD), p...



Suicidality in Australian Vietnam veterans and their partners

Fri, 24 Apr 2015 00:00:00 +0100

Publication date: Available online 13 April 2015 Source:Journal of Psychiatric Research Author(s): Brian I. O'Toole , Tammy Orreal-Scarborough , Deborah Johnston , Stanley V. Catts , Sue Outram Lifetime suicidality was assessed in a cohort of 448 ageing Australian Vietnam veterans and 237 female partners during in-person structured psychiatric interviews that permitted direct comparison with age-sex matched Australian population statistics. Relative risks for suicidal ideation, planning and attempts were 7.9, 9.7 and 13.8 times higher for veterans compared with the Australian population and for partners were 6.2, 3.5 and 6.0 times higher. Odds ratios between psychiatric diagnoses and suicidality were computed using multivariate logistic regression, and suicidality severity scores were as...



Bridges, Planes and Panic Attacks: Getting Over Fear

Fri, 17 Apr 2015 20:09:57 +0100

I'm not sure when I first realized I was afraid of flying but it wasn't long after I entered college. I'd worry for weeks and weeks as the departure date would get closer and closer. I distinctly remember having diarrhea EVERY TIME I'd arrive at the airport. I also remember seriously thinking "we're all going to die" when we'd board the plane and I'd wonder why other people in line didn't seem more concerned about this possibility. (The way my fearful mind worked, it actually seemed more like a probability.) And once I'd get to my destination I'd have to worry about getting back home the whole time I was away! Even when I wasn't flying, I'd have nightmares about it. I'd wake up so relieved to realize I didn't have to get on a plane. I even remember feeling nauseous driving near airports ...



Predictors of short- and long-term avoidance in completers of inpatient group interventions for agoraphobia

Fri, 10 Apr 2015 00:00:00 +0100

In this study, we wished to examine predictors of short- and long-term avoidance after inpatient group interventions for agoraphobia. (Source: Journal of Affective Disorders)



An admixture analysis of age of onset in agoraphobia

Tue, 07 Apr 2015 00:00:00 +0100

Age of onset is an important epidemiological indicator in characterizing disorders' subtypes according to demographic, clinical and psychosocial determinants. While investigated in various psychiatric conditions, age of onset and related characteristics in agoraphobia have yet to be examined. In light of the new diagnostic status in the DSM-5 edition of agoraphobia as independent from panic disorder, research on agoraphobia as a stand-alone disorder is needed. (Source: Journal of Affective Disorders)

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Panic Disorder and Agoraphobia [Reviews]

Wed, 01 Apr 2015 00:00:00 +0100

(Source: Psychiatric Bulletin)



MicroRNA hsa‐miR‐4717‐5p regulates RGS2 and may be a risk factor for anxiety‐related traits

Wed, 01 Apr 2015 00:00:00 +0100

Regulator of G‐protein Signaling 2 (RGS2) is a key regulator of G‐protein‐coupled signaling pathways involved in fear and anxiety. Data from rodent models and genetic analysis of anxiety‐related traits and disorders in humans suggest down‐regulation of RGS2 expression to be a risk factor for anxiety. Here we investigated, whether genetic variation in microRNAs mediating posttranscriptional down‐regulation of RGS2 may be a risk factor for anxiety as well. 75 microRNAs predicted to regulate RGS2 were identified by four bioinformatic algorithms and validated experimentally by luciferase reporter gene assays. Specificity was confirmed for six microRNAs (hsa‐miR‐1271‐5p, hsa‐miR‐22‐3p, hsa‐miR‐3591‐3p, hsa‐miR‐377‐3p, hsa‐miR‐4717‐5p, hsa‐miR‐96‐5...



Clinical consequences of the revised dsm‐5 definition of agoraphobia in treatment‐seeking anxious youth

Wed, 01 Apr 2015 00:00:00 +0100

ConclusionsA substantial proportion of impaired youth with considerable agoraphobic symptom presentations have been left without a specified anxiety diagnosis by the DSM‐5, which may affect their ability to receive and/or get coverage for services and their representation in treatment evaluations. Future DSM iterations may do well to include a “circumscribed” agoraphobia specifier that would characterize presentations of fear or anxiety about multiple situations, but that do not span across at least two distinct situational domains. (Source: Depression and Anxiety)



The POSE study - panic control treatment versus panic-focused psychodynamic psychotherapy under randomized and self-selection conditions: study protocol for a randomized controlled trial

Tue, 31 Mar 2015 00:00:00 +0100

DiscussionCognitive behavioral and psychodynamic therapies are both evidence-based approaches that are routinely offered to panic disordered patients in Sweden. However, little is known about the relative effectiveness of these two approaches for panic/agoraphobia, work-related disability and healthcare utilization over the longer term. The current trial (POSE) also addresses the important but understudied issue of whether patient preference for a particular psychotherapeutic approach moderates outcome.Trial registrationClinicalTrials.gov NCT01606592 (registered 19 March 2012). (Source: Trials)



The attributable burden of panic disorder in the impairment of quality of life in a national survey in Italy.

