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MedWorm: Hormone Replacement Therapy provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Hormone Replacement Therapy category.

Last Build Date: Tue, 29 Mar 2016 05:11:22 +0100


Mp60-14 urinary incontinence in a rat model of surgical menopause: effects of gonadal hormone replacement therapy

Mon, 28 Mar 2016 19:24:08 +0100

Urinary dysfunction in menopausal women has been related to decreased levels of ovarian hormones. However, steroid hormone replacement therapy has generated controversial outcomes. The aim of this study was to determine whether ovariectomy (OVX) with or without gonadal hormone replacement therapy (HRT) induces behavioral signs of urinary dysfunction in sexually mature female rats. (Source: The Journal of Urology)

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Self-reported experiences of discrimination and inflammation among men and women: The multi-ethnic study of atherosclerosis.

Sun, 27 Mar 2016 22:00:00 +0100

Conclusions: The association between discrimination and inflammation varied by gender and marker of inflammation. These findings highlight the complex relationship between discrimination and cardiovascular disease (CVD) risk and point to areas in need of further research. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: Health Psychology)

Hypogonadism and sex steroid replacement therapy in girls with Turner syndrome

Wed, 23 Mar 2016 23:00:00 +0100

Turner syndrome (TS) is the most common example of hypergonadotropic hypogonadism resulting from gonadal dysgenesis. Most patients present delayed, or even absent, puberty. Premature ovarian failure can be expected even if spontaneous menarche occurs. Laboratory markers of gonadal dysgenesis are well known. The choice of optimal hormone replacement therapy in children and adolescents remains controversial, particularly regarding the age at which therapy should be initiated, as well as the dose and route of estrogen administration. (Source: Journal of Pediatric and Adolescent Gynecology)

Prepubertal Gynecomastia Due to Indirect Exposure to Nonformulary Bioidentical Hormonal Replacement Therapy: A Case Report.

Tue, 22 Mar 2016 14:16:01 +0100

CONCLUSION: Indirect exposure to nonformulary hormonal replacement in our case report was an etiologic factor in the development of prepubertal gynecomastia. This novel estrogen exposure source has important implications in the differential diagnosis of prepubertal gynecomastia and potential adverse effects secondary to precocious hormonal exposure. PMID: 26995893 [PubMed - in process] (Source: Journal of Reproductive Medicine)

Id: 20: hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial thrombophilia

Mon, 21 Mar 2016 23:00:00 +0100

Conclusion After excluding antecedent cancer, 24/148 women (16%) had ET before PE, and TT was taken by 8/121 (7%) men. PE is an important complication of TT in men and ET in women, in part reflecting an interaction between familial and acquired thrombophilia and exogenous hormone use. (Source: Journal of Investigative Medicine)

[A woman with a pure seminoma and a contralateral intratubular germinal neoplasm. A case report].

Wed, 16 Mar 2016 23:00:00 +0100

DISCUSSION: The importance of early diagnosis is discussed, highlighting the consequences of misdiagnosis, and question whether these patients have been adequately treated in the past. The risk of malignant transformation of an undescended testicle increases with age, thus gonadectomy should be performed after puberty, and in some cases hormone replacement therapy. PMID: 26997294 [PubMed - as supplied by publisher] (Source: Cirugia y Cirujanos)

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Evaluation of the Biological Activity of Opuntia ficus indica as a Tissue‐ and Estrogen Receptor Subtype‐Selective Modulator

Mon, 14 Mar 2016 00:00:00 +0100

This study was aimed at elucidating the molecular mechanisms underlying the SERM properties of the extract of Korean‐grown Opuntia ficus‐indica (KOFI). The KOFI extract induced estrogen response element (ERE)‐driven transcription in breast and endometrial cancer cell lines and the expression of endogenous estrogen‐responsive genes in breast cancer cells. The flavonoid content of different KOFI preparations affected ERE‐luciferase activities, implying that the flavonoid composition likely mediated the estrogenic activities in cells. Oral administration of KOFI decreased the weight gain and levels of both serum glucose and triglyceride in ovariectomized (OVX) rats. Finally, KOFI had an inhibitory effect on the 17β‐estradiol‐induced proliferation of the endometrial epithelium i...

Hot flush menopause misery could be over due to new wonder pill

Sun, 13 Mar 2016 11:32:38 +0100

Developed by a team at Imperial College, London, the new treatment works completely differently from hormone replacement therapy (HRT). The ‘very important’ advance could improve millions of lives. (Source: the Mail online | Health)

New treatment for hot flushes could improve lives of millions

Sun, 13 Mar 2016 11:28:40 +0100

Some women can experience up to 30 hot flushes in a 24-hour period, seriously disrupting their sleep, relationships and work (Source: Telegraph Health)

The effects of growth hormone on clinical outcomes after frozen–thawed embryo transfer

Fri, 11 Mar 2016 00:00:00 +0100

Conclusion Simultaneous administration of rhGH with HRT could improve clinical outcomes after FET by increasing endometrial blood perfusion and expression of cytokines related to endometrial receptivity. (Source: International Journal of Gynecology and Obstetrics)

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Treatment for osteoporosis in people with ß-thalassaemia.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: There is evidence to indicate an increase in bone mineral density at the femoral neck, lumbar spine and forearm after administration of bisphosphonates and at the lumbar spine and hip after zinc sulphate supplementation. The authors recommend that further long-term randomised control trials on different bisphosphonates and zinc supplementation therapies in people with beta-thalassaemia and osteoporosis are undertaken. PMID: 26964506 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Talc and ovarian cancer: what the most recent evidence shows

Tue, 08 Mar 2016 10:30:00 +0100

Conclusion This case-control study aimed to investigate the association between talc use and ovarian cancer. The researchers found a significant link between genital talc use and ovarian cancer – an increase in risk of a third, compared with no use. However, the study has important limitations and is not able to prove direct cause and effect. Although this was a case-control study that made use of data collected as part of an ongoing cohort study, talc use only seems to have been assessed after cancer diagnosis.  The study says that, "subjects were personally interviewed about potential ovarian cancer risk factors that occurred more than one year before diagnosis". There is therefore a possibility that women recalled their talc use inaccurately, leading to misclassification...

Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy.

Sat, 05 Mar 2016 11:14:02 +0100

We present a 71-year-old woman with hypopituitarism without any hypothalamic/pituitary abnormalities as assessed by magnetic resonance imaging. She presented with edema, abducens palsy, and elevated levels of lactate dehydrogenase and soluble interleukin-2 receptor. Provocative testing showed that the peaks of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone and adrenocorticotropic hormone were evoked to normal levels by simultaneous administration of luteinizing hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone, but the responses of these four pituitary hormones showed a delayed pattern. She was diagnosed with IVLBCL with cerebrospinal invasion by pathological findings of the bone marrow, skin, and cerebrospinal flui...

Sex hormones and the risk of keratinocyte cancers among women in the United States: A population‐based case‐control study

Thu, 03 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)

Factors Associated with Biomarkers of Systemic Inflammation

Thu, 03 Mar 2016 00:00:00 +0100

Conclusions: Although the associations varied by biomarker, the factors having the greatest number of significant associations (P ≤ 0.05) with the inflammation biomarkers were age, BMI, dietary saturated fat, and EPA+DHA omega-3 fatty acids. Impact: Our results suggest that potential confounders in epidemiologic studies assessing associations with inflammation biomarkers vary across specific biomarkers. Cancer Epidemiol Biomarkers Prev; 25(3); 521–31. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)

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Gynaecological surveillance in high risk women.

