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MedWorm: Osteomyelitis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Osteomyelitis category.



Last Build Date: Tue, 29 Mar 2016 16:30:59 +0100

 



Bacteriological profile of chronic osteomyelitis in a tertiary care hospital in South India

Tue, 29 Mar 2016 09:23:39 +0100

Background: Chronic osteomyelitis (COM) is a major medical problem in most countries, mainly associated with violent trauma, modern surgery and inadequate treatment of acute osteomyelitis. Although the incidence of osteomyelitis has reduced to a certain extent with the advent of antibiotics and chemotherapeutic agents, yet it continues to be a major problem in India. (Source: International Journal of Infectious Diseases)

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Tuberculous osteomyelitis of mid-clavicle in a healthy normal girl

Tue, 29 Mar 2016 09:23:36 +0100

Background: 16 year old girl with no known comorbidities presented with complaints of painful restriction of movement of left shoulder with no history of fever followed by development of a swelling over the left mid clavicular region. The swelling was painful with pain radiating to the left arm. (Source: International Journal of Infectious Diseases)



Mp56-16 radiographic manifestations of pubic symphysis osteomyelitis in the prostate cancer survivor: definitive diagnosis lies in findings on magnetic resonance imaging

Mon, 28 Mar 2016 19:24:09 +0100

Pubic symphysis osteomyelitis (PSO) represents a debilitating complication of radiation and ablative treatments for prostate cancer. The definitive radiographic diagnosis of this is not described. In this review, we characterize the plain film radiographic and magnetic resonance imaging (MRI) findings of PSO in prostate cancer survivors treated at a tertiary referral center providing multidisciplinary treatment for PSO. (Source: The Journal of Urology)



Mp56-15 urodynamic features of pubic symphysis osteomyelitis in the prostate cancer survivor

Mon, 28 Mar 2016 19:24:09 +0100

Pubic symphysis osteomyelitis in the prostate cancer survivor represents a complication of radiation and ablative treatments for prostate cancer, characterized by recurrent pelvic abscess, pubic pain and difficulty with ambulation. Pubic symphysectomy with or without pubic rami debridement, along with concomitant urinary and/or fecal diversion is utilized for long term management of this debilitating condition. In this review we sought to evaluate the urodynamic features of this cohort. (Source: The Journal of Urology)



Mp36-02 microbiological profile and drug susceptibility patterns of pubic symphysis osteomyelitis in the prostate cancer survivor

Mon, 28 Mar 2016 19:24:05 +0100

Pubic symphysis osteomyelitis is seen in patients who have undergone prior radiation or other ablative therapy for treatment of their prostate cancer and presents up to 7 to 10 years later with pelvic pain. In this review we sought to delineate the microbiological features and antibiotic susceptibility patterns of pubic symphysis osteomyelitis in the prostate cancer survivor. (Source: The Journal of Urology)



Pd44-04 diagnosis and management of pubic osteomyelitis associated with genitourinary fistula

Mon, 28 Mar 2016 19:24:04 +0100

We sought to evaluate the clinical diagnosis and management of patients with pubic osteomyelitis and genitourinary (GU) fistula at a single institution. Although associated with significant patient morbidity, there is a dearth of literature on this rare disease process. (Source: The Journal of Urology)

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Endoscopically-assisted operations in the treatment of odontogenic peripheral osteomyelitis of the posterior mandible

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): Zixian Huang, Zhiquan Huang, Daming Zhang, Huijun Hu, Qixiang Liang, Weiliang Chen The aim of this study was to evaluate the possibility of using an endoscope in the treatment of five patients with odontogenic peripheral osteomyelitis of the posterior mandible diagnosed between March 2012 and September 2014. After imaging and general preoperative examination, the patients had endoscopically-assisted curettage and sequestrectomy. The data collected included the duration of the operation, complications, and patients’ degree of satisfaction. The mean duration of the operation through an intraoral incision, was 46 (range 40-60) minutes. Patients were followed up at 1 w...



Sternoclavicular joint septic arthritis with chest wall abscess in a healthy adult: a case report

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Septic arthritis of the sternoclavicular joint is an unusual infection, especially in otherwise healthy adults. Because it is associated with serious complications such as chest wall abscess, prompt diagnosis and appropriate treatment are required. (Source: Journal of Medical Case Reports)



Endoscopically-assisted operations in the treatment of odontogenic peripheral osteomyelitis of the posterior mandible

Fri, 25 Mar 2016 23:00:00 +0100

The aim of this study was to evaluate the possibility of using an endoscope in the treatment of five patients with odontogenic peripheral osteomyelitis of the posterior mandible diagnosed between March 2012 and September 2014. After imaging and general preoperative examination, the patients had endoscopically-assisted curettage and sequestrectomy. The data collected included the duration of the operation, complications, and patients’ degree of satisfaction. The mean duration of the operation through an intraoral incision, was 46 (range 40-60) minutes. (Source: The British Journal of Oral and Maxillofacial Surgery)



Severe tooth loss after root damage caused by predrilled intermaxillary fixation screw: a case report

Wed, 23 Mar 2016 20:13:42 +0100

Abstract Intermaxillary fixation (IMF) with screws is routinely used as a conservative therapy or to obtain normal occlusion during the surgical procedure of open reduction and internal fixation for treating mandibular fractures. The risk of iatrogenic dental damage caused by interdental drilling is widely known. Several side effects are described, including loss of response to pulp sensibility testing, root fracture, and, loss of the tooth. This is a case report about a young man who had undergone temporary IMF treatment with a single proven root damage. The patient did not appear for follow‐up but he presented 5 years afterward with local purulent osteomyelitis concerning the affected and the adjacent teeth. Osteotomy and extraction of two premolars and one molar were necessary for reh...



Calcaneal Osteomyelitis Associated With a Severe Abscess

Tue, 22 Mar 2016 23:00:00 +0100

Publication date: Available online 14 March 2016 Source:Journal of the American College of Clinical Wound Specialists Author(s): Ali Memis, Mesut Mutluoglu, Sinan Öztürk, Kemal Kara, Hakan Ay Diabetic foot osteomyelitis (DFO) is a common complication of the diabetic foot (Gibbons, 1987) and the majority of minor and major amputations are preceded by DFO (Mutluoglu et al., 2013). The diagnosis and treatment of DFO are both challenging. Early recognition and comprehensive management of diabetic foot infections may obviate DFO, hence the dreadful consequence-resection of the infected bone. Herein, we present the successful management of a patient presenting with DFO and severe abscess formation of the heel. (Source: Journal of the American College of Clinical Wound Specialists)

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Pediatric hypervirulent Klebsiella pneumoniae septic arthritis

Tue, 22 Mar 2016 23:00:00 +0100

Abstract Cases of infection with hypervirulent Klebsiella pneumoniae are gradually increasing in number, and cause life‐threatening community‐acquired infection even in immunocompetent patients. A 14‐year‐old boy developed septic hip arthritis due to hypervirulent K. pneumoniae (sequence type 23, serotype K1, magA positive). The patient initially seemed to have been successfully treated with antibiotics and surgical intervention, but septic arthritis developed into osteomyelitis of the femoral head and myositis, which required long‐term antibiotic therapy and additional surgical intervention. This is the first pediatric case of hypervirulent K. pneumoniae septic hip arthritis. Treatment plans should mainly consist of antibiotic therapy and surgical intervention. Clinicians, even ...



