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MedWorm: Bipolar



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Bipolar category.



Last Build Date: Tue, 22 Mar 2016 08:27:00 +0100

 



Management of Large Prostate Gland in Men with Impaired Renal Function: Comparison of Safety, Efficacy and Outcomes of Monopolar, Bipolar Transurethral Resection and Open Prostatectomy

Mon, 21 Mar 2016 18:07:27 +0100

Conclusion: This category of patients can be managed safely and efficiently by all the 3 procedures, although BP-TURP has an advantage in terms of shorter catheterization, hospitalization and fewer complications like transurethral resection syndrome.Urol Int (Source: Urologia Internationalis)

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Bipolar disorder: Emergency, illness, recovery, stability

Mon, 21 Mar 2016 12:56:32 +0100

In March 2010, Pam Lipp received the call she'd been dreading for months. She figured it would come from one of three places: the police, the hospital or the morgue. Instead, it was her husband, Doug, saying that he'd just received word that their 18-year-old daughter, Amanda, a freshman at Chico State University in California, was being held at a psychiatric crisis center after trying to throw herself in front of a moving car. Amanda had lost her grip on reality and fallen into a state of psychosis. She'd started selling off her belongings and believed that cameras were following her everywhere. (Source: CNN.com - Health)



Vortioxetine in bipolar depression induces a mixed/manic switch.

Mon, 21 Mar 2016 05:16:02 +0100

Authors: Maud C PMID: 26994277 [PubMed - in process] (Source: Australasian Psychiatry)



Evaluation of the validity and utility of a transdiagnostic psychosis dimension encompassing schizophrenia and bipolar disorder.

Mon, 21 Mar 2016 04:35:02 +0100

CONCLUSIONS: Our findings provide support for including dimensional approaches into classification systems and a directly measurable clinical phenotype for cross-disorder investigations into shared genetic and environmental factors of psychosis. PMID: 26989099 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)



New insights into the endophenotypic status of cognition in bipolar disorder: genetic modelling study of twins and siblings.

Mon, 21 Mar 2016 04:35:02 +0100

CONCLUSIONS: Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder. PMID: 26989096 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)



Differentiation of murine models of “negative ERG” by single and repetitive light stimuli

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Consideration of both single-flash and flickering ERG responses can discriminate the functional pathology of the negative ERG in these animal models of human disease. (Source: Documenta Ophthalmologica)

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Non-invasive expandable prosthesis in musculoskeletal oncology paediatric patients for the distal and proximal femur. First results

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions The non-invasive expandable prosthesis reduces the final limb-length discrepancy in growing patients with an acceptable function and appears to have an advantage as compared to invasive expandable prostheses which require multiple surgical procedures, but the complications rate is still high. (Source: International Orthopaedics)



Lamotrigine improves bipolar depression, but folic acid counteracts effects

Mon, 21 Mar 2016 00:00:00 +0100

A 12‐week study of patients with bipolar disorder has found that a combination treatment of quetiapine and lamotrigine led to greater improvement in depressive symptoms than quetiapine alone, but use of folic acid during the study period acted to nullify lamotrigine's effects. These findings, coupled with data from an earlier study, appear to confirm lamotrigine's effectiveness in the treatment of bipolar depression. Study results were published online Dec. 10, 2015, in Lancet Psychiatry. (Source: The Brown University Psychopharmacology Update)



Learn the Possible Side Effects of Anti-Psychot...

Mon, 21 Mar 2016 00:00:00 +0100

The anti-psychotic drug Navane, used for bipolar disorder and other conditions, has many possible side effects, including some that are quite serious. (Source: About.com Bipolar Disorder)



What You Should Know if Your Doctor Prescribes...

Mon, 21 Mar 2016 00:00:00 +0100

Learn more about the benzodiazepine Ativan, also known as lorazepam, including what health conditions its used for, precautions, and side effects. (Source: About.com Bipolar Disorder)



Medications Can Cause You to Grind Your Teeth

Mon, 21 Mar 2016 00:00:00 +0100

Do you grind your teeth or clench your jaws? You may have bruxism, which can be caused by stress, anxiety or even be a side effect of medication. (Source: About.com Bipolar Disorder)

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5 Dietary Guidelines to Help Keep Lithium...

Mon, 21 Mar 2016 00:00:00 +0100

Hyponatremia is a low concentration of sodium in the blood. It can occur as a side effect of some medications that are used to treat bipolar disorder. (Source: About.com Bipolar Disorder)



Quetiapine use in adults in the community: a population-based study in Alberta, Canada

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions The current study of quetiapine use in the province of Alberta provides confirmatory data of the increasing use of quetiapine for the treatment of depression and anxiety disorders. Safe and rational prescribing practices must be encouraged in light of the modest advantages of quetiapine over no treatment as an adjunctive treatment of major depression, and the known harms of this medication. (Source: BMJ Open)



Age associations with neural processing of reward anticipation in adolescents with bipolar disorders

Sun, 20 Mar 2016 00:00:00 +0100

Publication date: Available online 18 March 2016 Source:NeuroImage: Clinical Author(s): Snežana Urošević, Monica Luciana, Jonathan B. Jensen, Eric A. Youngstrom, Kathleen M. Thomas Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using...



Divalproex sodium leading to sustained significant improvement in tardive dyskinesia in a patient with bipolar disorder.

Sat, 19 Mar 2016 16:49:03 +0100

Authors: Pattanayak RD, Charan D PMID: 26985118 [PubMed] (Source: Indian Journal of Psychiatry)



Animal models of bipolar mania: The past, present and future

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: 3 May 2016 Source:Neuroscience, Volume 321 Author(s): R.W. Logan, C.A. McClung Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the World Health Organization and affects nearly six million (∼2.5% of the population) adults in the United State alone each year. BD is primarily characterized by mood cycling of depressive (e.g., helplessness, reduced energy and activity, and anhedonia) and manic (e.g., increased energy and hyperactivity, reduced need for sleep, impulsivity, reduced anxiety and depression), episodes. The following review describes several animal models of bipolar mania with a focus on more recent findings using genetically modified mice, including several with the potential of investigating the mechanisms underlying...