Wed, 02 Mar 2016 16:12:02 +0100

Authors: Dilley J, Gentry-Maharaj A, Menon U Abstract Increasing availability of genetic testing and falling costs of the tests suggests that growing numbers of unaffected women will be identified worldwide who are at increased risk of gynaecological malignancies. The challenge in those identified is to prevent and detect the disease early without causing significant harm. Currently surgery remains the cornerstone of management. Most women undergoing surgery do not report a significant deterioration of their physical and mental health-related quality of life (1). However the resulting premature menopause is associated with decrease in sexual functioning and vasomotor symptoms even in women on hormone replacement therapy (HRT)(2)(3). As a result there is a continued effort to develo...

Dealing with premature menopause in women at high-risk for hereditary genital and breast cancer.

Wed, 02 Mar 2016 16:12:02 +0100

Authors: Nappi RE, Cassani C, Rossi M, Zanellini F, Spinillo A Abstract Risk-reducing salpingo-oophorectomy (RRSO) is the mainstay of ovarian cancer prevention in BRCA mutation carriers. However, premature menopause exerts many short and long-term consequences on the individual health that are preventable with a tailored approach. Even though our level of knowledge on BRCA1/2 mutation carriers is still in its infancy, the basic principles governing the management of menopausal symptomatology and the prevention of diseases should be applied, including the use of hormone replacement therapy (HRT), approximately until the age of 50. Indeed, short-term HRT significantly ameliorate quality of life and symptoms associated to vulvo-vaginal atrophy, without displaying an adverse effect on ...

Talcum Powder: Just How Much Risk Does It Pose?

Tue, 01 Mar 2016 02:38:12 +0100

Johnson & Johnson is a trusted name whose baby powder has long been a staple of many homes. The powder absorbs excess moisture and protects skin from chafing and irritating rashes. Women in particular use it as a part of feminine hygiene. Now we are being told that this household item could be linked to cancer. Johnson & Johnson just lost a huge lawsuit brought by the family of a woman who died of ovarian cancer after years of using the product. The decision wasn't actually based on hard evidence of a known link between talc and ovarian cancer, leading to a lot of confusion for consumers. Baby powder's main ingredient is talc -- a natural product made of magnesium, silicon, hydrogen and oxygen. In addition to baby powder, talc is found in a lot of cosmetic products. Talc baby powder wa...

Pseudoangiomatous Stromal Hyperplasia of the Breast: Multimodality Review With Pathologic Correlation

Mon, 29 Feb 2016 00:00:00 +0100

Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign breast condition. PASH is thought to be hormonally responsive, and it is usually identified in premenopausal and perimenopausal women. PASH may also be seen in postmenopausal woman on hormone replacement therapy (HRT). Approximately 53% of patients with PASH present with abnormalities on screening mammography, and 44% of patients with PASH present with palpable abnormalities. On imaging studies, PASH appears similar to fibroadenomas. On mammography, PASH is usually seen as a noncalcified, circumscribed mass. (Source: Current Problems in Diagnostic Radiology)

Abstract A43: Context-dependent growth effects of progestins in estrogen receptor-positive breast cancer patient-derived xenografts (PDX)

Mon, 29 Feb 2016 00:00:00 +0100

Conclusion: Progestins have mixed effects on breast cancer PDX tumor growth. Tumors that have high ER and PR and are highly estrogen-dependent are more likely to exhibit strong growth inhibition by progestins (both P4 and MPA). Tumors with mixed luminal/basal phenotype that have less ER and PR and are moderately estrogen-dependent are less likely to be progestin-inhibited. In tumors with low ER and PR but high AR content MPA can act as an AR agonist to stimulate growth. Tumor-specific downstream estrogen-dependent pathways such as Notch may indicate whether progestins are therapeutic. Additional tumors are needed to confirm these results with the long term goal of developing a molecular assay to define those tumors that may benefit from progestin treatment.Citation Format: Jessica Finlay-S...

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A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease

Sat, 27 Feb 2016 14:07:40 +0100

Conclusion: Duration of estrogen deficiency in postmenopausal state confers fibrosis risk among post‐menopausal women with NAFLD. This article is protected by copyright. All rights reserved. (Source: Hepatology)

Worsening migraines in women using HRT indicate increased risk of stroke

Thu, 25 Feb 2016 12:21:00 +0100

Worsening migraines in users of hormone replacement therapy is associated with an increased risk of ischaemic stroke, according to a new study. (Source: The Pharmaceutical Journal)

Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study [Epidemiology]

Tue, 23 Feb 2016 00:00:00 +0100

Conclusions Prolactin is not associated with a comprehensive panel of incident cardiovascular disease risk factors. Measurement of circulating prolactin levels in the community likely does not provide substantial insight into cardiometabolic risk. (Source: JAHA:Journal of the American Heart Association)

Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease.

Sat, 20 Feb 2016 10:15:03 +0100

Authors: Hu Z, Yang Y, Gao K, Rudd JA, Fang M Abstract Ovarian hormones, including progesterone (P4) and 17 β-estradiol (E2), have been shown to affect memory functions; however, the underlying mechanism whereby ovarian hormone replacement therapy may decrease the risk of Alzheimer's disease (AD) is currently unclear. The present study aimed to investigate the effects of P4 and E2 on spatial and learning memory in an ovariectomized rat model of AD. β-amyloid (Aβ) or saline were stereotaxically injected into the hippocampus of the rats and, after 1 day, ovariectomy or sham operations were performed. Subsequently, the rats were treated with P4 alone, E2 alone, or a combination of P4 and E2. Treatment with E2 and/or P4 was shown to improve the learning and memory functions of the r...

Pregnancy outcome after oocyte donation in patients with Turner's syndrome: Clinical experience and management.

Fri, 19 Feb 2016 10:55:03 +0100

Authors: Deligeoroglou E, Stergioti E, Dimopoulos KD, Karountzos V, Prapas Y Abstract Turner's syndrome (TS) is a chromosomal defect with partial or total absence of the X chromosome. Our objective is to report our experience in Greece with patients suffering from TS and trying to conceive; therefore, we present four patients with TS, who underwent In vitro fertilization (ICSI) with donor oocytes in order to get pregnant. Three out of four patients managed to conceive and bring pregnancy to completion. It was shown that patients diagnosed in childhood or adolescence with TS have the possibility to undergo hormone replacement therapy (HRT) and thus, secondary sexual characteristics as well as uterus of almost normal size can develop. Assisted reproduction techniques (ART), predomina...

