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MedWorm: Orthopaedics



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Orthopaedics



Last Build Date: Mon, 28 Mar 2016 00:14:49 +0100

 



Exposure to hand-arm vibrations in orthopaedic plaster room: risk management.

Sun, 27 Mar 2016 15:04:02 +0100

CONCLUSIONS: The values of acceleration and noise detected on the instruments  were  in line with those reported in the literature. The preventive measure adopted (replacing plaster saws currently used in the hospital with similar ones with lower vibration emission) was an adequate means of protection. Health surveillance activities  recorded a higher level of wellbeing, both environmentally and individually and, specifically, an increased protection level for the hyper-susceptibility conditions observed during health checks of exposed personnel  which will be monitored regularly by the Occupational Health Service. PMID: 27015026 [PubMed - as supplied by publisher] (Source: Medicina del Lavoro)

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Non-adherence with bisphosphonates among patients with osteoporosis: impact on fracture risk and healthcare cost‏.

Sun, 27 Mar 2016 03:55:02 +0100

Authors: Chodick G, Moser SS, Goldshtein I Abstract Osteoporosis-related fractures at the spine and hip have a substantial impact on mortality, morbidity, and quality of life in older adults worldwide. Adherence to bisphosphonates is essential for effective treatment and fracture prevention. Nevertheless, numerous studies from various populations and study designs clearly indicated that adherence and persistence are poor with more than 50% of patients discontinuing therapy within one year. This is primarily explained by mild adverse effects, dosing regimens, and costs. Studies have also shown that good adherence is associated with reduced osteoporosis-related and non-related healthcare costs as soon as 2 years from therapy initiation. Nonetheless, we found only little improvement i...



Mayo Clinic Hand and Orthopaedic Surgery Research Fellowship

Sat, 26 Mar 2016 23:49:40 +0100

I am excited to offer a mentored 1 year research fellowship within Hand and Orthopaedic Surgery at Mayo Clinic, Rochester, MN. This position will offer a one on one research fellowship where you will be exposed to exciting and cutting edge research. The goal is to increase your knowledge and exposure within in Orthopaedic Surgery, resulting in presentations at National and International meetings as well as publications within numerous peer reviewed journals. This will strengthen your academic CV with several fellows in the past matching into their desired programs.  (Source: Orthogate - Latest News)



Mayo Clinic Orthopaedic Surgery Research Fellowship

Sat, 26 Mar 2016 23:49:40 +0100

I am excited to offer a mentored 1 year research fellowship within Hand and Orthopaedic Surgery at Mayo Clinic, Rochester, MN. This position will offer a one on one research fellowship where you will be exposed to exciting and cutting edge research. The goal is to increase your knowledge and exposure within Orthopaedic Surgery and present at National and International meetings as well as publish within peer reviewed journals and strengthen your academic CV. (Source: Orthogate - Latest News)



Microvascular medial femoral condylar flaps in 107 consecutive reconstructions in the head and neck

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): Christian Brandtner, Johannes Hachleitner, Gian Battista Bottini, Heinz Buerger, Alexander Gaggl We have assessed the role of the medial femoral condylar flap in 107 patients who had reconstructions of the head and neck. We retrospectively reviewed their medical records for indications, complications, and outcomes. The flap was primarily used for coverage of alveolar ridge defects (n=67), secondly for defects of the facial bone, calvaria, or skull base (n=35), and thirdly for partial laryngeal defects (n=5). Two flaps were lost. One patient fractured a femur 5 weeks postoperatively. The duration of follow up ranged from 6 months to 12 years. The medial femoral condyla...



The effect of low-intensity pulsed ultrasound on wound healing using scratch assay in epithelial cells

Sat, 26 Mar 2016 23:00:00 +0100

Conclusion LIPUS exposure promotes wound closure in the scratch assay and up-regulates the expression level of integrin α6β4 as compared with the control. (Source: Journal of Prosthodontic Research)



A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery after surgery (ERAS) total knee replacement

Sat, 26 Mar 2016 23:00:00 +0100

Conclusions TXA reduced significantly the blood loss and the need for transfusion in ERAS primary unilateral TKR. (Source: Journal of Orthopaedics)



Reconstructive osteotomy for a malunited medial Hoffa fracture – A feasible salvage option

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: September 2016 Source:Journal of Orthopaedics, Volume 13, Issue 3 Author(s): Binu Sasidharan, Surendra Shetty, Satheesh Philip, Shivanand Shetty A 35-year-old male presented with pain and restriction of movements of right knee of 9 months duration. He underwent open reduction and internal fixation for a coronal plane fracture of medial femoral condyle (Hoffa fracture) in another facility 9 months back. Radiological evaluation showed a malunited isolated medial Hoffa fracture. We did an intraarticular osteotomy as a salvage treatment and got a reasonable outcome. This case report analyses the difficulties in the management of this inherently unstable fracture pattern and the technique of intraarticular osteotomy. (Source: Journal of Orthopaedics)

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Liposclerosing myxofibrous tumor: A series of 9 cases and review of the literature

Sat, 26 Mar 2016 23:00:00 +0100

Conclusions These features suggest that the lesion may represent a variant of fibrous dysplasia with a high risk of malignant transformation. (Source: Journal of Orthopaedics)



Comparison of the palatal expansion obtained via the use of the rapid maxillary expander compared with surgically assisted rapid maxillary expansion.

Sat, 26 Mar 2016 17:00:02 +0100

CONCLUSIONS: Rapid maxillary expander and surgically assisted rapid maxillary expansion SARME can be used for the resolution of malocclusions characterized by a transverse maxillary hypoplasia. The choice between RME and SARME is linked to the age of the patient, and the biological stage of the maxillary suture. PMID: 27009412 [PubMed - in process] (Source: Minerva Stomatologica)



Impact Forces of Walking and Running at the Same Intensity

Sat, 26 Mar 2016 10:25:17 +0100

Abstract: Swain, DP, Kelleran, KJ, Graves, MS, and Morrison, S. Impact forces of walking and running at the same intensity. J Strength Cond Res 30(4): 1042–1049, 2016—Moderate-intensity walking (horizontal, WH), vigorous-intensity walking (incline, WI), and vigorous-intensity running (horizontal, R) were compared. The hypothesis is that running creates greater loading forces than walking even at the same aerobic intensity. Young adults (10 M and 10 F; age, 22.8 ± 0.5 years) performed 3 exercise trials in a counter-balanced order: walking 5.5 kph at 0% grade (WH); walking 5.5 kph at 11% (WI); and running at 8.0 kph at 0% (R). Oxygen consumption (V[Combining Dot Above]O2), step frequency, peak vertical ground reaction force (VGRF), and vertical force loading rate were recorded during th...

