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MedWorm: Pediatrics



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Pediatrics



Last Build Date: Mon, 28 Mar 2016 00:26:02 +0100

 



Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets.

Sun, 27 Mar 2016 00:22:02 +0100

Authors: Porrello A, Piergentili RB Abstract Research on bladder neoplasms in pediatric and teen patients (BNPTP) has described 21 genes, which are variously involved in this disease and are mostly responsible for deregulated cell proliferation. However, due to the limited number of publications on this subject, it is still unclear what type of relationships there are among these genes and which are the chances that, while having different molecular functions, they i) act as downstream effector genes of well-known pro- or anti- proliferative stimuli and/or interplay with biochemical pathways having oncological relevance or ii) are specific and, possibly, early biomarkers of these pathologies. A Gene Ontology (GO)-based analysis showed that these 21 genes are involved in biological ...

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Genetics of Bladder Malignant Tumors in Childhood.

Sun, 27 Mar 2016 00:22:02 +0100

Authors: Zangari A, Zaini J, Gulìa C Abstract Bladder masses are represented by either benign or malignant entities. Malignant bladder tumors are frequent causes of disease and death in western countries. However, in children they are less common. Additionally, different features are found in childhood, in which non epithelial tumors are more common than epithelial ones. Rhabdomyosarcoma is the most common pediatric bladder tumor, but many other types of lesions may be found, such as malignant rhabdoid tumor (MRT), inflammatory myofibroblastic tumor and neuroblastoma. Other rarer tumors described in literature include urothelial carcinoma and other epithelial neoplasms. Rhabdomyosarcoma is associated to a variety of genetic syndromes and many genes are involved in tumor developmen...



Bladder Conditions in Pediatric Patients: Genetics and Genomics.

Sun, 27 Mar 2016 00:22:02 +0100

Authors: Piergentili R PMID: 27013920 [PubMed] (Source: Current Genomics)



Resection of Bilateral Bronchopulmonary Sequestrations via a Single Left-Sided Muscle-Sparing Thoracotomy

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): Scott Deeney, Matthew Landman, Timothy M. Crombleholme (Source: Journal of Pediatric Surgery Case Reports)



Pets Help Homeless Youth, Study Finds

Sat, 26 Mar 2016 23:00:00 +0100

They're less likely to engage in harmful behaviors, but many shelters won't accept animals (Source: The Doctors Lounge - Psychiatry)



Diagnosis and management of mesiodens based on the investigation of its position using cone-beam computed tomography

Sat, 26 Mar 2016 23:00:00 +0100

Conclusion Our results will be helpful when deciding on the timing of mesioden extraction with minimum stress and risk for children. (Source: Pediatric Dental Journal)

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Fixed dose combination of Anti-tubercular drugs: Time to reformulate

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Pediatric Infectious Disease Author(s): Sumit Mehndiratta (Source: Pediatric Infectious Disease)



Disseminated Bacille Calmette-Guérin Disease in an Infant with a Novel bi-allelic Mutation in Interferon Gamma Receptor-1 Gene

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Pediatric Infectious Disease Author(s): C.K. Indumathi, Bijayanti Mishra, A.S. Caroline Deswarte, Jacinta Bustamante (Source: Pediatric Infectious Disease)



Orbital entomophthoromycosis in a toddler–an unusual presentation/a case report

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Pediatric Infectious Disease Author(s): Mourouguessine Vimal, Marie Therese Manipadam, Soosan Jacob Entomophthoromycosis is a rare fungal infection seldom occurring in humans. Only very few cases of Entomophthoromycosis exclusively involving the orbit have been reported in the literature. We are reporting a case of Entomophthoromycosis in a toddler who presented with swelling of the left orbit following trauma to the left eye. The nonspecific clinical signs and symptoms of the patient posed us diagnostic dilemma. Histopathological examination helped us to arrive at the correct diagnosis and proper management of the patient. A high index of suspicion in required in these patients for timely diagnosis and treatment which would impr...

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Unusual presentation of enteric fever in 11 year old female child

Sat, 26 Mar 2016 23:00:00 +0100

We report a case of enteric fever which presented to start with as acute gastritis and then went on to develop acute pancreatitis which is a rare complication of enteric fever; along with capillary leak syndrome in the acute phase mimicking dengue shock syndrome. This unusual presentation has not been reported in Indian or foreign literature. (Source: Pediatric Infectious Disease)



Crystal Induced Nephrotoxicity Associated with Acyclovir Use in Paediatric Patient

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Pediatric Infectious Disease Author(s): Abin Chandrakumar, Pretty G Tharakan, Bittu Thomas, Anu Albert, Teena Jacob Drug induced nephrotoxicity has evolved as one of the significant causes of renal failure in the contemporary setting accounting up to 20%. Acyclovir is an antiviral agent which has potential for precipitating transient crystal induced nephrotoxicity especially in elderly, euvolemic or renal patients when given as rapid intravenous bolus. The current case depicts evolution and management of transient nephropathy in a paediatric patient treated with Acyclovir for viral encephalopathy. The case presents a contrasting scenario to the conventional milieu of risk factors and surmise the possibility of genetic factor pr...