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Worsening Migraine During HRT Tied to Increased Stroke Risk Worsening Migraine During HRT Tied to Increased Stroke Risk

Thu, 18 Feb 2016 22:04:50 +0100

Women who have worsening migraines while receiving hormone replacement therapy are at increased risk for ischemic stroke, new research suggests. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)

Abstract PD1-03: Cholesterol, cholesterol lowering medication use, and breast cancer outcomes in the BIG 1-98 study

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions:In the BIG 1-98 study investigating the use of tamoxifen, letrozole or their sequence as endocrine therapy in the adjuvant setting, use of cholesterol-lowering therapy at baseline was associated with beneficial tumor characteristics. The effects on clinical outcome need further investigation.Citation Format: Borgquist S, Giobbie-Hurder A, Ahern T, Garber JE, Colleoni M, Láng I, Debled M, Ejlertsen B, Coates AS, Goldhirsch A, Price KN, Gelber RD, Regan MM, Thürlimann B. Cholesterol, cholesterol lowering medication use, and breast cancer outcomes in the BIG 1-98 study. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr PD1-03. (Sou...

Abstract S6-03: Anastrozole versus tamoxifen for the prevention of loco-regional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in-situ (IBIS-II DCIS)

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions: To follow.Citation Format: Cuzick J, Forbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy C, von Minckwitz G, Eiermann W, Neven P, Stierer M, Holcombe C, Coleman RE, Jones LJ, Ellis I. Anastrozole versus tamoxifen for the prevention of loco-regional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in-situ (IBIS-II DCIS). [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr S6-03. (Source: Cancer Research)

Abstract P1-16-06: Luteolin inhibits progestin-dependent VEGF induction, stem-cell like characteristics, and tumor progression of human breast cancer cells

Thu, 18 Feb 2016 00:00:00 +0100

In this study, we tested the effects of luteolin, a flavonoid commonly found in fruits and vegetables, on proliferation of BT-474 and T47-D breast cancer cells and their P-dependent production of VEGF. Luteolin treatment (25-100 μM) for 24-48 h reduced in vitro tumor cell viability and induced apoptosis. Interestingly, treatment with a lower concentration of luteolin (10 μM) blocked the production of P-dependent VEGF, indicating that VEGF suppression precedes luteolin-mediated loss of cell viability. Furthermore, luteolin (20 mg/kg, i.p.) suppressed the growth of MPA-dependent T47-D human xenograft tumors in nude mice. Immunohistochemical analysis showed that luteolin reduced P-induced VEGF in tumor sections (p (Source: Cancer Research)

Abstract P4-10-08: Can a diagnosis of invasive breast cancer effectively motivate patients to follow healthy lifestyles?

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions: These data support the critical importance of providing education and recommendations about engaging in healthy behaviors by the clinical staff. The two behaviors that improved significantly in patients with invasive breast cancer are both addressed by the clinical staff at Walter Reed National Military Medical Center at the time of diagnosis: with nurse navigators providing education about proper BSE and physicians recommending discontinuation of HRT. Failure to significantly change other behaviors suggests that a diagnosis of breast cancer is not a sufficient motivating factor for the patient to adopt healthier lifestyle choices without provision of education and resources. Our data suggest a need for increased health-related behavioral counseling and support systems to succ...

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Abstract P5-08-31: Withdrawal of exogenous hormones affects prognostic multigene signature results in early luminal breast cancer

Thu, 18 Feb 2016 00:00:00 +0100

BackgroundEarly breast cancer (BC) outcomes are mainly estimated based on clinicopathological parameters and rarely include proliferation markers: (Ki-67), and multigene signatures (MGS), which are typically measured in tumors from resection specimens (RS). We believe that tumor proliferation can change within days of anti-estrogen use. However, little is known how proliferation changes after withdrawal of hormone replacement therapy (HRT) or oral anti-conception (OAC) after a core needle biopsy (CNB) shows BC. Hence, this study compares the Ki-67 labeling index and the MGS results in CNB and RS collected from a cohort of patients under OAC/HRT.Patients and MethodsThis retrospective study included consecutive women diagnosed with a grade 1-2, any pTN0-1, primary operable estrogen receptor-...

Abstract P5-17-04: Breast conserving surgery alone for ductal carcinoma in situ: Factors associated with increased risk of local recurrence

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions: Our data indicate that higher nuclear grade, narrower margin width, use of exogenous hormones, and smoking history may be associated with an increased risk of LR. The evaluation of these factors may be helpful when considering whether to use adjuvant RT or not for patients with DCIS.Citation Format: Recht A, Mele A, Mehta P, Brook A, Slanetz P, Sharma R. Breast conserving surgery alone for ductal carcinoma in situ: Factors associated with increased risk of local recurrence. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-17-04. (Source: Cancer Research)

HRT for elderly men could boost libido and make them happier

Wed, 17 Feb 2016 22:00:09 +0100

A 'landmark' new study has suggested that should consider taking hormone replacement therapy to boost their sex drive and improve their moods (Source: Telegraph Health)

Safety issues and adverse reactions with osteoporosis management.

Wed, 17 Feb 2016 17:43:02 +0100

Authors: Rossini M, Adami G, Adami S, Viapiana O, Gatti D Abstract INTRODUCTION: Osteoporosis is a disease that has spread worldwide and has become a relevant public health problem. Over the last 2 decades, a number of drugs have been licensed for its treatment owing to their efficacy in preventing fragility fractures. The safety profiles of these drugs are well defined with data from extensive programs of pharmacovigilance to support it. Areas covered: In this article we reviewed the long-term safety of Bisphosphonates, Calcium, Vitamin D, Selective Estrogen Receptor Modulators, Teriparatide and Denosumab. We excluded hormone replacement therapy that lost its indication for the treatment of osteoporosis. The license for the treatment of osteoporosis of Calcitonin was recently with...

The current management of Turner Syndrome.

Wed, 17 Feb 2016 07:37:01 +0100

Authors: Kriksciuniene R, Zilaitiene B, Verkauskiene R Abstract Turner Syndrome (TS) is a rare disease, with the incidence of 1 of 2500 life born females. Characteristic features are: growth retardation, gonadal dysgenesis and impairment, congenital and acquired cardiovascular disorders. New management possibilities in Turner Syndrome are coming along with the new scientific evidence on the pathogenesis of TS developmental, metabolic, cardiovascular and reproductive issues. Attitude to the growth retardation treatment and hormone replacement therapy is changing. The effectiveness of additional androgen doses for growth improvement and low estrogen doses in the early childhood for better puberty induction and metabolic outcomes has been demonstrated recently. There are some new conc...

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The Myth of Male Menopause

Wed, 10 Feb 2016 21:10:55 +0100

By John Swartzberg, M.D. It's been dubbed "manopause" or "andropause" -- a midlife change for men that some claim is just like menopause for women. But there's no such thing. "Male menopause" is a creation of the pharmaceutical and supplement industries, along with unscrupulous or uninformed practitioners who feel that some of their potency -- sexual and otherwise -- is declining. It sounds perfectly reasonable at first, but scientifically speaking, there's no evidence that men go through menopause in the same way that women do. That's not to say that men's testosterone levels don't decline with age, just as women's estrogen levels do. But there is no abrupt change, no dramatic drop in testosterone for men at midlife like the hormonal decline that occurs when a woman reaches menopause. I...

Transient Hypothyroidism After Radioiodine for Graves' Disease: Challenges in Interpreting Thyroid Function Tests.