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New Magnetic Resonance Imaging Features Predictive for Post-Treatment Ambulatory Function: Imaging Analysis of Metastatic Spinal Cord Compression

Sat, 26 Mar 2016 08:25:25 +0100

Conclusion. CRCC on axial T2 image can guide clinicians to identify cancer patients at risk of paraplegia because of MSCC. More than half of CRCC entails urgent treatment despite preserved ambulatory function. Furthermore, some cases of MSCC accompany increased cord CSA. The measurement is also a useful guide to balance the risk and benefit of systemic steroid therapy. MRI is the key imaging modality in the risk assessment of MSCC. Level of Evidence: 4 (Source: Spine)



Evaluation of Water Retention in Lumbar Intervertebral Disks Before and After Exercise Stress With T2 Mapping

Sat, 26 Mar 2016 08:25:25 +0100

Conclusion. T2 mapping could be used to not only diagnose the degree of degeneration but also evaluate intervertebral disk function. Level of Evidence: 3 (Source: Spine)



Cost Effectiveness of Operative Versus Non-Operative Treatment of Geriatric Type-II Odontoid Fracture

Sat, 26 Mar 2016 08:25:25 +0100

Conclusion. Operative treatment is cost-effective in patients age 65 to 84 when using $100,000/QALY as a benchmark but less effective and more costly than non-operative treatment in patients older than 84 years. Level of Evidence: 2 (Source: Spine)



A Subtle Threat to Urban Populations in Developing Countries: Low Back Pain and its Related Risk Factors

Sat, 26 Mar 2016 08:25:25 +0100

Conclusion. LBP is prevalent among the general population of Tehran. Our findings can help health care providers regarding logical assignment of limited resources, in order to create multidimensional prevention plans according to potentially modifiable associated factors. Level of Evidence: 3 (Source: Spine)



Proposed Scoring System for Evaluating Neurologic Deficit after Sacral Resection: Functional Outcomes of 170 Consecutive Patients

Sat, 26 Mar 2016 08:25:25 +0100

Study Design. Cross-section analysis. Objective. A quality-of-life oriented scoring system for evaluation of lower limbs, bladder, and bowel functions of patients after sacral tumor resection has been proposed and was adopted in a clinical research. Summary of Background Data. Surgical resections of sacral tumors usually cause postoperative neurologic deficits. A widely agreed scoring system for detailed evaluation of functional outcomes is not yet established. Methods. The scoring system has three domains with three items in each domain, being allocated 0 to 3 points of each item according to the degree of functional impairment. Overall function scale is presented in percentage form. In the current single-center cross-section study, it was adopted to evaluate and quantify the postopera...

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Evaluation of Scoring Systems and Prognostic Factors in Patients With Spinal Metastases From Lung Cancer

Sat, 26 Mar 2016 08:25:25 +0100

Conclusion. Although better prognostic scores correlated with longer survival, all four scoring systems are inaccurate in prognosticating patients with lung cancer spinal metastases. Specific lung cancer histology appears prognostic and should be considered, especially given the increased survival of patients receiving new targeted therapies appropriate to their disease. Level of Evidence: 3 (Source: Spine)



Worsening Cervical Epidural Hematoma After Tissue Plasminogen Activator Administration for Stroke Like Symptoms

Sat, 26 Mar 2016 08:25:25 +0100

Conclusion. To our knowledge, only three cases of cervical SEH with hemiparesis erroneously treated with tPA resulting in neurological decline because of the enlargement of an existing hematoma, including the current case, have been reported in the English literature. It is important for physicians, especially those who administer tPA treatment, to include cervical SEH in the differential diagnosis of stroke in patients presenting with sudden back pain followed by the onset of neurological deficits including hemiparesis. Level of Evidence: 5 (Source: Spine)



Can Dysphagia Following Anterior Cervical Fusions With rhBMP-2 Be Reduced With Local Depomedrol Application?: A Prospective, Randomized, Placebo-Controlled, Double-Blind Trial

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. A prospective, randomized, placebo-controlled, double-blind trial. Objective. The aim of this study was to investigate whether the local administration of depomedrol decreases the severity of dysphagia after anterior cervical discectomy and fusion (ACDF) surgery using bone morphogenetic protein (BMP). Summary of Background Data. Although recombinant human BMP-2 is effective in promoting arthrodesis, many physicians avoid using it in anterior cervical spine fusions due to concern for increased incidence of dysphagia, significant pre-vertebral swelling, and airway compromise. Pilot studies have shown that the local application of depomedrol may decrease the incidence of postoperative dysphagia. We performed a prospective, randomized trial to evaluate the efficacy of local dep...



Can Decision Support Help Patients With Spinal Stenosis Make a Treatment Choice?: A Prospective Study Assessing the Impact of a Patient Decision Aid and Health Coaching

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. A prospective, randomized study on patients with lumbar spinal stenosis who received a decision support intervention to facilitate their treatment choice. Objective. The aim of this study was to assess the impact of telephone health coaching (HC) in addition to a video decision aid (DA) compared with a DA alone for patients with spinal stenosis. Summary of Background Data. Treatment options for lumbar spinal stenosis include surgical and nonsurgical approaches. Patient DAs and HC have been shown to help patients make an informed treatment choice consistent with personal preferences. Methods. Eligible patients with spinal stenosis were identified by an orthopedic surgeon or a nonsurgical spine specialist. Consenting participants were randomly assigned to either a video DA o...