Thu, 12 Mar 2015 00:00:00 +0100

CONCLUSIONS: The burden attributable to the impairment of QoL following a lifetime diagnosis of PD was found to be not so great compared to the impairment caused by Major Depressive Disorder (MDD) or neurological conditions. The comorbidity of PD with AP worsens QoL significantly. PMID: 25770204 [PubMed - as supplied by publisher] (Source: The International Journal of Social Psychiatry)

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Extraversion and psychopathology: A facet-level analysis.

Mon, 09 Mar 2015 00:00:00 +0100

The goal of this study was to explicate how the lower order facets of extraversion are related to psychopathology. We used a “bottom-up” approach in which specific extraversion scales from 3 comprehensive personality inventories were used to model these facets as latent factors. We collected both self-report and interview measures of a broad range of psychopathology from a large community sample. Replicating previous findings using a similar approach (Naragon-Gainey & Watson, 2014; Naragon-Gainey, Watson, & Markon, 2009), structural analyses yielded four factors: Positive Emotionality, Sociability, Assertiveness, and Experience Seeking. Scores on these latent dimensions were related to psychopathology in correlational analyses and in two sets of regressions (the first series used the f...



Therapist-supported Internet cognitive behavioural therapy for anxiety disorders in adults.

Thu, 05 Mar 2015 00:00:00 +0100

CONCLUSIONS: Therapist-supported ICBT appears to be an efficacious treatment for anxiety in adults. The evidence comparing therapist-supported ICBT to waiting list, attention, information, or online discussion group only control was low to moderate quality, the evidence comparing therapist-supported ICBT to unguided ICBT was low to very low quality, and comparisons of therapist-supported ICBT to face-to-face CBT was low to moderate quality. Further research is needed to better define and measure any potential harms resulting from treatment. These findings suggest that therapist-supported ICBT is more efficacious than a waiting list, attention, information, or online discussion group only control, and that there may not be a significant difference in outcome between unguided CBT and therapi...



RGS2 ggenetic variation: Association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety

Wed, 04 Mar 2015 00:00:00 +0100

Accumulating evidence from mouse models points to the G protein‐coupled receptor RGS2 (regulator of G‐protein signaling 2) as a promising candidate gene for anxiety in humans. Recently, RGS2 polymorphisms were found to be associated with various anxiety disorders, e.g., rs4606 with panic disorder (PD), but other findings have been negative or inconsistent concerning the respective risk allele. To further examine the role of RGS2 polymorphisms in the pathogenesis of PD, we genotyped rs4606 and five additional RGS2 tag single nucleotide polymorphisms (SNPs; rs16834831, rs10801153, rs16829458, rs1342809, rs1890397) in two independent PD samples, comprising 531 matched case/control pairs. The functional SNP rs4606 was nominally associated with PD when both samples were combined. The upstre...



RGS2 genetic variation: Association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety

Wed, 04 Mar 2015 00:00:00 +0100

Accumulating evidence from mouse models points to the G protein‐coupled receptor RGS2 (regulator of G‐protein signaling 2) as a promising candidate gene for anxiety in humans. Recently, RGS2 polymorphisms were found to be associated with various anxiety disorders, e.g., rs4606 with panic disorder (PD), but other findings have been negative or inconsistent concerning the respective risk allele. To further examine the role of RGS2 polymorphisms in the pathogenesis of PD, we genotyped rs4606 and five additional RGS2 tag single nucleotide polymorphisms (SNPs; rs16834831, rs10801153, rs16829458, rs1342809, rs1890397) in two independent PD samples, comprising 531 matched case/control pairs. The functional SNP rs4606 was nominally associated with PD when both samples were combined. The upstre...



Co-occurring Psychiatric Disorders in Preschool and Elementary School-Aged Children with Autism Spectrum Disorder.

Wed, 04 Mar 2015 00:00:00 +0100

Authors: Salazar F, Baird G, Chandler S, Tseng E, O'sullivan T, Howlin P, Pickles A, Simonoff E Abstract We employed a clinical sample of young children with ASD, with and without intellectual disability, to determine the rate and type of psychiatric disorders and possible association with risk factors. We assessed 101 children (57 males, 44 females) aged 4.5-9.8 years. 90.5 % of the sample met the criteria. Most common diagnoses were: generalized anxiety disorder (66.5 %), specific phobias (52.7 %) and attention deficit hyperactivity disorder (59.1 %). Boys were more likely to have oppositional defiant disorder (OR 3.9). Higher IQ was associated with anxiety disorders (OR 2.9) and older age with agoraphobia (OR 5.8). Night terrors was associated with parental psychological di...

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Beyond Negative Affectivity: A Hierarchical Model of Global and Transdiagnostic Vulnerabilities for Emotional Disorders.