Cytomegalovirus Infection in Children after Bone Marrow Transplantation: Risk factors, Clinical aspects and Outcomes

Sat, 26 Mar 2016 23:00:00 +0100

Conclusions Antigenemia-guided pre-emptive strategy with ganciclovir was very affective and CMV reactivation tended not to affect the outcome in our study cohort. (Source: Pediatric Infectious Disease)



Rotavirus infection markers in children with rotaviral gastroenteritis and their relation to disease severity

Sat, 26 Mar 2016 23:00:00 +0100

Conclusion Accordingly, we can conclude that rotaviral antigenemia and viremia were common in children with rotaviral diarrhea, however, the impact of rotavirus antigenemia/viremia on clinical manifestations of infection is unknown. (Source: Pediatric Infectious Disease)



Lab diagnosis of brucellosis

Sat, 26 Mar 2016 23:00:00 +0100

This article reviews the various culture methods, serological tests and newer diagnostic methods available in making a laboratory diagnosis of brucellosis along with their advantages and drawbacks. (Source: Pediatric Infectious Disease)

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Medication adherence and the use of new pharmaceutical formulations: the case of levothyroxine.

Sat, 26 Mar 2016 11:41:02 +0100

CONCLUSIONS: All the characteristics of new levothyroxine oral liquid formulations allow to administer the drug also in patients with gastrointestinal comorbidities or patients who are already treated with other drugs. The availability of different dosages let the clinician to adapt the treatment for each individual patient. These benefits contribute to a better medication adherence and to the maintenance of normal TSH levels. In conclusion, the use of different pharmaceutical formulations represents a therapeutic approach innovative, effective and inexpensive in the treatment of the hypothyroid patient. PMID: 27015567 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)



A study of fatal and non-fatal paediatric poisoning cases in Bangalore, India - Satish KV, Shivakumar P, Anand M.

Sat, 26 Mar 2016 11:13:34 +0100

Study fatal and non-fatal paediatric poisoning cases was conducted in Department of Forensic Medicine and Toxicology in Victoria Hospital collaboration with the Department of Pediatrics, Vani Vilas Hospital and, attached to Bangalore Medical College and Re... (Source: SafetyLit)



Profile of acute paediatric poisoning cases admitted in a tertiary care centre in North India - Aziz UBA, Aslami AN, Ali SM.

Sat, 26 Mar 2016 11:13:34 +0100

The present study was carried out to determine the profile and outcome of acute paediatric poisoning presented in paediatrics emergency department of Jawaharlal Nehru Medical College, AMU, Aligarh. A retrospective study was carried out on 102 cases of acut... (Source: SafetyLit)



Journey of Excellence: Implementing a Shared Decision-Making Model.

Sat, 26 Mar 2016 06:14:02 +0100

Authors: Murray K, Yasso S, Schomburg R, Terhune M, Beidelschies M, Bowers D, Goodyear-Bruch C Abstract : Research has shown that nurses who participate in shared decision making (SDM) have more control over their practice and greater job satisfaction, and hospitals that have instituted SDM have lower rates of nurse turnover and better patient outcomes. The purpose of this article is to describe the implementation of an SDM structure at a pediatric hospital. The hospital's chief nurse officer charged a group of nurses with developing SDM guidelines to outline the purpose, structure, and function of unit councils. A targeted, multifaceted approach to the implementation of these guidelines led to the successful standardization of nine existing unit councils and the expansion of the S...

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3 CE Test Hours: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment.

Sat, 26 Mar 2016 06:14:02 +0100

Authors: Contrada E PMID: 27011135 [PubMed - in process] (Source: The American Journal of Nursing)






Autism and chromosome abnormalities – A Review

Sat, 26 Mar 2016 01:25:04 +0100

This article is protected by copyright. All rights reserved. (Source: Clinical Anatomy)



Meconium Peritonitis Following Intestinal Atresia: A Case Report

Fri, 25 Mar 2016 23:00:00 +0100

We present a case of meconium peritonitis with emergent cesarean section delivery after the patient developed massive meconium ascites, hydrops fetalis, and non-reassuring fetal monitoring. In the immediate postnatal period, the patient was intubated and a peritoneal drain was placed for respiratory and hemodynamic stabilization. He was then taken to the operating room the following day for laparotomy and bowel resection. His post-operative course was uneventful, and he was discharged home in good clinical condition. (Source: Journal of Pediatric Surgery Case Reports)



Esophagogastric Fistula Complicating Nissen Fundoplication

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): Marcel Tafen, Nader Tehrani, Afshin A. Anoushiravani, Avinash Bhakta, Timothy G. Canty, Christine Whyte Esophagogastric fistula or double-lumen esophagus is a rare condition. There have been fewer than 15 reported cases in adults and only one reported case in the pediatric population. Esophagogastric fistulas typically develop in patients with preexisting gastrointestinal reflux, esophagogastric surgery, esophageal ulcers, or carcinoma. Our case involves a 5 year-old girl presenting with odynophagia and nocturnal cough who had a prior Nissen fundoplication. She was found to have an esophagogastric fistula. Conservative management with esophageal dilatation and proton pump in...