Quantifying Progressive Anterior Overgrowth in the Thoracic Vertebrae of Adolescent Idiopathic Scoliosis Patients: A Sequential Magnetic Resonance Imaging Study

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. Whilst AIS patients have a proportionally longer anterior column than nonscoliotic controls, the degree of anterior overgrowth was not related to the rate of progression or the severity of the scoliotic curve. Level of Evidence: 3 (Source: Spine)



Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. Impairment of different nutrition pathways results in different degenerative patterns. Level of Evidence: N/A (Source: Spine)



Use of Supplemental Short Pre-Contoured Accessory Rods and Cobalt Chrome Alloy Posterior Rods Reduces Primary Rod Strain and Range of Motion Across the Pedicle Subtraction Osteotomy Level: An In Vitro Biomechanical Study

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. In vitro cadaveric biomechanical study. Objective. To assess effects of 4-rod reconstruction, rod material, and anterior column support on motion and surface rod strain in a pedicle subtraction osteotomy model. Summary of Background Data. Pedicle subtraction osteotomy (PSO) can correct significant sagittal deformity of the lumbar spine; however, revision rates are high. To reduce rod strain and the incidence of rod fracture, clinical use of multi-rod construction, cobalt chrome (CoCr) alloy rods, and interbody spacers adjacent to PSO has been proposed. Investigating both motion and rod strain is necessary to determine the biomechanical efficacy of these techniques. Methods. Five specimens (T12–S1) underwent PSO at L3 with pedicle screw stabilization at L1–S1. Pedicle s...



Relationship Between T1 Slope and Cervical Alignment Following Multilevel Posterior Cervical Fusion Surgery: Impact of T1 Slope Minus Cervical Lordosis

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. This study showed that disability of the neck increased with cervical sagittal malalignment following surgical reconstruction and a greater T1S-CL mismatch was associated with a greater degree of cervical malalignment. Specifically, a mismatch greater than 26.1° corresponded to positive cervical sagittal malalignment, defined as C2-C7 SVA greater than 50 mm. Level of Evidence: 3 (Source: Spine)

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Anterior Facetectomy for Reduction of Cervical Facet Dislocation

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. Anterior facetectomy reduction represents a safe and efficacious but technically challenging option for the treatment of cervical facet dislocation. Level of Evidence: 5 (Source: Spine)



The Study of Cobb Angular Velocity in Cervical Spine during Dynamic Extension–Flexion

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. The intervertebral movements of cervical spine did not take a uniform motion form when the cervical spine moved from full-extension to full-flexion. From C2/3 to C6/7, the peak CAV value appeared in order. The C4/5 and C5/6 segments exhibited more complex kinematic characteristics in sagittal movement. This leads to C4/5 and C5/6 more vulnerable to injury and degeneration. We had a hypothesis that there was a positive correlation between injury/degeneration and complexity of intervertebral movement in the view of CAV. Level of Evidence: N/A (Source: Spine)



The Impact of Current Smoking and Smoking Cessation on Short-Term Morbidity Risk After Lumbar Spine Surgery

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. A retrospective review of prospectively collected data. Objective. The aim of this study was to determine the impact of current smoking or prior smoking cessation on 30-day morbidity risk following lumbar spine surgery. Summary of Background Data. Prior studies have reported conflicting data regarding the impact of smoking on morbidity risk, and few studies have investigated smoking cessation. Methods. A large, multicenter, prospectively collected clinical registry was queried for all adult patients undergoing lumbar spine surgery in 2012 and 2013, and 35,477 cases were identified. Morbidity data are collected by on-site clinical personnel for 30 days postoperatively. Patients were divided into categories of “never-smoker,” for patients with no reported cigarette use (...



Comparison of Clinical Outcomes in the National Neurosurgery Quality and Outcomes Database for Open Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. A retrospective database review. Objective. The aim of this study was to compare data on various pain and functional outcomes for patients who underwent minimally invasive transforaminal lumbar interbody fusion (MiTLIF) and those who had open TLIF to better delineate which patients may benefit from each procedure. Summary of Background Data. TLIF is a highly successful technique for the treatment of patients with degenerative instability or deformity. Minimally invasive approaches have been developed in an effort to improve outcomes by reducing tissue trauma and minimizing surgical time and blood loss. Although these approaches have been compared in the literature, there continues to be a debate about which patients may benefit from each procedure, and there is a dearth of ...



The Position of the Aorta Relative to the Vertebrae in Patients With Lenke Type 1 Adolescent Idiopathic Scoliosis

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. The direction error has a potential risk of injuring the aorta around the apical vertebra. The selection of screws of the proper length is necessary to avoid a breach of the anterior vertebral wall at thoracolumbar level, especially at T11. Level of Evidence: 3 (Source: Spine)

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Selection of Lowest Instrumented Vertebra for Thoracolumbar Kyphosis in Ankylosing Spondylitis

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. Retrospective study. Objective. To determine the optimal osteotomized vertebra (OV) and lowest instrumented vertebra (LIV) in ankylosing spondylitis (AS) kyphosis. Summary of Background Data. Although most of AS kyphosis cases are treated by pedicle subtraction osteotomy (PSO), few studies have focused on the selection of the LIV relative to distal OV. Methods. We reviewed all AS kyphosis cases surgically treated at our institution between 2010 and 2013. Patients were divided into groups based on the relative position of LIV and distal OV: group OV+2, the LIV was the second vertebra below OV; group OV+3, the LIV was the third vertebra below OV; group OV+4, the LIV was the fourth vertebra below OV. The preoperative and 2-year postoperative radiographic parameters and clinic...



Morphological Differences in the Vertebrae of Scoliosis Secondary to Neurofibromatosis Type 1 With and Without Paraspinal Neurofibromas

Sat, 26 Mar 2016 08:25:24 +0100

Study Design. A retrospective study. Objective. Aim of the study was to investigate morphological differences in the vertebrae of scoliosis secondary to neurofibromatosis type 1 (NF1-S) with and without paraspinal neurofibromas and to identify the relationship between paraspinal neurofibromas and vertebral deformity. Summary of Background Data. Scoliosis is the most common orthopedic manifestation of NF1. Erosion or infiltration of the bone by localized neurofibromas was suggested as one of the primary etiology for the vertebral deformity. Methods. One hundred fourteen patients with NF1-S were classified into spinal tumor (ST) group and nontumor (NT) group with respect to the presence of paraspinal neurofibromas. The curve pattern, curve magnitude, the shape and location of paraspinal n...