Id: 49: study of minimum inhibitory concentration of cefazolin for methicillin sensitive staphylococcus aureus and correlation with oxacillin susceptibility

Mon, 21 Mar 2016 23:00:00 +0100

Conclusion The MIC of cefazolin for MSSA determined by in vitro susceptibility to oxacillin was entirely in the susceptible range with 100% correlation. Daptomycin, ceftaroline and telavancin are suitable alternative antibiotics for treatment of patients with infections due to MSSA in whom anti-staphylococcal penicillins cannot be used due to penicillin allergic, intolerance, and/or non-availability since there is not much resistance to these antibiotics in MSSA. (Source: Journal of Investigative Medicine)



Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO)

Sun, 20 Mar 2016 23:00:00 +0100

Abstract Chronic recurrent multifocal osteomyelitis (CRMO), the most severe form of chronic nonbacterial osteomyelitis, is an autoinflammatory bone disorder. A timely diagnosis and treatment initiation is complicated by the absence of widely accepted diagnostic criteria and an incomplete pathophysiological understanding. The aim of this study was to determine biomarkers for the diagnosis and follow-up of CRMO. Serum of 56 CRMO patients was collected at the time of diagnosis. As controls, sera from treatment-naïve age-matched patients with Crohn’s disease (N = 62) or JIA (N = 28) as well as healthy individuals (N = 62) were collected. Multiplex analysis of 25 inflammation markers was performed. Statistical analysis was performed using Kruskal–Wallis and Mann–Whitney U ...



Mesenchymal stem cell proliferation and mineralization but not osteogenic differentiation are strongly affected by extracellular pH

Sat, 19 Mar 2016 00:00:00 +0100

Osteomyelitis is a serious complication in oral and maxillofacial surgery affecting bone healing. Bone remodeling is not only controlled by cellular components but also by ionic and molecular composition of the extracellular fluids in which calcium phosphate salts are precipitated in a pH dependent manner. (Source: Journal of Cranio-Maxillofacial Surgery)



Tubercular osteomyelitis of the of first metatarsal bone as a cause of forefoot pain

Sat, 19 Mar 2016 00:00:00 +0100

Tuberculosis (TB) has been known to mankind since ancient times and remains a major health problem in currently developing countries. Less than 10% of musculoskeletal tuberculosis involves foot and ankle. [1,2] The diagnosis of TB of the foot is often overlooked because of the ambiguous symptoms and lack of awareness regarding the disease at atypical sites which can lead to delay in the initiation of treatment. The joint involvement is the most common initial presentation of ankle and foot tuberculosis. (Source: The Foot)



A Prospective, Randomized, Multicenter, Controlled Evaluation of the Use of Dehydrated Amniotic Membrane Allograft Compared to Standard of Care for the Closure of Chronic Diabetic Foot Ulcer.

Thu, 17 Mar 2016 17:27:02 +0100

CONCLUSION: The results suggest DAMA is safe and effective in the management of DFUs, but additional research is needed. PMID: 26978860 [PubMed - in process] (Source: Wounds)



Silver-Collagen Dressing and High-voltage, Pulsed-current Therapy for the Treatment of Chronic Full-thickness Wounds: A Case Series.

Wed, 16 Mar 2016 11:32:01 +0100

Authors: Zhou K, Krug K, Stachura J, Niewczyk P, Ross M, Tutuska J, Ford G Abstract Research suggests high-voltage, pulsed-current electric therapy (HVPC) is safe and effective for treating chronic wounds, and some data suggest silver- and collagen-based dressings may facilitate healing. A combination therapy utilizing both HVPC and silver-collagen dressing may present clinical advantages. To explore the effect of the combined therapy for chronic full-thickness wounds, a prospective, consecutive case series study was conducted. All participants were adults with wounds of at least 6 weeks' duration. After obtaining informed consent, patient and wound characteristics were obtained, wounds were assessed and measured, and patients received 2 to 3 HVPC treatments per week followed by ap...



A Prospective, Descriptive Study to Assess the Clinical Benefits of Using Calendula officinalis Hydroglycolic Extract for the Topical Treatment of Diabetic Foot Ulcers.

Wed, 16 Mar 2016 11:32:01 +0100

Authors: Buzzi M, de Freitas F, Winter M Abstract Diabetic foot ulcers (DFUs) have a significant impact on patient quality of life. A prospective, descriptive pilot study was conducted between May 2012 and December 2013 through the dermatology outpatient unit in a Brazilian hospital to evaluate the clinical benefits of using Calendula officinalis hydroglycolic extract in the treatment of DFUs. Patients diagnosed with a stable neuropathic ulcer of >3 months' duration; ranging in size from 0.5-40 cm2; without osteomyelitis, gangrene, bone exposure, cancer, or deep tissue infection; ages 18-90 years; with adequate glycemic control and no history of an allergy to C. officinalis were enrolled. Patients provided demographic and diabetes-related information and were evaluated biweekly ...



Brodie’s abscess following percutaneous fixation of distal radius fracture in a child

Wed, 16 Mar 2016 00:00:00 +0100

We report the case of a Brodie’s abscess presenting five and a half years following closed reduction and percutaneous pinning of a distal radius fracture. The index surgery was complicated by a pin site infection that was treated successfully with antibiotics. The patient represented with forearm pain years later, and radiological investigations revealed a Brodie’s abscess in the distal radius at the site of the previous Kirschner wires. The Brodie’s abscess was managed through surgical curettage and antibiotics. Staphylococcus aureus and diphtheroid organisms were cultured from the intraoperative specimens. A Brodie’s abscess is a form of localised subacute osteomyelitis, which usually occurs in the metaphysis of long bones and can mimic malignancy. Previous trauma or surgery has ...

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Calcaneal Osteomyelitis Associated with a Severe Abscess

Tue, 15 Mar 2016 00:00:00 +0100

Publication date: Available online 14 March 2016 Source:Journal of the American College of Clinical Wound Specialists Author(s): Ali Memis, Mesut Mutluoglu, Sinan Öztürk, Kemal Kara, Hakan Ay Diabetic foot osteomyelitis (DFO) is a common complication of the diabetic foot (1) and the majority of minor and major amputations are preceded by DFO (2). The diagnosis and treatment of DFO are both challenging. Early recognition and comprehensive management of diabetic foot infections may obviate DFO, hence the dreadful consequence- resection of the infected bone. Herein we present the successful management of a patient presenting with DFO and severe abscess formation of the heel. (Source: Journal of the American College of Clinical Wound Specialists)



Streptococcus bovis septic arthritis and osteomyelitis: A report of 21 cases and a literature review

Tue, 15 Mar 2016 00:00:00 +0100

The Streptococcus bovis group (SBG) is a well-known cause of endocarditis, but its role in osteoarticular infections (OAIs) has not been well described. (Source: Seminars in Arthritis and Rheumatism)



Migration of a toothpick along the flexor tendon sheath in a lower extremity.

Mon, 14 Mar 2016 07:30:02 +0100

We report a case of a toothpick penetrating a child's foot and moving proximally along the tendon sheath. PMID: 26969963 [PubMed - in process] (Source: Acta Orthopaedica et Traumatologica Turcica)



Calcaneal Osteomyelitis Associated with a Severe Abscess

Mon, 14 Mar 2016 00:00:00 +0100

Diabetic foot osteomyelitis (DFO) is a common complication of the diabetic foot (1) and the majority of minor and major amputations are preceded by DFO (2). The diagnosis and treatment of DFO are both challenging. Early recognition and comprehensive management of diabetic foot infections may obviate DFO, hence the dreadful consequence- resection of the infected bone. Herein we present the successful management of a patient presenting with DFO and severe abscess formation of the heel. (Source: Journal of the American College of Certified Wound Specialists)



Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines.