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Congenital prepubic sinus: a case report and review of the literature

Fri, 25 Mar 2016 23:00:00 +0100

We report a case of CPS and review the literature to improve the global understanding of CPS. (Source: Journal of Pediatric Surgery Case Reports)



Beware of the persistent abscess:Chronic granulomatous disease presenting with suppurative lymphadenitis

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): C. Pardy, J. Pumphrey, R. Hallows, V. Scott, K. Fidler (Source: Journal of Pediatric Surgery Case Reports)



Pediatric scrub typhus in Southern Kerala: An emerging public health problem

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion Scrub typhus is a common cause of fever in South India. Awareness among medical professional should be a high priority as late detection is the cause of failure of treatment, complications, and even mortality. (Source: Clinical Epidemiology and Global Health)



Tuberculous meningitis: symptoms, diagnosis and evaluation experienced in 532 patients in a pediatric hospital

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions TM has continued to be a serious health problem in developing countries. Delay in diagnosis of this disease is a cause of the increase not only of its morbidity but also its mortality as well as its sequels. (Source: Asian Pacific Journal of Tropical Disease)



Basic airway equipments in pediatric cardiac arrest management

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Trends in Anaesthesia and Critical Care Author(s): Kemal Tolga Saracoglu, Ayten Saracoglu, Haluk Kafali In both in-hospital and out-of-hospital settings, pediatric cardiac arrest cases are common. Performing rescue breathing within a shorter time and achieving safe airway as early as possible during resuscitation is important for reducing interruptions. After a thorough review of the literature we concluded that the number of available randomized clinical studies is not enough to prove the superiority of different airway equipments in pediatric cardiac arrests. It is clear that the steps to be taken in this field will help determine the superior methods and create a tremendous impression. There is no data supporting the routine u...

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Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Consistent with results for PBTs in the general population, these results suggest that higher birth weights increase OPG risk in individuals with NF1. (Source: Cancer Epidemiology)



Facial surface morphology predicts variation in internal skeletal shape

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Surface morphology is a reliable source of proxy data for the characterization of skeletal shape variation and thus is particularly valuable in research designs where reducing potential long-term risks associated with radiologic imaging methods is warranted. We propose that longitudinal surface morphology from early childhood through late adolescence can be a valuable source of data that will facilitate the development of personalized craniodental and treatment plans and reduce exposure levels to as low as reasonably achievable. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



The Biology of Stature

Fri, 25 Mar 2016 23:00:00 +0100

Most pediatricians are attuned to their patients' linear growth (height gain). At each visit, the child's height should be carefully measured and plotted. The clinician can then scrutinize the temporal pattern, and, if the linear growth appears abnormal, initiate an investigation to uncover the underlying problem. Despite this close interest in our patients' statural gains, linear growth itself often is considered as a “black box,” a mysterious process regulated by nutrition, hormones, genetics, and overall health. (Source: The Journal of Pediatrics)



Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve?

Fri, 25 Mar 2016 23:00:00 +0100

Supporting the respiratory status of the newly born, critically ill premature neonate is a long held focus of the practicing neonatologist. One could argue that neonatology evolved out of the search for the pathophysiology of respiratory distress syndrome (RDS); and that it was defined by interventions aimed at preventing and treating RDS, namely antenatal corticosteroids (ACS) and surfactant treatment. There are now multiple interventions to assist the premature infant during this transition including ACS, surfactant, monitored administration of supplemental oxygen, and sophisticated mechanical ventilators. (Source: The Journal of Pediatrics)

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Early care of the preterm infant – current evidence

Fri, 25 Mar 2016 23:00:00 +0100

This article gives an overview of the key considerations to be incorporated in to this period, and reviews the latest evidence base behind recommendations including thermoregulatory support, delayed cord clamping, oxygen supplementation, PEEP versus intubation, and the role of surfactant. (Source: Paediatrics and Child Health)



Association between facility type during pediatric inpatient rehabilitation and functional outcomes

Fri, 25 Mar 2016 23:00:00 +0100

To compare functional outcomes between children receiving inpatient rehabilitation at children’s hospitals versus other facilities. (Source: Archives of Physical Medicine and Rehabilitation)



Dermatologic Concerns of the Lower Extremity in the Pediatric Patient

Fri, 25 Mar 2016 23:00:00 +0100

This article covers the most common skin conditions seen on the lower extremity in the pediatric population. (Source: Clinics in Podiatric Medicine and Surgery)

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Dads Invent Simple Device To Prevent Hot Car Fatalities

Fri, 25 Mar 2016 20:24:59 +0100

As we head into warm-weather seasons, parents are reminded of the tragedies that occur each year when small children are accidentally left in hot cars. Two dads from Tampa, Florida have developed a product which they say will prevent hot car fatalities and give parents peace of mind. It's called Sense-A-Life -- an easy-to-use device that alerts parents if they've left their children in the car. Neighbors Jim Friedman, an electrical engineer, and Fadi Shamma, a pharmacist, came up with the idea for Sense-A-Life one day while their children were playing together. Shamma told The Huffington Post that Friedman was talking about some of the engineering side projects he likes to do outside of work. During the same conversation, the parents discussed the many stories they'd read about childr...



Relative Abundance in Bacterial and Fungal Gut Microbes in Obese Children: A Case Control Study.

