Last Build Date: Mon, 28 Mar 2016 06:25:32 +0100
Sun, 27 Mar 2016 09:51:02 +0100This article reviews the recognition and management of asthma and allergic rhinitis during pregnancy, paying close attention to the general principles of allergy and use of asthma medication during pregnancy. Both allergic rhinitis and asthma can adversely affect both maternal quality of life and, in the case of maternal asthma, perinatal outcomes. Optimal management is thus important for both mother and baby. This article reviews the safety of asthma and allergy medications commonly used during pregnancy. PMID: 27012010 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Sun, 27 Mar 2016 03:07:01 +0100Authors: Coutinho Nunes F, Domingues AP, Vide Tavares M, Belo A, Ferreira C, Fonseca E, Moura P Abstract This prospective cohort study compared obstetric, perinatal and postpartum outcomes of monochorionic diamniotic (n = 228) versus (vs.) dichorionic (n = 598) twin pregnancies. Statistical analysis was performed using software SPSS® v184.108.40.206. Chi square, Fischer's exact, Student's t and Mann-Withney tests were applied. Obstetrical complications rates were 85.5% vs. 75.1% (p < 0.01). Differences were found in preterm premature rupture of membranes (26.3% vs. 19.3%, p < 0.05) and intrauterine growth restriction (19.7% vs. 10.5%, p < 0.01). Twin-to-twin transfusion syndrome (TTTS) occurred in 7.9% of monochorionic pregnancies. Vaginal delivery occurred ...
Sat, 26 Mar 2016 23:00:00 +0100Publication date: Available online 26 March 2016 Source:Journal of Neonatal Nursing Author(s): Chisako Morii Unplanned extubation in neonatal intensive care units is one of the common adverse events for the mechanically ventilated infants. This is a significant patient safety issue and the prevention is very important for both infants and organisations. The purpose of this review is to explore and identify the prevention strategies for unplanned extubation in literature. This literature review discussed prevention strategies in terms of endotracheal tube fixation, use of sedation, use of physical restraints, nursing workload, and quality improvement programme/project. There was limited research in neonatal populations. However, future research and some prevention practices would be bene...
Sat, 26 Mar 2016 10:06:02 +0100Authors: Koshida S, Ono T, Tsuji S, Murakami T, Takahashi K Abstract Multiple pregnancies (twin, triplet, and higher-order pregnancy) are associated with an increased risk of resultant preterm and low birth weight infants. The increase of multiple pregnancies for several decades in Japan has been an important consideration in bed allocation planning for neonatal intensive care unit (NICU). The guideline of the Japan Society of Obstetrics and Gynecology (JSOG) in 2008 recommended that embryo transfer be limited to one. The epidemiological data of Japanese regional multiple pregnancies before the JSOG recommendation are valuable in assessing the perinatal effects after this recommendation. The aim of this study was to investigate regional backgrounds of multiple pregnancies and neona...
Fri, 25 Mar 2016 23:00:00 +0100We present a case of meconium peritonitis with emergent cesarean section delivery after the patient developed massive meconium ascites, hydrops fetalis, and non-reassuring fetal monitoring. In the immediate postnatal period, the patient was intubated and a peritoneal drain was placed for respiratory and hemodynamic stabilization. He was then taken to the operating room the following day for laparotomy and bowel resection. His post-operative course was uneventful, and he was discharged home in good clinical condition. (Source: Journal of Pediatric Surgery Case Reports)
Fri, 25 Mar 2016 23:00:00 +0100Supporting the respiratory status of the newly born, critically ill premature neonate is a long held focus of the practicing neonatologist. One could argue that neonatology evolved out of the search for the pathophysiology of respiratory distress syndrome (RDS); and that it was defined by interventions aimed at preventing and treating RDS, namely antenatal corticosteroids (ACS) and surfactant treatment. There are now multiple interventions to assist the premature infant during this transition including ACS, surfactant, monitored administration of supplemental oxygen, and sophisticated mechanical ventilators. (Source: The Journal of Pediatrics)
Fri, 25 Mar 2016 23:00:00 +0100This article gives an overview of the key considerations to be incorporated in to this period, and reviews the latest evidence base behind recommendations including thermoregulatory support, delayed cord clamping, oxygen supplementation, PEEP versus intubation, and the role of surfactant. (Source: Paediatrics and Child Health)
Fri, 25 Mar 2016 19:51:02 +0100Authors: Dobrzynska Z, Celichowski J Abstract The early phase of development of muscles stops following the disappearance of embryonic and neonatal myosin and the elimination of polyneuronal innervation of muscle fibres with the formation of motor units (MUs), but later the muscle mass still considerably increases. It is unknown whether the three types are visible among newly formed MUs soon after the early postnatal period and whether their proportion is similar to that in adult muscle. Moreover, the processes responsible for MU-force regulation by changes in motoneuronal firing rate as well as properties of motor unit action potentials (MUAPs) during maturation are unknown. Three groups of Wistar rats were investigated - 1 month old, 2 months old and the adult, 9 months old. The ...
