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MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Drugs & Pharmacology



Last Build Date: Mon, 28 Mar 2016 15:37:15 +0100

 



Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF‐C/VEGFR‐3 signaling pathway

Mon, 28 Mar 2016 13:34:32 +0100

CONCLUSIONS AND IMPLICATIONSBased on these findings, we propose toluquinol as a new candidate with pharmacological potential for the treatment of lymphangiogenesis‐related pathologies. Notably, its ability to suppress corneal neovascularization paves the way for applications in vascular ocular pathologies. This article is protected by copyright. All rights reserved. (Source: British Journal of Pharmacology)

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Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison

Sun, 27 Mar 2016 22:00:00 +0100

The objective of the current study was to further elucidate the metabolic pathways of lenvatinib in humans and to compare these results to the metabolism in rats and monkeys. To this end, we used plasma, urine and feces collected in a human mass balance study after a single 24 mg (100 μCi) oral dose of 14C-lenvatinib. Metabolites of 14C-lenvatinib were identified using liquid chromatography (high resolution) mass spectrometry with off-line radioactivity detection. Close to 50 lenvatinib-related compounds were detected. In humans, unchanged lenvatinib accounted for 97 % of the radioactivity in plasma, and comprised 0.38 and 2.5 % of the administered dose excreted in urine and feces, respectively. The primary biotransformation pathways of lenvatinib were hydrolysis, oxidation and hydrox...



CA-1H, a novel oxazole bearing analogue of combretastatin A-4, disrupts the tumor vasculatures and inhibits the tumor growth via inhibiting tubulin polymerization

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Fuguo Han, Peng Wang, Wei Zhang, Jing Li, Qun Zhang, Xin Qi, Ming Liu Vascular disrupting agents destroy established tumor vasculatures selectively, and have achieved encouraging antitumor activity in both pre-clinical and clinical trials. In the present study, we reported the vascular disruption and antitumor effects of CA-1H and its prodrug CA-1HP, oxazole bearing analogues of combretastatin A-4 (CA4). CA-1H was a tighter binder of tubulin than CA4 with the same binding site to chochcine and CA4, and inhibited tubulin polymerization both in cell free system and in human umbilical vein endothelial cells (HUVECs). Furthermore, CA-1H significantly disrupted the microtubulin skeleton in pro...



Improved tumor targeting and antitumor activity of camptothecin loaded solid lipid nanoparticles by preinjection of blank solid lipid nanoparticles

Sat, 26 Mar 2016 23:00:00 +0100

This study aimed to enhance the in vivo antitumor effects of camptothecin (CPT), a strong antitumor agent whose delivery is limited by poor aqueous solubility and instability of the active lactone form. CPT was loaded into sterically stabilized, solid lipid nanoparticles (CPT-SLNs) formulated for intravenous administration. The influence of preinjected blank SLNs on the tumor targeting, pharmacokinetics and antitumor activity of CPT-SLNs was investigated. The CPT-SLNs composed of trilaurin-based lipid matrix containing poloxamer188 and pegylated phospholipid as stabilizers were prepared by hot homogenization method and evaluated for in vitro characteristics and in vivo performance. The CPT-SLNs showed an in vitro long-term sustained release pattern and effectively protected the CPT lactone...



Formation and characterization of β-cyclodextrin (β-CD) – polyethyleneglycol (PEG) – polyethyleneimine (PEI) coated Fe3O4 nanoparticles for loading and releasing 5-Fluorouracil drug

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): G. Prabha, V. Raj In this work, β-cyclodextrin (β-CD) – polyethyleneglycol (PEG) – polyethyleneimine (PEI) coated iron oxide nanoparticles (Fe3O4-β-CD-PEG-PEI) were developed as drug carriers for drug delivery applications. The 5- Fluorouracil (5-FU) was chosen as model drug molecule. The developed nanoparticles (Fe3O4-β-CD-PEG-PEI) were characterized by various techniques such as Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). The average particles size range of 5-FU loaded Fe3O4-β-CD, Fe3O4-β-CD-PEG and Fe3O4-β-CD-PEG-PEI nanoparticles were f...

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15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy

Sat, 26 Mar 2016 23:00:00 +0100

Conclusion 15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating the anti-oxidative stress factor HO-1 and reducing the production of cytokines and ROS, thereby inhibiting hepatic cell autophagy probably induced by ROS. (Source: Biomedicine and Pharmacotherapy)



Caspase dependent apoptotic inhibition of melanoma and lung cancer cells by tropical Rubus extracts

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Blassan Plackal Adimuriyil George, Heidi Abrahamse, Nanjundaswamy M. Hemmaragala Rubus fairholmianus Gard. inhibits human melanoma (A375) and lung cancer (A549) cell growth by the caspase dependent apoptotic pathway. Herbal products have a long history of clinical use and acceptance. They are freely available natural compounds that can be safely used to prevent various ailments. The plants and plant derived products became the basis of traditional medicine system throughout the world for thousands of years. The effects of R. fairholmianus root acetone extract (RFRA) on the proliferation of A375 and A549 cells was examined in this study. RFRA led to a decrease in cell viability, proliferation ...



Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): K.-H. Lam, K.K.-H. Lee, S.H.-L. Kok, R.S.-M. Wong, F.-Y. Lau, G.Y.-M. Cheng, W.-Y. Wong, S.-W. Tong, K.-W. Chan, R.Y.-K. Chan, J.C.-O. Tang, C.-H. Cheng, D.K.-P. Hau, Z.-X. Bian, R. Gambari, C.-H. Chui Tumour growth is closely related to the development of new blood vessels to supply oxygen and nutrients to cancer cells. Without the neovascular formation, tumour volumes cannot increase and undergo metastasis. Antiangiogenesis is one of the most promising approaches for antitumour therapy. The exploration of new antiangiogenic agents would be helpful in antitumour therapy. Quinoline is an aromatic nitrogen compound characterized by a double-ring structure which exhibits a benzene ...



Off-Target Drug Effects Resulting in Altered Gene Expression Events with Epigenetic and “Quasi-Epigenetic” Origins

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Pharmacological Research Author(s): Stephen J. Anderson, Kristina M. Feye, Garrett R. Schmidt-McCormack, Emir Malovic, Gregory S.A. Mlynarczyk, Patricia Izbicki, Larissa F. Arnold, Matthew A. Jefferson, Bierlein M. de la Rosa, Rita F. Wehrman, KC Luna, Hilary Z. Hu, Naveen C. Kondru, Michael D. Kleinhenz, Joe S. Smith, Sireesha Manne, Marson R. Putra, Shivani Choudhary, Nyzil Massey, Diou Luo, Carrie A. Berg, Sreemoyee Acharya, Shaunik Sharma, Sri Harsha Kanuri, Jennifer K. Lange, Steve A. Carlson This review synthesizes examples of pharmacological agents that have off-target effects of an epigenetic nature. We expand upon the paradigm of epigenetics to include “quasi-epigenetic” mechanisms. Quasi-epige...