Fri, 25 Mar 2016 19:29:01 +0100

CONCLUSION: Taking into account the complexity of obesity, our data suggest that differences in relative abundance of some core microbial species, preexisting or diet driven, could actively be part of its etiology. This study improved our knowledge about the fungal population in the pediatric school-age population and highlighted the need to consider the influence of cross-kingdom relationships. PMID: 27007700 [PubMed - as supplied by publisher] (Source: Childhood Obesity)



Think Your Kid Has a Sleeping Problem? Look in the MirrorThink Your Kid Has a Sleeping Problem? Look in the Mirror

Fri, 25 Mar 2016 19:05:01 +0100

Parents who don't get enough rest are more likely to conjure sleep difficulties for their children that don't really exist, a new study suggests. Reuters Health Information (Source: Medscape Medical News Headlines)



Impact of occupational, physical, and speech and language therapy in preschoolers with hyperactive/inattentive symptoms: A naturalistic 2-year follow-up study.

Fri, 25 Mar 2016 18:19:02 +0100

DISCUSSION: The apparent lack of benefit suggests the need for further investigation into efficacy of these treatments in hyperactive/inattentive preschool children. PMID: 27011416 [PubMed - as supplied by publisher] (Source: Children's Health Care)

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TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Amin AD, Li L, Rajan SS, Gokhale V, Groysman MJ, Pongtornpipat P, Tapia EO, Wang M, Schatz JH Abstract The anaplastic lymphoma kinase (ALK) protein drives tumorigenesis in subsets of several tumors through chromosomal rearrangements that express and activate its C-terminal kinase domain. In addition, germline predisposition alleles and acquired mutations are found in the full-length protein in the pediatric tumor neuroblastoma. ALK-specific tyrosine kinase inhibitors (TKIs) have become important new drugs for ALK-driven lung cancer, but acquired resistance via multiple mechanisms including kinase-domain mutations eventually develops, limiting median progression-free survival to less than a year. Here we assess the impact of several kinase-domain mutations that arose during...



Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents.

Fri, 25 Mar 2016 16:53:02 +0100

Authors: Harris RA, Shah R, Hollister EB, Tronstad RR, Hovdenak N, Szigeti R, Versalovic J, Kellermayer R Abstract Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC...



Cannabinoids for seizures: Frankness, comfort, and follow-up are key to gathering data

Fri, 25 Mar 2016 16:34:14 +0100

Since Colorado is “ground zero” for medical marijuana use, the rest of the nation can learn from how pediatric neurologists there are taking care of children with seizures who use cannabinoids.



A neonate with recurrent tetany: questions

Fri, 25 Mar 2016 16:22:21 +0100

(Source: Pediatric Nephrology)

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Chronic haemodialysis in small children: a retrospective study of the Italian Pediatric Dialysis Registry

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Extracorporeal dialysis is feasible in children aged  <2 years, but comorbidities, vascular access, growth and anaemia remain major concerns. (Source: Pediatric Nephrology)



Smaller circuits for smaller patients: improving renal support therapy with Aquadex™

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions CRRT machines with low ECV can enable clinicians to provide adequate, timely, safe, and efficient renal support to small, critically ill infants. (Source: Pediatric Nephrology)



Physical activity and screen time in adolescents in the chronic kidney disease in children (CKiD) cohort

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Adolescents with CKD engage in significantly less PA and greater screen time than healthy youth in the United States, and this may worsen over time. (Source: Pediatric Nephrology)



HNF1B-associated clinical phenotypes: the kidney and beyond

Fri, 25 Mar 2016 16:22:21 +0100

Abstract Mutations in HNF1B, the gene encoding hepatocyte nuclear factor 1β are the most commonly identified genetic cause of renal malformations. HNF1B was first identified as a disease gene for diabetes (MODY5) in 1997, and its involvement in renal disease was subsequently noted through clinical observations in pedigrees affected by MODY5. Since then, a whole spectrum of associated phenotypes have been reported, including genital malformations, autism, epilepsy, gout, hypomagnesaemia, primary hyperparathyroidism, liver and intestinal abnormalities and a rare form of kidney cancer. The most commonly identified mutation, in approximately 50 % of patients, is an entire gene deletion occurring in the context of a 17q12 chromosomal microdeletion that also includes several other ge...



Renal abnormalities in a cohort of HIV-infected children and adolescents

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART. (Source: Pediatric Nephrology)

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Cinacalcet as adjunctive therapy in pseudohypoparathyroidism type 1b

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Due to its ease of administration, we recommend the addition of cinacalcet into the armamentarium of medications available to treat children with PHP1b. (Source: Pediatric Nephrology)



Evolution of IgA nephropathy into anaphylactoid purpura in six cases—further evidence that IgA nephropathy and Henoch–Schonlein purpura nephritis share common pathogenesis

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Our clinical experience and previous reports support the argument that IgA nephropathy and HSPN are different manifestations of a single disease. Hence, it is acceptable to consider that they are variants of a single disease. (Source: Pediatric Nephrology)



A neonate with recurrent tetany: Answers

Fri, 25 Mar 2016 16:22:21 +0100

(Source: Pediatric Nephrology)



Vitamin K antagonists in children with central venous catheter on chronic haemodialysis: a pilot study

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Therapy with VKA would appear to be safe in children on chronic HD and may improve CVC survival in patients at increased risk of CVC thrombosis. (Source: Pediatric Nephrology)



Hyperfiltration and uricosuria in adolescents with type 1 diabetes

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions The adolescents with T1D enrolled in the study had higher eGFR, higher UUA and more acidic urine than the non-diabetic controls, which may have increased their risk of UUA crystallization. Adolescents with T1D and hyperfiltration had higher FeUA than those without hyperfiltration. These hypothesis-generating observations may suggest a potential pathophysiologic association between uricosuria and hyperfiltration. (Source: Pediatric Nephrology)