Fri, 25 Mar 2016 16:22:21 +0100Abstract Renal transplantation (RTx) has become an accepted mode of therapy in infants with severe renal failure. The major indications are structural abnormalities of the urinary tract, congenital nephrotic syndrome, polycystic diseases, and neonatal kidney injury. Assessment of these infants needs expertise and time as well as active treatment before RTx to ensure optimal growth and development, and to avoid complications that could lead to permanent neurological defects. RTx can be performed already in infants weighing around 5 kg, but most operations occur in infants with a weight of 10 kg or more. Perioperative management focuses on adequate perfusion of the allograft and avoidance of thrombotic and other surgical complications. Important long-term issues include rejection...
Fri, 25 Mar 2016 16:13:53 +0100[Abstract unavailable] Language: en... (Source: SafetyLit)
Fri, 25 Mar 2016 13:36:47 +0100Parents of very premature babies are more worried about their grown up children's lives than mothers and fathers whose babies were born full term. (Source: ScienceDaily Headlines)
Fri, 25 Mar 2016 12:44:16 +0100According to this study: * Only about 20% of women who are told that their babies may be large (8 lbs. or more) actually deliver large babies. * Communicating concerns about fetal size to parents influences their perceptions about the pregnancy and leads to greater use of perinatal interventions, including medically induced labor or attempts at self-induced labor and planned cesarean section. (Source: AJN)
Fri, 25 Mar 2016 11:13:48 +0100Objective: Pruritus is a common symptom of cholestatic liver disorders. The present study aimed at evaluating autotaxin (ATX), a lysophospholipase recently identified as potential cause for cholestatic pruritus, in pediatric cholestatic diseases presenting with or without itching. Methods: A cohort of 45 children consisting of 14 patients experiencing itching (Alagille syndrome [n = 10], complete extrahepatic biliary atresia [n = 2], neonatal sclerosing cholangitis (n = 1), progressive familial intrahepatic cholestasis type 2 [n = 1]), 9 patients with bile acid synthesis defects (3β-hydroxy-C27-steroid-oxidoreductase [n = 7] and Δ4–3-oxosteroid-5β-reductase deficiency [n = 2]), and 22 healthy children were studied. Serum ATX activity and total serum bile salt ...
Fri, 25 Mar 2016 04:00:00 +0100(University of Warwick) Parents of very premature babies are more worried about their grown up children's lives than mothers and fathers whose babies were born full term. (Source: EurekAlert! - Social and Behavioral Science)
Fri, 25 Mar 2016 00:00:00 +0100Mevalonate kinase deficiency is a metabolic autoinflammatory syndrome caused by mutations in the MVK gene, mevalonate kinase, the key enzyme in the non-sterol isoprenoid biosynthesis pathway. Two phenotypes of me... (Source: Pediatric Rheumatology)
Thu, 24 Mar 2016 23:00:00 +0100Publication date: Available online 25 March 2016 Source:Journal of Neonatal Nursing Author(s): Judy Hitchcock (Source: Journal of Neonatal Nursing)
Thu, 24 Mar 2016 23:00:00 +0100Publication date: Available online 24 March 2016 Source:Stem Cell Reports Author(s): Ebrahim Shahbazi, Sharif Moradi, Shiva Nemati, Leila Satarian, Mohsen Basiri, Hamid Gourabi, Narges Zare Mehrjardi, Patrick Günther, Angelika Lampert, Kristian Händler, Firuze Fulya Hatay, Diana Schmidt, Marek Molcanyi, Jürgen Hescheler, Joachim L. Schultze, Tomo Saric, Hossein Baharvand Direct conversion of somatic cells into neural stem cells (NSCs) by defined factors holds great promise for mechanistic studies, drug screening, and potential cell therapies for different neurodegenerative diseases. Here, we report that a single zinc-finger transcription factor, Zfp521, is sufficient for direct conversion of human fibroblasts into long-term self-renewable and multipotent NSCs. In ...
Thu, 24 Mar 2016 23:00:00 +0100Publication date: Available online 25 March 2016 Source:Autoimmunity Reviews Author(s): Adrian W. Zuercher, Rolf Spirig, Adriana Baz Morelli, Fabian Käsermann Polyclonal plasma-derived IgG is a mainstay therapeutic of immunodeficiency disorders as well as of various inflammatory autoimmune diseases. In immunodeficiency the primary function of IVIG/SCIG is to replace missing antibody specificities, consequently a diverse Fab-based repertoire is critical for efficacy. Attempts to capture the Ig repertoire and express it as a recombinant IVIG product are currently ongoing. Likewise correction of the defective genes by gene therapy has also been tried. However, both approaches are far from becoming mainstream treatments. In contrast, some of the most important effector mechanisms releva...