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Animal models of recurrent or bipolar depression

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: 3 May 2016 Source:Neuroscience, Volume 321 Author(s): T. Kato, T. Kasahara, M. Kubota-Sakashita, T.M. Kato, K. Nakajima Animal models of mental disorders should ideally have construct, face, and predictive validity, but current animal models do not always satisfy these validity criteria. Additionally, animal models of depression rely mainly on stress-induced behavioral changes. These stress-induced models have limited validity, because stress is not a risk factor specific to depression, and the models do not recapitulate the recurrent and spontaneous nature of depressive episodes. Although animal models exhibiting recurrent depressive episodes or bipolar depression have not yet been established, several researchers are trying to generate such animals by modeling cl...



Use of a novel saline/bipolar radiofrequency energy instrument as an adjunct for arresting ongoing solid organ surface and laceration bleeding in critically injured patients

Sat, 19 Mar 2016 00:00:00 +0100

Solid organ (liver, spleen and kidney) hemorrhage is often life threatening and can be difficult to stop in critically ill patients. Traditional techniques for arresting this ongoing bleeding include coagulation by high voltage cautery (Bovie), topical hemostatic application, and the delivery of ignited argon gas. The goal of this study was to evaluate the efficacy of a new energy device for arresting persistent solid organ hemorrhage. (Source: Injury)



Surgical technique for en bloc transurethral resection of bladder tumor with a Hybrid Knife®

Sat, 19 Mar 2016 00:00:00 +0100

Conclusion The technique of en bloc bladder tumor resection with Hybrid Knife® is an effective alternative to bipolar loop transurethral resection. Resection with a Hybrid Knife® is a procedure with little bleeding and good surgical vision and minimizes the risk of bladder perforation and tumor implants. The procedure facilitates determining the positivity of the neoplastic process, vascular infiltration and bladder muscle invasion in the histopathology study. (Source: Actas Urologicas Espanolas)



Effectiveness of illness management and recovery (IMR) in the Netherlands: a randomised clinical trial

Sat, 19 Mar 2016 00:00:00 +0100

Illness Management and Recovery (IMR) is intended to provide a structured psychosocial programme that helps to manage the disabling effects of severe mental illnesses such as schizophrenia and bipolar disorder... (Source: BMC Psychiatry)



Associations Between Psychotic Experiences, Mental Disorders Found to Be Bidirectional

Fri, 18 Mar 2016 20:47:00 +0100

While previous studies suggest that psychotic experiences are associated with an elevated risk of subsequent mental disorders, the findings of a study published online today in AJP in Advance also suggest that most mental disorders are associated with an elevated risk of subsequent psychotic experiences.John McGrath, M.D., Ph.D. (pictured above), a professor of psychiatry at the University of Queensland in Brisbane, Australia, and colleagues drew on data gathered by trained lay interviewers on 31,261 people in 18 countries as part of the World Health Organization’s World Mental Health Surveys. They were looking not just for prevalence of psychotic experiences and mental illnesses but for any temporal associations between the two.Of the 21 common mental disorders studied, psychotic experi...

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[A girl with foetal valproate syndrome and autism spectrum disorder].

Fri, 18 Mar 2016 06:03:02 +0100

Authors: Solignac I Abstract We study the case of a 12-year-old girl who, following intra-uterine exposure to valproate, was diagnosed with foetal valproate syndrome, characterised at birth by dysmorphic features. The use of valproate during pregnancy (because of epilepsy or bipolar disorder) can cause not only structural defects in the growing foetus, but also problems in cognitive development and in adaptive and emotional/behavioural functioning in later life. We evaluate these domains of development in our discussion and suggest several other drugs, less harmful than valproate, which can be used to treat epilepsy or bipolar disorder during pregnancy. PMID: 26979855 [PubMed - in process] (Source: Tijdschrift voor Psychiatrie)



[The general practitioner in charge of treatment of patients with bipolar disorder: an exploratory study].

Fri, 18 Mar 2016 06:03:02 +0100

CONCLUSION: Given these low numbers, it is unlikely that the gps can have adequate experience of giving their bd patients the latest type of treatment. In view of the increasing role played by gps in the treatment of bd, it is important that there is strong collaboration with specialised mental health care, and that a low threshold prevails for consultation and referral. PMID: 26979850 [PubMed - in process] (Source: Tijdschrift voor Psychiatrie)



Coping with genetic burden.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Tibben A Abstract An increasing number of neurodegenerative diseases have been defined at the molecular level in recent years, making it possible to determine precisely the genotype before the onset of symptoms. Pre-symptomatic testing programs are available for Huntington disease (HD), hereditary cerebral haemorrhage with amyloid-Dutch type, inherited cerebral ataxia, myotonic dystrophy, and Alzheimer disease. Although treatment options such as gene therapy have no widespread application until now, and much has to be developed, the use of predictive DNA-diagnostics has become a clinical application for a number of hereditary diseases. For psychiatric disorders such as schizophrenia or bipolar disorders, there are indications for localisation of the genetic factors, but cl...



Molecular genetic findings in mood disorders.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Souery D, Mendlewicz J Abstract Traditional methods used to asses genetic effects, such as twins, adoption and family studies, have demonstrated the role genetic vulnerability factors in the etiology of major psychiatric diseases such as affective disorders and schizophrenia. It remains however impossible, using these methods, to specify the genetic variables involved and the exact mode of transmission of these diseases. New genetic approaches in psychiatry include the use of DNA markers in sophisticated strategies to examine families and populations. Genetic linkage (in families) and allelic association (in unrelated subjects) are the most frequent techniques applied searching for genes in psychiatric diseases. Advances in these methods have permitted their application to...



Acute and continuation pharmacological treatment of children and adolescents with bipolar disorders; a summary of two previous studies.

Fri, 18 Mar 2016 04:28:02 +0100

We report the results of an acute-phase and continuation-phase study of the pharmacological treatment of children and adolescents with bipolar disorders. The acute phase study, with a duration of 6-8 weeks, aimed at developing effect sizes (ES) for lithium, divalproex sodium, and carbamazepine, in the acute phase treatment of Bipolar I or II children and adolescents during a mixed or manic episode. During the acute-phase of treatment, 42 outpatients with a mean age of 11.4 yr. (20 with Bipolar I Disorder and 22 with Bipolar II Disorder) were randomly assigned to 6-8 weeks of open treatment with either lithium, divalproex sodium, or carbamazepine. The primary efficacy measures were the weekly CGI Improvement scores and the Young Mania Rating Scale. Using a ≥ 50% change from baseline to ex...