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Acute changes in fluid status affect the incidence, associative clinical outcomes, and urine biomarker performance in premature infants with acute kidney injury

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Adjusting SCr for acute change in fluid weight may help differentiate SCr rise from true change in renal function from acute concentration due to abrupt weight change. (Source: Pediatric Nephrology)



Microalbuminuria among HIV-infected antiretroviral therapy-naive children in the Democratic Republic of Congo

Fri, 25 Mar 2016 16:22:21 +0100

Conclusion The prevalence of microalbuminuria was 18% in the HIV-infected children and 2% in the HIV-uninfected children. No common determinants of proteinuria were significantly associated with microalbuminuria. (Source: Pediatric Nephrology)



Comparison of reticulocyte hemoglobin equivalent with traditional markers of iron and erythropoiesis in pediatric dialysis

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Ret-He is a more relevant marker of iron status than ferritin and TSAT. This supports prospectively testing Ret-He to distinguish between iron deficiency and suboptimal erythropoietin dosing as competing causes for anemia. Ferritin is an unhelpful biomarker of iron deficiency in this setting. (Source: Pediatric Nephrology)



Renal transplantation in infants

Fri, 25 Mar 2016 16:22:21 +0100

Abstract Renal transplantation (RTx) has become an accepted mode of therapy in infants with severe renal failure. The major indications are structural abnormalities of the urinary tract, congenital nephrotic syndrome, polycystic diseases, and neonatal kidney injury. Assessment of these infants needs expertise and time as well as active treatment before RTx to ensure optimal growth and development, and to avoid complications that could lead to permanent neurological defects. RTx can be performed already in infants weighing around 5 kg, but most operations occur in infants with a weight of 10 kg or more. Perioperative management focuses on adequate perfusion of the allograft and avoidance of thrombotic and other surgical complications. Important long-term issues include rejection...



Tubular atrophy in the pathogenesis of chronic kidney disease progression

Fri, 25 Mar 2016 16:22:21 +0100

Abstract The longstanding focus in chronic kidney disease (CKD) research has been on the glomerulus, which is sensible because this is where glomerular filtration occurs, and a large proportion of progressive CKD is associated with significant glomerular pathology. However, it has been known for decades that tubular atrophy is also a hallmark of CKD and that it is superior to glomerular pathology as a predictor of glomerular filtration rate decline in CKD. Nevertheless, there are vastly fewer studies that investigate the causes of tubular atrophy, and fewer still that identify potential therapeutic targets. The purpose of this review is to discuss plausible mechanisms of tubular atrophy, including tubular epithelial cell apoptosis, cell senescence, peritubular capillary rarefacti...

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Remedial operations for failed endovascular therapy of 32 renal artery stenoses in 24 children

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Renal PTA for the treatment of pediatric RVH due to ostial disease may be complicated by failures requiring complex remedial operations or nephrectomy, the latter usually affecting younger children. (Source: Pediatric Nephrology)



Liver transplantation for aHUS: still needed in the eculizumab era?

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions Liver transplant may definitely cure aHUS and represents an option for patients with suboptimal response to eculizumab. (Source: Pediatric Nephrology)



Troubled Kids’ Psychiatric Care Often Delayed by Insurance Rules

Fri, 25 Mar 2016 14:00:00 +0100

Dealing with red tape consumes clinicians' time, poses danger to patients, researchers say (Source: The Doctors Lounge - Psychiatry)



The Future of Myopia Control Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

ABSTRACT: The growing incidence of pediatric myopia worldwide has generated strong scientific interest in understanding factors leading to myopia development and progression. Although contact lenses (CLs) are prescribed primarily for refractive correction, there is burgeoning use of particular modalities for slowing progression of myopia following reported success in the literature. Standard soft and rigid CLs have been shown to have minimal or no effect for myopia control. Overall, orthokeratology and soft multifocal CLs have shown the most consistent performance for myopia control with the least side effects. However, their acceptance in both clinical and academic spheres is influenced by data limitations, required off-label usage, and a lack of clear understanding of their mechanisms fo...



Atropine and Roscovitine Release from Model Silicone Hydrogels

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: Silicone hydrogel materials have the potential to deliver drugs for over 2 weeks without compromising lens properties. This could potentially overcome the need for regular drop instillation and allow for the maintenance of drug concentration in the tear film over the period of wear. This represents a potential option for treating a host of ophthalmic disorders in children including myopia and retinoblastoma. (Source: Optometry and Vision Science)

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CE: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment

Fri, 25 Mar 2016 12:44:16 +0100

The American Cancer Society estimates that in 2014 nearly 16,000 U.S. children and adolescents developed cancer, and in roughly 1,200 of these cases the cancer was Hodgkin lymphoma (HL). The great majority of these patients will survive, joining the thousands who have been diagnosed and treated successfully in decades past. Nurses’ familiarity with and attention to the late effects of the chemotherapy and radiation therapy used to treat HL, which include breast cancer as well as cardiotoxicity and its sequelae, are essential in helping these patients maintain their overall health. (Source: AJN)






Journey of Excellence: Implementing a Shared Decision-Making Model

Fri, 25 Mar 2016 12:44:16 +0100

Research has shown that nurses who participate in shared decision making (SDM) have more control over their practice and greater job satisfaction, and hospitals that have instituted SDM have lower rates of nurse turnover and better patient outcomes. The purpose of this article is to describe the implementation of an SDM structure at a pediatric hospital. The hospital's chief nurse officer charged a group of nurses with developing SDM guidelines to outline the purpose, structure, and function of unit councils. A targeted, multifaceted approach to the implementation of these guidelines led to the successful standardization of nine existing unit councils and the expansion of the SDM unit council structure to all other hospital units. Work continues with guideline refinement in response to the...