Thu, 24 Mar 2016 23:00:00 +0100Conclusion Acceleration forces of pediatric and neonatal interfacility transport are small and comparable in magnitude. The relationship between rSO2 drop and patient positioning was not significant in this pilot study. (Source: Air Medical Journal)
Thu, 24 Mar 2016 23:00:00 +0100Question: An otherwise healthy 7-year-old boy presented to the gastroenterology clinic with a history of longstanding constipation and encopresis. The past medical history was significant for an intermediate level anal bar causing an imperforate anus, requiring a minor anoplasty in the neonatal period. The family and pregnancy history were noncontributory. (Source: Gastroenterology)
Thu, 24 Mar 2016 23:00:00 +0100ConclusionsThe incidence of CDH in Croatia is within the range of previous reports. Survival was substantially higher in neonates treated in a centre with higher case volume, which suggests that centralisation of medical care for CDH may be warranted in Croatia. (Source: Paediatric and Perinatal Epidemiology)
Thu, 24 Mar 2016 23:00:00 +0100Few studies have reported odds of mortality for hospitalized premature infants stratified by postnatal age and adjusted for severity of illness. Our objective was to examine day-by-day mortality of premature infants in a large multicenter cohort of infants, adjusted for demographics, severity of illness, and receipt of therapeutic interventions. (Source: Early Human Development)
Thu, 24 Mar 2016 23:00:00 +0100CONCLUSION: Our results suggest a critical balance between TNF-α and TGF-β signaling in the developing lung, and underscore the critical importance of these key pathways in the pathogenesis of BPD. Future treatment strategies need to weigh the potential benefits of inhibiting pathologic cytokine expression against the potential of altering key developmental pathways. PMID: 27016588 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Thu, 24 Mar 2016 18:14:02 +0100Authors: PMID: 27003479 [PubMed - in process] (Source: Advances in Neonatal Care)
Thu, 24 Mar 2016 18:14:02 +0100Authors: Manipon C Abstract BACKGROUND: Our current culture defines breastfeeding and the use of human breast milk as the preferred criterion standard for infant nutrition. Medical and health professionals have a responsibility to support breastfeeding in the mother-infant dyad. This includes the recognition of anatomical barriers to breastfeeding such as a tongue-tie, ankyloglossia. PURPOSE: The purpose of this article is to enrich and expand the clinical knowledge of health professionals about the physical assessment of ankyloglossia and its impact on breastfeeding. Techniques for assessing anterior and posterior ankyloglossia and interventions across the spectrum are discussed. We also explore maternal emotional experiences of breastfeeding an infant with ankyloglossia. ...
Thu, 24 Mar 2016 18:14:02 +0100Authors: PMID: 27003477 [PubMed - in process] (Source: Advances in Neonatal Care)
Thu, 24 Mar 2016 18:14:02 +0100Authors: PMID: 27003476 [PubMed - in process] (Source: Advances in Neonatal Care)
Thu, 24 Mar 2016 13:25:02 +0100CONCLUSION: A prophylactic regimen that included nelfinavir, lamivudine, and zidovudine was used to prevent perinatal transmission of HIV in two neonates. The regimen was well tolerated, and both infants were determined to be HIV-negative at four months of age. PMID: 27001986 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Thu, 24 Mar 2016 11:01:02 +0100Authors: Sołowiej P, Kowalczyk M, Szymkiewicz-Dangel J PMID: 27004548 [PubMed - in process] (Source: Kardiologia Polska)
Thu, 24 Mar 2016 06:13:06 +0100Journal Name: Journal of Perinatal MedicineIssue: Ahead of print (Source: Journal of Perinatal Medicine)
Wed, 23 Mar 2016 23:00:00 +0100We present an analysis of equity improvements after the implementation of a Community Based Newborn Care Package (CB-NCP) in the Bardiya district of Nepal. The package was implemented alongside other programs that were already in place within the district. We present changes in concentration indices (CIndices) as measures of changes in equity, as well as percentage changes in coverage, between baseline and endline. The CIndices were derived from wealth scores that were based on household assets, and they were compared using t-tests. We observed statistically significant improvements in equity for facility delivery [CIndex: –0.15 (–0.24, –0.06)], knowledge of at least three newborn danger signs [–0.026(–0.06, –0.003)], breastfeeding within 1 h [–0.0...
Wed, 23 Mar 2016 23:00:00 +0100Conclusion. Our study suggests that the introduction of a user-fee subsidy in Burkina Faso resulted in increased rates of SBA across all SES strata. The increase was sustained over time and strongest among the poorest women. These findings have important implications for evidence-informed policymaking in Burkina Faso and other countries in Sub-Saharan Africa. (Source: Health Policy and Planning)
Wed, 23 Mar 2016 23:00:00 +0100This study is part of an ex-ante evaluation of a feasibility study of the MCH Voucher Scheme. A cost-utility analysis was conducted using a decision tree model to assess the cost per disability-adjusted life years (DALYs) averted from the MCH Voucher Scheme compared with the current situation. Most input parameters were obtained from Myanmar context. From the base-case analysis, where the financial burden on households was fully subsidized, the MCH Voucher Scheme increased utilization for ANC from 73% up to 93% and for delivery from SBAs from 51% up to and 71%, respectively; hence, it is considered to be very cost-effective with an incremental cost-effectiveness ratio of 381 027 kyats per DALY averted (2010, price year). From the probabilistic sensitivity analysis, the MCH Voucher Scheme h...
Wed, 23 Mar 2016 23:00:00 +0100Authors: J C Wei, R Catalano, J Profit, J B Gould & H C Lee (Source: Journal of Perinatology)
Wed, 23 Mar 2016 23:00:00 +0100Authors: E Maciejewski, I Hamon, J Fresson & J-M Hascoet (Source: Journal of Perinatology)
Wed, 23 Mar 2016 23:00:00 +0100Publication date: 21 April 2016 Source:Neuroscience Letters, Volume 619 Author(s): Mete Ozcan, Zeynep Betul Gok, Emine Kacar, Ihsan Serhatlioglu, Haluk Kelestimur Nesfatin-1 is a recently identified anorexigenic hypothalamic polypeptide derived from the posttranslational processing of nucleobindin 2 (NUCB2). Several studies have indicated that this neuropeptide may be participated in somatosensory and visceral transmission including pain signals in addition to energy metabolism. The aim of this study was to explore the possible role of nesfatin-1 in the transmission of peripheral neural signals by investigating the effects of nesfatin-1 on intracellular free calcium levels ([Ca2+]i) in cultured neonatal rat dorsal root ganglion (DRG) neurons. The effects of nesfatin-1 on [Ca2+]i in ...
