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MedWorm: Bipolar News



MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Bipolar



Last Build Date: Mon, 19 Feb 2018 18:29:05 +0100

 



Childhood sexual abuse and suicidal ideation among bipolar patients: existential but not religious well-being as a protective factor - Lamis DA, Kapoor S, Evans APB.

Sat, 17 Feb 2018 10:36:27 +0100

Individuals diagnosed with bipolar disorder (BD) are at an increased risk of Suicidal ideation, attempts, and death. Moreover, a strong association exists between childhood sexual abuse (CSA) and suicidal ideation among individuals with BD. Yet growing evi... (Source: SafetyLit)

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Symptom profile of psychiatric patients with psychosis or psychotic mood disorder in prison - van Beek J, Vuijk PJ, Harte JM, Scherder EJA.

Sat, 17 Feb 2018 10:36:27 +0100

There is evidence that psychiatric patients with psychotic or manic disorders who are incarcerated suffer from the same symptoms as psychiatric patients who are treated in the community. There are also indications that their symptoms might be more severe. ... (Source: SafetyLit)



Book Review: Insane Consequences

Wed, 14 Feb 2018 03:13:15 +0100

I have read Insane Consequences: How the Mental Health Industry Fails the Mentally Ill a couple of times and am still contemplating it. It also inspired me to research further into how we treat the seriously mentally ill in America. In the book, author DJ Jaffe takes on what he calls the “mental health industry,” and I think that is a fair characterization. He is not the only writer to use the phrase, and he confronts that industry with a voice that reminds me of a prosecuting attorney on a mission. Jaffe became involved in the mental health system in the 1980s when his wife’s 18 year old sister, Lynn, came to New York from Wisconsin to live with them. Lynn had been a high performing high school student who began to have behavioral issues with her Hungarian immigrant mom,...



Psychiatric illnesses share similar gene activity

Tue, 13 Feb 2018 09:48:40 +0100

At least three neuropsychiatric disorders -- autism, schizophrenia and bipolar disorder -- appear to share similar patterns of gene activity, a new study suggests. (Source: CNN.com - Health)



Could football have caused Johnny Manziel's bipolar?

Mon, 12 Feb 2018 22:04:31 +0100

Manziel, 25, disclosed his diagnosis in an interview with Good Morning America on Monday, after years of controversy involving alcoholism, drug-taking and domestic violence allegations. (Source: the Mail online | Health)

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Affective temperaments play an important role in the relationship between child abuse and the diagnosis of bipolar disorder - Toda H, Inoue T, Tanichi M, Saito T, Nakagawa S, Masuya J, Tanabe H, Yoshino A, Kusumi I.

Fri, 09 Feb 2018 14:42:25 +0100

This study investigated how multiple factors, including child abuse, adult life events, and affecti... (Source: SafetyLit)



Major Psychiatric Disorders Have More In Common Than We Thought, Study Finds

Thu, 08 Feb 2018 22:34:43 +0100

Understanding the molecular basis of major disorders such as autism, schizophrenia and bipolar is hopeful, because it could help in developing better treatments for them. (Image credit: Sebastian Kaulitzki/Getty Images/Science Photo Library RF) (Source: NPR Health and Science)



Major Neurological Conditions Have More In Common Than We Thought, Study Finds

Thu, 08 Feb 2018 22:34:00 +0100

Understanding the molecular basis of major disorders such as autism, schizophrenia and bipolar disorder could help in developing better treatments. (Image credit: Sebastian Kaulitzki/Getty Images/Science Photo Library RF) (Source: NPR Health and Science)



Autism, Bipolar and Schizophrenia Share Genetic Similarities

Thu, 08 Feb 2018 20:00:00 +0100

(Source: The Doctors Lounge - Psychiatry)



Autism, schizophrenia, bipolar disorder share molecular traits, study finds

Thu, 08 Feb 2018 19:11:00 +0100

Most medical disorders have well-defined physical characteristics seen in tissues, organs and bodily fluids. Psychiatric disorders, in contrast, are not defined by such pathology, but rather by behavior.A UCLA-led study,publishedin Science, has found that autism, schizophrenia and bipolar disorder share some physical characteristics — and important differences — at the molecular level, specifically, patterns of gene expression in the brain. Gene expression is the process by which instructions in DNA are converted into a product, such as a protein.“These findings provide a molecular, pathological signature of these disorders, which is a large step forward,” said senior author Daniel Geschwind, a distinguished professor of neurology, psychiatry and human genetics and director of the ...

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Autism, Bipolar and Schizophrenia Share Genetic Similarities

Thu, 08 Feb 2018 14:02:04 +0100

THURSDAY, Feb. 8, 2018 -- By examining brain tissue, researchers say they've found similarities in certain mental illnesses, including autism and schizophrenia. Specifically, some similar patterns of gene expression were found in people with... (Source: Drugs.com - Daily MedNews)



Gene Expression Overlaps Among Psychiatric Disorders

Thu, 08 Feb 2018 14:01:00 +0100

Transcriptional profiling of post-mortem human brains reveals commonalities in the genes over- and under-expressed in schizophrenia, bipolar disorder, autism, and major depression. (Source: The Scientist)



UCLA study sheds light on genetic overlap between major psychiatric disorders

Thu, 08 Feb 2018 05:00:00 +0100

(University of California - Los Angeles) Most medical conditions are largely defined by their physical symptoms. Psychiatric illnesses, however, are largely defined by a person's behavior. A UCLA-led study challenges that distinction, identifying many shared -- and distinct -- patterns of gene expression in the brains of people with autism, schizophrenia and bipolar disorder. The data hint at potential targets that may one day lead to new treatment approaches. (Source: EurekAlert! - Social and Behavioral Science)



Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Thu, 08 Feb 2018 00:00:00 +0100

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism–based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the...