Mon, 14 Mar 2016 00:00:00 +0100

Authors: Azar MM, Malinis MF Abstract Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is a disease of protean manifestations and of global distribution. Although increasingly reported in Asia, there are few reports from the Philippines. Here, we describe a case of microbiologically diagnosed histoplasmosis, probably acquired from the Philippines, in a returning traveler who presented with a right foot wound and papular rash. The final diagnosis was disseminated histoplasmosis with cutaneous and bone involvement, both unusual manifestations of the disease. PMID: 26976880 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)

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Calcaneal Osteomyelitis Associated With a Severe Abscess

Sun, 13 Mar 2016 23:00:00 +0100

Diabetic foot osteomyelitis (DFO) is a common complication of the diabetic foot (Gibbons, 1987) and the majority of minor and major amputations are preceded by DFO (Mutluoglu et al., 2013). The diagnosis and treatment of DFO are both challenging. Early recognition and comprehensive management of diabetic foot infections may obviate DFO, hence the dreadful consequence-resection of the infected bone. Herein, we present the successful management of a patient presenting with DFO and severe abscess formation of the heel. (Source: Journal of the American College of Certified Wound Specialists)



Predictors of Outcome in Pediatric Osteomyelitis: Five Years Experience in a Single Tertiary Center

Sat, 12 Mar 2016 19:07:26 +0100

Conclusions: A risk prediction model, utilizing information available shortly after hospitalization, allows early identification of children at greatest risk of developing complicated osteomyelitis. (Source: The Pediatric Infectious Disease Journal)



36 Radiographic manifestations of pubic symphysis osteomyelitis in the prostate cancer survivor: Definitive diagnosis lies in findings on magnetic resonance imaging

Sat, 12 Mar 2016 00:00:00 +0100

Publication date: March 2016 Source:European Urology Supplements, Volume 15, Issue 3 Author(s): G. Lavien, U. Zaid, A. Peterson (Source: European Urology Supplements)



Cryptococcal osteomyelitis: a report of 5 cases and a review of the recent literature

Fri, 11 Mar 2016 12:19:36 +0100

Summary Cryptococcus neoformans is a fungal pathogen associated with advanced HIV disease and other disorders associated with immune dysfunction. The pulmonary and the central nervous system are the most common manifestations of the disease. Localised osteomyelitis as the sole manifestation of extrapulmonary disease is rare. Herein, we present five cases of Cryptococcus osteomyelitis as the only manifestation of extrapulmonary disease. We also identified 84 additional cases of isolated cryptococcal osteomyelitis in the literature. Using these data, we have made some general recommendations regarding an approach to treatment of this uncommon clinical entity. (Source: Mycoses)



Vertebral Osteomyelitis Guidelines

Fri, 11 Mar 2016 00:00:00 +0100

(Source: Clinical Infectious Diseases)

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Complications, Outcomes in Vertebral Osteomyelitis SurgeryComplications, Outcomes in Vertebral Osteomyelitis Surgery

Thu, 10 Mar 2016 17:00:00 +0100

A new study examines the postoperative complications and reoperation rates after surgical treatment for vertebral osteomyelitis. Spine (Source: Medscape Orthopaedics Headlines)



The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus: an In Vivo Study.

Wed, 09 Mar 2016 00:00:00 +0100

Authors: Güzel Y, Golge UH, Goksel F, Vural A, Akcay M, Elmas S, Turkon H, Unver A Abstract We explored the ability of local and systemic applications of boric acid (BA) to reduce the numbers of methicillin-resistant Staphylococcus aureus (MRSA) in a rat model of tibial osteomyelitis (OM), and compared boric acid with vancomycin (V). Implant-associated osteomyelitis was established in 35 rats. After 4 weeks, at which time OM was evident both radiologically and serologically in all animals, the rats were divided into five groups of equal number: group 1, control group (no local application of BA or other medication); group 2, V group; group 3, local BA + V group; group 4, local BA group; and group 5, local + systemic BA group. Serum total antioxidant status, and the levels...



Community-acquired Methicillin-resistant Staphylococcus aureus Musculoskeletal Infections: Emerging Trends Over the Past Decade

Tue, 08 Mar 2016 07:34:28 +0100

Background: The emergence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has altered the management of pediatric musculoskeletal infections. Yet, institution-to-institution differences in MRSA virulence may exist, suggesting a need to carefully examine local epidemiological characteristics. The purpose of this study was to compare MRSA and methicillin-sensitive S. aureus (MSSA) musculoskeletal infections with respect to prevalence and complexity of clinical care over the past decade at a single children’s hospital. Methods: We retrospectively reviewed a series of patients presenting to The Children’s Hospital of Philadelphia with a diagnosis of osteomyelitis, septic arthritis, or both over a 10-year period. Inclusion criteria were S. aureus (SA) infections pr...



Vertebral osteomyelitis in adults: an update

Tue, 08 Mar 2016 00:00:00 +0100

Introduction The incidence of vertebral osteomyelitis is increasing, attributed to an ageing population with inherent co-morbidities and improved case ascertainment. Sources of data References were retrieved from the PubMed database using the terms ‘vertebral osteomyelitis' and ‘spondylodiscitis' between January 1, 2009 and April 30, 2014 published in English as checked in May 2014 (>1000 abstracts checked). Areas of agreement Blood cultures and whole spine imaging with magnetic resonance imaging are essential investigations. Thorough debridement is the mainstay of surgical management, although placing metalwork in active infection is becoming increasingly common. Areas of controversy The extent of pursuing spinal biopsies to determine aetiology, antimicrobial choices and...



Fusobacterium necrophorum otitis and mastoiditis in infants and young toddlers

Mon, 07 Mar 2016 00:00:00 +0100

Abstract There is an increased recovery of Fusobacterium necrophorum from cases of otitis media and mastoiditis in the pediatric population. These infections may be highly severe, causing local osteomyelitis, bacteremia, and Lemierre’s syndrome. The severity and difficulties in providing optimal treatment for these infections may be especially difficult in this age group due to immunological immaturity and delayed presentation. In this review of literature, we present and analyze the clinical presentation, management, and outcome of otic infections caused by F. necrophorum in infants and young toddlers less than 2 years old. Search in Pubmed was conducted for reported cases in the English literature for the time period of the last 50 years. Twelve well-described cases were ret...