Wed, 10 Feb 2016 00:00:00 +0100

Authors: Sheehan MT, Doi SA Abstract Graves' disease is the most common cause of hyperthyroidism and is often managed with radioactive iodine (RAI) therapy. With current dosing schemes, the vast majority of patients develops permanent post-RAI hypothyroidism and are placed on life-long levothyroxine therapy. This hypothyroidism typically occurs within the first 3 to 6 months after RAI therapy is administered. Indeed, patients are typically told to expect life-long thyroid hormone replacement therapy to be required within this timeframe and many providers expect this post-RAI hypothyroidism to be complete and permanent. There is, however, a small subset of patients in whom a transient post-RAI hypothyroidism develops which, initially, presents exactly as the typical permanent hypoth...

Hypothyroidism complicates bradyarrhythmic episodes in a heart-transplanted patient: Can it be treated with low-dose dopamine?

Tue, 09 Feb 2016 15:07:12 +0100

Authors: Cingoz F Abstract Extracorporeal circulation decreases thyroid hormone levels in peripheral blood. This clinical entity may complicate the postoperative period after heart transplantation if the recipient has taken thyroid hormone replacement therapy. Cardiac transplantation was performed on a patient in whom thyroid hormone levels decreased after surgery. Sinus bradycardia was seen after surgery (30-40 bpm). Thyroid hormones were replaced in the patient. Due to the fact that temporary pacing decreased blood pressure, dopamine was safely given in very low doses. This case was discussed under the literature knowledge. PMID: 26855660 [PubMed - as supplied by publisher] (Source: Polish Journal of Cardio-Thoracic Surgery)

Plasma proprotein convertase subtilisin/kexin type 9 levels and the risk of first cardiovascular events

Sun, 07 Feb 2016 00:00:00 +0100

Conclusions In a large-scale primary prevention cohort, plasma levels of PCSK9 measured at baseline did not predict future cardiovascular events. (Source: European Heart Journal)

Gender difference in gastro-esophageal reflux diseases.

Sun, 07 Feb 2016 00:00:00 +0100

Authors: Asanuma K, Iijima K, Shimosegawa T Abstract The incidence of esophageal adenocarcinoma (EAC) has risen sharply in western countries over the past 4 decades. This type of cancer is considered to follow a transitional process that goes from gastro-esophageal reflux disease (GERD) to Barrett's esophagus (BE, a metaplastic condition of the distal esophagus), a precursor lesion and ultimately adenocarcinoma. This spectrum of GERD is strongly predominant in males due to an unidentified mechanism. Several epidemiologic studies have described that the prevalence of GERD, BE and EAC in women is closely related to reproductive status, which suggests a possible association with the estrogen level. Recently, we revealed in an in vivo study that the inactivation of mast cells by the an...

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Can Hormone Replacement Therapy help hold off dementia?

Sat, 06 Feb 2016 09:33:38 +0100

HRT may protect women against dementia, a new study claims. Women who take oestrogen supplements before the start of menopause had better preserved brain structure. (Source: the Mail online | Health)

Androgen insensitivity syndrome with inguinal testes: MRI diagnosis

Fri, 05 Feb 2016 00:00:00 +0100

We report a case of 20-year-old female who presented with primary amenorrhea to our department. Investigations revealed the absence of female internal genitalia and the presence of testes on MRI in the inguinal canal under the skin. Gonadectomy was done and she was put on female hormone replacement therapy. (Source: The Egyptian Journal of Radiology and Nuclear Medicine)

Association between number of live births and markers of subclinical atherosclerosis: The Dallas Heart Study

Wed, 03 Feb 2016 00:00:00 +0100

Conclusion The number of live births is associated with subclinical coronary and aortic atherosclerosis, with an apparent U-shaped relationship. Further studies are needed to confirm this association and explore the biological underpinnings of these findings. (Source: European Journal of Preventive Cardiology)

Reproductive factors, hormone use and gastric cancer risk: The Singapore Chinese Health Study

Tue, 02 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)

Is Hormone Replacement Therapy Safe in Women With a BRCA Mutation?: A Systematic Review of the Contemporary Literature.

Tue, 02 Feb 2016 00:00:00 +0100

CONCLUSIONS: Decisions regarding the use of HT in women who undergo BSO after detection of a BRCA mutation must be individualized based on careful consideration of the risks and benefits. However, the risks of a subsequent cancer diagnosis appear small, particularly in regards to the benefits of treatment afforded by HT. PMID: 26840041 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)

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Hormone Therapy for Relieving Postmenopausal Vasomotor Symptoms: A Systematic Review.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSION: MHT has a complex pattern. Understanding the natural history of VMS, and the risks and benefits of both hormonal therapies, helps to individualize management plans. Low-dose estrogen-based therapies can be the most effective regimens to relieve VMS. These medications can be used by different administration routes and formulations. PMID: 26838086 [PubMed - in process] (Source: Archives of Iranian Medicine)

Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure

Mon, 01 Feb 2016 00:00:00 +0100

Summary Long-term gonadotropin-releasing hormone agonist (GnRHa) administration before in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in infertile women with endometriosis or adenomyosis significantly enhanced the chances of pregnancy in both fresh and frozen embryo transfer cycles. We hypothesized that long-term GnRHa treatment might also be beneficial for the idiopathic repeated implantation failure (RIF) patients. In the 21 patients receiving GnRHa and hormone replacement therapy (G-HRT) protocols for frozen embryo transfer, their data were compared with those of the 56 of frozen/fresh cycles they had previously undergone (previous protocols). Comparison showed that the finial results were significantly better with G-HRT protocols than with their previous...

Normalization of bone mineral density after five years of treatment with strontium ranelate.

Fri, 29 Jan 2016 00:46:06 +0100

Authors: Sánchez JA Abstract E.F., female, age 58, mother of 4 children and otherwise healthy, had gone into menopause when she was 42. She had received hormone replacement therapy during 8 years. Due to low bone mass she had been treated with oral alendronate during 7 years. She had a normal calcium intake in her diet and engaged in regular physical activity. She did not smoke, and drank alcohol only occasionally. Her mother had sustained a hip fracture at age 90. Bone densitometry of her lumbar spine by DXA showed a T-score of -3.0; standardized bone mineral density (sBMD) had decreased by 11% in the previous 3 years. She was advised to start treatment with strontium ranelate (SrR) 2 g/day, plus oral cholecalciferol (1,000 IU/day). Three months later serum alkaline phosphatase h...

Microbicide Vaginal Rings: Technological Challenges and Clinical Development.

Fri, 29 Jan 2016 00:00:00 +0100

Authors: Malcolm RK, Boyd PJ, McCoy CF, Murphy DJ Abstract Vaginal rings (VRs) are flexible, torus-shaped, polymeric devices designed to sustain delivery of pharmaceutical drugs to the vagina for clinical benefit. Following first report in a 1970 patent application, several steroid-releasing VR products have since been marketed for use in hormone replacement therapy and contraception. Since 2002, there has been growing interest in the use of VR technology for delivery of drugs that can reduce the risk of sexual acquisition of human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). Although no vaginally-administered product has yet been approved for HIV reduction/prevention, extensive research efforts are continuing and a number...

Higher lipid peroxidation in former-smokers vs. never-smokers - study in postmenopausal women.