Wed, 23 Mar 2016 23:00:00 +0100We report a case of acute otitis externa in a 29-day-old, term, otherwise healthy neonate. Swab cultures revealed growth of Methicillin-sensitive Staphylococcus aureus colonies. She was successfully treated with parenteral cloxacillin and had no complication and recurrence. No cases of neonatal acute otitis externa have been previously reported (Source: International Journal of Pediatric Otorhinolaryngology Extra)
Wed, 23 Mar 2016 23:00:00 +0100This study examined the risk of adverse maternal and neonatal outcomes, especially cerebral palsy (CP) and intellectual disability (ID) in pregnant women with and without chronic kidney disease (CKD) and their children. (Source: Pediatric Neurology)
Wed, 23 Mar 2016 23:00:00 +0100Simulation based learning is well established in paediatric and neonatal medicine. The Department of Health as well as the RCPCH advocate the use of simulation based learning to enhance clinical performance and patient safety. In this article we describe the establishment of the Welsh Paediatric Simulation Group, its current functional status and future development plans. (Source: Paediatrics and Child Health)
Wed, 23 Mar 2016 23:00:00 +0100CONCLUSION: Preterm surveillance clinic using cervical length and fFN accurately risk triage asymptomatic high-risk pregnant women. Women at highest risk of adverse outcome can be identified for elective admission to hospital and appropriate management. PMID: 27009466 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Wed, 23 Mar 2016 22:13:07 +0100The Texas Children’s Hospital (TCH) Biomedical Engineering Department, in conjunction with the Kangaroo Crew and Nursing departments, strive to increase the quality of patient care through research and innovation. The TCH has been engaged in a comprehensive research campaign to characterize the type of mechanical forces that the neonate would experience in a transport incubator on a typical neonatal transport. After several years of measuring vibration forces during in-hospital (J Clin Eng. 2008:74-77), ambulance, and air transportation modalities, it was determined that our core need was to conduct forced vibration tests of the transport incubator in a simulated environment using a large shaker table (Space Act Agreement no. SAA-EA-09-006 with TCH Biomedical Engineering, TCH contract no...
Wed, 23 Mar 2016 18:41:02 +0100Authors: Agarwal S, Kovilam O, Zach TL, Agrawal DK Abstract Celiac Disease is an autoimmune enteropathy with increasing incidence worldwide in both adults and children. It occurs as an inflammatory condition with destruction of the normal architecture of villi on consumption of gluten and related protein products found in wheat, barley and rye. However, the exact pathogenesis is not yet fully understood. A gluten-free diet remains the main modality of therapy to date. While some patients continue to have symptoms even on a gluten-free diet, adherence to this diet is also difficult, especially for the children. Hence, there is continued interest in novel methods of therapy and the current research focus is on the promising novel non-dietary modalities of treatment. Here, we critical...
Wed, 23 Mar 2016 18:27:00 +0100The Food and Drug Administration (FDA) announced yesterday that it has issued class-wide safety labeling changes for immediate-release (IR) opioid pain medications in an ongoing effort to educate prescribers and patients about the potential risks associated with opioid use. Among the changes, the FDA is requiring a new boxed warning about the serious risks of misuse, abuse, addiction, overdose, and death from IR opioids, which are intended for use every four to six hours.“IRs [opioids] are the most frequently prescribed type of opioid medication,” said Douglas Throckmorton, M.D., deputy director of regulatory programs at the FDA’s Center for Drug Evaluation and Research, during a conference call. Until now, very few IR opioids have received labeled warnings, he explained. (In 2013, t...
Wed, 23 Mar 2016 16:02:20 +0100It was almost a year ago that the American College of Obstetricians and Gynecologists came out unequivocally in favor of universal screening for perinatal depression. In the revised policy... (Source: Pediatric News)
Wed, 23 Mar 2016 14:45:02 +0100In conclusion, the results of the present study demonstrated that treatment with curcumin effectively suppresses TGF-β1-induced CF differentiation via Smad-2 and p38 signaling pathways. Thus, curcumin may be a potential therapeutic agent for the treatment of cardiac fibrosis. PMID: 26998027 [PubMed - as supplied by publisher] (Source: Experimental and Therapeutic Medicine)
Wed, 23 Mar 2016 11:07:26 +0100(Source: Seminars in Perinatology)
Wed, 23 Mar 2016 11:07:26 +0100(Source: Seminars in Perinatology)
Wed, 23 Mar 2016 11:07:26 +0100(Source: Seminars in Perinatology)
Wed, 23 Mar 2016 11:07:26 +0100(Source: Seminars in Perinatology)
Wed, 23 Mar 2016 07:13:38 +0100Estudo quantitativo, descritivo-exploratório, com objetivo de identificar fatores relacionados à segurança do paciente quanto à comunicação no processo de passagem de plantão das equipes de enfermagem. Realizado entre abril e maio de 2012, com 70 profissionais de enfermagem de três unidades de cuidados intensivos neonatais, através de instrumento validado sobre passagem de plantão. Para análise dos dados, utilizaram-se os testes Qui-Quadrado e t-Student. Os resultados demonstraram que os fatores que podem comprometer a segurança do paciente durante a passagem de plantão devido à interrupção e, assim, causando possível perda de importantes informações para a assistência segura, foram atrasos, saídas antecipadas, realização de cuidados e conversas paralelas. Os enferme...