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(i) Inferior heel pain

Thu, 03 Mar 2016 00:00:00 +0100

Inferior heel pain is a common complaint. Multiple differing pathologies may account for inferior heel pain. These may be classified by the anatomical structure affected: bone, nerve, plantar fascia and other soft tissues.Bony pathologies include calcaneal stress fracture, calcaneal bone marrow oedema, tumours and osteomyelitis. Neurological causes include tarsal tunnel syndrome, nerve to abductor digiti quinti neuropathy, medial calcaneal neuropathy and lumbo-sacral radiculopathy. The plantar fascia may be degenerate (fasciosis), torn or enthesopathic, or there may be peri-fascial oedema. (Source: Orthopaedics and Trauma)



Effects of Implant-Associated Osteomyelitis on Cefuroxime Bone Pharmacokinetics: Assessment in a Porcine Model

Wed, 02 Mar 2016 00:00:00 +0100

Conclusions: Cefuroxime penetration into infected cancellous bone was incomplete but comparable with that in healthy bone. The destructive bone processes associated with acute osteomyelitis reduced cefuroxime penetration further. Clinical Relevance: These findings support the general clinical perception that fast diagnosis and early initiation of antibiotics before the development of implant-associated cavities is important in nonsurgical management of acute osteomyelitis. (Source: JBJS)



Oral Ambulatory Treatment of Acute Osteomyelitis in Children: A Case-Control Study

Tue, 01 Mar 2016 06:00:00 +0100

Abstract: The treatment of acute hematogenous osteomyelitis has evolved in recent years to a shorter parenteral treatment with an early switch to the oral route. Current publications recommend a 2- to 4-day parenteral treatment before the oral switch. We retrospectively analyzed a series of 45 children aged 1 to 11 years and treated in our department for acute osteomyelitis without severity criterion. Nineteen of 45 patients were treated by an exclusive ambulatory oral treatment by amoxicillin and clavulanic acid. Twenty six of 45 patients had a 2- to 4-day parenteral treatment before the oral switch. The minimum follow-up was 6 months. The primary endpoint was a clinical, radiographic, and biologic healing, 6 months after the beginning of the treatment. The secondary endpoints evaluated w...



Fanconi Syndrome and Antiretrovirals: It Is Never Too Late

Tue, 01 Mar 2016 06:00:00 +0100

We present a case of life-threatening FS which developed in a 37-year-old woman with HIV after 8 years of asymptomatic tenofovir use. The patient was diagnosed with HIV in 1996 at 20 years of age, hepatitis C 10 years later, and Staphylococcus aureus sepsis with secondary osteomyelitis of the spine 3 years before admission for FS. She developed nausea, vomiting, diarrhea, and generalized weakness over a 2-week time period and presented to the hospital. In the emergency department, her serum potassium was 1.5 mEq/L, bicarbonate was 12 mEq/L, chloride was 111 mEq/L, phosphorus was 1.8 mg/dL, and creatinine was 1.95 mg/dL (baseline, 1.4). Arterial blood gas revealed a non–anion gap (hyperchloremic) metabolic acidosis. Type 2 renal tubular acidosis induced by antiretroviral therapy (ART) was...



Emergence of Refractory Otomastoiditis Due to Nontuberculous Mycobacteria: Institutional Experience and Review of the Literature

Tue, 01 Mar 2016 00:00:00 +0100

Conclusions. NTM otomastoiditis should be suspected if a patient has chronic refractory otorrhea and ear granulation tissue. Surgery, which is the mainstay of treatment, should be complemented with antibiotics. In those without temporal bone osteomyelitis, antibiotic treatment can be stopped after a dry ear is achieved. (Source: Clinical Infectious Diseases)

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Biofilm formation increases treatment failure in Staphylococcus epidermidis device‐related osteomyelitis of the lower extremity in human patients

Tue, 01 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Orthopaedic Research)



Predictors of Outcomes in Diabetic Foot Osteomyelitis Treated Initially With Conservative (Nonsurgical) Medical Management: A Retrospective Study

Tue, 01 Mar 2016 00:00:00 +0100

The optimal way to manage diabetic foot osteomyelitis remains uncertain, with debate in the literature as to whether it should be managed conservatively (ie, nonsurgically) or surgically. We aimed to identify clinical variables that influence outcomes of nonsurgical management in diabetic foot osteomyelitis. We conducted a retrospective study of consecutive patients with diabetes presenting to a tertiary center between 2007 and 2011 with foot osteomyelitis initially treated with nonsurgical management. Remission was defined as wound healing with no clinical or radiological signs of osteomyelitis at the initial or contiguous sites 12 months after clinical and/or radiological resolution. Nine demographic and clinical variables including osteomyelitis site and presence of foot pulses were ana...



Erythrocyte sedimentation rate and C‐reactive protein to monitor treatment outcomes in diabetic foot osteomyelitis

Tue, 01 Mar 2016 00:00:00 +0100

This study sought to evaluate the effectiveness of the inflammatory markers, erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP), in monitoring treatment of osteomyelitis in the diabetic foot. We screened 150 charts of patients admitted to our hospital with diabetic foot osteomyelitis (DFO), confirmed by positive results of bone culture and/or histopathology. We included patients who had an initial ESR/CRP within 72 hours of admission and two reported follow‐up values. We dichotomised patients based on the outcomes wound healing, re‐infection, recurrent ulceration, re‐hospitalisation, additional surgery, re‐amputation and death, all within 12 months, and analysed the trajectories of the markers over time. Our primary outcome, DFO remission, was defined as wound heal...



Ceftolozane/Tazobactam Pharmacokinetics in a Critically Ill Adult Receiving Continuous Renal Replacement Therapy

Mon, 29 Feb 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)



Thorn-Induced Alternaria Septic Arthritis and Osteomyelitis of the Hand

Mon, 29 Feb 2016 08:34:23 +0100

We report a healthy 49-year-old man with septic arthritis and osteomyelitis of the second MCP joint caused by the dematiaceous fungus Alternaria. This infection was acquired via thorn penetration into the radial aspect of the second MCP joint while gardening. To our knowledge, this is the first reported case of Alternaria septic arthritis and osteomyelitis in a healthy man. (Source: Infectious Diseases in Clinical Practice)

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Salmonella Epidural Abscess in a Patient With Rheumatoid Arthritis Treated With Tocilizumab

Mon, 29 Feb 2016 08:34:23 +0100

Abstract: A 59-year-old woman with a 23-year history of rheumatoid arthritis and treated with tocilizumab for the previous 6 months was referred to the neurosurgery service with neck pain and upper extremity paresthesias. Magnetic resonance imaging of the cervical spine showed an epidural abscess with associated vertebral osteomyelitis. Culture of a computed tomography–guided aspirate from the abscess grew Salmonella enteridis as did cultures from a subsequent surgical debridement with C4-5 vertebrectomies and C3-6 fusion. The patient subsequently recalled a diarrheal illness associated with consumption of tomatoes purchased from a farmers' market approximately 3 weeks before the onset of her symptoms. We postulate that, during that illness, she had transient Salmonella bacteremia with s...



Clinico-radiological improvement in an immunocompetent patient presented with scedosporium apiospermum osteomyelitis

Mon, 29 Feb 2016 00:00:00 +0100

Publication date: Available online 28 February 2016 Source:Journal of Clinical Orthopaedics and Trauma Author(s): Rahul Mohan, T.S. Gopakumar Scedosporium apiospermum is frequently found as a saprophyte in soil, sewage and contaminated water. Its manifestations in immunocompetent patients are usually localised and in immunodeficient patients, it causes invasive systemic diseases. We are reporting the case of a 40-year-old male, who presented with pain, oedema and multiple discharging sinuses over the lateral aspect of the left foot with history of thorn prick. On examination, there were multiple active sinuses with tenderness and local rise in temperature. Calcaneum on palpation showed a thickened and irregular surface with limitation of ankle and subtalar movements. Blood investigatio...



Ultrastructural analyses of alveolar bone in a patient with osteomyelitis secondary to osteopetrosis: A review of the literature

Thu, 25 Feb 2016 00:00:00 +0100

Osteopetrosis, also known as marble bone disease, or Albers-Schönberg disease, is a generic term for generalized sclerotic conditions caused by rare genetic disorders.1 The prevalence of the disease is estimated at 1 in 100,000 to 500,000.2 Osteopetrosis is classified into 3 types based on clinical forms and genetic transmission: infantile malignant (autosomal recessive), which is frequently fatal within the first few years of life; intermediate (autosomal recessive), which occurs in the first decade of life or allows a normal life expectancy; and benign (autosomal dominant), which allows a full life expectancy. (Source: Journal of Oral and Maxillofacial Surgery)



Clinical Application of Antimicrobial Bone Graft Substitute in Osteomyelitis Treatment: A Systematic Review of Different Bone Graft Substitutes Available in Clinical Treatment of Osteomyelitis.