CurcuminDownregulates Human Tumor Necrosis Factor-α Levels:A systematic review and meta-analysis ofrandomized controlled trials

Sat, 26 Mar 2016 23:00:00 +0100

CONCLUSION This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating TNF-α concentration. Graphical abstract (Source: Pharmacological Research)

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Deoxynivalenol inhibits proliferation and induces apoptosis in human umbilical vein endothelial cells

Sat, 26 Mar 2016 23:00:00 +0100

In this study, we investigated the toxic and apoptotic effects of DON in human umbilical vein endothelial cells (HUVECs), a good model for studying inflammation. The results show that DON significantly inhibited the viability of HUVECs. DON could also inhibit the proliferation of HUVECs through G2/M phase arrest in cell cycle progression. Moreover, oxidative stress induced by DON was indicated by observations of increased levels of reactive oxygen species (ROS). In addition, DON also causes mitochondrial damage by decreasing the mitochondrial membrane potential and inducing apoptosis by up-regulation of apoptosis-related genes like caspase-3, caspase-9, and Bax genes, and down-regulation of Bcl-2 gene. These results together suggest that DON could induce cell cycle arrest, oxidative stress...



Nonylphenol-induced Hyperadrenalism Can Be Reversed/Alleviated by Inhibiting of 11-β Hydroxysteroid Dehydrogenase Type 1

Sat, 26 Mar 2016 23:00:00 +0100

This study examined the effect of PF915275 (a selective 11β-HSD1 inhibitor) on hyperadrenalism and adipogenesis in male rats exposed to NP during development. The results showed that treatment with the 11β-HSD1 inhibitor PF915275 reversed/alleviated NP-induced hyperadrenalism via the following mechanisms: (1) decreasing serum corticosterone, 11β-hydroxylase, and aldosterone synthase levels; (2) significantly increasing PPARα protein and mRNA expression. In adipose tissue, NP significantly increased PPARγ mRNA expression, whereas PF915275 significantly decreased the level of mRNA expression; and (3) the expression of key regulators/enzymes in the adipogenesis metabolic pathway was also modulated. (Source: Environmental Toxicology and Pharmacology)



Prevalence and incidence of liver enzyme elevations in a pooled oncology clinical trial cohort

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Regulatory Toxicology and Pharmacology Author(s): Sumitra Shantakumar, Sarah Landis, Andy Lawton, Christine M. Hunt Few epidemiologic studies describe longitudinal liver chemistry (LC) elevations in cancer patients. A population-based retrospective cohort was identified from 31 Phase 2-3 oncology trials (excluding targeted therapies) conducted from 1985-2005 to evaluate background rates of LC elevations in patients (n=3998) with or without liver metastases. Patients with baseline liver metastases (29% of patients) presented with a 3% prevalence of alanine transaminase (ALT) ≥3x upper limits normal (ULN) and 0.2% prevalence of bilirubin ≥3xULN. During follow-up, the incidence (per 1000 person-months) of new onset ALT elevatio...



Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionsAZI–PQ appears to be well tolerated and safe in pregnancy. Based on the present/other data, total AZI doses higher than 3 g for the treatment and prevention of malaria may be unnecessary in pregnant women, while clearance of parasitaemia could improve the relative bioavailability of PQ. (Source: British Journal of Clinical Pharmacology)



How to take into account exposure to drugs over time in pharmacoepidemiology studies of pregnant women?

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionsThe proposed new method enabled us to describe more precisely women's exposure to drugs during pregnancy, and to distinguish different profiles of exposure. This method could be used to investigate specific outcomes related to duration and intensity of drug exposure during pregnancy, and also to study adverse drug reactions throughout life. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)



Stability-indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC–TOF/MS, LC–MS/MS and NMR

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: 5 June 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 125 Author(s): Yidi Yang, Xi Zhu, Fei Zhang, Wei Li, Ying Wu, Li Ding Stress testing was carried out under acidic, alkaline, oxidative, thermal and photolytic conditions to evaluate the intrinsic stability of posaconazole injection. A total of four degradation products were detected and the drug was found to be susceptible to oxidative and thermal degradations. Three unknown degradants formed under oxidative stress condition were isolated by preparative HPLC and unambiguously elucidated by LC–TOF/MS, LC–MS/MS, 1H NMR, 13C NMR and 2D NMR techniques. Based on the spectrometric and spectroscopic information, these novel degradation products were unequivocally assigned as the N-oxides of ...



Microwave-assisted ionic liquid homogeneous liquid–liquid microextraction coupled with high performance liquid chromatography for the determination of anthraquinones in Rheum palmatum L.

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: 5 June 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 125 Author(s): Zhibing Wang, Jianxue Hu, Hongxia Du, Shuang He, Qing Li, Hanqi Zhang The microwave-assisted ionic liquid homogeneous liquid–liquid microextraction (MA-IL-HLLME) coupled with high performance liquid chromatography with diode array detection (HPLC-DAD) was developed for the determination of anthraquinones, including aloe-emodin, emodin, chrysophanol and physcion in root of Rheum palmatum L. Several experimental parameters influencing the extraction efficiency, including amount of sample, type and volume of ionic liquid, volume and pH value of extraction medium, microwave power and extraction time, concentration of NH4PF6 as well as centrifugal condition were optimized. Whe...



Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations.

Sat, 26 Mar 2016 19:03:01 +0100

Authors: Barbosa JS, Almeida Paz FA, Braga SS Abstract Montelukast sodium is a leukotriene antagonist of growing interest as an alternative therapy for asthma across different age groups due to its bronchoprotective, anti-inflammatory and anti-allergic properties. Currently, montelukast is commercialized only in oral solid dosage forms, which are the favourite of adult patients but may pose challenges in administration to children of young age or patients suffering from dysphagia. This review presents a comprehensive revision of scientific reports and patents on emerging strategies for the delivery of montelukast. A common ground to these reports is the pursue of an enhanced montelukast performance, by increasing its bioavailability and physico-chemical stability. A wide variety of...