Antenatal Steroids Averting Brain Bleeds in Preemies

Fri, 25 Mar 2016 12:35:03 +0100

(MedPage Today) -- Another study supports steroids in high-risk pregnancies (Source: MedPage Today Pediatrics)



Chronic pancreatitis: Bently says he’s ‘ready for a new belly’

Fri, 25 Mar 2016 12:28:24 +0100

  Bently Barnes (center) with Dr. Victor Fox and Dr. Amit Grover, co-directors of the Pancreatic Disorders Program Four-year-old Bently Barnes needed to get ready. He opened the closet door, reached for his camouflage backpack, then scanned his bedroom for the essentials. He grabbed his favorite stuffed animal named, “Marshall,” a truck, tractor and his most prized possession – his blanket. He placed them in his backpack with care, zipped the travel bag and placed it next to his bed. Bently told his mom he was packed and ready to travel from their home in North Carolina to Boston Children’s Hospital. And he was “ready for a new belly,” he said. Early signs of chronic pancreatitis Bently’s mom, Nicole Barnes says her son’s stomach pain began well before his 2...



Lupus patients’ transition to adult care leaves gaps, delays in care

Fri, 25 Mar 2016 11:40:19 +0100

Patients with childhood-onset systemic lupus erythematosus (SLE) who transitioned to adult care without a formal transitioning process had long periods without care despite having moderate disease... (Source: Pediatric News)



Symptom Association: An Imperfect Pairing

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)



The Gut Is a Key Player in Cystic Fibrosis Malnutrition

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)

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Fe-D Up: Ending Iron and Vitamin D Deficiency in Toddlers

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)



Epigenetics in Paediatric Gastroenterology, Hepatology, and Nutrition: Present Trends and Future Perspectives

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Epigenetics can be defined as stable, potentially heritable changes in the cellular phenotype caused by mechanisms other than alterations to the underlying DNA sequence. As such, any observed phenotypic changes including organ development, aging, and the occurrence of disease could be driven by epigenetic mechanisms in the presence of stable cellular DNA sequences. Indeed, with the exception of rare mutations, the human genome-sequence has remained remarkably stable over the past centuries. In contrast, substantial changes to our environment as part of our modern life style have not only led to a significant reduction of certain infectious diseases but also seen the exponential increase in complex traits including obesity and multifactorial diseases such as autoimmune disorders. ...



Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders

Fri, 25 Mar 2016 11:13:48 +0100

Objective: Pruritus is a common symptom of cholestatic liver disorders. The present study aimed at evaluating autotaxin (ATX), a lysophospholipase recently identified as potential cause for cholestatic pruritus, in pediatric cholestatic diseases presenting with or without itching. Methods: A cohort of 45 children consisting of 14 patients experiencing itching (Alagille syndrome [n = 10], complete extrahepatic biliary atresia [n = 2], neonatal sclerosing cholangitis (n = 1), progressive familial intrahepatic cholestasis type 2 [n = 1]), 9 patients with bile acid synthesis defects (3β-hydroxy-C27-steroid-oxidoreductase [n = 7] and Δ4–3-oxosteroid-5β-reductase deficiency [n = 2]), and 22 healthy children were studied. Serum ATX activity and total serum bile salt ...



Home-Based Screening for Biliary Atresia Using Infant Stool Color Cards in Canada: Quebec Feasibility Study

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: The high enrollment and utilization rates in this screening study strongly support the feasibility of implementing a Canadian SCC screening program to improve outcomes of children with BA. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Hepatoblastoma in Children With Congenital Portosystemic Shunts

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Two children developed hepatoblastoma concurrent with congenital portosystemic shunts (PSSs) (Abernethy malformations). Both underwent operative ligation of their PSSs. One received concurrent tumor resection, whereas the other was deemed initially unresectable and underwent biopsy followed by neoadjuvant chemotherapy. Although benign hepatic masses, such as focal nodular hyperplasia and nodular regenerative hyperplasia, are common in patients with Abernethy malformations, malignant tumors have also been documented and should always be considered in the differential diagnosis of a patient with a congenital PSS and a hepatic mass. (Source: Journal of Pediatric Gastroenterology and Nutrition)

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Resolution of Hepatic Artery Thrombosis in 2 Pediatric Liver Transplant Patients

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Hepatic artery thrombosis (HAT) is a serious complication after liver transplantation. This is the first report of spontaneous resolution of HAT in pediatric liver transplant patients on low molecular weight heparin therapy. A total of 2 patients, a 26-month-old boy who presented with acute liver failure and required emergent liver transplantation and a 15-year-old boy with ulcerative colitis and autoimmune hepatitis-primary sclerosing cholangitis overlap underwent liver transplantation for progressive cirrhosis; both developed HAT during the postoperative period. They were both treated with low molecular weight heparin. Follow-up imaging for both patients showed resolution of HAT without evidence of collateral flow. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Liver Disease in Pediatric Patients With Ataxia Telangiectasia: A Novel Report