A Multicenter Comparison of Inpatient Resource Use for Adult Spinal Deformity Surgery

Sat, 26 Mar 2016 08:25:24 +0100

Conclusion. The use of additional surgical resources does not appear to impact 2-year HRQoL outcomes after surgery for ASD. The estimated impact of physician preference on surgical resource utilization highlights the variation in current surgical practice and the opportunity for cost reductions via a more standardized approach. Level of Evidence: 3 (Source: Spine)



Baxter's syndrome

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 25 March 2016 Source:Joint Bone Spine Author(s): Dominique Lechevalier, Lisa Bialé, Camille Glanowski, Isabelle Imbert, Evelyne Péroux, Frédéric Banal (Source: Joint Bone Spine)

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Patient-reported factors influencing return to work after joint replacement

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Return to work is influenced by a combination of patient, clinician and occupational factors. The relationship between each of these needs to be explored in greater depth through further qualitative work to gain a wider understanding of the variables influencing patients’ RTW following hip and knee replacement. (Source: Occupational Medicine)



Intraoperative application of hand-held structured light scanning: a feasibility study

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The results of this preliminary study indicate that structured light scanning could be applied accurately and safely in a surgical environment. This could result in a variety of applications for these scanners in image-guided interventions as intraoperative imaging and registration tools. (Source: International Journal of Computer Assisted Radiology and Surgery)



Evaluation of Ag containing hydroxyapatite coatings to the Candida albicans infection

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Journal of Microbiological Methods Author(s): S. Ciuca, M. Badea, E. Pozna, I. Pana, A. Kiss, L. Floroian, A. Semenescu, C.M. Cotrut, M. Moga, A. Vladescu In this research work, the synthesis of Ag doped hydroxyapatite coatings for dental or orthopedic implants was performed. The main goal was to determine the influence of Ag content on the roughness and antimicrobial performance of the prepared thin films. The films were deposited on Ti6Al4V alloy by means of RF magnetron sputtering. Those coatings were characterized by X-ray diffraction (XRD) and 3D surface profilometry. The antifungal activity after 1 and 7days of culture was evaluated in the presence of Candida albicans (ATCC — 10231). The increase of Ag content incr...



Simply the best

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Rolf G. Behrents (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Linking orthodontic treatment and caries management for high-risk adolescents

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Claudia L. Cruz, Burton L. Edelstein (Source: American Journal of Orthodontics and Dentofacial Orthopedics)

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Bone and cartilage changes after injection of botulinum toxin

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Scott Frey (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



One hundred years of orthodontic history

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Roozbeh Khosravi (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Corticotomy-assisted rapid maxillary expansion

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Priyank Rai, Tulika Tripathi, Shilpa Kalra, Anup Kanase, Neha Khanna, Navneet Singh (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Would you do it again?

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Peter M. Greco (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Surgery first in orthognathic surgery: A systematic review of the literature

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The surgery-first approach is a new treatment paradigm for the management of dentomaxillofacial deformity. Studies have reported satisfactory outcomes and high acceptance. However, the results should be interpreted with caution because of the wide varieties of study designs and outcome variables, reporting biases, and lack of prospective long-term follow-ups. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)

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Periodontal status after surgical-orthodontic treatment of labially impacted canines with different surgical techniques: A systematic review

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The current literature is insufficient to determine which surgical procedure is better for periodontal health for uncovering labially impacted canines. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Evaluation of corticotomy-facilitated orthodontics and piezocision in rapid canine retraction

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Corticotomy-facilitated orthodontics and piezocision are efficient treatment modalities for accelerating canine retraction. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Posttreatment evaluation of maxillary canine positions in 15-year-old subjects

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The maxillary canine position in relation to skeletal landmarks was determined and does not appear to significantly impact the esthetic perception, according to this study. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Orthodontic pain trajectories in adolescents: Between-subject and within-subject variability in pain perception

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The 12- to 15-year-old boys reported the lowest mean average pain intensity and a minimum subjective variation in between-subject and within-subject variances. The 15- to 18-year-old girls experienced maximum mean pain intensity and the highest daily fluctuations in pain intensity. The 12- to 15-year-old girls were the most different from one another in their overall pain experience. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Facial surface morphology predicts variation in internal skeletal shape

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Surface morphology is a reliable source of proxy data for the characterization of skeletal shape variation and thus is particularly valuable in research designs where reducing potential long-term risks associated with radiologic imaging methods is warranted. We propose that longitudinal surface morphology from early childhood through late adolescence can be a valuable source of data that will facilitate the development of personalized craniodental and treatment plans and reduce exposure levels to as low as reasonably achievable. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)

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Utility of panoramic radiography for identification of the pubertal growth period

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions An association exists between the dental mineralization stages and the periods of the PGS, especially for second molars. Panoramic radiographs can be used as the first diagnostic tool to estimate the pubertal growth period. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Racial disparities in orthodontic service use for Medicaid-enrolled children: An evaluation of the Washington Medicaid program

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions In 2012, nonwhite children in the Washington Medicaid program were significantly more likely to use orthodontic care than were white children. The Washington Medicaid program demonstrates a potential model for addressing racial disparities in orthodontic service use. Future research should identify mechanisms underlying these findings and continue to monitor orthodontic service use for minority children in Medicaid. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions BoneCeramic has better osteoconductive potential and induces less root resorption compared with Bio-Oss grafting and naturally recovered extraction sites. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Comparison and reproducibility of 2 regions of reference for maxillary regional registration with cone-beam computed tomography

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The 2 regions of regional maxillary registration showed similar results and adequate intraobserver and interobserver reproducibility values. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Objective vs subjective analyses of arch form and preformed archwire selection

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The objective method improved wire adaptation to the clinical bracket points. Agreement among orthodontists regarding wire selection will improve significantly when they are trained to use the software. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)

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Diagnosis and conservative treatment of skeletal Class III malocclusion with anterior crossbite and asymmetric maxillary crowding

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Linda L.Y. Tseng, Chris H. Chang, W. Eugene Roberts A man, aged 28 years 9 months, came for an orthodontic consultation for a skeletal Class III malocclusion (ANB angle, −3°) with a modest asymmetric Class II and Class III molar relationship, complicated by an anterior crossbite, a deepbite, and 12 mm of asymmetric maxillary crowding. Despite the severity of the malocclusion (Discrepancy Index, 37), the patient desired noninvasive camouflage treatment. The 3-Ring diagnosis showed that treatment without extractions or orthognathic surgery was a viable approach. Arch length analysis indicated that differential interproximal enamel reduction could resolv...