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Comparative plasma and milk dispositions, faecal excretion and efficacy of per os ivermectin and pour‐on eprinomectin in horses

Sat, 26 Mar 2016 17:07:37 +0100

In conclusion, due to the relatively low excretion in milk, EPM and IVM may be used safely in lactating mares if their milk is used for human consumption. Nevertheless, much lower plasma and faecal availabilities of EPM could result in subtherapeutic concentrations, which may increase the risk of drug resistance in nematodes after pour‐on EPM administration compared with per os IVM. (Source: Journal of Veterinary Pharmacology and Therapeutics)



Comparison of impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate and phenobarbital.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Compared with PB, TPM showed a better effect on epilepsy treatment with less adverse reactions which were worthy of clinical recommendation. PMID: 27010160 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Urate lowering therapies in the treatment of gout: a systematic review and meta-analysis.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: On the basis of the reported data, febuxostat can play a major role in the treatment of hyperuricaemia and gout. Febuxostat is a suitable pharmacological option for first line treatment of gout, given its established efficacy and safety, documented in a high number of clinical studies and in daily practice. PMID: 27010159 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



A study on the role of apoptotic human umbilical cord mesenchymal stem cells in bleomycin-induced acute lung injury in rat models.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Human umbilical cord mesenchymal stem cell transplantation may have a bright future in the clinical setting for the treatment of ALI/acute respiratory distress syndrome (ARDS). Apoptotic human umbilical cord mesenchymal stem cells may have more effective than normal human umbilical cord mesenchymal stem cells in the treatment of acute lung injury. PMID: 27010158 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



A multi-centre, open label, long-term follow-up study to evaluate the benefits of a new viscoelastic hydrogel (Hymovis®) in the treatment of knee osteoarthritis.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Results from this study confirm that Hymovis® alleviate the knee pain since the first treatment cycle. The patients treated with two cycles of intra-articular injections of Hymovis® have a progressive pain reduction that is maintained up to one year after the treatment start with improve of all the scores considered in this study. Hymovis® is effective and safe in symptomatic treatment of painful knee OA. PMID: 27010157 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Anti-inflammatory effects of three kinds of traditional Mongolian medicine monomer and its combination on LPS-stimulated RAW264.7 macrophages.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The Mongolia herbal compound exerts a potent anti-inflammatory effect and could potentially be developed as a useful agent for the chemo-prevention of inflammatory diseases. PMID: 27010156 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Antioxidant activities of Eryngium caucasicum inflorescence.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The results obtained indicated that all three extraction methods especially Soxhlet method could effectively extract antioxidants from this plant. PMID: 27010155 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Color Doppler ultrasonography in the evaluation of compensatory arteries in patients with moyamoya disease: combined with cerebral angiography.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Color duplex ultrasonography is a reliable, noninvasive and economic tool to assess hemodynamic changes of MA, STA and OA, and has prediction capability of these arteries formed compensatory arteries into intracranial. PMID: 27010154 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Serum levels of endocan, claudin-5 and cytokines in migraine.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: High serum levels of IL-1β, IL-6 and TNF-α in the migraine attack group indicate that inflammation plays a major role in migraine pathogenesis. In particular, the high ESM-1 and CLDN5 levels in patients with migraine suggest that inflammation should be investigated further, it may be a useful tool in the differential diagnosis of migraine. PMID: 27010153 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Plasma amino acid profile in autism spectrum disorder (ASD).

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Further studies are needed on the amino acids that show variations in children with ASD in order to reveal their role in the etiology and therapeutic use in ASD. PMID: 27010152 [PubMed - as supplied by publisher] (Source: European Review for Medical and Pharmacological Sciences)

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Long-term survival of full trisomy 13 in a 14 year old male: a case report.

Sat, 26 Mar 2016 11:11:03 +0100

We reported here the case of a 14-year-old male karyotype with full type of trisomy 13. In this clinical phenomenon, the case had typical facial, finger and limb anomalies for trisomy 13. Arterial septal defect and patent ductus arteriosus were recognized using ultrasonography after birth. Major cerebral malformation such as holoprosencephaly or cerebellar hypoplasia were also not revealed. After 5 months of his age, artificial ventilation therapy for dyspnea associated with laryngomalacia was required. A tracheotomy was performed at 6 months of his age. After 12 years old, intractable partial epilepsy was recognized. For his partial seizures, a treatment with a combination of two anti-epileptic drugs, valproic acid and levetiracetam, were advised. Now he is alive for 14-years-old and he i...



Early and late aortic propagation velocity values in STEMI patients after successful primary PCI and their relationship with neutrophil to lymphocyte ratio.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: We demonstrated for the first time that AVP values could improve after successful treatment in STEMI patients. The increment in AVP values was closely correlated with a decrement in neutrophil lymphocyte ratio. It can be postulated that AVP has strong correlations with the inflammatory markers. PMID: 27010150 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Value of the neutrophil-to-lymphocyte ratio in predicting post-pericardiotomy syndrome after cardiac surgery.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The postoperative NLR may be useful to predict the development of PPS in patients undergoing on-pump CABG. PMID: 27010149 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Effect of TGF-β1/SDF-1/CXCR4 signal on BM-MSCs homing in rat heart of ischemia/perfusion injury.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: TGF-β1 promotes homing of bone marrow (BM) MSCs in I/R injury's myocardial. The study provided useful data on the role of TGF-β1 in regulating SDF-1/CXCR4 axis-induced MSCs homing. PMID: 27010148 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Association of apelin, endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Endoglin, apelin and endocan may reflect angiogenesis and endothelial dysfunction in diabetic peripheral neuropathy and they may be used as a marker in the future. PMID: 27010147 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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The retinal nerve fiber layer, choroidal thickness, and central macular thickness in morbid obesity: an evaluation using spectral-domain optical coherence tomography.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: We have demonstrated by SD-OCT that morbid obesity may have a significant influence on RNFL, RGC, and CT. Morbid obesity may induce inflammatory, hormonal, and metabolic changes. PMID: 27010146 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Effect of cytochrome P450 2C19 polymorphisms on the Helicobacter pylori eradication rate following two-week triple therapy with pantoprazole or rabeprazole.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The genotypic polymorphism is effective on the rate of eradication. Eradication treatment rate with rabeprazole is influenced by CYP2C19 genotype. PMID: 27010145 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Early blood purification therapy of severe acute pancreatitis complicated by acute lung injury.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Early blood purification therapy improves respiratory function and inflammatory markers in patients with SAP complicated by ALI, and decreases the occurrence of MODS and ARDS. PMID: 27010144 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Cost-effectiveness of Lamivudine, Telbivudine, Adefovir Dipivoxil and Entecavir on decompensated hepatitis B virus-related cirrhosis.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: LMV, ADV, LdT, LMV+ADV and ETV were all effective on treatment of decompensated hepatitis B virus-related cirrhosis whereas ETV and LMV+ADV were recommended. PMID: 27010143 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Steroid-refractory inflammatory bowel disease is a risk factor for CMV infection.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: CMV infection should be suspected in steroid-resistant UC and CD. Antiviral treatment improved the clinical outcome in steroid-resistant IBD cases with serum CMV DNA levels above 1000 copies/mL. PMID: 27010142 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Study on JNK/AP-1 signaling pathway of airway mucus hypersecretion of severe pneumonia under RSV infection.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: MUC5AC and MUC5B can be used as marker molecules of airway mucus hypersecretion. Airway mucus hypersecretion of severe pneumonia induced by RSV might be related to the activation of JNK/AP-1 signaling pathway. PMID: 27010141 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Hypoxic markers in non-small cell lung cancer (NSCLC) - A review.