Fri, 25 Mar 2016 11:13:48 +0100

Objective: Ataxia telangiectasia (A-T) is a rare genetic multiorgan disease. Although gastrointestinal involvement is known, hepatic involvement in A-T has not been investigated. We aimed to study the hepatic involvement in a large cohort of patients with A-T. Methods: A retrospective review of patients, studied from January 1986 to January 2015 at a National A-T Center. Clinical data including demographic, genetic, laboratory, nutritional, radiographic, and histological data were retrieved. Results: Fifty-three patients, 27 (49%) boys, age 14.6 ± 5.2 years (range 5.9–26.1 years), were included. Twenty-three patients (43.4%), age 9.9 ± 5.1 years, had consistently abnormal liver enzymes. The mean enzyme levels were alanine aminotransferase 76.8 ± 73.8 IU/L, aspartate am...



Temporal Association Between Reflux-like Behaviors and Gastroesophageal Reflux in Preterm and Term Infants

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: The prevalence of GER as detected by MII-pH was low (10%) in symptomatic preterm and term infants. The incidence and pattern of GER was similar in preterm and term infants. The majority of suspected clinical reflux behaviors did not correlate with reflux events. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Endoscopic Surveillance After Repair of Oesophageal Atresia: Longitudinal Study in 209 Patients

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: EFU revealed frequent oesophagitis and metaplasia, but no dysplasia or cancer. Routine endoscopic surveillance had limited benefit and seems unnecessary during childhood after repair of OA. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Novel Associations Between Major Histocompatibility Complex and Pediatric-onset Inflammatory Bowel Disease

Fri, 25 Mar 2016 11:13:48 +0100

This study focused on MHC association of genes with pediatric-onset IBD and its different phenotypes. Methods: Blood samples of 103 patients with pediatric IBD (Crohn disease or ulcerative colitis) were collected at Children's Hospital, University of Helsinki, Finland. HLA-A, -B, -DRB1 alleles and complement C4A and C4B gene copy numbers were determined and constructed into haplotypes by a Bayesian algorithm (PHASE). A general population cohort (n = 149) served as a control. HLA-alleles and C4 deficiency frequencies were compared between patients and controls with χ2-squared and Fisher exact test with Bonferroni correction (Pcorr). Results: One MHC haplotype HLA-A*03; HLA-B*07; 1 C4A gene; 1 C4B gene; HLA-DRB1*15 was more common in Crohn disease and ulcerative colitis than in contro...

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Prevalence of Peripheral Eosinophilia at Diagnosis in Children With Inflammatory Bowel Disease

Fri, 25 Mar 2016 11:13:48 +0100

Background and Objective: Inflammatory bowel disease (IBD) encompasses 2 disorders of unknown etiology: Crohn disease (CD) and ulcerative colitis (UC). There has been a continuous search for markers for disease activity. Eosinophils are granulocytic leukocytes that are implicated in the pathogenesis of IBD. The aim of this study was to examine the prevalence and significance of peripheral eosinophilia (PE) at diagnosis in children with IBD. Methods: A comprehensive chart review of all children with diagnosed as having IBD between January 2006 and August 2014 was performed. Patients with PE at diagnosis were compared with those without in relation to disease clinical activity and disease course. Results: A total of 109 children (mean age 14.6 ± 2.77, range 4.5–17.9 years, 55 boys) with...



Early Clinical Diagnosis of PC1/3 Deficiency in a Patient With a Novel Homozygous PCSK1 Splice-Site Mutation

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Autosomal recessive proprotein convertase 1/3 (PC1/3) deficiency, caused by mutations in the PCSK1 gene, is characterized by severe congenital malabsorptive diarrhea, early-onset obesity, and certain endocrine abnormalities. We suspected PC1/3 deficiency in a 4-month-old girl based on the presence of congenital diarrhea and polyuria. Sequencing the whole coding region and splice sites detected a novel homozygous PCSK1 splice-site mutation, c.544–2A>G, in the patient. The mutation resulted in the skipping of exon 5, the generation of a premature termination codon, and nonsense-mediated PCSK1 messenger ribonucleic acid decay, which was demonstrated in complementary DNA derived from fibroblasts. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Definitions and Outcome Measures in Pediatric Functional Upper Gastrointestinal Tract Disorders: A Systematic Review

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: Different outcome measures are used in therapeutic trials on functional disorders of the upper gastrointestinal tract. There is a clear paucity of trials evaluating different treatment regimens regarding CVS, ARS, and aerophagia. Uniform definitions, outcome measures, and validated instruments are needed to make a comparison between intervention studies possible. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Abdominal Pain-predominant Functional Gastrointestinal Disorders in Adolescent Nigerians

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: AP-FGIDs are a significant health problem in Nigerian adolescents. In addition to the intestinal symptoms, most of the affected children and others also had extraintestinal symptoms. None of the stressful life events evaluated was significantly associated with FGIDs. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Follow-up in Childhood Functional Constipation: A Randomized, Controlled Clinical Trial

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: Improved self-management behavior caused by access to self-motivated Web-based information induced faster short-term recovery during the treatment of functional constipation. Patient empowerment rather than health care–promoted follow-up may be a step toward more effective treatment for childhood constipation. (Source: Journal of Pediatric Gastroenterology and Nutrition)