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Prevalence of psychopathology in children of bipolar parents.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Wals M, Hillegers MH, Reichart CG, Ormel J, Nolen WA, Verhulst FC Abstract The purpose of this study was to determine psychopathology in a large sample of adolescent children (N = 140) of parents (N = 86) with bipolar disorders, using multiple sources of information (child, parent, teacher). The main aims of the study were: 1) to compare parent, teacher and self reported problem behavior ratings of children of bipolar parents with those of children from the general population, and 2) to determine the prevalence of DSM-IV diagnoses in offspring of bipolar parents, and 3) to examine the possible association between gender of the bipolar parent and psychopathology among the offspring. PMID: 26975275 [PubMed] (Source: Acta Neuropsychiatrica)



Neural mechanisms of childhood-onset bipolar illness.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Post RM, Leverich GS, Speer AM, Xing G, Weiss SR Abstract Substantial evidence exists for a cohort effect (earlier onset and increased prevalence) for both unipolar and bipolar affective disorder in every generation born since World War II. This effect could be related to inherited mechanisms (e.g., bi-Hneal pedigrees or genetic anticipation) or to environmental/experiential effects on gene expression (e.g., stressor effects on the induction of transcription and growth factors, enzymes, hormones and their receptors, and signal transduction molecules) as documented in preclinical models of neonatal maternal separation. This laboratory evidence is summarized and new clinical data on the impact of severe stressors on the unfolding course of bipolar illness are noted. The repo...



The rationale, design, and progress of two novel maintenance treatment studies in pediatric bipolarity.

Fri, 18 Mar 2016 04:28:02 +0100

DISCUSSION: Since the blind has not been broken on either of these clinical trials, conclusions about the maintenance effectiveness of either VPA or Li+ in youths with bipolar disorder type 1 or 2 cannot be made yet. Similarly, it is unclear whether VPA is superior to placebo in genetically high-risk youths with cyclotaxia. The final results of these trials should provide valuable information about the treatment of juvenile bipolar disorders. PMID: 26975273 [PubMed] (Source: Acta Neuropsychiatrica)



Bipolar disorder in children and adolecents: a clinical reality?

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Reichart CG, Nolen WA, Wals M, Hillegers MH Abstract The appearance, the differential diagnosis and the prevalence of bipolar disorder in children and adolescents is discussed. Among adolescents bipolar disorder appears to have a similar prevalence in the US and The Netherlands. However, among children it is frequently diagnosed in the US and hardly in The Netherlands. It is concluded that bipolar disorder tends to start earlier in the US than in the Netherlands. It is hypothesized that this may be related to a higher use of stimulants and antidepressants by US children diagnosed as ADHD or depression, respectively. PMID: 26975272 [PubMed] (Source: Acta Neuropsychiatrica)



Pediatric mania: a developmental subtype of bipolar disorder?

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Biederman J, Mick E, Faraone SV, Spencer T, Wilens T, Wozniak J Abstract Despite ongoing controversy, the view that pediatric mania is rare or non-existent has been increasingly challenged not only by case reports but also by systematic research. This research strongly suggests that pediatric mania may not be rare but that it may be difficult to diagnose. Since children with mania are likely to become adults with bipolar disorder, the recognition and characterization of childhood-onset mania may help identify a meaningful developmental subtype of bipolar disorder worthy of further investigation. The major difficulties that complicate the diagnosis of pediatric mania include: - its pattern of comorbidity may be unique by adult standards, especially its overlap with ADHD, ag...

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Predicting medication non-adherence in severe affective disorders.

Fri, 18 Mar 2016 04:28:02 +0100

Conclusion Although the study has a number of methodological limitations, the results suggest that clinical assessment of components of HBMs may improve the detection of patients at risk of non-adherence with mood stabilising medication. PMID: 26975270 [PubMed] (Source: Acta Neuropsychiatrica)



The efficacy of valproate, lamotrigine and gabapentin in bipolar disorder; review of double-blind controlled studies.

Fri, 18 Mar 2016 04:28:02 +0100

CONCLUSION: For the prophylaxis of bipolar disorder, lithium is still the treatment of choice. Carbamazepine and valproate are good alternatives, especially for patients not responding to lithium or not tolerating it. Lamotrigine may be a good alternative in bipolar depression. PMID: 26975269 [PubMed] (Source: Acta Neuropsychiatrica)



Lithium and carbamazepine in bipolar disorder.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Moleman P, Hartong EG, Hoogduin CA, Broekman TG, Nolen WA, LitCar Group Abstract Lithium is considered first choice in the prevention of prospective episodes in patients with bipolar disorder. However, efficacy is not satisfactory in all patients and side effects sometimes prevent the use of lithium. It is argued that efficacy in clinical practice may be less impressive than anticipated from clinical trials, and alternative treatments are beinu advocated increasingly for that reason, such as the anticonvulsants, carbamazepine and valproate. PMID: 26975268 [PubMed] (Source: Acta Neuropsychiatrica)



Typical and atypical antipsychotics in bipolar disorder.

Fri, 18 Mar 2016 04:28:02 +0100

CONCLUSIONS: Antipsychotics are beneficial for some clinical presentations of mania. To minimize side effets, atypical agents should be preferred before typical agents, unless parenteral administration is needed. Despite the lack of RCTs, antipsychotics also seem to be useful as adjunctive agents in the treatment of psychotic bipolar depression. For the long term treatment of bipolar disorder, typical antipsychotics should be used only under certain circumstances. The place of atypical antipsychotics in the long term treatment of bipolar disorder remains to be studied. PMID: 26975267 [PubMed] (Source: Acta Neuropsychiatrica)



Stabilization in the treatment of mania, depression and mixed states.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Kupfer DJ, Frank E, Grochocinski VJ, Luther JF, Houck PR, Swartz HA, Mailinger AG Abstract While one major need for improved therapeutic approaches in bipolar disease is the development of long-term treatment strategies, a systematic approach during the acute phase of bipolar disorder is also required. In our own studies we have arbitrarily divided the initial treatment of subjects by the predominant polarity for which they are treated acutely: manic, depressed, or mixed/cycling.1 In this larger investigation of over 150 patients with bipolar disorder, we now demonstrated again that the time to initial stabilization is generally the shortest with a manic episode and the longest with a mixed/cycling episode with the depressed episode in the middle (although almost as long a...

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Accuracy of register- and record-based bipolar I disorder diagnoses in Finland; a study of twins.