Sat, 26 Mar 2016 11:11:03 +0100

Authors: Xu FX, Zhang YL, Liu JJ, Zhang DD, Chen HB Abstract Surgery, chemotherapy and radiotherapy have been the main pillars of cancer treatment. Some of the recent improvements in survival of other cancers can be attributed to novel treatment therapies. Such therapies mostly target specific molecules involved in cancer progression and metastasis. Development and clinical introduction of targeted therapies involve identification of new and potentially important molecules in cancer progression. The next important step is to evaluate its prognostic value. Prognostication by molecular markers is also important as this may identify subgroups of patients in need for additional treatment or not, which was not possible with the traditional clinic-pathological prognosticators. Hypoxic ma...



Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The absence of differences in survival between hand-acral melanoma and foot-acral melanoma shows that the aggressiveness of the disease is related to distinct mutational rate, as well as to anatomical site-specific features, rather than to the visibility of the primary lesion. PMID: 27010139 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Diminished miR-613 expression as a novel prognostic biomarker for human ovarian cancer.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: miR-613 expression levels are low in ovarian cancer tissue and correlate with progression-free and overall survival. Thus, miR-613 may be useful as a prognostic marker in ovarian cancer. PMID: 27010138 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Mutational status of EZH2 and CD79B hot spots in mature B-cell non-Hodgkin's lymphomas: novel CD79B variations have been revealed.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: None of the patients had well-known hot spot mutations in EZH2 and CD79B. However, we detected novel CD79B variations in mature B-cell non-Hodgkin's lymphoma patients. PMID: 27010137 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Involvement of miR-454 overexpression in the poor prognosis of hepatocellular carcinoma.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: We firstly prove that expression of miR-454 may be a novel and valuable prognostic factor in HCC. PMID: 27010136 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer: a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV).

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended. PMID: 27010135 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Identification potential biomarkers and therapeutic agents in multiple myeloma based on bioinformatics analysis.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The genes such as CHEK1, MAD2L1, DBF4 and GBP1 may be potential therapeutic biomarkers in MM. Vinblastine may be a potential therapeutic agent in MM. PMID: 27010134 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Using 2D: 4D digit ratios to determine motor skills in children.

Sat, 26 Mar 2016 11:11:03 +0100

Authors: Wang Y, Wang HL, Li YH, Zhu FL, Li SJ, Ni H Abstract In past few decades, there has an outburst of research surrounding second to fourth finger digit ratio (2D:4D) and its relation to prenatal sex steroids including both testosterone and estrogen. In utero, testosterone and estrogen are responsible for the differences in digit ratio between the genders. Recent research has tried to extend past the influence of steroids and look at the potential effect of digit ratios on fine and gross motor skills in children. We compiled the current understanding of the connection between sex hormones and the development of the 2D:4D ratio as well as the effect the ratio has on motor skills. There seems to be a significant positive correlation between 2D:4D digit ratio and precision of fi...



The value of complete blood count parameters in predicting preterm delivery.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Although increased LMR levels were demonstrated to be associated with preterm birth and threatened preterm labor to be able to extrapolate these findings into clinical daily practice, further studies are needed. PMID: 27010132 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Pre-odontoblast proliferation induced by near-infrared laser stimulation.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Near infrared laser stimulation with low energies (1-10 J) is able to increase cell proliferation through ERK 1/2 signalling pathway activation. At the same time, higher energy stimulation (25-50 J) induces an initial toxic effect, probably activating pro-apoptotic signalling molecules, downstream ERK 1/2 kinase. Such results foster the application of this therapeutic approach in different clinical settings in which a regenerative tissue response is needed. PMID: 27010131 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Comment on "Peripheral blood used in place of bone marrow aspirate for detection of translocation t(11;14) status during minimal residual disease monitoring is cost-effectiveness".

Sat, 26 Mar 2016 11:11:03 +0100

Comment on "Peripheral blood used in place of bone marrow aspirate for detection of translocation t(11;14) status during minimal residual disease monitoring is cost-effectiveness". Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):792-3 Authors: Rainone DV PMID: 27010130 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



The role of the Ethics Committees in the application of the European Regulation No 536/2014.

Sat, 26 Mar 2016 11:11:03 +0100

Authors: Marinelli E, Busardò FP PMID: 27010129 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Erratum.

Sat, 26 Mar 2016 11:11:03 +0100

Authors: Wang DD, Liu ZW, Han MM, Zhu ZM, Tu YL, Dou CQ, Jin X, Cai SW, Du N Abstract In the article "Microarray based analysis of gene expression patterns in pancreatic neuroendocrine tumors", published in the European Review for Medical and Pharmacological Sciences 2015; 19(18): 3367-3374, some authors' names are wrong. The correct names are: D.-D. Wang, Z.-W. Liu, M.-M. Han, Z.-M. Zhu, Y.-L. Tu, C.-Q. Dou, X. Jin, S.-W. Cai, N. Du. PMID: 27010128 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Adverse Drug Event Reporting Systems‐a Systematic Review

Sat, 26 Mar 2016 05:22:12 +0100

ConclusionWe found substantial variability in the data fields used to report ADEs, limiting the comparability of ADE data collected using different reporting systems, and undermining efforts to aggregate data across cohorts. The development of a common standardized data set that can be evaluated with regard to data quality, comparability and reporting rates is likely to optimize ADE data and drug safety surveillance. (Source: British Journal of Clinical Pharmacology)

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Conference Report:5(th) International Conference on Nanotek & Expo, Nov 16-18, 2015, San Antonio TX, USA.

Fri, 25 Mar 2016 23:35:02 +0100

Authors: Sharma HS, Sharma A PMID: 27009119 [PubMed - in process] (Source: CNS and Neurological Disorders Drug Targets)



Commentary: Adaptive PTEN Loss Enhances the Outgrowth of Brain Metastatic Tumour Cells.