Wed, 24 Feb 2016 15:50:04 +0100

Authors: van Vugt TA, Geurts J, Arts JJ Abstract Osteomyelitis is a common occurrence in orthopaedic surgery, which is caused by different bacteria. Treatment of osteomyelitis patients aims to eradicate infection by debridement surgery and local and systemic antibiotic therapy. Local treatment increases success rates and can be performed with different antimicrobial bone graft substitutes. This review is performed to assess the level of evidence of synthetic bone graft substitutes in osteomyelitis treatment. According to the PRISMA statement for reporting systematic reviews, different types of clinical studies concerning treatment of osteomyelitis with bone graft substitutes are included. These studies are assessed on their methodological quality as level of evidence and bias and t...



Complex Infection After Flatfoot Reconstruction

Wed, 24 Feb 2016 00:00:00 +0100

We present the case of a 49-year-old female who underwent flatfoot reconstruction, with a resultant Mycobacterium chelonae-abscessus infection and osteomyelitis postoperatively. (Source: Journal of Foot and Ankle Surgery)

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Incidence and Clinical Significance of Heterotopic Ossification After Partial Ray Resection

Wed, 24 Feb 2016 00:00:00 +0100

Heterotopic bone growth is a common finding after partial foot amputation that can predispose to recurrent wounds, osteomyelitis, and reamputation. Heterotopic ossification is the formation of excessive mature lamellar bone in the soft tissues adjacent to bone that is exacerbated by trauma or surgical intervention. The relevance of heterotopic ossification is dependent on its anatomic location. Its occurrence as a sequela of partial foot amputation can lead to prominence on the plantar aspect of the foot that can predispose the patient to recurrent neuropathic ulceration or preclude appropriate wound healing. (Source: Journal of Foot and Ankle Surgery)



Mycobacterium chelonae-abscessus Complex Infection After Flatfoot Reconstruction

Wed, 24 Feb 2016 00:00:00 +0100

We present the case of a 49-year-old female who underwent flatfoot reconstruction, with a resultant Mycobacterium chelonae-abscessus infection and osteomyelitis postoperatively. (Source: Journal of Foot and Ankle Surgery)



Tibiocalcaneal Fusion for Charcot Ankle With Severe Talar Body Loss: Case Report and a Review of the Surgical Literature

Tue, 23 Feb 2016 00:00:00 +0100

Publication date: March–April 2016 Source:The Journal of Foot and Ankle Surgery, Volume 55, Issue 2 Author(s): Takao Aikawa, Koji Watanabe, Hidenori Matsubara, Issei Nomura, Hiroyuki Tsuchiya Severe bone loss resulting from talar body necrosis in the Charcot ankle can be challenging to treat. In particular, the Charcot ankle will demonstrate progressive instability and deformity, causing protrusion of the medial or lateral malleolus, which will mostly lead to skin ulcers or osteomyelitis and, in some cases, will ultimately require transtibial amputation. Problems such as bone fragility, poor compliance with load-bearing restrictions, susceptibility to infection, and circulatory disorders cause difficulties in the surgical treatment of the Charcot ankle. We believe that tibiocalcan...



Staphylococcus lugdunensis: A Rare Pathogen for Osteomyelitis of the Foot

Tue, 23 Feb 2016 00:00:00 +0100

We present a unique case of acute osteomyelitis of a foot caused by S. lugdunensis after a patient stepped on a thorn. Our case is unique, because the radiographic changes were noted within 4 days, despite normal plain films and magnetic resonance images on the day of admission. This finding suggests the aggressiveness and virulence of S. lugdunensis. In addition, we report the first case of foot osteomyelitis as a result of isolated S. lugdunensis that involved 2 distinct specimens with 2 different antibiotic sensitivity reports. (Source: The Journal of Foot and Ankle Surgery)



Infectious Spondylodiscitis, Epidural Phlegmon, and Psoas Abscess Complicating Diabetic Foot Infection: A Case Report

Tue, 23 Feb 2016 00:00:00 +0100

We present the case of a 63-year-old male with right calcaneal osteomyelitis who developed acute onset lower back pain with concomitant fever and chills. Magnetic resonance imaging revealed L4-L5 vertebral osteomyelitis, a T9-L1 epidural abscess, and a right psoas muscle abscess secondary to hematogenous seeding from the calcaneus. The patient underwent right partial calcanectomy, spinal and right psoas abscess incision and drainage, and direct lumbar interbody fusion of L4-L5 with a right iliac crest allograft. All bone, blood, and abscess cultures were positive for methicillin-resistant Staphylococcus aureus. After the surgery, the patient's pain resolved in his back and hip and he regained full right lower extremity function. The 1-year follow-up examination revealed that the patient ha...

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Simplified Method for Treating Osteomyelitis of the Sternoclavicular Joint.

Mon, 22 Feb 2016 18:25:04 +0100

We report a case that was treated with single-stage resection of both the sternoclavicular joint and part of the sternum followed by implantation of calcium sulfate beads impregnated with antibiotics and primary closure without a muscle flap. A single-stage debridement with resection for osteomyelitis of the sternoclavicular joint and primary closure with calcium sulfate beads impregnated with antibiotics may be an option when dealing with this difficult clinical problem. PMID: 26897216 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)



Primary Tuberculous Osteomyelitis of the Mandible Mimicking a Parotid Gland Abscess

Mon, 22 Feb 2016 00:00:00 +0100

Abstract Tuberculosis has become a rare disease in the developed countries but it is still a serious problem in the developing countries. Incidence of tuberculous osteomyelitis of the jaw bones is very low. This rare incidence is the primary reason that the lesion gets misdiagnosed many times. Here we report the diagnosis, treatment and follow up of a case which is not a classical presentation of tuberculous osteomyelitis of mandible. Early diagnosis of tuberculous osteomyelitis will certainly reduce the morbidity of this disease condition. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)



Extension and Grading of Osteomyelitis are not Related to Limb Salvage in Charcot Neuropathic Osteoarthropathy: A Cohort Prospective Study

Sun, 21 Feb 2016 00:00:00 +0100

Charcot neuropathic osteoarthropathy (CN) represents a complication for diabetic patients which involves a progressive alteration of the osteoarticular apparatus with high risk of amputation. The aim of the study was to assess whether the localization of CN and the extent or grading of the osteomyelitis have an influence on the rate of limb salvage and the time to recovery. (Source: Journal of Diabetes and Its Complications)



Outcomes after Matched Unrelated Donor Stem Cell Transplantation in Chronic Granulomatous Disease – an Update

Fri, 19 Feb 2016 10:35:14 +0100

We report the safety and efficacy of HSCT in 23 children with Chronic Granulomatous Disease (CGD). The patients received a matched related donor (MRD) (n=6), matched unrelated donor (MUD)(n=13), or mismatched unrelated donor with one HLA locus mismatch (MMUD 9/10)(n=4). The median age was 5.5 years (range: 0.5-30 years) with x-linked (n=20), autosomal recessive (n=3), disease over a 12 year period (2003-2015). 19 children had significant clinical infections before transplant including: osteomyelitis (n=3), lung/ liver abscess requiring surgical intervention (n=3), fungal pneumonia (n=13) skin and rectal abscesses (n=6) and bacteremia (n=6). (Source: Biology of Blood and Marrow Transplantation)



Whole-body MRI: non-oncological applications in paediatrics

Fri, 19 Feb 2016 00:00:00 +0100

Abstract Whole-body magnetic resonance imaging (WBMRI) is a fast and accurate method for detecting and monitoring of diseases throughout the entire body without exposure to ionizing radiation. Among emerging non-oncological potential applications of WBMRI, rheumatological diseases play an important role. Rheumatological WBMRI applications include the evaluation of chronic multifocal recurrent osteomyelitis, dermatomyositis, fever of unknown origin, arthritis, and connective tissue diseases. Aim of this review is to give an overview of the use of WBMRI in rheumatological field. (Source: La Radiologia Medica)

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Free intra-osseous muscle transfer for treatment of chronic osteomyelitis.