Wed, 23 Mar 2016 04:22:18 +0100Conclusions Although our findings suggest that [25(OH)D] <50 nmol/L is associated with reduced risk of having a LBW infant, prenatal vitamin D recommendations require an examination of the literature that considers the full spectrum of maternal and neonatal outcomes. (Source: Archives of Gynecology and Obstetrics)
Wed, 23 Mar 2016 04:22:18 +0100Conclusion Perineal pudendal injection is an effective and safe technique for anesthesia in diagnostic (vulva biopsy) and therapeutic indications (pudendal neuralgia), and regional anesthesia in perinatal settings. (Source: Archives of Gynecology and Obstetrics)
Tue, 22 Mar 2016 23:00:00 +0100ConclusionsPopulation‐based sampling for subfertility cohort research identifies women who were more likely to have had less intensive treatment or no treatment. However, in both clinic‐based and population‐based sampling, women who have had a live birth are more likely to respond to retrospective recruitment. (Source: Paediatric and Perinatal Epidemiology)
Tue, 22 Mar 2016 23:00:00 +0100Conclusions The data suggest that yacon extract reduces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents (phenolic compounds). (Source: Asian Pacific Journal of Tropical Medicine)
Tue, 22 Mar 2016 23:00:00 +0100Conclusion IFT combinations reinforced the therapeutic effect on osteoporosis by modulating multi-signaling pathways and action targets. Graphical abstract (Source: Journal of Ethnopharmacology)
Tue, 22 Mar 2016 23:00:00 +0100This study demonstrates a case of a huge genital hematoma after delivery, associated with fibrinogen Dorfen. Fibrinogen Dorfen is the mutation of a fibrinogen‐coded exon gene, which has a single heterozygous GCC → GTC transition at codon 289 of the γ gene, predicting an Ala → Val substitution. Because Ala289 plays a crucial role in maintaining the structure of the polymerization site of hole ‘a’ via a hydrogen bond, it is speculated that the γ 289Ala → Val substitution can change not only the fibrinogen structure, but also the function of polymerization. In our case, although the patient's gene mutation was the same as that of her mother, there was a discrepancy in the clinical outcomes. Although the precise mechanism regarding this discrepancy remains unknown, it may cause d...
Tue, 22 Mar 2016 23:00:00 +0100ConclusionThere is a relation between neonatal outcomes in twins and time interval between ACS administration and birth. Therefore, a single ACS course should be administered with caution in order to allow for the completion of the treatment without exceeding an interval of 7 days to delivery. © 2016 Japan Society of Obstetrics and Gynecology (Source: Journal of Obstetrics and Gynaecology Research)
Tue, 22 Mar 2016 23:00:00 +0100Conclusion Most women were able to conceive following CSPs. Reproductive outcomes included normal intrauterine term pregnancy, miscarriage, recurrent CSP, and infertility. Placenta accreta, which could be misdiagnosed antenatally, was a serious complication in subsequent pregnancies. Diverticulum or defect in the lower uterine segment could happen after CSP. Repair of the uterine defect, following a CSP neither guaranteed the healing of the scar, nor the ability to ensure a safe pregnancy outcome. Appropriate counseling to women desiring fertility with a history of CSP is essential and once they conceive early referral to tertiary centers for follow up is pertinent. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Tue, 22 Mar 2016 23:00:00 +0100Conclusions The groups thus had similar results for rates of vaginal delivery within 24h, cesarean delivery and fetal outcomes. The misoprostol group had lower modified Bishop scores, higher BMIs, and a higher rate of fetal scalp blood testing. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Tue, 22 Mar 2016 23:00:00 +0100ConclusionOur study demonstrated that cranial ultrasound can be used effectively in a middle‐income country to identify high‐risk infants and monitor quality of care.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Tue, 22 Mar 2016 23:00:00 +0100ConclusionFindings suggest that mindfulness without meditation can be easily taught and may enhance the pregnancy experience for mother and fetus. (Source: Journal of Clinical Psychology)
Tue, 22 Mar 2016 23:00:00 +0100Respiratory monitoring during mechanical ventilation provides a real-time picture of patient-ventilator interaction and is a prerequisite for lung-protective ventilation. Nowadays, measurements of airflow, tidal volume and applied pressures are standard in neonatal ventilators. The measurement of lung volume during mechanical ventilation by tracer gas washout techniques is still under development. The clinical use of capnography, although well established in adults, has not been embraced by neonatologists because of technical and methodological problems in very small infants. (Source: Paediatric Respiratory Reviews)
Tue, 22 Mar 2016 23:00:00 +0100(Source: American Journal of Medical Genetics Part A)
Tue, 22 Mar 2016 23:00:00 +0100Despite recent progress in the genetic characterization of congenital muscle diseases, the genes responsible for a significant proportion of cases remain unknown. We analysed two branches of a large consanguineous family in which four patients presented with a severe new phenotype, clinically marked by neonatal-onset muscle weakness predominantly involving axial muscles, life-threatening respiratory failure, skin abnormalities and joint hyperlaxity without contractures. Muscle biopsies showed the unreported association of multi-minicores, caps and dystrophic lesions. Genome-wide linkage analysis followed by gene and exome sequencing in patients identified a homozygous nonsense mutation in TRIP4 encoding Activating Signal Cointegrator-1 (ASC-1), a poorly characterized transcription coactiva...