A new path into bipolar disorder comes to light

Mon, 05 Feb 2018 05:00:00 +0100

(Publicase Comunica ç ã o Cient í fica) A new article authored by an international group of researchers reveals a novel potential drug target for bipolar disorder and offers new insights into the underlying biology of this lifelong and devastating mental illness. (Source: EurekAlert! - Biology)

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Is Vaginal Rejuvenation Just Another Hollywood Fad?

Thu, 01 Feb 2018 20:31:45 +0100

It's easy to be skeptical of a procedure designed to tighten things up "down there," especially when it's been touted by celebrities like Kim Kardashian. But MD+DI recently got the low down from an obstetrics and gynecologist specialist in Lubbock, TX on a new vaginal rejuvenation device that her patients can't stop talking about. Learn about best practices in medical device design at the MD&M West Conference and Expo, February 6-8, 2018, in Anaheim, CA. Use promo code "MDDI" for 20% off conference registration and free expo access. "They've said things like, 'it's been life-changing', 'this saved my marriage', 'I'm just so happy to finally feel better'," said Jennifer Owen, MD. Unlike most of the devices marketed toward vaginal rejuvenation, the Votiva device from InMode is designed t...



3 Pervasive, Persistent Myths about Seasonal Affective Disorder

Wed, 31 Jan 2018 17:45:52 +0100

Our society tends to dismiss seasonal affective disorder (SAD). We minimize it. We misunderstand it. Oh, you just don’t like winter. And who could blame you? Winter is tough on everyone. Oh, SAD is like the winter blues, right? You get grumpy or moody because you hate the freezing cold. You’re just in a funk. It happens to a lot of people. It’s totally normal. How can you feel depressed when the air is so crisp and it’s a winter wonderland out there? We incorporate SAD into our vocabulary, flippantly using it in conversation. “Similar to someone saying “I can’t make up my mind, it’s like I’m schizophrenic,” or “Costco was out of those socks I love, I’m so depressed,” it’s tempting to trivialize the reality of SAD,” said Stephanie Smith, PsyD, a psychologi...



Brain Aging Accelerated in Schizophrenia, but Not Bipolar Disorder Brain Aging Accelerated in Schizophrenia, but Not Bipolar Disorder

Mon, 29 Jan 2018 22:14:28 +0100

The brain in people with early-stage schizophrenia, but not bipolar disorder, ages more quickly than normal, new research suggests.Reuters Health Information (Source: Medscape Today Headlines)



Science News » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor

Mon, 29 Jan 2018 18:16:18 +0100

Scientists have deciphered the molecular structure of a widely-prescribed antipsychotic docked in its key human brain receptor. The discovery may hold clues to designing better treatments for schizophrenia, bipolar disorder and other mental illnesses. (Source: National Institute of Mental Health)



ECT for Manic State in a Bipolar, OCD Teenager ECT for Manic State in a Bipolar, OCD Teenager

Mon, 29 Jan 2018 06:15:11 +0100

Should electroconvulsive therapy be considered in young patients with severe mania when first-line treatment options have failed?Journal of Medical Case Reports (Source: Medscape Today Headlines)

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Between a rock-a-bye and a hard place: mood disorders during the peripartum period - Thomson M, Sharma V.

Tue, 23 Jan 2018 02:24:26 +0100

Mood disorders including major depressive disorder and bipolar disorder are common during and after pregnancy. Timely identification and appropriate management of mood episodes is essential to maximize maternal well-being and minimize adverse outcomes. Fai... (Source: SafetyLit)



The Twisted Psychology of Parents Who Torture Their Children

Fri, 19 Jan 2018 22:57:58 +0100

Don’t try to fathom what was going on in the minds of the California parents who starved and imprisoned their 13 children for years before one of the victims escaped and informed the police last weekend. Really, there is no unraveling it—not fully, at least. Basic empathy and the care of offspring are among the most fundamental lines of code in the human operating system. When that gets corrupted—when the protectors become tormentors, when the nurturers become jailers—it’s nearly impossible to grasp, much less explain. That doesn’t mean that forensic psychologists and others aren’t trying. Even as the Turpin children begin a long period of recovery, and the parents—David Turpin, 56, and Louise Turpin, 49—face sentences of 94 years to li...



C-PTSD and Eating Disorders

Fri, 19 Jan 2018 15:00:36 +0100

As a relatively new and still poorly recognized concept, few people come to therapy identifying as suffering from Complex Post Traumatic Stress Disorder (C-PTSD). As a rule, a diagnosis of C-PTSD comes only after the process of self-discovery in therapy has begun. When people suffering from C-PTSD are referred to a therapist, or decide to seek help for themselves, it is usually because they are seeking help for one of its symptoms, including dissociative episodes, problems forming relationships, and alcohol or substance abuse. One of the more common issues that leads to the discovery of C-PTSD is the presence of an eating disorder, including anorexia, bulimia, and binge eating. In this article, I will explore some of the reasons why C-PTSD often manifests itself in the form of an eating di...



Alterations in peripheral fatty acid composition in bipolar and unipolar depression - Scola G, Versace A, Metherel AH, Monsalve-Castro LA, Phillips ML, Bazinet RP, Andreazza AC.