User acceptance of a touchless sterile system to control virtual orthodontic study models

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions This study supports the adoption of this promising development for a sterile touch-free patient record-management system. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Leaving something behind

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Laurance Jerrold (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Multiple linear regression analysis

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Nikolaos Pandis (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



April 2016:149(4)

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Allen H. Moffitt (Source: American Journal of Orthodontics and Dentofacial Orthopedics)

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Cone beam computed tomography in orthodontics: Indications, insights, and innovations

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): Ahmad Abdelkarim (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



William Joseph Thompson, 1932-2015

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: April 2016 Source:American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 4 Author(s): James L. Vaden, Russell P. Greer (Source: American Journal of Orthodontics and Dentofacial Orthopedics)



Microvascular medial femoral condylar flaps in 107 consecutive reconstructions in the head and neck

Fri, 25 Mar 2016 23:00:00 +0100

We have assessed the role of the medial femoral condylar flap in 107 patients who had reconstructions of the head and neck. We retrospectively reviewed their medical records for indications, complications, and outcomes. The flap was primarily used for coverage of alveolar ridge defects (n=67), secondly for defects of the facial bone, calvaria, or skull base (n=35), and thirdly for partial laryngeal defects (n=5). Two flaps were lost. One patient fractured a femur 5 weeks postoperatively. The duration of follow up ranged from 6 months to 12 years. (Source: The British Journal of Oral and Maxillofacial Surgery)



Comparison of the impact of closing wedge versus opening wedge high tibial osteotomy on proximal tibial deformity and subsequent revision to total knee arthroplasty

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion The difference in the post-operative angular deformities of the proximal tibia between CW-HTO and OW-HTO was considered to be clinically irrelevant. The risk of interference between TKA tibial implant and endosteal bone was greater after CW-HTO than after OW-HTO. For clinical relevance, the difference between the two techniques has little influence on subsequent TKA difficulty regarding the proximal tibial deformity, although preoperative planning is obligatory, particularly after CW-HTO, to prevent interference with the tibial implant. Level of evidence II. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)



The medial border of the tibial tuberosity as an auxiliary tool for tibial component rotational alignment during total knee arthroplasty (TKA)

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion This study found that in 90 % of the patients, the medial border of the tibial tuberosity is internally rotated 17°–24° in relation to the line connecting the middle of the tuberosity to the tibial geometric centre. Since this anatomical landmark may be more easily identifiable intraoperatively than the commonly used “medial 1/3”, it can provide a better quantitative reference point and help surgeons achieve a more accurate tibial implant rotational position. Level of evidence Cohort and case control studies, Level III. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)

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Lateral unicompartmental knee replacement for the treatment of arthritis progression after medial unicompartmental replacement

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions These results suggest that addition of a lateral UKA for arthritis progression following medial UKA is a good option in appropriately selected patients. Level of evidence Observational study without controls, Level IV. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)



Identification of the superficial peroneal nerve

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion Since in nearly six out of the ten ankles the superficial peroneal nerve can be identified, it is advised to assess its anatomy prior to portal placement. A higher BMI negatively influences the identification of the superficial peroneal nerve. Level of evidence Diagnostic study, Level III. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)



Total knee arthroplasty in patients with Charcot joints

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions TKA using constrained condylar or rotating hinge prostheses and autografts for massive bone defects is effective for Charcot knees in the reconstruction or coalescence stage. Level of evidence IV. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)



Robotic-assisted total knee arthroplasty may lead to improvement in quality-of-life measures: a 2-year follow-up of a prospective randomized trial

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion Subtle improvements in patient QoL measures were observed in robotic-assisted TKA when compared to conventional TKA. This finding suggests that QoL measures may be more sensitive and clinically important than surgeon-driven objective scores in detecting subtle functional improvements in robotic-assisted TKA patients. Level of evidence II. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)



Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children

Fri, 25 Mar 2016 23:00:00 +0100

Abstract The fibroblast growth factor (FGF) 23/Klotho axis is a principal regulator of phosphate hemostasis and vitamin D metabolism, but limited data is available on its role in the central nervous system. Here, we investigate soluble α-Klotho (sKlotho) and C-terminal as well as intact FGF23 in cerebrospinal fluid (CSF) and plasma and their relationship to mineral metabolism parameters in humans. In 39 children aged 0.3–16.8 years undergoing lumbar puncture for the exclusion of inflammatory neurological disease, sKlotho and FGF23 were investigated by Western blot analysis, followed by ELISA quantification in CSF and plasma. The percentage of intrathecal synthesis of both proteins was calculated by measuring both the expected and observed CSF/plasma ratios of sKlotho and FGF23...