Tue, 22 Mar 2016 23:00:00 +0100Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity. (Source: Clinics in Perinatology)
Tue, 22 Mar 2016 23:00:00 +0100Authors: Nüsken E, Wohlfarth M, Lippach G, Rauh M, Schneider H, Dötsch J, Nüsken KD Abstract Leptin availability in perinatal life critically affects metabolic programming. We tested the hypothesis that utero-placental insufficiency and intrauterine stress affect perinatal leptin availability in rat offspring. Pregnant rats underwent bilateral uterine vessel ligation (LIG, n=14), sham operation (SOP, n=12), or no operation (controls, C, n=14). Fetal livers (n=180), placentas (n=180) and maternal blood were obtained 4h (gestational day E19), 24h (E20) and 72h (E22) after surgery. In the offspring, we took blood samples on E22 (n=44), postnatal day 1 (P1; n=29), P2 (n=16), P7 (n=30) and P12 (n=30). Circulating leptin (ELISA) was significantly reduced in LIG (E22, P1, P2) and SOP o...
Tue, 22 Mar 2016 23:00:00 +0100(Source: American Journal of Clinical Dermatology)
Tue, 22 Mar 2016 23:00:00 +0100CONCLUSIONS: Based on moderate-quality evidence, chlorhexidine dressing/alcohol skin cleansing reduced catheter colonisation, but made no significant difference in major outcomes like sepsis and CRBSI compared to polyurethane dressing/povidone-iodine cleansing. Chlorhexidine dressing/alcohol cleansing posed a substantial risk of contact dermatitis in preterm infants, although it was unclear whether this was contributed mainly by the dressing material or the cleansing agent. While silver-alginate patch appeared safe, evidence is still insufficient for a recommendation in practice. Future research that evaluates antimicrobial dressing should ensure blinding of caregivers and outcome assessors and ensure that all participants receive the same co-interventions, such as the skin cleansing agent...
Tue, 22 Mar 2016 17:10:03 +0100Stephen FellerLUND, Sweden, March 22 (UPI) -- Researchers in Sweden found light can be used to examine the lungs of premature babies without exposing them to radiation, according to a recent study. (Source: Health News - UPI.com)
Tue, 22 Mar 2016 15:18:43 +0100NHS England has published this guidance is designed to support providers, commissioners and professionals take action to reduce stillbirths and early neonatal death. It brings together four elements of care that are recognised as evidence-based and/or best practice: reducing smoking in pregnancy; risk assessment and surveillance for fetal growth restriction; raising awareness of reduced fetal movement; and effective fetal monitoring during labour. (Source: Current Awareness Service for Health (CASH))
Tue, 22 Mar 2016 14:16:01 +0100CONCLUSION: Beyond lower gestational age and mean birthweight, perinatal complications did not increase with fibroids during pregnancy. Performing myomectomy increases the need for transfusion (Grade 2) without an increase in the risk of hysterectomy (Grade 3) and other life-threatening complications (Grade 4-5). Leaving fibroids in situ during C/S did not prevent a fall in post-partum hemoglobin levels. PMID: 26995889 [PubMed - in process] (Source: Journal of Reproductive Medicine)
Tue, 22 Mar 2016 09:25:19 +0100Conclusions were robust after exclusion of studies at high risk of bias. Due to poor reporting of VD24, the cost‐effectiveness analysis compared a subset of 20 interventions. There was considerable uncertainty in estimates, but buccal/sublingual and titrated (low‐dose) misoprostol showed the highest probability of being most cost‐effective. ConclusionsFuture trials should be designed and powered to detect a method that is more cost‐effective than low‐dose titrated oral misoprostol. Tweetable abstractNew study ranks methods to induce labour in pregnant women on effectiveness and cost. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Tue, 22 Mar 2016 07:43:43 +0100We present the case of a newborn patient with neonatal cyanosis, who was diagnosed with F-M-Osaka methemoglobinemia, and an up-to-date literature review of the disease. (Source: Journal of Pediatric Hematology Oncology)
Tue, 22 Mar 2016 07:43:43 +0100Conclusion: Growth-restricted preterm newborns are at risk for poor iron endowment, likely due to uteroplacental insufficiency. Other RFs were less impactful on iron status of premature newborns than in term newborns, likely reflecting that disruptive effects of RFs are more impactful in the third trimester. Understanding RFs for poor iron endowment is important for clinical recognition and treatment of premature babies. (Source: Journal of Pediatric Hematology Oncology)
Tue, 22 Mar 2016 07:43:43 +0100Although a leukemoid reaction is a well-recognized phenomenon in the neonatal intensive care unit, transient extreme hyperleukocytosis in premature infants is rare. The exact mechanism is still unclear and several hypotheses are documented in the literature. In this case report, we describe 2 dichorionic diamniotic premature twins, of whom the 2 girls had extreme hyperleukocytosis, whereas their siblings did not, emphasizing the potentially important role of the sex in this phenomena. (Source: Journal of Pediatric Hematology Oncology)