Fri, 18 Mar 2016 04:28:02 +0100

We report here the diagnostic procedures and accuracy of bipolar I diagnoses in a nation-wide hospital discharge registry. We evaluated also the accuracy of the medical record-based best-estimate diagnoses, comparing these with the SCID interview diagnoses. From the National Hospital Discharge Register we identified all like-sex twins, born 1940-1957, (N=42), and all like- or opposite-sex twins, born 1961-1969, (N=15), who had at least once a diagnosis of bipolar I disorder. The best-estimate diagnoses based on medical records, and were made by two doctors blind to each other, and according to DSM-IV-criteria. Diag-noses were then confirmed by SCID interviews, with the mi-nimum follow-up time after the first admission being 6 years. The accuracy of bipolar diagnoses in the register was 92%...



Bipolar disorder: is psychiatry's Cinderella starting to get out a little more?

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Goodwin GM Abstract Bipolar Disorder is a neglected disease. In the last twenty years fewer than 2,000 articles have been published with mania or bipolar disorder in the title, compared to 11,000 for schizophrenia and 19,000 for depression (data from EMBASE). This relative neglect of bipolar disorder is true both for neurobiological investigations and for investigations of treatment. Interest is reviving, I believe, in no small part because of the consistent support by the Stanley Foundation. Genuine advances in understanding neurobiology and treatment may be now be possible. The presentations made at this meeting are testimony to that. PMID: 26975264 [PubMed] (Source: Acta Neuropsychiatrica)



The epidemiology of bipolar affective disorder; a review of the literature and introduction to work in progress.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Lloyd T, Jones PB Abstract The past 20 years have seen much research into affective disorders, reflecting advances in both pharmacological and psychological treatments. However, there has been little basic epidemiological research into bipolar illness. This is particularly apparent regarding its basic occurrence and possible epigenetic causes. This presentation will attempt to bring together and integrate the available evidence regarding the basic epidemiology of bipolar disorder, define areas where further research is needed, and outline a large epidemiological study including bipolar affective disorder that has been supported by the Stanley Foundation. PMID: 26975262 [PubMed] (Source: Acta Neuropsychiatrica)



Neuropathological studies of bipolar disorder.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Harrison PJ Abstract The few available neuropathological studies of bipolar disorder are reviewed and placed in the context of structural imaging findings. Candidate pathological processes include cy-toarchitectural abnormalities, particularly in the anterior cingulate cortex and affecting glia, and disruption of white matter connections. The possible neuropathological relationship of bipolar disorder with major depression and with schizophrenia is discussed. PMID: 26975261 [PubMed] (Source: Acta Neuropsychiatrica)



Brain 5-HT function in bipolar affective disorder.

Fri, 18 Mar 2016 04:28:02 +0100

CONCLUSIONS: ATD attenuates auditory evoked potentials in bipolar disorder but does not reverse lithium's effects on mood and suicidally in bipolar disorder. PMID: 26975260 [PubMed] (Source: Acta Neuropsychiatrica)

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Immunological aspects of bipolar disorder.

Fri, 18 Mar 2016 04:28:02 +0100

CONCLUSION: Changes in immune function, in connection with neuroendocrine changes, may provide new hypotheses for the pathophysiology of mood disorders. PMID: 26975259 [PubMed] (Source: Acta Neuropsychiatrica)



Dysregulation of ion fluxes in bipolar affective disorder.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Grunze HC, Langosch J, Normann C, Rujescu D, Amann B, Waiden J Abstract Bipolar disorder has attracted numerous research from different neurobiological angles. This review will summarize selected findings focusing on the role of disturbed transmem-braneous ion fluxes. Several mood stabilizers exhibit a distinct profile including effects on sodium, calcium and potassium conductance. In summary, some decisive mechanisms of action as calcium antagonism and modulation of potassium currents may play a crucial role in the success of any given mood stabilizer in bipolar disorder. PMID: 26975258 [PubMed] (Source: Acta Neuropsychiatrica)



Epidemiology and pathobiology of bipolar disorder, and their exploration within a complete catchment area population.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Scully PJ, Owens JM, Kinsella A, Waddington JL Abstract Epidemiological and pathobiological findings in bipolar disorder [BP] have often been limited by selection bias and lack of epidemiological representativeness. In a rural, circumscribed catchment area, 'all' patients with BP were identified and assessed. On preliminary analysis, morbid risk [MR] for BP over the area as a whole was 5.0 ± 0.6/1000. The distribution of MR for BP over geographical subregions showed no significant deviation from a statistical model for random occurrences in space by place at birth, in contrast to schizophrenia [SZ], and varied only modestly among males by place at onset. These results imply different etiological factors acting in BP in comparison with SZ, particularly with regard to the r...



Acute tryptophan depletion in bipolar disorders; literature review and directives for further research.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Sobczak S, Honig A, Riedel WJ Abstract Serotonin (5-HT) has been implicated in the pathophysiology of bipolar disorders. Acute tryptophan depletion (ATD), which decreases serotonergic turnover, is an established paradigm to study serotonergic vulnerability in affective disorders. Literature on the application of ATD as a research tool in bipolar patients is limited to three studies, which revealed inconsistent results on mood modification. These inconsistencies may be attributed to differences in methodological procedures and / or characteristics of included patients. Patient selection, methodological aspects and procedures of these studies are critically considered and recommendations given. A research protocol to test the 5-HT vulnerability in bipolar disorder is propose...



Genetics of bipolar disorders.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: Souery D, Massat I, Mendlewicz J Abstract Advances towards the understanding of the etiological mechanisms involved in mood disorders provide interesting yet diverse hypotheses and promising models. In this context, molecular genetics has now been widely incorporated into genetic epidemiological research in psychiatry. Affective disorders and, in particular, bipolar affective disorder (BPAD) have been examined in many molecular genetic studies which have covered a large part of the genome, specific hypotheses such as mutations have also been studied. Most recent studies indicate that several chromosomal regions may be involved in the aetiology of BPAD. Other studies have reported the presence of anticipation in BPAD. This phenomenon describes the increase in clinical sever...

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History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first‐treatment bipolar I disorder

Fri, 18 Mar 2016 00:00:00 +0100

ConclusionsNeurocognitive impairments were present in FT BD‐I, and were not explained by history of psychosis or number of previous psychotic or depressive episodes. There were indications that executive function could be associated with number of previous manic episodes. (Source: Bipolar Disorders)



Is it time for immunopsychiatry in psychotic disorders?