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Propionibacterium prosthetic joint infection: experience from a retrospective database analysis

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion Patients with persistent postoperative pain and/or loosening of implants should be screened for PJI with low-virulent organisms such as Propionibacterium, including. (Source: European Journal of Orthopaedic Surgery and Traumatology)



High tibial osteotomy for the treatment of medial osteoarthritis of the knee with new iBalance system: 2 years of follow-up

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions iBalance proved to be effective and safe and produced good overall results. Consolidation and osseointegration of the system took place rapidly, while recovery was precocious, comparable with traditional methods and with no severe complications. Level of evidence Case series, Level IV. (Source: European Journal of Orthopaedic Surgery and Traumatology)



The gait standard deviation, a single measure of kinematic variability

Fri, 25 Mar 2016 23:00:00 +0100

Clinical gait analysis tends to focus on the shape of the kinematic and kinetic waveforms during a walking stride (e.g. [1]). However, variability of the gait pattern may provide additional, relevant, information about a condition or pre-post an intervention [2]. Mathematical tools to report the variability in kinematic, kinetic or electromyographic (EMG) data exist but there is no tool to summarise overall gait kinematic variability. The aim of this study was to propose and validate such a tool. (Source: Gait and Posture)

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The impact of walking devices on kinematics in patients with spastic bilateral cerebral palsy

Fri, 25 Mar 2016 23:00:00 +0100

Increased anterior pelvic and trunk tilt is a common finding in patients with bilateral cerebral palsy especially during walking with assistive devices as can be monitored by simple video observation. When assessing the gait pattern of these patients for treatment planning it turns out that a significant number of them prefer to use assistive devices even though physically they are able to undergo instrumented 3D gait analysis without assistive devices. Hence, according to the gross motor function classification system (GMFCS) [1] these patients may be either classified into level III as being dependent on assistive devices or into level II as being able to manage without. (Source: Gait and Posture)



Tranexamic Acid Can Be Administered to Arthroplasty Patients Who Receive Aspirin for Venous Thromboembolic Prophylaxis

Fri, 25 Mar 2016 23:00:00 +0100

Venous thromboembolism (VTE) is not uncommon after total joint arthroplasty (TJA). Various prophylactic agents have been used to minimize this complication after TJA. Numerous studies have demonstrated that acetylsalicylic acid (ASA) has equivalent efficacy to other agents in preventing VTE after TJA. However, some have expressed theoretical concern that ASA may not be an adequate VTE prophylaxis in TJA patients receiving tranexamic acid (TA), which is an antifibrinolytic agent. The purpose of the study was to assess the safety and efficacy of administering systemic TA in TJA patients who also received ASA for VTE prophylaxis. (Source: The Journal of Arthroplasty)



Proposal of a therapeutic protocol for selected patients with patellofemoral knee osteoarthritis: arthroscopic lateral retinacular release followed by viscosupplementation

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Arthroscopic lateral retinacular release followed by viscosupplementation is an effective treatment protocol for PFO, simple and minimally invasive with respect to other therapeutic options. (Source: Musculoskeletal Surgery)



Continuous intraarticular and periarticular levobupivacaine for management of pain relief after total knee arthroplasty: A prospective randomized, double-blind pilot study

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion The use of a mix of levobupivacaina, ketoral-trometamina, and adrenalin provides a safe and effective means in post-operative pain relief in patients undergoing TKA. Level of evidence Level II therapeutic study. (Source: Journal of Orthopaedics)



Clinical outcome of anterior vs posterior approach for cervical spondylotic myelopathy

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Posterior decompression resulted in better functional outcomes (p <0.05). (Source: Journal of Orthopaedics)



Preparation and characterization of PVA-PEEK/PVA-β-TCP bilayered hydrogels for articular cartilage tissue repair

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: 18 May 2016 Source:Composites Science and Technology, Volume 128 Author(s): Weichang Li, Junpei Kang, Yulin Yuan, Fengcai Xiao, Hang Yao, Sa Liu, Jianxi Lu, Yingjun Wang, Zhen Wang, Li Ren The poly(vinyl alcohol) (PVA) hydrogel is regarded as a potential articular cartilage replacement for its good biocompatibility, high permeability to fluid and load-bearing properties. This work investigated a novel Poly(vinyl alcohol)-polyetheretherketone/Poly(vinyl alcohol)-β-tricalcium phosphate (PVA-PEEK/PVA-β-TCP) bilayered hydrogels by freezing-thawing with biomimetic properties for articular cartilage and subchondral bone is developed. The bilayered hydrogels microarchitecture consists of a highly porous and dense structure, and the internal structure were analyzed ...



Sclerostin Inhibition in the Management of Osteoporosis

Fri, 25 Mar 2016 23:00:00 +0100

Abstract The recognition of the importance of the Wnt-signaling pathway in bone metabolism and studies of patients with rare skeletal disorders characterized by high bone mass identified sclerostin as target for the development of new therapeutics for osteoporosis. Findings in animals and humans with sclerostin deficiency as well as results of preclinical and early clinical studies with sclerostin inhibitors demonstrated a new treatment paradigm with a bone building agent for the management of patients with osteoporosis, the antifracture efficacy, and long-term tolerability of which remain to be established in on-going phase III clinical studies. In this article we review the currently available preclinical and clinical evidence supporting the use of sclerostin inhibitors in osteo...



Glutamate Receptor Agonists and Glutamate Transporter Antagonists Regulate Differentiation of Osteoblast Lineage Cells

Fri, 25 Mar 2016 23:00:00 +0100

In this report, the expression of molecular transporters in osteoblast lineage cells was investigated to assess their roles in cell development and activity. Low-density arrays, covering membrane and vesicular transport molecules, were used to assess gene expression in osteoblasts representing early and late differentiation states. Receptors and transporters for the amino acid glutamate were found to be differentially expressed during osteoblast development. Glutamate is a neurotransmitter in the central nervous system, and the mechanisms of its release, signal transduction, and cellular reabsorption in the synaptic cleft are well understood. Less clear, however, is the control of equivalent processes in peripheral tissues. In primary osteoblasts, inhibition of glutamate transporters with ...



Osteoprotegerin in Chronic Kidney Disease: Associations with Vascular Damage and Cardiovascular Events

Fri, 25 Mar 2016 23:00:00 +0100

Abstract Vascular injury and dysfunction contribute to cardiovascular disease, the leading cause of death in patients with chronic kidney disease (CKD). Osteoprotegerin (OPG) is a soluble member of the tumor necrosis factor receptor superfamily that has been linked to atherogenesis and endothelial dysfunction. Elevated circulating OPG levels predict future cardiovascular events (CVE). Our aim was to evaluate the determinants of circulating OPG levels, to investigate the relationship between OPG and markers of vascular damage and to test whether OPG improves risk stratification for future CVE beyond traditional and renal-specific risk factors in a CKD population. 291 patients with CKD stage 1–5 not on dialysis were included in the study. In the multivariate analysis, OPG was a s...