Tue, 22 Mar 2016 06:34:12 +0100Recent work has focused on characterizing immune tolerance to commensal microbiota in the gastrointestinal tract; however, the cellular and molecular mechanisms that mediate immune homeostasis in the skin have yet to be elucidated. Scharschmidt and colleagues utilized a model system to track antigen-specific immune responses to an engineered skin commensal bacteria. In this model, neonatal colonization was required for establishing tolerance to skin commensal bacteria, and in fact, bacterial colonization during adult life did not invoke tolerance. (Source: Journal of Investigative Dermatology)
Tue, 22 Mar 2016 00:00:00 +0100Nasha K. Nensey, Jonathan Bodager, Ashley L. Gehrand, Hershel Raff (Source: Frontiers in Endocrinology)
Tue, 22 Mar 2016 00:00:00 +0100Conclusion By comparison with women without childbirth complications, SMM impaired self-reported functioning among women 1–5years after delivery. (Source: International Journal of Gynecology and Obstetrics)
Tue, 22 Mar 2016 00:00:00 +0100Neonatal astrocytes are diverse in origin, and undergo dramatic change in gene expression, morphological differentiation and syncytial networking throughout development. Neonatal astrocytes also play multifac... (Source: Molecular Brain)
Tue, 22 Mar 2016 00:00:00 +0100Metabolic syndrome (MetS) is a cluster of risk factors for type 2 diabetes (Type2 DM) and cardiovascular diseases (CVD), and its prevalence varies based on region, population, and sex. Newborns of women with M... (Source: Diabetology and Metabolic Syndrome)
Tue, 22 Mar 2016 00:00:00 +0100Breastfeeding is associated with a variety of positive health outcomes in children and is recommended exclusively for the first 6 months of life; however, 50–70 % of infants in the US are formula-fed. To test ... (Source: BMC Gastroenterology)
Tue, 22 Mar 2016 00:00:00 +0100Birth defects are a leading cause of neonatal and infant mortality, and several studies have indicated an increase in the prevalence of birth defects; more recent investigations have suggested that the trends ... (Source: BMC Pregnancy and Childbirth)
Tue, 22 Mar 2016 00:00:00 +0100Perinatal depression among HIV-positive women has negative implications for HIV-related and other maternal and infant outcomes. The aim of this study was to investigate the burden and correlates of perinatal d... (Source: Reproductive Health)
Mon, 21 Mar 2016 23:00:00 +0100In this study we empirically tested 3 largely unverified hypotheses about the impact of neonatal circumcision on adult penile sensitivity, knowing that a single study will not resolve the circumcision debate. However, it is our hope that this research can begin to pave the way for additional work in the area of sexual correlates of circumcision. Specifically we hope to initiate a shift toward more empirically rigorous research exploring the impact of neonatal circumcision on the sexual lives of men. (Source: The Journal of Urology)
Mon, 21 Mar 2016 23:00:00 +0100The recent identification of the benefit of circumcision in the prevention of HIV led the American Academy of Pediatrics to revise its recommendations. Concerns continue to be raised about the potential impact in changing sensation of the penis after circumcision. Bossio et al address this concern with objective evaluation of penile sensation in men who underwent neonatal circumcision compared to uncircumcised men. They were unable to demonstrate differences in any of the tested parameters. In addition, they did not note any difference in sexual dysfunction in the tested cohorts. (Source: The Journal of Urology)
Mon, 21 Mar 2016 23:00:00 +0100The objective of the workshop was to bring together experts in SCD from around the world to contribute their expertise to the development of various aspects of the SCD ontology. (Source: Applied and Translational Genomics)
Mon, 21 Mar 2016 23:00:00 +0100The health performance of Gujarat viewed in terms of the Human Development Index (HDI) portrays it as a medium performer in the country. However, the index of health component for Gujarat is found to be positively contributing to the HDI ranking of the state. It is, therefore, crucial to review the status of health performance of Gujarat among the other states for improving its relative standing in human development. In this context, the present article attempts to identify the gaps in performance of the health-related outcome, output and input indicators from the best performers in each indicator. Moreover, the article also reviews the trends in health performance of Gujarat over time and also estimates the effectiveness of the state in converting its health inputs to outputs and outputs ...
Mon, 21 Mar 2016 23:00:00 +0100This study was designed to unravel the interactions of recombinant dog gastric lipase (rDGL) with model monolayers presenting liquid–liquid phase coexistence and mimicking the outer leaflet of the milk fat globule membrane. Combining biophysical tools (ellipsometry, tensiometry and atomic force microscopy), it was evidenced that rDGL partitions toward liquid expanded phase and at phase boundaries. rDGL gets adsorbed at several levels of insertion suggesting molecular cooperation that may favor insertion and strongly impacts on the lipid phase lateral organization. The addition of phosphatidylserine, negatively charged, reinforced adsorption; hence besides hydrophobic interactions and as further investigated through surface potential modeling, rDGL adsorption is favored by electrostatic i...