Thu, 18 Jan 2018 16:42:31 +0100

In this study, we aimed to evaluate levels of fatty acids in patients with unipolar (MDD) and bipolar depression (BDD) in comparison to patients with ... (Source: SafetyLit)



Pavmed registers $90m offering

Thu, 18 Jan 2018 14:40:51 +0100

Pavmed (NSDQ:PAVM) has registered for a nearly $90 million offering, saying it plans to float the rights to buy up to 14.6 million units. The New York City-based company said it would issue a single unit for each share of common stock. Each unit is slated to include one common share and a six-year Series Z warrant worth $2.25 per share, redeemable at $3 apiece. Pavmed plans to use the funds it raises from the offering to support its R&D efforts and the development of its current pipeline, according to the prospectus filed with the SEC. Last week, Pavmed cut the exercise price on the Series W warrants, from $2.50 to $2.00 apiece, its second price cut since late last year. Originally exercisable at $5.00 apiece, the company slashed the price in half last December. In November, Pa...

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Pavmed sets terms for warrants offering

Wed, 17 Jan 2018 20:17:16 +0100

Pavmed (NSDQ:PAVM) said today that it set the terms for a forthcoming rights offering, saying it plans to issue a single unit for each share of common stock. Each unit will include one common share and a six-year Series Z warrant worth $2.25 per share, redeemable at $3 each, the New York City-based company said. Last week, Pavmed cut the exercise price on the Series W warrants, from $2.50 to $2.00 apiece, its second price cut since late last year. Originally exercisable at $5.00 apiece, the company slashed the price in half last December. “Pavmed is providing this opportunity to exercise warrants at a reduced price in order to encourage holders to exercise a meaningful portion of the outstanding warrants, providing the company with additional capital to advance its lead products,...



Voluntary mental health screening program identifying at-risk students at UCLA

Wed, 17 Jan 2018 05:02:47 +0100

Since September, when all of UCLA ’s incoming students were offered free screening for depression, more than 2,600 students have opted to complete a volunteer online screening. Those whose results showed they were at risk of suicide, severe depression or other serious mental health problems were offered access to treatment at UCLA .The screenings are an important part of the  Depression Grand Challenge, an ambitious effort launched by UCLA in 2015 to reduce the burden of depression worldwide by developing better methods of detecting, evaluating and treating depression. The initiative is led by  Dr. Nelson Freimer, director of the Center for Neurobehavioral Genetics at theSemel Institute for Neuroscience and Human Behavior at UCLA, and a UCLA professor of psychiatry.UCLA HealthDr. Nelso...



Marriage and Mania: Disparate Depictions of Bipolar Disorder in Mainstream Romance Novels

Tue, 16 Jan 2018 15:00:59 +0100

When characters with mental illness appear in popular fiction, it is typically because the work itself focuses on the mental illness. However, there is a small contingent of fictional projects that have characters with mental illness that do not make that illness the central plot. These books follow the typical narrative arc and literary conventions of their genre and include conflicts unrelated to mental illness; psychiatric disorder is featured but defines neither the character nor the book.   Authors writing about mental illness, however small or large a part of the plot, can raise public awareness and understanding or can strengthen harmful misconceptions. Two recent romance novels, both of which include a character with bipolar disorder, present strikingly different viewpoints in man...



Integrative understanding of familial impulsivity, early adversity and suicide risk - Lima IMM, Malloy-Diniz LF, de Miranda DM, Da Silva AG, Neves FS, Johnson SL.

Mon, 15 Jan 2018 07:44:25 +0100

INTRODUCTION: Impulsivity is a core characteristic of bipolar disorder and it was observed as elevated in individuals with the disorder and in their relatives. Both impulsivity and history of maltreatment are risk factors for suicide attempts, however, the... (Source: SafetyLit)



Dr. Ronald Fieve, 87, Dies; Pioneered Lithium to Treat Mood Swings

Fri, 12 Jan 2018 23:52:45 +0100

Dr. Fieve and a colleague identified lithium as the first naturally occurring medication to prevent and control a specific psychiatric disorder. (Source: NYT Health)

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Can early symptoms predict bipolar disorder? Evidence shows differing patterns of risk factors

Fri, 12 Jan 2018 05:00:00 +0100

(Wolters Kluwer Health) Two patterns of antecedent or 'prodromal' psychiatric symptoms may help to identify young persons at increased risk of developing bipolar disorder (BD), according to a new analysis in the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)



Pavmed cuts warrant price again

Thu, 11 Jan 2018 21:08:11 +0100

Pavmed (NSDQ:PAVM) said today it would cut the cash exercise price of each of its Series W warrants from $2.50 to $2.00 apiece. This is the second price cut that Pavmed has given for its outstanding warrants. Each of the New York-based company’s outstanding warrants were exercisable at $5.00 apiece for one share of common stock before the company slashed the price in half in December. Pavmed also said today that it plans to implement a rights offering for holders of its common stock. The company will grant one transferable right to buy a new unit of Pavmed securities for each share of outstanding common stock, the company said. Each new unit is slated to include one share of common stock and one Series Z warrant, which will entitle the holder to buy one share of common stock. ̶...



Family study emphasizes distinct origins for bipolar disorder subtypes

Wed, 10 Jan 2018 05:00:00 +0100

(Elsevier) The most common subtypes of bipolar disorder, bipolar I and bipolar II, stem -- at least in part -- from different biological causes, according to a new study published in Biological Psychiatry. Despite genetic overlap between the two subtypes, each subtype tended to cluster within families, suggesting a distinction between bipolar disorders I and II. (Source: EurekAlert! - Social and Behavioral Science)



Remote healing of bipolar disorder, eating disorder not otherwise specified, posttraumatic stress disorder, fibromyalgia, and irritable bowel syndrome through lifestyle change - Brogan K.