Fri, 18 Mar 2016 00:00:00 +0100

Conclusions: Specific therapeutic approaches targeting immune pathways may lead the way to novel personalized medical interventions, improvement of quality of life and average life expectancy of psychiatric patients, if not even prevent mood episodes and psychotic symptoms. (Source: Psychopharmacology)



Pharmacological targeting of redox regulation systems as new therapeutic approach for psychiatric disorders: a literature overview

Fri, 18 Mar 2016 00:00:00 +0100

Publication date: Available online 16 March 2016 Source:Pharmacological Research Author(s): Stefania Schiavone, Luigia Trabace Redox dysregulation occurs following a disequilibrium between reactive oxygen species (ROS) producing and degrading systems, i.e. mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and nitric oxide synthase (NOS) on one hand and the principal antioxidant system, the glutathione, on the other hand. Increasing recent evidence points towards a pathogenetic role of an altered redox state in the development of several mental disorders, such as anxiety, bipolar disorders, depression, psychosis, autism and post-traumatic stress disorders (PTSD). In this regard, pharmacological targeting of the redox state regulating systems in the brain has bee...



Anti-NMDAR antibodies in new-onset psychosis. Positive results in an HIV-infected patient

Fri, 18 Mar 2016 00:00:00 +0100

This study shows that patients presenting with clinically incomplete forms of anti-NMDAR encephalitis, with predominant or isolated psychiatric symptoms, can remain undetected if no ancillary tests are performed. To improve patient diagnosis and treatment of individuals with a first psychotic episode, more detailed neurological examinations might be needed. Further studies are required to better clarify the role of NSAs in the neuropsychiatric effects of HIV infection. (Source: Brain, Behavior, and Immunity)



Brain stem as a target site for the metabolic side effects of olanzapine

Fri, 18 Mar 2016 00:00:00 +0100

Olanzapine, an atypical antipsychotic, is widely prescribed for the treatment of schizophrenia and bipolar disorder despite causing undesirable metabolic side effects. A variety of mechanisms and brain sites have been proposed as contributors to the side effects; however, the role of the dorsal motor nucleus of the vagus nerve (DMV), which plays a crucial role in the regulation of subdiaphragmatic organs and thus governs energy and glucose homeostasis, is largely unknown. Identifying the effect of olanzapine on the excitability of DMV neurons in both sexes is thus crucial to understanding possible underlying mechanisms. Whole cell patch-clamp electrophysiological recordings were conducted in stomach- and liver-related DMV neurons identified with retrograde viral tracers and in random DMV n...

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The Truth About Gay Men and Depression

Thu, 17 Mar 2016 22:06:50 +0100

It's time to reveal the truth and I'm just going to say it: gay men and depression coexist. Dark, unfathomable, or uneasy, it's just the truth. I realized I was depressed when I was 12 years old. My parents had divorced, I had trouble making friends at school and my mood felt as heavy as the fog that lays over the city of San Francisco where I grew up. I didn't want to get out of bed and life seemed entirely different than the happy childhood I once knew. Life before depression was idealistic. I enjoyed creative arts and running. I also had big dreams to become an actor in New York City. My friends knew me as the outgoing, sarcastic, fun-loving kid who loved to give everyone hugs and sweet compliments. Once depression hit, I became serious and relentless to become the best damn performer, ...



Key differences found between patients with bipolar I, bipolar II

Thu, 17 Mar 2016 19:22:57 +0100

Second-generation antipsychotic use is associated with a previous incidence of psychiatric hospitalization in patients with bipolar disorder I but not in those with bipolar II, a study by Dr. Dong... (Source: Clinical Psychiatry News)



Examination of a four-step treatment algorithm for postpartum psychosis

Thu, 17 Mar 2016 13:33:17 +0100

Bergink and colleagues designed a four-step algorithm and examined outcomes of 64 mothers (mean age: 31.9) diagnosed with PPP via the Structured Clinical Interview for DSM Disorders (SCID-I), Patient Edition. Participants were recruited between 2005 and 2011 from a psychiatric inpatient unit in the Netherlands specifically for postpartum patients with severe psychopathology. A psychiatrist (1 of 2 study authors) evaluated participants weekly during admission and 9 months post partum. Clinical remission was defined as the absence of psychotic, manic and depressive symptoms for … (Source: Current Awareness Service for Health (CASH))



Intrinsic defect-mediated conduction and resistive switching in multiferroic BiFeO3 thin films epitaxially grown on SrRuO3 bottom electrodes

Thu, 17 Mar 2016 13:08:17 +0100

We report the impact of intrinsic defects in epitaxial BiFeO3films on charge conduction and resistive switching of Pt/BiFeO3/SrRuO3capacitors, although the BiFeO3films show very similar ferroelectric domain types probed by piezoresponse force microscopy.Capacitors with p-type Bi-deficient and n-type Bi-rich BiFeO3films exhibit switchable diode and conventional bipolar resistive switching behaviors, respectively. Both the capacitors show good retention properties with a high ON/OFF ratio of >100 in Bi-deficient films and that of >1000 in Bi-rich films. The present investigation advances considerably understanding of interface control through defect engineering of BiFeO3thin films for non-volatile memory application. (Source: Applied Physics Letters)



The treatment of magnetic buoyancy in flux transport dynamo models

Thu, 17 Mar 2016 00:00:00 +0100

Publication date: Available online 16 March 2016 Source:Advances in Space Research Author(s): Arnab Rai Choudhuri, Gopal Hazra One important ingredient of flux transport dynamo models is the rise of the toroidal magnetic field through the convection zone due to magnetic buoyancy to produce bipolar sunspots and then the generation of the poloidal magnetic field from these bipolar sunspots due to the Babcock–Leighton mechanism. Over the years, two methods of treating magnetic buoyancy—a local method and a non-local method—have been used widely by different groups in constructing 2D kinematic models of the flux transport dynamo. We review both these methods and conclude that neither of them is fully satisfactory—presumably because magnetic buoyancy is an inherently 3D process. We ...

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Effects of carbamazepine on cortisol levels and behavioral responses to stress in the fish Jenynsia multidentata

Thu, 17 Mar 2016 00:00:00 +0100

The objective of this study was to analyze if CBZ modifies scototaxis and shoaling behaviors and/or whole-body cortisol levels of the one-sided livebearing fish Jenynsia multidentata under stress condition. Female adults of J. multidentata were exposed to 0, 10, 50 and 200μgCBZ/L during 14days. After CBZ exposure, fish were subjected to restraint stress during 15min. Control animals were not exposed to CBZ or stress. In the light/dark preference test (scototaxis), the individuals under acute restraint stress (without CBZ) exhibited a significant increase in the mean speed and in the time spent both in the light compartment and in the bottom of the tank with respect to controls. They also showed a tendency to stay longer frozen in the light compartment. Fish exposed to 10 and 50μgCBZ/L sh...