To the Harvard 19: Do Better

Fri, 25 Mar 2016 19:56:52 +0100

To: Elizabeth Bartholet, Scott Brewer, Charles Donahue, Jr., Nancy Gertner, Janet Halley, Bruce L. Hay, Philip B. Heymann, David W. Kennedy, Duncan M. Kennedy, Randall L. Kennedy, Charles J. Ogletree, Jr., Richard D. Parker, J. Mark Ramseyer, David Rosenberg, Lewis D. Sargentich, David L. Shapiro, Henry J. Steiner, Jeannie C. Suk, Laurence H. Tribe There was no mutuality that night. The sense of entitlement to grope, mount, fondle, even penetrate  --  to any extent  --  any female body within reach that has a pulse, is not something that anyone should accept as reasonable, non-abusive, excusable behavior, even for a drunk guy. When this sense of entitlement is demonstrated, admittedly acted upon, and defended as such, it is clear that the person responsible, as well as the communit...



Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw.

Fri, 25 Mar 2016 18:58:02 +0100

CONCLUSIONS: This study reconfirms the results of our previous survey. Discontinuation of antiresorptive treatment may increase both fractures and ONJ. Immediate development of a strategy for sharing information about ONJ among physicians, dentists, and patients is required to reduce the incidence of both ONJ and skeletal events in osteoporosis treatment. Study limitations were selection bias due to low response rate and possible inaccurate responses to the questionnaire. PMID: 27007294 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)



Johns Hopkins Summer Research Opportunity 2016 (1st and 2nd Year Medical Students)

Fri, 25 Mar 2016 18:49:03 +0100

We are pleased to announce the Charles E. Silberstein Research Fellowship in the Johns Hopkins Department of Orthopaedic Surgery beginning in the summer of 2016 for 1st and 2nd year medical students.  (Source: Orthogate - Latest News)

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Quantification of fat deposition in bone marrow in the lumbar vertebra by proton MRS and in-phase and out-of-phase MRI for the diagnosis of osteoporosis.

Fri, 25 Mar 2016 17:39:04 +0100

Authors: Zhang L, Li S, Hao S, Yuan Z Abstract The goal for this study was to investigate if proton MRS (1H-MRS) and out-of-phase and in-phase MRI can quantify the fat deposition in bone marrow within the lumbar vertebra that can be used to distinguish well between osteoporosis patients and healthy control subjects. 68 subjects participated in this study. The diagnostic results from dual-energy x-ray absorptiometry served as the gold standard, which was able to separate the subjects into osteoporosis (38 subjects) and non-osteoporosis group (30 subjects). Then the 68 subjects were further scanned by 1H-MRS and in-phase and out-of-phase MRI and the findings from the imaging methods were also compared and analyzed. It was found that the measured signal intensity ratio(SIR), lipid-wat...



Patent troll files swath of suits against ortho companies

Fri, 25 Mar 2016 16:29:09 +0100

WiLan company Orthopedic Innovations is looking to bring in damages for infringed intellectual properties, filing 5 separate patent suits against major orthopedic companies last October. The suits are in relation to a patent it holds over “technologies related to a gap checking method and apparatus for shaping a femur preparatory to implanting a knee prosthesis,” which it claims each company infringed upon with a variety of different products. Included in the suit are ConforMIS (NSDQ:CFMS), DePuy Synthes, Stryker (NYSE:SYK), Zimmer Biomet (NYSE:ZBH) and Medacta. Each lawsuit was filed over Orthopedic Innovations Patent No. 6,575,980. In a filing against DePuy Synthes, the company claims that DePuy “designs, manufactures, and sells surgical techniques and products that i...



Losses widen for DJO Global as it exits the Empi distributorship business

Fri, 25 Mar 2016 14:29:06 +0100

Fourth-quarter and full-year losses widened for DJO Global, as it completed the exit of its Empi orthopedic stimulation business. Losses were -$49.6 million for the 3 months ended Dec. 31, 2015, as sales grew 6.1% to $308.0 million compared with Q4 2014. Full-year losses rose 276.6% to -$340.9 million, on sales growth of 2.4% to $1.11 billion compared with 2014. Adjusted to exclude 1-time and discontinued items from the Empi exit, earnings before interest, taxes, depreciation and amortization were $68.9 million for the 4th quarter and $249.0 million for the full year. “During the 4th quarter of 2015, we completed the wind-down of the Empi business and restated the historical financials to reflect Empi as discontinued operations and are pleased to report a strong quarter and full yea...



Reducing Healthcare Waste: Don't Expect Patients To Take The Lead

Fri, 25 Mar 2016 13:53:00 +0100

Lena Wright’s best friend was hunched over like a character from a French novel, with spinal bones so thin they would fracture with a fit of sneezing. Determined to avoid that fate, Wright (a pseudonym) asked her primary care doctor to test her for osteoporosis with a DEXA scan, also known as Dual Energy X-ray Absorption. The scan would send two X-ray beams through her bones, one high energy and the other low. The difference in how much energy passes through her bones would somehow (the wonders of physics!) allow her doctors to calculate the thickness of her skeleton. (Source: Forbes.com Healthcare News)

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Antepartum surgical management of Pott’s paraplegia along with maintenance of pregnancy during second trimester

Fri, 25 Mar 2016 13:25:05 +0100

Conclusion Although this is only a single case but being the first to our knowledge, the good results highlight the point that both surgical management and maintenance of pregnancy during second trimester complicated by Pott’s paraplegia are possible, involving a multi-disciplinary team approach for optimal maternal and fetal outcome. (Source: European Spine Journal)



The association between a lifetime history of work-related low back injury and future low back pain: a population-based cohort study

Fri, 25 Mar 2016 13:25:05 +0100

Conclusion Our study suggests that a history of work-related low back injury or taking time off work or having to perform light duties at work due to a work-related low back injury may be a risk factor for the development of troublesome LBP. Residual confounding may account for some of the observed associations, but this was less in the group who took time off work or had to work light duties due to a work-related low back injury. (Source: European Spine Journal)