Tue, 09 Jan 2018 02:38:50 +0100

This case report illustrates the relationship between gut, hormonal, and brain function in that dietary change, mindfulness interventions, and detoxification led to resolution of disabling psychiatric symptoms. In this case, a single Caucasian female resol... (Source: SafetyLit)



Transcranial DC Stimulation Promising in Bipolar Depression Transcranial DC Stimulation Promising in Bipolar Depression

Mon, 08 Jan 2018 15:57:32 +0100

Transcranial direct current stimulation, added to existing therapy, was safe and effective in a small sham-controlled study of patients with bipolar depression.Medscape Medical News (Source: Medscape Pathology Headlines)

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Mixed features in bipolar I disorder and the effect of lithium on suicide - Terao T, Kanehisa M, Shiotsuki I, Ishii N.

Sun, 07 Jan 2018 02:21:09 +0100

[Abstract unavailable] Language: en... (Source: SafetyLit)



Transcranial Stimulation Promising in Bipolar Depression Transcranial Stimulation Promising in Bipolar Depression

Fri, 05 Jan 2018 22:14:09 +0100

Transcranial direct current stimulation, added to existing therapy, was safe and effective in a small sham-controlled study of patients with bipolar depression.Medscape Medical News (Source: Medscape Medical News Headlines)



Transcranial Direct Current Stimulation Promising for Bipolar

Fri, 05 Jan 2018 18:00:00 +0100

tDCS seems effective and safe for adults with bipolar depression receiving stable pharmacologic regimen (Source: The Doctors Lounge - Psychiatry)



LivaNova launches VNS treatment-resistant depression trial

Fri, 05 Jan 2018 16:49:45 +0100

LivaNova (NSDQ:LIVN) said yesterday it launched a new trial of its VNS therapy system exploring its use treating patients with treatment-resistant depression and that it enrolled the first patient in the trial. The first patient in the trial was enrolled by Karl-Jürgen Bär of Germany’s Universitätsklinikum Jena, the London-based company said. “Treatment-resistant depression, or difficult-to-treat depression, is an area of mental health in need of additional proven treatment options. Up to one-third of patients suffering from depression do not respond to several attempts at treatment. This real-world study will help further define the near- and long-term benefits of VNS Therapy as an adjunctive treatment within this patient population,” Bär said in a prepared statem...



More proof prescriptions and pregnancy don’t mix: Epilepsy drug found to affect fetal development, causing cleft palate

Thu, 04 Jan 2018 22:54:31 +0100

(Natural News) In the last 10 years, topiramate, an anti-epileptic drug, has been increasingly prescribed to prevent seizures. It is also used to treat bipolar disorder and migraine headaches. Topiramate is also an ingredient for a weight-loss drug that was recently approved by the Food and Drug Administration (FDA). Earlier studies have determined that women who took topiramate... (Source: NaturalNews.com)

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Structural covariance network centrality in maltreated youth with posttraumatic stress disorder - Sun D, Peverill MR, Swanson CS, McLaughlin KA, Morey RA.

Thu, 04 Jan 2018 16:41:52 +0100

Childhood maltreatment is associated with posttraumatic stress disorder (PTSD) and elevated rates of adolescent and adult psychopathology including major depression, bipolar disorder, substance use disorders, and other medical comorbidities. Gray matter vo... (Source: SafetyLit)



'I was in a really negative terrible place'

Wed, 03 Jan 2018 23:54:57 +0100

Anxiety, depression, eating disorders, OCD and bipolar disorder are among problems reported by a study. (Source: BBC News | Health | UK Edition)



Socioeconomic disparities and metabolic risk in veterans with serious mental illness - Caroff SN, Leong SH, Ng-Mak D, Campbell EC, Berkowitz RM, Rajagopalan K, Chuang CC, Loebel A.

Wed, 03 Jan 2018 21:20:51 +0100

Socioeconomic disparities were assessed in predicting metabolic risk among veterans with serious mental illness. Veterans with schizophrenia, schizoaffective, or bipolar disorders were identified in VISN 4 facilities from 10/1/2010 to 9/30/2012. Difference... (Source: SafetyLit)



A Vital Part of Successfully Managing Bipolar Disorder

Wed, 03 Jan 2018 15:00:38 +0100

Bipolar disorder can feel like a roller coaster in the dark. You don’t know when the turns or drops are coming. You don’t know when you’ll be flipped upside-down. And once you do, it’s too late. You’re in a manic episode, doing things you’ll regret. You’re in a depressive episode, too exhausted to get out of bed. You feel like you’re being whipped around by an erratic condition, and you have zero control. You’re simply along for the ride. Which is why self-awareness is so vital. Self-awareness is essential to successfully managing bipolar disorder—and not feeling like you’re plunging headfirst into an abyss. You can learn how your bipolar disorder manifests and functions. You can identify your personal triggers and red flags that signal an episode coming on. You c...



Electrical Stimulation Works as Add-On in Bipolar Depression (CME/CE)

Sun, 31 Dec 2017 15:00:00 +0100

(MedPage Today) -- Offered antidepressant effects in small clinical trial (Source: MedPage Today Psychiatry)

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Pavmed offers warrants at half-price to raise cash for carpal tunnel syndrome device

Fri, 29 Dec 2017 14:31:35 +0100

Pavmed (NSDQ:PAVM) said this week that it plans to temporarily cut the exercise price of its outstanding Series W warrants in half. Each of the New York-based company’s outstanding warrants is currently exercisable at $5.00 apiece for one share of common stock. After Pavmed files tender offer materials, each warrant will have an exercise price of $2.50 per share. The company said it expects the offer will be good for 20 business days, but it could decide to extend the deal. “Pavmed is providing this opportunity to exercise warrants at a reduced price in order to encourage holders to exercise a meaningful portion of the outstanding warrants, providing the company with additional capital to advance its lead products, particularly its CarpX minimally invasive carpal tunnel syndro...