Fri, 25 Mar 2016 23:35:02 +0100

Authors: Kumar VS, Krishnamurthy RG PMID: 27009118 [PubMed - in process] (Source: CNS and Neurological Disorders Drug Targets)



Population pharmacokinetic analysis of patritumab, a HER3 inhibitor, in subjects with advanced non-small cell lung cancer (NSCLC) or solid tumors

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The PK of patritumab was linear at the doses studied and well described by the two-compartment model. Hepatic and renal impairment did not appear to affect PK. Our results support BW-based dosing of patritumab on a q3w schedule. (Source: Cancer Chemotherapy and Pharmacology)



Role of adjuvant therapy after R0 resection for patients with distal cholangiocarcinoma

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Our results show that patients receiving CT or CRT had significant improvements in OS and RFS. In addition, a benefit of adjuvant therapy (except RT alone) was observed even in LN-negative patients. (Source: Cancer Chemotherapy and Pharmacology)

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Overcoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinib

Fri, 25 Mar 2016 23:00:00 +0100

Abstract Myelofibrosis (MF) and polycythemia vera (PV) are BCR-ABL1-negative myeloproliferative neoplasms associated with somatic hematopoietic stem cell mutations leading to over activation of JAK–STAT signaling. MF and PV are pathogenically related and share specific clinical features such as splenomegaly and constitutional symptoms. The MF phenotype is dominated by the effects of progressive bone marrow fibrosis resulting in shortened survival. In contrast, elevated thrombosis risk due to erythrocytosis is the primary clinical concern in PV. Ruxolitinib, an oral JAK1/JAK2 inhibitor, is approved in the USA for the treatment of patients with intermediate- or high-risk MF and patients with PV who have had an inadequate response to or are intolerant of hydroxyurea. For MF, result...



Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: 30 April 2016 Source:International Journal of Pharmaceutics, Volume 503, Issues 1–2 Author(s): Mengchi Sun, Chunnuan Wu, Qiang Fu, Donghua Di, Xiao Kuang, Chao Wang, Zhonggui He, Jian Wang, Jin Sun The solvent-shift strategy was used to identify appropriate polymers that inhibit humidity-induced solid-state crystallization of amorphous solid dispersions (ASDs). Lacidipine with the polymers, PVP-K30, HPMC-E5 or Soluplus, were combined to form amorphous solid dispersions prepared by solvent evaporation. The formulations were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) and were subjected to in vitro dissolution testing. The moisture had a significant impact on the ...



How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Activation of circulating platelets and formation of “fibrinogen aggregates” in the presence of polycations

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: 30 April 2016 Source:International Journal of Pharmaceutics, Volume 503, Issues 1–2 Author(s): Cezary Watala, Kamil Karolczak, Hassan Kassassir, Marcin Talar, Tomasz Przygodzki, Katarzyna Maczynska, Magdalena Labieniec-Watala Direct use of poly(amido)amine (PAMAM) dendrimers as drugs may be limited, due to uncertain (cyto)toxicity. Peripheral blood components, which constitute the first line of a contact with administered pharmaceuticals, may become vastly affected by PAMAM dendrimers. The aim of this study was to explore how PAMAMs’ polycationicity might affect blood platelet activation and reactivity, and thus trigger various haemostatic events. We monitored blood platelet reactivity in rats with experimental diabetes upon a long-term administration of the ...



A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation

Fri, 25 Mar 2016 23:00:00 +0100

This article reviews the factors affecting the electrostatic charging of pharmaceutical powders with a focus on dry powder inhalations. The influences of particle resistivity, size distribution, shape distribution, surface roughness, polymorphic form and hygroscopicity, as well as the effects of moisture uptake, environmental conditions, pharmaceutical processing (i.e., milling, sieving, spray drying and blending), and storage on the electrostatic charge behaviours of pharmaceuticals, with focus on inhalation powders, were reviewed. The influence of electrostatic charge on the performance of dry powder inhaler formulations in terms of drug content homogeneity, the passage of drug through the inhaler device, drug–carrier adhesion/detachment, and drug deposition on the respiratory airways ...



Letter to Editor, International Journal of Pharmaceutics

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: 30 April 2016 Source:International Journal of Pharmaceutics, Volume 503, Issues 1–2 Author(s): W Seinen, R. Brands (Source: International Journal of Pharmaceutics)

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Ethnobotany, phytochemistry and neuropharmacological effects of Petiveria alliacea L. (Phytolaccaceae): A review

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Many traditional uses of P. alliacea have now been validated by modern pharmacology research. The available data reviewed here support the emergence of P. alliacea as a potential source for the treatment of different CNS disorders including anxiety, depression, pain, epilepsy and memory impairments. However, further studies are certainly required to improve the knowledge about the mechanisms of action, toxicity and efficacy of the plant as well as about its bioactive compounds before it can be approved in terms of its safety for therapeutic applications. Graphical abstract (Source: Journal of Ethnopharmacology)



Wild food plants used in traditional vegetable mixtures in Italy

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Nineteen edible wild plants, such as Asparagus albus L., Campanula trachelium L., Hypochaeris laevigata (L.) Benth. & Hook f., Phyteuma spicatum L., Scolymus grandiflorus Desf., are not yet studied as regards their phytochemical and nutritional profile. Some plants should be avoided due to the presence of toxic compounds such as Adenostyles alliariae (Gouan) A. Kern or Ranunculus repens L. Graphical abstract (Source: Journal of Ethnopharmacology)



Antimicrobial and antioxidant activity and chemical characterisation of Erythrina stricta Roxb. (Fabaceae)

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Seven compounds, including a new chromanone, were isolated from the antimicrobial dichloromethane extract of the stem bark of E. stricta. Six of the seven compounds showed antibacterial and/or antioxidant activities. These findings provide support for the customary (traditional and contemporary) use of E. stricta bark for the treatment of skin and wound infections. Graphical abstract (Source: Journal of Ethnopharmacology)



In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion: This study shows the potential transmission blocking activity of extracts from selected South African medicinal plants and substantiates their traditional use in malaria control that broadly encompasses prevention, treatment and transmission blocking. Further studies are needed to isolate and identify the active principles from the crude extracts of A. afra, T. emetica and T. floribunda, as well as to examine their efficacy towards blocking parasite transmission to mosquitoes. Graphical abstract (Source: Journal of Ethnopharmacology)

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Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion CAE of C. glaziovii exerts significant antiinflammatory and antioxidant activities and this effect can be attributed, at least in part, to the presence of chlorogenic acid and the C-glycosylflavonoids. Graphical abstract (Source: Journal of Ethnopharmacology)



Formation of copper(I) from trace levels of copper(II) as an artifactual impurity in the HPLC analysis of olanzapine

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: 5 June 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 125 Author(s): Steven W. Baertschi, Bernard A. Olsen, Timothy J. Wozniak, Nick Toltl, Colette O’Shea, Patrick J. Jansen An analytical artifact peak appearing to be an impurity was observed intermittently among several laboratories performing HPLC analyses of olanzapine drug substance and formulation samples. The artifact peak was identified as Cu(I) that was formed from the reaction of trace amounts of Cu(II) with olanzapine in the sample solution. Unlike Cu(II), Cu(I) was retained under the ion-pairing HPLC conditions used for analysis. A reaction mechanism was postulated whereby Cu(II) present in the sample solution oxidizes olanzapine to a radical-cation, resulting in formation of Cu...