Impact of specific phobia on the risk of onset of mental disorders: a 10‐year prospective‐longitudinal community study of adolescents and young adults

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionThis study provides strong evidence that specific phobia is an early onset disorder predicting the subsequent onset of a range of disorders. Future studies should examine the underlying mechanisms and the potential of using specific phobia as a target for prevention of subsequent psychopathology. (Source: Depression and Anxiety)



Perceived Stress and Hair Cortisol: Differences in Bipolar Disorder and Schizophrenia

Thu, 17 Mar 2016 00:00:00 +0100

(Source: Psychoneuroendocrinology)



Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain

Thu, 17 Mar 2016 00:00:00 +0100

Conclusion: Metamizole, dexketoprofen and meloxicam show antinociceptive effect with different duration of action on CRD-induced visceral pain model. This condition can be explained due to different chemical structures and different mechanisms which play a role in modulation of pain. (Source: Indian Journal of Pharmacology)



The Bidirectional Associations Between Psychotic Experiences and DSM-IV Mental Disorders.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: While temporally primary psychotic experiences are associated with an elevated risk of several subsequent mental disorders, these data show that most mental disorders are associated with an elevated risk of subsequent psychotic experiences. Further investigation of the underlying factors accounting for these time-order relationships may shed light on the etiology of psychotic experiences. PMID: 26988628 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

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Enrollment and Service Use Patterns Among Persons With Severe Mental Illness Receiving Expedited Medicaid on Release From State Prisons, County Jails, and Psychiatric Hospitals.

Wed, 16 Mar 2016 17:04:02 +0100

CONCLUSIONS: Expediting Medicaid benefits for persons with severe mental illness was associated with increased enrollment and outpatient mental health service use in the 90 days after release from state prisons, county jails, and psychiatric hospitals in Washington State. PMID: 26975523 [PubMed - as supplied by publisher] (Source: Psychiatric Services)



Expedited Medicaid Enrollment, Mental Health Service Use, and Criminal Recidivism Among Released Prisoners With Severe Mental Illness.

Wed, 16 Mar 2016 17:04:02 +0100

CONCLUSIONS: Expediting Medicaid was associated with increased Medicaid enrollment and both mental health and general medical service use, but study findings strongly suggest that rather than relying on indirect spillover effects from Medicaid to reduce criminal recidivism, advocates and policy makers would better address the needs of offenders with severe mental illness through direct interventions targeted at underlying causes of recidivism. PMID: 26975522 [PubMed - as supplied by publisher] (Source: Psychiatric Services)



Allergan Announces U.S. Availability of VRAYLAR(TM) (cariprazine) for Treatment of Bipolar Mania and Schizophrenia in Adults

Wed, 16 Mar 2016 16:38:38 +0100

DUBLIN, March 16, 2016 -- (Healthcare Sales & Marketing Network) -- Allergan plc (AGN), a leading global pharmaceutical company, announced today that VRAYLAR™ (cariprazine), a once-daily oral atypical antipsychotic, is now available by prescription in pha... Biopharmaceuticals, Product LaunchAllergan, VRAYLAR, cariprazine, Bipolar Mania, Schizophrenia (Source: HSMN NewsFeed)



Demi Lovato Is Four Years Sober And That's Something To Celebrate

Wed, 16 Mar 2016 15:03:15 +0100

Demi Lovato's time spent in the "La La Land" machine has not been without its struggles. But the "Confident" singer has made her painful experiences into something beautiful, channeling her hardships into music. Now, Lovato is stopping to reflect on a major accomplishment: her sobriety.  On Tuesday, the former Disney star revealed that it's her four-year sober anniversary. "This last year I experienced so much life and too much death... But I made it through... Sober. #4Years #GodsWill ," she tweeted.  This last year I experienced so much life and too much death... But I made it through... Sober. #4Years #GodsWill — Demi Lovato (@ddlovato) March 15, 2016 Days before, Lovato, referencing her sobriety, wrote that "anything is possible," before quoting the Tall Heights s...



So Your Doctor Prescribed Lamical. Will You...

Wed, 16 Mar 2016 00:00:00 +0100

If you're taking Lamictal for bipolar disorder or for epilepsy, you may be worried that it will cause you to gain or lose weight. Learn the facts. (Source: About.com Bipolar Disorder)

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Patients' Experiences with Lithium

Wed, 16 Mar 2016 00:00:00 +0100

Members of the About Bipolar Disorder Forum Community share their experiences with the medication Lithium, which is used as a mood stabilizer in treating manic-depressive illness. (Source: About.com Bipolar Disorder)



The Difference Between Congruent and Incongruen...

Wed, 16 Mar 2016 00:00:00 +0100

Symptoms are mood-incongruent if they are not consistent with your mood or are at odds with current circumstances.They're mood-congruent if they are. (Source: About.com Bipolar Disorder)



What is the definition of suicidal ideation?

Wed, 16 Mar 2016 00:00:00 +0100

Suicidal ideation means thinking about suicide or wanting to take your own life. Here we explain what may lead to suicidal thoughts and five tips for kids. (Source: About.com Bipolar Disorder)



Understanding Your Bipolar Medications

Wed, 16 Mar 2016 00:00:00 +0100

(Source: About.com Mental Health)



What Is Bipolar Disorder?