Accuracy of Bipolar Diagnoses in Nursing Home Residents Challenged

Fri, 29 Dec 2017 08:12:02 +0100

A new study calls into question the accuracy of bipolar diagnoses in nursing home residents, since about three-quarters of residents with the diagnosis also had a previous dementia diagnosis. (Source: Caring for the Ages)



UAB to be part of new clinical trial studying severe bipolar disorder

Wed, 27 Dec 2017 17:59:27 +0100

A Delaware-based biopharma company and UAB are partnering to become a clinical trial center for a new treatment for severe bipolar disorder. NeuroRx has signed an agreement with UAB to become the site to study a new drug regimen to help treat patients with severe bipolar depression in patients with Acute Suicidal Ideation and Behavior, or ASIB. The company singed a Cooperative Research and Development agreement with the U.S. Departmen t of Veterans Affairs to develop the first drug regimen to treat… (Source: bizjournals.com Health Care News Headlines)



NeuroRx Signs Agreement With U.S. Dept. of Veterans Affairs and Baylor College of Medicine for Clinical Trial of First Drug Regimen Targeting Severe Bipolar Depression in Patients With Acute Suicidal Ideation and Behavior (ASIB)

Wed, 27 Dec 2017 13:31:37 +0100

Third clinical research site for NRX-100 / NRX-101 phase 2B/3 clinical study WILMINGTON, Del., Dec. 27, 2017 -- (Healthcare Sales & Marketing Network) -- NeuroRx, a clinical stage biopharma company developing the first drug regimen to treat severe bipo... Biopharmaceuticals, Neurology NeuroRx, bipolar depression, ASIB (Source: HSMN NewsFeed)

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Variability of activity patterns across mood disorders and time of day - Krane-Gartiser K, Vaaler AE, Fasmer OB, S ørensen K, Morken G, Scott J.

Mon, 25 Dec 2017 08:44:29 +0100

This study compared objectively measured activity in UP, BD depression, mania ... (Source: SafetyLit)



Clinical correlates of loss of insight in bipolar depression - Silva RAD, Mograbi DC, Camelo EVM, Santana CMT, Landeira-Fernandez J, Cheniaux E.

Mon, 25 Dec 2017 08:44:29 +0100

INTRODUCTION: Affective state may influence insight, especially regarding mania. Nevertheless, studies have so far suggested that depression seems not to significantly impair insight. To the best of our knowledge, this study pioneers the evaluation of how ... (Source: SafetyLit)



Is "early intervention" in bipolar disorder what it claims to be? - Malhi GS, Morris G, Hamilton A, Outhred T, Mannie Z.

Mon, 25 Dec 2017 08:44:29 +0100

BACKGROUND: The notion of early intervention is understandably appealing for conditions such as bipolar disorder (BD), a chronic life-long illness that increases risk of suicide and diminishes quality of life. It is purported that intervening early in the ... (Source: SafetyLit)



Putative mechanisms of action and clinical use of lithium in children and adolescents: a critical review - Pisano S, Pozzi M, Catone G, Scrinzi G, Clementi E, Coppola G, Milone A, Bravaccio C, Santosh P, Masi G.

Thu, 21 Dec 2017 09:18:01 +0100

BACKGROUND: Lithium is a first-line treatment for bipolar disorder in adults, but its mechanism of action is still far from clear. Furthermore, evidences of its use in pediatric populations are sparse, not only for bipolar disorders, but also for other pos... (Source: SafetyLit)



Childhood maltreatment is associated with attachment insecurities, dissociation and alexithymia in bipolar disorder - Kefeli MC, Turow RG, Y ıldırım A, Boysan M.

Wed, 20 Dec 2017 14:20:29 +0100

Child maltreatment is a public health issue that is a well-established risk factor for many psychological conditions, including bipolar disorder. The current study is one of the first to investigate associations among child maltreatment, dissociative sympt... (Source: SafetyLit)

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Allergan, Richter's bipolar depression drug succeeds in key trial

Mon, 18 Dec 2017 14:01:37 +0100

(Reuters) - Allergan Plc and Hungary's Gedeon Richter Plc said on Monday their drug to treat severe bipolar depression in adults met the main goal of a late-stage study, bringing the them closer to getting another approval for the drug. (Source: Reuters: Health)



Memory test to help stop bipolar disorder

Sun, 17 Dec 2017 11:26:48 +0100

People with family members who suffer bipolar disorder are up to six times more likely to develop the condition - which affects just one percent of the British population. (Source: the Mail online | Health)



After searching 12 years for bipolar disorder's cause, U-M team concludes it has many

Fri, 15 Dec 2017 05:00:00 +0100

(Michigan Medicine - University of Michigan) Nearly 6 million Americans have bipolar disorder, and most have probably wondered why. After more than a decade of studying over 1,100 of them in-depth, a team of scientists has an answer -- or rather, seven answers. (Source: EurekAlert! - Medicine and Health)



Woman 'prescribed' orgasms by doctor to treat depression

Wed, 13 Dec 2017 12:41:18 +0100

Penny Sullivan, from Australia, was diagnosed with  bipolar. Then her doctor prescribed 'as much sex as she could handle'. Semen contains mild anti-depressant compounds, says expert. (Source: the Mail online | Health)



Prevalence of childhood trauma and correlations between childhood trauma, suicidal ideation, and social support in patients with depression, bipolar disorder, and schizophrenia in southern China - Xie P, Wu K, Zheng Y, Guo Y, Yang Y, He J, Ding Y, Peng H.