Inhibition of extracellular matrix production and remodeling by Doxycycline in Smooth Muscle Cells

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 25 March 2016 Source:Journal of Pharmacological Sciences Author(s): Rogelio Palomino-Morales, Carolina Torres, Sonia Perales, Ana Linares, Maria Jose Alejandre Alterations in the extracellular matrix (ECM) production and remodeling of smooth muscle cells (SMCs) have been implicated in processes related to the differentiation in atherosclerosis. Due to the anti-atherosclerotic properties of the tetracyclines, we aimed to investigate whether cholesterol supplementation changes the effect of doxycycline over the ECM proteins synthesis and whether isoprenylated proteins and Rho A protein activation are affected. SMC primary culture isolated from chicks exposed to atherogenic factors in vivo (a cholesterol-rich diet, SMC-Ch), comparing it with control c...



Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Steroids Author(s): B. Sathish Kumar, Dushyant Singh Raghuvanshi, Mohammad Hasanain, Sarfaraz Alam, Jayanta Sarkar, Kalyan Mitra, Feroz Khan, Arvind S. Negi 2-methoxyestradiol (2ME2), an estrogen hormone metabolite is a potential cancer chemotherapeutic agent. Presently, it is an investigational drug under various phases of clinical trials alone or in combination therapy. Its anticancer activity has been attributed to its antitubulin, antiangiogenic, pro-apoptotic and ROS induction properties. This anticancer drug candidate has been explored extensively in last twenty years for its detailed chemistry and pharmacology. Present review is an update of its chemistry and biological activity. It also extends an assessment of poten...



Biotransformation of dehydro-epi-androsterone by Aspergillus parasiticus: metabolic evidences of BVMO activity

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Steroids Author(s): M. Laura Mascotti, Martín A. Palazzolo, Fabricio R. Bisogno, Marcela Kurina-Sanz The research on the synthesis of steroids and its derivatives is of high interest due to their clinical applications. A particular focus is given to molecules bearing a D-ring lactone like testolactone because of its bioactivity. The Aspergillus genus has been used to perform steroid biotransformations since it offers a toolbox of redox enzymes. In this work, the use of growing cells of A. parasiticus to study the bioconversion of dehydro-epi-androsterone (DHEA) is described, emphasizing the metabolic steps leading to D-ring lactonization products. It was observed that A. parasiticus is not only capable of transforming bicyclo[3...



Expression of 11beta-hydroxysteroid-dehydrogenase type 2 in human thymus

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Steroids Author(s): Giovanni Almanzar, Christina Mayerl, Jan-Christoph Seitz, Kerstin Höfner, Andrea Brunner, Vanessa Wild, Daniel Jahn, Andreas Geier, Martin Fassnacht-Capeller, Martina Prelog 11beta-hydroxysteroid-dehydrogenase type 2 (11β-HSD2) is a high affinity dehydrogenase which rapidly inactivates physiologically-active glucocorticoids to protect key tissues. 11β-HSD2 expression has been described in peripheral cells of the innate and the adapative immune as well as in murine thymus. In absence of knowledge of 11β-HSD2 expression in human thymus, the study aimed to localize 11β-HSD2 in human thymic tissue. Thymic tissue was taken of six healthy, non-immunologically impaired male infants below 12 months of age ...



Cutaneous abscess due to Gordonia bronchialis: case report and literature review.

Fri, 25 Mar 2016 23:00:00 +0100

Authors: Bartolomé-Álvarez J, Sáez-Nieto JA, Escudero-Jiménez A, Barba-Rodríguez N, Galán-Ros J, Carrasco G, Muñoz-Izquierdo MP PMID: 27015823 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)



[Moraxella osloensis peritonitis : Case report and review].

Fri, 25 Mar 2016 23:00:00 +0100

Authors: Hernández-Egido S, Puerta-Mateo A, Cores-Calvo O, Ruiz-Ferraras E PMID: 27015822 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)



[Linezolid-resistant Staphylococcus epidermidis in a patient with prosthetic joint].

Fri, 25 Mar 2016 23:00:00 +0100

Authors: Zamora-López MJ, Álvarez-García P, Martínez-López J, Pallarés-González MA, García-Campello M PMID: 27015821 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)

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Natural chemopreventive alternatives in oral cancer chemoprevention.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Scrobota I, Bolfa P, Filip AG, Catoi C, Alb C, Pop O, Tatomir C, Baciut G Abstract We studied the effect of grape seed extract Burgund Mare (BM) on oral carcinogenesis and compared it with that of curcumin (CU). Wistar rats were divided into six groups (n = 10): 4-nitro-quinoline-1-oxide (4NQO) oral carcinogenesis was induced to groups 1 - 5; groups 2 and 3 received BM and CU respectively during initiation and groups 4 and 5 BM and CU during post-initiation of carcinogenesis; group 6 represented the negative control group. Total malondialdehyde (MDA) and reduced glutathione (GSH) were assayed fluorometrically in oral tissue (gingival, jugal, palatal, lingual mucosa) and serum. Histopathological exam was performed and a dysplasia score given to each oral mucosal lesion. Ki6...



Expression of neurotrophins and their receptors in human CD34+ bone marrow cells.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Paczkowska E, Piecyk K, Luczkowska K, Kotowski M, Roginska D, Pius-Sadowska E, Oronowicz K, Ostrowski M, Machalinski B Abstract Bone marrow (BM) CD34+ cells have the ability to secrete growth factors, cytokines, and chemotactic factors. We sought to better characterize this population and to investigate whether human BM CD34+ cells express neurotrophins (NTs) and their relevant receptors. We also compared their expression levels with BM nucleated cells (NCs). BM CD34+ cells were evaluated with respect to the expression levels of neurotrophins using qRT-PCR, immunofluorescent staining, and Western blotting. Next, the expression of specific (TrkA, TrkB, TrkC) and non-specific (p75NTR) neurotrophin receptors was detected by qRT-PCR and immunofluorescent staining in BM CD34+ c...