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Age of Onset of Functional Constipation

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: In a review of 538 children with functional constipation, we analyzed ages of presentation and onset, symptom duration, and behavioral/developmental problems. We divided the subjects into quartiles (Q1–Q4) based on age of onset. Median onset age was 2.3 years. The oldest group had the shortest symptom duration before referral at 1.8 ± 1.8 years (compared with Q3 to Q1, P = 0.039, P = 0.001, P  (Source: Journal of Pediatric Gastroenterology and Nutrition)



Health-Related Quality of Life in Spanish Children With Coeliac Disease

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: The CDDUX questionnaire emerged as reliable for use in Spanish children with celiac disease. Overall, both children and parents felt the disease had no substantial negative impacts on patient HRQOL. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Toxic-metabolic Risk Factors in Pediatric Pancreatitis: Recommendations for Diagnosis, Management, and Future Research

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Pancreatitis in children can result from metabolic and toxic risk factors, but the evidence linking these factors is sparse. We review the evidence for association or causality of these risk factors in pancreatitis, discuss management strategies, and their rationale. We conducted a review of the pediatric pancreatitis literature with respect to the following risk factors: hyperlipidemia, hypercalcemia, chronic renal failure, smoking exposure, alcohol, and medications. Areas of additional research were identified. Hypertriglyceridemia of 1000 mg/dL or greater poses an absolute risk for pancreatitis; persistent elevations of calcium are predisposing. Further research is necessary to determine whether end-stage renal disease leads to increased pancreatitis in children similar to adu...



Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: LXS had improved choline intake, plasma choline status, and muscle choline stores compared with placebo group. The choline-rich supplement was safe, accepted by participants, and improved choline status in children with CF. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Decreased Expression of Enterocyte Nutrient Assimilation Genes and Proteins in the Small Intestine of Cystic Fibrosis Mouse

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: These studies suggest that the environment of the CF intestinal lumen plays a role in reduced maturation of enterocytes. Because changing the gut lumen environment can affect enterocyte maturation, this is not a cell-autonomous effect of loss of CF transmembrane conductance regulator. (Source: Journal of Pediatric Gastroenterology and Nutrition)

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Iron and Vitamin D Deficiency in Healthy Young Children in Western Europe Despite Current Nutritional Recommendations

Fri, 25 Mar 2016 11:13:48 +0100

This study took place in Germany, the Netherlands, and the United Kingdom from 2012 to 2014. A venous blood sample was taken to establish iron and vitamin D status. ID was defined as serum ferritin (Source: Journal of Pediatric Gastroenterology and Nutrition)



Serum Vitamin D Depends Less on Latitude Than on Skin Color and Dietary Intake During Early Winter in Northern Europe

Fri, 25 Mar 2016 11:13:48 +0100

Objectives: To evaluate if dietary vitamin D intake is adequate for sufficient vitamin D status during early winter in children living in Sweden, irrespective of latitude or skin color. Methods: As part of a prospective, comparative, 2-center intervention study in northern (63°N) and southern (55°N) Sweden, dietary intake, serum 25-hydroxyvitamin D (S-25(OH) D), associated laboratory variables, and sociodemographic data were studied in 5 to 7-year-old children with fair and dark skin in November and December. Results: Two hundred six children with fair/dark skin were included, 44/41 and 64/57 children in northern and southern Sweden, respectively. Dietary vitamin D intake was higher in northern than southern Sweden (P = 0.001), irrespective of skin color, partly due to higher consu...



Growth, Nutrition, and Cytokine Response of Breast-fed Infants and Infants Fed Formula With Added Bovine Osteopontin

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: Addition of OPN to infant formula changes amino acid metabolism and cytokine responses of FF infants and makes them more similar to BF infants. The lower prevalence of pyrexia in the F130 infants than in F0 infants suggests that adding OPN may confer health benefits. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Intensive, Manual-based Intervention for Pediatric Feeding Disorders: Results From a Randomized Pilot Trial

Fri, 25 Mar 2016 11:13:48 +0100

Objectives: The aim of this pilot study was to investigate feasibility and preliminary efficacy of an intensive, manual-based behavioral feeding intervention for children with chronic food refusal and dependence on enteral feeding or oral nutritional formula supplementation. Methods: Twenty children ages 13 to 72 months (12 boys and 8 girls) meeting criteria for avoidant/restrictive food intake disorder were randomly assigned to receive treatment for 5 consecutive days in a day treatment program (n = 10) or waitlist (n = 10). A team of trained therapists implemented treatment under the guidance of a multidisciplinary team. Parent training was delivered to support generalization of treatment gains. We tracked parental attrition and attendance, as well as therapist fidelity. Primary...



A Multiseptated Gallbladder in a 16-Year-Old Boy With Abdominal Pain

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)

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Ustekinumab for Resistant Pediatric Crohn Disease

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)



HFE-Related Hereditary Hemochromatosis Is Not Invariably a Disease of Adulthood: Importance of Early Diagnosis and Phlebotomy in Childhood

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)



Same Quality but Not the Same Impact: Citations Related to Publications About Celiac Disease in JPGN and AJG

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)



Authors’ Response

Fri, 25 Mar 2016 11:13:48 +0100

No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)