Tue, 12 Dec 2017 13:23:29 +0100

BACKGROUND: Childhood trauma has long-term adverse effects on physical and psychological health. Previous studies demonstrated that suicide and mental disorders were related to childhood trauma. In China, there is insufficient research available on childho... (Source: SafetyLit)

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UTHealth researchers link epigenetic aging to bipolar disorder

Tue, 12 Dec 2017 05:00:00 +0100

(University of Texas Health Science Center at Houston) Bipolar disorder may involve accelerated epigenetic aging, which could explain why persons with the disorder are more likely to have -- and die from -- age-related diseases, according to researchers from McGovern Medical School at UTHealth in Houston. (Source: EurekAlert! - Medicine and Health)



Updated brain cell map connects various brain diseases to specific cell types

Mon, 11 Dec 2017 05:00:00 +0100

(University of California - San Diego) Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer's, Parkinson's, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered which of these subtypes are most susceptible to common risk factors for different brain diseases. (Source: EurekAlert! - Medicine and Health)



Drug-Induced Psychosis Ups Schizophrenia, Bipolar Risk Drug-Induced Psychosis Ups Schizophrenia, Bipolar Risk

Fri, 08 Dec 2017 17:58:02 +0100

In almost 6800 patients with psychosis that was induced by any substance, 32% converted to either schizophrenia or bipolar disorder; 47% converted after cannabis-induced psychosis.Medscape Medical News (Source: Medscape Medical News Headlines)






Cannabis use and hypomania in young people: a prospective analysis - Marwaha S, Winsper C, Bebbington P, Smith D.

Thu, 07 Dec 2017 08:20:41 +0100

BACKGROUND: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis u... (Source: SafetyLit)

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Smartphone addiction causes brain chemistry imbalance

Wed, 06 Dec 2017 20:32:10 +0100

Smartphones are nearly ubiquitous these days, but it may be wise -- for your...Read more on AuntMinnie.comRelated Reading: EAN 2017: Smartphone use can damage median nerve Can AI predict treatment response in bipolar patients? MRI sees brain differences in schizophrenics fMRI shows different brain activity in curious preteens MRS helps diagnose traumatic brain disorder in athletes (Source: AuntMinnie.com Headlines)



Study shows lithium chloride blunts brain damage linked to fetal alcohol syndrom

Tue, 05 Dec 2017 05:00:00 +0100

(NYU Langone Health / NYU School of Medicine) A single dose of lithium chloride, a drug used to treat bipolar disease and aggression, blocks the sleep disturbances, memory loss, and learning problems tied to fetal alcohol syndrome, new experiments in mice show. (Source: EurekAlert! - Medicine and Health)



Medical News Today: Teen marijuana use may lead to bipolar symptoms later on

Mon, 04 Dec 2017 16:00:00 +0100

A prospective study examines the link between cannabis use at the age of 17 –18 and hypomania — a common symptom of bipolar disorder — in early adulthood. (Source: Health News from Medical News Today)



Traumatic stress and genetic risk of bipolar disorder found to increase suicide attempts

Mon, 04 Dec 2017 05:00:00 +0100

(Elsevier) Genetic susceptibility to bipolar disorder can increase the risk for suicide attempt, but only among those who also have experienced traumatic stress, reports a study published in the December 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). (Source: EurekAlert! - Social and Behavioral Science)



Traumatic stress interacts with bipolar disorder genetic risk to increase risk for suicide attempts - Wilcox HC, Fullerton JM, Glowinski AL, Benke K, Kamali M, Hulvershorn LA, Stapp EK, Edenberg HJ, Roberts GMP, Ghaziuddin N, Fisher C, Brucksch C, Frankland A, Toma C, Shaw AD, Kastelic E, Miller L, McInnis MG, Mitchell PB, Nurnberger JI.

Fri, 01 Dec 2017 17:09:01 +0100

OBJECTIVE: Bipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk score in... (Source: SafetyLit)

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'We aim to hit the charts'

Fri, 01 Dec 2017 14:30:16 +0100

Pete Hirst has bipolar disorder and was sectioned after a spell of psychosis. (Source: BBC News | Health | UK Edition)



Cannabis increases the risk of bipolar disorder

Fri, 01 Dec 2017 13:55:20 +0100

Researchers from Warwick Medical School found people who used cannabis at least two-to-three times a week at 17 years old are more likely to experience hypomania in their early 20s. (Source: the Mail online | Health)



Book Review: Another Kind of Madness

Thu, 30 Nov 2017 23:10:21 +0100

“There are times that I wish I had cancer.” It is difficult to imagine that anyone would wish for cancer. But through the eyes of someone diagnosed with a mental illness, this statement may make more sense. The cultural perception that cancer is a “real” illness and mental health challenges are weaknesses or character flaws is just one example of why efforts to reduce stigma are needed. In Another Kind of Madness, Stephen Hinshaw shares his story of growing up with the unexplained absences of his father. It wasn’t until his father shared information about his bipolar diagnosis while Hinshaw was in college that he was able to better understand the absences. Hinshaw compares the stigma around mental illness to other marginalized groups throughout history, such as the LGBTQ communit...



Book Review: Tough-To-Treat Anxiety

Thu, 30 Nov 2017 21:10:05 +0100

Anxiety is one of the most common problems people face today, and yet, it is often complicated with other co-existing conditions, such as obsessive compulsive disorder, autism, and depression. Comorbidity can make treatment challenging, even for clinicians who specialize in anxiety. In her new book, Tough-To-Treat Anxiety: Hidden Problems & Effective Solutions For Your Clients, licensed clinical psychologist Margaret Wehrenberg breaks down anxiety into its most common presentations, offering a host of treatment methods that work in the moment, and resist remission for years to come. “Unremitting anxiety may be one the most frustrating situations any individual can face. Family and friends tell worriers, ‘Just don’t worry!’ as if they are somehow choosing to feel anxious...