Thu, 28 Jan 2016 00:58:02 +0100

CONCLUSION: Past smoking is independently associated with the increased damage to membrane lipids regardless of the use of HRT in postmenopausal women. Smoking cessation is not always associated with complete reversion of excessive oxidative damage to all biological macromolecules. PMID: 26812290 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)

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Preclinical studies and clinical evaluation of compounds from the genus Epimedium for osteoporosis and bone health

Thu, 28 Jan 2016 00:00:00 +0100

Publication date: Available online 25 January 2016 Source:Pharmacology & Therapeutics Author(s): Inthrani Raja Indran, Ryan Lim Zhen Liang, Tan Ee Min, Eu-Leong Yong The morbidity and mortality associated with fractures due to osteoporosis or “porous bone” contributes significantly to global healthcare costs and will increase exponentially with ageing populations. In menopausal women, the onset of menopause and rapid estrogen withdrawal leads to osteoporotic fractures. Healthy bone requires the coordinated remodelling function of osteoclasts, osteoblasts, osteocytes in the basic bone multicellular unit; regulated by estrogen, RANKL/OPG, ROS, growth factors and other kinase signalling pathways. Anti-osteoporotic drugs in current use such as hormone replacement therapy, sel...

Feasibility of an Early Discontinuation of Thyroid Hormone Treatment in Very-Low-Birth-Weight Infants at Risk for Transient or Permanent Congenital Hypothyroidism

Wed, 27 Jan 2016 04:36:06 +0100

Conclusion: Early discontinuation of thyroid hormone replacement therapy is possible in the majority of VLBW infants with CH.Horm Res Paediatr 2016;85:131-139 (Source: Hormone Research in Paediatrics)

First‐trimester maternal serum ADAM12‐s and PAPP‐A levels are altered in pregnancies conceived after assisted reproduction techniques (ART)

Tue, 26 Jan 2016 00:00:00 +0100

ConclusionADAM12‐s and PAPP‐A levels are altered in several subgroups of ART pregnancies. Larger studies are required to confirm these findings. © 2015 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)

Migraines May Worsen as Menopause Approaches

Fri, 22 Jan 2016 17:00:00 +0100

Researchers say hormonal changes and painkiller overuse may be to blame Source: HealthDay Related MedlinePlus Pages: Hormone Replacement Therapy, Menopause, Migraine (Source: MedlinePlus Health News)

[Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms].

Fri, 22 Jan 2016 12:14:02 +0100

In conclusion, it can be stated that the supplement evaluated in the present study is able to reduce moderate/severe menopause symptoms. PMID: 26788874 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)

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Buried in Pills

Thu, 21 Jan 2016 21:35:26 +0100

By Drs. David Niesel and Norbert Herzog, Medical Discovery News Have you ever heard doctors referred to as "pill pushers"? While medical professionals provide necessary and admirable services, it does make you wonder how many pills we take in a day, a month, a year or even a lifetime. In the British Museum in London, along with the Rosetta Stone and an Easter Island head, there is an exhibit with an expansive glass table, more than a yard wide and at least 20 yards long. On it rests a tapestry-like depiction of the number of pills two individuals would take over their lifetimes in various colors and sizes. On one side is the medication record of a 76-year-old man and on the other side, a parallel record of an 82-year-old woman. Their life histories as told in pills stretch essentially the...

Oral Estrogen Reverses Ovariectomy-Induced Morning Surge Hypertension in Growth Restricted Mice

Thu, 21 Jan 2016 00:00:00 +0100

In conclusion, GR alters cardiac morphology and cardiovascular regulation. The hemodynamic consequences of GR are attenuated in ovarian-sufficient or estrogen replete females. Further investigations are needed to define the role of hormone replacement therapy targeted towards young women with estrogen deficiency and additional cardiovascular risk factors, including perinatal growth restriction, cardiac hypertrophy and morning surge hypertension. (Source: Clinical Science)

Luteolin suppresses development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats.

Sat, 16 Jan 2016 21:38:04 +0100

Authors: Cook MT, Mafuvadze B, Besch-Williford C, Ellersieck MR, Goyette S, Hyder SM Abstract Postmenopausal women undergoing hormone-replacement therapy containing both progestins and estrogens are at an increased risk of developing breast cancer compared with women taking estrogen alone. We recently demonstrated that medroxyprogesterone acetate, a progestin commonly used for hormone-replacement therapy, accelerates development of mammary carcinogenesis in 7,12-dimethylbenz(a)anthracene‑treated Sprague-Dawley rats. Synthetic antiprogestins used to block the deleterious effects of progestins, are themselves associated with toxic side-effects. In order to circumvent this, we used the aforementioned model to identify less toxic natural compounds that may prevent the development of ...

Hormone replacement therapy after menopause and risk of breast cancer in BRCA1 mutation carriers: a case–control study

Sat, 16 Jan 2016 00:00:00 +0100

Abstract Many BRCA1 mutation carriers undergo elective surgical oophorectomy (often before menopause) to manage their elevated risk of developing ovarian cancer. It is important to clarify whether or not the use of hormone replacement therapy (HRT) to mitigate the symptoms associated with surgical or natural menopause is safe in women with an inherited BRCA1 mutation and no personal history of breast or ovarian cancer. We conducted a case–control analysis of 432 matched pairs of women with a BRCA1 mutation. Detailed information on HRT use after menopause (duration, type, age at first/last use, formulation) was obtained from a research questionnaire administered at the time of study enrollment. Conditional logistic regression was used to estimate the odds ratio (OR) and 95 % con...

'Man Flu' Stories Show How We Make Women's Health All About Dudes

Fri, 15 Jan 2016 18:47:17 +0100

Whiny men might be excited by recent news stories that claim “man flu” -- the trope that men turn into bedridden drama kings at the slightest hint of a sniffle -- is real and totally justified because men have a harder time fighting off the flu. These headlines are based on a recent study that suggests estrogen could play a role in flu resistance. But the lead researcher said it's a huge "leap in logic" to say this proves anything about "man flu," and she emphasized that her study really doesn’t have much to do with guys, whiny or otherwise. “I find it so interesting that [my research] got misrepresented to be all about men,” said Sabra Klein, associate professor of molecular microbiology and immunology at Johns Hopkins Bloomberg Schoo...

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Parity and 11-year serum thyrotropin and thyroid autoantibody change: A longitudinal population-based study.

Tue, 12 Jan 2016 03:10:02 +0100

Conclusions We found no statistically significant association between the studied female reproductive measures and 11-year risk of TSH or TPO-change. A possible protective role for hormone replacement therapy in the etiology of thyroid autoimmunity however deserves further research. PMID: 26711373 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)

Proportion of premenopausal and postmenopausal breast cancers attributable to known risk factors: Estimates from the E3N‐EPIC cohort

Tue, 12 Jan 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)

Estrogenic Activity Including Bone Enhancement and Effect on Lipid Profile of Luteolin‐7‐O‐glucoside Isolated from Trifolium alexandrinum L. in Ovariectomized Rats

Mon, 11 Jan 2016 00:00:00 +0100

Luteolin‐7‐O‐glycoside (LG), an abundant component in many edible plants, was found to be one of the major constituents of the aqueous methanol extract of Trifolium alexandrinum L. family Fabaceae, a fodder plant widely cultivated in Egypt. The estrogenic activity of LG concerning the effect on uterotrophy, lipid profile, weight gain and bone enhancement activity was determined in ovariectomized rat model at a dose of 5 mg/kg. Luteolin‐7‐O‐glycoside showed significant estrogenic effect through the preservation of normal uterine weight and plasma estradiol level. It also significantly inhibited the bone turnover markers plasma bone‐specific alkaline phosphatase, plasma osteocalsin, type I procollagen N‐terminal, and C‐telopeptide of type II collagen levels. It induced a ...