Tue, 03 Mar 2015 00:00:00 +0100

Conclusions: This study demonstrates the importance of both general factors that link disorders together and semi-specific transdiagnostic factors partially explaining their heterogeneity. Including these mid-level factors in hierarchical models of psychopathology can help account for additional variance and help to clarify the relationship between disorder constructs and NA. PMID: 25734894 [PubMed - as supplied by publisher] (Source: Cognitive Behaviour Therapy)



Does low coping efficacy mediate the association between negative life events and incident psychopathology? A prospective-longitudinal community study among adolescents and young adults.

Sat, 28 Feb 2015 09:40:04 +0100

Conclusions. Our findings suggest that NLE and low perceived CE elevate the risk for various incident mental disorders and that low CE partially mediates the association between NLE and incident depression. Subjects with NLE might thus profit from targeted early interventions strengthening CE to prevent the onset of depression. PMID: 25712151 [PubMed - as supplied by publisher] (Source: Epidemiology and Psychiatric Sciences)



Social Anxiety Disorder and Agoraphobia in Dermatology Patients; Two Cases and a Review of the Literature.

Fri, 27 Feb 2015 00:00:00 +0100

Authors: Marshall C, Bewley A Abstract Abstract is missing (Short communication). PMID: 25721467 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)



Treatment of Agoraphobia in a Pregnant Woman: A Combination of Exposure and Acceptance and Commitment Therapy

Wed, 25 Feb 2015 00:00:00 +0100

A combination of exposure therapy techniques and Acceptance and Commitment Therapy (ACT) strategies were used to treat a 23-year-old pregnant female who was housebound due to symptoms of agoraphobia. The client in this case study had not left her family home in 10 months when she sought treatment for her anxiety. The client was successfully treated over a year, such that she was able to receive prenatal care at an obstetrician’s office and to deliver her infant at a hospital. Neither the client nor her fetus suffered any complications due to treatment. Post-treatment and 1-year follow-up data indicated that the client continued to show significant functional improvements following the birth of her child. Recommendations for integrating ACT strategies into exposure therapy for severe ...



Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.

Mon, 23 Feb 2015 00:00:00 +0100

Conclusions. Examining just a few candidate genes for their potential roles in internalizing phenotypes, we found moderate support for the shared effects of several polymorphisms. These findings highlight the richness and complexity by which genes potentially contribute to psychopathology via pleiotropy, moderation by stress, and mediation by temperament. PMID: 25702797 [PubMed - as supplied by publisher] (Source: Psychological Medicine)

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Treating Treatment-Resistant Patients with Panic Disorder and Agoraphobia Using Psychotherapy: A Randomized Controlled Switching Trial

Fri, 20 Feb 2015 20:03:03 +0100

Conclusions: Despite a clinically challenging sample and brief treatment administered by novice therapists, patients who received ACT reported significantly greater changes in functioning and symptomatology than those on the waiting list, with medium-to-large effect sizes that were maintained for at least 6 months. These proof-of-principle data suggest that ACT is a viable treatment option for treatment-resistant PD/A patients. Further work on switching to psychotherapy for nonresponders is clearly needed.Psychother Psychosom 2015;84:100-109 (Source: Psychotherapy and Psychosomatics)



Persistent HIV-related stigma among an outpatient US clinic population

Thu, 19 Feb 2015 00:00:00 +0100

Despite advancements in the public’s understanding of HIV infection, felt stigma towards individuals living with HIV persists. Stigma has been associated with adverse health outcomes, including poor adherence to care, and increased participation in HIV transmission risk behaviours. We evaluated the level of felt stigma and its relationship to other psychosocial and medical factors among a sample of 201 individuals with HIV engaged in care. The overall mean stigma score, as measured by the Reece Stigma Scale, was 21.7 (SD 8.7). In univariate analysis, felt stigma scores were higher among women, African Americans, younger participants, and individuals with less education. Higher felt stigma scores were also found among individuals who reported having fair to poor overall health, modera...



Psychiatric disorders in 130 survivors of childhood cancer: Preliminary results of a semi‐standardized interview

Sat, 14 Feb 2015 00:00:00 +0100

ConclusionsResults were consistent between the self‐questionnaire and MINI interview responses, though time may have biased memory. Vulnerability to and high risk for developing DSM‐IV Axis 1 psychiatric disorders of childhood cancer survivors can persist long after diagnosis and treatment. Thus, systematic and general psychological screening of survivors may facilitate long‐term psychological restoration. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)



Major Depressive and Anxiety Disorders in Visually Impaired Older Adults [Low Vision]

Thu, 05 Feb 2015 00:00:00 +0100

Conclusions. This study shows that depression and anxiety are major public health problems in visually impaired older adults. Research on psychotherapeutic and psychopharmacologic interventions to improve depression and anxiety in this population is warranted. (http://www.trialregister.nl number, NTR3296.) (Source: Investigative Ophthalmology)



How the menopause can drive women MAD

Mon, 26 Jan 2015 09:24:24 +0100

Christina Roberts (left) suffered from anxiety and almost ended up agoraphobic. Samantha Cole (centre) started to feel really down and victimised. Jo Gordon (right) suffered from rage and frustration. (Source: the Mail online | Health)

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