Changes in contractile properties and action potentials of motor units in the rat medial gastrocnemius muscle during maturation.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Dobrzynska Z, Celichowski J Abstract The early phase of development of muscles stops following the disappearance of embryonic and neonatal myosin and the elimination of polyneuronal innervation of muscle fibres with the formation of motor units (MUs), but later the muscle mass still considerably increases. It is unknown whether the three types are visible among newly formed MUs soon after the early postnatal period and whether their proportion is similar to that in adult muscle. Moreover, the processes responsible for MU-force regulation by changes in motoneuronal firing rate as well as properties of motor unit action potentials (MUAPs) during maturation are unknown. Three groups of Wistar rats were investigated - 1 month old, 2 months old and the adult, 9 months old. The ...

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Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress by suppressing abnormal testicular matrix metalloproteinase system via the Notch 2/Jagged 1/Hes-1 and caspase-8 pathways.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Al-Maghrebi M, Renno WM Abstract The aim of the study is to examine the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMP) during testicular ischemia/reperfusion (t I/R). The involvement of the Notch pathway, and their modulation by the antioxidant genistein is also studied. Three groups of male Sprague-Dawley rats were used: sham rats, t I/R rats, and genistein-treated rats (10 mg/kg). The t I/R rat model underwent testicular artery occlusion of the left testis and was subjected to 60 min ischemia followed by 4 h reperfusion. Protein expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured in testicular tissue. Histological examination was performed to assess spermatogenesis. Protein levels of Notch 2, Jagged 1, and hairy/enhancer of split 1 (hes-1) ...



Pharmacological characterization of lipidized analogs of prolactin-releasing peptide with a modified C- terminal aromatic ring.

Fri, 25 Mar 2016 19:51:02 +0100

In this study, myristoylated and palmitoylated PrRP31 analogs with a modified C-terminal Phe were designed and tested. Lipidized analogs containing Phe(31) replaced by aromatic non-coded amino acids or tyrosine revealed high binding affinity to rat pituitary RC-4B/C cells with endogenous PrRP and neuropeptide FF 2 receptors and to CHO-K1 cells overexpressing either PrRP or neuropeptide FF 2 receptors. The analogs also showed strong agonistic properties at the GPR10 receptor using the beta-lactamase reporter gene assay. Moreover, lipidized PrRP analogs, especially those that were palmitoylated, demonstrated strong and long-lasting anorexigenic effects in fasted mice after subcutaneous administration. The most efficient PrRP31 analogs with PheCl2(31), either palmitoylated or myristoylated at...



Dynamics of the melatonin MT1 receptor in the rat parotid gland upon melatonin administration.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Isola M, Ekstrom J, Lilliu MA, Isola R, Loy F Abstract Our recent ultrastructural study of human parotid glands revealed that the melatonin receptors, MT1 and MT2, are localised in the plasma cell membranes of acinar and ductal cells but also, and intriguingly, predominantly in acinar secretory granules, giving rise to the working hypothesis that secretory granules are a part of a transcytotic transport system for melatonin. To put this hypothesis to the test in rat parotid glands, anaesthetised animals were exposed to a high melatonin dose (3 mg/kg per hour), infused intravenously over two hours and aiming to stimulate a glandular melatonin-receptor-dependent intracellular transport system, if any. Thirty minutes later, the right parotids were removed. Pre-stimulation, le...



Effects of renin-angiotensin system inhibitors on fibrosis in patients with alcoholic chronic pancreatitis.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Madro A, Kurzepa J, Celinski K, Slomka M, Czechowska G, Kurzepa J, Kazmierak W, Buszewicz G, Ciesielka M, Madro R Abstract Chronic pancreatitis (CP) results in impairment of exocrine as well as endocrine functions and progressive fibrosis. Previous studies, have demonstrated the presence of renin-angiotensin system receptors within different pancreatic cells. The aim of the present study was to assess the effects of renin-angiotensin system (RAS) inhibitors on serum levels of fibrosis biomarkers (matrix metalloproteinase 2 and 9 (MMP-2, MMP-9), tissue inhibitor of MMP (TIMP- 1, TIMP-2), hyaluronic acid (HA)) and fasting glucose levels in patients with alcoholic CP. Seventy seven outpatients (mean age 43 years, 62 males) with diagnosed alcoholic CP were randomly enrolled in...



The role of the tissue plasminogen activator as a prognostic and differentiation factor in patients with pancreatic canceer and chronic pancreatitis.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Baluka D, Urbanek T, Lekstan A, Swietochowska E, Wiaderkiewicz R, Kajor M, Jedrzejewska-Szypulka H, Kusnierz K, Lampe P Abstract Unsatisfactory pancreatic cancer treatment outcomes have prompted multiple avenues of research focused on identifying not only biomarkers of pancreatic adenocarcinoma progression but also potential prognostic survival factors in patients with pancreatic adenocarcinoma. Study consisted of 75 patients who underwent pancreatic resections between 2006 and 2011: 35 patients with pancreatic ductal adenocarcinoma (PC), 30 patients with chronic pancreatitis (CP), and a non-malignant control group (NMCG) of 10 patients who underwent surgery due to benign tumors. Tissue plasminogen activator (t-PA) concentrations in tissue homogenates and sera were evaluat...

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The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Pawlik MW, Kwiecien S, Ptak-Belowska A, Pajdo R, Olszanecki R, Suski M, Madej J, Targosz A, Konturek SJ, Korbut R, Brzozowski T Abstract The inhibition of angiotensin-converting enzyme (ACE) or the blockade of angiotensin (Ang) AT-1 receptors affords protection against acute gastric mucosal injury, but whether the major metabolite of renin-angiotensin system (RAS), Ang-(1-7), accelerates the healing process of preexisting gastric ulcers remains unknown. Previous studies documented that Ang-(1-7) acting via its own Mas receptor exerts vascular responses opposing those of Ang II. We studied the effects of the Ang-(1-7)/Mas receptor axis on the healing rate of acetic-acid-induced gastric ulcers with or without the blockade of Mas receptors by A 779 and compared it with the ef...



Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats.

Fri, 25 Mar 2016 19:51:02 +0100

In conclusion, the histaminergic system is involved in centrally-acting leptin-induced resuscitating effect in haemorrhagic shock in rats. PMID: 27010896 [PubMed - as supplied by publisher] (Source: Journal of Physiology and Pharmacology)



Effects of surfactant/budesonide therapy on oxidative modifications in the lung in experimental meconium-induced lung injury.