Rates and predictors of conversion to schizophrenia or bipolar disorder following substance-induced psychosis - Starzer MSK, Nordentoft M, Hjorth øj C.

Thu, 30 Nov 2017 11:42:05 +0100

OBJECTIVE: The authors investigated the rates of conversion to schizophrenia and bipolar disorder after a substance-induced psychosis, as well as risk factors for conversion. METHOD: All patient information was extracted from the Danish Civil Regis... (Source: SafetyLit)

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Pavmed files FDA 510(k) for CarpX carpal tunnel device

Tue, 28 Nov 2017 18:02:06 +0100

Pavmed (NSDQ:PAVM) said today it filed a 510(k) application with the FDA for its CarpX minimally invasive device designed to treat carpal tunnel syndrome. The CarpX is a percutaneous device designed to allow the operating physician to relieve compression of the median nerve without a surgical incision. The system combines a balloon catheter with bipolar radio-frequency cutting electrodes and is positioned through guidance with ultrasound, the company said. “I have had the opportunity to use Pavmed’s highly innovative CarpX device in pre-submission testing and am very impressed with its performance. As a busy hand surgeon, I strongly believe that CarpX will be a game-changer in the treatment of carpal tunnel syndrome, providing patients with a much less invasive option and signific...



Simple ECG May Help Distinguish MDD From Bipolar Depression

Tue, 28 Nov 2017 18:00:00 +0100

Higher low - frequency heart rate variability, lower levels of IL - 10 and MCP - 1 for major depression (Source: The Doctors Lounge - Psychiatry)



Light Therapy Might Help People With Bipolar Depression

Mon, 27 Nov 2017 10:02:00 +0100

(Source: NPR Health and Science)



C-PTSD and Interpersonal Relationships

Sun, 26 Nov 2017 15:00:41 +0100

As I have discussed in other articles, Complex Post Traumatic Stress Disorder (C-PTSD) is a unique condition that is the result of suffering a series of traumatic incidents over a long period of time at the hands of someone the victim has a dependent relationship with, usually a parent or other primary caregiver. C-PTSD shares many features of the better known PTSD (Post Traumatic Stress Disorder) which is the result of a small number of impersonal traumas, such as car accidents. However, it also has many unique features, which give it a dual nature, in some ways more similar to some personality disorders, or other disorders such as bipolar disorder, with which it is often confused. In my work with clients who suffer from C-PTSD, I am frequently struck with how difficult it is for them to...



Differentiating multiple vs single lifetime suicide attempters with bipolar disorders: a retrospective study - Arici C, Cremaschi L, Dobrea C, Vismara M, Grancini B, Benatti B, Buoli M, Miller S, Ketter TA, Altamura AC, Dell'osso B.

Sat, 25 Nov 2017 14:38:59 +0100

BACKGROUND: The risk of suicide in Bipolar Disorder (BD) has been estimated up to 20-30 times higher compared with the general population. Previous suicide attempts (SAs) represent a well-established risk factor for further attempts and for death by suicid... (Source: SafetyLit)

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Predictors of suicide ideation among older adults with bipolar disorder - O'Rourke N, Heisel MJ, Canham SL, Sixsmith A.

Sat, 25 Nov 2017 05:18:19 +0100

OBJECTIVES: Bipolar disorder (BD) carries the greatest risk of death by suicide of all psychiatric conditions as 25%-50% of those with BD will make one or more suicide attempt, and about 15% will intentionally end their lives. Among young adults with BD, s... (Source: SafetyLit)



How to avoid being stressed this holiday season

Thu, 23 Nov 2017 17:15:45 +0100

Holiday stress gets the best of many Americans, but experts explain how to have more merry and less manic this year, whether you're a perfectionist, a family feud-er or just feeling a little lonely. (Source: the Mail online | Health)



Don't fear the holiday cheer: Avoid stress this season

Wed, 22 Nov 2017 22:41:53 +0100

Holiday stress gets the best of many Americans, but experts explain how to have more merry and less manic this year, whether you're a perfectionist, a family feud-er or just feeling a little lonely. (Source: the Mail online | Health)



Simple EKG can determine whether patient has depression or bipolar disorder

Mon, 20 Nov 2017 05:00:00 +0100

(Loyola University Health System) A groundbreaking Loyola Medicine study suggests that a simple 15-minute electrocardiogram could help a physician determine whether a patient has major depression or bipolar disorder. (Source: EurekAlert! - Medicine and Health)



In-Depth: How digital sensors could change the face of pharma

Fri, 17 Nov 2017 21:54:28 +0100

Earlier this week, Proteus Digital Health and Otsuka Pharmaceuticals announced that Abilify MyCite, a new, sensor-enabled version of Otsuka ’s drug for schizophrenia, had received FDA approval for mental health conditions including schizophrenia and bipolar disorder. (Source: mobihealthnews)

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Otsuka, Proteus finally win FDA approval for sensor-equipped Abilify

Tue, 14 Nov 2017 20:27:08 +0100

The first drug in the US with a digital ingestion tracking system has been approved by the FDA. The pill, Abilify MyCite, is prescribed for treatment of schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I disorder and as an add-on treatment for depression in adults. (Source: mobihealthnews)



FDA approves first trackable pill that syncs with a phone

Tue, 14 Nov 2017 19:38:01 +0100

The FDA approved a pill that tracks when patients take their prescribed psychiatric drug. The medication, Abilify MyCite, is a variation on a drug used to treat schizophrenia and bipolar disorder. (Source: the Mail online | Health)