Thu, 18 Feb 2016 04:08:02 +0100

CONCLUSION: The present study demonstrated that free intramedullary muscle transfers are effective in providing a high rate of success in the treatment of chronic osteomyelitis. The secondary filling of the intramedullary cavity after extensive removal of all infected bony sequesters has proven to give a long-term arrest of chronic osteomyelitis. PMID: 26059054 [PubMed - as supplied by publisher] (Source: Journal of Plastic Surgery and Hand Surgery)



Local antibiotic administration for diabetic foot osteomyelitis. Re: Karri VVSR, Kuppusamy G, Talluri SV, et al. Current and emerging therapies in the management of diabetic foot ulcers. Curr Med Res Opin 2015: published online 7 December 2015, doi: 10.1185/03007995.2015.1128888.

Thu, 18 Feb 2016 02:49:02 +0100

Authors: Papanas N, Panagopoulos P, Drosos G, Maltezos E PMID: 26709966 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)



A Rare Full-Term Newborn Case of Rib Osteomyelitis with Suspected Preceding Fracture

Thu, 18 Feb 2016 00:00:00 +0100

AJP Rep 2016; 06: e104-e107DOI: 10.1055/s-0035-1570320Acute osteomyelitis is uncommon in full-term neonates and occurs most frequently in those with critical illnesses, often following episodes of sepsis, skin infection, umbilical catheterization, urinary tract anomalies, or a complicated delivery. Here, we report a very rare case of acute rib osteomyelitis due to Staphylococcus aureus in a 13-day-old full-term male neonate. Ultrasonography (US) enabled diagnosis and revealed a coexisting costochondral junction rib fracture, which was not detected on routine chest radiography. Following a 29-day course of intensive parenteral antibiotic therapy, the patient was discharged in good health at 42 days of age without any scar formation. Due to its accessibility and safety, US can be a promising...



Landmarks for Sacral Debridement in Sacral Pressure Sores

Wed, 17 Feb 2016 18:07:10 +0100

Conclusions: The PSIS is a reliable landmark for localizing the S2/S3 junction and the termination of the dural sac. Sacral debridement medial to the sacral foramina above the level of PSIS must be conservative whenever possible. If aggressive debridement is necessary above this level, the surgeon must be alert to the possibility of dural involvement. (Source: Annals of Plastic Surgery)



Hepatic Reactive Amyloidosis Secondary to Chronic Osteomyelitis

Wed, 17 Feb 2016 00:00:00 +0100

Authors: Rotimi Ayoola & Sumanth Daram (Source: The American Journal of Gastroenterology)

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MR Imaging of Nontraumatic Musculoskeletal Emergencies

Wed, 17 Feb 2016 00:00:00 +0100

Many pathologies of the musculoskeletal system involve nontraumatic causes. MR imaging is used in the diagnosis because of its high sensitivity and specificity compared with other modalities. Osteomyelitis, osteonecrosis of the femoral head, and stress fractures are pathologies of bone where early diagnosis and intervention usually lead to an improved outcome. Joint aspiration and culture is the standard for diagnosing septic arthritis. MR imaging can support the diagnosis and allows evaluation for adjacent abscess and osteomyelitis. Early in the disease process, necrotizing fasciitis may not be clinically suspected and imaging may provide the first indication of the presence of this potentially deadly infection. (Source: Magnetic Resonance Imaging Clinics of North America)



Nuclear medicine imaging of bone infections

Wed, 17 Feb 2016 00:00:00 +0100

Osteomyelitis is a broad group of infectious diseases that involve the bone and/or bone marrow. It can arise haematogenously, via extension from a contiguous infection, or by direct inoculation during surgery or trauma. The diagnosis is not always obvious and imaging tests are frequently performed as part of the diagnostic work-up. Commonly performed radionuclide tests include technetium-99m (99mTc)-diphosphonate bone scintigraphy (bone), and gallium-67 (67Ga) and in vitro labelled leukocyte (white blood cell; WBC) imaging. (Source: Clinical Radiology)



Nuclear medicine imaging of posttraumatic osteomyelitis

Wed, 17 Feb 2016 00:00:00 +0100

Abstract Introduction Early recognition of a possible infection and therefore a prompt and accurate diagnostic strategy is essential for a successful treatment of posttraumatic osteomyelitis (PTO). However, at this moment there is no single routine test available that can detect osteomyelitis beyond doubt and the performed diagnostic tests mostly depend on personal experience, available techniques and financial aspects. Nuclear medicine techniques focus on imaging pathophysiological changes which usually precede anatomical changes. Together with recent development in hybrid camera systems, leading to better spatial resolution and quantification possibilities, this provides new opportunities and possibilities for nuclear medicine modalities to play an important...



Whole clavicle sequestration from chronic osteomyelitis in a 10 year old boy: a case report and review of the literature

Tue, 16 Feb 2016 00:00:00 +0100

Publication date: Available online 15 February 2016 Source:Annals of Medicine and Surgery Author(s): Agu Thaddeus Chika, Mathew E. Orjiaku Chronic osteomyelitis is a childhood disease and so it is not uncommon to diagnose it in a 10 year old boy who is suffering from pains and discharging sinuses from the left shoulder girdle. What is not common is the involvement of the clavicle in this infective process and even more uncommon is for the whole length of the clavicle to sequester. This case report describes a rare case of chronic osteomyelitis of the left clavicle in which the entire length was removed as a sequestrum during surgery. And despite the removal of an entire length of the clavicle in the patient, there was no functional deficit and there was also no shoulder asymmetry. (Sou...



Uganda: Osteomyelitis - Bone Infection That Causes Bones to Fall Out

Mon, 15 Feb 2016 07:00:16 +0100

[Monitor] Seeing a part of his bone fall out was shocking for Julius Ssebaka (pictured below). The seven-year-old had nursed a wound for almost three years. He felt a sharp pain and screamed one day as he sat next to his grandmother Mary Nalubega, a resident of Busana Village, Mubende District. (Source: AllAfrica News: Health and Medicine)

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Not by the Red on My Chinny Chin Chin: A Case of Mandibular Osteomyelitis in a 5-Year-Old Girl

Mon, 15 Feb 2016 00:00:00 +0100

Osteomyelitis is not an uncommon emergency department diagnosis in pediatric patients, and most cases are in the lower extremities. Children can present with acute, subacute, or chronic erythema, pain, swelling, or decreased use of the extremity; some patients will also have fever or elevated serum inflammatory markers, or both. (Source: The Journal of Emergency Medicine)



Headache and Facial Pain in Sickle Cell Disease

Mon, 15 Feb 2016 00:00:00 +0100

Abstract Children and adolescents with sickle cell disease (SCD) have a high prevalence of recurrent headaches (24.0–43.9 %). Acute presentation with headache can be diagnostically challenging, as the clinician must consider evaluation of several potentially devastating conditions including vascular diseases (stroke, hemorrhage, venous sinus thrombosis, moyamoya, posterior reversible encephalopathy syndrome), facial and orbital bone infarcts, dental pain, and osteomyelitis. Patients with SCD and primary headache disorders may benefit from comprehensive headache treatment plans that include abortive therapy, prophylactic therapy, and non-pharmacological modalities. Although there is limited data in adults, those with SCD are at risk for medication overuse headache secondary to ...