Decompression of the gluteus medius muscle as a new treatment for buttock pain: technical note

Fri, 25 Mar 2016 13:25:05 +0100

Conclusion In patients with buttock pain, pain around the GMeM should be considered as a causative factor. Less invasive surgery with cutting and opening of the tight gluteal aponeurosis over the GMeM under local anesthesia yielded excellent clinical outcomes. (Source: European Spine Journal)

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FDA Drug Safety Communication: Safety update for osteoporosis drugs, bisphosphonates, and atypical fractures

Fri, 25 Mar 2016 12:51:00 +0100

[10-13-2010] The U.S. Food and Drug Administration (FDA) is updating the public regarding information previously communicated describing the risk of atypical fractures of the thigh, known as subtrochanteric and diaphyseal femur fractures, in patients who take bisphosphonates for osteoporosis. (Source: FDA Center for Drug Evaluation and Research - What's New)



Goldman Sachs gets in on Chinese cardiac valve maker Venus Medtech

Fri, 25 Mar 2016 12:22:15 +0100

Chinese replacement heart valve maker Venus Medtech said today that it won a $37 million commitment from Goldman Sachs (NYSE:GS). Hangzhou-based Venus said it’s also won backing from Qiming Venture Partners, Sequoia Capital China, and Dinova Venture Capital. The company already has a transcatheter aortic valve replacement on the market in the People’s Republic and said a pulmonary valve is in clinical trials. Venus said its Venus A-Valve is the only TAVR device that meets China Food & Drug Administration requirements. More than 40 patients have been implanted with the Venus P-Valve pulmonary replacement in a global trial, the company said, and a study aimed at winning CE Mark approval in the European Union is slated to start enrolling patient during the 1st half of the...



Exploring better options for ACL repairs

Fri, 25 Mar 2016 11:00:33 +0100

by Lisa Fratt An anterior cruciate ligament (ACL) tear can be a devastating sports injury. Every year, 400,000 people, many of them teen and young adult athletes, sustain ACL injuries or tears. Martha Murray, MD, an orthopedic surgeon at Boston Children’s Hospital, worked with a team of colleagues to create a new procedure known as bridge-enhanced ACL repair (BEAR) that encourages natural healing. Watch this animation to see how it works: Why do surgeons need a better way to repair ACL injuries? The current standard of care, surgical ACL reconstruction, is a good solution. But it is linked with a 20 percent risk of re-tearing the ACL, and many young patients face an increased risk of arthritis. Instead of removing the torn ACL and replacing it with a tendon graft, the BEAR technique us...



Arthroscopic Treatment of Traumatic Hip Dislocation.

Fri, 25 Mar 2016 10:11:02 +0100

Authors: Begly JP, Robins B, Youm T Abstract Traumatic hip dislocations are high-energy injuries that often result in considerable morbidity. Although appropriate management improves outcomes, associated hip pathology may complicate the recovery and lead to future disability and pain. Historically, open reduction has been the standard of care for treating hip dislocations that require surgical intervention. The use of hip arthroscopy to treat the sequelae and symptoms resulting from traumatic hip dislocations recently has increased, however. When used appropriately, hip arthroscopy is a safe, effective, and minimally invasive treatment option for intra-articular pathology secondary to traumatic hip dislocation. PMID: 27007728 [PubMed - as supplied by publisher] (Source: The Jou...

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Adenovirus-mediated expression of vascularendothelial growth factor-a potentiates bone morphogenetic protein 9-induced osteogenic differentiation and bone formation.

Fri, 25 Mar 2016 08:09:01 +0100

Authors: Pi CJ, Liang KL, Ke ZY, Chen F, Cheng Y, Yin LJ, Deng ZL, He BC, Chen L Abstract Mesenchymal stem cells (MSCs) are suitable seed cells for bone tissue engineering because they can self-renew and undergo differentiation into osteogenic, adipogenic, chondrogenic, or myogenic lineages. Vascular endothelial growth factor-a (VEGF-a), an angiogenic factor, is also involved in osteogenesis and bone repair. However, the effects of VEGF-a on osteogenic MSCs differentiation remain unknown. It was previously reported that bone morphogenetic protein9 (BMP9) is one of the most important osteogenic BMPs. Here, we investigated the effects of VEGF-a on BMP9-induced osteogenesis with mouse embryo fibroblasts (MEFs). We found that endogenous VEGF-a expression was undetectable in MSCs. Adeno...



Knee awareness and functionality after simultaneous bilateral vs unilateral total knee arthroplasty.

Fri, 25 Mar 2016 06:50:02 +0100

CONCLUSION: SBTKA and UTKA patients exhibited similar joint functionality and knee awareness. Our results support the use of SBTKA in selected patients suffering from clinically symptomatic bilateral osteoarthritis. PMID: 27004168 [PubMed] (Source: World Journal of Orthopaedics)



Outcomes of tenodesis of the long head of the biceps tendon more than three months after rupture.

Fri, 25 Mar 2016 06:50:02 +0100

CONCLUSION: Tenodesis of LHBT more than 3 mo following rupture had outcomes similar to tenodesis done within 3 mo of rupture but recurrent rupture occurred in 20%. PMID: 27004167 [PubMed] (Source: World Journal of Orthopaedics)

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Injuries in jumpers - are there any patterns?

Fri, 25 Mar 2016 06:50:02 +0100

Authors: Rocos B, Chesser TJ Abstract Suicide as a cause of death, affects every health system, and is a particular problem in heavily urbanised states and low and middle income countries (which account for 75% of suicide deaths). The World Health Organisation records that 800000 commit suicide each year, representing 1.4% of annual global deaths, and that suicide was the second leading cause of death in 15-29 year-olds across the world in 2012. In the United Kingdom, jumping from height accounts for 3%-5% of the 140000 suicide attempts annually is similar incidence to the rest of Europe. The Medline and EMBASE were interrogated for studies examining suicide caused by jumping from height. Manual screening of titles and abstracts was used to identify relevant works before data was e...