Suppression of experimental arthritis and associated bone loss by a tissue-selective estrogen complex.

Fri, 08 Jan 2016 00:00:00 +0100

In conclusion, a TSEC, herein combined BZA/E2, suppresses experimental arthritis and prevents associated bone loss as efficient as E2 alone but with minimal uterine effects, highlighting the need for clinical trials that evaluate the addition of a TSEC to conventional postmenopausal RA treatment. PMID: 26745543 [PubMed - as supplied by publisher] (Source: Endocrinology)

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Abstract B172: RP10107, a novel and potent glutaminase inhibitor, potentiates taxol activity in breast cancer cell lines

Thu, 07 Jan 2016 00:00:00 +0100

Conclusions: Addition of RP10107, a potent and selective GLS-1 inhibitor, potentiated Taxol activity in breast cancer cells with remarkable synergy evident in the TNBC cell line, MDA-MB-231. Findings provide a rationale for use of the combination in future clinical trials involving hard-to-treat TNBC patients thereby providing a safer and much effective option compared to currently available therapy.Citation Format: Kumar V. Penmetsa, Satyanarayana Eleswarapu, Saketh Sriram Dinavahi, Srikant Viswanadha, Swaroop Vakkalanka. RP10107, a novel and potent glutaminase inhibitor, potentiates taxol activity in breast cancer cell lines. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): ...

Early Menopause Linked to Later DepressionEarly Menopause Linked to Later Depression

Wed, 06 Jan 2016 19:38:15 +0100

A new meta-analysis suggests longer-term exposure to endogenous estrogens may have antidepressive benefits; however, the role of hormone replacement therapy is unclear. Medscape Medical News (Source: Medscape Psychiatry Headlines)

Pre-diagnostic high-sensitive C-reactive protein and breast cancer risk, recurrence, and survival

Wed, 06 Jan 2016 00:00:00 +0100

Abstract Inflammation may initiate and promote breast cancer development, and be associated with elevated circulating levels of inflammation markers. A total of eight 130 initially healthy women, participated in the population-based Tromsø study (1994–2008). Pre-diagnostic high-sensitivity C-reactive protein (hs-CRP) was assessed. During 14.6 years of follow-up, a total of 192 women developed invasive breast cancer. These cases were followed for additional 7.2 years. Detailed medical records were obtained. We observed an overall positive dose–response relationship between pre-diagnostic hs-CRP and breast cancer risk (hazard ratio (HR) = 1.06, 95 % CI 1.01–1.11). Postmenopausal women with above median levels of hs-CRP (>1.2 mg/l) had a 1.42 (95 % CI 1.01–2.00...

Resting Energy Expenditure is Decreased in Pseudohypoparathyroidism Type 1A.

Mon, 28 Dec 2015 00:00:00 +0100

CONCLUSION: Our results are consistent with reduced energy expenditure being the principle cause of obesity in PHP1A rather than it being caused by excessive energy intake or endocrine dysfunction. PMID: 26709970 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Treating vulvovaginal atrophy/genitourinary syndrome of menopause: how important is vaginal lubricant and moisturizer composition?

Sat, 26 Dec 2015 00:00:00 +0100

Authors: Edwards D, Panay N Abstract Vaginal dryness is a common condition that is particularly prevalent during and after the menopause, and is one of the symptoms of vulvovaginal atrophy/genitourinary syndrome of menopause. The impact of vaginal dryness on interpersonal relationships, quality of life, daily activities, and sexual function can be significant, but is frequently underestimated. Furthermore, barriers exist to treatment-seeking, and this condition is often underreported and undertreated. Greater education about vaginal dryness and the range of available treatments is essential to encourage more women to seek help for this condition. Personal lubricants and moisturizers are effective at relieving discomfort and pain during sexual intercourse for women with mild to mode...

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Natural menopause the easy way

Thu, 24 Dec 2015 11:20:14 +0100

The post Natural menopause the easy way appeared first on Hysterectomy Association. For many women, going through the menopause means experiencing menopausal symptoms. These will be mild for some women, but for others, severe symptoms can affect them both physically and psychologically. Issues can include vaginal dryness, headaches, night sweats, mood changes, loss of libido, fatigue, and depression, so knowing how to manage these symptoms effectively can help a woman cope with the menopause. Although hormone replacement therapy (HRT) is the first line of treatment usually prescribed, the infographic below shows there are many ways to have a more natural menopause focused on tips and lifestyle changes that can help to ease menopausal symptoms for a happy, and healthy life. The post Natura...

Hormone replacement therapy after treatment for a gynaecological malignancy

Wed, 23 Dec 2015 21:00:15 +0100

Purpose of review: Provision of hormone replacement therapy (HRT) to women following a diagnosis of a gynaecological malignancy is a complex and controversial area associated with a lack of published guidance. As the average age of women affected by gynaecological cancer decreases and survival following provision of effective therapies increases, clinicians face new considerations for longer-term health concerns of patients. Additionally, there is a growing understanding of the influence of tumour biology upon response to cytotoxic therapies and it is essential that we use this knowledge to guide provision of HRT. Recent findings: Available evidence for ovarian, vulval, cervical, and endometrial cancers demonstrates no excess risk of recurrence in patients taking HRT with the exception of ...

Clinical management of teratoma, a rare hypothalamic-pituitary neoplasia

Wed, 23 Dec 2015 00:00:00 +0100

Abstract Intracranial teratomas are rare and comprise about 0.5 % of all intracranial tumours. Actually, a total of 15 cases of sellar-suprasellar teratoma have been described in the last 24 years. Although rare, hypothalamic-pituitary teratomas should be taken into account in the differential diagnosis of hypothalamic-pituitary region tumours. The current review focuses on the clinical and therapeutic management of pituitary region teratomas. Teratomas occur more frequently in children and young adults than in the older population and in males as compared to females. Symptoms at diagnosis are usually neurological defects, diabetes insipidus and hypopituitarism. Teratoma diagnosis can be suggested though neuroimaging findings. Magnetic resonance imaging remains the preferred...

First trimester maternal serum ADAM12‐s and PAPP‐A levels are altered in pregnancies conceived after assisted reproduction techniques (ART)

Wed, 23 Dec 2015 00:00:00 +0100

ConclusionADAM12‐s and PAPP‐A levels are altered in several subgroups of ART pregnancies. Larger studies are required to confirm these findings. This article is protected by copyright. All rights reserved. (Source: Prenatal Diagnosis)

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Postepy Hig Med Dosw 2015; 69:285-293 " Long-term use of estrogens: benefit or risk"

Tue, 22 Dec 2015 00:23:54 +0100

Estrogens are widely used in hormone replacement therapy, gynecology, urogynecology and rarely in dermatology. Non-therapeutic use of estrogens is very widespread. Estrogens are used as contraceptives, which cause a lot of serious side effects. A common clinical problem is skin hyperpigmentation (melasma), occurring mainly in women who take contraceptives with high doses of estrogens. But low doses of estrogens may also cause skin side effects. The mechanism of melasma development is very complicated and not fully understood. It is very likely that UV radiation and genetic background can affect melasma development. Effective therapy should lead to prevention or alleviation of relapses. Treatment should also reduce the area of lesions and improve the appearance of skin. There is no effectiv...