Acute Primary Hematogenous Osteomyelitis in the Epiphysis of the Distal Tibia: A Case Report With Review of the Literature

Sun, 14 Feb 2016 00:00:00 +0100

We report the case of a 12-year-old male with epiphyseal osteomyelitis that had developed in the distal tibia. To the best of our knowledge, this is the first published case report. The patient's history of a trauma that resembled an ankle sprain had delayed the diagnosis and subsequently led him to develop septic arthritis. The ankle is a common site of simple trauma; however, epiphyseal osteomyelitis is rare at this site. Therefore, if the symptoms continue or worsen after trauma, the clinician should check the affected site and take a more aggressive approach to make an early diagnosis. (Source: The Journal of Foot and Ankle Surgery)



Surgical Debridement Is Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model

Fri, 12 Feb 2016 00:00:00 +0100

Discussion Thus, the animal model presented herein provides a reliable and fascinating tool to study posttraumatic osteomyelitis for clinical therapies. (Source: PLoS One)

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Scintigraphic Evaluation of the Stump Region After Extremity Amputation and the Effect of Scintigraphy on Treatment.

Thu, 11 Feb 2016 08:15:03 +0100

CONCLUSION: Bone scintigraphy is a cost-effective, non-invasive, and efficient method that directs treatment in the evaluation of the stump region after amputation. PMID: 26858796 [PubMed] (Source: Clin Med Res)



Management of Orthopedic InfectionsManagement of Orthopedic Infections

Wed, 10 Feb 2016 05:14:00 +0100

Septic arthritis, prosthetic joint infections, and osteomyelitis are increasing in prevalence. Read how to effectively manage these challenging orthopedic infections. Journal for Nurse Practitioners (Source: Medscape Orthopaedics Headlines)



[Carbapenem-resistant Acinetobacter baumannii causing osteomyelitis and infections of skin and soft tissues in hospitals of Medellín, Colombia].

Tue, 09 Feb 2016 02:05:02 +0100

CONCLUSION: In contrast to previous reports, the results of the present study showed osteomyelitis and infections of skin and soft tissues to be the main infections caused by carbapenem-resistant A. baumannii in Medellín hospitals and revealed its importance as an etiological agent for this type of infections. PMID: 26844441 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)



[Osteomyelitis due to Yokenella regensburgei following craniotomy in an immunocompetent patient].

Tue, 09 Feb 2016 02:05:02 +0100

We report the first case of post-surgical secondary osteomyelitis due to Y. regensburgei in an immunocompetent woman who had undergone a craniotomy. PMID: 26844435 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)

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The Use of C-reactive Protein as a Guide for Transitioning to Oral Antibiotics in Pediatric Osteoarticular Infections

Fri, 05 Feb 2016 16:19:33 +0100

Conclusions: We found that the combination of clinical improvement and a specific reduction of 50% in CRP levels over 4 days, or 5 CRP half lives, could be used to determine when to transition children with osteoarticular infections from parenteral to oral therapy. Complicated outcomes were associated with negative cultures, longer hospitalizations, and persistently elevated CRP levels. Level of Evidence: Level IV—Case Series (Source: Journal of Pediatric Orthopaedics)



Knockdown of TNFR1 Suppresses Expression of TLR2 in the Cellular Response to Staphylococcus aureus Infection

Fri, 05 Feb 2016 00:00:00 +0100

Abstract Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection characterized by widespread bone loss and destruction. Phagocytes possess various receptors to detect pathogens, including the Toll-like receptors (TLRs). Previous studies have demonstrated that the S. aureus protein SpA binds directly to pre-osteoblastic cells via tumor necrosis factor receptor-1 (TNFR-1). In our present study, we investigated the relationship between TLR2 and TNFR-1 in S. aureus-infected osteoblasts. Our results showed that cell viability decreased, and apoptosis, expression of TLR2, and the secretion of inflammatory cytokines (TNF-α and IL-6) increased with increasing concentrations of S. aureus. The JNK pathway was also activated in response to S. aureus infection. Kn...



Pre-packing of cost effective antibiotic cement beads for the treatment of traumatic osteomyelitis in the developing world–an in-vitro study based in Cambodia

Fri, 05 Feb 2016 00:00:00 +0100

This study is based in Cambodia, a low income country struggling to recover from a recent genocide. The study aims to test the effectiveness of locally made antibiotic beads and analyse their effectiveness after being gas sterilised, packaged and kept in storageDifferent antibiotic beads were manufactured locally using bone cement and tested against MRSA bacteria grown from a case of osteomyelitis. (Source: Injury)



Charcot spinal arthropathy after spinal cord injury

Thu, 04 Feb 2016 00:00:00 +0100

57 year-old paraplegic male with history significant for multiple urogenital infections and MRSA bacteremia presented with Charcot spinal arthropathy. In 2013, he presented with T9-12 osteomyelitis, a T11 burst fracture, and complete dissociation below a previous fusion at the thoracolumbar junction. This required removal of the prior instrumentation from T5-T11, a T11 corpectomy, T7-L3 instrumented arthrodesis. A mesh cage was placed at T10-11 and a 10 cm-diameter intraspinal synovial cyst was removed. (Source: The Spine Journal)



Thoracolumbar Scoliosis Due to Cryptococcal Osteomyelitis: A Case Report and Review of the Literature

Mon, 01 Feb 2016 06:00:00 +0100

This study is to present a case of thoracolumbar scoliosis occurring in the setting of cryptococcal osteomyelitis. Pharmacological intervention with anticryptococcal medicine and medical management of immune hemolytic anemia were administered. After initial acute stabilization, she underwent spinal debridement and fusion on October 29, 2008. She eventually recovered fully from this episode with no subsequent mechanical instability or neurological deficits on subsequent clinic follow-ups. To the best of our knowledge, there have been no reports describing the onset of spinal cryptococcal osteomyelitis along with immune hemolytic anemia. We suggest a comprehensive algorithm for the diagnosis of vertebral cryptococcal osteomyelitis. (Source: Medicine)

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Neurologic Complications, Reoperation, and Clinical Outcomes After Surgery for Vertebral Osteomyelitis

Mon, 01 Feb 2016 06:00:00 +0100

Study Design. A consecutive retrospective cohort study from 2008 to 2013 at a single tertiary-care institution was conducted. Objective. The aim of the study was to characterize recovery from pain and neurologic deficit after surgery for vertebral osteomyelitis (VO), and identify incidence of postoperative adverse events. Summary of Background Data. A minority of patients with VO require surgery. Although prior studies have characterized outcomes after medical management, the morbidity after surgery is poorly defined. Methods. The primary outcome was change from baseline in a Modified McCormick Scale (MMS, 1–5 scale), whereas secondary outcomes included reoperation and change in self-reported pain Visual Analog Scale (VAS, 0–10 scale). MMS and VAS were collected throughout the posto...