Wed, 16 Mar 2016 00:00:00 +0100

(Source: About.com Mental Health)

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The direct and indirect effects of lurasidone monotherapy on functional improvement among patients with bipolar depression: results from a randomized placebo-controlled trial

Wed, 16 Mar 2016 00:00:00 +0100

The objective of this study was to assess the independent, direc... (Source: International Journal of Bipolar Disorders)



Biological rhythms are independently associated with quality of life in bipolar disorder

Wed, 16 Mar 2016 00:00:00 +0100

Evidence suggests that patients with bipolar disorder (BD) experience biological rhythm disturbances; however, no studies have examined the impact of this disruption on quality of life (QOL). The aim of this s... (Source: International Journal of Bipolar Disorders)



Consider second-generation antipsychotics for the management of mixed states in bipolar disorder

Wed, 16 Mar 2016 00:00:00 +0100

Abstract The diagnosis and treatment of mixed states in bipolar disorder can be challenging. The mainstay of treatment is antipsychotic therapy (± a mood stabilizer), with second-generation antipsychotics emerging as the treatment of choice. When medication fails or cannot be used, electroconvulsive therapy may be effective. (Source: Drugs and Therapy Perspectives)



Monitoring of alcohol consumption in primary care among adults with bipolar disorder: a cross-sectional and retrospective cohort study

Wed, 16 Mar 2016 00:00:00 +0100

Screening for alcohol use disorders is an important priority in the healthcare of people with bipolar disorder, incentivised in UK primary care since 2011, through the Quality and Outcomes Framework (QOF). The extent of alcohol monitoring in primary care, and impact of QOF, is unknown. The aim was to examine recording of alcohol consumption in primary care. (Source: Journal of Affective Disorders)



Neuroinflammation: A Therapeutic Target of Cotinine for the Treatment of Psychiatric Disorders?

Tue, 15 Mar 2016 12:22:02 +0100

Authors: Echeverria V, Alex Grizzell J, Barreto GE Abstract Neuroinflammation is a common characteristic of several mental health conditions such as major depression, bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia (SCHZ). Inflammatory processes trigger and/or further deteriorate mental functions and are regarded as targets for therapeutic drug development. Cotinine is an alkaloid present in tobacco leaves and the main metabolite of nicotine. Cotinine is safe, non-addictive and has pharmacokinetic properties adequate for therapeutic use. Research has shown that cotinine has antipsychotic, anxiolytic, and antidepressant properties and modulates the serotonergic, cholinergic and dopaminergic systems. Consistent with the modulation of these neurotransmitter s...

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Combined Use of High Radiofrequency Disk Ablation, Annulus Modulation, and Manual Nucleotomy in a Patient with Extruded Disk Herniation

Tue, 15 Mar 2016 00:00:00 +0100

This report describes a successful case involving the use of mechanical decompression in conjunction with radiofrequency ablation to treat a patient with pain and neurological deficits due to an extruded disk hernia. Case ReportA 43‐year‐old male had magnetic resonance imaging (MRI) demonstrating an extruded disk herniation in the left foraminal region, compression at the left spinal nerve root, and obliteration of the left foraminal entrance of the L5‐S1 distribution. In the operating room, sufficient disk material was removed using grasping forceps, and then, the Disc‐FX system with a Trigger‐Flex probe (Elliquence, Baldwin, NY, U.S.A.) was inserted. Modulation of the annulus was performed in bipolar hemo mode, and nucleus ablation was conducted in bipolar turbo mode within a 1...



Decreased Brain-Derived Neurotrophic Factor (BDNF) in Older Adults with Bipolar Disorder

Tue, 15 Mar 2016 00:00:00 +0100

The objective of this study was to examine whether euthymic late-life BD patients have lower BDNF levels than healthy comparators. (Source: The American Journal of Geriatric Psychiatry)



Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients

Tue, 15 Mar 2016 00:00:00 +0100

Emotional dysregulation in subjects with attention deficit and hyperactivity disorder (ADHD) is a topic of growing interest among clinicians and researchers. The present study aims at investigating components of emotional dysregulation in adults ADHD compared to subjects suffering from bipolar disorder (BD). (Source: Journal of Affective Disorders)



Coping strategies and real-world functioning in bipolar disorder

Tue, 15 Mar 2016 00:00:00 +0100

Bipolar disorder (BD) patients encounter significant life adversity, which has contributed to bipolar disorder being a leading cause of disability worldwide. Studies suggest BD patients have more maladaptive coping strategies, some of which can impact their illness course. Yet research on which coping strategies most influence disability is lacking. Such research could inform cognitive-behavioral targets to improve functional outcomes. Thus, we sought to identify relations between coping strategies and real-world function in BD. (Source: Journal of Affective Disorders)



DGKH genetic risk variant influences gene expression in bipolar affective disorder

Tue, 15 Mar 2016 00:00:00 +0100

DGKH is a replicated risk gene of bipolar disorder (BD). However, the pathophysiological role of the coded protein, diacylglyerol kinase eta, remains elusive. (Source: Journal of Affective Disorders)

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A negative double-blind controlled trial of sequential bilateral rTMS in the treatment of bipolar depression

Tue, 15 Mar 2016 00:00:00 +0100

To explore the therapeutic benefit of sequential bilateral repetitive transcranial magnetic stimulation (rTMS) in the treatment of bipolar depression (Source: Journal of Affective Disorders)



Impulsivity Predicts the Onset of DSM-IV-TR or RDC Hypomanic and Manic Episodes in Adolescents and Young Adults with High or Moderate Reward Sensitivity

Tue, 15 Mar 2016 00:00:00 +0100

A growing body of research suggests that bipolar disorders (BD) are associated with high impulsivity. Using a multi-method approach, the current study provided the first examination of the hypothesis that impulsivity would prospectively predict shorter time to onset of DSM-IV-TR or RDC hypomanic or manic episodes in a sample selected based on reward sensitivity, a biobehavioral trait shown to predict onset and course of BD. (Source: Journal of Affective Disorders)



Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Kalkman HO, Feuerbach D Abstract The clinical development of selective alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonists has hitherto been focused on disorders characterized by cognitive deficits (e.g., Alzheimer's disease, schizophrenia). However, α7 nAChRs are also widely expressed by cells of the immune system and by cells with a secondary role in pathogen defense. Activation of α7 nAChRs leads to an anti-inflammatory effect. Since sterile inflammation is a frequently observed phenomenon in both psychiatric disorders (e.g., schizophrenia, melancholic and bipolar depression) and neurological disorders (e.g., Alzheimer's disease, Parkinson's disease, and multiple sclerosis), α7 nAChR agonists might show beneficial effects in these central nervous system dis...



Surgical treatment for childhood obstructive sleep apnoea: Cold-knife tonsillar dissection versus bipolar radiofrequency thermal ablation.