'Digital Pill' Lets Doctors Know It's Been Taken

Tue, 14 Nov 2017 17:08:47 +0100

The U.S. Food and Drug Administration has given the nod to Abilify MyCite, for use in patients with schizophrenia, an add-on treatment for depression, and to help control episodes of either manic or "mixed" episodes for people with bipolar disorder. (Source: WebMD Health)



FDA OKs First 'Digital Pill' That Lets Doctors Know It's Been Taken

Tue, 14 Nov 2017 16:15:13 +0100

The U.S. Food and Drug Administration has given the nod to Abilify MyCite, for use in patients with schizophrenia, an add-on treatment for depression, and to help control episodes of either manic or "mixed" episodes for people with bipolar disorder. (Source: WebMD Health)

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FDA approves first pill with sensor to track ingestion

Tue, 14 Nov 2017 13:14:20 +0100

The FDA today approved Abilify MyCite, the first drug in the U.S. to have an ingestible sensor embedded within the pill that can track if the medication was taken. The drug-device combination product is indicated for the treatment of schizophrenia, acute treatment of manic and mixed episodes linked with bipolar I disorder and as an add-on treatment for depression in adults. Get the full story at our sister site, Drug Delivery Business News. The post FDA approves first pill with sensor to track ingestion appeared first on MassDevice. (Source: Mass Device)



FDA approves pill with sensor that digitally tracks if patients have ingested their medication

Tue, 14 Nov 2017 00:00:00 +0100

The U.S. Food and Drug Administration today approved the first drug in the U.S. with a digital ingestion tracking system. Abilify MyCite (aripiprazole tablets with sensor) has an ingestible sensor embedded in the pill that records that the medication was taken. The product is approved for the treatment of schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I disorder and for use as an add-on treatment for depression in adults. (Source: Food and Drug Administration)



FDA Approves Pill with Sensor that Digitally Tracks if Patients Have Ingested their Medication

Tue, 14 Nov 2017 00:00:00 +0100

The U.S. Food and Drug Administration has approved the first drug in the U.S. with a digital ingestion tracking system. Abilify MyCite (aripiprazole tablets with sensor) has an ingestible sensor embedded in the pill that records that the medication was taken. The product is approved for the treatment of schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I disorder and for use as an add-on treatment for depression in adults. (Source: eHealth News EU)



FDA approves pill with sensor that digitally tracks if patients have ingested their medication

Tue, 14 Nov 2017 00:00:00 +0100

The U.S. Food and Drug Administration has approved the first drug in the U.S. with a digital ingestion tracking system. Abilify MyCite (aripiprazole tablets with sensor) has an ingestible sensor embedded in the pill that records that the medication was taken. The product is approved for the treatment of schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I disorder and for use as an add-on treatment for depression in adults. (Source: World Pharma News)



The differential association between history of childhood sexual abuse and body mass index in early and late stages of bipolar disorder - Leclerc E, Mansur RB, Grassi-Oliveira R, Cordeiro Q, Kapczinski F, McIntyre RS, Brietzke E.

Mon, 13 Nov 2017 13:18:22 +0100

The objective of this study was to investigate the possible association between history of childhood tr... (Source: SafetyLit)

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Man runs 1,250 miles from Colosseum to the London Eye

Thu, 09 Nov 2017 11:54:25 +0100

Dan Keeley, who has bipolar disorder, completed the gruelling 1,250 mile run in aid of a charity. (Source: BBC News | Health | UK Edition)



Genes May Explain Why Some Don't Respond to Bipolar Drug

Thu, 09 Nov 2017 07:00:00 +0100

Title: Genes May Explain Why Some Don't Respond to Bipolar DrugCategory: Health NewsCreated: 11/8/2017 12:00:00 AMLast Editorial Review: 11/9/2017 12:00:00 AM (Source: MedicineNet Depression General)



Genes May Explain Why Some Don ’ t Respond to Bipolar Drug

Wed, 08 Nov 2017 18:00:00 +0100

(Source: The Doctors Lounge - Psychiatry)



Genes May Explain Why Some Don't Respond to Bipolar Drug

Wed, 08 Nov 2017 17:00:00 +0100

Source: HealthDay Related MedlinePlus Pages: Bipolar Disorder, Genes and Gene Therapy, Medicines (Source: MedlinePlus Health News)



Gene breakthrough on lithium treatment for bipolar disorder

Wed, 08 Nov 2017 05:00:00 +0100

(University of Adelaide) Genes linked to schizophrenia in psychiatric patients suffering from bipolar disorder are the reason why such patients don't respond to the 'gold standard' treatment for bipolar -- the drug lithium -- according to international research led by the University of Adelaide. (Source: EurekAlert! - Social and Behavioral Science)



Growing Up with a Psychotic Mother

Mon, 06 Nov 2017 15:00:11 +0100

I was ten when my mother had her first psychotic break. It was May. I was looking forward to lazy summer days at the pool, an art camp, a stack of Babysitters Club books, and daydreaming about my first crush, a boy with a splay of freckles and a mop of dark hair. Instead, I was forced to grow up too soon. This meant wearing deodorant and shaving my arm pits. It also meant seeing my mother in a state of complete psychosis, one in which she thought maybe she had killed the postman or the neighbor girl. “I didn’t. Mean. Tokillthepostman.” Her words were all wrong, strung together in a series of hiccups and stretched entirely too thin, like a ribbon was attached at the end. She pranced around the house naked, claiming no one should be ashamed of their body. My mother had recently ha...