High-Dose Estradiol-Replacement Therapy Enhances the Renal Vascular Response to Angiotensin II via an AT2-Receptor Dependent Mechanism.

Mon, 21 Dec 2015 22:38:02 +0100

Authors: Safari T, Nematbakhsh M, Evans RG, Denton KM Abstract Physiological levels of estrogen appear to enhance angiotensin type 2 receptor- (AT2R-) mediated vasodilatation. However, the effects of supraphysiological levels of estrogen, analogous to those achieved with high-dose estrogen replacement therapy in postmenopausal women, remain unknown. Therefore, we pretreated ovariectomized rats with a relatively high dose of estrogen (0.5 mg/kg/week) for two weeks. Subsequently, renal hemodynamic responses to intravenous angiotensin II (Ang II, 30-300 ng/kg/min) were tested under anesthesia, while renal perfusion pressure was held constant. The role of AT2R was examined by pretreating groups of rats with PD123319 or its vehicle. Renal blood flow (RBF) decreased in a dose-related...

Sarcopenia in chronic kidney disease.

Mon, 21 Dec 2015 03:45:46 +0100

Authors: Souza VA, Oliveira Dd, Mansur HN, Fernandes NM, Bastos MG Abstract Sarcopenia is a chronic condition associated with physiological aging process and is defined by the reduction of the mass, muscle strength and function. In Chronic Kidney Disease (CKD), sarcopenia is prevalent and is associated with increased morbidity and mortality and the occurrence of cardiovascular complications. By analyzing sarcopenia in patients with renal insufficiency, complex mechanisms that contribute to loss of muscle mass are highlighted, such as activation of mediators that stimulate the ubiquitin-proteasome system (SUP) ATP-dependent, inflammation, metabolic acidosis, angiotensin II and some hormonal factors. The therapeutic approach to sarcopenia in CKD includes exercises, correction of meta...

Sex Steroid Replacement Therapy in Female Hypogonadism from Childhood to Young Adulthood.

Mon, 21 Dec 2015 00:58:17 +0100

Authors: Norjavaara E, Ankarberg-Lindgren C, Kriström B Abstract The overall goal of pubertal sex hormone replacement therapy (HRT) in girls is not only about development of secondary sexual characteristics, but also to establish an adult endocrine and metabolic milieu, as well as adult cognitive function. Estradiol (E2) is the first choice for HRT compared to ethinyl estradiol (EE2). E2 is the most potent endogenous estrogen in the circulation, with established levels during spontaneous puberty. Transdermal E2, compared to oral administration, is the first choice to start pubertal HRT. Transdermal application avoids liver exposure to supraphysiologic estrogen concentrations and provides a more physiologic mechanism for hormone delivery. By cutting E2 matrix patches in doses of 0....

Effects of low dose of tibolone on steroid receptors and Bcl-2 on the postmenopausal endometrium.

Sun, 20 Dec 2015 07:42:02 +0100

CONCLUSION: Tibolone in a daily dose of 1.25 mg during 24 weeks demonstrated endometrial action that resulted in low proliferation and was shown to lead to atrophic endometrium. It had favorable effects on the postmenopausal endometrium due to its higher immunoexpression of PR and Bcl-2 protein in endometrial glandular epithelium, thereby creating a balance between pro-apoptotic and anti-apoptotic actions. PMID: 26670665 [PubMed - as supplied by publisher] (Source: Histology and Histopathology)

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Differences in the lipid profile and hormone replacement therapy use in Korean postmenopausal women: the Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2012

Sat, 19 Dec 2015 00:00:00 +0100

Conclusion The results of this study suggest that the use of HRT may have a positive effect on dyslipidemia in postmenopausal women. (Source: Archives of Gynecology and Obstetrics)

Transvaginal ultrasound examination of the endometrium in postmenopausal women without vaginal bleeding.

Fri, 18 Dec 2015 00:00:00 +0100

CONCLUSION: About 10% of gynecologically asymptomatic postmenopausal women have sonographic endometrial thickness ≥ 5mm. Our results support conservative management of such women. PMID: 26678251 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time.

Thu, 17 Dec 2015 04:30:03 +0100

In this study, a literature search of PubMed, Embase, and Cochrane databases up to May 2015 was performed, with the search restricted to English language publications. The studies were screened after reading the abstract and full text. Only studies related to the effect of HRT on DES were included in the meta-analysis. Results of Schirmer tests with and without anesthetics and tear break-up time (BUT) values data were extracted and entered into RevMan software to meta-analyze the overall effect of HRT on DES. A total of 43 studies were identified, and 21 of these studies were found to be related to the effect of HRT on DES. Ultimately, 5 studies were included in the final meta-analysis. The pooled results revealed that HRT can affect Schirmer test results without anesthetics but does not a...

Being happy 'won't help you live longer' survey finds

Fri, 11 Dec 2015 12:10:00 +0100

ConclusionThis large prospective study aimed to assess whether happiness or related measures of wellbeing are associated with risk of death, after allowing for the influence of the poor health and lifestyles of people who are unhappy.The study found poor health was linked with unhappiness in middle-aged women. However, after allowing for this association and adjusting for the influence of other factors that may be associated, such as smoking and poor socioeconomic status, happiness and related measures of wellbeing do not appear to have any direct effect on death. This suggests that, as has sometimes previously been speculated, (un)happiness does not have a direct influence on mortality, but is being influenced by other associated factors.  However, this study has both strengths and limi...

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To Treat or Not to Treat: The Use of Hormone Replacement Therapy in Patients With Ovarian Cancer [EDITORIALS]

Tue, 08 Dec 2015 00:00:00 +0100

(Source: Journal of Clinical Oncology)

Adjuvant Hormone Therapy May Improve Survival in Epithelial Ovarian Cancer: Results of the AHT Randomized Trial [Gynecologic Cancer]

Tue, 08 Dec 2015 00:00:00 +0100

Conclusion These results show that women who have severe menopausal symptoms after ovarian cancer treatment can safely take hormone-replacement therapy, and this may, in fact, infer benefits in terms of OS in addition to known advantages in terms of quality of life. (Source: Journal of Clinical Oncology)

Evaluation of the prevalence, type, severity, and risk factors of urinary incontinence and its impact on quality of life among women in Turkey

Sat, 05 Dec 2015 00:00:00 +0100

Conclusion In this study, the prevalence of UI in women was substantial, and UI had a significantly negative impact on all aspects of QoL. However, these women had not sought medical help for the problem. Therefore, health professionals should query women of all ages about symptoms of this prevalent condition and offer treatment if it is detected. (Source: International Urogynecology Journal)

Case of pituitary stalk transection syndrome ascertained after breech delivery

Thu, 03 Dec 2015 00:00:00 +0100

We present a case of PSTS ascertained after breech delivery. A 20‐year‐old woman presented with primary amenorrhea. The patient was born by breech delivery and had a history of treatment for pituitary dwarfism. Her laboratory findings showed pituitary hypothyroidism, and hormone replacement therapy was initiated. At 28 years old, she became pregnant and had a normal delivery at 38 weeks' gestation. One year after delivery, her thyroid hormone level changed. Laboratory test showed adrenocortical insufficiency, and magnetic resonance imaging of the pituitary gland showed transection of the pituitary stalk and development of an ectopic posterior lobe. These findings were compatible with PSTS. When a patient who has been born by breech delivery presents with symptoms of pituitary deficienc...