Fri, 25 Mar 2016 19:51:02 +0100

In conclusion, budesonide added into surfactant enhanced effect of therapy on oxidative damage of the lung. PMID: 27010895 [PubMed - as supplied by publisher] (Source: Journal of Physiology and Pharmacology)



Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Kumral ZN, Sener G, Ozgur S, Koc M, Suleymanoglu S, Hurdag C, Yegen BC Abstract The importance of physical activity in the management of renovascular diseases is well-known, but lacks evidence of underlying mechanisms. The purpose of the study was to elucidate the protective/therapeutic effects of regular exercise on experimental renovascular hypertension (RVH)-induced oxidative stress and cardiac dysfunction. Wistar albino rats underwent a RVH surgery (2K1C, Goldblatt). Three weeks later half of the rats started swimming exercise for 9 weeks (n = 15), while the sedentary RVH group (n = 15) had no exercise during that period. Sham-operated control rats (n = 10), had the similar surgical procedures but the left renal artery was left unclipped. Body weights were monitored, a...



Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Ahmad A, Sattar MA, Rathore HA, Abdulla MH, Khan SA, Abdullah NA, Johns EJ Abstract The present study investigated the role of endothelial nitric oxide synthase (eNOS) enzyme in the development of left ventricular hypertrophy (LVH) in Wistar-Kyoto rats. The effect of L-arginine administration on cardiac structure, arterial stiffness, renal and systemic hemodynamic parameters was studied and the change in expression of eNOS and cystathione γ lyase (CSE) in the myocardium of LVH rats was evaluated. LVH was induced using isoprenaline (5 mg/kg, S.C.) and caffeine (62 mg/L in drinking water) for 14 days. Following to that, L-arginine (1.25g/L in drinking water) was given for 5 weeks as a donor of NO. eNOS and CSE gene expressions were down regulated in the LVH group by about 3...

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Latest aspects of aldosterone actions on the heart muscle.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Kritis AA, Gouta CP, Liaretidou EI, Kallaras KI Abstract The genomic action of aldosterone has already been known to the scientific community and is well-documented to a satisfactory degree. However, the existence of rapid, non-genomic aldosterone actions has repeatedly been proven. These actions are apparent to a lot of tissues, among which the cardiac tissue, with the cardiac cells being responsible for the secretion of endogenous aldosterone. In the genomic pathway, the connection between the hormone and its receptor results increased reabsorption of sodium and water and excretion of potassium. Thus, the genomic procedure reacts indirectly on cardiovascular system by altering the blood pressure. New studies have shed light on unknown aspects of the non-genomic mechanism...



Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Majewski M, Kozlowska A, Thoene M, Lepiarczyk E, Grzegorzewski WJ Abstract The kynurenine pathway (KP) of L-tryptophan metabolism produces several neuroactive metabolites with an amino acid structure. These metabolites may play an important role in the pathophysiology of irritable bowel syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia, AIDS-dementia complex, depression, epilepsy and the aging process. Modulation of the KP through inhibition or stimulation of enzyme synthesis and activity can be an alternative approach to traditional therapy. Furthermore, it may be responsible for the altered functioning of the enteric nervous system and the central nervous system. There is evidence that the KP is sensitive to changes in the concentrat...



Cefazolin Injection (Updated - Currently in Shortage)

Fri, 25 Mar 2016 18:00:00 +0100

Updated Drug Shortage (Source: FDA Drug Shortages)



Cefepime Injection (Updated - Currently in Shortage)

Fri, 25 Mar 2016 18:00:00 +0100

Updated Drug Shortage (Source: FDA Drug Shortages)



Chloroquine Phosphate Tablets (Updated - Resolved)

Fri, 25 Mar 2016 18:00:00 +0100

Updated Drug Shortage (Source: FDA Drug Shortages)



FDA Drug Safety Communication: No increase in risk of cancer with certain blood pressure drugs--Angiotensin Receptor Blockers (ARBs)

Fri, 25 Mar 2016 15:17:00 +0100

[06-02-2011] The U.S. Food and Drug Administration (FDA) has completed a review of the potential risk of cancer associated with the class of medications known as angiotensin receptor blockers (ARBs). FDA has concluded that treatment with an ARB medication does not increase a patient’s risk of developing cancer. (Source: FDA Center for Drug Evaluation and Research - What's New)



FDA Drug Safety Communication: Eosinophilic pneumonia associated with the use of Cubicin (daptomycin)

Fri, 25 Mar 2016 15:10:00 +0100

[07-29-2010] The U.S. Food and Drug Administration (FDA) is informing patients and healthcare professionals about the potential for developing eosinophilic pneumonia during treatment with Cubicin (daptomycin), an intravenous antibacterial drug. (Source: FDA Center for Drug Evaluation and Research - What's New)

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FDA Drug Safety Communication: Serious medication errors from intravenous administration of nimodipine oral capsules

Fri, 25 Mar 2016 14:49:00 +0100

[08-02-2010] The U.S. Food and Drug Administration (FDA) is alerting healthcare professionals that nimodipine capsules should be given ONLY by mouth or through a feeding tube (nasogastric tube). (Source: FDA Center for Drug Evaluation and Research - What's New)



FDA Drug Safety Communication: Aseptic meningitis associated with use of Lamictal (lamotrigine)

Fri, 25 Mar 2016 14:23:00 +0100

[08-12-2010] The U.S. Food and Drug Administration (FDA) is informing the public that Lamictal (lamotrigine)†, a medication commonly used for seizures in children two years and older, and bipolar disorder in adults, can cause aseptic meningitis. (Source: FDA Center for Drug Evaluation and Research - What's New)



FDA Drug Safety Communication: FDA recommends against the continued use of propoxyphene

Fri, 25 Mar 2016 13:45:00 +0100

The U.S. Food and Drug Administration (FDA) is recommending against continued prescribing and use of the pain reliever propoxyphene because new data show that the drug can cause serious toxicity to the heart, even when used at therapeutic doses. (Source: FDA Center for Drug Evaluation and Research - What's New)



FDA Drug Safety Communication: Safety update for osteoporosis drugs, bisphosphonates, and atypical fractures

Fri, 25 Mar 2016 12:51:00 +0100

[10-13-2010] The U.S. Food and Drug Administration (FDA) is updating the public regarding information previously communicated describing the risk of atypical fractures of the thigh, known as subtrochanteric and diaphyseal femur fractures, in patients who take bisphosphonates for osteoporosis. (Source: FDA Center for Drug Evaluation and Research - What's New)



Coffee Consumption and the Risk of CirrhosisCoffee Consumption and the Risk of Cirrhosis

Fri, 25 Mar 2016 12:34:28 +0100

Are coffee drinkers at an increased risk of cirrhosis or does the opposite hold true? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)

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