Tue, 15 Mar 2016 00:00:00 +0100

CONCLUSION: In the treatment of childhood obstructive sleep apnoea syndrome, both extracapsular surgery using cold scalpel and bipolar radiofrequency tunnelling techniques are safe. Likewise, results as to resolution of the syndrome show no statistically significant differences. PMID: 26992775 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)



From Stressed to Inner Peace to Flourishing

Mon, 14 Mar 2016 21:52:06 +0100

Neuroscience has become quite adept at mapping the brain and they can actually measure your level of inner peace. And here's what they found. We are at our creative cognitive and emotional best when we are at peace. By simply accentuating qualities of a positive peaceful attitude you produce positive changes in your brain that enable you to flourish. A peaceful state of mind increases gray matter, making your mind stronger and able to works faster. It improves memory, attention, and your capacity to learn. You process emotions better, enabling you to feel vibrant and inspired, but not so emotionally charged that you become manic, chaotic, or rigid. You are much abler to sustain your focus in a high-stress environment. You achieve greater interpersonal resonance and attuned communic...

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9 Psychiatric Conditions That Share Symptoms...

Mon, 14 Mar 2016 00:00:00 +0100

The list of psychiatric conditions with symptoms similar to those of bipolar disorder is rather long. To further complicate the picture, most of these disorders can also occur with bipolar disorder. Here is a review of the major conditions that fall into this category. (Source: About.com Bipolar Disorder)



What Are the Warning Signs of Suicide in...

Mon, 14 Mar 2016 00:00:00 +0100

These red flags are the warning signs that a person may be planning suicide. People with bipolar disorder or manic depression may become suicidal. (Source: About.com Bipolar Disorder)



If You're Bipolar, You Likely Have Lots of...

Mon, 14 Mar 2016 00:00:00 +0100

Nightmares and night terrors are commonly experienced by people with bipolar disorder. Bipolar children are especially prone to night terrors. Page 2. (Source: About.com Bipolar Disorder)



Automatic Detection of Social Rhythms in Bipolar Disorder

Mon, 14 Mar 2016 00:00:00 +0100

Conclusions Automatic smartphone sensing is a feasible approach for inferring rhythmicity, a key marker of wellbeing for individuals with BD. (Source: Journal of the American Medical Informatics Association)

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Exercise in bipolar patients: A systematic review

Mon, 14 Mar 2016 00:00:00 +0100

Sedentary lifestyle is frequent in psychiatric disorders, however the directions of this association and benefits of physical activity are unclear. This is a systematic review about exercise in patients with bipolar disorder. (Source: Journal of Affective Disorders)



Six-session caregiver psychoeducation on bipolar disorder: Does it bring benefits to caregivers?

Mon, 14 Mar 2016 00:00:00 +0100

CONCLUSION: A six-session caregiver psychoeducational intervention on bipolar disorder did not bring benefits to caregiver's health. A longer longitudinal follow-up study would be crucial to see whether there were differences in degree of burden, perceived self-esteem and quality of life over time in caregivers. PMID: 26975694 [PubMed - as supplied by publisher] (Source: The International Journal of Social Psychiatry)



Lithium treatment in affective disorders: The significance of strongly elevated erythrocyte choline levels.

Sun, 13 Mar 2016 16:40:02 +0100

Authors: Flentge F, Slooff CJ Abstract In manic-depressive patients treated with lithium salts the transport of choline over the erythrocyte membrane is strongly inhibited, resulting in dramatically increased erythrocyte choline levels (for review see ref. 1). Whether or not there is a relationship between this effect and treatment response is not clear. Data on this issue are scarce possibly because the measurement of treatment response in lithium prophylaxis is very difficult and time consuming. Also the effect on erythrocyte choline is specific for lithium and not for manic-depressive illness. We will address here the question of a possible relation between erythrocyte choline and clinical effects of lithium. PMID: 26965357 [PubMed] (Source: Acta Neuropsychiatrica)



The rapid suicide protection of mood stabilizers on patients with bipolar disorder: a nationwide observational cohort study in taiwan - Tsai CJ, Cheng C, Chou PH, Lin CH, McInnis MG, Chang CL, Lan TH.

Sun, 13 Mar 2016 03:34:31 +0100

BACKGROUND: The suicide rate is high among bipolar disorder (BD) patients. Previous studies have focused on the anti-suicidal effect of long-term treatment with mood stabilizers but less on the immediate preventive effects of interventions. The aim of the ... (Source: SafetyLit)



Can Lamictal (Lamotrigine) Cause or Treat...

Sun, 13 Mar 2016 00:00:00 +0100

Lamictal (lamotrigine) is prescribed for seizure disorders and bipolar disorder as a mood stabilizer, but does it treat or cause anxiety? (Source: About.com Bipolar Disorder)

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Top 5 Groups of Medications Used to Treat Mania...

Sun, 13 Mar 2016 00:00:00 +0100

Bipolar disorder is usually treated with medications for depression and mania. Here's an overview of the drugs used to treat mania and hypomania. (Source: About.com Bipolar Disorder)



Can Kindling Contribute to Certain Types of...

Sun, 13 Mar 2016 00:00:00 +0100

Learn about the kindling theory in bipolar disorder: the theory's origins, the most recent research on it, and the implications for treatment. (Source: About.com Bipolar Disorder)



Oliver James is wrong to blame parents for their children’s mental illness | Deborah Orr

Sat, 12 Mar 2016 08:00:11 +0100

To completely discount inheritability of faulty genes when analysing even diseases such as schizophrenia or bipolar disorder beggars beliefThe psychologist Oliver James has for many years been a part of the cultural landscape, writing best-selling books, making television programmes, contributing articles to newspapers and generally offering his views. As a practicing psychotherapist of many years’ standing, he has good reason to believe that he has important insights to offer. Related: Genetic denialism is unhelpful - genes play a role in who we are Continue reading... (Source: Guardian Unlimited Science)



Manic episode, thyroid gland function and lithium.

Sat, 12 Mar 2016 04:45:03 +0100

Authors: Foeken K, van de Wetering BJ Abstract This paper addresses the issue of (recurrent) mania in relation to an increased T4-value, whether or not influenced by lithium. Lithium has an anti-TSH-effect on the thyroid gland by inhibiting the intracellular enzyme adenylate cyclase. This might cause hypothyroidism. Moreover, lithium is also known to have a direct stabilizing effect on (behavioral manifestations) of dopamine receptor supersensitivity. The hypothesis regarding the relation between thyroid function and affective disturbances is that the altered thyroid function may cause a change in the availability of the central dopamine receptors. Dopamine is known to be able to cause a manic state. TSH and TRH are also involved in this mechanism. It is, therefore, very likely tha...