Synthesis and chemical reactions of the steroidal hormone 17α-methyltestosterone

Wed, 02 Dec 2015 00:00:00 +0100

Publication date: Available online 2 December 2015 Source:Steroids Author(s): El-Sayed Ibrahim El-Desoky, Mahmoud Reyad, Elsayed Mohammed Afsah, Abdel-Aziz Mahmoud Dawidar Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen–androgen hormone replacement therapy treatment. The analog also offers special possibilities for the prevention/treatment of hormone-sensitive cancers. The testosterone skeleton has important functionalities in the molecule that can act as a carbonyl component, an active methylene compound, α,β-u...

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Transvaginal ultrasound examination of the endometrium in postmenopausal women without vaginal bleeding

Tue, 01 Dec 2015 00:00:00 +0100

ConclusionAbout 10% of gynecologically asymptomatic postmenopausal women have sonographic endometrial thickness ≥ 5mm. Our results support conservative management of such women. (Source: Ultrasound in Obstetrics and Gynecology)

Correlation between mammography detected breast arterial calcifications and lifestyle risk factors.

Mon, 30 Nov 2015 21:58:02 +0100

CORRELATION BETWEEN MAMMOGRAPHY DETECTED BREAST ARTERIAL CALCIFICATIONS AND LIFESTYLE RISK FACTORS. Acta Clin Croat. 2015 Jun;54(2):143-8 Authors: Kosović V, Krolo I, Zadravec D, Drviš P Abstract The aim of the study was to investigate the association between some lifestyle-attributable risk factors of atherosclerosis, such as body mass index (BMI), oral contraceptives, hormone replacement therapy, smoking and alcohol consumption with breast arterial calcification (BAC) and its intensity on mammograms, and to assess the impact of these lifestyle risk factors on mammography findings of BAC. This prospective study included 300 women aged 47-69, i.e. a group of 149 women with BAC on mammograms and control group of 151 women without BAC. Self-reported BMI, use of oral co...

Asymmetric facial skin viscoelasticity during climacteric aging.

Mon, 30 Nov 2015 21:48:04 +0100

CONCLUSION: Facial skin viscoelasticity appeared to be asymmetric following menopause. The possibility of asymmetry should be taken into account in future studies of the effects of hormone replacement therapy and any antiaging procedure on the face in menopausal women. PMID: 24748810 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)

Transcutaneous posterior tibial nerve stimulation versus extended release oxybutynin in overactive bladder patients. A prospective randomized trial

Sun, 29 Nov 2015 00:00:00 +0100

Conclusion T.C. PTNS and E.R.O. demonstrated similar improvements in subjects with OAB in a 12-week study. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)

Licorice Root Components in Dietary Supplements are Selective Estrogen Receptor Modulators with a Spectrum of Estrogenic and Anti-Estrogenic Activities

Fri, 27 Nov 2015 00:00:00 +0100

Publication date: Available online 26 November 2015 Source:Steroids Author(s): Nittaya Boonmuen, Ping Gong, Zulfiqar Ali, Amar G. Chittiboyina, Ikhlas Khan, Daniel R. Doerge, William G. Helferich, Kathryn E. Carlson, Teresa Martin, Pawinee Piyachaturawat, John A. Katzenellenbogen, Benita S. Katzenellenbogen Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extracts also contain a number of other flavonoids, isoflavonoids, and chalcones. We have investigated the estrogenic activity of 7 of these components, obtained from an extra...

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Ethanolic extract of dandelion (Taraxacum mongolicum) induces estrogenic activity in MCF-7 cells and immature rats

Wed, 25 Nov 2015 00:00:00 +0100

Publication date: November 2015 Source:Chinese Journal of Natural Medicines, Volume 13, Issue 11 Author(s): Seung Min Oh, Ha Ryong Kim, Yong Joo Park, Yong Hwa Lee, Kyu Hyuck Chung Plants of the genus Taraxacum, commonly known as dandelions, are used to treat breast cancer in traditional folk medicine. However, their use has mainly been based on empirical findings without sufficient scientific evidence. Therefore, we hypothesized that dandelions would behave as a Selective estrogen receptor modulator (SERM) and be effective as hormone replacement therapy (HRT) in the postmenopausal women. In the present study, in vitro assay systems, including cell proliferation assay, reporter gene assay, and RT-PCR to evaluate the mRNA expression of estrogen-related genes (pS2 and progesterone rec...

Exposure to polybrominated diphenyls ether (PBDE) and Hypothyroidism in Canadian women.

Wed, 25 Nov 2015 00:00:00 +0100

CONCLUSION: plasma PBDE levels were associated with increased prevalence of hypothyroidism in Canadian women ages 30-50 years. Although the cross-sectional design of the study precludes inferences of causality, these findings have important implications given the key role of thyroid hormones in several biological mechanisms during reproductive age. PMID: 26606679 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Exercise training is an effective alternative to estrogen supplementation for improving glucose homeostasis in ovariectomized rats

Tue, 24 Nov 2015 00:00:00 +0100

Abstract The irreversible loss of estrogen (specifically 17‐β‐estradiol; E2) compromises whole‐body glucose tolerance in women. Hormone replacement therapy (HRT) is frequently prescribed to treat estrogen deficiency, but has several deleterious side effects. Exercise has been proposed as an HRT substitute, however, their relative abilities to treat glucose intolerance are unknown. Thirty ovariectomized (OVX) and 20 SHAM (control) rats underwent glucose tolerance tests (GTT) 10 weeks post surgery. Area under the curve (AUC) for OVX rats was 60% greater than SHAM controls (P = 0.0005). Rats were then randomly assigned to the following treatment groups: SHAM sedentary (sed) or exercise (ex; 60 min, 5×/weeks), OVX sed, ex, or E2 (28 μg/kg bw/day) for 4 weeks. OVX ex rats experie...

Predictors of reoperation after sacral neuromodulation: A single institution evaluation of over 400 patients

Fri, 20 Nov 2015 00:00:00 +0100

ConclusionsIn this largest known series to date, one third of the patients required reoperation and the most common reason was lack of efficacy/worsening symptoms. Ongoing study is needed as the technology continues to evolve. Neurourol. Urodynam. © 2015 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)

Parity and the risk of cataract: a cross-sectional analysis in the Dongfeng-Tongji cohort study

Fri, 20 Nov 2015 00:00:00 +0100

Conclusions The findings suggested that parity was an independent risk factor for the development of cataract in Chinese women. (Source: British Journal of Ophthalmology)

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