A Retrospective Case-Series of Children With Bone and Joint Infection From Northern Australia

Mon, 01 Feb 2016 06:00:00 +0100

We report 3 key findings: osteomyelitis incidence in indigenous children of northern Australia is amongst the highest reported in the world; methicillin-resistant S aureus accounts for 36% of osteomyelitis with a positive microbiological diagnosis; and the severity of disease requires extended antibiotic therapy. Despite this, 15% of the cohort relapsed within 12 months and required readmission. (Source: Medicine)



Oritavancin: A New Lipoglycopeptide Antibiotic in the Treatment of Gram-Positive Infections

Mon, 01 Feb 2016 00:00:00 +0100

Abstract Resistance among Gram-positive organisms has been steadily increasing over the last several years; however, the development of new antibiotics to treat infections caused from these organisms has fallen short of the emergent need. Specifically, resistance among Staphylococcus aureus and Enterococcus spp. to essential antibiotics is considered a major problem. Oritavancin is a semisynthetic lipoglycopeptide antibiotic that was recently approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI). While structurally related to vancomycin, oritavancin also possesses unique mechanisms of action that greatly enhance its antimicrobial potency against multi-drug resistant pathogens including both VanA- and VanB-mediated vancomycin-resistant enterococc...



Mycotic Aneurysm Due to Lecleria Adecarboxylata: A Complication of Vertebral Osteomyelitis

Mon, 01 Feb 2016 00:00:00 +0100

We present the case of a male who presented with limb vein thrombosis, fatigue and a history of back pain. The computed tomography scan revealed a saccular aneurysm and combined vertebral osteomyelitis of the 3rd lumbar vertebra. (Source: Annals of Vascular Surgery)



Poly(trimethylene carbonate) as a carrier for rifampicin and vancomycin to target therapy‐recalcitrant staphylococcal biofilms

Mon, 01 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Orthopaedic Research)

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Mycotic Aneurysm Due to : A Complication of Vertebral Osteomyelitis

Mon, 01 Feb 2016 00:00:00 +0100

We present the case of a male who presented with limb vein thrombosis, fatigue, and a history of back pain. The computed tomography scan revealed a saccular aneurysm and combined vertebral osteomyelitis of the third lumbar vertebra. (Source: Annals of Vascular Surgery)



Mycotic Aneurysm Due to Leclercia Adecarboxylata: A Complication of Vertebral Osteomyelitis

Mon, 01 Feb 2016 00:00:00 +0100

We present the case of a male who presented with limb vein thrombosis, fatigue, and a history of back pain. The computed tomography scan revealed a saccular aneurysm and combined vertebral osteomyelitis of the third lumbar vertebra. (Source: Annals of Vascular Surgery)



Chronic Osteomyelitis of the Manubrio-Clavicular Joint following Breast Augmentation

Sat, 30 Jan 2016 04:34:41 +0100

No abstract available (Source: Plastic and Reconstructive Surgery)



Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis

Sat, 30 Jan 2016 04:34:40 +0100

Conclusions: The results suggest that early cranioplasty is a viable treatment option for patients with previous bone flap osteomyelitis and subsequent removal. As such, a reduced time interval of 3 months—with equivalent outcomes and reinfection rates—represents a promising area for future study aiming to reduce the morbidity surrounding prolonged time intervals. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. (Source: Plastic and Reconstructive Surgery)



Mild-to-moderate hyperglycemia will not decrease the sensitivity of 18F-FDG PET imaging in the detection of pedal osteomyelitis in diabetic patients

Sat, 30 Jan 2016 02:04:04 +0100

Conclusion: Mildly to moderately elevated serum glucose levels do not adversely affect the accuracy of 18F-FDG PET imaging in the detection of pedal osteomyelitis in diabetic patients. (Source: Nuclear Medicine Communications)

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Delivery of Antifungal Agents from Bone Cement

Sat, 30 Jan 2016 00:00:00 +0100

This article provides an overview of bone cement as a delivery system for antifungal agents in vitro and in clinical reports. (Source: Current Fungal Infection Reports)



Juvenile Mandibular Chronic Osteomyelitis: Role of Surgical Debridement and Antibiotics

Fri, 29 Jan 2016 00:00:00 +0100

To document outcomes of management of juvenile mandibular chronic osteomyelitis (JMCO) using a standardized treatment protocol including open biopsy, decortication, microbial culture and long-term antibiotic therapy. (Source: Journal of Oral and Maxillofacial Surgery)



Pneumocephalus associated with Pott's puffy tumor

Wed, 27 Jan 2016 00:00:00 +0100

Pott's puffy tumor is a subperiosteal abscess of the frontal bone associated with osteomyelitis, and appears as a localized swelling of the overlying region of the forehead. Pott's puffy tumor is a relatively rare entity in the era of antibiotic therapy, although it can lead to life-threatening intracranial complications such as epidural or subdural abscess, meningitis, and venous sinus thrombosis, particularly in misdiagnosed or inappropriately treated cases [1,2]. Pneumocephalus defined as the presence of air or gas in the cranial cavity, is also rare and is usually caused by trauma, neoplasm, infection, or surgical intervention [3]. (Source: Journal of the Neurological Sciences)



Treatment of Chronic Bone Infections

Tue, 26 Jan 2016 00:00:00 +0100

The treatment of chronic osteomyelitis (COM) depends on the obstinate persistence of the offending microorganism(s), and can result in long-term patient disability that increases costs to the health care system. Difficulties of treating COM derive from biofilm-forming pathogens that resist the host immunological defense and other antimicrobial substances, and the need to treat osseous defects that result from the disease itself. Established surgical techniques require multiple costly operations with extended periods of disablement and impairment of the patients, sometimes making the therapy worse than the disease. (Source: Operative Techniques in Orthopaedics)



Treatment of Chronic Bone Infection

Tue, 26 Jan 2016 00:00:00 +0100

The treatment of chronic osteomyelitis depends on the obstinate persistence of the offending micro-organism(s) and often results in long-term patient disability causing remarkable costs to the health care system. Difficulties of treating chronic osteomyelitis derive from biofilm-forming pathogens that resist the host immunologic defense and antimicrobial substances, and the need to treat osseous defects that result from the disease itself and eventual previous interventions. Established surgical techniques require multiple costly operations with extended periods of disablement and impairment of the patients, sometimes making the therapy worse than the disease. (Source: Operative Techniques in Orthopaedics)

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Possible association between mandibular repositioning device for sleep apnea and osseous lytic lesion with fracture of the coronoid process of the mandible: A case report

Mon, 25 Jan 2016 14:21:40 +0100

Agbaje, Jimoh Olubanwo / Salem, Ahmed S. / Lambrichts, Ivo / Braem, Marc / Politis, ConstantinusPage 141 - 145Mandibular repositioning devices (MRDs) increase the patency of the upper airway by repositioning the mandible forward, resulting in displacement of the oropharyngeal tissues preventing upper airway collapsibility. Mandibular anterior repositioning is counteracted by muscle force from the temporalis muscle. A 39-year-old man had an osteolytic lesion with fracture of the coronoid process of the mandible secondary to wearing a MRD for sleep apnea. Continuous stress generated on the coronoid process temporalis muscle resulted in osteolysis and fracture of the coronoid process on the patient's right side, resulting in swelling and limited ability to open his mouth. The patient was mana...