Mon, 21 Mar 2016 23:00:00 +0100ConclusionThese results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Mon, 21 Mar 2016 23:00:00 +0100Publication date: May 2016 Source:Veterinary Immunology and Immunopathology, Volume 173 Author(s): Sanjay Sarkar, Udeni B.R. Balasuriya, David W. Horohov, Thomas M. Chambers Equine herpesvirus-1 (EHV-1) is a major respiratory viral pathogen of horses, causing upper respiratory tract disease, abortion, neonatal death, and neurological disease that may lead to paralysis and death. EHV-1 replicates initially in the respiratory epithelium and then spreads systemically to endothelial cells lining the small blood vessels in the uterus and spinal cord leading to abortion and EHM in horses. Like other herpesviruses, EHV-1 employs a variety of mechanisms for immune evasion including suppression of type-I interferon (IFN) production in equine endothelial cells (EECs). Previously we have shown ...
Mon, 21 Mar 2016 23:00:00 +0100CONCLUSIONS At present, no environmental risk factors have convincingly been associated with OCD. We propose a roadmap for future studies, consisting of longitudinal, population-based research, employing quasi-experimental family and twin designs to identify risk factors that are not only associated with the disorder but also contribute to its causation either directly or moderating the effect of genes. (Source: Neuroscience and Biobehavioral Reviews)
Mon, 21 Mar 2016 23:00:00 +0100Conclusion Our experience with fetal and neonatal EA/TVD shows better survival rates than previously reported. Mortality after a fetal diagnosis was significantly associated with haemodynamic changes indicative of a circular shunt, including pulmonary and tricuspid regurgitation severe enough to cause diastolic umbilical arterial flow reversal. Teaser This contemporary experience with 79 fetuses and neonates diagnosed with Ebsteins’ anomaly or dysplasia of the tricuspid valve shows improvements in the prenatal anomaly detection and overall survival rates when compared to previous studies. Mortality following a fetal diagnosis was significantly associated with the failure of the right ventricle to generate near-normal peak systolic pressures to birth and the prenatal emergence of a circul...
Mon, 21 Mar 2016 23:00:00 +0100Publication date: Available online 22 March 2016 Source:Pharmacology & Therapeutics Author(s): João Pedro Martins, Patrick J. Kennedy, Hélder A. Santos, Cristina Barrias, Bruno Sarmento Advances in the understanding of neonatal Fc receptor (FcRn) biology and function have demonstrated that this receptor, primarily identified for the transfer of passive immunity from mother infant, is involved in several biological and immunological processes. In fact, FcRn is responsible for the long half-life of IgG and albumin in the serum, by creating an intracellular protein reservoir, which is protected from lysosomal degradation and, importantly, trafficked across the cell. Such discovery has led researchers to hypothesize the role for this unique receptor in the controlled delivery ...
Mon, 21 Mar 2016 23:00:00 +0100Conclusions. These findings illustrate that a significant number of women giving birth in Philadelphia test positive for HCV and that most of their at-risk children remain untested. To successfully identify all HCV-infected children and integrate them into HCV-specific care, practices for HCV screening of pregnant women and their children should be improved. (Source: Clinical Infectious Diseases)
Mon, 21 Mar 2016 23:00:00 +0100Conclusions. CD4+RTE% predicts disease progression and may reflect history of disease in HIV-positive patients and adolescents. They are easy to measure in the clinical setting and may be helpful markers in guiding treatment decisions. (Source: Clinical Infectious Diseases)
Mon, 21 Mar 2016 23:00:00 +0100WHO Director-General, Dr Margaret Chan, updates the public on Zika virus and the observed increase in neurological disorders and neonatal malformations. WHO expert meetings have identified gaps in knowledge about Zika virus, potentially related complications, effective interventions, and areas of needed research and technologies. Dr Chan highlights findings and next steps in the fight against Zika. (Source: WHO news on Zika virus)
Mon, 21 Mar 2016 23:00:00 +0100A commonly used but poorly measured term in neonatal healthcare is “value.” Value defines the relationship between outcome and cost of care, both of which are difficult to measure in neonatal medicine.1 Truly understanding the outcome and the cost of achieving that outcome in a neonate requires years of follow-up. Nonetheless, defining and measuring value is important. It focuses efforts to improve health care,2 and serves as the underlying basis for the Institute for Healthcare Improvement concept of “The Triple Aim,” which urges better care and satisfaction for the individual and family, while improving population health, at lower cost. (Source: The Journal of Pediatrics)
Mon, 21 Mar 2016 23:00:00 +0100Conclusion The area under ROC curve (AUC) of TNF and CRP in the diagnosis of sepsis was superior to determinations of IL-1 and IL-6. From our data analysis and based on our financial backgrounds, we can conclude that abnormal of CRP levels together with immature-to-total neutrophil ratio above 0.2 with or without elevated IL-1, IL-6 or TNF can be used as early markers of sepsis in neonates. (Source: Egyptian Pediatric Association Gazette)
Mon, 21 Mar 2016 23:00:00 +0100While antidepressant medications are currently used during conception, gestation and post-partum, considerable uncertainty exists regarding the benefits and harms conferred to mothers and their offspring. A significant body of evidence has focused on antidepressant use during pregnancy and post-partum. However, it is difficult to know if this translates to specific populations. Women receiving treatment for infertility are especially vulnerable to symptoms of depression and adverse perinatal outcomes. (Source: Journal of Psychosomatic Research)
Mon, 21 Mar 2016 23:00:00 +0100Conclusions PreE alters the intrauterine environment and activates the detrimental signaling that is transported to fetus resulting in premature deliveries, IUGR babies and their related complications like extended hospitalization. (Source: Journal of Investigative Medicine)